Exploring the triacylglycerols composition in milk samples from different ruminant species is crucial for dairy product development. Identifying the fatty acid (FA) composition in human milk is essential and is usually performed using gas chromatography (GC). Heat maps are useful for visualizing these results, aiding in pattern identification and relationships between samples and variables. Additionally, nuclear magnetic resonance (NMR) spectroscopy provides important qualitative and quantitative information about fatty acids (FA). In the present study, we compare the fatty acid composition in samples of HM, cow milk, and goat milk, as well as to demonstrate their positional distribution in triacylglycerols (TAGs). Human milk contains 49.21% saturated fatty acids (SFAs), 34.32% monounsaturated fatty acids (MUFA), and 16.47% polyunsaturated fatty acids (PUFA), including 2.14% docosahexaenoic acid (DHA) and 13.02% linoleic acid (LA). On the other hand, cow and goat milk have higher proportions of SFAs (56.2 and 58.02%, respectively) and MUFAs (40.56 and 40.95%, respectively), but lower amounts of PUFAs (3.24 and 1.03%, respectively), with significantly lower quantities of DHA (0.03 and 0.43%, respectively) and LA (1.46 and 2.76%, respectively). Additionally, fatty acids in ruminant milk mainly consist of long-chain fatty acids (LCFAs), with oleic acid being the most abundant. development FA (FA GC. GC . (GC) results variables Additionally NMR (NMR FA. study HM TAGs. TAGs (TAGs) 4921 49 21 49.21 SFAs, , (SFAs) 3432 34 32 34.32 MUFA, MUFA (MUFA) 1647 16 47 16.47 PUFA, PUFA (PUFA) 214 2 14 2.14 (DHA 1302 13 02 13.02 LA. (LA) hand 56.2 562 56 (56. 5802 58 58.02% respectively 40.56 4056 40 (40.5 4095 95 40.95% respectively, 3.24 324 3 24 (3.2 103 1 03 1.03% 0.03 003 0 (0.0 043 43 0.43% 1.46 146 46 (1.4 276 76 2.76% respectively. longchain long chain LCFAs, LCFAs (LCFAs) abundant (GC (TAGs 492 4 49.2 (SFAs 343 34.3 (MUFA 164 16.4 (PUFA 2.1 130 13.0 (LA 56. 5 (56 580 58.02 40.5 405 (40. 409 9 40.95 3.2 (3. 10 1.03 0.0 00 (0. 04 0.43 1.4 (1. 27 7 2.76 (LCFAs 49. 34. 16. 2. 13. (5 58.0 40. (40 40.9 3. (3 1.0 0. (0 0.4 1. (1 2.7 ( 58. (4

The history of the discovery, use, and development of dyes is closely linked to the history of humanity itself. Among the first records of human civilization are cave paintings made from, e.g., fruits, plants, minerals, and insects. Over the centuries, using different techniques, colors have been given to all types of materials and products, from clothing to food. The chemicals responsible for colors are dyes - a vast collection of molecules of the most varied compositions, but which have in common the absorption of light within the visible window of the electromagnetic spectrum. This article aims not only to review the properties of some classes of natural dyes, their origins, and their applications but also to describe the various computational chemistry methods involved in designing new bio-inspired molecules. discovery use itself eg e g e.g. fruits plants minerals insects centuries techniques products food compositions spectrum origins bioinspired bio inspired e.g

Iron is an important ion that regulates many metabolic functions in the human body, and its deficiency or overload can cause serious health problems. In view of this, the development of tools that can quantify iron in aqueous media is quite valuable. A new material based on a metal-organic framework (MOF) and a calixarene derivative (CALIX), here named CALIX@UiO-66-NH2, was successfully prepared and used as a luminescent sensor for iron ions in a water matrix containing various metal ions. The post-synthetic modification was demonstrated to be efficient on the MOF (UiO-66-NH2) modification, leading to a hybrid platform. The effect of the combination of both components (MOF and CALIX) led to a platform more sensitive to iron detection than the independent compounds. The CALIX@UiO-66-NH2 sensor shows a linear response toward Fe3+ ions with satisfactory linearity (R2 = 0.994) within the concentration range of 6.74 × 10−6−1.72 × 10−5 mol L−1. The limit of detection was determined to be as low as 1.6 mg L−1. The data demonstrate that CALIX@UiO-66-NH2 is an excellent probe for detecting Fe3+, as confirmed by almost complete fluorescence suppression. body problems this valuable metalorganic organic CALIX, CALIX , (CALIX) CALIX@UiO66NH2, CALIXUiO66NH2 CALIXUiONH CALIX@UiO 66 NH2, UiO NH2 NH postsynthetic post synthetic UiO66NH2 UiONH (UiO-66-NH2 compounds CALIX@UiO66NH2 CALIX@UiO-66-NH Fe3 Fe R2 R (R 0.994 0994 0 994 674 6 74 6.7 106172 10 1 72 10−6−1.7 105 5 10− L1 L L−1 16 1. suppression (CALIX CALIXUiO CALIXUiO66NH UiO66NH (UiO-66-NH CALIX@UiO66NH 0.99 099 99 67 7 6. 10617 10−6−1. L− 0.9 09 9 1061 10−6−1 0. 106 10−6− 10−6

