Resumo Este artigo tem por objetivo apresentar e discutir o conjunto de pressões que, nos últimos 50 anos, vem produzindo um resultado de esvaziamento industrial na Região Metropolitana de São Paulo. Para tanto, formula e propõe a hipótese de trabalho da tripla pressão. Cada uma delas integra um conjunto causal diferente, associado a uma escala também diferente. As três pressões são: 1) desindustrialização em escala nacional; 2) formação da Macrometrópole Paulista em escala regional; 3) assédio do mercado imobiliário para a reconversão de uso em áreas industriais em escala local. Nossos resultados apontam para o diagnóstico de que o esvaziamento industrial que é de longo prazo no município de São Paulo pode estar se espraiando para o seu entorno metropolitano. 5 anos tanto pressão diferente são 1 nacional 2 regional 3 local metropolitano

Abstract The main objective of this article is to present and discuss the set of pressures that, over the past fifty years, have led to an industrial decline in the São Paulo Metropolitan Region. The article formulates and proposes a working hypothesis called ‘triple pressure’. Each of such pressures integrates a different causal set associated with a different scale. The three pressures are deindustrialization on the national scale, the formation of the São Paulo Megalopolis on the regional scale, and the real estate market’s insistence on repurposing industrial areas on the local scale. Our results suggest that the industrial decline, which is a long-term process in the city of São Paulo, might be spreading to São Paulo’s metropolitan surroundings. years Region triple pressure. pressure . pressure’ scale markets market s longterm long term Paulos surroundings

Resumo O artigo tem como objetivo investigar um percurso singular de recepção e tradução das ideias de Antonio Gramsci no Brasil. Este trabalho visa reconstruir o pensamento político de Fernando Henrique Cardoso durante a ditadura militar e a transição democrática brasileira (1964-1988) tomando como fio condutor a interpretação e uso que esse autor faz das ideias de Antonio Gramsci ao longo do tempo para a análise da formação do Estado, das classes sociais e da política no Brasil. O texto desenvolve a hipótese da centralidade dos conceitos gramscianos no pensamento de Cardoso em três fases de refração gramsciana: i) entre 1964 e 1974, na tese da hegemonia dependente da burguesia no Brasil, ii) entre 1974 e 1983, na defesa do Estado brasileiro como “Príncipe Moderno” enquanto categoria para análise da coalizão agrário-industrial-militar no pós-1964, e iii) de 1983 a 1988, na formulação do transformismo autoritário-esclarecido como comportamento das elites econômicas e militares brasileiras diante da pressão pela democratização do regime. Os usos dos conceitos gramscianos em Cardoso são criativos em todos esses momentos. Isto é, o pensador brasileiro se inspira nos conceitos gramscianos para criar seu próprio léxico a ser utilizado na análise da política brasileira. O artigo explora, portanto, não apenas a recepção, mas também a tradução das ideias de Gramsci em Fernando Henrique Cardoso. Brasil 19641988 1988 (1964-1988 gramsciana i 196 ii 197 Príncipe Moderno agrárioindustrialmilitar agrário industrial pós1964, pós1964 pós 1964, pós-1964 iii 198 autoritárioesclarecido autoritário esclarecido regime momentos é explora portanto 1964198 (1964-198 19 pós196 pós-196 196419 (1964-19 1 pós19 pós-19 19641 (1964-1 pós1 pós-1 (1964- pós- (1964 (196 (19 (1 (

