ABSTRACT Purpose: To describe the epidemiological and clinical profile of hospitalized patients with retinoblastoma in Brazil. Methods: Using data from the Hospital Cancer Registry of the Instituto Nacional de Câncer, patients with the morphological codes of retinoblastoma who were diagnosed between 2000 to 2018, aged 0–19 years, and followed up in registered hospitals (analytical cases) were selected. The relative and absolute frequencies of demographic, clinical, diagnostic, therapeutic, and outcome variables were described. Hospital performance indicators were calculated and compared between hospitals qualified and not qualified to treat pediatric oncology cases and between hospitals with different case volumes (<20, 20-75, >75 cases). Results: Of the 2,269 identified analytical cases from 86 institutions, 48% were from the Southeast, 54% were male, and 66% were aged <4 years. The proportion of missing data (NA) was too high for several variables. Approximately 84% of the patients were from the public health system, 40% had a positive family history, and 88% had unilateral involvement. The first treatment included surgery in 58.3% of the patients (NA=2), Approximately 36.6% of these patients achieved complete remission, 10.8% achieved partial remission, and 12.7% died (NA=59%). Hospital performance indicators were within the target in >90% of the patients. The median time between the first appointment and diagnosis (6 days, interquartile range [IQR] 1–14) was significantly lower and the median time to death was longer (343 days, IQR, 212-539) in high-volume hospitals (>75 cases) than in medium- and low-volume hospitals. Conclusions: Despite the high proportion of missing data, we found that the delay in diagnosis is due to prehospital factors. Additionally, there is a need for educational programs for healthcare professionals and families that emphasize early identification and referral to specialized centers. Future studies should focus on the impact of Hospital Cancer Registry data completeness on outcomes, causes of delay in diagnosis, regional inequalities, and barriers to accessing specialized services. Purpose Brazil Methods Câncer 200 2018 019 0 19 0–1 years selected demographic diagnostic therapeutic described <20, 20 (<20 2075, 2075 75, 75 20-75 >7 cases. . Results 2269 2 269 2,26 8 institutions 48 Southeast 54 male 66 4 < NA (NA 84 system 40 history 88 involvement 583 58 3 58.3 NA=2, NA2 NA=2 , (NA=2) 366 36 6 36.6 remission 108 10 10.8 127 12 7 12.7 NA=59%. NA59 NA=59% 59 (NA=59%) 90 >90 ( days IQR [IQR 1–14 114 1 14 343 (34 212539 212 539 212-539 highvolume volume (>7 medium lowvolume low Conclusions factors Additionally centers outcomes inequalities services 201 01 0– <20 (<2 207 20-7 > 226 26 2,2 5 58. NA= (NA=2 36. 10. 12. NA5 NA=59 (NA=59% 9 >9 1–1 11 34 (3 21253 21 53 212-53 (> <2 (< 20- 22 2, (NA= NA=5 (NA=59 1– 2125 212-5 (NA=5 212-

Resumen Marco contextual: La implantación de la Práctica Basada en la Evidencia (PBE) es esencial para la calidad de los cuidados de enfermería. Las acciones emprendidas por los líderes formales son esenciales para implantar la PBE, y es fundamental conocer sus percepciones. Objetivo: Conocer las percepciones de los líderes formales de enfermería sobre la PBE. Metodología: Estudio exploratorio descriptivo con enfoque cualitativo. Se realizaron entrevistas semiestructuradas a 17 líderes de tres hospitales portugueses. Los datos se analizaron mediante análisis de contenido y el programa MAXQDA Analytic Pro 2022. Se garantizaron los presupuestos éticos. Resultados: Surgieron dos temas con sus respectivas categorías − Conocimiento sobre la PBE (Concepto de la PBE, Impacto de la PBE en los resultados sanitarios y Autopercepción del conocimiento sobre la PBE); Papel en la aplicación de la PBE (comportamientos y características). Conclusión: Los líderes describieron su percepción del concepto de PBE y la relación del Impacto de la PBE con los resultados sanitarios, la necesidad de conocimientos y su inversión formativa, así como su papel en este proceso. Los futuros programas de formación deberían aplicarse en este ámbito.

Abstract Background: The implementation of Evidence-Based Practice (EBP) is critical to the quality of nursing care. Formal leaders play a crucial role in developing interventions to implement EBP, so it is important to understand their perceptions. Objective: To examine formal nurse leaders’ perceptions of EBP. Methodology: Descriptive exploratory study with a qualitative approach. Semi-structured interviews were conducted with 17 leaders from three Portuguese hospitals. Data were analyzed using content analysis and MAXQDA Analytics Pro 2022 software. All ethical principles were observed. Results: Two themes and their categories emerged − Knowledge of EBP (Concept of EBP, Impact of EBP on health outcomes, and Self-perception of the knowledge about EBP) and Role in EBP implementation (behaviors and characteristics). Conclusion: The leaders described their perception of the concept of EBP and the association between the impact of EBP and health outcomes, the need for knowledge, and the investment in training, as well as their role in this process. Future training programs should be implemented in this area.