RESUMO: Os padrões paisagísticos em zonas montanhosas com rápido desenvolvimento económico são fortemente afetados por múltiplas atividades humanas. No entanto, as mudanças nas alterações da paisagem nas áreas montanhosas cársticas atribuídas a atividades humanas complexas permanecem obscuras. A investigação sobre o grau de alteração da paisagem em zonas montanhosas sob a influência das atividades humanas é de grande importância para a conservação e gestão científica das paisagens montanhosas. Selecionamos zonas rurais com quatro tipos típicos de acidentes geográficos de pequena escala em áreas montanhosas como objetos de pesquisa e analisamos a resposta das mudanças na perturbação da paisagem rural à atividade humana nessas áreas. Nossos resultados revelam que o grau de alteração da paisagem e a atividade humana influenciam o aumento do índice na maioria das áreas montanhosas. As mudanças na atividade humana e nas perturbações paisagísticas são geralmente observadas na região de baixo relevo do terreno. A utilização intensiva do solo associada ao rápido desenvolvimento econômico tem um sério impacto negativo no grau de perturbação da paisagem, enquanto os projetos de restauração ecológica exercem um impacto positivo. Acelerar a implementação dos projetos para área “verde” e regular a expansão não regulamentada da produção e da terra viva são medidas cruciais para a gestão ecológica em áreas montanhosas cársticas. As futuras estratégias de gestão ecológica deverão centrar-se em áreas de terreno relativamente planas. Nossas descobertas contribuem para a gestão da paisagem e a regulação da atividade humana de diferentes tipos de relevo de pequena escala em áreas montanhosas cársticas. RESUMO entanto obscuras positivo verde “verde centrarse centrar se planas

ABSTRACT: Landscape patterns in mountainous areas with rapid economic development are strongly affected by multiple human activities. However, the changes in landscape disturbances across karst mountainous areas attributed to complex human activities remain unclear. Research on the degree of landscape disturbance in mountainous areas under the influence of human activities is of great significance to the conservation and scientific management of mountainous landscapes. We selected rural zones with four typical small-scale landform types in karst mountainous areas as the research objects and analyzed the response of changes in rural landscape disturbance to human activity in these areas. Our results revealed that the landscape disturbance degree and human activity influence index increase in the majority of karst mountainous areas. The changes in human activity and landscape disturbances are generally observed in the low terrain relief region. High-intensity land use associated with rapid economic development has a serious negative impact on the degree of landscape disturbance, while ecological restoration projects exert a positive impact. Accelerating the implementation of the grain for green project and regulating the unregulated expansion of production and living land are crucial measures for the ecological management in karst mountainous areas. Future ecological management strategies should focus on relatively flat terrain areas. Our findings contributed to the landscape management and human activity regulation of different small-scale landform types in karst mountainous areas. ABSTRACT However unclear landscapes smallscale small scale region Highintensity High intensity

ABSTRACT Introduction/framework/objectives: Artificial Intelligence has shown very intense development in recent years, in several areas, with Work Market being no exception. Furthermore, many researchers predict drastic changes in the way it is organized and consequent unemployment and associated economic, social, legal and emotional issues. The aim of this review is to summarize the data that will help to clarify the situation and better guide Occupational Health and Safety professionals. Methodology: This is a Bibliographic Review, initiated through a search carried out in April 2023 in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content: Artificial networks function as models with the capacity to store and use data, through simplified application algorithms. They mimic human neural networks; making the best decision, based on the information collected, making it possible to carry out tasks previously considered exclusively human. The machine progressively learns from its mistakes; that is, being able to solve problems for which they were not programmed, based on "experience", examples and analogies. Discussion and Conclusions: The consequences described in the literature regarding the interaction of Artificial Intelligence with Work are not consensual, even though most researchers consider that this will be the most abrupt and serious change faced by humanity, to the extent that it could be possible that the majority of the world's population become unemployed and without a means of subsistence, with all the associated implications, in a much shorter period of time than most can imagine. Some countries value this issue more, which is why they have already started studies or even applied practical measures to try to alleviate these problems. It would be very relevant to publicize the topic to employers, managers, human resources and workers, also evaluating how many companies apply Artificial Inteligence, in what way and how this has changed variables such as productivity, number of jobs and type of tasks; as well as what were the main mistakes made on this journey and what are the best ways to mitigate them, publicizing the process and the conclusions obtained, publishing such information in a magazine in the area.