Résumé L’article vise à étudier un parcours unique de réception et de traduction des idées d’Antonio Gramsci au Brésil. Ce travail vise à reconstruire la pensée politique de Fernando Henrique Cardoso pendant la dictature militaire et la transition démocratique brésilienne (1964-1988), en prenant comme fil conducteur l’interprétation et l’utilisation par l’auteur des idées d’Antonio Gramsci au fil du temps pour analyser la formation de l’État, des classes sociales et de la politique au Brésil. Le texte développe l’hypothèse de la centralité des concepts gramsciens dans la pensée de Cardoso en trois phases de réfraction gramscienne : (i) entre 1964 et 1974, dans la thèse de l’hégémonie dépendante de la bourgeoisie au Brésil, (ii) entre 1974 et 1983, dans la défense de l’État brésilien en tant que « Prince modern » comme catégorie d’analyse de la coalition agraire-industrielle-militaire dans la période post-1964, et (iii) de 1983 à 1988, dans la formulation du transformisme autoritaire-éclairées comme comportement des élites économiques et militaires brésiliennes face à la pression pour la démocratisation du régime. L’utilisation par Cardoso des concepts gramsciens est créative à tous ces moments. En d’autres termes, le penseur brésilien s’inspire des concepts gramsciens pour créer son propre lexique d’analyse de la politique brésilienne. L’article explore donc non seulement la réception, mais aussi la traduction des idées de Gramsci chez Fernando Henrique Cardoso. Larticle L article dAntonio d Antonio Brésil 19641988, 19641988 1988 , (1964-1988) linterprétation l interprétation lutilisation utilisation lauteur auteur lÉtat, lÉtat État, État lhypothèse hypothèse i (i 196 lhégémonie hégémonie ii (ii 197 danalyse analyse agraireindustriellemilitaire agraire industrielle post1964, post1964 post 1964, post-1964 iii (iii 198 autoritaireéclairées autoritaire éclairées régime Lutilisation moments dautres autres termes sinspire s inspire 1964198 (1964-1988 19 post196 post-196 196419 (1964-198 1 post19 post-19 19641 (1964-19 post1 post-1 (1964-1 post- (1964- (1964 (196 (19 (1 (

Abstract This article aims to investigate a unique path in the reception and translation of Antonio Gramsci’s ideas in Brazil. This work attempts to reconstruct Fernando Henrique Cardoso’s political thought during the Brazilian military dictatorship and democratic transition (1964-1988), focusing on his interpretation and use of Antonio Gramsci’s ideas to analyze state formation, social classes and politics in Brazil. The paper argues that the Gramscian concepts are central to Cardoso’s political thought in three phases of Gramscian refraction: (i) between 1964 and 1974, in the thesis of the Brazilian bourgeoisie’s dependent hegemony; (ii) between 1974 and 1983, in the argument of the Brazilian state as the “Modern Prince” as a concept for the analysis of the agrarian-industrial-military coalition in the post-1964 period; and (iii) from 1983 to 1988, in the definition of the Brazilian economic and military elites’ behavior as a authoritarian-scletortic transformism in the face of the pressures for the democratization of the political regime. Cardoso’s uses of Gramscian concepts are creative at all these moments. That is, the Brazilian thinker draws on Gramscian concepts to create his own lexicon to employ in the analysis of Brazilian politics. The article therefore explores not only the reception, but also the translation of Gramsci’s ideas in Fernando Henrique Cardoso. Gramscis Gramsci s Brazil Cardosos Cardoso 19641988, 19641988 1988 , (1964-1988) formation refraction i (i 196 bourgeoisies bourgeoisie hegemony ii (ii 197 Modern Prince agrarianindustrialmilitary agrarian industrial post1964 post post-196 period iii (iii 198 elites authoritarianscletortic authoritarian scletortic regime moments is 1964198 (1964-1988 19 post196 post-19 196419 (1964-198 1 post19 post-1 19641 (1964-19 post1 post- (1964-1 (1964- (1964 (196 (19 (1 (

Resumen El artículo pretende investigar una trayectoria singular de recepción y traducción de las ideas de Antonio Gramsci en Brasil. Este artículo pretende reconstruir el pensamiento político de Fernando Henrique Cardoso durante la dictadura militar y la transición democrática brasileña (1964-1988), tomando como hilo conductor la interpretación y el uso que el autor hizo de las ideas de Antonio Gramsci a lo largo del tiempo para analizar la formación del Estado, las clases sociales y la política en Brasil. El texto desarrolla la hipótesis de la centralidad de los conceptos gramscianos en el pensamiento de Cardoso en tres fases de refracción gramsciana: (i) entre 1964 y 1974, en la tesis de la hegemonía dependiente de la burguesía en Brasil, (ii) entre 1974 y 1983, en la defensa del Estado brasileño como “Príncipe Moderno” como categoría de análisis de la coalición agrario-industrial-militar en el período posterior a 1964, y (iii) entre 1983 y 1988, en la formulación del transformismo autoritario-esclarecido como comportamiento de las élites económicas y militares brasileñas frente a la presión por la democratización del régimen. El uso que Cardoso hace de los conceptos gramscianos es creativo en todos estos momentos. En otras palabras, el pensador brasileño se inspira en los conceptos gramscianos para crear su propio léxico de análisis de la política brasileña. El artículo explora, por tanto, no sólo la recepción, sino también la traducción de las ideas de Gramsci en Fernando Henrique Cardoso. Brasil 19641988, 19641988 1988 , (1964-1988) gramsciana i (i 196 ii (ii 197 Príncipe Moderno agrarioindustrialmilitar agrario industrial iii (iii 198 autoritarioesclarecido autoritario esclarecido régimen momentos palabras explora tanto 1964198 (1964-1988 19 196419 (1964-198 1 19641 (1964-19 (1964-1 (1964- (1964 (196 (19 (1 (