Resumo Enquadramento: A implementação da Prática Baseada na Evidência (PBE) é crucial para a qualidade dos cuidados de enfermagem. As ações desenvolvidas pelos líderes formais são essenciais para implementar a PBE, tornando-se determinante conhecer as suas perceções. Objetivo: Conhecer as perceções de líderes formais de enfermagem sobre a PBE. Metodologia: Estudo descritivo exploratório com abordagem qualitativa. Foram realizadas entrevistas semiestruturadas a 17 líderes de três hospitais portugueses. Os dados foram analisados através de análise de conteúdo e do software MAXQDA Analytics Pro 2022. Salvaguardados os pressupostos éticos. Resultados: Emergiram dois temas com respetivas categorias − Conhecimento sobre PBE (Conceito de PBE, Impacto da PBE nos resultados em saúde e Autoperceção do conhecimento sobre PBE); Papel na implementação da PBE (comportamentos e caraterísticas). Conclusão: Os líderes descreveram a sua perceção sobre o Conceito de PBE e a relação do Impacto da PBE com resultados em saúde, a necessidade de conhecimento e o seu investimento formativo, bem como o seu papel neste processo. Futuros programas formativos deverão ser implementados nesta área.

Abstract: Healthcare buildings can be complicated to navigate, causing patients to experience stress and lose time if not adequately planned. This study aims to identify the relationship between the spatial layout in healthcare buildings and wayfinding for users, by utilizing Behavioral Sequence Analysis (BSA) and Space Syntax through Immersive Virtual Reality (iVR). The methodology is based on behavioral and spatial data and was tested by using the experimental setups in VR environments. Space syntax analysis is applied to collect spatial data. Experiments were conducted by assigning wayfinding tasks in virtual hospitals with various plan configurations. Behavioral data obtained from BSA was associated with the spatial data driven by the space syntax analysis to gain a comprehensive understanding of the participants' wayfinding behavior. The results indicate that the semi-centralized floor plan layout with high visibility levels performs better in wayfinding while the decentralized layout with low visibility values performs worse.

Resumen: Los edificios de atención médica pueden ser complicados de navegar, causando estrés y pérdida de tiempo a los pacientes si no están planificados adecuadamente. Este estudio busca identificar la relación entre la disposición espacial en estos edificios y la orientación de los usuarios, utilizando Análisis de Secuencia Comportamental (BSA) y Sintaxis Espacial a través de Realidad Virtual Inmersiva (iVR). La metodología se basa en datos comportamentales y espaciales, probada en configuraciones experimentales en entornos de iRV. El análisis de sintaxis espacial se emplea para recopilar datos. Se realizaron experimentos con tareas de orientación en hospitales virtuales con diversas configuraciones de plano. Los datos conductuales del BSA se asociaron con los datos espaciales, obteniendo una comprensión completa del comportamiento de orientación. Los resultados indican que la disposición semi-centralizada con alta visibilidad es más eficaz en la orientación, mientras que la distribución descentralizada con baja visibilidad lo es menos.

Abstract The organizational climate is related to the degree of motivation of its employees. This perception is essentially felt, it is neither seen nor touched, but it is real. This study aims to identify difficulties and potentialities related to the organizational climate of the nursing staff at a public hospital in the Federal District. Methodologically, a descriptive and exploratory study was carried out characterized by a qualitative approach. The thematic content analysis led to three interpretative dimensions: environment and working conditions; communication, interpersonal relationship and work flows; motivation to improve the work environment. The results indicate a deficit of human resources, scarcity of material resources, supplies, precarious physical structure, in addition to interpersonal relationship problems, such as the (de)valuation of professional nurses and nursing. The challenges posed to managers go beyond the technical and structural dimension, the technological complexity of equipment without maintenance, as it unfolds through the human dimension, feelings and unmet needs (of appreciation) of nursing, which needs to be cared for, valued, heard and seen in their care process. employees felt touched real District Methodologically approach dimensions conditions communication flows resources supplies structure problems devaluation de valuation dimension maintenance appreciation for valued process

Resumo O ambiente organizacional está relacionado com o grau de motivação de seus colaboradores. Essa percepção é essencialmente sentida, não se vê e nem se toca, mas tem uma existência real. Este estudo objetiva identificar as dificuldades e potencialidades relacionadas ao clima organizacional dos servidores de enfermagem de um hospital público do Distrito Federal. Metodologicamente foi realizado um estudo descritivo e exploratório caracterizado por uma abordagem qualitativa. A análise de conteúdo temática conduziu a três dimensões interpretativas: ambiente e condições de trabalho; comunicação, relacionamento interpessoal e fluxos de trabalho; e motivação para a melhoria do ambiente de trabalho. Os resultados apontam para um déficit de recursos humanos, escassez de recursos materiais, insumos, estrutura física precária, além de problemas de relacionamento interpessoal, como a (des)valorização do profissional enfermeiro e da enfermagem. Os desafios postos para os gestores estão para além da dimensão técnica e estrutural, da complexidade tecnológica dos equipamentos sem manutenção, desdobra-se pela dimensão humana, pelos sentimentos e pelas necessidades não atendidas (de valorização) da enfermagem, que precisa ser cuidada, valorizada, ouvida e vista no seu processo de cuidar. colaboradores sentida toca real Federal qualitativa interpretativas trabalho comunicação humanos materiais insumos precária desvalorização des valorização estrutural manutenção desdobrase desdobra humana cuidada valorizada cuidar