RESUMO Introdução/enquadramento/objetivos: A Inteligência Artificial tem apresentado um desenvolvimento muito intenso nos últimos anos, em diversas áreas, não sendo o Mercado de Trabalho uma exceção. Para além disso, muitos investigadores preveem mudanças drásticas na forma de este ser organizado e consequente alteração a nível de desemprego e questões económicas, sociais, legais e emocionais associadas. Pretende-se com esta revisão sintetizar os dados que mais ajudarão a elucidar a situação e a melhor orientar os profissionais da Saúde e Segurança Ocupacionais. Metodologia: Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023 nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo: As redes artificiais funcionam como modelos com capacidade para armazenar e usar dados, através de algoritmos de aplicação simplificada. Eles imitam as redes neuronais humanas; tomando a melhor decisão, em função da informação recolhida, possibilitando a realização de tarefas anteriormente consideradas como exclusivamente humanas. A máquina aprende progressivamente com os seus erros; ou seja, passa a conseguir resolver problemas para os quais não foram programadas, em função da "experiência", exemplos e analogias. Discussão e Conclusões: As consequências descritas na literatura em relação à interação da Inteligência Artificial com o Trabalho não são consensuais, ainda que a maioria dos investigadores considere que isso será a mudança mais brusca e grave enfrentada pela humanidade, na medida em que poderá ser possível que a maioria da população mundial fique desempregada e sem meios de subsistência, com todas as implicações associadas, num prazo muito mais curto do que a maioria poderá imaginar. Alguns países valorizam mais este assunto, pelo que já iniciaram estudos ou até a aplicação de medidas práticas para tentar atenuar esses problemas. Seria muito relevante divulgar o tema perante empregadores, chefias, recursos humanos e trabalhadores, avaliando também quantas empresas aplicam a Inteligência Artificial, de que forma e como tal alterou variáveis como produtividade, número de postos de trabalho e tipo tarefas; bem como quais os principais erros executados nessa caminhada e quais as melhores formas de os atenuar, divulgando o processo e as conclusões obtidas, publicando tais informações em revista da área.

Resumen: Este artículo analiza la centralidad de las políticas públicas de seguridad y justicia en América Latina y el Caribe a partir de diversas técnicas de investigación teórico (análisis documental y bibliográfico) y trabajo de campo (visitas “in loco” y observaciones participantes), realizadas entre 2015 y 2021. Se parte del supuesto de que la violencia y las inseguridades son abordadas como un obstáculo flagrante para el desarrollo humano y la consolidación del estado de derecho en la región. Se identifica, basado en la literatura especializada y estudio comparado de estas políticas públicas, la relevancia del papel que juega el liderazgo político del estado y el compromiso cívico de varios actores sociales en torno a una gobernanza territorial integrada e integral de políticas de seguridad pública Ciudadana dedicados a salvar y preservar vidas. Resumen análisis bibliográfico visitas in loco participantes, participantes , participantes) 201 2021 región identifica vidas 20 202 2

Abstract: This article analyzes the centrality of public security and justice policies in Latin America and the Caribbean based on various theoretical research techniques (documental and bibliographical analysis) and fieldwork (“in loco” visits and participant observations), undertaken between 2015 and 2021. It starts from the assumption that violence and insecurities are approached as a flagrant obstacle to human development and the consolidation of the rule of law in the region. It is identified, in the comparison of the specialized literature and in the comparative study of these public policies, the relevance of the role played by the political leadership of the State and the civic engagement of several social actors around an integrated and integral territorial governance of citizen public security policies. Despite a punitive political culture and a history of authoritarian governments in the region, there are, after all, key principles and concepts for a new type of governance of citizen security (and justice) in Brazil and in the region aimed at saving and preserve lives. Abstract documental analysis loco observations, observations , observations) 201 2021 identified all lives 20 202 2

Resumo: Este artigo analisa a centralidade das políticas públicas de segurança e justiça na América Latina e no Caribe com base em diversas técnicas de pesquisa teórica (análise documental e bibliográfica) e de campo (visitas “in loco” e observações participantes), empreendidas entre 2015 e 2021. Parte-se do pressuposto de que as violências e inseguranças são abordadas como um flagrante obstáculo ao desenvolvimento humano e à consolidação do estado de direito na região. Identifica-se, no cotejo da literatura especializada e no estudo comparado dessas políticas públicas, a relevância do papel desempenhado pela liderança política do estado e pelo engajamento cívico de diversos atores sociais em torno de uma governança territorial integrada e integral das políticas de segurança pública cidadã. Inobstante a uma cultura política punitiva e a um histórico de governos autoritários na região, vislumbram-se, afinal, princípios e conceitos-chave para uma governança de novo tipo da segurança cidadã (e justiça) no Brasil e na região voltada a salvar e a preservar vidas. Resumo análise bibliográfica visitas in loco participantes, participantes , participantes) 201 2021 Partese Parte se Identificase, Identificase Identifica se, Identifica-se vislumbramse, vislumbramse vislumbram vislumbram-se afinal conceitoschave conceitos chave vidas 20 202 2

Abstract Purpose: To document and analyze the experience of creation, growth and decline of a Solidarity Collaboration Network in Mexico City based on the theoretical-methodological approach of the Actor-Network Theory, in order to understand the role of the key actors, the dynamics that are experienced and the challenges and problems they face in their different stages of development. Methodological design: From a qualitative approach and through a case study, we propose the use of the translation process of the Actor-Network Theory as a theoretical-methodological guide to explore and interpret the findings. Results: The paper reveals the different maneuvers, actions and tensions that led to the construction of the emerging network and its subsequent decline. Five moments describing this process were analyzed: planning of the venture, creation, formalization, growth and decline of the network where both human and non-human actors have influence in different parts of the process. Research limitations: Are linked to the fact that the findings arise from a specific case, however, they can serve as a guide for the study of similar cases and, above all, to generate a greater understanding of the different actions that can arise in the operation of a collaborative network. Findings: The paper reveals the key role of both human and non-human actors and how they influenced both the growth and decline of the network. It also identifies new facets of the emergence and development of a Solidarity Collaborative Network as a function of the incorporation of the translation process. Methodologically, it was possible to observe the value of the Actor-Network Theory as a relevant methodological theoretical tool that can help to analyze and describe how a collaborative network is constituted and stabilized.

