The development of gene expression profiling and next-generation sequencing technologies have steered oncogenomics to the forefront of precision medicine. This created a need for harmonious cooperation between clinicians and researchers to increase access to precision oncology, despite multiple implementation challenges being encountered. The aim is to apply personalised treatment strategies early in cancer management, targeting tumour subtypes and actionable gene variants within the individual's broader clinical risk profile and wellbeing. A knowledge-generating database linked to the South African Medical Research Council's Genomic Centre has been created for the application of personalised medicine, using an integrated service and research approach. Insights gained from patient experiences related to tumour heterogeneity, access to targeted therapies and incidental findings of pathogenic germline variants in tumour DNA, provided practice-changing evidence for the implementation of a cost-minimisation pathology-supported genetic testing strategy. Integrating clinical care with genomic research through data sharing advances personalised medicine and maximises precision oncology benefits.

ABSTRACT Introduction: Competences in primary healthcare should characterize the profile of health professionals working at that level. Objective: To describe the competences of health professionals for the implementation of primary healthcare. Methods: A qualitative-descriptive study, following Margarete Sandelowski’s postulates and the Ritchie and Spencer’s method, was carried out in Bogota and Soacha during the year 2021. Semistructured interviews were applied to 9 health professionals. Results: The competences that should characterize primary healthcare teams are linked to the elements, components and principles of primary healthcare itself, with emphasis on health promotion and disease prevention, as well as family and community orientation, intersectoral and interdisciplinary work, health education for self-care, training in health policy and comprehensive care. Conclusions: Practicing in primary healthcare requires specific competences for assistance and administrative management; it requires high scientific, ethical and humanistic knowledge, as well as soft skills: leadership, collaborative work, decision-making capacity and conflict resolution. It also requires financial resources and overcoming structural barriers that compromise the work of professionals in charge of guaranteeing compliance and effectiveness of primary healthcare in Colombia.

RESUMEN Introducción: Las competencias en atención primaria de salud deben caracterizar el perfil de los profesionales de la salud que se desempeñan en atención primaria. Objetivo: Describir las competencias del profesional de salud para la implementación de la atención primaria. Métodos: Estudio cualitativo descriptivo bajo los postulados de Margarete Sandelowski y el método de Ritchie y Spencer. Realizado en Bogotá y Soacha durante el año 2021. Se aplicaron entrevistas semiestructuradas a nueve profesionales de la salud. Resultados: Las competencias que deben caracterizar a los equipos de Atención Primaria están vinculadas con los elementos, componentes y principios de la atención primaria de salud, con énfasis en promoción de la salud y prevención de la enfermedad, la orientación familiar y comunitaria, el trabajo intersectorial e interdisciplinario, la educación en salud para el autocuidado, la formación en política en salud y la atención integral. Conclusiones: Desempeñarse en Atención Primaria requiere competencias específicas para la asistencia y la gestión administrativa; exige altos conocimientos científicos, éticos, humanísticos y competencias blandas: liderazgo, trabajo colaborativo, capacidad para la toma de decisiones y resolución de conflictos; recursos financieros y superar barreras estructurales que comprometen el trabajo de los profesionales encargados para garantizar el cumplimiento y la efectividad de la atención primaria en Colombia.

