Species from Pavonia genus (Malvaceae) are traditionally used as antioxidant, n anti inflammatory and antimicrobial remedies. Previous studies have revealed their diversity of specialized metabolites widely used in the development of new medicines. This is the first study on Pavonia glazioviana Gurke, a Brazilian species known as “Malva da Chapada”. The research led to identify fifteen compounds: 132 (S) hydroxy pheophytin a; and 132(S) hydroxy 173 ethoxyphaeophorbide, n decanol, cycloart 23Z ene 3β,25 diol, cycloart 24S 25 ene 3β,24 diol, sitosterol 3 O β D glucopyranoside, stigmasterol 3 O β D glucopyranoside, quercetin, acacetin, kaempferol, tiliroside, 5 hydroxy 3,7,8,4’ tetramethoxyflavone, 5,7 dihydroxy 3,8,4’ trimethoxyflavone, 5,7 dihydroxy 4’ methoxyflavone, 5,7,4’ trihydroxy 3,8 dimethoxyflavone and 5,7,4’ trihydroxy 3 methoxyflavone. The major flavonoids were tested for their antimicrobial activity, and the compound 5,7 dihydroxy 3,8,4’ trimethoxyflavone showed strong activity against Escherichia coli (MIC = 512 μg mL1), Pseudomonas aeruginosa (MIC = 512 μg mL1), Candida albicans (MIC = 512 μg mL1), Candida tropicalis (MIC = 512 μg mL1), Candida parapsilosis (MIC = 512 μg mL1), Aspergillus flavus (MIC = 512 μg mL1) and A. fumigantus (MIC = 512 μg mL1). The total phenolic content, flavonoid content, and radical scavenging potential were determined showing its great production of phenolics and flavonoids, along with interesting radical scavenging potential (DPPH EC50 = 6.36 ± 0.029 mg mL 1). Our findings contributed to characterize P. glazioviana as a source of methoxylated flavonoids with antimicrobial potential. Malvaceae (Malvaceae antioxidant remedies medicines Gurke Malva Chapada. Chapada . Chapada” compounds 13 S (S 132S 132(S 17 ethoxyphaeophorbide decanol Z 3β25 3β 3β,2 diol 2 3β24 24 glucopyranoside quercetin acacetin kaempferol tiliroside 3,7,8,4 3784 7 8 4 tetramethoxyflavone 57 5, 3,8,4 384 methoxyflavone 5,7,4 574 38 3, MIC 51 mL1, mL1 , A mL1. content DPPH EC EC5 636 6 36 6.3 0029 0 029 0.02 1. 1 1) P 3β2 3β, 3,7,8, 378 3,8, 5,7, 63 6. 002 02 0.0 3,7,8 37 00 0. 3,7, 3,7

The exploration of carbon steel corrosion inhibition in 0.5 mol L-1 H2SO4 using extracts from Hymenaea courbaril (HC) has resulted in significant findings. Extracts from the bark, leaves, fruit pulp, and fruit shell have all proven to be effective corrosion inhibitors, as demonstrated through surface studies and electrochemical methods. Infrared spectroscopy and high-performance liquid chromatography have identified the presence of phenolic compounds, which are known to have corrosion-inhibiting potential. UV-Vis spectroscopy has further revealed the adsorption of extract species on the steel surface. Electrochemical studies have confirmed the inhibition of corrosion, allowing to propose mechanisms of both chemisorption and physisorption. X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS) have provided evidence of the formation of an inhibitory layer, further supporting the inhibition of corrosion. Langmuir isotherms have indicated favorable adsorption of the extracts, while reduced surface roughness suggests improved protection of the steel surface. Activation energy calculations have demonstrated an increase in energy barriers, resulting in slower corrosion rates. These findings suggest that extracts from Hymenaea courbaril show promise as eco-friendly corrosion inhibitors, with potential industrial applications. Further research is needed to optimize the extraction process and fully understand the inhibition mechanisms. 05 0 5 0. L1 L 1 L- HSO H SO H2SO HC (HC bark leaves pulp inhibitors methods highperformance high performance compounds corrosioninhibiting inhibiting UVVis UV Vis physisorption Xray X ray XPS (XPS energydispersive dispersive SEMEDS SEM EDS (SEM-EDS layer barriers rates ecofriendly eco friendly applications