Resumen Objetivo: Documentar y analizar la experiencia de creación, crecimiento y declive de una Red de Colaboración Solidaria en la Ciudad de México a partir del enfoque teórico-metodológico de la Teoría del Actor-Red, con la finalidad de conocer el papel de los actores clave, las dinámicas que se viven y los retos y problemáticas a las que se enfrentan en sus diferentes etapas de desarrollo. Diseño metodológico: Desde un enfoque cualitativo y a través del estudio de caso se propone la utilización del proceso de traducción de la Teoría del Actor-Red como guía teórica-metodológica, para explorar e interpretar los hallazgos. Resultados: El trabajo revela las diferentes maniobras, acciones y tensiones que dieron lugar a la construcción de la red emergente y su posterior declive. Se analizaron cinco momentos que describen este proceso: planeación del emprendimiento, creación, formalización, crecimiento y declive de la red donde tienen influencia tanto los actores humanos como no humanos en diferentes partes del proceso. Limitaciones de la investigación: Están vinculadas al hecho de que los hallazgos surgen de un caso específico, sin embargo, estos pueden servir de guía para el estudio de casos similares y, sobre todo, para generar una mayor comprensión de las diferentes acciones que pueden surgir en el funcionamiento de una red colaborativa. Hallazgos: El trabajo revela el papel clave de los actores tanto humanos como no humanos y cómo influyeron tanto en el crecimiento como en el declive de la red. Asimismo, se identifican nuevas facetas que experimentan el surgimiento y desarrollo de una Red de Colaboración Solidaria (RCS) en función de la incorporación del proceso de traducción. Metodológicamente, se pudo observar el valor de la Teoría del Actor-Red como una herramienta teórica metodológica pertinente que puede ayudar a analizar y describir cómo se constituye y estabiliza una red de colaboración.

Abstract Purpose: To identify the challenges faced by nanomedicine in Mexico, according to the opinion of experts in the field. Methodological design: Semi-structured interviews were conducted with Mexican researchers in the field of nanomedicine. The participants were selected through purposive sampling. Interviews were both online and face-to-face. The information was processed with ATLAS.ti software. Results: Challenges were identified in different areas: financing, social benefit, human resources, infrastructure, nanotoxicology, patenting, preclinical and clinical research, academia-industry linkage, regulation, scientific policy and multidisciplinary work. Research limitations: Interviews included researchers only. It would be necessary to interview other agents involved in the nanomedicine chain of value, such as entrepreneurs and health sector managers. Findings: The main challenges facing nanomedical research in Mexico are the following: reduced funding, research with little impact on society, lack of specific educational programs in nanomedicine, low patenting activity, weak links between academia and industry, and lack of regulation. Some proposals to address these challenges are analyzed in this paper.

Resumen Objetivo: Identificar los desafíos que enfrenta la investigación en nanomedicina en México según la opinión de expertos en la materia. Diseño metodológico: Se realizaron entrevistas semiestructuradas a investigadores mexicanos del área de nanomedicina. Los entrevistados fueron seleccionados a través de un muestreo intencional. Las entrevistas se llevaron a cabo de manera presencial y a distancia. El procesamiento de la información se realizó con el software ATLAS.ti. Resultados: Se identificaron desafíos en distintos rubros: financiamiento, beneficio social, recursos humanos, infraestructura, nanotoxicología, patentamiento, investigación preclínica y clínica, vinculación academia-industria, regulación, política científica y trabajo multidisciplinario. Limitaciones de la investigación: Las entrevistas se realizaron únicamente a investigadores. Sería necesario entrevistar a otros agentes involucrados en la cadena de valor de la nanomedicina tales como empresarios y funcionarios del sector salud. Hallazgos: Los principales desafíos que enfrenta la investigación nanomédica en México son el financiamiento reducido, investigaciones con poca incidencia en la sociedad, inexistencia de programas educativos específicos en nanomedicina, escaso patentamiento, nula vinculación con empresas y falta de regulación. Algunas propuestas para encarar estos desafíos se analizan en el presente trabajo.