Resumen Estudio de tipo cualitativo que explora las perspectivas y experiencias de un grupo de mujeres mexicanas que vivieron la atención institucionalizada del parto en la primera y segunda ola de la pandemia por COVID-19. A través de un guión semiestructurado se entrevistó a nueve mujeres que vivieron la experiencia de la atención del parto entre marzo y octubre de 2020, en hospitales públicos y privados de la ciudad de San Luis Potosí, en México. Bajo la propuesta de análisis de la teoría fundamentada, se identificó que las estrategias sanitarias implementadas en el marco de la pandemia, trajeron consigo un retroceso en la garantía del parto humanizado, las mujeres se narraron desconfiadas en los protocolos que siguió el personal para la atención de sus partos en los hospitales del sector público y muy confiadas en los que se implementaron en el sector privado. La realización de cesáreas sin una justificación clara emergió como una constante, igual que la separación temprana de los binomios. Continúa frágil la disposición y el convencimiento del personal sanitario y las instituciones para garantizar, proteger y defender el derecho de las mujeres a vivir el parto libre de violencia. Persisten resistencias para repensar la atención del parto desde un paradigma no biomédicalizante. COVID19. COVID19 COVID 19. 19 COVID-19 2020 Potosí México fundamentada humanizado privado constante binomios garantizar violencia biomédicalizante COVID1 1 COVID-1 202 COVID- 20 2

Abstract This is a qualitative study that explores the perspectives and experiences of a group of Mexican women who experienced institutionalized childbirth care in the first and second waves of the COVID-19 pandemic. Through a semi-structured script, nine women who experienced childbirth care were interviewed between March and October 2020 in public and private hospitals in the city of San Luis Potosí, Mexico. Under the Grounded Theory analysis proposal, it was identified that the health strategies implemented during the pandemic brought with them a setback in the guarantee of humanized childbirth. Women described themselves as distrustful of the protocols that personnel followed to attend to their births in public sector hospitals and very confident in those implemented in the private sector. The intervention of cesarean sections without a clear justification emerged as a constant, as did early dyad separation. Healthcare personnel’s and institutions’ willingness and conviction to guarantee, protect and defend the right of women to experience childbirth free of violence remain fragile. Resistance persists to rethink childbirth care from a non-biomedicalizing paradigm. COVID19 COVID 19 COVID-1 semistructured semi structured script 202 Potosí Mexico proposal constant separation personnels s institutions fragile nonbiomedicalizing non biomedicalizing paradigm COVID1 1 COVID- 20 2

Abstract This study aimed to analyze the role of nurses in hospital management in the face of COVID-19. The study had a qualitative, descriptive, and exploratory approach. The setting was a hospital that was completely transformed to care for patients with COVID-19. At the time of data collection, ten nurses managed the services, and all participated in the semi-structured interview. After thematic analysis, the data were presented in three categories, representing the elements of Donabedian’s triad: structure, process, and result. Category 1 highlighted the hospital structure reconfiguration based on material and people management; category 2 addressed the work process restructuring to achieve goals with safety and quality; and category 3 focused on nurses’ experiences in describing the results achieved and expected. The analysis highlighted the importance of teamwork, involvement, and adaptation of managers in the face of the challenges of a new and life-threatening disease, scarce resources, and the complexity of human relationships in the crisis. In transformational leadership, these nurses encouraged behavior change, professional growth, and resilience. COVID19. COVID19 COVID 19. 19 COVID-19 qualitative descriptive approach collection services semistructured semi structured interview categories Donabedians Donabedian s triad result quality expected teamwork involvement lifethreatening life threatening disease resources crisis leadership change growth resilience COVID1 COVID-1 COVID-

Resumo Objetivou-se analisar a atuação dos enfermeiros na gestão hospitalar frente à COVID-19. O estudo teve uma abordagem qualitativa, do tipo descritivo e exploratório. O cenário foi um hospital que se transformou totalmente para atendimento de pacientes com COVID-19. No momento da coleta de dados, dez enfermeiros estavam à frente da gestão dos serviços, e todos participaram da entrevista semiestruturada. Os dados, após análise temática, foram apresentados em três categorias representativas dos elementos da tríade de Donabedian, ou seja, estrutura, processo e resultado. A categoria 1 realçou a reconfiguração da estrutura hospitalar a partir da gestão de materiais e das pessoas; a categoria 2 abordou a reestruturação do processo de trabalho para alcance das metas com segurança e qualidade; e a categoria 3 focou nas experiências dos enfermeiros na descrição dos resultados alcançados e esperados. A análise evidenciou a importância do trabalho em equipe, do envolvimento e da adaptação do gestor diante dos desafios da doença nova e ameaçadora da vida, dos recursos escassos e da complexidade das relações humanas na crise. Na liderança transformacional esses enfermeiros incentivaram a mudança de comportamento, o crescimento profissional, e resiliência. Objetivouse Objetivou COVID19. COVID19 COVID 19. 19 COVID-19 qualitativa exploratório dados serviços semiestruturada temática Donabedian seja resultado pessoas qualidade esperados equipe vida crise comportamento profissional resiliência COVID1 COVID-1 COVID-