Resumo Enquanto os primeiros estudos sobre estratégias eleitorais argumentam que o sistema adotado no Brasil incentiva o “voto pessoal” e a criação de redutos eleitorais geograficamente localizados, estudos mais recentes demonstram que a estratégia eleitoral mais efetiva é a dispersão dos votos. Segundo a perspectiva contextual, as pessoas votam nos candidatos a cujas mensagens políticas têm acesso e que correspondem às demandas dos lugares onde vivem. A partir da construção de um banco de dados sobre as eleições legislativas de 2010 a 2018, buscamos interpretar os resultados encontrados utilizando essa perspectiva. Partindo da hipótese de uma votação regida pela forma como as informações são difundidas no espaço, encontramos que a maioria dos candidatos tem sua maior votação no seu domicílio eleitoral declarado, que os com apenas experiência municipal apresentam um padrão de votação condizente com o efeito de “amigos e vizinhos” e que existe uma coordenação partidária na formação das listas. voto pessoal localizados votos contextual vivem 201 2018 espaço declarado amigos vizinhos listas 20 2

Résumé Alors que les premières études sur les stratégies électorales soutiennent que le système adopté au Brésil encourage le “vote personnel” et la création de bastions électoraux géographiquement localisés, des études plus récentes montrent que la stratégie électorale la plus efficace est la dispersion des votes. Selon la perspective contextuelle, les électeurs votent pour les candidats dont ils ont accès aux messages politiques et qui correspondent aux demandes des lieux où ils vivent. En construisant une base de données sur les élections législatives de 2010 à 2018, nous cherchons à interpréter les résultats trouvés en utilisant cette perspective. Partant de l’hypothèse d’un vote régi par la manière dont les informations sont diffusées dans l’espace, nous constatons que la plupart des candidats obtiennent leur plus grand nombre de votes dans leur domicile électoral déclaré, que ceux ayant seulement une expérience municipale présentent un schéma de vote cohérent avec l’effet “amis et voisins” et qu’il existe une coordination partisane dans la formation des listes. personnel localisés contextuelle vivent 201 2018 lhypothèse l hypothèse dun d lespace, lespace espace, espace l’espace déclaré leffet effet amis voisins quil qu il listes 20 2

Abstract While early studies on electoral strategies argue that Brazilian system encourages “personal vote” and the creation of geographically located electoral strongholds, latest studies show that the most effective electoral strategy is vote dispersion. According to the contextual perspective, people vote for candidates whose political messages they have access to and who correspond to the demands of the places where they live. Based on the construction of a database regarding the legislative elections from 2010 to 2018 we seek to interpret the results found using this perspective. Starting from the hypothesis of a vote ruled by the way information is diffused in space, we find that most candidates have their strongest vote in their municipality’s electoral domicile, that those with only municipal experience show a voting pattern consistent with the “friends and neighbors” effect, and that there is a party coordination in the formation of candidate lists.Keywords: localism; electoral concentration; electoral strategies; electoral behaviour; electoral geography. personal strongholds dispersion perspective live 201 space municipalitys municipality s domicile friends neighbors effect lists.Keywords listsKeywords lists Keywords localism concentration behaviour geography 20 2

Resumen Mientras que los primeros estudios sobre estrategias electorales sostenían que el sistema adoptado en Brasil fomenta el “voto personal” y la creación de bastiones electorales geográficamente localizados, estudios más recientes demuestran que la estrategia electoral más eficaz es la dispersión de los votos. Según la perspectiva contextual, las personas votan a candidatos a cuyos mensajes políticos tienen acceso y que corresponden a las exigencias de los lugares donde viven. A partir de la construcción de una base de datos sobre las elecciones legislativas de 2010 a 2018, tratamos de interpretar los resultados encontrados desde esta perspectiva. Partiendo de la hipótesis de que el voto se rige por la forma en que se difunde la información en el espacio, comprobamos que la mayoría de los candidatos obtienen el mayor número de votos en su domicilio electoral declarado, que los que sólo tienen experiencia municipal muestran un patrón de voto coherente con el efecto “amigos y vecinos” y que existe una coordinación partidista en la formación de las listas. personal localizados contextual viven 201 2018 espacio declarado amigos vecinos listas 20 2

