RESUMO Introdução Os profissionais de saúde estão expostos a um elevado número de fatores de risco psicossociais. Estes têm consequências a nível individual e organizacional. A psicologia da saúde ocupacional aplica princípios da psicologia na proteção e promoção da saúde e bem-estar dos trabalhadores. Neste âmbito, pode atuar a nível da organização, com intervenções que melhorem o ambiente de trabalho, e a nível individual, dotando os indivíduos de recursos para lidar com diferentes tipos de ambientes. Foi neste contexto que um serviço de saúde ocupacional de um centro hospitalar de Lisboa decidiu integrar na sua equipa um psicólogo. Objetivo Descrever uma amostra de profissionais de saúde referenciados à consulta de psicologia, com vista a gerar hipóteses quanto a características que possam constituir fatores de risco para carecer desse apoio. Metodologia Trata-se de um estudo descritivo em que a amostra corresponde ao grupo de trabalhadores referenciado à consulta de psicologia ao longo de sete meses. Foram avaliados os sintomas humor deprimido, pensamentos de morte, ansiedade e alterações do sono. Todos os dados provêm dos registos clínicos do psicólogo e do médico do trabalho, obtidos através de entrevista clínica, tendo sido previamente anonimizados. Resultados Foram acompanhados em consulta de psicologia 47 trabalhadores, correspondendo a 1% da população do centro hospitalar. O grupo profissional mais prevalente na amostra foram os assistentes operacionais. A maioria dos trabalhadores referia já ter um diagnóstico prévio de psicopatologia e 55% mantinham-se medicados. Apenas 15% dos trabalhadores identificavam o trabalho como fator determinante na sintomatologia. Discussão Verificou-se uma maior proporção do sexo feminino, em relação com a população global do centro hospitalar, um achado que poderá relacionar-se com um maior risco inerente às expectativas impostas pela sociedade relativamente ao papel da mulher como cuidadora e o acúmulo de funções na esfera social/familiar. Está ausente da amostra o grupo profissional “médicos”, hipoteticamente por uma menor afluência destes às consultas de medicina do trabalho ou eventual proteção conferida a níveis educacionais mais altos. Conclusões Ao contrário da evidência existente, nesta amostra de profissionais de saúde de um centro hospitalar de lisboa, o trabalho não foi o fator preponderante para o aparecimento de efeitos adversos na saúde e a determinar o seguimento em consulta de psicologia. No futuro, deve ser testada de forma mais robusta a relação entre género, nível educacional e grupo profissional e aumento do risco de psicopatologia.

ABSTRACT Introduction Healthcare workers are exposed to many psychosocial risk factors. These have consequences at an individual and organizational level. Occupational health psychology applies the principles of psychology to the protection and promotion of workers' health and well-being. Here, it can act at the organizational level, with interventions that improve the working environment, and at the individual level, providing individuals with resources to deal with different types of settings. It was in this context that the occupational health service of a Lisbon hospital center decided to incorporate a psychologist into its team. Objective To describe a sample of health professionals referred for a psychology consultation, looking to generate hypotheses about characteristics that may constitute risk factors for needing this support. Methodology This is a descriptive study in which the sample corresponds to the group of workers that was referred to psychology, over seven months. The following symptoms were assessed: depressed mood, thoughts of death, anxiety, and sleep disturbances. All the data came from the clinical records of the psychologist and the occupational medicine physician, obtained through a clinical interview, and were previously anonymized. Results A total of 47 workers were followed in psychology appointments, corresponding to 1% of the hospital's population. The most prevalent professional group in the sample was operational assistants. Most of the workers reported having a previous diagnosis of psychopathology and 55% were still medicated. Only 15% of the workers identified work as a determining factor in their symptoms. Discussion There was a higher proportion of women compared to the overall population of the hospital, a finding that could be related to a greater risk inherent in the expectations imposed by society regarding the role of women as caregivers and the accumulation of functions in the social/family sphere. The "doctors" professional group is absent from the sample, hypothetically due to their lower attendance at occupational medicine consultations or the possible protection afforded to higher levels of education. Conclusions Contrary to the existing evidence, in this sample of health professionals from a hospital center in Lisbon, work was not the preponderant factor for the appearance of adverse health effects and determining follow-up in psychology consultations. In the future, the relationship between gender, educational level and professional group and increased risk of psychopathology should be tested more robustly.

Resumo Objetos de aprendizagem (OA) são definidos como aqueles arquivos ou unidades digitais que podem ser utilizados em diferentes cenários e contextos pedagógicos. O objetivo deste trabalho foi caracterizar a utilização de vídeos polimídia (VP) como OA de conteúdos práticos de Bioquímica pelos alunos da disciplina de Biologia Molecular e Celular (BMC) da Faculdade de Medicina Veterinária. Para tanto, na seção específica do Ambiente Virtual de Aprendizagem de Bioquímica (EVA-FVet) dentro do curso BMC, foram oferecidos 10 VP de conteúdo prático para serem consultados como material de apoio antes de sua entrega e para elaboração de instâncias avaliativas e realização de exames. Usando estatísticas obtidas do YouTube, foram analisados para cada VP: número de visualizações, duração total das visualizações, tempo médio de reprodução, porcentagem média de reprodução, porcentagem do total de visualizações feitas por diferentes dispositivos (computador, celular e tablet). Os resultados obtidos mostraram que os VP foram visualizados em número semelhante ao número de alunos, reproduzidos em média com 63% de sua duração, havendo uma relação inversamente proporcional entre a duração e o percentual de reprodução. Foram visualizados através de computadores e, em menor escala, de telemóveis e tablets. Com este trabalho conclui-se que os alunos utilizaram o VP como OA para o acompanhamento das práticas, bem como para a elaboração de testes parciais e/ou exames.