Abstract Objective: To evaluate exclusive breastfeeding at discharge and hospital length-of-stay in pre-term infants undergoing or not the Kangaroo-Mother Care Method (KMC). Methods: A retrospective cohort study was conducted including preterm infants < 1800 g admitted to the neonatal unit of a KMC reference center. The infants were grouped into the KMC group and the non-KMC group. Multiple logistic and Poisson regressions were performed to evaluate the association between the KMC and two outcomes, exclusive breastfeeding at discharge, and hospital length-of-stay, adjusted for potential confounders. Results: 115 mother-infant dyads were included, 78 in the KMC group and 37 in the non-KMC group. In the bivariate analysis, the KMC group had a lower prevalence of maternal adverse conditions (6% vs. 32%, p < 0.001), a higher number of prenatal visits (median 6 vs. 3.5, p < 0.001), higher gestational ages (median 32 vs. 31 weeks, p < 0.05), higher birth weights (median 1530 vs. 1365 g, p < 0.01), a lower prevalence of necrotizing enterocolitis (3.8% vs. 16.2%, p < 0.05), parenteral nutrition (50% vs. 73%, p < 0.05), and deep vascular access (49.7% vs. 78.4%, p < 0.01), a higher prevalence of exclusive breastfeeding (65% vs. 8%, p < 0.001) and a shorter length of hospital stay (median 28 vs. 42 days, p < 0.001). In the multiple regression analysis, the KMC group was 23 times more likely to be exclusively breastfed at discharge (OR = 23.1; 95% CI = 4,85–109,93) and had a 19% reduction in the hospital length-of-stay (IDR = 0.81; 95% CI = 0.76–0.86) compared to the non-KMC group. Conclusions: The KMC is associated with better short-term neonatal outcomes and should be encouraged in all Brazilian maternity hospitals. Objective lengthofstay pre term KangarooMother Kangaroo Mother KMC. . (KMC) Methods 180 center nonKMC non lengthofstay, stay, confounders Results 11 motherinfant mother infant included 7 3 analysis 6% (6 vs 32% 0.001, 0001 0.001 , 0 001 median 35 5 3.5 weeks 0.05, 005 0.05 05 0.05) 153 136 0.01, 0.01 01 0.01) 3.8% 38 8 (3.8 162 16 2 16.2% 50% 50 (50 73 73% 49.7% 497 49 (49.7 784 4 78.4% 65% 65 (65 8% days 0.001. OR 23.1 231 1 95 4,85–109,93 48510993 85 109 93 19 IDR 0.81 081 81 0.76–0.86 076086 76 86 Conclusions shortterm short hospitals (KMC 18 ( 000 0.00 00 3. 0.0 15 13 3.8 (3. 16.2 (5 49.7 (49. 78.4 23. 9 4,85–109,9 4851099 10 0.8 08 0.76–0.8 07608 0. (3 16. 49. (49 78. 4,85–109, 485109 0.76–0. 0760 (4 4,85–109 48510 0.76–0 076 4,85–10 4851 0.76– 07 4,85–1 485 0.76 4,85– 48 0.7 4,85 4,8 4,

Abstract Objective: To estimate the direct costs of treating excess body weight in children and adolescents attending a public children’s hospital. Methods: This study analyzed the costs of the disease within the Brazilian Unified Health System (SUS) for 2,221 patients with excess body weight using a microcosting approach. The costs included operational expenses, consultations, and laboratory and imaging tests obtained from medical records for the period from 2009 to 2019. Healthcare expenses were obtained from the Table of Procedures, Medications, Orthoses/Prostheses, and Special Materials of SUS and from the hospital’s finance department. Results: Medical consultations accounted for 50.6% (R$703,503.00) of the total cost (R $1,388,449.40) of treatment over the period investigated. The cost of treating excess body weight was 11.8 times higher for children aged 5–18 years compared to children aged 2–5 years over the same period. Additionally, the cost of treating obesity was approximately 4.0 and 6.3 times higher than the cost of treating overweight children aged 2–5 and 5–18 years, respectively. Conclusion: The average annual cost of treating excess body weight was R$138,845.00. Weight status and age influenced the cost of treating this disease, with higher costs being observed for individuals with obesity and children over 5 years of age. Additionally, the important deficit in reimbursement by SUS and the small number of other health professionals highlight the need for restructuring this treatment model to ensure its effectiveness, including a substantial increase in government investment. Objective childrens s hospital Methods (SUS 2221 2 221 2,22 approach 200 2019 Procedures Medications OrthosesProstheses Orthoses Prostheses Orthoses/Prostheses hospitals department Results 506 50 6 50.6 R$703,503.00 R70350300 R 703 503 00 (R$703,503.00 $1,388,449.40 138844940 1 388 449 40 investigated 118 11 8 11. 518 18 5–1 25 2– Additionally 4 0 4. 63 3 6. respectively Conclusion R13884500 138 845 R$138,845.00 effectiveness investment 222 22 2,2 20 201 50. R$703,503.0 R7035030 70 (R$703,503.0 $1,388,449.4 13884494 38 44 51 5– R1388450 13 84 R$138,845.0 2, R$703,503. R703503 7 (R$703,503. $1,388,449. 1388449 R138845 R$138,845. R$703,503 R70350 (R$703,503 $1,388,449 138844 R13884 R$138,845 R$703,50 R7035 (R$703,50 $1,388,44 13884 R1388 R$138,84 R$703,5 R703 (R$703,5 $1,388,4 1388 R138 R$138,8 R$703, R70 (R$703, $1,388, R13 R$138, R$703 R7 (R$703 $1,388 R1 R$138 R$70 (R$70 $1,38 R$13 R$7 (R$7 $1,3 R$1 R$ (R$ $1, $1 $