Resumo A política de colonização interna no Brasil pós-Independência foi continuamente acionada e transformada ao longo dos séculos XIX e XX a fim de controlar populações insubmissas e territórios. A partir da análise bibliográfica e documental de um conjunto de projetos e experiências de colonização foi possível reconstruir o quadro interpretativo desta política, dando ênfase ao período da ditadura empresarial-militar e ao seu sentido de transformação do campesinato em classe média rural. Buscou-se identificar os principais elementos que constituem esse estrato, suas características e expectativas com base no conjunto de valores, interesses e pressupostos do complexo tecno-empresarial-militar a partir da política de colonização em sua formação. As continuidades e reconfigurações desta política nos permitem afirmar que colonizar é o verbo oculto do tratamento dado à questão agrária nacional. pósIndependência pós Independência territórios empresarialmilitar empresarial militar rural Buscouse Buscou se estrato valores tecnoempresarialmilitar tecno formação nacional

Résumé La politique de colonisation interne au Brésil après l’Indépendance a été continuellement activée et transformée au cours des XIXe et XXe siècles afin de contrôler les populations insoumises et les territoires. À partir de l’analyse bibliographique et documentaire d’un ensemble de projets et d’expériences de colonisation, il a été possible de reconstruire le cadre interprétatif de cette politique, en mettant l’accent sur la période de la dictature entreprise-militaire et sur son sens de transformation des paysans en classe moyenne rurale. Nous avons cherché à identifier les principaux éléments constitutifs de cette couche sociale, ses caractéristiques et ses attentes en fonction de l’ensemble des valeurs, intérêts et présupposés du complexe techno-entreprise-militaire à partir de la politique de colonisation dans sa formation. Les continuités et reconfigurations de cette politique nous permettent d’affirmer que coloniser est le verbe caché dans le traitement de la question agraire nationale. lIndépendance l Indépendance territoires lanalyse analyse dun d un dexpériences expériences laccent accent entreprisemilitaire entreprise militaire rurale sociale lensemble valeurs technoentreprisemilitaire techno formation daffirmer affirmer nationale

Abstract The internal colonization policy in post-Independence Brazil was continuously activated and transformed throughout the 19th and 20th centuries in order to control unsubmissive populations and territories. From the bibliographic and documentary analysis of a set of colonization projects and experiences, it was possible to reconstruct the interpretative framework of this policy, emphasizing the period of the corporate-military dictatorship and its meaning of transformation of the traditional peasantry into the rural middle class. We sought to identify the main elements that constitute this stratum, its characteristics and expectations based on the set of values, interests and assumptions of the techno-corporate-military complex, highlighting the role of the colonization policy in its formation. The continuities and reconfigurations of this policy allow us to state that talking about colonizing while it is the hidden verb of the treatment given to the national agrarian question. postIndependence post Independence th territories experiences corporatemilitary corporate military class stratum values technocorporatemilitary techno complex formation question

Resumen La política de colonización interna en el Brasil posterior a la independencia se activó y transformó continuamente a lo largo de los siglos XIX y XX con el fin de controlar a las poblaciones y territorios insumisos. A partir de un análisis bibliográfico y documental de una serie de proyectos y experiencias de colonización, fue posible reconstruir el marco interpretativo de esta política, haciendo hincapié en el periodo de la dictadura empresarial-militar y su transformación del campesinado en clase media rural. Se buscó identificar los principales elementos que componen este estrato, sus características y expectativas, con base en el conjunto de valores, intereses y supuestos del complejo tecno-empresarial-militar desde la política de colonización en su formación. Las continuidades y reconfiguraciones de esta política nos permiten afirmar que la colonización es el verbo oculto en el tratamiento de la cuestión agraria nacional. insumisos empresarialmilitar empresarial militar rural estrato expectativas valores tecnoempresarialmilitar tecno formación nacional