ABSTRACT Introduction: Although nerves and vessels of the penis play important role in erection, there are few studies on their development in human fetus. Therefore, the objective of the present study is to analyze, quantitatively, in the corpora cavernosa and corpus spongiosum, the development of the nerves and vessels in the fetal penis at different gestational ages. Material and Methods: Fifty-six fresh, macroscopically normal human fetuses aged from 13 to 36 weeks post-conception (WPC) were used. Gestational age was determined by the foot length criterion. Penises were immediately fixed in 10% formalin, and routinely processed for paraffin embedding, after which tissue sections from the mid-shaft were obtained. We used immunohistochemical staining to analyze the nerves and vessels in the corpus cavernous and in the corpus spongiosum. These elements were identified and quantified as percentage by using the Image-J software. Results: The quantitative analysis showed that the percentage of nerves varied from 3.03% to 20.35% in the corpora cavernosa and from 1.89% to 23.88% in the corpus spongiosum. The linear regression analysis indicated that nerves growth (incidence) in the corpora cavernosa and corpus spongiosum correlated significantly and positively with fetal age (r2=0.9421, p<0.0001) and (r2=0.9312, p<0.0001), respectively, during the whole fetal period studied. Also, the quantitative analysis showed that the percentage of vessels varies from 2.96% to 12.86% in the corpora cavernosa and from 3.62% to 14.85% in the corpus spongiosum. The linear regression analysis indicated that vessels growth (appearance) in the corpora cavernosa and corpus spongiosum correlated significantly and positively with fetal age (r2=0.8722, p<0.0001) and (r2=0.8218, p<0.0001), respectively, during the whole fetal period studied. In addition, the linear regression analysis demonstrated a more intense growth rate of nerves in the corpus spongiosum during the 2nd trimester of gestation, when compared with nerves in the corpora cavernosa. In addition, the linear regression analysis demonstrated a more intense growth rate of vessels in the corpus spongiosum when compared with the corpora cavernosa, during the whole fetal period studied. Conclusions: In the fetal period, the human penis undergoes major developmental changes, notably in the content and distribution of nerves and vessels. We found strong correlation between nerves and vessels growth (amount) with fetal age, both in the corpora cavernosa and corpus spongiosum. There is significant greater proportional number of nerves than vessels during the whole fetal period studied. Also, nerves and vessels grow in a more intense rate than that of the corpora cavernosa and corpus spongiosum areas. Introduction erection fetus Therefore quantitatively ages Methods Fiftysix Fifty six fresh 1 3 postconception post conception WPC (WPC criterion 10 formalin embedding midshaft mid shaft obtained ImageJ Image J software Results 303 03 3.03 2035 20 35 20.35 189 89 1.89 2388 23 88 23.88 incidence (incidence r2=0.9421, r209421 r r2 0 9421 (r2=0.9421 p<0.0001 p00001 p 0001 r2=0.9312, r209312 9312 (r2=0.9312 p<0.0001, , respectively studied Also 296 2 96 2.96 1286 12 86 12.86 362 62 3.62 1485 14 85 14.85 appearance (appearance r2=0.8722, r208722 8722 (r2=0.8722 r2=0.8218, r208218 8218 (r2=0.8218 addition nd gestation Conclusions changes amount (amount areas 30 3.0 203 20.3 18 8 1.8 238 23.8 r2=0.9421 r20942 942 (r2=0.942 p<0.000 p0000 000 r2=0.9312 r20931 931 (r2=0.931 29 9 2.9 128 12.8 6 3.6 148 14.8 r2=0.8722 r20872 872 (r2=0.872 r2=0.8218 r20821 821 (r2=0.821 3. 20. 1. 23. r2=0.942 r2094 94 (r2=0.94 p<0.00 p000 00 r2=0.931 r2093 93 (r2=0.93 2. 12. 14. r2=0.872 r2087 87 (r2=0.87 r2=0.821 r2082 82 (r2=0.82 r2=0.94 r209 (r2=0.9 p<0.0 p00 r2=0.93 r2=0.87 r208 (r2=0.8 r2=0.82 r2=0.9 r20 (r2=0. p<0. p0 r2=0.8 r2=0. (r2=0 p<0 r2=0 (r2= p< r2= (r2 (r

RESUMEN Las cuatro misiones de la Universidad hacen que esta tenga un papel importante en el desarrollo económico y social a través de la formación del capital humano. Entre las misiones, se encuentran la enseñanza y la investigación. La enseñanza debe llevarse a cabo por medio de la investigación para generar las bases del conocimiento y el desarrollo de este. Además, debe generar el uso del conocimiento, su preservación y difusión mediante la interacción con usuarios. Por eso, se indagó en: 1) la formación de los estudiantes universitarios de Encarnación con relación a la CTI; 2) el índice de universidades de Encarnación que realizan transferencia de conocimiento; 3) la relación entre las MIPYMES y las universidades de Encarnación. Metodológicamente, se trabajó con la metodología cuantitativa-método descriptivo. Se aplicó una encuesta a directivos de 4 universidades privadas de la ciudad. Los resultados dan cuenta de la falta de capital humano calificado en I+D+i dentro de las universidades estudiadas, hecho que dificulta la implementación de las oficinas de transferencia de conocimiento (OTRI) pues la formación relacionada a la investigación e innovación se ven limitadas al no desarrollarse en todos los años de cursada, siendo esto, a nivel de grado y posgrado, además de la escasa actividad de vinculación con el medio. Estos hallazgos resaltan la limitada capacidad para generar nuevos conocimientos contextualizados a la realidad local y a su posterior aplicación eficiente.