Resumo Fundamento Análises em grandes registros apontam desfechos desfavoráveis para mulheres submetidas à cirurgia de revascularização do miocárdio (CRM), enquanto estudos randomizados sofrem com a falta de representatividade. Objetivo Comparar os resultados hospitalares ajustados entre homens e mulheres submetidos à CRM. Métodos Entre julho de 2017 e junho de 2019, 3991 pacientes foram submetidos à CRM primária isolada, tanto de forma eletiva como de urgência, em 5 hospitais de estado de São Paulo, Brasil. Para equilibrar as diferenças entre homens e mulheres, as populações foram ajustadas utilizando o Propensity Score Matching. Os desfechos considerados para análise foram os utilizados pelo STS Adult Database. As análises foram conduzidas no software R, considerando significância valores de p < 0,05. Resultados Após o Propensity Score Matching (1:1), cada grupo incluiu 1089 pacientes. Em relação às variáveis intraoperatórias os homens apresentaram maior tempo de CEC (p<0,001), tempo cirúrgico (p<0,001), número de anastomoses distais (p<0,001) e uso de enxertos arteriais. Em relação aos desfechos as mulheres apresentaram maior incidência de infecção de ferida profunda (p=0,006), tempo prolongado na Unidade de Terapia Intensiva (p=0,002), maior necessidade do uso de balão intraórtico (p=0,04), maior taxa de transfusão sanguínea (p<0,001), maior readmissão hospitalar em até 30 dias após a cirurgia (p=0,002) e maior taxa de óbitos (p=0,03). Conclusões Apesar dos homens terem apresentado um maior tempo de CEC, maior número de enxertos arteriais e maior número de anastomoses distais, os resultados imediatos após CRM foram piores em mulheres. CRM, , (CRM) representatividade 201 2019 399 isolada urgência Paulo Brasil Database R 005 0 05 0,05 11, 11 1 (1:1) 108 p<0,001, p0001 p<0,001 001 (p<0,001 p=0,006, p0006 p=0,006 006 (p=0,006) p=0,002, p0002 p=0,002 002 p=0,04, p004 p=0,04 04 (p=0,04) 3 (p=0,002 p=0,03. p003 p=0,03 . 03 (p=0,03) (CRM 20 39 00 0,0 (1:1 10 p000 p<0,00 (p<0,00 p=0,00 (p=0,006 p00 p=0,0 (p=0,04 (p=0,00 (p=0,03 2 0, (1: p<0,0 (p<0,0 p0 p=0, (p=0,0 (1 p<0, (p<0, p=0 (p=0, ( p<0 (p<0 p= (p=0 p< (p< (p= (p

Abstract Background Analyses of extensive registries indicate adverse outcomes for women undergoing coronary artery bypass grafting (CABG) surgery, while randomized studies often lack representativeness. Objective To compare adjusted hospital outcomes between men and women undergoing CABG. Methods From July 2017 to June 2019, 3991 patients underwent primary isolated CABG, both electively and urgently, in 5 hospitals in the state of São Paulo, Brazil. To mitigate demographic differences between men and women, populations were adjusted using propensity score matching (PSM). The outcomes considered for analysis were those used by the STS Adult Database. The analyses were performed using R software, with a significance set at p<0.05. Results After PSM (1:1), each group included 1089 patients. Regarding intraoperative variables, men exhibited longer cardiopulmonary bypass (CPB) time (p<0.001), surgical time (p<0.001), a higher number of distal anastomoses (p<0.001), and increased use of arterial grafts. Regarding outcomes, women had a higher incidence of deep sternal wound infection (p=0.006), prolonged Intensive Care Unit stay (p=0.002), increased need for an intra-aortic balloon pump (p=0.04), higher blood transfusion rates (p<0.001), higher 30-day hospital readmission rates after surgery (p=0.002) and higher mortality rate (p=0.03). Conclusions Although men had longer CPB times, a greater number of arterial grafts, and a greater number of distal anastomoses, immediate results after CABG were poorer in women. (CABG representativeness 201 2019 399 urgently Paulo Brazil PSM. . (PSM) Database software p005 p 0 05 p<0.05 11, 11 1 , (1:1) 108 variables (CPB p<0.001, p0001 p<0.001 001 (p<0.001) grafts p=0.006, p0006 p=0.006 006 (p=0.006) p=0.002, p0002 p=0.002 002 intraaortic intra aortic p=0.04, p004 p=0.04 04 (p=0.04) 30day day 30 (p=0.002 p=0.03. p003 p=0.03 03 (p=0.03) times 20 39 (PSM p00 p<0.0 (1:1 10 p000 p<0.00 00 (p<0.001 p=0.00 (p=0.006 p=0.0 (p=0.04 3 (p=0.00 (p=0.03 2 p0 p<0. (1: (p<0.00 p=0. (p=0.0 p<0 (1 (p<0.0 p=0 (p=0. p< ( (p<0. p= (p=0 (p<0 (p= (p< (p