The first step in the synthesis of polyaniline doped with dodecylbenzene sulfonic acid is the synthesis of the anilinium dodecylbenzene sulfonate salt obtained through the reaction between aniline and dodecylbenzene sulfonic acid in aqueous medium. In this work, theoretical models were developed to simulate the formation mechanism of this salt in an aqueous medium. Changes in energy, frontier orbitals, gap energy, charge distribution and thermodynamic parameters were calculated. These theoretical results were correlated with the experimental data from the synthesis of the salt and from infrared spectroscopy. Theoretical models suggested that the solubilization of dodecylbenzene sulfonic acid and aniline in water are energetically and thermodynamically favorable processes. Interactions between the frontier orbitals indicated the formation of water-insoluble anilinium dodecylbenzene sulfonate salt. These molecular modeling results agree with experimental data indicating that the theoretical method used was efficient in simulating the reaction system. medium work energy calculated spectroscopy processes waterinsoluble insoluble system

The ability to argue is essential for the education of students, as it is fundamental to the presentation of ideas on a given topic. Several methods have been proposed in studies that support the development of argumentation in different teaching contexts, such as the heuristic diagram. It allows the organization and recording of activities that enable critical reflection through the analysis of the language used to express ideas. In this perspective, the diagrams produced for solving problems in an experimental chemistry subject offered in an undergraduate chemistry course were analyzed. Toulmin’s argument pattern was used as a basis to identify the structure of the arguments produced, and then, the quality of the arguments was evaluated. The results of the analysis showed a principle of progress in the argumentative capacity of undergraduates with the development of activities, verified by the presence of elements in students’ texts that, when present, validate an argument. Thus, the results can contribute to other researches in the field of chemical education by favoring a teaching process that considers the development of initial argumentative ability in the formation of students. students topic contexts diagram perspective analyzed Toulmins Toulmin s then evaluated present Thus

Nanoparticles of TiO2 doped with low amount of Fe were synthesized from natural ilmenite obtained from alluvial gold mine wastes. The obtained TiO2 were characterized using X-ray diffraction (XRD), X-ray fluorescence (XRF), Fourier-transform infrared spectroscopy (FTIR), UV-Vis diffuse reflectance, thermogravimetric analysis/differential scanning calorimetry (TGA/DSC), N2 adsorption-desorption isotherms, transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). The results confirm the formation of mesoporous TiO2 nanoparticles in anatase phase with 0.05 wt.% of iron possibly replacing some titanium places. All the characterizations were performed to the synthesized solid and the reference materials (TiO2 anatase and Degussa P25). The photocatalytic activity of both the synthesized solid and references were evaluated in the photo-oxidation of cyanide in aqueous medium under UV illumination. An experimental design type Box-Behnken was performed choosing three different parameters: the initial concentration of cyanide (50, 150 and 250 ppm) the catalyst load (0.1, 0.5 and 1.0 g L-1) and the oxygen source. The percentage of cyanide conversion was chosen as response in the design obtaining as optimal conditions [CN-]0 = 50 ppm, catalyst load = 0.6 g L-1 and air bubbling. Under these conditions it was reached 32, 32 and 89% of cyanide conversion for Fe-TiO2 synthesized, TiO2 anatase and Degussa P25, respectively. TiO wastes Xray X ray XRD, XRD , (XRD) XRF, XRF (XRF) Fouriertransform Fourier transform FTIR, FTIR (FTIR) UVVis Vis reflectance analysisdifferential analysis differential TGA/DSC, TGADSC TGA/DSC TGA DSC (TGA/DSC) N adsorptiondesorption adsorption desorption isotherms TEM (TEM XPS. XPS . (XPS) 005 0 05 0.0 wt wt. places (TiO P25. P25 P P25) photooxidation photo oxidation illumination BoxBehnken Box Behnken parameters 50, (50 15 25 ppm 0.1, 01 1 (0.1 5 0. 10 1. L1 L source CN0 CN [CN-] 06 6 L- bubbling 3 89 FeTiO2 FeTiO Fe-TiO respectively (XRD (XRF (FTIR (TGA/DSC (XPS 00 P2 (5 2 0.1 (0. [CN- 8 ( (0 [CN

