Resumo A Avaliação Ambiental Estratégica (AAE) é aplicada em 90 países para integrar o meio ambiente ao planejamento, como planos diretores, mas permanece voluntária no Brasil. A dimensão ambiental em relatórios internacionais de AAE de planos diretores é discutida pelo referencial teórico de boas práticas de AAE para identificar contribuições para o contexto brasileiro. Verificou-se elevado número de evidências dessas boas práticas, de padronização de etapas, de integração entre os planejamentos urbano e ambiental corroborando características intrínsecas e sistêmicas da AAE que permitem integrar a dimensão ambiental em planos diretores, independente do contexto de planejamento do país. Recomenda-se que a AAE seja adotada localmente, pois possibilita fomentar a integração da temática ambiental em políticas intersetoriais urbanas, um desafio no planejamento urbano. (AAE 9 Brasil brasileiro Verificouse Verificou se etapas país Recomendase Recomenda localmente urbanas

Abstract The strategic environmental assessment (SEA) is applied in 90 countries to integrate the environment into planning, such as master plans, but remains voluntary in Brazil. The environmental dimension in international reports on SEA master plans is explored in this article using the theoretical framework of good SEA practices to identify contributions to the Brazilian context. Many of these practices were observed, such as standardization of stages and integration between urban and environmental planning, corroborating intrinsic and systemic SEA features that allow the integration of the environmental dimension into master plans regardless of the country’s planning context. We recommend that SEA be adopted locally to foster the integration of environmental issues into intersectoral urban policies, a challenge in urban planning. (SEA 9 Brazil context observed countrys country s policies

Two poly(acrylic acid-b-acrylamide) copolymers, and a poly(acrylic acid) homopolymer were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and tested for nickel removal from aqueous media. RAFT was used for better interchain composition homogeneity and to facilitate the synthesis of the block copolymers. Liquid-phase polymer-based retention (LPR) was used to compare the nickel binding capacity. Uptake tests were carried out at pH 3.0, 4.0, and 5.0. Nickel adsorption isotherms in the range of 1 to 7 mmol L−1 were achieved and the Langmuir adsorption model was applied. Maximum binding capacity (Qm) of Ni2+ at 298 K depended on the composition of the copolymers and pH. The polyacid block (PAA) was the major structural feature responsible for high values of nickel binding. All materials presented better uptake at higher pH, probably due to polyacid deprotonation and the increase in the electrostatic interactions. Up to approximately 100 mg of nickel per gram of homopolymer could be retained at pH = 5.0. Even though the presence of a poly(acrylamide) block decreases the binding capacity compared to PAA, that block has a specific contribution to nickel binding and can also provide better features to the material as better solubilization, and others. polyacrylic poly acrylic acidbacrylamide acid b acrylamide acid-b-acrylamide additionfragmentation addition fragmentation (RAFT media Liquidphase Liquid phase polymerbased polymer based LPR (LPR 30 3 0 3.0 40 4 4.0 50 5 5.0 L1 L L− applied Qm (Qm Ni2 Ni 29 PAA (PAA interactions 10 polyacrylamide poly(acrylamide solubilization others 3. 4. 5. 2

ABSTRACT The characterisation and evaluation of accessions are important steps in both the management of a germplasm collection and in a plant genetic improvement program. Carrying out characterisation and evaluation, whether morphological or molecular, requires observing the overall features of plants in the field, or collecting leaves for DNA extraction, which is time consuming and costly; whereas DNA extracted directly from the seeds allows access to the genome without the need for planting the seeds, which speeds up the selection of genotypes of interest and information on genetic variability. The aim was to develop a non-destructive method for extracting DNA from cashew seeds. The seeds were mechanically perforated using a mini-grinder, and a sample of the endosperm was removed. Various protocols and commercial kits for DNA extraction were tested, as well as materials to seal the opening made in the seed. It is possible to extract cashew tree DNA from the endosperm, preferably using commercial kits with cementitious adhesive as the sealing material, offering a germination percentage of 60% of the perforated seeds. program molecular field costly variability nondestructive non destructive minigrinder, minigrinder mini grinder, grinder mini-grinder removed tested seed material 60 6