This study evaluated the potential of naphthoxazoles derived from lapachol as fluorescent deoxyribonucleic acid (DNA) probes. We synthesized three 2-substituted naphthoxazoles: one with a phenyl group (LOX1), and two with 2-hydroxyphenyl (LOX2) and 4-fluorophenyl (LOX3) groups, respectively. The compounds were synthesized using the Debus-Radziszewski reaction between the lapachol and aldehydes. The quantum yield (Φf) was determined using the classical relative method with 4’,6-diamidino-2-phenylindole (DAPI) as the standard, and the fluorescence lifetime (τf) was measured with a lifetime fluorescence spectrometer. The naphthoxazoles exhibited low fluorescence emission and consequently low values of Φf in their free form, demonstrating behavior similar to that of DAPI. These compounds displayed notably large Stokes shifts (approximately 340 nm) and the τf in the nanosecond range. DNA binding studies were conducted by monitoring changes in the absorption properties of naphthoxazoles in the absence and presence of calf thymus DNA at different concentrations. The results indicated that naphthoxazoles interacted with DNA through groove binding. LOX2 exhibited a binding constant (Kb) of 2.70 × 104 M-1, indicating strong binding to the biomolecule. These findings underscore the potential of LOX1, LOX2, and LOX3 as candidates for use as fluorescent DNA probes. (DNA probes 2substituted substituted 2 LOX1 LOX , (LOX1) 2hydroxyphenyl hydroxyphenyl (LOX2 4fluorophenyl fluorophenyl 4 (LOX3 groups respectively DebusRadziszewski Debus Radziszewski aldehydes (Φf 4,6diamidino2phenylindole 46diamidino2phenylindole diamidinophenylindole ,6 diamidino phenylindole 6 DAPI (DAPI standard (τf spectrometer form approximately 34 nm range concentrations Kb (Kb 270 70 2.7 10 M1, M1 M 1, 1 M-1 biomolecule (LOX1 (LOX 6diamidino2phenylindole 3 27 7 2. M-

A growing body of literature suggests that the platformization of the public sphere is eroding the public debate, thus potentially leading to the fragmentation of the public sphere. While there exists mounting evidences supporting this perspective there also exists a substantial body of literature that suggests otherwise. Within this realm of mixed evidence, studies on climate change visibility play a prominent role, presenting findings that both weaken and reinforce the fragmentation hypothesis. To investigate this matter in a context conducive for a fragmented public sphere, we collected a longitudinal (2014-2022) and cross-platform (Instagram, Facebook and Twitter) dataset (n=794.281) and correlated it with a secondary database on the press coverage of climate change in Brazil (n=3.490). Our analysis reveals a robust positive correlation between these datasets, indicating that the Brazilian public sphere retains the capacity to interconnect various arenas of visibility. We argue that this finding is particularly significant, given that it emanates from a case characterized by circumstances favoring a high degree of public sphere fragmentation. Consequently, our discovery lends support to a less pessimistic assessment of the influence of platformization on political communication within the deliberative system. debate otherwise evidence role hypothesis 20142022 2014 2022 (2014-2022 crossplatform cross platform Instagram, Instagram (Instagram Twitter n=794.281 n794281 n 794 281 (n=794.281 n=3.490. n3490 n=3.490 . 3 490 (n=3.490) datasets significant Consequently system 2014202 201 202 (2014-202 n=794.28 n79428 79 28 (n=794.28 n349 n=3.49 49 (n=3.490 201420 20 (2014-20 n=794.2 n7942 7 2 (n=794.2 n34 n=3.4 4 (n=3.49 20142 (2014-2 n=794. n794 (n=794. n3 n=3. (n=3.4 (2014- n=794 n79 (n=794 n=3 (n=3. (2014 n=79 n7 (n=79 n= (n=3 (201 n=7 (n=7 (n= (20 (n (2 (

In this study, it was investigated chitosan (CHIT) films in the presence or absence of cellulose nanofibers (CNF) and silver nanoparticles (AgNP), whose chemical interactions involving metallic surfaces were characterized by surface-enhanced Raman scattering (SERS) spectroscopy. Changes in the morphology were analyzed through atomic force microscopy (AFM) and scanning electron microscopy (SEM). SEM and AFM micrographs revealed that the incorporation of CNF significantly altered CHIT films, leading to changes in the polymer topography and surface texture due to intimal interactions between CNF and the CHIT matrix. Raman spectra of CHIT and CNF/CHIT films showed similar profiles, reflecting comparable molecular structures of both modified biopolymers. However, SERS spectra of both films, after recovering with AgNP, demonstrated distinct spectral profiles. Innovatively, density functional theory (DFT) calculations of an oligomer model for CHIT were employed to assign the vibrational modes observed in the SERS spectra, which allowed identify key interactions between CHIT moieties and AgNP surfaces. SERS results revealed that chemical adsorption of CHIT on AgNP surfaces occurs through interactions of glycosidic oxygen and amino groups. Such findings provide insights into the structural and chemical behavior of this nanocomposite, highlighting its potential for advanced biological applications. study (CHIT (CNF , (AgNP) surfaceenhanced enhanced (SERS spectroscopy (AFM SEM. . (SEM) matrix CNFCHIT profiles biopolymers However Innovatively DFT (DFT groups nanocomposite applications (AgNP (SEM