ABSTRACT The four missions of the University give it an important role in economic and social development through the formation of human capital. Among the missions are teaching and research. Teaching must be carried out through research to generate the bases of knowledge and its development. It must also generate the use of knowledge, its preservation and dissemination through interaction with users. Therefore, we investigated: 1) the training of university students in Encarnación in relation to STI; 2) the index of universities in Encarnación that carry out knowledge transfer; 3) the relationship between MSMEs and universities in Encarnación. Methodologically, we worked with the quantitative methodology - descriptive method. A sur- vey was applied to managers of 4 private universities in the city. The results show the lack of qualified human capital in R+D+i within the universities studied, a fact that hinders the implementation of knowledge transfer offices (OTRI), since training related to research and innovation is limited because it is not developed in all the years of study, both at the undergraduate and graduate levels, in addition to the limited activity of linking with the environment. These findings highlight the limited capacity to generate new knowledge contextualized to the local reality and its subsequent efficient application.

RESUMEN La discriminación y las violencias basadas en género dirigidas en contra de la población LGBTIQ+ se han estructurado a través de los años en una sociedad heteronormativa, machista, patriarcal y religiosa, causando así graves violaciones a derechos humanos relacionada a factores de comisión de delitos como el homicidio, feminicidio y la tortura. Algo característico de la comisión de estos actos es la sistematicidad y el factor de diversidad sexual y de género por el cual se realizan, con el fin de adaptar un pensamiento conservador implementado en la sociedad, causando diferentes formas de discriminación, discursos de odio e interseccionalidad que afectan el pleno desarrollo y la garantía de una vida digna para la población LGBTIQ+. Debido a la zozobra generada en la población LGBTIQ+, y sumado a ello el rasgo histórico de esta violencia sistemática, resulta necesario e interesante abordar la perspectiva de los delitos de lesa humanidad desde un análisis de la diversidad sexual como factor indiscutible de que el género y las diversidades sexuales deben contar con una intervención y aplicación de las tipificaciones contempladas en el Estatuto de Roma, buscando que estos instrumentos internacionales se adapten plenamente a realidades sociales presentes, que han causado en la comunidad internacional preocupación y obligaciones para una plena garantía de derechos e igualdad social para la población LGBTIQ+.

ABSTRACT Discrimination and gender-based violence directed against the LGBTIQ+ population have been structured over the years in a heteronormative, sexist, patriarchal and religious society, thus causing serious violations of human rights related to factors in the commission of crimes such as homicide, feminicide and torture; Something characteristic of the commission of these acts is the systematicity and the factor of sexual and gender diversity by which they are carried out, in order to adapt a conservative thought implemented in society, causing different forms of discrimination, hate speech and intersectionality. that affect the full development and guarantee of a dignified life for the LGBTIQ+ population. Due to the anxiety generated in the LGBTIQ+ population, and added to this the historical feature of this systematic violence, it is necessary and interesting to address the perspective of crimes against humanity from an analysis of sexual diversity as an indisputable factor that gender and sexual diversities must have an intervention and application of the classifications contemplated in the Rome Statute, seeking that these international instruments fully adapt to present social realities and that have caused concern and obligations in the international community for a full guarantee of rights and social equality for the LGBTIQ+ population.

ABSTRACT Social technology is based around three axes: community, environmental protection and economic solidarity. The páramo itself is a vital ecosystem for water regulation as it is the source of water supplies for human consumption and performance of economic activities. This article intends to identify the limitations to apply social technology to the protection of the páramo in the central highlands of Ecuador, where processes of self-management, empowerment, participation, agreement-making, cooperation and pursuit for collective welfare have been observed. The methodology is quantitative within the framework of discourse analysis. The results show that, in order to reach a large agreement for the protection and recovery of the páramo, involving all of the communities settled in the area, it is necessary to overcome limitations mostly related to the lacking attention by the government in regards to basic utilities, management plans for conservation areas and studies for economic alternatives allowing communities to subsist in the lower zones, compromising not to extend their agricultural borders further into the highlands. This information helps strengthen natural resource management from a new perspective.

RESUMEN La tecnología social se fundamenta en tres ejes: la comunidad, el cuidado ambiental y la solidaridad económica. Por su parte, el páramo es un ecosistema vital en la regulación hídrica porque sustenta el suministro de agua para consumo humano y el desarrollo de actividades económicas. Este artículo se centra en identificar las limitaciones para aplicar los fundamentos de la tecnología social en la protección del páramo, ubicado en la Sierra central del Ecuador, lugar donde se observan procesos de autogestión, empoderamiento, participación, logro de acuerdos, cooperación y búsqueda del bienestar colectivo. La metodología es cualitativa, en el marco del análisis del discurso. Los resultados muestran que, para que exista un gran acuerdo de protección y recuperación del páramo, entre todas las comunidades asentadas en esta zona, es necesario vencer limitaciones relacionadas, principalmente, con la falta de atención por parte del gobierno en temas de servicios básicos, planes de manejo para áreas de conservación y estudio de alternativas económicas que permitan a las comunidades subsistir en las zonas bajas y comprometerse a no ampliar la frontera agrícola hacia zonas altas. Esta información contribuye a fortalecer la gestión de recursos naturales desde una nueva perspectiva.