Drug poisoning is an important area of study in South Africa as a treatable cause of mortality. While research has been conducted on poisoning, there is a paucity of literature on the availability of antidotes in South Africa. The objectives of this study were to assess the availability of antidotes in selected teaching hospitals in the Southern Gauteng City-Region and to explore doctors' experiences of antidote supply. The availability of antidotes in the emergency departments (EDs) and pharmacies was assessed and recorded using a data sheet that was completed in person at each of the teaching hospitals. A questionnaire exploring experiences of antidote supply was distributed to 126 doctors working in the EDs. Our results indicate that N-acetylcysteine, atropine, diazepam, clonazepam, sodium bicarbonate, vitamin K, calcium gluconate, naloxone, ethanol, and pyridoxine were present in all EDs; activated charcoal was present in 80%; lorazepam, glycopyrrolate, and calcium chloride in 60%; freeze-dried plasma in 40%; glucagon and desferrioxamine in 20%; and fresh frozen plasma, hydroxocobalamin, sodium nitrite, sodium thiosulfate, sodium calcium edetate, and intralipid were not present in any of the EDs. Doctors reported organophosphate poisoning and paracetamol overdose as the most common drug poisonings (81.7% and 14.3% of 126 respondents, respectively). Most doctors experienced no supply issues for N-acetylcysteine, calcium gluconate, sodium bicarbonate, or pyridoxine (85.7%, 83.3%, 87.3%, and 75.4% of 126 respondents, respectively). The antidotes to the most common poisonings reported by doctors were present in all EDs. However, concerns were raised about consistency of supply, which will be an important avenue for further research. SIGNIFICANCE: • These findings highlight the lack of uniform availability of antidotes to common and critical drug poisonings in emergency departments. • The experiences of doctors in Gauteng concerning the most commonly encountered poisonings contrast with existing literature from South Africa, suggesting regional differences within the country.

BACKGROUND. Pathology of the hand causes functional impairment, with downstream effects for patient occupation, and consequently presents a socioeconomic burden. Investigation of the epidemiology of hand pathology in KwaZulu-Natal (KZN) can help reduce the burden of disease. Identifying where the greatest need is can direct patient awareness initiatives, medical training and appropriate allocation of resources. OBJECTIVES. To establish the prevalence of hand pathology at regional hospitals that offer orthopaedic services in KZN, to describe the patients most commonly affected by these pathologies and to identify the most common pathologies. METHODS. A cross-sectional investigation of hospital records and charts of patients presenting for orthopaedic care across all 10 regional hospitals in KZN that offer orthopaedic services was undertaken for 1 week's duration (June 2022). Patients were categorised into hand pathology (HP) and general orthopaedic pathology (OP) groups, which were each subdivided into trauma and non-trauma subgroups. Demographic details were collected for all patients. For HP patients, additional detail was collected regarding diagnosis, mechanism, admission and management. The prevalence of HP was calculated as a factor of all orthopaedic presentations. RESULTS. During the investigation, 2 335 patients presented to orthopaedic services. HP represented 21% of these cases. The majority (17%, 406/2 335) were related to trauma and represented 23% of all the traumatic orthopaedic presentations. Distal radius (DR) fractures were the most common hand injury (46%, 188/406) and a large proportion of trauma to the bony elements of the hand were open injuries (23%, 93/406). The remainder of HP cases comprised the non-traumatic group (4%, 91/2 335) and were predominantly infections (68%, 62/91), and many patients with non-traumatic hand pathology required surgery (60%, 55/91) and admission (56%, 52/91). CONCLUSION. HP represents approximately one-fifth of all orthopaedic presentations to regional health facilities in KZN offering orthopaedic care, and close to a quarter of orthopaedic trauma occurs in the hand. Based on these findings, targeted efforts to improve community awareness of precautions against trauma to the hand, osteopaenia and hand hygiene are suggested as preventive measures. Medical training should emphasise the appropriate management of DR fractures and hand infections, and resources should be differentially allocated to the management of these debilitating HPs to decrease the burden of disease.