This study offers a comprehensive analysis of how governance capacities in developing countries respond to the challenges that COVID-19 posed. We established a theoretical framework to delve into the multifaceted nature of governance capacities, exploring two distinct aspects of governance: the Weberian one, which focuses on material and organizational capacities, and the Tocquevillian one, which focuses on coordination and associational capacities. We examined these four governance dimensions to illustrate how these distinct skills influence the effectiveness of governance. Our analysis quantifies the impact of the COVID-19 pandemic using such metrics as confirmed cases and deaths. We employ standard and dynamic panel data methodologies to mitigate potential omitted variable bias. Our research findings indicate that countries with robust governance capacities, as assessed by the Bertelsmann Stiftung's Transformation Governance Index, are better equipped to respond effectively to pandemic crises. By applying several models and rigorous robustness tests, we demonstrate efficient resource utilization, the ability to guide and prioritize decision-making within the government, and commitment to cooperation and coordination with other nations and international organizations are the primary drivers of improved outcomes. Our findings remain robust even when controlling for relevant variables and employing estimation techniques that account for potential biases arising from unobservable confounding factors. COVID19 COVID 19 COVID-1 posed one deaths bias Stiftungs Stiftung s Index crises tests utilization decisionmaking decision making government outcomes factors COVID1 1 COVID-

RESUMO: Entender aspectos da germinação de sementes de espécies nativas do Cerrado pode auxiliar na escolha de espécies a serem utilizadas na restauração de ecossistemas degradados. Portanto, o estudo teve como objetivo verificar o efeito de cápsulas biodegradáveis na germinação de sementes de três espécies arbóreas típicas de fisionomias florestais do Cerrado (Enterolobium contortisiliquum, Anadenanthera colubrina e Dipteryx alata). O experimento foi conduzido em casa de vegetação, com dois tratamentos: semeadura no interior de cápsulas biodegradáveis e semeadura direta na superfície do substrato. Duas sementes de cada espécie foram utilizadas por tratamento, as quais foram acomodadas em sacos plásticos com substrato arenoso oriundo da classe Neossolo Quartzarênico. Para cada tratamento, foram utilizados cinco blocos (repetições), com 20 sacos plásticos cada. A casa de vegetação teve condições controladas de temperatura e umidade relativa. Dentro das cápsulas, os resultados mostraram que as sementes de baru, angico-branco e tamboril apresentaram germinação de 97%, 42% e 12%, respectivamente. Por outro lado, na semeadura direta, a germinação foi de 15% para baru, 21% para angico-branco e 8% para tamboril. Os resultados indicam que o uso de cápsulas biodegradáveis favorece a germinação das espécies do Cerrado estudadas. Assim, tanto a utilização das cápsulas quanto as espécies elencadas são recomendadas em projetos de restauração ecológica. RESUMO degradados Portanto Enterolobium contortisiliquum alata. alata . alata) tratamentos tratamento Quartzarênico repetições, repetições , (repetições) 2 relativa baru angicobranco angico branco 97 97% 42 12 12% respectivamente lado 15 21 8 estudadas Assim ecológica (repetições 9 4 1

ABSTRACT: A good grasp of the different facets of seed germination of the plant species native to the Cerrado will facilitate the selection of species that can be used to restore degraded ecosystems. Hence, the objective of the current study was to confirm the ways biodegradable capsules affect the germination of the seeds of three tree species typical of the physiognomies of the Cerrado forest (Enterolobium contortisiliquum, Anadenanthera colubrina and Dipteryx alata). The experiments, conducted in a greenhouse, included two treatments: seeding performed inside biodegradable capsules and direct seeding on the substrate surface. Two seeds from each of the species were sown in plastic bags containing the Quartzarenic Neosol class of substrates. Using five replicates for each treatment resulted in 20 plastic bags for each. The greenhouse conditions included controlled temperature and relative humidity. Inside the capsules, the findings revealed that the baru, angico-branco and tamboril seeds germinated at the rates of 97%, 42%, and 12%, respectively. However, during direct seeding, germination rates for baru, angico-branco and tamboril were 15%, 21% and 8%. From the findings, it is evident that when biodegradable capsules are used, the germination of all three Cerrado species investigated is favoured. Thus, both capsules and the cited species can be recommended for projects of ecological restoration. ABSTRACT ecosystems Hence Enterolobium contortisiliquum alata. alata . alata) experiments treatments surface substrates 2 humidity baru angicobranco angico branco 97 97% 42 42% 12 12% respectively However 15 15% 21 8 8% favoured Thus restoration 9 4 1