RESUMO A tecnologia social baseia-se em três eixos: a comunidade, o cuidado ambiental e a solidariedade econômica. O páramo é um ecossistema vital para a regulação hídrica pois ele fornece agua para o consumo humano e a realização de atividades económicas. Esse artigo focou-se na identificação das limitações para aplicar os fundamentos da tecnologia social para a proteção do páramo, situado na Sierra central de Equador, sítio onde pode-se observar processos de autogestão, empoeiramento, participação, efetuação de acordos, cooperação e procuração de um bem-estar coletivo. A metodologia é qualitativa, dentro do contexto da análise do discurso. Os resultados mostram que, para ter um acordo grande para a proteção e recuperação do páramo, com todas as comunidades estabelecidas na zona, é necessário vencer limitações relacionadas principalmente à falta de atenção do governo em relação à serviços básicos, planes de gestão de áreas de conservação e estudo de alternativas económicas que permitam que as comunidades possam subsistir nas zonas baixas, e comprometer-se a não estender a fronteira agrícola em direção às zonas altas. Essa informação contribui a fortalecer a gestão de recursos naturais com uma nova perspectiva.

Resumen (Objetivo) Aunque el uso de vídeos de aula no es un tópico novedoso en la formación inicial del profesorado de educación matemática infantil, todavía hay preguntas de investigación sin resolver asociadas, sobre todo, a criterios para seleccionar y analizar vídeos desde un enfoque didáctico y disciplinar. Desde esta perspectiva, la finalidad del artículo es diseñar y validar una rúbrica que sirva para este doble propósito. (Metodología) A partir de un paradigma de investigación cualitativo, se ha seguido un proceso 4x3, es decir, un método secuenciado en cuatro fases con tres pasos en cada una de ellas: 1) revisión, 2) creación, 3) contraste y evaluación, y 4) mejora. (Resultados) La versión definitiva de la rúbrica, denominada R4, consta de 28 ítems organizados en cuatro dimensiones: 1) rol docente, sobre la función que tiene cada docente en el aula; 2) respuesta del alumnado infantil en la tarea, sobre su actuación; 3) relaciones matemáticas, sobre el tipo de matemática; 4) recursos, sobre la gestión y uso de recursos-materiales humanos. Para cada dimensión se considera diversas subdimensiones, en total 16. (Conclusiones) Se concluye que la rúbrica R4 aborda aspectos fundamentales (rol docente, respuesta del alumnado infantil, relaciones matemáticas y recursos) en la labor docente de una maestra o maestro de educación infantil, lo cual permite analizar la práctica docente de un modo holístico y fundamentado.

Resumo (Objetivo) Embora o uso de vídeos em sala de aula não seja um tópico novo na formação inicial de professores de matemática da educação infantil, ainda há questões de pesquisa não resolvidas associadas, sobretudo, aos critérios de seleção e análise de vídeos a partir de uma abordagem didática e disciplinar. A partir dessa perspectiva, o objetivo do artigo é projetar e validar uma rubrica que atenda a essa dupla finalidade. (Metodologia) Com base em um paradigma de pesquisa qualitativa, foi seguido um processo 4x3, ou seja, um método sequenciado em quatro fases com três etapas em cada uma delas: 1) revisão, 2) criação, 3) contraste e avaliação, e 4) aprimoramento. (Resultados) A versão final da rubrica, denominada R4, consiste em 28 itens organizados em quatro dimensões: 1) papel do professor, sobre a função que cada professor tem na sala de aula; 2) resposta dos alunos à tarefa, sobre seu desempenho; 3) relações matemáticas, sobre o tipo de matemática; 4) recursos, sobre o gerenciamento e o uso de recursos humanosmateriais. Para cada dimensão são consideradas diversas subdimensões, totalizando 16. (Conclusões) Conclui-se que a rubrica R4 aborda os principais aspectos (função do professor, resposta dos alunos da educação infantil, recursos e relações matemáticas) no trabalho de ensino de um professor da educação infantil, o que permite uma análise holística e informada da prática de ensino.

Abstract (Objective) Although the use of classroom videos is not a new topic in the initial training of early childhood mathematics education teachers, there are still unresolved research questions associated, above all, with criteria for selecting and analyzing these videos from both a didactic and disciplinary approach. From this perspective, the purpose of this article is to design and validate a rubric that serves this dual purpose. (Methodology) Based on a qualitative research paradigm, a 4x3 process has been followed, that is, a method sequenced in four phases with three steps in each one of them: 1) Review; 2) Creation; 3) Contrast and Evaluation; and 4) Improvement. (Results) The final version of the rubric, called R4, consists of 28 items organized in four dimensions: 1) Teaching role, on the role of the teacher in the classroom; 2) Response of children in the task to his/her performance; 3) Mathematical relations, on the type of mathematics; 4) and Resources, on the management and use of human resources and materials. For each dimension, several subdimensions are considered, 16 in total. (Conclusions) It is concluded that the R4 rubric addresses fundamental aspects (Teaching role, Childrens’ response, Mathematical relations and Resources) in the teaching work of an early childhood education teacher, which allows analyzing the teaching practice in a holistic and justified way.

