Abstract The Ibis M2016 variety is a bread wheat variety with medium-strong gluten that was obtained in the Wheat Genetic Improvement Program of the Bajío Experimental Field by hybridization through a simple cross between the Colibri and Finsi genotypes; its selection history is TC070080-2R-0C-0R-1CSE-0R. In plots of producers from El Bajío, it surpassed Cortazar S94 in grain yield by 23.8% and the varieties Alondra F2014, Luminaria F2012, Bárcenas S2002, Maya S2007, and Urbina S2007 by 3.4, 45.7, 41, 21.4, and 18.7%, respectively. It is moderately resistant to yellow rust; when Cortazar S94 reached 40% damage from the disease, Ibis M2016 showed damage ranging from 10 to 15%. The variety was developed from 2007, when the cross was made; in 2021, it was released as a commercial variety. Ibis M2016 was made available to producers to meet the demand for varieties with medium-strong gluten, resistant to rust, and with yields higher than those of commercial varieties. Ibis M2016 is recommended for sowing in the El Bajío region, which had altitudes of 1 500 to 1 800 m and includes part of the states of Guanajuato, Michoacán, Jalisco and Querétaro.

Resumen La variedad Ibis M2016 es un de trigo harinero de gluten medio fuerte, que fue obtenida en el Programa de Mejoramiento Genético de Trigo del Campo Experimental Bajío por hibridación, mediante una cruza simple entre los genotipos Colibri y Finsi, su historia de selección es TC070080-2R-0C-0R-1CSE-0R. En parcelas de productores de El Bajío superó en rendimiento de grano a Cortazar S94, con 23.8% y a las variedades Alondra F2014, Luminaria F2012, Bárcenas S2002, Maya S2007 y Urbina S2007 con 3.4, 45.7, 41, 21.4 y 18.7%, respectivamente. Es moderadamente resistente a la roya amarilla, cuando Cortazar S94 alcanzó el 40% de daño por la enfermedad, Ibis M2016 presentó daños que van del 10 al 15%. La variedad se desarrolló del año 2007, cuando se realizó la cruza, en 2021 se liberó como variedad comercial. Ibis M2016 se puso a disposición de los productores para satisfacer la demanda de variedades de gluten medio fuerte, resistentes a royas y con rendimientos superiores al de las variedades comerciales. Ibis M2016 se recomienda para siembras en la región de El Bajío que presentó alturas de 1 500 a 1 800 msnm y comprende parte de los estados de Guanajuato, Michoacán, Jalisco y Querétaro.

Abstract Background: High-risk Human Papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer and its preneoplastic lesions. HPV16 and 18 are the most frequent HR-HPV genotypes detected in cervical cancer. HR-HPV genome integration into the host cell is an important event in the carcinogenic process. However, it remains uncertain which stage of cervical carcinogenesis HPV16 and 18 integration occurs in the Chilean population. Aim: The goal of this study was to evaluate HPV16 and HPV18 integration in preneoplastic lesions of the cervix. Methods: DNA was extracted from 108 cervical scrape samples with preneoplastic lesions. HPV was genotyped using PCR and non-radioactive hybridization. The integration status of HPV16 and HPV 18 was determined by evaluating the E2 gene presence through PCR. Results: HPV16 and HPV18 tested positive in 36.1% and 12.0% of samples, respectively. HPV16 was found integrated in 23.1% of HPV 16 cases, while HPV 18 in 100% of samples positive for this viral genotype. Conclusions: HR-HPV integration is an early event in cervical carcinogenesis, occurring in nearly half of preneoplastic lesions and being more frequent in HPV18 than in HPV16. The evaluation of HR-HPV integration can be utilized as a complementary tool for detecting HPV in the Chilean population.

Resumen Introducción: El virus del papiloma humano de alto riesgo (VPH-AR) es responsable del cáncer de cuello uterino y sus lesiones preneoplásicas. Los genotipos VPH16 y VPH18 son los más frecuentes en este cáncer. La integración del VPH-AR en el genoma de la célula hospedera es crucial en la carcinogénesis cervical, pero la etapa en que ocurre en la población chilena es incierta. Objetivo: Evaluar la integración de VPH16 y VPH18 en lesiones pre-neoplásicas de cuello uterino. Métodos: Se analizaron 108 muestras de raspados cervicales. El VPH se genotipificó mediante reacción de polimerasa en cadena (RPC) e hibridación no radiactiva. La integración de VPH16 y VPH18 se determinó por presencia del gen E2 mediante RPC. Resultados: VPH16 y VPH18 se detectaron en 36,1% y 12,0% de las muestras, respectivamente. El VPH16 se integró en 23,1% de los casos de VPH16, mientras que VPH18 se integró en 100% de las muestras positivas para este genotipo. Conclusiones: La integración VPH-AR es un evento temprano en la carcinogénesis cervical que ocurre en casi la mitad de las lesiones pre-neoplásicas y es más frecuente en VPH18 que en VPH16. La evaluación de la integración VPH-AR puede ser una herramienta útil para detectar el virus en la población chilena.