The present work reports the in situ fabrication of Ag nanoparticles (AgNPs) in polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) over pre-patterned hydrophobic stripes on a hydrophilic glass surface. Microcontact printing (μCP) using octadecyltrichlorosilane (OTS) as “ink” was used to obtain these chemically modified substrates. A comparison of the results of the PS-b-P2VP self-assembly over a bare glass substrate and a pre-patterned glass substrate demonstrated the influence of the pattern on the film morphology. Polymeric films of Ag+ and PS-b-P2VP were prepared on a pre-patterned substrate and heated at 150 °C to enable the self-reconstruction of the polymeric matrix and the in situ formation of AgNPs (average particle size of approximately 100 nm). The AgNP/PS-b-P2VP thin films were characterized using UV-Vis spectroscopy and atomic force microscopy. The results demonstrate that the concentration of the solutions of Ag+/PS-b-P2VP used to prepare the films strongly influences the morphologies and dispersion of AgNPs. Moreover, the surface-enhanced Raman spectroscopy (SERS) activity of the fabricated polymer nanocomposites using Nile Blue as a molecular probe shows the importance of the chemical modification of the substrate in the enhancement of the SERS signal. (AgNPs polystyrenebpoly2vinylpyridine polystyrenebpolyvinylpyridine polystyrene b poly 2 vinylpyridine polystyrene-b-poly(2-vinylpyridine PSbP2VP PSbPVP PS P2VP P VP (PS-b-P2VP prepatterned pre patterned surface μCP (μCP OTS (OTS ink “ink substrates selfassembly self assembly morphology 15 C selfreconstruction reconstruction average 10 nm. nm . nm) AgNP/PSbP2VP AgNPPSbP2VP AgNPPSbPVP AgNP/PS AgNP UVVis UV Vis microscopy Ag+/PSbP2VP AgPSbP2VP AgPSbPVP Ag+/PS Moreover surfaceenhanced enhanced (SERS signal polystyrenebpoly PSbP PVP 1 AgNPPSbP AgNPPS AgPSbP AgPS

The Schröeder-van Laar equation to predict the theoretical eutectic melting temperature values was applied to a set of fourteen binary mixtures (UR1 to UR14). The fourteen binary mixtures belong to a structurally diverse group of organic molecules. They are represented by the 5-membered heterocycles containing N-S and N-O rings, flexible methylene chains (RH), semi-rigid semi-fluorinated chains (RF), and hydrogen bonds (HB). A virtual screening totalizing ninety-one possible theoretical combinations was planned. The UR1 to UR14 were prepared by mixing individual components using the calculated mole fractions. The experimental (Te) and theoretical (Tt) temperatures for the eutectic melting points were determined using polarized optical microscopy (POM) and differential scanning calorimetry (DSC) techniques. Heterogeneous mixtures were formed for components with large structural diversity as seen by POM. During the melting of the mixtures, irregular behavior through the segregation of the components was recorded. The study showed that the similarities in structural diversities favor the formation of homogeneous mixtures, with Te values approaching Tt, as predicted by the Schröeder-van Laar equation and by the theory of eutectic mixtures. Liquid crystal properties were affected in homogeneous binary mixtures containing one of the individual liquid crystal components. Schröedervan Schröeder van UR (UR UR14. . UR14) molecules 5membered membered 5 NS N S NO O rings RH, RH , (RH) semirigid semi rigid semifluorinated fluorinated RF, RF (RF) HB. HB (HB) ninetyone ninety planned fractions (Te Tt (Tt POM (POM DSC (DSC techniques recorded (RH (RF (HB

Parthenolide (PTN) is a secondary metabolite of the plant Tanacetum parthenium (L.) Schulz Bip. and is considered the chemical marker of this species. This sesquiterpene lactone (germacrene skeleton) has been described as responsible for the biological activity of the leaf extract. In addition, several studies in the literature have demonstrated its antiparasitic and antineoplastic activity. However, there is a need for knowledge of other safety parameters, such as pharmacokinetic, pharmacodynamic and toxicity evaluations. Therefore, in this investigation, the in vitro metabolism of parthenolide was performed with rat liver microsomes and biomimetic metabolism (such as cytochrome P-450 system) using organometallic catalysts. The biomimetic procedure was validated since the major compound of biomimetic oxidative reaction with meta-chloroperbenzoic acid catalyzed by metalloporphyrin 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin iron(III) chloride was also observed with rat liver microsomes. Previous chemoenzymatic synthesis studies of PTN afforded the same epoxide formation, this major oxidative compound was isolated and fully characterized as (1 R,10R)-epoxyparthenolide based on experimental and theoretical calculations of infrared (IR) and vibrational circular dichroism (VCD) data at the B3PW91/6-311G. Furthermore, for the first time, this metabolite was evaluated for trypanocidal and leishmanicidal activity. The mean inhibitory concentration (IC50) values were lower for PTN than its metabolite and showed significant cytotoxic effects for both parasites. This finding holds promise for addressing neglected diseases. (PTN L. L (L. Bip species germacrene skeleton extract addition However parameters pharmacokinetic evaluations Therefore investigation P450 P 450 P-45 system catalysts metachloroperbenzoic meta chloroperbenzoic 5,10,15,20tetrakispentafluorophenylporphyrin 5101520tetrakispentafluorophenylporphyrin tetrakispentafluorophenylporphyrin 5,10,15,20 tetrakis pentafluorophenyl porphyrin 5 10 15 20 ironIII iron III iron(III formation 1 ( R,10Repoxyparthenolide R10Repoxyparthenolide RRepoxyparthenolide R,10R epoxyparthenolide R 10R IR (IR VCD (VCD B3PW91/6311G. B3PW916311G BPWG B3PW91/6 311G. B3PW91 6 311G B PW G B3PW91/6-311G Furthermore time IC50 IC (IC50 parasites diseases (L P45 45 P-4 20tetrakispentafluorophenylporphyrin 5101520 5,10,15,2 2 10Repoxyparthenolide Repoxyparthenolide R10R RR 6311G B3PW91/6311G B3PW916 BPW B3PW91/ B3PW9 IC5 (IC5 P4 4 P- 510152 5,10,15, B3PW (IC 51015 5,10,15 5101 5,10,1 510 5,10, 51 5,10 5,1 5,