ABSTRACT Purpose: To compare the refractive prediction error of Hill-radial basis function 3.0 with those of 3 conventional formulas and 11 combination methods in eyes with short axial lengths. Methods: The refractive prediction error was calculated using 4 formulas (Hoffer Q, SRK-T, Haigis, and Hill-RBF) and 11 combination methods (average of two or more methods). The absolute error was determined, and the proportion of eyes within 0.25-diopter (D) increments of absolute error was analyzed. Furthermore, the intraclass correlation coefficients of each method were computed to evaluate the agreement between target refractive error and postoperative spherical equivalent. Results: This study included 87 eyes. Based on the refractive prediction error findings, Hoffer Q formula exhibited the highest myopic errors, followed by SRK-T, Hill-RBF, and Haigis. Among all the methods, the Haigis and Hill-RBF combination yielded a mean refractive prediction error closest to zero. The SRK-T and Hill-RBF combination showed the lowest mean absolute error, whereas the Hoffer Q, SRK-T, and Haigis combination had the lowest median absolute error. Hill-radial basis function exhibited the highest intraclass correlation coefficient, whereas SRK-T showed the lowest. Haigis and Hill-RBF, as well as the combination of both, demonstrated the lowest proportion of refractive surprises (absolute error >1.00 D). Among the individual formulas, Hill-RBF had the highest success rate (absolute error ≤0.50 D). Moreover, among all the methods, the SRK-T and Hill-RBF combination exhibited the highest success rate. Conclusions: Hill-radial basis function showed accuracy comparable to or surpassing that of conventional formulas in eyes with short axial lengths. The use and integration of various formulas in cataract surgery for eyes with short axial lengths may help reduce the incidence of refractive surprises. Purpose Hillradial Hill radial 30 0 3. 1 Methods SRKT, SRKT SRK T, T HillRBF RBF average methods. . methods) determined 0.25diopter 025diopter diopter 0.25 25 D (D analyzed Furthermore equivalent Results 8 findings errors HillRBF, RBF, zero coefficient both 100 00 >1.0 D. D) 050 50 ≤0.5 Moreover Conclusions 25diopter 025 0.2 2 10 >1. 05 5 ≤0. 02 0. >1 ≤0 > ≤

ABSTRACT Purpose: Although Brazil has a high prevalence of retinoblastoma, there is a lack of epidemiological data on the disease. Thus, in this study, we aimed to evaluate the epidemiological profile of patients diagnosed with retinoblastoma in the ophthalmology department of a pediatric tertiary referral hospital in Ceara, Brazil. Methods: A descriptive and cross-sectional study was conducted by retrospectively analyzing the clinical and socioeconomic data from the medical records of pediatric patients followed-up at the hospital between 2007 and 2021. Retinoblastoma was diagnosed on the basis of a fundoscopic or histopathologic examination. Results: The data of 105 patients were included in the study, and the mean patient age at the time of diagnosis was 1.7 years. Most of the patients were women (50.5%) and hailed from rural areas (57.4%), which was associated with a higher tumor stage. Of the 150 patients, 57.1% initially presented with leukocoria. Ocular hyperemia was associated with more advanced stages of retinoblastoma (p=0.004). Bilateral involvement was observed in 25.7% of the patients and at a significantly younger age (p=0.009). The presence of retinal detachment, vascularized lesions, and vitreous seeds significantly increased the likelihood of requiring enucleation. Discussion: This study presents an epidemiological description of retinoblastoma in Brazil, which highlights the significance of early detection. Delayed diagnosis is associated with a poorer visual prognosis and higher mortality rate, particularly in patients with unilateral disease. Risk factors for a more severe disease were retinal detachment, vascularized lesions, and vitreous seeds. The correlation between histopathological features and clinical outcomes was limited. Conclusion: Further studies are required to assess the influence of ocular hyperemia, fundoscopic assessment, and histopathologic findings on the prognosis of retinoblastoma. Moreover, it is critical to devise interventions to reduce the time-to-diagnosis in rural areas. Purpose Thus Ceara Methods crosssectional cross sectional followedup followed up 200 2021 examination Results 10 17 1 7 1. years 50.5% 505 50 5 (50.5% 57.4%, 574 57.4% , 57 4 (57.4%) stage 15 571 57.1 leukocoria p=0.004. p0004 p p=0.004 . 0 004 (p=0.004) 257 25 25.7 p=0.009. p0009 p=0.009 009 (p=0.009) detachment lesions enucleation Discussion detection rate limited Conclusion assessment Moreover timetodiagnosis 20 202 50.5 (50.5 57.4 (57.4% 57. p000 p=0.00 00 (p=0.004 2 25. (p=0.009 50. (50. (57.4 p00 p=0.0 (p=0.00 (50 (57. p0 p=0. (p=0.0 (5 (57 p=0 (p=0. ( p= (p=0 (p= (p