This paper aims at presenting and discussing data from research done through an experience in two campuses of a Federal Institute of Education, Science and Technology in Northeast, Brazil, based on theories concerning digital literacies, education, and technology. As to this paper, digital literacies are understood as social practices regarding the use of digital devices as well as the hybrid performances with technologies of varied supports, such as analog and electronic devices that have been emerging since the last century. Structured observations and narrative interviews were the instruments adopted for data collection, and the analytical method was based on Freeman (1998) along with Auerbach and Silverstein's (2003) coding mechanisms. As a result, the emerging topics highlighted social use of technologies, the relevance of problematizing and thinking about meanings of the term technology as well as the importance of implementing social practices focused on the hybridization of devices instead of on the dissociation of technologies.

Este artículo tiene como objetivo presentar y discutir, con base en las teorías de las alfabetizaciones digitales, educación y tecnología, los datos de una investigación desarrollada a partir de la experiencia en dos campus de un Instituto Federal de Educación, Ciencia y Tecnología de la Región Nordeste. En este trabajo, las alfabetizaciones digitales son entendidas como prácticas sociales que involucran el uso de dispositivos digitales, pero, al mismo tiempo, como la hibridación de desempeños con tecnologías de diferentes soportes, como dispositivos analógicos y electrónicos, que ha surgido desde el siglo pasado. Las observaciones estructuradas y las entrevistas narrativas fueron los instrumentos de generación de datos, y el método de análisis se basó en Freeman (1998) y en los mecanismos de codificación de Auerbach y Silverstein (2003). Los resultados arrojaron luz sobre temas sociales acerca de los usos de las tecnologías, la necesidad de pensar y problematizar el término "tecnología", así como la relevancia de implementar prácticas sociales que pretendan la hibridación de dispositivos más que la segregación de tecnologías.

Este artigo objetiva apresentar e discutir, com base nas teorias dos letramentos digitais, educação e tecnologia, os dados de uma pesquisa desenvolvida a partir da vivência em dois campi de um Instituto Federal de Educação, Ciência e Tecnologia da Região Nordeste. Neste trabalho, letramentos digitais são entendidos como práticas sociais envolvendo usos de dispositivos digitais, mas, ao mesmo tempo, como a hibridização de performances com tecnologias de suportes diversos, a exemplo dos dispositivos analógicos e eletrônicos, que têm emergido desde o século passado. As observações estruturadas e as entrevistas narrativas foram os instrumentos de geração de dados, sendo o método de análise baseado em Freeman (1998) e nos mecanismos de codificação de Auerbach e Silverstein (2003). Os resultados lançaram luz a temas sociais sobre os usos de tecnologias, a necessidade de pensar e problematizar o termo “tecnologia”, assim como a relevância de implementar práticas sociais que tencionem a hibridização de dispositivos em vez da segregação de tecnologias.

Resumo Os cupins são conhecidos como insetos sociais em todo o mundo. Atualmente na China foram relatadas 473 espécies, 44 gêneros e 4 famílias de cupins. Destas, 111 espécies de Reticulitermes estão amplamente distribuídas em diferentes zonas da China. A temporada de voo de dispersão dessas espécies chinesas de Reticulitermes geralmente começa de fevereiro a junho, mas em algumas regiões diferentes espécies são distribuídas, compartilhando seus limites e tendo temporadas de voo sobrepostas. Essas razões tornam-se importantes fontes de hibridização entre duas populações heteroespecíficas de cupins. Foi confirmado que os ovos fertilizados e não fertilizados de alguns cupins Reticulitermes possuem capacidade de clivagem. Já os ovos não fertilizados de R. aculabialis, R. chinensis e R. labralis clivaram normalmente, e os únicos ovos não fertilizados de R. aculabialis se desenvolvem em embriões. R. flaviceps e R. chinensis foram observados com desenvolvimento embrionário anormal, e não eclosão de ovos por partenogênese. Eles foram relatados como mais ameaçadores para os recursos chineses à medida que se propagam com partenogênese, hibridização e reprodução sexual. Casca de ovo e macrófilos de ovos desempenham papéis importantes na identificação e controle de espécies, embora sejam pragas graves e causem uma ampla gama de danos a estruturas e produtos de madeira em residências, edifícios, materiais de construção, árvores, plantações e florestas na China continental.