This paper elucidates the inseparable connection between the pursuit of a more ecologically sustainable society and the quest for socioeconomic justice. It also demonstrates why Unconditional Basic Income (UBI) is an effective policy to act on both fronts. First, the corresponding theory on environmental and socioeconomic oppression sheds light on the argument that both types of domination stem from the same historical process and are inherently interconnected. Addressing one without considering the other is essentially flawed; they are both features and consequences of present society. Acknowledging the historical debt owed to vulnerable economic classes and developing countries is imperative. Green republicanism could potentially establish a theoretical foundation for social-ecological thinking. Defining freedom as non-domination and applying this concept to nature are essential prerequisites for overcoming socioeconomic and environmental oppression. UBI is presented and discussed theoretically as a strong solution to address these two challenges. It serves not only as a means to facilitate the transition to a post-productivist society, transforming labor relations, but also as a catalyst for the development of circular economies and more sustainable occupations. Additionally, the basic income policy implemented in the city of Maricá, Brazil, is cited as empirical evidence showcasing the environmental and socioeconomic values of UBI. justice (UBI fronts First interconnected flawed imperative socialecological social ecological thinking nondomination non challenges postproductivist post productivist relations occupations Additionally Maricá Brazil

In the present work, three series of cinnamic (1), p-coumaric (2) and ferulic (3) esters containing different side-chains such as ethyl (1a-3a), n-propyl (1b-3b), n-butyl (1c-3c), n-pentyl (1d-3d), n-hexyl (1e-3e), and n-heptyl (1f-3f) were prepared, tested for activity against trypomastigote forms of the parasite Trypanosoma cruzi and toxicity against NCTC cells. Obtained results indicated that the presence of p-coumaric or ferulic moieties associated with C4-C7 linear side-chains play an important role in the bioactivity against T. cruzi since compounds 2c-2f and 3d-3f were found to be the most active derivatives with a half maximal effective concentration (EC50) value ranging from 12.8 to 1.7 μM, superior to that determined for the positive control benznidazole (EC50 = 16.4 μM). Additionally, machine learning and multivariate statistical analyses identified molecular features correlated with biological activity, emphasizing the importance of side-chain length and lipophilicity, highlighting the significance of the molecular structure of phenylpropanoid derivatives in the activity against T. cruzi. work 1, 1 , (1) pcoumaric p coumaric 2 (2 3 (3 sidechains side chains 1a3a, 1a3a aa 1a 3a (1a-3a) npropyl n propyl 1b3b, 1b3b bb 1b 3b b (1b-3b) nbutyl butyl 1c3c, 1c3c cc 1c 3c c (1c-3c) npentyl pentyl 1d3d, 1d3d dd 1d 3d d (1d-3d) nhexyl hexyl 1e3e, 1e3e ee 1e 3e e (1e-3e) nheptyl heptyl 1f3f ff 1f 3f f (1f-3f prepared cells C4C7 CC C4 C7 C C4-C T 2c2f cf 2c 2f 3d3f df EC50 EC 128 12 8 12. 17 7 1. μM (EC5 164 16 4 16. μM. . μM) Additionally sidechain chain lipophilicity (1 ( (1a-3a (1b-3b (1c-3c (1d-3d (1e-3e C4C EC5 (EC

ABSTRACT Purpose: This study aimed to characterize retinitis pigmentosa associated with the eyes shut homolog gene, which causes hereditary retinal degeneration. Methods: The anatomical and functional findings of retinitis pigmentosa in patients with variants of the eyes shut homolog gene were characterized and compared using multimodal imaging and genetic analysis of the variants. Clinical data such as visual acuity, lens status, and refraction were obtained from medical records. Patients underwent an ophthalmic examination, including static visual field, microperimetry, optical coherence tomography, fundus autofluorescence, and fundus photography. Results: Twenty-two patients were included in the study. Several anatomical and functional characteristics of retinitis pigmentosa-eyes shut homolog were identified, including the presence of cataracts, cystoid macular edema, epiretinal membrane, and a tubular visual field. Genetic results revealed 26 distinct variants in the cohort, with 7 novel variants not previously documented or reported in the scientific literature or databases. Conclusion: The findings demonstrate that eyes shut homolog-retinitis pigmentosa manifests in specific patterns, starting in adolescence with mild progression and advancing with age. The integration of multimodal imaging and genetic analysis has provided a detailed understanding of the anatomical and functional features of retinitis pigmentosa-eyes shut homolog. Seven novel variants of the eyes shut homolog gene have been identified. These findings enhance the understanding of eyes shut homolog-related retinitis pigmentosa characteristics of by detailing the spectrum of mutations in this gene within the Brazilian population. Purpose degeneration Methods acuity status records examination field microperimetry tomography autofluorescence photography Results Twentytwo Twenty two pigmentosaeyes identified cataracts edema membrane 2 cohort databases Conclusion homologretinitis patterns age homologrelated related population