Resumen Los objetos de aprendizaje (OA) se definen como aquellos archivos o unidades digitales que pueden ser utilizados en distintos escenarios y contextos pedagógicos. El objetivo de este trabajo fue caracterizar el uso de videos polimedia (VP) como OA de contenidos prácticos de Bioquímica por los estudiantes del curso de Biología Molecular y Celular (BMC) de la Facultad de Veterinaria. Para ello, en la sección específica del Entorno Virtual de Aprendizaje (EVA-FVet) de Bioquímica dentro del curso de BMC, se ofrecieron 10 VP de contenidos prácticos para ser consultados como material de apoyo antes del dictado de estos y para la preparación de instancias evaluativas y realización de exámenes. Mediante estadísticas obtenidas de YouTube, se analizó para cada VP: número de visualizaciones, duración total de las visualizaciones, tiempo medio de reproducción, porcentaje medio de reproducción, porcentaje de visualizaciones totales realizadas en distintos dispositivos (computadora, teléfono móvil y tablet). Los resultados obtenidos mostraron que los VP fueron visualizados un número de veces similar al número de estudiantes, reproducidos en promedio un 63 % de su duración, con una relación inversamente proporcional entre la duración y el porcentaje de reproducción. Además, fueron visualizados fundamentalmente en computadoras y, en menor medida, celulares y tablets. Con este trabajo se puede concluir que los estudiantes utilizaron los VP como OA para el seguimiento de los prácticos, así como para la preparación de pruebas parciales y/o exámenes.

Summary Learning objects (LO) are defined as those files or digital units that can be used in different scenarios and pedagogical contexts. The objective of this work was to characterize the use of polymedia videos (PV) as LO of practical biochemistry contents by the students of the Molecular and Cellular Biology (BMC) course of the Faculty of Veterinary Medicine. For this, in the specific section of the biochemistry Virtual Learning Environment (EVA-FVet) within the BMC course, 10 PV of practical content were offered to be consulted as support material prior to their delivery and for preparation of evaluative instances and carrying out exams. Using statistics obtained from YouTube, the following was analyzed for each PV: number of views, total duration of views, average playback time, average playback percentage, percentage of total views made by different devices (computer, mobile phone, and tablet). The results obtained showed that the VP were viewed in a number similar to the number of students, reproduced on average with 63% of their duration, with an inversely proportional relationship between the duration and the percentage of reproduction. In addition, they were fundamentally viewed through computers and, to a lesser extent, through cell phones and tablets. With this work it can be concluded that the students used the PV as LO for the follow-up of the practical ones, as well as for the preparation of partial tests and/or exams.

RESUMEN Introducción: el acceso a los servicios de salud en Paraguay, está determinado por varios tipos de barreras. Por ello, es preciso describir el impacto que tienen las políticas públicas y sus implicancias en la mitigación de las mismas. Objetivo: describir el acompañamiento diferenciado y su contribución al apoyo socio emocional, adhesión al tratamiento y acceso a servicios de salud en el área de atención a personas varones que viven con el VIH. Metodología: estudio de carácter cualitativo, descriptivo, con entrevistas semi estructuradas y muestra no probabilística, dirigida e intencional; Resultados: este estudio cualitativo exploró las experiencias de personas viviendo con VIH que recibieron acompañamiento psicosocial diferenciado en un servicio de atención integral. Los participantes destacaron la importancia del acompañamiento para afrontar la crisis posterior al diagnóstico. La orientación presencial, escucha empática y seguimiento facilitaron la vinculación y adherencia al servicio de salud y al tratamiento antirretroviral. El apoyo psicosocial fue clave para desmitificar ideas erróneas sobre el VIH/SIDA, empoderarse sobre su estado serológico y mejorar la calidad de vida. Se enfatizó el rol de los grupos de pares para brindar contención. Algunos participantes reportaron experiencias previas de revelación no consentida y vulneración de confidencialidad. El acompañamiento psicosocial diferenciado resultó fundamental para facilitar la inserción y permanencia de las personas con VIH en los servicios de atención integral (adhesión al tratamiento). Conclusiones: el acompañamiento psicosocial diferenciado resultó clave para facilitar la vinculación y adherencia en personas con VIH. La atención integral requiere identificar situaciones particulares, establecer relaciones de confianza y comunicación efectiva. El apoyo inicial es fundamental brindando contención ante el impacto emocional del diagnóstico. El seguimiento continuo es esencial dada la doble discriminación. La confidencialidad y capacidad de generar vínculos empáticos son elementos centrales. Los factores mencionados favorecen la adhesión al tratamiento. Los resultados sugieren que estas prácticas psicosociales pueden optimizar modelos de atención integral a personas con VIH.