RESUMO Objetivo: identificar o perfil dos atendimentos às tentativas de suicídio por adolescentes em pronto-socorro e seus fatores associados. Método: estudo transversal, documental e retrospectivo, realizado com 140 prontuários de adolescentes atendidos por tentativa de suicídio em um departamento de urgência e emergência, vinculados a um hospital escola do município de São Paulo, Brasil, entre janeiro de 2015 e maio de 2023. Os dados foram coletados entre agosto e novembro de 2023. Foi realizada uma análise descritiva e inferencial (teste qui-quadrado de Pearson), considerando o valor de p≤0,05 como diferença estatística. Respeitaram-se as diretrizes éticas nacionais. Resultados: prevaleceram as intoxicações medicamentosas, associadas com o sexo feminino (p<0,001) e com o uso de medicações psicotrópicas contínuas (p=0,01). Nas intoxicações por veneno, observou-se associação com a ausência de uso de medicação psicotrópica contínua (p=0,02) e atendimento em sala de emergência (p=0,01). O sexo masculino se associou com intoxicações por álcool e outras drogas (p<0,001), ferimento por arma branca (p<0,05) e precipitação (p=0,03). Conclusão: neste estudo, observou-se uma prevalência de atendimentos às tentativas de suicídio por intermédio de intoxicações associadas com sexo, uso de medicação e atendimento em sala de emergência. Espera-se que, com este perfil, os profissionais possam estruturar planos de ação para aperfeiçoar o atendimento clínico, o acolhimento em saúde mental, e estratégias de prevenção e acolhimento pós-tentativa. Objetivo prontosocorro pronto socorro associados Método transversal retrospectivo 14 Paulo Brasil 201 2023 teste quiquadrado qui quadrado Pearson, Pearson , Pearson) p005 p 0 05 p≤0,0 estatística Respeitaramse Respeitaram nacionais Resultados medicamentosas p<0,001 p0001 001 (p<0,001 p=0,01. p001 p=0,01 . 01 (p=0,01) veneno observouse observou p=0,02 p002 02 (p=0,02 p<0,001, p<0,05 (p<0,05 p=0,03. p003 p=0,03 03 (p=0,03) Conclusão Esperase Espera que clínico mental póstentativa. póstentativa pós tentativa. pós-tentativa 1 20 202 p00 p≤0, p<0,00 p000 00 (p<0,00 p=0,0 (p=0,01 (p=0,0 p<0,0 (p<0,0 (p=0,03 2 p0 p≤0 p=0, (p=0, p<0, (p<0, p≤ p=0 (p=0 p<0 (p<0 p= (p= p< (p< (p

ABSTRACT Objective: to identify the profile of emergency department visits for suicide attempts by adolescents and their associated factors. Method: a cross-sectional, documentary, and retrospective study was conducted with 140 medical records of adolescents treated for suicide attempts in an emergency department linked to a teaching hospital in the municipality of São Paulo, Brazil, between January 2015 and May 2023. Data was collected between August and November 2023. Descriptive and inferential analysis (Pearson’s chi-square test) was performed, considering a p-value≤0.05 as statistically significant. National ethical guidelines were respected. Results: drug intoxications were the most common, associated with females (p<0.001) and continuous use of psychotropic medications (p=0.01). Poisonings were associated with the absence of continuous psychotropic medication use (p=0.02) and treatment in the emergency room (p=0.01). Males were associated with intoxications from alcohol and drugs (p<0.001), wounds from sharp objects (p<0.05), and precipitation (p=0.03). Conclusion: this study found a prevalence of emergency department visits for suicide attempts through intoxications associated with sex, medication use, and treatment in the emergency room. We hope that his profile can help professionals structure action plans to improve clinical care, mental health care, prevention, and post-attempt strategies. Objective factors Method crosssectional, crosssectional cross sectional, sectional cross-sectional documentary 14 Paulo Brazil 201 2023 Pearsons Pearson s chisquare chi square test performed pvalue≤0.05 pvalue005 pvalue p value≤0.05 value 0 05 p-value≤0.0 significant respected Results common p<0.001 p0001 001 (p<0.001 p=0.01. p001 p=0.01 . 01 (p=0.01) p=0.02 p002 02 (p=0.02 p<0.001, , p<0.05, p005 p<0.05 (p<0.05) p=0.03. p003 p=0.03 03 (p=0.03) Conclusion sex care prevention postattempt post attempt strategies 1 20 202 pvalue≤0.0 pvalue00 value005 value≤0.0 p-value≤0. p<0.00 p000 00 (p<0.00 p00 p=0.0 (p=0.01 (p=0.0 p<0.0 (p<0.05 (p=0.03 2 pvalue≤0. pvalue0 value00 value≤0. p-value≤0 (p<0.0 p0 p=0. (p=0. p<0. pvalue≤0 value0 value≤0 p-value≤ (p<0. p=0 (p=0 p<0 pvalue≤ value≤ p-value (p<0 p= (p= p< (p< (p