ABSTRACT Purpose: To evaluate the effect of upper eyelid ptosis repairwith Muller muscle-conjunctival resection on meibomian gland function and ocular surface parameters. Methods: Thirty-eight patients who underwent ptosis repair with Muller muscle-conjunctival resection were retrospectively reviewed. Meibomian gland loss, Ocular Surface Disease Index OXFORD score, meiboscore, and noninvasive keratograph break-up time were measured preoperatively and at 1st, 3rd, and 6th months postoperatively. Results: Noninvasive keratograph break-up time values decreased significantly at 1st and 3rd months postoperatively compared to the preoperative level, but were similar to the preoperative level at 6th months postoperatively (p<0.001 and p=0.628, respectively). Ocular surface disease index, OXFORD score, meibomian gland loss, and meiboscore values increased significantly in the 1st and 3rd postoperative months compared to the preoperative period, but these values decreased to preoperative levels in the 6th postoperative month (p<0.001 and p>0.05, respectively). Conclusion: There is a transient deterioration in meibography findings and OSDI score in the early postoperative period afterMuller muscle-conjunctival resection. Patients undergoing Muller muscle-conjunctival resection may require topical lubricants, especially in the first 3 postoperative months. Purpose muscleconjunctival muscle conjunctival parameters Methods Thirtyeight Thirty eight reviewed loss breakup break up st rd th Results p<0.001 p0001 p 0 001 (p<0.00 p0628 628 p=0.628 respectively. respectively . respectively) index p005 05 p>0.05 Conclusion lubricants p<0.00 p000 00 (p<0.0 p062 62 p=0.62 p00 p>0.0 p<0.0 (p<0. p06 6 p=0.6 p0 p>0. p<0. (p<0 p=0. p>0 p<0 (p< p=0 p> p< (p p=

RESUMO Objetivo: Avaliar a funcionalidade e fatores associados em crianças e adolescentes com osteogênese imperfeita (OI). Métodos: Estudo transversal com 30 crianças e adolescentes com OI. Foram avaliados prontuários médicos, uso de bisfosfonatos, características socioeconômicas, dinamometria de preensão palmar, equilíbrio, hipermobilidade articular, nível de deambulação e escores do Pediatric Evaluation of Disability Inventory - Computer Adaptative Test (PEDI-CAT). Os dados foram apresentados em média e desvio padrão e comparados por teste t por Mann-Whitney, enquanto os categóricos foram apresentados em frequência e comparados pelo teste exato de Fisher. Análises intragrupos foram realizadas por análise de covariância (ANCOVA) ou Teste de Wilcoxon para postos sinalizados. O teste Tau-b de Kendall foi usado para correlações. Resultados: A idade variou de 6 a 18 anos. A amostra foi dividida em dois grupos de acordo com a gravidade da doença. Casos moderados/graves (n=10) apresentaram menor estatura e força muscular comparadas às dos leves (n=20). Fraqueza muscular foi observada em todos os casos de OI quando comparados à população normal. Não houve diferença nos domínios do PEDI-CAT com exceção do domínio mobilidade. Houve correlação entre o número de fraturas, tipo de OI, peso e equilíbrio e o domínio mobilidade; e entre os domínios Atividades Diárias e Mobilidade e Responsabilidade e Social/cognitivo do PEDI-CAT. Conclusões: Nossos achados sugerem que crianças com OI moderada/severa podem atingir o mesmo nível de funcionalidade que crianças com a forma leve. Fraturas podem ter grande influência no nível de funcionalidade e o tratamento deve enfocar a prevenção e a reabilitação desses eventos. Objetivo . (OI) Métodos 3 médicos bisfosfonatos socioeconômicas palmar articular PEDICAT. PEDICAT PEDI CAT (PEDI-CAT) MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney Fisher ANCOVA (ANCOVA sinalizados Taub Tau b correlações Resultados 1 anos doença moderadosgraves moderados graves n=10 n10 n 10 (n=10 n=20. n20 n=20 20 (n=20) normal mobilidade fraturas Socialcognitivo Social cognitivo CAT. Conclusões moderadasevera moderada severa leve eventos (OI (PEDI-CAT n=1 n1 (n=1 n2 n=2 2 (n=20 n= (n= (n=2 (n