ABSTRACT Introduction: access to healthcare services in Paraguay is influenced by various barriers. Thus, it is essential to describe the impact of public policies and their implications in mitigating these barriers. Objective: to describe the differentiated support and its contribution to socio-emotional support, therapeutic adherence, and access to healthcare services in the area of care for males living with HIV. Methodology: a qualitative, descriptive study with semi-structured interviews and a non-probabilistic, directed, and intentional sample. Results: this qualitative study explored the experiences of individuals living with HIV who received differentiated psychosocial support in an integrated care service. Participants emphasized the importance of support in coping with the post-diagnosis crisis. In-person guidance, empathetic listening, and follow-up facilitated engagement and adherence to healthcare services and antiretroviral treatment. Psychosocial support played a critical role in debunking misconceptions about HIV/AIDS, empowering individuals regarding their serostatus, and improving their quality of life. The role of peer groups in providing emotional support was emphasized. Some participants reported previous experiences of non-consensual disclosure and confidentiality breaches. Differentiated psychosocial support was essential in promoting the integration and retention of people with HIV in integrated care services (therapeutic adherence). Conclusions: differentiated psychosocial support was crucial in facilitating the engagement and adherence of individuals with HIV. Comprehensive care necessitates identifying specific situations, establishing trust-based relationships, and effective communication. Initial support is vital for providing emotional support in the face of the diagnostic impact. Ongoing follow-up is essential due to the dual discrimination faced. Confidentiality and the ability to build empathetic relationships are central elements. The aforementioned factors favor adherence to treatment. The results suggest that these psychosocial practices can enhance models of comprehensive care for people with HIV.

RESUMEN Introducción : El ondasentrón es un agente farmacológico de uso frecuente para el tratamiento sintomático de los vómitos originados por gastroenteritis. Sin embargo, podría enmascarar patologías más graves que ameriten reconsultas y hospitalización. Objetivo: Indagar si la administración del ondansetrón como tratamiento sintomático de los vómitos en el departamento de emergencias pediátricas (DEP) retrasó el diagnóstico de patologías graves. Materiales y métodos: Estudio observacional, descriptivo de corte transverso retrospectivo. Fueron elegibles pacientes que consultaron en el DEP, recibieron tratamiento con ondansetron, y reconsultaron dentro de las 24 horas. Los datos fueron recolectados de la base de datos de consultas del DEP, el comando reconsultas y entrevista telefónica a los padres. Las variables fueron edad, sexo, procedencia, motivo de la segunda consulta, diagnósticos finales en la segunda consulta. Los datos fueron analizados en SPSS utilizando estadística descriptiva. Resultados En el periodo de estudio consultaron por vómitos y recibieron ondasentrón 2018 pacientes. Reconsultaron dentro de las 24 horas 212, cumpliendo con los criterios de inclusión 205 pacientes. Se constató un 24,8% nuevos diagnósticos durante la reconsulta, de los cuales 35% requirieron hospitalización. Los diagnósticos fueron fiebre sin foco 2,9%, neumonía 2,4%, infección de vías urinarias 1%, sospecha de chikunguya 1,5%, adenitis mesentérica 0,5%, abdomen agudo quirúrgico 0,5%. Conclusión: Se identificó diagnósticos diferentes a la primera consulta en pacientes que recibieron ondansetrón como tratamiento sintomático de los vómitos en urgencias pediátricas, requiriendo hospitalización el 35% de los mismos.

ABSTRACT Introduction: Ondansetron is a pharmacological agent frequently used for the symptomatic treatment of vomiting caused by gastroenteritis. However, it could mask more serious pathologies that require repeat consultations and hospitalization. Objective: To investigate whether the administration of ondansetron as a symptomatic treatment of vomiting in the pediatric emergency department (PED) delayed the diagnosis of serious pathologies. Materials and methods: This was an observational, descriptive, retrospective and cross-sectional study. Patients who consulted at the PED, received treatment with ondansetron, and returned for consultation within 24 hours were eligible. Data were collected from the PED consultation database, the follow-up consultation request, and a telephone interview with parents. The variables were age, sex, origin, reason for the second consultation, and final diagnoses in the second consultation. The data were analyzed in SPSS using descriptive statistics. Results: During the study period, 2018 patients consulted for vomiting and received ondansetron. 212 were consulted again within 24 hours, with 205 patients meeting the inclusion criteria. There were 24.8% new diagnoses during the follow-up consultation, of which 35% required hospitalization. The diagnoses were fever without source 2.9%, pneumonia 2.4%, urinary tract infection 1%, suspected chikunguya 1.5%, mesenteric adenitis 0.5%, and surgical acute abdomen 0.5%. Conclusion: Diagnoses different from the first consultation were identified in patients who received ondansetron for symptomatic treatment of vomiting in pediatric emergencies, with 35% requiring hospitalization.