Abstract Introduction: Friendship positively influences human development. However, people with disabilities face difficulties in building and maintaining this bond. This study aims to explore and analyze the knowledge networks in the literature on friendship and disabilities from 2017 to 2022. Method: Using PRISMA criteria, the search was conducted in the Scopus and Web of Science databases. VOSviewer and Pajek software were used to construct and analyze the networks. Results: Sixty-eight articles were analyzed. The United States leads in publications, but the United Kingdom is more influential in the network. The main research areas are autism spectrum disorder, intellectual disability, social inclusion, social skills, and violence against people with disabilities. Influential documents address thematic analysis in psychology, and friendship among individuals with autism spectrum disorder and intellectual disability. Conclusions: Knowledge maps and network analysis help explore the literature, allowing an understanding of trends, the foundational intellectual structure, and scientific correlations.

Resumo Introdução: A amizade influencia positivamente o desenvolvimento humano. Todavia, pessoas com deficiencia enfrentam dificuldades para construir e manter esse vínculo. Este estudo objetiva explorar e analisar as redes de conhecimento da literatura sobre amizade e deficiencia de 2017 a 2022. Método: Utilizando critérios Prisma, a busca foi realizada nas bases de dados Scopus e Web of Science. Os softwares VOSviewer e Pajek foram usados para construir e analisar as redes. Resultados: Foram analisados 68 artigos. Os Estados Unidos lideram em publicaçoes, entretanto o Reino Unido é mais influente na rede. As principais investigaçoes na área sao: transtorno do espectro autista, deficiencia intelectual, inclusao social, habilidades sociais e violencia contra a pessoa com deficiencia. Documentos influentes abordam análise temática em psicologia, amizade de pessoas com transtorno do espectro autista e deficiencia intelectual. Conclusões: Os mapas de conhecimento e análise de redes ajudam a explorar a literatura, o que permite compreender tendencias, estrutura intelectual base e correlações científicas.

Abstract Introduction: The River Tambo basin is one of the main hydrographic systems of the Peruvian western watershed, being a source of development for agriculture, agroindustry, livestock, and domestic use in the Tambo Valley and Arequipa City. Objective: To analyze the structure of macroinvertebrates in River Tambo, Perú and assess the water quality through this community. Methods: Five sampling events were conducted between December 2018 and November 2019 in 12 stations, using a Surber net (500 μm). Macroinvertebrates were identified at a family level. To assess community structure, richness, Simpson’s dominance index (D), Pielou’s evenness (J’), and true diversity of order 1 were determined. A nMDS based on the Bray-Curtis index was used to evaluate dissimilarity. To check for differences in community structure, ANOSIM and two-way MANOVA were used. SIMPER was used to establish family contribution to sample similarity. Relations between physicochemical and biological variables were determined by CCA. ABI index was applied to assess ecological quality. Results: 32 families were recognized, being the most abundant: Baetidae, Chironomidae, Leptohyphidae, Simuliidae, Hydroptilidae, and Elmidae. The middle and low zones of the basin showed the highest and lowest diversity respectively. There were significant differences (P < 0.05) in the community structure indices among the 12 stations differed. There was a higher similarity among the 12 stations in December. ABI scores increased from the low to the middle part of the river, which showed the highest ecological quality. Conclusion: Macroinvertebrate communities from River Tambo reflect ecosystem conditions. Environments impacted by human activities show lower diversity and ecological quality, due to the structure, habitat, and water quality of the river being altered.

Resumen Introducción: La cuenca del rio Tambo es uno de los principales sistemas hidrográficos de la vertiente occidental del Perú y fuente de desarrollo para la agricultura, agroindustria, ganadería y consumo doméstico en el valle de Tambo y la ciudad de Arequipa. Objetivo: Analizar la estructura de macroinvertebrados en el río Tambo, Perú y evaluar la calidad del agua a través de esta comunidad. Métodos: Entre diciembre del 2018 y noviembre del 2019 se realizaron cinco muestreos en 12 estaciones, empleando una red Surber (500 μm). Los macroinvertebrados se identificaron a nivel de familia. Se registró la riqueza, dominancia de Simpson, equidad de Pielou, y diversidad verdadera de orden 1, para evaluar la estructura de la comunidad. Para estimar la similitud, se utilizó nMDS (índice de Bray-Curtis). Para verificar si existen diferencias en la estructura comunitaria, se empleó MANOVA de dos vías y ANOSIM. Para establecer la contribución de las familias a la similitud entre muestras, se utilizó SIMPER. La relación entre variables fisicoquímicas y biológicas se determinó con ACC. Se aplicó el índice ABI para evaluar la calidad ecológica. Resultados: se reconocieron 32 familias, siendo las más abundantes: Baetidae, Chironomidae, Leptohyphidae, Simuliidae, Hydroptilidae y Elmidae. La mayor y menor diversidad se presentó en la parte media y baja de la cuenca respectivamente. Existieron diferencias significativas (P < 0.05) de los índices de estructura comunitaria entre las 12 estaciones. Se evidenció mayor similitud entre las 12 estaciones en diciembre. Los puntajes del índice ABI se incrementan de la parte baja del río a la media, que se presentó la mejor calidad ecológica. Conclusión: Las comunidades de macroinvertebrados del río Tambo reflejan el estado del ecosistema. Los ambientes con impacto por actividad humana registran menor diversidad y calidad ecológica, ya que se altera la estructura, hábitat y calidad de agua del río.