ABSTRACT Objective: The aim of this study was to evaluate the functioning and associated factors in children and adolescents with osteogenesis imperfecta (OI). Methods: This is a cross-sectional study conducted on 30 children and adolescents with OI. Medical records, use of bisphosphonates, socioeconomic status, handgrip strength, balance, joint hypermobility, ambulatory level, and the Pediatric Evaluation of Disability Inventory—Computer Adaptative Test (PEDI-CAT) scores were assessed. Data is presented as mean and standard deviation and Student’s t-test or Mann–Whitney U test. Categorical data is presented as frequency and analyzed using Fisher’s exact test. Within-group analyses were conducted using ANCOVA or Wilcoxon signed-rank test. Correlations used Kendall’s Tau-b test. Results: The participants involved in this study were 6–18 years old. The sample was separated into two groups according to disease severity. The moderate/severe OI group (n=10) presented a lower height and muscular strength than the mild group (n=20). Muscle weakness was observed in all participants with OI when compared with the normal population. No differences were observed between the groups in the PEDI-CAT scores except for the mobility domain. There were correlations between the PEDI-CAT mobility domain and the number of fractures, OI type, weight, and balance; there was also a correlation between the PEDI-CAT daily activities, mobility, responsibility, and social/cognitive domains. Conclusions: The findings suggest that children with moderate/severe forms of OI can achieve the same function levels as children with mild OI. Fractures can have a major influence on the functional level, and treatment should focus on the prevention and rehabilitation of these events when they occur. Objective . (OI) Methods crosssectional cross sectional 3 records bisphosphonates status balance hypermobility level InventoryComputer Inventory Computer PEDICAT PEDI CAT (PEDI-CAT assessed Students Student s ttest t test MannWhitney Mann Whitney Fishers Fisher Withingroup Within signedrank signed rank Kendalls Kendall Taub Tau b Results 618 6 18 6–1 old severity moderatesevere moderate severe n=10 n10 n 10 (n=10 n=20. n20 n=20 20 (n=20) population fractures type weight activities responsibility socialcognitive social cognitive domains Conclusions occur (OI 61 1 6– n=1 n1 (n=1 n2 n=2 2 (n=20 n= (n= (n=2 (n

RESUMO Objetivo: O objetivo deste estudo foi realizar a correlação genótipo-fenótipo entre os resultados de cariótipos e as alterações neurológicas e psiquiátricas apresentadas em pacientes com síndrome de Turner (ST). Métodos: Um estudo retrospectivo foi conduzido nos registros médicos de 10/140 pacientes com ST e deficiências neuropsicológicas atendidos pelo Serviço de Genética Clínica de um hospital do sul do Brasil. Ademais, uma revisão foi realizada pelas plataformas científicas PubMed e Biblioteca Virtual em Saúde (BVS) de artigos publicados entre 1o de janeiro de 2012 e 1o de janeiro de 2023. Foram selecionados 14 artigos em uma análise em duas etapas. Resultados: Nossa pesquisa mostrou potencial correlação entre alterações neurológicas e psiquiátricas em pacientes com ST. Esses achados corroboram os descritos por outros autores — como a elevada prevalência de dificuldades de aprendizagem ou intelectuais. Entretanto, nossa amostra encontrou mais episódios convulsivos do que os descritos em outros estudos. Conclusões: A correlação estabelecida pode ser devida ao efeito dose-dependente do cromossomo X, visto que nossa revisão sugere que o número de cromossomos sexuais ou o desenvolvimento hormonal está associado a habilidades ou deficiências verbais, sociais e cognitivas. Objetivo genótipofenótipo genótipo fenótipo . (ST) Métodos 10140 10 140 10/14 Brasil Ademais BVS (BVS 201 2023 1 etapas Resultados intelectuais Entretanto estudos Conclusões dosedependente dose dependente X verbais cognitivas (ST 1014 10/1 20 202 101 10/ 2