ABSTRACT Purpose: Although Brazil has a high prevalence of retinoblastoma, there is a lack of epidemiological data on the disease. Thus, in this study, we aimed to evaluate the epidemiological profile of patients diagnosed with retinoblastoma in the ophthalmology department of a pediatric tertiary referral hospital in Ceara, Brazil. Methods: A descriptive and cross-sectional study was conducted by retrospectively analyzing the clinical and socioeconomic data from the medical records of pediatric patients followed-up at the hospital between 2007 and 2021. Retinoblastoma was diagnosed on the basis of a fundoscopic or histopathologic examination. Results: The data of 105 patients were included in the study, and the mean patient age at the time of diagnosis was 1.7 years. Most of the patients were women (50.5%) and hailed from rural areas (57.4%), which was associated with a higher tumor stage. Of the 150 patients, 57.1% initially presented with leukocoria. Ocular hyperemia was associated with more advanced stages of retinoblastoma (p=0.004). Bilateral involvement was observed in 25.7% of the patients and at a significantly younger age (p=0.009). The presence of retinal detachment, vascularized lesions, and vitreous seeds significantly increased the likelihood of requiring enucleation. Discussion: This study presents an epidemiological description of retinoblastoma in Brazil, which highlights the significance of early detection. Delayed diagnosis is associated with a poorer visual prognosis and higher mortality rate, particularly in patients with unilateral disease. Risk factors for a more severe disease were retinal detachment, vascularized lesions, and vitreous seeds. The correlation between histopathological features and clinical outcomes was limited. Conclusion: Further studies are required to assess the influence of ocular hyperemia, fundoscopic assessment, and histopathologic findings on the prognosis of retinoblastoma. Moreover, it is critical to devise interventions to reduce the time-to-diagnosis in rural areas. Purpose Thus Ceara Methods crosssectional cross sectional followedup followed up 200 2021 examination Results 10 17 1 7 1. years 50.5% 505 50 5 (50.5% 57.4%, 574 57.4% , 57 4 (57.4%) stage 15 571 57.1 leukocoria p=0.004. p0004 p p=0.004 . 0 004 (p=0.004) 257 25 25.7 p=0.009. p0009 p=0.009 009 (p=0.009) detachment lesions enucleation Discussion detection rate limited Conclusion assessment Moreover timetodiagnosis 20 202 50.5 (50.5 57.4 (57.4% 57. p000 p=0.00 00 (p=0.004 2 25. (p=0.009 50. (50. (57.4 p00 p=0.0 (p=0.00 (50 (57. p0 p=0. (p=0.0 (5 (57 p=0 (p=0. ( p= (p=0 (p= (p

ABSTRACT: Meat consumption has been declining in favor of a shift towards poultry due to its lower price, health benefits and consumers’ preference. One of the ways to enhance broiler production and quality is to substitute standard maize (SM) with quality protein maize (QPM) in animal diets. QPM is a high lysine maize with improved nutritional and biological values, developed by the selection of a naturally occurring recessive opaque2 mutation, which can reduce the use of costly feed components - synthetic lysine and protein ingredients such as soybean and fishmeal. Different feeding trials with QPM in broiler diets indicated that body weight gain (BWG), feed conversion ratio (FCR), breast meat yield (BMY), and abdominal fat (AF) are the main improved features. Herein, an overview of the effects of QPM on broiler performance and carcass characteristics, as well as the financial effects of its use, is presented. Different effects of QPM were observed, depending, in the main, on the QPM hybrid used in the trial. The possible reasons for the discrepancies and suggestions for overcoming them, focused on the utilization of the full potential of QPM, are discussed. ABSTRACT price consumers preference SM (SM (QPM values opaque mutation fishmeal BWG, BWG , (BWG) FCR, FCR (FCR) BMY, BMY (BMY) AF (AF features Herein characteristics presented observed depending trial them discussed (BWG (FCR (BMY

Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the brain, and inhibiting this enzyme can reduce oxidative stress, stabilize neurotransmitter levels, and alleviate symptoms. In this context, a pharmacophoric model was created using PharmaGist with 31 hits extracted from BindingDB to enable a pharmacophoric-based search of potential MAO-B inhibitors in ZincPharmer’s chemical space, followed by the building of 10 conformers for each molecule in the software OMEGA, screening for structural and electrostatic similarity to safinamide using ROCS (Rapid overlay of chemical structures) and EON (Electrostatic similarity for lead-hopping), respectively. In addition, the molecular docking with Gold using the score function was performed to rank the ligands with the highest probabilities of affinity to MAO-B and then discriminate those with suitable physical chemical, pharmacokinetic, and toxicological features using the tools QikProp, SwissADME, and DEREK. Four potential ligands with selective MAO-B inhibitor properties were identified, which show promise as future therapeutic agents for MAO-B-related disorders. Worldwide schizophrenia depression diseases MAOB MAO (MAO-B brain stress levels symptoms context 3 pharmacophoricbased based ZincPharmers ZincPharmer s space 1 OMEGA Rapid structures Electrostatic leadhopping, leadhopping lead hopping , lead-hopping) respectively addition pharmacokinetic QikProp SwissADME DEREK identified MAOBrelated related disorders lead-hopping

A direct, high-throughput and accurate method, multi-molecular infrared spectroscopic (MMIR) data fusion, was established for the detection of trace of estrone, diethylstilbestrol, betamethasone and prednisone acetate in peptide powders based on near-infrared and mid-infrared fusion datasets. Tri step MMIR with progressively improved resolution captured key fingerprint features of hormones in the regions of 3430-3250, 2950-2850, 1750-1550 and 1335-1050 cm-1 which were exclusively selected as the datasets. The back propagation neural network (BPNN) model with the best performance used a mid-level fusion strategy and achieved excellent root mean square error of prediction (RMSEP, 1.101 mg kg-1) and residual prediction deviation (RPD, 9.890). Compared to those of single dataset models, the RMSEP was reduced by more than 82.03%. This method had remarkable practical significance for the direct and accurate quality evaluation of peptide powder products with favorable limit of detection (LOD) but without pretreatment and chemical agents, verifying the feasibility of multiple analytical instruments for rapid and comprehensive detection of powdered foods. highthroughput high throughput multimolecular multi molecular (MMIR estrone diethylstilbestrol nearinfrared near midinfrared mid datasets 34303250, 34303250 3430 3250, 3250 3430-3250 29502850, 29502850 2950 2850, 2850 2950-2850 17501550 1750 1550 1750-155 13351050 1335 1050 1335-105 cm1 cm 1 cm- BPNN (BPNN midlevel level RMSEP, (RMSEP 1101 101 1.10 kg1 kg kg-1 RPD, RPD (RPD 9.890. 9890 9.890 . 9 890 9.890) models 8203 82 03 82.03% LOD (LOD agents foods 3430325 343 325 3430-325 2950285 295 285 2950-285 1750155 175 155 1750-15 1335105 133 105 1335-10 110 10 1.1 kg- 989 9.89 89 820 8 0 82.03 343032 34 32 3430-32 295028 29 28 2950-28 175015 17 15 1750-1 133510 13 1335-1 11 1. 98 9.8 82.0 34303 3 3430-3 29502 2 2950-2 17501 1750- 13351 1335- 9. 82. 3430- 2950-

ABSTRACT: This essay analyzes the film Ratas, Ratones, Rateros (1999), by Ecuadorian director Sebastián Cordero, as a reflection of the social problems that affect contemporary Ecuador. Through a textual analysis of the work, it is examined how the main characters, two cousins who are dedicated to theft and crime, represent the Creole liveliness, social resentment and corruption that are some of the characteristic features of Ecuadorian society. Likewise, the film is contextualized with the political and economic scenario of the country at the end of the nineties, marked by the banking crisis, dollarization and government instability. The conclusion to be reached is that Ecuadorian cinema, more than a nationalist art, functions as a mirror of daily reality; as a reflection of the identity and social problems of Ecuadorians.