RESUMEN Introducción: La pandemia del COVID-19 alteró la vida de la población infantil. Según UNICEF, 1 de cada 7 niños se ha visto directamente afectado por los confinamientos en todo el mundo. Objetivo: Describir las características de la consulta y los diagnósticos de los pacientes que acudieron al departamento de salud mental del Hospital General Pediátrico Niños de Acosta Ñu, durante la pandemia COVID-19. Materiales y Métodos: Estudio observacional descriptivo transversal, retrospectivo. Se incluyeron a los pacientes que acudieron al Departamento de Salud Mental del Hospital General Pediátrico Niños de Acosta Ñu con diagnósticos psicopatológicos durante la pandemia COVID-19 en el periodo de marzo 2020 a marzo 2021. Las variables fueron: edad, sexo, procedencia, áreas de reclutamiento, tipo de consulta, modalidad de consulta, motivo de evaluación en salud mental, diagnóstico, tratamiento, hospitalización. Los datos se analizaron en IBM SPSS v.21 (demo) utilizando estadística descriptiva. El protocolo fue aprobado por el comité de ética. Resultados: Fueron incluidos 130 participantes, la mediana de edad fue de 13.5 años. El 81.5% procedían del Departamento Central y el 53.8% eran de sexo femenino. El 87.7% eran pacientes en seguimiento y el 69.2% realizaron la consulta de manera presencial. Los diagnósticos más frecuentes fueron, la depresión en un 51.5% y la negligencia o abandono en 27.7%. Se observó asociación de diagnósticos en 58.1%. El 70.8% requirió tratamiento y 10.8% requirió internación. Conclusión: Consultaron con mayor frecuencia adolescentes de sexo femenino. El diagnóstico más frecuente fue la depresión, acompañados de antecedentes de abuso sexual y/o de negligencia o abandono.

ABSTRACT Introduction: The COVID-19 pandemic altered the lives of the children's population. According to UNICEF, 1 in 7 children has been directly affected by lockdowns around the world. Objective: Describe the characteristics of the consultation and the diagnoses of the patients who attended the Mental Health Department of the Children General Pediatric Hospital “Acosta Ñu”, during the COVID-19 pandemic. Materials and methods: Observational, descriptive, cross-sectional, retrospective study that included those patients who attended the Mental Health Department of the Children Pediatric Hospital “Acosta Ñu” with psychopathological diagnoses during the COVID-19 pandemic in the period from March 2020 to March 2021. The variables were: age, sex, origin, recruitment areas, type of consultation, mode of consultation, reason for mental health evaluation, diagnosis, treatment, hospitalization. Data were analyzed in IBM SPSS v.21 (demo) using descriptive statistics. The protocol was approved by the ethics committee. Results: 130 participants were included with a median age of 13.5 years. 81.5% came from the Central Department and 53.8% were female. 87.7% were patients in follow-up and 69.2% had the consultation in person. The most frequent diagnoses were depression in 51.5% and neglect or abandonment in 27.7%. Association of diagnoses was observed in 58.1%. 70.8% required treatment and 10.8% required hospitalization. Conclusion: Female adolescents consulted more frequently. The most frequent diagnosis was depression, accompanied by a history of sexual abuse or neglect or abandonment.

RESUMEN Introducción: El cáncer de tiroides es una enfermedad frecuente en el mundo, con mayor prevalencia del tipo diferenciado. El diagnóstico temprano y manejo pertinente, individualizado y adaptable puede mejorar su pronóstico. Objetivo: Generar recomendaciones basadas en evidencia sobre el tratamiento y seguimiento de personas adultas con cáncer diferenciado de tiroides (CDT). Metodología: Guía de práctica clínica (GPC) a partir de revisión sistemática de literatura (RSL) y consenso de expertos clínicos. El grupo desarrollador definió el alcance y cuatro preguntas que se resolvieron a través de revisión de evidencia de GPC existentes, RSL, estudios primarios publicadas en español o inglés en diferentes fuentes de información desde 2013. Las preguntas de investigación fueron: 1. ¿Cuáles son las indicaciones de la vigilancia activa?, ¿cómo realizarla?, ¿cuándo y con que periodicidad realizarla? 2. ¿Cuál es el tratamiento y su indicación en pacientes con nódulos tiroideos sospechosos de cáncer? 3. ¿Cómo y cuándo realizar seguimiento de pacientes con CDT de acuerdo con el riesgo dinámico? 4. ¿Cuál es el manejo actual de los pacientes iodo refractarios? Se propusieron recomendaciones basadas en la evidencia, y analizadas y discutidas por el colectivo experto en sesiones asincrónicas. Se evalúo la calidad de la evidencia y las recomendaciones fueron gradadas en fuerte o condicional y a favor o en contra a partir del análisis de la calidad de la evidencia, contexto de implementación (disponibilidad e implementación) y la experticia clínica. En el presente documento se desarrollada la primera pregunta, referente a vigilancia activa. Resultados: 86 recomendaciones fueron propuestas y acordadas por el grupo desarrollador, categorizadas en tratamiento y seguimiento para resolver las preguntas planteadas. 10 de las recomendaciones corresponden a vigilancia activa y se incluyen en el presente documento. Recomendaciones claves incluyen, brindar información completa y oportuna a pacientes, conformación de equipos multidisciplinarios, análisis individualizado del paciente para la decisión de tratamiento, estadificación rutinaria de riesgo dinámico para evaluar la respuesta al tratamiento y ajustarlo, minimización de procedimientos fútiles o que aportan poco a la supervivencia y calidad de vida de los pacientes. Conclusión: Se presentan recomendaciones que esperan incidir en la estandarización de la práctica clínica cotidiana de pacientes con CDT y mejores resultados en salud.