ABSTRACT Purpose: To determine the clinical outcomes in patients after type 1 Boston keratoprosthesis surgery and the significance of ultrasound biomicroscopy imaging for postoperative follow-up. Methods: This retrospective analysis included 20 eyes of 19 patients who underwent corneal transplantation with type 1 Boston keratoprosthesis between April 2014 and December 2021. Data on patient demographics, preoperative diagnosis, visual acuity, and postoperative clinical findings were analyzed. Results: Type 1 Boston keratoprosthesis implantation resulted in intermediate- and long-term positive outcomes. However, blindness and other serious complications such as glaucoma, retroprosthetic membrane formation, endophthalmitis, or retinal detachment also occurred. The use of ultrasound biomicroscopy imaging allowed for better evaluation of the back of the titanium plate, anterior segment structures, and the relationship of the prosthesis with surrounding tissues, which provided valuable postoperative information. Conclusion: Regular lifetime monitoring and treatment are necessary in patients who undergo Boston type 1 keratoprosthesis implantation for high-risk corneal transplantation. ultrasound biomicroscopy imaging can be a valuable imaging technique for the evaluation of patients with Boston type 1 keratoprosthesis, providing important information on anterior segment anatomy and potential complications. Further studies and consensus on postoperative follow-up protocols are required to optimize the management of patients with Boston type 1 keratoprosthesis. Purpose followup. followup follow up. up Methods 2 201 2021 demographics diagnosis acuity analyzed Results intermediate longterm long term However glaucoma formation endophthalmitis occurred plate structures tissues Conclusion highrisk high risk 202

To control vehicle emissions, the new homologation process must be reported according to the California Maximum Incremental Reactivity (MIR) scale’s procedure to calculate the ozone forming potential (OFP) of each new vehicle. This work calculates an MIR scale suitable for the Brazilian reality. Meteorological and hourly pollutant data from the Bangu Automatic Air Quality Station was inventoried and processed from March to September 2020 to adjust OZIPR Lagrangean model and obtain the MIR scale by making small increments in the concentrations of each volatile organic compounds (VOC) and calculate the ozone increase/decrease. It was found that the VOC that had the greatest impact on ozone formation was 1,2,4-trimethylbenzene, with 2.06 ppb O3 ppbC-1 VOC. The OFP was calculated based on the VOC emissions of a vehicle and it was found a value of 9.421 mg O3 km-1, a much lower value when compared using the California MIR scale of 136.608 mg O3 km-1. It is concluded that meteorological conditions and VOC speciation data in the air mixture in the studied region directly affect the photochemical reactions of ozone formation. (MIR scales s (OFP reality 202 (VOC increasedecrease increase decrease increase/decrease 1,2,4trimethylbenzene, 124trimethylbenzene trimethylbenzene 1,2,4 trimethylbenzene, 1 2 4 1,2,4-trimethylbenzene 206 06 2.0 O ppbC1 ppbC ppbC- 9421 9 421 9.42 km1, km1 km 1, km-1 136608 136 608 136.60 km1. 1. 20 4trimethylbenzene 1,2,4trimethylbenzene 124 1,2, 0 2. 942 42 9.4 km- 13660 13 60 136.6 12 1,2 94 9. 1366 6 136.