Abstract Termites are known as social insects worldwide. Presently in China 473 species, 44 genera and 4 families of termites have been reported. Of them, 111 Reticulitermes species are widely spread in different zones of China. The dispersion flight season of these Chinese Reticulitermes species are usually started from February to June, but in some regions different species are distributed, sharing their boundaries and having overlapping flight seasons. These reasons become important sources of hybridization between two different heterospecific populations of termites. It was confirmed that the fertilized eggs and unfertilized eggs of some Reticulitermes termites have the capacity of cleavage. While the unfertilized eggs of R. aculabialis, R. chinensis and R. labralis cleaved normally and the only R. aculabialis unfertilized eggs develop in embryos. While, the R. flaviceps and R. chinensis were observed with their abnormal embryonic development, and not hatching of eggs parthenogenetically. They were reported more threatening to Chinese resources as they propagate with parthenogenesis, hybridization and sexual reproduction. Eggshell and macrophiles of eggs play important roles in species identification and control. Although, they are severe pests and cause a wide range of damages to wooden structures and products in homes, buildings, building materials, trees, crops, and forests in China’s Mainland.

ABSTRACT Objective: To report a rare case of a patient with a molecular diagnosis of Kleefstra syndrome (KS) who has four other chromosomal alterations involving pathogenic variants. Case description: Male patient, two years old, with global delay, including in neuropsychomotor development, ocular hypertelorism, broad forehead, brachycephaly, hypotonia, ligament laxity, unilateral single palmar crease and arachnoid cyst. The microarray-based comparative genomic hybridization (a-CGH) identified copy number variations (CNVs) in five regions: 9q34.3, 6p22.1, Yq11.223, Yp11.23, and 2q24.1. The heterozygous microdeletion in 9q34.3 involving the EHMT1 gene confirms the diagnosis of KS. Comments: The presence of pathogenic CNVs and/or those of uncertain significance, located on chromosomes 2, 6 and Y, may be contributing to a variability in the patient's clinical condition (arachnoid cyst, single palmar fold and ligament laxity), compared to other individuals with only KS genetic alteration, making the dignosis of the disease harder.

RESUMO Objetivo: Relatar um caso raro de paciente com diagnóstico molecular de síndrome de Kleefstra (SK) que apresenta quatro outras alterações cromossômicas envolvendo variantes patogênicas. Descrição do caso: Paciente masculino, dois anos de idade, com atraso global de desenvolvimento neuropsicomotor, hipertelorismo ocular, fronte ampla, braquicefalia, hipotonia, frouxidão ligamentar, prega palmar única unilateral e cisto aracnoide. Exame de hibridização genômica comparativa (a-CGH) identificou variações de número de cópias (CNV) em cinco regiões: 9q34.3, 6p22.1, Yq11.223, Yp11.23 e 2q24.1. A microdeleção heterozigótica em 9q34.3 confirma o diagnóstico de síndrome de Kleefstra. Comentários: A presença das CNV patogênicas e/ou de significado incerto, localizadas nos cromossomos 2, 6 e Y, pode estar contribuindo para uma variabilidade no quadro clínico do paciente (cisto aracnoide, prega palmar única e frouxidão ligamentar) em relação a outros indivíduos somente com alteração genética da SK, dificultando o diagnóstico da doença.