ABSTRACT Objective: The objective of this study was to establish the genotype-phenotype correlation between karyotype results and the neurological and psychiatric alterations presented in patients with Turner syndrome (TS). Methods: A retrospective study was conducted on the medical records of 10/140 patients with TS and neurophysiological abnormalities seen at a university hospital in southern Brazil. In addition, a literature review spanning the period from January 1, 2012 to January 1, 2023 was carried out using the PubMed and Virtual Health Library databases. Results: Our study showed a potential correlation between neurological and psychiatric alterations in patients with TS. These findings are in accordance with those described in literature such as a high prevalence of learning or intellectual disabilities. However, our sample found more seizure episodes than those reported in other studies. Conclusions: The correlation established could be due to X chromosome dose–effect, as the review suggests that sex chromosome number and hormonal development can be associated with verbal, social, and cognitive skills or impairments. Objective genotypephenotype genotype phenotype . (TS) Methods 10140 10 140 10/14 Brazil addition 1 201 202 databases Results disabilities However studies Conclusions doseeffect dose effect dose–effect verbal social impairments (TS 1014 14 10/1 20 101 10/ 2

The present study analyzed the chemical composition and phytotoxic activity of Artemisia lancea essential oil (EO). Gas chromatography-mass spectrometry (GC-MS) results showed the presence of 55 compounds, representing 82.36% of the entire EO, with eucalyptol (18.7%) being the most abundant constituent. Phytotoxic bioassay results indicated that the EO (concentration ranging from 0.25-5 mg mL−1) inhibited the growth of Amaranthus retroflexus and Setaria viridis. Root length of A. retroflexus and S. viridis were reduced with the increasing concentration of the EO, especially when the EO was applied at 1-5 mg mL−1. When treated with 1-5 mg mL−1 EO, shoot length of A. retroflexus and S. viridis were also significantly suppressed. The half maximal inhibitory concentration (IC50) values for inhibiting root and shoot growth of A. retroflexus by the EO were 0.284 and 0.246 mg mL−1; for S. viridis, the EO showed IC50 values of 0.44 and 0.262 mg mL−1 for root and shoot inhibition, respectively. The most promising findings were observed when A. lancea EO concentration reached 1 mg mL−1 and higher, which completely inhibited seed germination of A. retroflexus and S. viridis. These findings suggest A. lancea EO has potential as an eco-friendly bioherbicide for agricultural weed control. EO. . (EO) chromatographymass chromatography mass GCMS GC MS (GC-MS 5 compounds 8236 82 36 82.36 18.7% 187 18 7 (18.7% constituent 0.255 0255 0.25 0 25 0.25- mL1 mL A S 15 1- mL− suppressed IC (IC50 0284 284 0.28 0246 246 0.24 IC5 044 44 0.4 0262 262 0.26 inhibition respectively higher ecofriendly eco friendly control (EO 823 8 3 82.3 18.7 (18.7 255 025 0.2 2 (IC5 028 28 024 24 04 4 0. 026 26 82. 18. (18. 02 (IC (18 (1 (