ABSTRACT Introduction: Thyroid cancer is a common disease in the world, with a higher prevalence of the differentiated type. Early diagnosis individualized and adaptive management can improve prognosis. Objective: Generate evidence-based recommendations on the treatment and follow-up of adults with differentiated thyroid carcinoma (DTC). Methodology: Clinical practice guideline (CPG) based on systematic literature review (RSL) and consensus of clinical experts. The development group defined the range and four questions that were resolved through a review of evidence from existing CPGs, RSLs, primary studies published in Spanish or English in various sources of information since 2013. The research questions were: 1. What are the indications for active surveillance? How to carry it out? When and how often to carry it out? 2. What is the treatment and its indication in patients with thyroid nodules suspicious for cancer? 3. How and when to follow up patients with CDT according to dynamic risk? 4. What is the current management of iodine refractory patients? Evidence-based recommendations analyzed and discussed by the expert group in asynchronous sessions were proposed. The quality of the evidence was evaluated, and the recommendations were graded as strong or conditional and in favor or against based on the analysis of the quality of the evidence, implementation context (availability and implementation) and clinical expertise. In this document, is developed the first question, referring to active surveillance. Results: 86 recommendations were proposed and agreed upon by the development group, categorized into treatment and follow-up to solve the questions raised. 10 of the recommendations correspond to active surveillance and are included in this document. Key recommendations include providing complete and timely information to patients, develop of multidisciplinary teams, individualized patient analysis for treatment decisions, routine dynamic risk staging to evaluate response to treatment and adjust it, minimization of futile procedures or that contribute little to the survival and quality of life of patients. Conclusion: Recommendations are presented that longs to influence the standardization of the daily clinical practice of patients with DTC and better health outcomes.

RESUMEN Introducción: El virus chikungunya (CHIKV) causa una enfermedad con manifestaciones agudas bien documentadas, pero existen pocos datos sobre la persistencia de síntomas y secuelas a largo plazo. Objetivos: Evaluar la persistencia de signos, síntomas y factores asociados en pacientes con infección por CHIKV en un seguimiento de 6 meses posinfección. Materiales y métodos: Estudio de cohorte ambispectivo que incluyó casos confirmados de CHIKV notificados en abril de 2023 en Coronel Oviedo, Paraguay. Se realizaron entrevistas al mes, a los tres meses y a los 6 meses posinfección. Se analizaron características demográficas, comorbilidades, manifestaciones reumáticas y sintomáticas. Resultados: Ingresaron 333 participantes, completando seguimiento a 6 meses 170 pacientes. A los 6 meses persistieron: dolor de espalda (61.2%), artritis (57.1%), cefalea (54.1%), fatiga (51.2%), mialgia (49.4%), debilidad (47.6%), depresión (45.9%) y artralgia (45.9%). La persistencia de artritis (OR 7.54; p=0.008) y mialgia (OR 3.24; p=0.031) a 6 meses fue mayor en el grupo de 36-45 años. Conclusiones: Alta persistencia de síntomas musculoesqueléticos y fatiga hasta 6 meses posinfección, con tendencia decreciente, pero exacerbación de depresión. Edad entre 36-45 años asociada a mayor persistencia. Se requieren protocolos de seguimiento integral, investigar mecanismos fisiopatológicos y fortalecer prevención, dado el impacto individual y socioeconómico de la enfermedad.

ABSTRACT Introduction: Chikungunya virus (CHIKV) causes a disease with well-documented acute manifestations, but there is limited data on the persistence of symptoms and long-term sequelae. Objectives: To evaluate the persistence of signs, symptoms, and associated factors in patients with CHIKV infection during a 6-month post-infection follow-up. Material and Methods: An ambispective cohort study that included confirmed cases of CHIKV reported in April 2023 in Coronel Oviedo, Paraguay. Interviews were conducted at 1, 3 and 6 months post-infection. Demographic characteristics, comorbidities, rheumatic, and symptomatic manifestations were analyzed. Results: 333 participants were enrolled, with 170 patients completing the 6-month follow-up. At 6 months, the following symptoms persisted: back pain (61.2%), arthritis (57.1%), headache (54.1%), fatigue (51.2%), myalgia (49.4%), weakness (47.6%), depression (45.9%), and arthralgia (45.9%). The persistence of arthritis (OR 7.54, p=0.008) and myalgia (OR 3.24, p=0.031) at 6 months was higher in the 36-45 age group. Conclusions: High persistence of musculoskeletal symptoms and fatigue up to 6 months post-infection, with a decreasing trend but exacerbation of depression. Age between 36-45 years was associated with greater persistence. Comprehensive follow-up protocols, investigation of pathophysiological mechanisms, and strengthening prevention are required, given the individual and socioeconomic impact of the disease.

RESUMEN La mastitis linfocítica o mastitis diabética es una patología benigna rara, caracterizada por una inflamación fibrótica de la mama, causando gran preocupación por la simulación de un carcinoma. Está asociada por lo general a la diabetes tipo 2, aunque pueden presentarse en otras patologías autoinmunes y además en pacientes sin comorbilidades. Se presenta en caso clínico de una paciente joven sin comorbilidades que consulto en consultorio de patología mamaria por tumor mamario. Se realizó una biopsia percutánea por trucut con confirmación histológica de mastitis linfocítica, se realizó control cercano observándose remisión clínica e imagenológica de la lesión en 6 meses de seguimiento. Se presenta el caso a fin de recalcar la importancia del diagnóstico histológico percutáneo de la lesión para determinar la naturaliza de la misma, constatándose una patología benigna que no requiere resección, evitando así causar deformidades que podrían afectar psicológicamente a la paciente.