Abstract Public health systems have to evaluate how the use of traditional and complementary medicine can improve the population's health, mainly in developing countries. This research was carried out in the Salta city and the objectives were: 1) to know the plants used in urban herbal medicine; 2) inquire about the reasons for the consumption of medicinal plants, ailments, conditions and therapeutic practices; 3) know the cultural importance of plants through the Relative Importance Indices (RI), the Consensus Factor among informants (FCI) and the origin of the linked knowledge; 4) describe the plant acquisition spaces; 5) to know the perception of health personnel of formal medicine concerning the use of medicinal plants in the domestic environment and 6) to compare the diseases treated with herbal medicine and those with formal medicine. The quality-quantitative methodology of classical ethnobotany was implemented. Thirty-five participants residing in five neighborhoods were interviewed, and focus groups were held with health staff from three health centres located in the northern sector of the city linked to the neighborhoods mentioned above. The wealth of urban herbalism amounts to 120 medicinal taxa belonging to 110 genera and 52 botanical families; 63% are non-native plants and the most represented families were Asteraceae and Lamiaceae. The inhabitants of Salta have hybrid and dynamic botanical knowledge. The hybridization processes detected were fusion, recombination, new developments in innovative products and circulation of species. Three hundred thirteen medicinal uses were recorded for 63 types of conditions and ailments involving 13 body systems. The influential presence of complementary alternative medicines and the media in the dissemination of medicinal plants and derived products is noted. Among health staff, a great heterogeneity of feelings and knowledge was noted, highlighting the recognition of the use of plants by the related population; the lack of quantifiable scientific evidence on the benefits of its practice; the fear of adverse effects and the absence of formal knowledge about phytotherapy. Phytotherapy research must be deepened, and the processes of diversification and resignification of knowledge and practices about medicinal plants must be evaluated.

Resumen Los sistemas públicos de salud tienen que evaluar cómo el uso de la medicina tradicional y complementaria puede mejorar la salud de la población, principalmente en países en vía de desarrollo. Esta investigación se llevó a cabo en la ciudad de Salta y los objetivos fueron: 1) conocer las plantas utilizadas en medicina herbolaria urbana; 2) indagar acerca de las razones del consumo de las plantas medicinales, las dolencias, las afecciones y las prácticas terapéuticas; 3) conocer la importancia cultural de las plantas mediante los Índices de Importancia Relativa (IR), el Factor de Consenso entre los informantes (FCI) y el origen del conocimiento vinculado; 4) describir los espacios de adquisición de las plantas; 5) conocer la percepción del personal de la salud de la medicina formal en relación al uso de plantas medicinales en el ámbito doméstico y 6) comparar las enfermedades tratadas con la medicina herbolaria y aquellas con la medicina formal. Se implementó la metodología cuali-cuantitativa de la etnobotánica clásica. Se entrevistaron a 35 participantes residentes en cinco barrios y se realizaron grupos focales con el personal de salud de tres centros de salud ubicados en el sector norte de la ciudad vinculados a los barrios mencionados. La riqueza de la herbolaria urbana asciende a 120 taxones medicinales pertenecientes a 110 géneros y 52 familias botánicas; el 63% son plantas no nativas y las familias más representadas fueron Asteraceae y Lamiaceae. Los pobladores salteños poseen un conocimiento botánico híbrido y dinámico. Los procesos de hibridación detectados fueron fusión, recombinación, nuevos desarrollos en productos innovadores y circulación de especies. Se registraron 313 usos medicinales de 63 tipos de afecciones y dolencias que involucran a 13 sistemas corporales. Se advierte la presencia influyente de las medicinas alternativas complementarias y los medios de comunicación en la difusión de plantas medicinales y productos derivados. Entre el personal de salud se advirtió una gran heterogeneidad de sentires y saberes, destacándose el reconocimiento del uso de plantas por parte de la población vinculada; la falta de evidencia científica cuantificable sobre los beneficios de su práctica; el temor a los efectos adversos y la ausencia de conocimiento formal sobre la fitoterapia. Las investigaciones sobre fitoterapia se deben profundizar y estudiar los procesos de diversificación y resignificación de los saberes y prácticas sobre plantas medicinales.

Abstract The interest of this study has different directions. On the one hand, it is of interest to make known the story “En el lago Pátzcuaro” by Rubén M. Campos (1876-1945) in light of the material study of the Revista Moderna de México, specifically within its contexts of publication and edition; At the same time, it is of interest to show this narration as a result of the technological impact of the new means of representation and reproduction of images, such as photography and the cinematograph. Likewise, in the rise and desire for progress, the railroad, as a technological means, also played a very important role in shaping the ways of looking at and representing the national landscape and the modern “self”. So that the recovered text is shown as an example of aesthetic renewal and hybridization in literature from the reflection of the gaze conditioned and modified by various technological artifacts.

Resumen El interés de este estudio tiene diferentes direcciones. Por un lado, interesa dar a conocer el relato “En el lago Pátzcuaro” de Rubén M. Campos (1876-1945) a la luz del estudio material de la Revista Moderna de México, específicamente dentro de sus contextos de publicación y edición; a la vez, interesa mostrar esta narración como resultado del impacto tecnológico de los nuevos medios de representación y reproducción de imágenes, tales como la fotografía y el cinematógrafo. Asimismo, en el auge y anhelo de progreso, el ferrocarril, como medio tecnológico, jugó también un papel de gran importancia en la configuración de las formas de mirar y de representar el paisaje nacional y el “yo” moderno. De forma que el texto recuperado se muestra como un ejemplo de la renovación e hibridación estética en literatura a partir de la reflexión de la mirada condicionada y modificada por diversos artefactos tecnológicos.