RESUMEN: En este trabajo se analiza la película Ratas, Ratones, Rateros (1999), del director ecuatoriano Sebastián Cordero, como un reflejo de las problemáticas sociales que afectan al Ecuador contemporáneo. A través de un análisis textual de la obra, se examina cómo los personajes principales, dos primos que se dedican al robo y la delincuencia, representan la viveza criolla, el resentimiento social y la corrupción, que son algunos de los rasgos característicos de la sociedad ecuatoriana. Asimismo, se contextualiza la película con el escenario político y económico del país a finales de los noventa, marcado por la crisis bancaria, la dolarización y la inestabilidad gubernamental. La conclusión a la se llegará es que el cine ecuatoriano, más que un arte nacionalista, funciona como un espejo de la realidad cotidiana; como un reflejo de la identidad y de los problemas sociales de los ecuatorianos.

Abstract This paper aims to explore one of the central chapters in Ulysses as a dramatic text, and, more importantly, its disruptive purport. Therefore, starting with the theoretical framework offered by the Drama Theory with its analytical tools, combined with a historical and a comparative perspective in order to place the text in the context in which it was generated and published and in relation to other texts and authorships, it explores some of its most relevant and renewing features. As the most important results, it is pointed out that the chapter that Joyce placed under the invocation of Circe is a profoundly innovative play, and it maintains parallels with the dramatic work of other transcendental authors in the 20th century.

Resumen Este artículo tiene como finalidad mostrar la condición de texto dramático de uno de los capítulos centrales en Ulysses, y sobre todo su voluntad rupturista. Para ello, a partir del marco teórico que ofrece la Teoría Dramática con sus herramientas analíticas, a las que se suman las perspectivas histórica o comparada para situar el texto en el contexto en que se genera y publica y en relación con otros textos o autorías, se consideran algunos de sus rasgos más relevantes y novedosos. Como resultados más notables se señala que el capítulo que en su día Joyce situó bajo la advocación de Circe, constituye una obra dramática profundamente innovadora y mantiene paralelismos con la obra dramática de otros autores transcendentales en el siglo XX.

Abstract: The use of e-commerce to enhance consumer relationships is becoming increasingly important in the information society. The constant development of technologies allows existing platforms to benefit from their characteristics; however, these advancements also bring various legal issues that must be addressed to protect users' interests and rights. Blockchain technology is revolutionizing B2C electronic relations due to its transnational nature, decentralization, guarantee of trust, immutability, and one of its most distinctive functionalities: smart contracts. These agreements are characterized by their automation and self-execution, features that can conflict with existing consumer and user legislation. Additionally, the opportunities provided by Blockchain, such as allowing users to act anonymously, may contradict regulations concerning the determination of international judicial jurisdiction and the applicable law for B2C consumer legal relationships. This work aims to analyze the applicability of smart contracts in e-commerce, particularly for B2C companies, and to study the potential issues they pose for current regulations, in order to determine whether these regulations need to be adapted for these technologies