Resumo O Distrito Industrial de Marabá (DIM) é um local vinculado à transformação e ao beneficiamento de recursos sob uma ótica de agregação de valor ao minério de ferro de Carajás-PA. Porém, indústrias locais promoveram grande transformação espacial com o emprego de técnicas e tecnologias arcaicas e poluentes que, após aumento nos custos e alteração nos preços internacionais, tiveram as áreas abandonadas, indicando um processo de campo marrom (brownfield) em formação no DIM e áreas conexas. Seguiu-se um processo de transumância, acompanhado de ciclos de retração e concentração econômica. Verifica-se uma condição de periferia mineroindustrial na implantação e concepção do DIM, bem como a formação como um campo marrom, inclusive com repercussões espaciais, econômicas, demográficas e ambientais. (DIM CarajásPA. CarajásPA Carajás PA. PA Carajás-PA Porém que internacionais abandonadas brownfield (brownfield conexas Seguiuse Seguiu se transumância econômica Verificase Verifica espaciais econômicas ambientais

Abstract The Marabá Industrial District (MID) is a place connected with the transformation and processing of resources from the perspective of adding value to the iron ore of Carajás (State of Pará). However, local industries have promoted a great spatial transformation, using archaic and polluting techniques and technologies. After an increase in costs and changes in international prices, the areas of these industries were abandoned, indicating a brownfield process under formation in the MID and related areas. This was followed by a process of transhumance, accompanied by cycles of economic contraction and concentration. A mining-industrial periphery condition is perceived in the implementation and conception of the MID, as well as its formation as a brownfield, with spatial, economic, demographic, and environmental repercussions. (MID State Pará. Pará . Pará) However technologies prices abandoned transhumance concentration miningindustrial mining industrial demographic repercussions

With the increase in life expectancy and the significant incidence of lesions of the musculoskeletal system, both the public and private sectors seek improvements in their products and processes in order to contribute to the health of the population. Every year tons of chicken eggshell (CES) from domestic consumption are released in environment and the present work aims the production of a synthetic ceramic bone substitute using the eggshell as a source of calcium ions. According to the methodology, 5, 10, 15 and 20 mol% of iron ions were used and the characterization assays demonstrated the formation of a double calcium iron phosphate - Ca9Fe(PO4)7. MG63 cells were cultured on test specimens to cell viability assay and to each doped group analyzed, verifying cell compatibility with the studied compounds, as well as a good adhesion profile. Scanning electron microscopy (SEM) of the cells showed that material surface favored cell adhesion and the results demonstrated that the production of the compounds were viable to Ca9Fe(PO4)7 phase. So, in the future, it will be possible to have a final comprehensive biological compatibility of the prototype for further in vitro and in vivo assays. system population CES (CES methodology 5 10 1 2 mol Ca9FePO47. Ca9FePO47 CaFePO Ca9Fe PO4 7. 7 Ca Fe PO MG MG6 analyzed profile SEM (SEM Ca9Fe(PO4) phase So future FePO Ca9FePO4 CaFe Ca9Fe(PO4 Ca9FePO Ca9Fe(PO

Resumo Este artigo tem como objetivo descrever e analisar o processo de preservação e de refuncionalização do patrimônio industrial do Vale do Ruhr a partir de uma pesquisa de campo realizada na região entre outubro de 2023 e julho de 2024. Para tal finalidade, iniciaremos contextualizando o processo de industrialização e de desindustrialização ocorridos nos últimos 150 anos, no Vale do Ruhr, demonstrando suas conexões com a urbanização da área, bem como com a construção de uma identidade coletiva local fundamentada na memória do passado mineiro e industrial. Em seguida, demonstraremos como ocorreu o processo político e econômico que levou à formação da Rota do Patrimônio Industrial do Ruhr, um conjunto de espaços industriais de interesse histórico agora protegidos e reconvertidos a novas finalidades. 202 2024 finalidade 15 anos área seguida finalidades 20 1 2

Abstract This article aims to describe and analyze the process of preservation and repurposing of industrial heritage in the Ruhr Valley based on field research conducted in the region between October 2023 and July 2024. To achieve this, we will begin by contextualizing the industrialization and deindustrialization process that has been occurring over the last century and a half in the Ruhr Valley. We will demonstrate its connections with the urbanization of the area and the construction of a local collective identity grounded on the memory of the mining and industrial past. Then, we will explore the political and economic processes that led to the formation of the Ruhr Industrial Heritage Route, a collection of industrial sites of historical interest now protected and repurposed. 202 2024 this past Then Route repurposed 20 2