This article explores the transformations of social demands in popular territories that inform the emerging challenges and the consequent forms of collective action of social movements in the Metropolitan Region of Belo Horizonte (RMBH). From the meetings of researchers and social activists in a training course, we analyze the articulation between the updated agendas and the ideas of Urban Reform and the Right to the City. The meetings promote discussions from the perspective of social movements on urban reform and the right to the city, in addition to disseminating practices that these actors build in their daily activities. The debates held during the course indicate a plurality of agendas and a hybridization of struggles for urban reform and the right to the city. Although historically guided by the housing issue, today there is a broad panorama of interests and needs that are articulated in the practices of social movements. Urban agroecology, for example, is linked to health, food security, the environment, and job and income generation. The scope of action of social movements has expanded towards the integration of agendas. This work contributes to advancing the analysis of the agents, interests and collective actions of social movements in the RMBH.

Este artigo explora as transformações das demandas sociais em territórios populares que informam os desafios emergentes e as consequentes formas de ação coletiva de movimentos sociais na Região Metropolitana de Belo Horizonte (RMBH). A partir dos encontros de pesquisadores e ativistas sociais em um curso de formação, analisamos a articulação entre as pautas atualizadas e o ideário da Reforma Urbana e do Direito à Cidade. Os encontros promovem discussões a partir da perspectiva dos movimentos sociais sobre a reforma urbana e o direito à cidade, além de difundir práticas que esses atores empregam em suas atividades cotidianas. Os debates realizados no curso indicam uma pluralidade de pautas e uma hibridização das lutas pela reforma urbana e pelo direito à cidade. Apesar de historicamente guiadas pela questão habitacional, hoje nota-se um amplo panorama de interesses e necessidades que são articuladas nas práticas dos movimentos sociais. À agroecologia urbana, por exemplo, vinculam-se saúde, segurança alimentar, meio ambiente e geração de emprego e renda. O escopo de ação dos movimentos sociais tem se ampliado na direção da integração das pautas. O presente trabalho contribui para avançar na análise sobre os agentes, interesses e ações coletivas de movimentos sociais da RMBH.  

Resumo O neonatologista é frequentemente o primeiro clínico a confrontar-se com condições genéticas não diagnosticadas no período pré-natal. Os avanços tecnológicos no campo da genética nas últimas décadas trouxeram possibilidades nunca antes imaginadas. Distantes estão os tempos em que pouco mais poderia ser oferecido aos doentes do que um cariótipo de sangue periférico. Metodologias mais recentes, como hibridização genómica comparativa ou sequenciação de Sanger e sequenciação de nova geração, permitem analisar mais detalhadamente o genoma humano, quer ao nível dos grandes rearranjos (deleções, duplicações), quer de variantes pontuais potencialmente patogénicas. Estas tecnologias de ponta têm sido úteis na descoberta de genes implicados em doenças há muito entendidas como de origem genética, mas cuja etiologia permanecia desconhecida. Apesar dos bons presságios, nenhum método é autossuficiente e todos apresentam as suas limitações. O objetivo desta revisão é atualizar os clínicos sobre os testes genéticos atualmente disponíveis e utilizados. Recordando que o primeiro genoma humano foi sequenciado há pouco mais de vinte anos, que novidades trarão os próximos vinte?

Abstract The neonatologist is often the first clinician to identify genetic disorders without prenatal diagnosis. Technological advances in genetics over the past few decades have opened up possibilities never before imagined. Gone are the days when we could offer our patients little more than a peripheral blood karyotype. Newer methods, such as comparative genomic hybridization or Sanger sequencing and next-generation sequencing, allow a more detailed analysis of the human genome, both at the level of large rearrangements (deletions, duplications) and potentially pathogenic point variants. High-tech technologies have been useful in uncovering genes involved in diseases that have long been known to have a genetic origin, but whose etiology has remained elusive. Despite the promise of these technologies, no method is self-sufficient, and all have limitations. The aim of this review is to update clinicians on the genetic tests that are currently available and in use. Given that the first human genome was sequenced just over twenty years ago, what news will the next twenty years bring?