RESUMEN Objetivo: identificar el perfil de la atención ofrecida en los servicios de emergencia a los adolescentes que intentaron suicidio y factores asociados. Método: estudio transversal, documental y retrospectivo, realizado con 140 historias clínicas de adolescentes atendidos por intento de suicidio en un departamento de urgencias y emergencias, vinculado a un hospital escuela en el municipio de São Paulo, Brasil, entre enero de 2015 y mayo de 2023. Los datos se recopilaron entre agosto y noviembre de 2023. Se realizó un análisis descriptivo e inferencial (prueba de chi-cuadrado de Pearson), considerando un valor de p≤0,05 como diferencia estadística. Se respetaron las directrices éticas nacionales. Resultados: prevalecieron las intoxicaciones medicamentosas, asociadas con el sexo femenino (p<0,001) y el uso de medicamentos psicotrópicos continuos (p=0,01). En las intoxicaciones por veneno, se observó asociación con la ausencia de uso de medicación psicotrópica continua (p=0,02) y la atención en sala de emergencias (p=0,01). El sexo masculino se asoció con intoxicaciones por alcohol y drogas (p<0,001), heridas por arma blanca (p<0,05) y precipitación (p=0,03). Conclusión: en este estudio, se observó una prevalencia de atenciones por intentos de suicidio mediante intoxicaciones asociada a sexo, uso de medicación y atención en sala de emergencias. Se espera que, con este perfil, los profesionales puedan estructurar planes de acción para mejorar la atención clínica, la atención en salud mental y las estrategias de prevención y post-intento. Objetivo asociados Método transversal retrospectivo 14 Paulo Brasil 201 2023 prueba chicuadrado chi cuadrado Pearson, Pearson , Pearson) p005 p 0 05 p≤0,0 estadística nacionales Resultados medicamentosas p<0,001 p0001 001 (p<0,001 p=0,01. p001 p=0,01 . 01 (p=0,01) veneno p=0,02 p002 02 (p=0,02 p<0,001, p<0,05 (p<0,05 p=0,03. p003 p=0,03 03 (p=0,03) Conclusión clínica postintento. postintento post intento. post-intento 1 20 202 p00 p≤0, p<0,00 p000 00 (p<0,00 p=0,0 (p=0,01 (p=0,0 p<0,0 (p<0,0 (p=0,03 2 p0 p≤0 p=0, (p=0, p<0, (p<0, p≤ p=0 (p=0 p<0 (p<0 p= (p= p< (p< (p

ABSTRACT The nutritional profile of ostomized patients acquires special attention due to the conditions that could predispose to malnutrition. The objective of the study was to determine the nutritional profile of ostomized patients who receive outpatient care at the General Hospital of the Second Department of San Pedro-Paraguay Korea, in the year 2022, an observational study of a cross-section was conducted. The data obtained were loaded in an electronic form Microsoft-Excel, for the analysis was used descriptive statistics. To describe the nutritional status of patients, anthropometric indicators and nutritional risk screening (NRS-2002) were used, applied through nutritional clinical interview and evaluation. The study had a global duration of 9 months, 20 ostomized patients were included in the National Program for Comprehensive Care of the Ostomized Patient provided by the General Paraguay-Corea Hospital that complied with the inclusion criteria. Ethical research principles were respected. The most representative age group was 41 to 64 years or more, followed by the age group from 20 to 40 years; Greater proportion of male sex, rural origin. The most frequent type of ostomy was terminal colostomy followed by lateral colostomy; The most frequent base disease was the oncological type, followed by intestinal obstruction, trauma and finally fistulas and diverticular disease. In conclusion, the global appreciation of the nutritional status evaluated by the NRS-2002 tool indicated that the nutritional profile of ostomized patients has a risk of malnutrition in all cases evaluated.