ABSTRACT Lymphocytic mastitis or diabetic mastitis is a rare benign pathology, characterized by fibrotic inflammation of the breast, causing great concern due to the simulation of carcinoma. It is generally associated with type 2 diabetes, although it can occur in other autoimmune pathologies and also in patients without comorbidities. The clinical case of a young patient without comorbidities who consulted in the breast pathology clinic due to a breast tumor. A percutaneous trucut biopsy was performed with histological confirmation of lymphocytic mastitis, close control was performed, observing clinical and imaging remission of the lesion in 6 months of follow-up. The case is presented in order to emphasize the importance of percutaneous histological diagnosis of the lesion, to determine its nature, confirming a benign pathology that does not require resection, thus avoiding causing deformities that could psychologically affect the patient.

RESUMEN El objetivo del presente trabajo es analizar los relatos de cuatro docentes de inglés becarios del programa Enseña Inglés (Go Teacher) y capacitados en un país angloparlante. Este artículo describe las experiencias de los participantes durante y después del programa, así como el impacto que tuvo el mismo en su práctica docente una vez que retornaron al país. Para ello, se empleó un enfoque cualitativo a través de un diseño biográfico-narrativo para explorar las percepciones de los participantes. Se identificó que el programa influyó de manera positiva en la adquisición del idioma inglés, ya que los participantes alcanzaron el nivel requerido para enseñar en Ecuador. Del mismo modo, el programa contribuyó a la formación metodológica al brindar nuevas estrategias para la enseñanza de esta lengua. No obstante, debido a que las cohortes estaban compuestas por un alto número de becarios en la misma universidad, el uso del inglés como medio de comunicación para la interacción fue limitado. Además, se evidenció un escaso seguimiento a los becarios una vez insertados en sus instituciones durante el período de compensación, lo que resultó en una disponibilidad mínima de información respecto al impacto del programa en el sistema educativo ecuatoriano.

ABSTRACT The objective of this paper is to analyze the accounts of four English teachers who received scholarships from the Go Teacher program and were trained in an English-speaking country. This article describes the participants' experiences during and after the program, as well as the impact it had on their teaching practice once they returned to the country. A qualitative approach using a biographical-narrative design was used to explore the participants' perceptions. It was identified that the program had a positive influence on English language acquisition, as participants reached the level required to teach in Ecuador. Similarly, the program contributed to methodological training by providing new strategies for teaching English. However, because the cohorts were composed of a high number of scholarship recipients at the same university, the use of English as a means of communication for interaction was limited. In addition, there was little follow-up with the scholarship recipients once they had returned to their institutions during the compensation period, which resulted in minimal availability of information regarding the impact of the program on the Ecuadorian educational system.

Resumo A síndrome VEXAS (vacúolos, enzima E1, cromossoma X, autoinflamação, mutação somática) foi identificada em 2020 por Beck et al, ao analisar o genoma de 2560 doentes com diferentes tipos de manifestações autoinflamatórias. Fizemos uma revisão da literatura com o objetivo de divulgar a evidência científica existente e aumentar o grau de suspeição clínica da comunidade médica. Atualmente, estão identificadas várias mutações associadas a esta síndrome, originando defeitos na ubiquitinação e ativação do sistema imune inato. Da análise fenotípica dos portadores da mutação, foram encontradas características comuns: sexo masculino, idade superior a 50 anos, citopenias, febre e sintomas constitucionais, podendo estar envolvidos todos os órgãos e sistemas com manifestações e proporções variáveis. A natureza inflamatória e multissistémica desta doença representa uma dificuldade acrescida no seu diagnóstico e tratamento, cursando com elevada morbimortalidade. Atualmente, os tratamentos com maior eficácia demonstrada são corticoterapia, azacitidina, inibidores da JAK-1/2 e inibidores da interleucina-6, parecendo também existir benefício com o transplante autólogo de células estaminais. Tendo em conta a sua identificação recente e baixo número de doentes diagnosticados, a maioria dos estudos disponíveis apresentam limitações relacionadas com a metodologia e curta duração de seguimento, imperando a necessidade de ensaios clínicos prospetivos de modo a definir as melhores estratégias terapêuticas e melhorar o prognóstico destes doentes.

Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome was identified in 2020 by Beck et al, when analyzing the genome of 2560 patients with different types of autoinflammatory manifestations. A literature review was carried out with the aim of disseminating existing scientific evidence and increasing the degree of clinical suspicion of the medical community. Currently, many mutations associated with this syndro-me have been identified, causing defects in the ubiquitylation and activation of the innate immune system. From the phenotypic analyses of the mutation carriers, some common features were found: male, over 50 years old, cytopenias, fever and constitutional symptoms, and all organs and systems with variable manifestations and proportions may be involved. The inflammatory and multi-systemic nature of this disease leads to a diagnostic and treatment challenge, adding to the already existing high morbimortality. Presently, the treatments with greater efficiency are corticosteroid therapy, azacytidine, JAK-1/2 inhibitors and interleukin-6 inhibitors. There are also benefits in autologous stem cell transplants. Given its recent identification and low number of diagnosed patients, most available studies have limitations related to the methodology and short duration of follow-up, prevailing the need for prospective clinical trials in order to define the best therapeutic strategies and to improve these patients’ prognosis.