Abstract The citrus trade market welcomes cultivars with different characteristics such as being totally seedless or having fewer seeds, having thin and vividness skin, high ratio of sugar to acid, being watery, easy peeling and relatively large fruit. Furthermore, a wide range of cultivars should be available according to fruit ripening time from very early (precocious) to very late (serotinous). ‘Yashar’ mandarin is a hybrid obtained by crossing of the ‘Minneola’ tangelo and ‘Changsha’ mandarin. The fruits of this cultivar grow in the northern regions of Iran, and it ripen in May, thus, they are considered the late-ripening mandarin cultivars. One of the deficiencies of this cultivar is that it is full of seeds (25-30). The aim was to evaluate pollination impacts regarding different sources of pollen grains (‘Valencia’ orange, ‘Hamlin’ orange, sour orange, and free pollination) on ‘Yashar’ mandarin characteristics. Two separate experiments were performed. In the first experiment, the effect of pollen grains of different citrus cultivars (‘Valencia’ orange, ‘Hamlin’ and sour orange) and a free-pollination treatment as a control group was evaluated. In the second experiment, the effect of foliar application of copper sulfate at the rate of 25 mg·L-1 was conducted in stages 30, 60 and 80 % of open flowers. One free pollination treatment as a control group was evaluated as well. The index of fruit technology was obtained by pollination with ‘Hamlin’ and sour orange pollen grains. The foliar spraying with copper sulfate, when 30 % of the flowers had opened, reduced the number of seeds in the ‘Yashar’ mandarin cultivar.

Resumen En el mercado comercial de los cítricos se aprecian los cultivares con diferentes características, como presentar menos semillas o carecer totalmente de éstas, una piel delgada y brillante, y una elevada proporción de dulzura frente a la acidez; además, de ser frutos jugosos, fáciles de pelar y relativamente grandes. También se debe disponer de una amplia gama de cultivares según el tiempo de maduración de la fruta, desde muy temprana (precoz) a muy retrasada (tardía). La mandarina ‘Yashar’ es un híbrido obtenido mediante la cruza del tangelo ‘Minneola’ y la mandarina ‘Changsha’. Los frutos de este cultivar crecen al norte de Irán, y maduran en mayo, por lo cual se considera como un cultivar de maduración tardía. Uno de los defectos de dicho cultivar es que tiene demasiadas semillas (entre 25 y 30). El objetivo fue evaluar los impactos de la polinización con diferentes fuentes de granos de polen (naranjas ‘Valencia’, ‘Hamlin’, agria y polinización libre) sobre las características de mandarina ‘Yashar’. Se desarrollaron dos experimentos. En el primero se evaluó el efecto de los granos de polen y un tratamiento de polinización libre (testigo). En el segundo se analizó el efecto de la aplicación foliar de 25 mg·L-1 de sulfato de cobre durante las etapas de 30, 60 y 80 % de flores abiertas y un tratamiento con polinización (testigo). El índice tecnológico más alto se obtuvo mediante la polinización con naranjas ‘Hamlin’ y agria. El asperjado foliar con sulfato de cobre, cuando el 30 % de las flores habían abierto, redujo el número de semillas en la mandarina Yashar.

Resumo Em O sol se põe em São Paulo, a escrita promove um exercício de alteridade, possibilita o contato com o outro e a consciência de si. O narrador, que recebeu a incumbência de narrar uma história que não lhe pertence, passa a refletir sobre seu próprio passado e identidade. Através do exercício narrativo, sua fratura linguística e cultural se expande, visto que, percebe em si a ausência de identificação com o repertório cultural que faz parte de suas origens. A partir desse espaço, de onde relata a origem do outro, sua consciência de não pertencimento é reforçada, o que intensifica sua angústia existencial. O esfacelamento do vínculo com as origens faz com que se eleja a instabilidade, a fragmentação, a hibridização e o jogo entre o ser e o parecer, como elementos constituintes de sua identidade. Logo, o narrador percebe que sua representação identitária, assim como a de tantos outros, se realiza através da narrativa do indivíduo em trânsito, do ser movente, da identidade em construção. Paulo alteridade pertence narrativo expande espaço reforçada existencial instabilidade fragmentação parecer Logo identitária outros trânsito movente construção