RESUMEN El perfil nutricional de los pacientes ostomizados adquiere especial atención debido a las condiciones que podrían predisponer a una malnutrición. El objetivo del estudio fue determinar el perfil nutricional de pacientes ostomizados que reciben atención ambulatoria en el Hospital General del Segundo Departamento de San Pedro-Paraguay - Corea, en el año 2022, se realizó un estudio observacional de corte transversal. Los datos obtenidos fueron cargados en una planilla electrónica Microsoft-Excel, para el análisis se utilizó estadística descriptiva. Para describir el estado nutricional de los pacientes se emplearon indicadores antropométricos y el Screening de Riesgo Nutricional (NRS-2002), aplicados mediante entrevista y evaluación clínica nutricional. El estudio tuvo una duración global de 9 meses, fueron incluidos 20 pacientes ostomizados atendidos en el Programa Nacional de Atención Integral al Paciente Ostomizado provisto por el Hospital General Paraguay-Corea que cumplieron con los criterios de inclusión. Se respetaron los principios éticos de investigación. El grupo etario más representativo fue el de 41 a 64 años o más, seguido del grupo etario de 20 a 40 años; mayor proporción de sexo masculino, procedencia rural. El tipo de ostomía más frecuente fue colostomía terminal seguido de colostomía laterales; enfermedad de base más frecuente fue el de tipo oncológico, seguida de obstrucción intestinal, trauma y por último fistulas y enfermedad diverticular. En conclusión, la apreciación global del estado nutricional evaluada mediante la herramienta NRS-2002 indicó que el perfil nutricional de los pacientes ostomizados presenta riesgo de malnutrición en todos los casos evaluados.

Resumo Introdução: A mudança na formação dos profissionais de saúde, dentre esses os enfermeiros, tem se tornado urgente em função de diversos determinantes sociais, ambientais, epidemiológicos e de saúde. A constituição do pensamento crítico na prática profissional, na perspectiva dialética, promovendo a emancipação dos sujeitos durante a formação, torna-se potente e fortalece as iniciativas de enfrentamento dos desafios contemporâneos e societários. Objetivo: analisar a representação dos docentes, preceptores e estudantes sobre a constituição das capacidades na prática profissional do enfermeiro por meio do pensamento crítico ao desenvolver o perfil de competência durante a formação. Métodos: qualitativo, entrevista com 24 professores, 09 preceptores e 15 estudantes para reconstrução do perfil de competência na 1ª fase da coleta de dados e oficina de trabalho na 2ª fase para validação do perfil, identificação de desafios e propostas. Utilizou-se o discurso do sujeito coletivo na análise das entrevistas e o referencial de competência holística na reconstrução do perfil. Resultados: Percebe-se que, a proposta curricular trabalha para além de tomar decisões certas e pautadas em evidências. Há de considerar as diversas visões sobre as situações, reconhecer como cada estudante reage, identifica e trabalha com suas emoções, constrói diálogo entre os pares, trabalha coletivamente na resolução dos problemas sempre de forma corresponsável e ética. Há o desafio da desconstrução da competividade e individualismo a serem analisados e superados. Conclusões: as estratégias de investigação, por meio de entrevistas e da oficina de trabalho, ao proporcionar um espaço de reflexão e diálogo, possibilitou a delimitação de quais as capacidades mobilizadas na prática, estabelecidas no perfil de competência do profissional a ser formado na instituição, e como desenvolvê-las por meio do pensamento crítico.