Abstract Contrast-enhanced digital mammography (CEDM) is an emerging tool that has been increasingly implemented. It appears as an alternative to magnetic resonance imaging (MRI), using intravenous contrast to explore tumor angiogenesis. It combines conventional mammography (Mx) with post-contrast dual energy subtraction technique, resulting in increased detection of breast cancer, in a short study time and at a low cost. It is a promising method in selected cases and easy to read, being useful mainly in patients with breast cancer to detect additional lesions and determine the tumor size, that helps surgical planning, as well as in the evaluation of post-neoadjuvant chemotherapy response in the follow-up of patients treated with surgery, to address inconclusive findings in screening mammogram, or as an alternative when MRI is contraindicated. The purpose of this article is to assess the usefulness of contrasted mammography in daily practice and to determine its main indications. We review with our own cases the applications and characteristics of this method.

Resumen La mamografía contrastada (CEDM, contrast-enhanced digital mammography) es una herramienta nueva que ha ido implementándose de forma creciente. Aparece como alternativa a la resonancia magnética (RM), y al igual que esta, tiene como principio el uso de contraste endovenoso para explorar la angiogénesis tumoral. Combina la imagen de mamografía convencional (Mx) con la técnica de sustracción con energía dual poscontraste, lo que resulta en un incremento en la detección de cáncer de mama, en un tiempo corto de estudio y a un bajo costo. Es un método prometedor en casos seleccionados y de fácil lectura, siendo útil principalmente en pacientes con diagnóstico de cáncer de mama para detectar lesiones adicionales y determinar el tamaño tumoral, ayudando en la planificación quirúrgica, así como también en la evaluación de la respuesta a la neoadyuvancia. También en el seguimiento de pacientes operadas, para caracterizar lesiones dudosas en Mx y ecografía, o como alternativa ante contraindicación de la RM. El objetivo de este trabajo es valorar la utilidad de la mamografía contrastada en la práctica diaria y determinar sus principales indicaciones. Repasamos con casos propios las utilidades y características del método.

Abstract A persistent sciatic artery (PSA) is a rare anomaly and it is an embryologic remanent of the internal iliac artery, occurring in five different forms, depending on its relationship with the superficial femoral artery (SFA). Physicians must acknowledge the existence of this anomaly, and it should be included in the differential diagnosis of lower limb ischemia. We present the case of a 56-year-old female who presented with a popliteal artery acute ischemic event. Angiography showed a hypoplastic right SFA with a patent PSA vascularizing the lower extremity. A conventional embolectomy through a P1 popliteal incision was auspiciously performed. A magnetic resonance angiography confirmed a PSA of the right lower extremity during the post-operative period. At 12-month follow-up, the patient is well and asymptomatic.

Resumen Una arteria ciática persistente es una anomalía rara y un remanente embriológico de la arteria ilíaca interna. Se presenta en cinco formas diferentes, dependiendo de su relación con la arteria femoral superficial. Los médicos deben reconocer la existencia de esta anomalía y debe incluirse en el diagnóstico diferencial de isquemia de miembros inferiores. Presentamos el caso de una mujer de 56 años que consultó por un evento isquémico agudo de la arteria poplítea. La angiografía mostró una arteria femoral superficial derecha hipoplásica con una arteria ciática permeable persistente que vascularizaba la extremidad inferior. Se realizó auspiciosamente una embolectomía convencional a través de una incisión poplítea P1. Una angiografía por resonancia magnética confirmó una arteria ciática persistente de la extremidad inferior derecha durante el postoperatorio. A los 12 meses de seguimiento, la paciente se encuentra bien y asintomático.

BACKGROUND. Education about planetary health (PH) and sustainable healthcare (SH), or education for sustainable healthcare (ESH), enables health professionals to help protect public health and healthcare from climate change and environmental degradation. The Association for Medical Education in Europe Consensus (AMEE Consensus) Statement on Planetary Health and Education for Sustainable Healthcare has proposed a set of ESH learning objectives, activities and assessments for adaptation to different health professions education (HPE) contexts. The national audit phase of a mixed methods study in South Africa (SA) found that awareness of ESH and its curriculum development is emerging. The African Medical Education Directives for Specialists (AfriMEDS) is a competency framework for undergraduate medical students in SA that defines key competencies and enabling competencies related to seven roles of a health professional. OBJECTIVES. To recruit a national Delphi panel of health professions educators to assess the applicability of the AMEE Consensus learning objectives, activities and assessments to HPE in SA; to elicit panellists' perceptions of the main barriers and opportunities for ESH in faculties; and to compare learning objectives recommended by AMEE and the panel for key competencies and enabling competencies within the AfriMEDS framework. METHODS. Nine educators from three different disciplines and six national faculties of health sciences participated in two rounds of a Delphi process and in follow-up discussions. In round 1, they rated the AMEE Consensus learning objectives, activities and assessments, and proposed additional ones. In round 2, they rated the score-ranked AMEE lists, as well as relevant additions from round 1. All panellists participated in further discussions regarding applicability, and highlighted the potential barriers and opportunities for integrating ESH into their faculties. The lead author then matched the panel's learning objectives with enabling competencies related to all seven health professional roles described by AfriMEDS. RESULTS. All panellists recognised the importance of ESH in SA and the need for eco-ethical leadership by health professionals. All 13 AMEE Consensus learning objectives, as well as three additional objectives from the panel, were matched most frequently with AfriMEDS-enabling competencies related to the roles of leader and manager (n=9), communicator (n=8) and healthcare practitioner (n=7). Panellists highly ranked learning activities and assessments that are authentic, multiprofessional and require systems thinking. They perceived the lack of capable educators and curriculum overload to be the main barriers to integration of ESH, as well as the need for strong leaders, disciplinary champions and trained educators. CONCLUSIONS. Situating the selected learning objectives within the AfriMEDS competency framework provides a good basis for developing aligned learning activities and assessments of ESH. Strong leadership, capable educators and multidisciplinary collaboration are important enablers of integrating ESH into HPE in SA.