Abstract Objective: The use of dupilumab in children with atopic dermatitis (AD) demonstrated clinical efficacy in clinical trials. Nevertheless, real-world evidence is still limited. We aim to provide data on this matter regarding a Portuguese pediatric population. Methods: Retrospective analysis of patients with AD below the age of 18 treated with dupilumab in two Portuguese hospitals. Data regarding previous therapies, activity scores, and adverse reactions were collected. Results: Thirty patients were included in the analysis (19 male patients, 63%), with a median age of 14 years (2-17 years). The median follow-up after starting treatment was 80 weeks. The median baseline Eczema Area and Severity Index (EASI) score was 32.3. Sixty percent of patients achieved EASI-90 and 77% EASI-75 at week 16 (n = 30); 79% EASI-90 and 92% EASI-75 at week 52 (n = 24); 64% EASI-90 and 82% EASI-75 at week 104 (n = 11); and 75% EASI-90 and 100% EASI-75 at week 132 (n = 4). Regarding adverse reactions, four patients (12%) presented facial erythema and two patients had eosinophilia above 2000/μL and conjunctivitis. In five patients (17%), there was a need for a dose increase, with treatment failure occurring in two patients (7%). Conclusion: Our data corroborated the evidence from clinical trials, highlighting the maintained efficacy and adequate safety profile of dupilumab in this age group.

Resumo Objetivo: O uso de dupilumab em crianças com dermatite atópica (DA) demonstrou eficácia clínica em ensaios clínicos. No entanto, a evidência do mundo real é ainda limitada. Este trabalho pretende fornecer dados relativos a este domínio, numa população pediátrica portuguesa. Métodos: Análise retrospetiva de doentes com DA com idade inferior a 18 anos, tratados com dupilumab, em dois hospitais portugueses. Foram recolhidos dados sobre terapêuticas prévias, scores de atividade e reações adversas. Resultados: Trinta doentes foram incluídos na análise (19 doentes do sexo masculino, 63%), com uma mediana de idades de 14 anos (2-17 anos). O seguimento mediano após o início do tratamento foi de 80 semanas. O score EASI basal mediano foi de 32,3. Sessenta por cento dos doentes alcançaram EASI-90 e 77% EASI-75 na semana 16 (n = 30); 79% EASI-90 e 92% EASI-75 na semana 52 (n = 24); 64% EASI-90 e 82% EASI-75 na semana 104 (n = 11); 75% EASI-90 e 100% EASI-75 na semana 132 (n = 4). Em relação a reações adversas, 4 doentes (12%) apresentaram eritema facial e 2 doentes eosinofilia superior a 2000/μL e conjuntivite. Em 5 doentes (17%), houve necessidade de aumento de dose, com falência do tratamento em 2 doentes (7%). Conclusão: O tratamento com Dupilumab na DA em idade pediátrica num ambiente de mundo real corroborou os dados dos ensaios clínicos, destacando a eficácia mantida e o perfil de segurança adequado neste grupo etário.

ABSTRACT Introduction Healthcare workers are exposed to many psychosocial risk factors. These have consequences at an individual and organizational level. Occupational health psychology applies the principles of psychology to the protection and promotion of workers' health and well-being. Here, it can act at the organizational level, with interventions that improve the working environment, and at the individual level, providing individuals with resources to deal with different types of settings. It was in this context that the occupational health service of a Lisbon hospital center decided to incorporate a psychologist into its team. Objective To describe a sample of health professionals referred for a psychology consultation, looking to generate hypotheses about characteristics that may constitute risk factors for needing this support. Methodology This is a descriptive study in which the sample corresponds to the group of workers that was referred to psychology, over seven months. The following symptoms were assessed: depressed mood, thoughts of death, anxiety, and sleep disturbances. All the data came from the clinical records of the psychologist and the occupational medicine physician, obtained through a clinical interview, and were previously anonymized. Results A total of 47 workers were followed in psychology appointments, corresponding to 1% of the hospital's population. The most prevalent professional group in the sample was operational assistants. Most of the workers reported having a previous diagnosis of psychopathology and 55% were still medicated. Only 15% of the workers identified work as a determining factor in their symptoms. Discussion There was a higher proportion of women compared to the overall population of the hospital, a finding that could be related to a greater risk inherent in the expectations imposed by society regarding the role of women as caregivers and the accumulation of functions in the social/family sphere. The "doctors" professional group is absent from the sample, hypothetically due to their lower attendance at occupational medicine consultations or the possible protection afforded to higher levels of education. Conclusions Contrary to the existing evidence, in this sample of health professionals from a hospital center in Lisbon, work was not the preponderant factor for the appearance of adverse health effects and determining follow-up in psychology consultations. In the future, the relationship between gender, educational level and professional group and increased risk of psychopathology should be tested more robustly.