Abstract Introduction: The change in health’s professionals training, including nurses, has become urgent due to various social, environmental, epidemiological and health determinants. The constitution of critical thinking in professional practice, from a dialectical perspective, promoting the emancipation of subjects during training, becomes powerful and strengthens the initiatives to face contemporary and societal challenges. Objective: to analyze the representation of teachers, preceptors, and students about the constitution of capabilities in nurses’ professional practice through critical thinking when developing the competence profile during training. Methods: qualitative, interview with 24 professors, 09 preceptors and 15 students for reconstruction of the competence profile in the 1st phase of data collection and in the 2nd phase workshop for validation of profile, identification of challenges and proposals. The collective subject discourse was used to analyze the interviews and the referential of holistic competence in the reconstruction of the profile. Results: It is deduced that, the curriculum proposal works beyond making certain and evidence-based decisions. It is necessary to consider the different views of situations, recognize how each student reacts, identifies and works with his emotions, builds dialogue among peers, and works collectively to solve problems, always in a co-responsible and ethical way. There is the challenge of deconstructing competitiveness and individualism to be analyzed and overcome. Conclusions: the research strategies, through interviews and the workshop, by providing a space for reflection and dialogue, enabled the delimitation of which capabilities are mobilized in practice, established in the competence profile of the professional to be trained in the institution, and how to develop them through critical thinking.

Worldwide the population of older persons is growing. Relatedly, there is an increasing demand for suitable medical care, social security (e.g. government grants), social services and care. In South Africa, the focus of this study, social services to older persons are mainly provided by two social service professional groups, namely social workers and social auxiliary workers. This paper argues that practitioners in the social service professions must have appropriate knowledge and a fitting attitude towards older persons to provide effective gerontological services. This argument is aligned with an international commitment by signatories to the UN Decade of Healthy Aging 2021-2030 to change the way people think, feel and act towards age and ageing in order to ensure the delivery of integrated person-centred gerontological services. In South Africa, older persons are considered a vulnerable group on which social services must focus (cf. Framework for Social Welfare Services, 2013). There is also specific legislation in this regard, namely the Older Persons Act 13 of 2006, as amended. After consultation of various international and national databases, it was confirmed that, in contrast to various surveys among students in the helping professions, there is still a lack of studies that explore and describe professionals' knowledge of and attitude towards older persons. According to the available literature, there is only one study within the South African context that dealt with the attitude of medical practitioners towards older persons (Ntusi & Ferreira, 2004). With this knowledge gap in mind, the research question that this study seeks to answer is as follows: "What are professionals in social service professions' knowledge of and attitude towards older persons?" This study was undertaken within the ambit of the modernisation theory. A cross-sectional survey was implemented with social service professionals in the employ of a private South African welfare organisation with a footprint over five of the nine provinces. The total population of 140 professionals was invited to complete a web-based survey. Sixty-three respondents (N=63) responded to the invitation and answered the questionnaire in full via QualtricsXM, a web-based programme. Section 1 comprised a holistic profile of the respondents. In Section 2, the knowledge of respondents pertaining to older persons and ageing was determined by means of Palmore's First Facts on Aging Quiz in multiple-choice format. Incorrect answers determine positive or negative bias towards ageing. Section 3 determined the respondents'attitudes towards older persons, using Fraboni's Scale of Ageism. The scale measures overall attitude/ageism, and three sub-scales, namely antilocution, avoidance and discrimination. More specifically, this study determined the impact of nine factors (i.e. age, area of childhood residence, growing up with an older person, qualification, completed course in gerontology, working exclusively with older persons, considering working with older persons, province of employment, and task description) on the knowledge and attitudes of respondents by calculating either the independent T-test or the one-way ANOVA. Both scales were found to be valid and reliable within the South African context. After written permission from the management of the welfare organisation, the research ethics committee of the university provided ethical approval for the study. Based on the profile of the respondents, this study mainly offers a glimpse of female persons in their middle years, with an average of 15 years of experience as social workers and practising in family-centred services. The results show that the respondents have poor overall knowledge of ageing with a mean of 9.4 out of 25 (SD=2.6). In answering the quiz, incorrect answers tended toward negative bias towards older persons. Overall the respondents hold positive attitudes toward older persons with a mean of 80.6 out of 145 (SD=11.8) for ageism. Furthermore, the sub-scales antilocution (x=25.2) and avoidance (x=24.9) scored around the midpoint, while discrimination scored high (x=30.4). Three factors were identified as having a statistically significant impact on the respondents' overall knowledge of ageing: "Age group" (p=0.02), "Qualification" (p=0.03) and "Taskdescription" (p=0.03). Furthermore, "Growing up with an older person in the household" had a statistically significant impact on the subscale "positive bias" (p=0.02). In addition, "Currently working exclusively with older persons" showed a statistically significant impact on both the overall attitude/ageism (p=0.04) and antilocution (p=0.04) measured among the respondents. With reference to the factors that showed a statistically significant impact (p<0.05) on respondents' knowledge of ageing and attitudes towards older persons, recommendations for continuing professional development (CPD) are delineated. As per the policy of the South African Council for Social Service Professions (SACSSP, 2021), registered social workers must achieve at least 20 CPD points each year (or 40 spread over two years) and registered social auxiliary workers 10 points (20 over two years). The policy of the SACSSP makes provision for a variety of group and individual activities whose award of points varies between two and twenty. All professionals also carry out their tasks under a supervisor. Both CPD and supervision offer a familiar context within which social services to older persons can be dealt with. The field of service of professionals should determine the extent to which the focus on older persons should be. In connection with the aforementioned policy and supervision, some recommendations are offered to improve professionals'knowledge of and attitude towards older persons. For example, expert lectures focusing on different aspects of ageing and the completion of professional online development courses. Attitudes could be addressed during individual supervision and with creative activities such as role plays.