Abstract In o Sol se põe em São Paulo, Carvalho’s writing promotes an exercise of alterity, enabling contact with the other and self-awareness. The narrator, who has been given the task of narrating a story that does not belong to him, starts to reflect on his own past and identity. Through the narrative exercise, his linguistic and cultural fracture expands, since he perceives in himself the lack of identification with the cultural repertoire that is part of his origins. From this space, from where he reports the origin of the other, his awareness of not belonging is reinforced, which intensifies his existential anguish. The breakdown of the bond with his origins leads to instability, fragmentation, hybridization, a game between being and seeming to be chosen as constituent elements of his identity. Therefore, the narrator realizes that his identity representation, as well as that of so many others, takes place through the narrative of the individual in transit, of the moving being, of the identity under construction. Paulo Carvalhos Carvalho s alterity selfawareness. selfawareness self awareness. self-awareness him expands space reinforced anguish instability fragmentation hybridization Therefore representation others transit construction

Résumé Dans o Sol se põe em São Paulo, l'écriture promeut un exercice d'altérité, permettant le contact avec l'autre et la conscience de soi. Le narrateur, chargé de raconter une histoire qui ne lui appartient pas, commence à réfléchir sur son passé et son identité. À travers l'exercice narratif, sa fracture linguistique et culturelle s'élargit, puisqu'il perçoit en lui-même le manque d'identification au répertoire culturel qui fait partie de ses origines. De cet espace, d'où il raconte l'origine de l'autre, sa conscience de non-appartenance se renforce, ce qui intensifie son angoisse existentielle. La rupture du lien avec les origines fait de l'instabilité, de la fragmentation, de l'hybridation, du jeu de l'être et du paraître éléments constitutifs de son identité. Dès lors, le narrateur prend conscience que sa représentation identitaire, ainsi que celle de tant d'autres, se réalise à travers le récit de l'individu en transit, de l'être en mouvement, de l'identité en construction. Paulo lécriture l écriture daltérité, daltérité d altérité, altérité d'altérité lautre autre soi pas identité lexercice narratif sélargit, sélargit s élargit, élargit s'élargit puisquil puisqu luimême même didentification identification espace doù où lorigine origine lautre, autre, nonappartenance non appartenance renforce existentielle linstabilité, linstabilité instabilité, instabilité l'instabilité fragmentation lhybridation, lhybridation hybridation, hybridation l'hybridation lêtre être lors identitaire dautres, dautres autres, autres d'autres lindividu individu transit mouvement lidentité construction

ABSTRACT Introduction: Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations occurring after solid organ or bone marrow transplantation. The primary aims of our study were to characterize cumulative incidence of PTLDs, clinical and pathological features according to the Epstein-Barr virus (EBV) status and survival. Methods: This was a retrospective cohort study on adult and pediatric patients, from January 2001 to December 2017. The cumulative incidence of PTLD was calculated by analyzing all the patients transplanted at our hospital, based on the database of the Organ Donation and Ablation Authority of Argentina (INCUCAI). The Kaplan-Meier method was used to plot the survival. Results: Fifty-eight cases of biopsy-confirmed PTLD were identified and 12 cases of clinical data were incomplete and these patients were excluded. The median age at the time of the PTLD diagnosis was 17.5 years (interquartile range [IQR] 9 - 57). The median interval between transplant and PTLD diagnosis was 39 months (IQR 9 - 113). The most commonly transplanted organ was the liver (24 cases, 52.2%), followed by kidney (20 cases, 43.5%). The Epstein-Barr encoding region in situ hybridization (EBER ISH) was positive in 29 (69.8%) of the 43 evaluable biopsies. The PTLD cumulative incidence was 1.84% (95%CI 1.77 - 1.91) for solid organ and 0.84% (95%CI 0.48 - 1.2) for bone marrow transplant patients. The overall survival rate at 5 years was 0.77 (95%CI 0.61 - 0.87). Subgroups by the EBV EBER status, transplant type, PTLD subtype and age group (adult vs. pediatric) showed no statistically significant association with the overall survival. Conclusion: The PTLD incidence was similar to that of previous series and the EBER did not appear as a relevant factor in our patient survival.

Resumen El propósito de este artículo es hacer una reflexión teórica contingente acerca de si la “nueva derecha” que está emergiendo en la actualidad es radical o simplemente una continuación de la derecha chicago gremialista que ha sido hegemónica en estos últimos años en la historia política reciente en Chile. Para discutir los límites de las derechas, sus particularidades y aspectos analíticos, se utiliza una bibliografía especializada sobre las derechas en Chile y en el extranjero. En este artículo sugerimos que las derechas se caracterizaron por la hibridación ideológica, cuya característica axial es la co-presencia o integración dialéctica de una amplia gama de discursos de diferentes tradiciones ideológicas y de pensamiento. Al final de este escrito, se hipotetiza la posibilidad de emergencia de una derecha nacionalista mesocrática y popular comprometida con una integración nacional basada en ideales republicanos, y una derecha radical xenófoba, que fomente la adhesión a valores de exclusión ante la llegada de inmigrantes en los últimos años en Chile.