Resumen: El uso del comercio electrónico para celebrar relaciones de consumo cada vez toma más protagonismo en la sociedad de la información. El constante desarrollo de las tecnologías hace que las plataformas existentes puedan beneficiarse de sus características; sin embargo, también traen consigo diferentes cuestiones jurídicas que deben mitigarse a fin de proteger los intereses y derechos de los usuarios. La tecnología blockchain es una de las tecnologías que viene a revolucionar el ámbito de las relaciones electrónicas B2C gracias a su carácter transnacional, descentralización, garantía de confianza, inmutabilidad y a una de sus funcionalidades más características: los smart contracts. Este tipo de acuerdos se distinguen por su automatización y autoejecución, caracteres que a priori pueden poner en riesgo la legislación existente sobre consumidores y usuarios. Asimismo, las oportunidades que brinda blockchain de cara a que los usuarios puedan actuar de forma irreconocible puede poner en jaque la normativa encargada de determinar la competencia judicial internacional y la ley aplicable a las relaciones jurídicas de consumo B2C. Este trabajo analiza la aplicabilidad de los smart contracts en el ámbito del comercio electrónico, en especial en el de empresas con consumidores (B2C) y estudiar los posibles inconvenientes que generan sobre la normativa existente a fin de analizar si es necesario adaptar la legislación a estas tecnologías

Resumo: A utilização do comércio eletrônico para efetivar relações de consumo assume cada vez mais um papel central na sociedade da informação. O constante desenvolvimento das tecnologias faz com que as plataformas existentes possam beneficiar-se das suas características, no entanto, também trazem consigo diversas questões jurídicas que devem ser mitigadas de forma a proteger os interesses e direitos dos usuários. A tecnologia blockchain é uma das tecnologias que veio revolucionar o campo das relações eletrônicas B2C graças ao seu carácter transnacional, descentralização, garantia de confiança, imutabilidade e uma das suas funcionalidades mais características, os smart contracts. Estes tipos de acordos distinguem-se pela sua automatização e auto-execução, características que, a priori, podem colocar em risco a legislação existente sobre consumidores e usuários. Da mesma forma, as oportunidades que o Blockchain oferece para que os usuários possam agir de forma irreconhecível podem colocar em xeque os regulamentos encarregados de determinar a competência judicial internacional e a lei aplicável às relações jurídicas de consumo B2C. O objetivo deste trabalho é analisar a aplicabilidade dos smart contracts no campo do comércio eletrônico, especialmente o de empresas com consumidores (B2C) e estudar os possíveis inconvenientes que eles geram sobre a regulamentação existente, a fim de analisar se é necessário adaptar a legislação a estas tecnologias

Resumen: La Enfermedad de Von Willebrand adquirida (EVW adquirida) es un trastorno hemorrágico adquirido poco frecuente, con características clínicas y de laboratorio similares a la Enfermedad de Von Willebrand congénita. Asociándose con enfermedades hemato-oncológicas, autoinmunes, cardiovasculares y tumores sólidos. Las gammapatías monoclonales constituyen un grupo heterogéneo de trastornos caracterizados por la proliferación de linfocitos B en los últimos estadios madurativos o células plasmáticas que preservan la capacidad de producir una inmunoglobulina (Ig) monoclonal o alguno de sus componentes. Como consecuencia, se produce la aparición de una paraproteína o componente M (CM) en suero y/o orina que estará formado por la misma cadena pesada o ligera, y por regiones variables idénticas. Se presenta el caso de una mujer de 57 años, que se presenta con un síndrome hemorragíparo, alteración de la crasis en su vía intrínseca, donde se diagnostica EVW adq secundaria a Mieloma Múltiple (MM) con CM IgM 5,9 g/dl. El tratamiento tuvo como objetivos detener el sangrado, prevenir complicaciones y abordar precozmente la patología hemato-oncológica causante. Para su abordaje requirió la realización de recambios plasmáticos terapéuticos (RPT) que tuvieron un rol de acción terapéutica temprana y eficaz con excelente tolerancia. Ante el diagnóstico se inició rápidamente poliquimioterapia siendo ésta una paciente candidata a trasplante de progenitores hematopoyéticos. El objetivo de la presentación de este caso clínico es destacar la importancia de un correcto y oportuno diagnóstico ante la sospecha clínica de una coagulopatía secundaria a una enfermedad hemato-oncológica subyacente. Por lo que hacemos énfasis en el abordaje multidisciplinario.