Die bejaardebevolking neem wêreldwyd toe. Gevolglik vergroot die vraag na geskikte mediese sorg, maatskaplike bystand, maatskaplike dienste en versorging. In Suid-Afrika word maatskaplike dienste aan ouer persone hoofsaaklik deur twee maatskaplike diensberoepe gelewer, naamlik maatskaplike werkers en maatskaplike hulpwerkers. Hierdie praktisyns moet oor die nodige kennis van en gepaste houding teenoor ouer persone beskik ten einde effektiewe gerontologiese dienste te lewer. Internasionaal, maar ook in Suid-Afrika, is 'n leemte geïdentifiseer met betrekking tot 'n studie wat praktisyns se kennis van en houding teenoor ouer persone verken en beskryf. Hierdie artikel poog om die volgende navorsingsvraag te beantwoord: "Wat is professionele persone in maatskaplike diensberoepe se kennis van en houding teenoor ouer persone?" 'n Deursnit opnameprosedure is gevolg met praktisyns (N=140) verbonde aan een private welsynsorganisasie. Drie-en-sestig respondente (N=63) het die aanlyn vraelys voltooi. Respondente se kennis van veroudering is verken met Palmore 's First Facts on Aging Quiz in multiple-choice format. Houding teenoor ouer persone is ooreenkomstig Fraboni's Scale of Ageism beskryf. Respondente het swak gevaar in hul oorhoofse kennis van veroudering met 'n gemiddelde punt van 9.4 uit 25 (s=2.6). Met 'n teoretiese reikwydte van 29 tot 145, het ouderdomsdiskriminasie laag gemeet (x=80.6; s=11.8). Voorts is die impak van nege faktore op respondente se gemiddelde kennis van en houding teenoor ouer persone bepaal met behulp van parametriese toetse. Beide voortgesette professionele ontwikkelings-inisiatiewe en supervisie is bekende kontekste in maatskaplike diensberoepe. Aanbevelings word gedoen om praktisyns se kennis van en houding teenoor ouer persone te verbeter met die oog op effektiewe gerontologiese dienste.