Seaweeds have been explored by humans for thousands of years as a source of chemical compounds. This study describes the content of minerals, ash, carbohydrates, protein, lipids, and main metabolites of dichloromethane / methanol extracts of the seaweed Ulva lactuca, Padina gymnospora, Palisada perforata and Gelidiella acerosa from sandstone reefs on the Brazilian tropical coast (Pernambuco, Northeastern of Brazil). The content (% dry weight) of carbohydrates ranged from 14.35-48.52, proteins 7.49-14.98, total lipids 0.40-8.92, and ash 18.51-37.02. The concentration (mg kg dry algae−1) of Ca (900-3468), Mg (1655-4902), K (810-1707), Na (1062-4580), Mn (19-4462), and Cu (3.6-6.4) were maximum in Palisada and minimum in Padina. In turn, the lowest and highest contents (mg kg dry algae−1) of Fe (100-2312), Zn (18-43), and Cr (0.08-0.93) were recorded in Gelidiella and Ulva, respectively. Neophytadiene was the major compound. Phytol and palmitic acid were found in all seaweeds, although in low quantities. Palisada had the highest contents (% dry weight) of metabolites (neophytadiene: 23.89, phytol: 8.29; palmitic acid: 8.32), while Ulva had the lowest, except phytone, which was present only in this species. Our findings highlight the potential of these macroalgae from the coastal reefs as a source of chemical compounds. compounds minerals protein lactuca gymnospora Pernambuco, Pernambuco (Pernambuco Brazil. Brazil . Brazil) % ( weight 14.3548.52, 14354852 14.35 48.52, 14 35 48 52 14.35-48.52 7.4914.98, 7491498 7.49 14.98, 7 49 98 7.49-14.98 0.408.92, 040892 0.40 8.92, 0 40 8 92 0.40-8.92 18.5137.02. 18513702 18.51 37.02. 18 51 37 02 18.51-37.02 mg algae−1 algae1 algae 1 9003468, 9003468 900 3468 , (900-3468) 16554902, 16554902 1655 4902 (1655-4902) 8101707, 8101707 810 1707 (810-1707) 10624580, 10624580 1062 4580 (1062-4580) 194462, 194462 19 4462 (19-4462) 3.66.4 3664 3.6 6.4 3 6 4 (3.6-6.4 turn 1002312, 1002312 100 2312 (100-2312) 1843, 1843 43 (18-43) 0.080.93 008093 0.08 0.93 08 93 (0.08-0.93 respectively compound seaweeds quantities neophytadiene (neophytadiene 2389 23 89 23.89 phytol 8.29 829 29 8.32, 832 8.32 32 8.32) phytone species 3548 14.3548.52 1435485 1435 14.3 4852 48.52 5 14.35-48.5 4914 7.4914.98 749149 749 7.4 1498 14.98 9 7.49-14.9 408 0.408.92 04089 040 0.4 892 8.92 0.40-8.9 5137 18.5137.02 1851370 1851 18.5 3702 37.02 18.51-37.0 algae− 900346 90 346 (900-3468 1655490 165 490 (1655-4902 810170 81 170 (810-1707 1062458 106 458 (1062-4580 19446 446 (19-4462 66 3.66. 366 36 3. 64 6. (3.6-6. 100231 10 231 (100-2312 184 (18-43 080 0.080.9 00809 008 0.0 093 0.9 (0.08-0.9 238 2 23.8 8.2 82 83 8.3 354 14.3548.5 143548 143 14. 485 48.5 14.35-48. 491 7.4914.9 74914 74 7. 149 14.9 7.49-14. 0.408.9 0408 04 0. 8.9 0.40-8. 513 18.5137.0 185137 185 18. 370 37.0 18.51-37. 90034 34 (900-346 165549 16 (1655-490 81017 17 (810-170 106245 45 (1062-458 1944 44 (19-446 3.66 (3.6-6 10023 (100-231 (18-4 0.080. 0080 00 09 (0.08-0. 23. 8. 14.3548. 14354 48. 14.35-48 7.4914. 7491 7.49-14 0.408. 0.40-8 18.5137. 18513 37. 18.51-37 9003 (900-34 16554 (1655-49 8101 (810-17 10624 (1062-45 194 (19-44 (3.6- 1002 (100-23 (18- 0.080 (0.08-0 14.3548 14.35-4 7.4914 7.49-1 0.408 0.40- 18.5137 18.51-3 (900-3 (1655-4 (810-1 (1062-4 (19-4 (3.6 (100-2 (18 (0.08- 14.354 14.35- 7.491 7.49- 18.513 18.51- (900- (1655- (810- (1062- (19- (3. (100- (1 (0.08 (900 (1655 (810 (1062 (19 (3 (100 (0.0 (90 (165 (81 (106 (10 (0. (9 (16 (8 (0

Selenium-containing compounds exhibit diverse biological activities, such as antioxidative, anti-inflammatory, and cancer preventive effects. Using Caenorhabditis elegans as a model organism, we assessed the toxicity, neuroprotective, antioxidant properties, and impact on longevity of 11 selenoacetylenes. Their toxicity and bioactivities varied based on molecular structure. Selenoacetylenes with butyl substituents were toxic to Galleria mellonella larvae. The presence of but-3-in-2-ol radical increased antiprotozoal activity against Tetrahymena pyriformis. Compared to the positive control (Nimitz® EC), selenoacetylenes were less toxic to nematode worms and eggs. Selenoacetylenes significantly reduced amyloid beta (Aβ) paralysis in C. elegans CL4176 worms, increased longevity by 18 to 22%, along with improving survival after oxidative or thermal stress. Galantamine, showed inferior results. These findings enhance our understanding of selenoacetylenes on neuroprotection, antioxidant activity, and longevity in C. elegans. Future mammalian studies will further elucidate mechanisms and explore the potential therapeutic use of selenoacetylenes in treating Alzheimer’s disease and longevity. Seleniumcontaining Selenium containing activities antioxidative antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory effects organism neuroprotective properties 1 structure larvae but3in2ol butinol but 3 2 ol pyriformis Nimitz® Nimitz (Nimitz EC, EC , EC) eggs Aβ (Aβ C CL CL417 22 22% stress Galantamine results neuroprotection Alzheimers Alzheimer s CL41 CL4