Resumo: A doença de von Willebrand adquirida (EVW acq, AVWS) é um distúrbio hemorrágico adquirido raro com características clínicas e laboratoriais semelhantes à doença de von Willebrand congênita. Associado a doenças hemato-oncológicas, autoimunes, cardiovasculares e tumores sólidos. As gamopatias monoclonais constituem um grupo heterogêneo de distúrbios caracterizados pela proliferação de linfócitos B nos últimos estágios de maturação ou plasmócitos que preservam a capacidade de produzir uma imunoglobulina monoclonal (Ig) ou um de seus componentes. Como consequência, ocorre o aparecimento de uma paraproteína ou componente M (CM) no soro e/ou na urina, que serão formados pela mesma cadeia pesada ou leve, e por regiões variáveis idênticas. Apresentamos o caso de uma mulher de 57 anos, que apresentava um síndroma hemorrágico, alteração da crase na sua via intrínseca, onde é diagnosticada Doença de Von Willebrand Adquirida secundária a Mieloma Múltiplo. O tratamento visava estancar o sangramento, prevenir complicações e abordar prontamente a patologia hemato-oncológica subjacente. Para sua abordagem, exigiu a realização de plasmaférese terapêutica que teve papel de ação terapêutica precoce e efetiva com excelente tolerância. Diante do diagnóstico, rapidamente foi iniciada poliquimioterapia, sendo este paciente candidato a transplante de células-tronco hematopoiéticas. O objetivo da apresentação deste caso clínico é realçar a importância de um diagnóstico correto e atempado face à suspeita clínica de uma coagulopatia secundária a uma doença hemato-oncológica subjacente. Portanto, enfatizamos a abordagem multidisciplinar.

Abstract: Acquired von Willebrand disease (AVWS) is a rare acquired bleeding disorder with clinical and laboratory features similar to congenital von Willebrand disease. Associated with hemato-oncological, autoimmune, cardiovascular diseases and solid tumors. Monoclonal gammopathies constitute a heterogeneous group of disorders characterized by the proliferation of B lymphocytes in the last stages of maturation or plasma cells that preserve the capacity to produce a monoclonal immunoglobulin (Ig) or one of its components. As a consequence, the appearance of a paraprotein or M component (CM) occurs in serum and/or urine, which will be formed by the same heavy or light chain, and by identical variable regions. We present the case of a 57-year-old woman, who presented with a hemorrhagic parous syndrome, alteration of the crasis in its intrinsic way, where Acquired Von Willebrand Disease secondary to Multiple Myeloma is diagnosed. Treatment was aimed at stopping the bleeding, preventing complications, and promptly addressing the underlying hemato-oncological pathology. For its approach, it required the performance of therapeutic plasma exchanges that had a role of early and effective therapeutic action with excellent tolerance. Given the diagnosis, polychemotherapy was quickly started, this patient being a candidate for hematopoietic stem cell transplantation. The objective of presenting this clinical case is to highlight the importance of a correct and timely diagnosis in the face of clinical suspicion of a coagulopathy secondary to an underlying hemato-oncological disease. Therefore, we emphasize the multidisciplinary approach.

RESUMEN Se valora críticamente las insuficiencias desde los fundamentos de la economía política reflejadas en la Conceptualización del modelo económico cubano en los documentos aprobados por el VIII Congreso del PCC. Se expone la necesidad de una institucionalidad socialista transparente y democrática que garantice la implementación de las decisiones económicas y pueda neutralizar las deformaciones burocráticas del aparato estatal en todos sus niveles. Se precisa la esencia de la propiedad social de todo el pueblo, sus dimensiones principales; así como el rol de la planificación a través de macroprogramas, programas y proyectos. Se determinan los rasgos principales del socialismo con mercado y se caracterizan las principales relaciones con el sector privado en condiciones de transición socialista.

ABSTRAC The insufficiencies from the foundations of Political Economy reflected in the Conceptualization of the Cuban economic model in the documents approved by the 8th Congress of the PCC are critically assessed. The need for a transparent and democratic socialist institutionality is exposed that guarantees the implementation of economic decisions and can neutralize the bureaucratic deformations of the state apparatus at all levels. The essence of the Social Property of the entire people is specified, its main dimensions; as well as the role of Planning through Macroprograms, Programs and Projects. The main features of Socialism with Market are determined and the main relationships with the private sector are characterized in conditions of socialist transition.