Resumo O objetivo deste artigo é fazer uma reflexão teórica contingente sobre se a “nova direita” que está surgindo é radical ou simplesmente uma continuação da direita chicago gremialista que tem sido hegemônica nos últimos anos na história política recente do Chile. Para discutir os limites das direitas, suas particularidades e aspectos analíticos, utiliza-se uma bibliografia especializada sobre direitos no Chile e no exterior. Neste artigo sugerimos que a direita se caracterizou pela hibridização ideológica, cuja característica axial é a co-presença ou integração dialética de uma ampla gama de discursos de diferentes tradições ideológicas e de pensamento. Ao final desta escrita, uma nova possibilidade de emergência de uma direita nacionalista mesocrática e popular, comprometida com uma integração nacional baseada em ideais republicanos, e uma direita radical xenófoba, que promove a adesão a valores de exclusão antes da chegada de imigrantes em últimos anos no Chile.

Abstract The purpose of this article is to make a contingent theoretical reflection on whether the "new right" that is emerging is radical or simply a continuation of the chicago gremialista right that has been hegemonic in recent years in the recent political history of Chile. To discuss the limits of rights, their particularities and analytical aspects, a specialized bibliography on rights in Chile and abroad is used. In this article we suggest that the right wing was characterized by ideological hibridation, whose axial characteristic is the co-presence or dialectical integration of a wide range of discourses from different ideological traditions and thought. At the end of this writing, a new possibility of the emergence of a mesocratic and popular nationalist right committed to a national integration based on republican ideals, and a xenophobic radical right, which promotes adherence to values of exclusion in the face of the arrival of immigrants in recent years in Chile.

Resumen El carcinoma tipo-linfoepitelioma pulmonar es una variante rara de carcinoma de células no pequeñas de pulmón, representa aproximadamente 0.7% de todos los casos. Está usualmente asociado con la infección por el virus de Epstein-Barr y es más prevalente en el Sureste de Asia; sin embargo, es extremadamente raro en Améri ca Latina. Informamos el caso de un hombre de 65 años de edad con un carcinoma tipo-linfoepitelioma pulmo nar, que se presentó con tos, disnea y pérdida de peso. La TAC de tórax mostró nódulo mal definido localizado en el pulmón derecho. Se realizó biopsia transtorácica de la lesión, y el estudio microscópico reveló células gran des poligonales dispuestas en mantos, infiltrados por abundantes linfocitos y células plasmáticas, alrededor del intersticio. Las células neoplásicas fueron positivas para citoqueratina 5/6 y p63, y negativas para Napsina A y el factor de transcripción tiroideo 1 (TTF-1). La expre sión de PD-L1 fue positivo (aproximadamente 100%) por inmunohistoquímica; así como el núcleo de las células neoplásicas mediante hibridación in situ para el RNA codificado por el virus de Epstein-Barr (EBER-ISH). El paciente recibió seis ciclos de un esquema combinado de quimioterapia basado en platino (gencitabina/cisplatino) más durvalumab. Presentó progresión de la enfermedad y finalmente murió 9 meses después del diagnóstico.

Abstract Pulmonary lymphoepithelioma-like carcinoma is a rare type of non-small cell lung cancer, it accounts for approximately 0.7% of all cases. It is usually associated with Epstein-Barr virus infection and is more prevalent in Southeast Asia; however, it is extremely rare in Latin America. We present a 65-year-old man with a primary pulmonary lymphoepithelioma-like carcinoma, who presented with cough, dyspnoea and weight loss. Com puter tomographic scan of the thorax showed a nodule localized in the right lung. A transthoracic biopsy of the lung lesion was made and the microscopic obser vation revealed large polygonal cells that proliferated in a nest pattern with infiltration by lymphocytes and plasma cells around the interstitium. The tumour cells were positive for citokeratin 5/6 and p63, and negative for Napsin A and thyroid transcription factor 1 (TTF-1). PD-L1 expression was positive (approximately 100%) in the immunohistochemical study, and the nuclei of the tumour cells were positive for EBV-encoded small RNA in-situ hybridization (EBER-ISH). The patient underwent six cycles of platinum-based combination (gencitabine/ carboplatin) chemotherapy plus durvalumab. He pre sented progression of the disease and finally he died 9 months after diagnosis.