RESUMO Introdução Os profissionais de saúde estão expostos a um elevado número de fatores de risco psicossociais. Estes têm consequências a nível individual e organizacional. A psicologia da saúde ocupacional aplica princípios da psicologia na proteção e promoção da saúde e bem-estar dos trabalhadores. Neste âmbito, pode atuar a nível da organização, com intervenções que melhorem o ambiente de trabalho, e a nível individual, dotando os indivíduos de recursos para lidar com diferentes tipos de ambientes. Foi neste contexto que um serviço de saúde ocupacional de um centro hospitalar de Lisboa decidiu integrar na sua equipa um psicólogo. Objetivo Descrever uma amostra de profissionais de saúde referenciados à consulta de psicologia, com vista a gerar hipóteses quanto a características que possam constituir fatores de risco para carecer desse apoio. Metodologia Trata-se de um estudo descritivo em que a amostra corresponde ao grupo de trabalhadores referenciado à consulta de psicologia ao longo de sete meses. Foram avaliados os sintomas humor deprimido, pensamentos de morte, ansiedade e alterações do sono. Todos os dados provêm dos registos clínicos do psicólogo e do médico do trabalho, obtidos através de entrevista clínica, tendo sido previamente anonimizados. Resultados Foram acompanhados em consulta de psicologia 47 trabalhadores, correspondendo a 1% da população do centro hospitalar. O grupo profissional mais prevalente na amostra foram os assistentes operacionais. A maioria dos trabalhadores referia já ter um diagnóstico prévio de psicopatologia e 55% mantinham-se medicados. Apenas 15% dos trabalhadores identificavam o trabalho como fator determinante na sintomatologia. Discussão Verificou-se uma maior proporção do sexo feminino, em relação com a população global do centro hospitalar, um achado que poderá relacionar-se com um maior risco inerente às expectativas impostas pela sociedade relativamente ao papel da mulher como cuidadora e o acúmulo de funções na esfera social/familiar. Está ausente da amostra o grupo profissional “médicos”, hipoteticamente por uma menor afluência destes às consultas de medicina do trabalho ou eventual proteção conferida a níveis educacionais mais altos. Conclusões Ao contrário da evidência existente, nesta amostra de profissionais de saúde de um centro hospitalar de lisboa, o trabalho não foi o fator preponderante para o aparecimento de efeitos adversos na saúde e a determinar o seguimento em consulta de psicologia. No futuro, deve ser testada de forma mais robusta a relação entre género, nível educacional e grupo profissional e aumento do risco de psicopatologia.

Abstract The present work studies and analyzes six books of the sick and two books of the sick of the Hospital Juanino de Nuestra Señora de los Desamparados of the city of Tezcoco elaborated in the XVIII century; but it focuses its attention on three important epidemics that struck the local population in 1737 (Matlazahuatl), 1784 (Influenza) and 1813 (Typhus). These manuscripts have remained in historiographic oblivion and their analysis allows us to know the ages, origin and “sickness” that were treated in a hospital during the eighteenth century.

Resumen El presente trabajo estudia y analiza seis libros de enfermos y dos de enfermas del hospital juanino de Nuestra Señora de los Dolores, de la ciudad de Tezcoco, elaborados en el siglo XVIII. La atención estará centrada en tres importantes epidemias que azotaron a la población local en 1737 (matlazahuatl), en 1784 (influenza) y en 1813 (tifo). Dichos manuscritos han permanecido en el olvido historiográfico y su análisis permite conocer las edades, procedencia y “enfermad” que era atendida en un hospital durante el siglo XVIII.

Résumé Cet article étudie et analyse huit ouvrages rédigés au XVIIIème par des patients, dont deux par des femmes, provenant de l’Hôpital Nuestra Señora de los Dolores de la ville de Tezcoco, fondé par l’ordre des Frères de la Charité (Juaninos). Il se focalise sur trois épidémies importantes qui ont frappé la population locale en 1737 (Matlazahuatl), 1784 (grippe) et 1813 (typhus). Ces manuscrits sont restés dans l’oubli historiographique mais leur analyse nous offre des informations essentielles sur l’âge, la provenance et le type de maladie des personnes qui étaient prises en charge dans un hôpital au XVIIIème.

Abstract This article looks at the transition of a practical problem into one of knowledge, seeking to situate the first experiences of forerunners of psychiatry in the border area between Mexico and the United States, precisely at the time of an open struggle against drug dependence. Through career histories in hospitals, jails, and drug detoxification clinics, a context will be defined in which seven psychiatrists gained knowledge relative to the mentally ill in a region, which had psychiatric educational programs and institutions only by the end of the 20th century.

Resumen Este artículo contempla la transformación de un problema práctico en uno de conocimiento, por lo que busca situar las primeras experiencias de los precursores de la psiquiatría en el espacio fronterizo entre México y Estados Unidos, justo en el momento en que tenía lugar un combate abierto a la farmacodependencia. La historia de sus trayectorias en hospitales, cárceles y clínicas de desintoxicación de drogas definirá el contexto en que siete psiquiatras adquirieron un saber relativo a los enfermos mentales de una región que solo hasta concluir el siglo XX, contó con instituciones y programas educativos en psiquiatría.

Résumé Cet article cherche à démontrer comment un problème concret devient une question de connaissance, à travers l’exemple des premières expériences des pionniers de la psychiatrie dans la région frontalière du Mexique et des ÉtatsUnis, précisément au moment où éclatait une lutte ouverte contre la pharmacodépendance. En suivant le parcours de sept psychiatres travaillant au sein d’hôpitaux, de prisons et de cliniques de désintoxication, nous retracerons le contexte dans lequel ils ont acquis des connaissances significatives sur les maladies mentales, dans une région où les programmes et les établissements d’enseignement psychiatrique ne sont apparus qu’à la fin du XXe siècle.