BACKGROUND. Registrars in specialisation training programmes encounter numerous difficulties in completing the research component of the Master of Medicine degree. Poor patient record-keeping hinders the research process. OBJECTIVES. To investigate current types of medical patient record-keeping systems (electronic v. paper) in training health facilities, and the effect data accessibility has on specialist training and research. METHODS. This was a mixed-methods study that included both descriptive and analytical components. Of 610 postgraduate students enrolled in the University of KwaZulu-Natal College of Health Sciences Master of Medicine programme, 168 completed a cross-sectional survey to collect data and 11 did follow-up interviews. The survey and interviews explored issues related to medical record-keeping in the participants' department or hospital, emphasising their experiences with data access while conducting research. The quantitative data were analysed using descriptive statistics, and the qualitative data were analysed thematically. Ethical approval was obtained from the institution's Biomedical Research Ethics Committee. RESULTS. Of the 168 participants, 94 (56%) reported that problems with data access hindered their research, while 56 (33%) indicated that data access did not affect their research. Only 30 participants (18%) had no difficulty in obtaining data for their research, while the rest (n=138; 82%) experienced varying degrees of difficulty. A total of 110 participants (65%) indicated that paper-based record-keeping was mainly being used in their department or hospital, while electronic record-keeping was reported by the rest (n=58; 35%). Many (n=125; 74%) expressed the need to improve hospital data management practices, and 39 (23%) reported that plans were being implemented to improve these practices. Participants expressed frustration with regard to accessing data even in departments that used electronic systems, and they raised concerns regarding data security. CONCLUSION. The migration to electronic patient record-keeping has not yet been implemented in many hospitals, with poor patient record-keeping affecting training and research.

Abstract Background: Neonatal lupus (NL) is extremely rare and is caused by the transplacental passage of maternal IgG autoantibodies against Ro, La, and/or RNP proteins into the fetal circulation, which can cause congenital complete atrioventricular block (CCAB), permanent skin lesions, and liver involvement. Objective: To know the prevalence of NL in patients with CCAB and the clinical course in long-term follow-up. Methods: From January 1992 to December 2017, patients with CCAB were included. The presence of anti-SSA/Ro and anti-SSB/La antinuclear antibodies in maternal serum confirmed NL. Results: Eight patients were included with a follow-up of 10 ± 6 years; NL was concluded in 62.5%; two were male. One of them was diagnosed in utero, two at birth, and a pacemaker was implanted in them, one at 12 years of age and another at 15. The other two cases were diagnosed at 18 and 26 years of age, and permanent pacemakers were implanted 8 and 5 years later, respectively. In one case, a definitive pacemaker was not implanted in a newborn with only 1 year of follow-up. At delivery, 60% of the mothers were free of rheumatic disease, and altogether, they all had 19 children; none of them presented NL manifestations. Conclusions: CCAB is rare and frequently associated with a maternal autoimmune disease, practically all of them will require a definitive pacemaker at some point in their lives.

Resumen Antecedentes: El lupus neonatal (LN) es extremadamente raro y es ocasionado por el paso transplacentario de auto-anticuerpos maternos IgG contra las proteínas Ro, La y/o RNP a la circulación fetal que puede ocasionar bloqueo aurículo-ventricular completo congénito (BAVCC) permanente, lesiones dérmicas y afectación hepática. Objetivo: Conocer la prevalencia de LN en paciente con BAVCC y la evolución clínica en un seguimiento a largo plazo. Métodos: De enero de 1992 a diciembre 2017 se incluyeron paciente con BAVCC. La presencia de anticuerpos antinucleares anti-SSA/Ro y anti-SSB/La en suero materno confirmó LN. Resultados: Ocho pacientes fueron incluidos con seguimiento de 10 ± 6 años, el 62.5 % con LN; dos fueron del sexo masculino. Uno diagnosticado in útero, dos al nacimiento, en ellos se implantó marcapaso; uno a los 12 años de edad y otro a los 15. Los otros dos casos fueron diagnosticados a los 18 y 26 años, se implantó marcapaso definitivo en ellos 8 y 5 años después respectivamente. En un caso no se implantó marcapaso definitivo; un recién nacido con solo un año de seguimiento. Al dar a luz, el 60 % de las madres estaban libres de enfermedad reumática y en conjunto todas tuvieron 19 hijos, ninguno de ellos presentó manifestaciones de LN. Conclusiones: El BAVCC es raro y frecuentemente está asociado a una enfermedad autoinmune materna, prácticamente todos requerirán de marcapaso definitivo en alguna época de su vida.