The movements of humans have a significant impact on population health. While studies of such movements are as old as public health itself, the COVID-19 pandemic has raised the profile of mobility research using digital technologies to track transmission routes and calculate the effects of health policies, such as lockdowns. In sub-Saharan Africa, the high prevalence of cell phone and smartphone use is a source of potentially valuable mobility data for public health purposes. Researchers can access call data records, passively collected in real time from millions of clients by cell phone companies, and associate these records with other data sets to generate insights, make predictions or draw possible policy implications. The use of mobility data from this source could have a range of significant benefits for society, from better control of infectious diseases, improved city planning, more efficient transportation systems and the optimisation of health resources. We discuss key ethical issues raised by public health studies using mobility data from cell phones in sub-Saharan Africa and identify six key ethical challenge areas: autonomy, including consent and individual or group privacy; bias and representativeness; community awareness, engagement and trust; function creep and accountability; stakeholder relationships and power dynamics; and the translation of mobility analyses into health policy. We emphasise the ethical importance of narrowing knowledge gaps between researchers, policymakers and the general public. Given that individuals do not really provide valid consent for the research use of phone data tracking their movements, community understanding and input will be crucial to the maintenance of public trust. SIGNIFICANCE: • Mobility data derived from cell phones are being increasingly used for health research and public health purposes in sub-Saharan Africa, with minimal individual consent and largely without public awareness. • While such data can have significant potential public health benefits, risks and concerns related to their collection and use in sub-Saharan African contexts have not been widely discussed. • Innovative community engagement initiatives, which are appropriate and responsive to sub-Saharan African contexts, need to be developed to address ethical challenge areas and help warrant public trust in mobility research.

Resumo Antecedentes O papel da epilepsia do lobo temporal (ELT) na determinação de traços de personalidade e sintomas neurocomportamentais, coletivamente conhecidos como síndrome comportamental interictal (também conhecida como síndrome de Geschwind ou “síndrome de Gastaut-Geschwind”), bem como a associação da síndrome com o expressão de muitos literatos epilépticos são bem conhecidos em neurologia e psiquiatria. Um aprofundamento da emotividade juntamente com um comportamento sério, altamente ético e espiritual tem sido descrito como mudanças positivas de personalidade em pacientes com ELT mesial crônica. Objetivos A nossa hipótese clínica narrativa visa contribuir para o debate em curso sobre a associação entre ELT e a expressão artística, bem como a suposta implicação desta última para a epilepsia em geral e a neuropsicologia da epilepsia em particular. Métodos Através de uma análise da biografia, linguagem e obra literária do romancista grego Demóstenes Voutyras, levantamos a hipótese de que seu estilo de escrita místico e sombrio poderia ser atribuído à dinâmica interictal temporal medial. Conclusões Sugerimos que o perfil psicoliterário de Voutyras é consistente com as características idiossincráticas da personalidade do lobo temporal, enquanto uma contribuição do lobo temporal não dominante foi proposta. (ELT neurocomportamentais também GastautGeschwind, GastautGeschwind Gastaut , Gastaut-Geschwind”) psiquiatria sério crônica artística particular biografia medial proposta Gastaut-Geschwind” Gastaut-Geschwind

Abstract Background The role of temporal lobe epilepsy (TLE) in determining personality traits and neurobehavioral symptoms, collectively known as the interictal behavioral syndrome (also known as Geschwind syndrome or “Gastaut-Geschwind syndrome”), as well as the syndrome’s association with the particular artistic expression of many epileptic litterateurs are well known in neurology and psychiatry. A deepening of emotionality along with a serious, highly ethical, and spiritual behavior have been described as positive personality changes among patients with chronic mesial-TLE. Objectives Our narrative-based clinical hypothesis aims at contributing to the ongoing debate on the association between TLE and artistic expression, as well as the latter’s supposed implication for epileptology in general and the neuropsychology of epilepsy in particular. Methods Through an analysis of the biography, language, and literary work of Greek novelist Demosthenes Voutyras, we hypothesize that his mystical and dark writing style could be attributed to medial temporal interictal dynamics. Conclusions We suggest that the psycholiterary profile of Voutyras is consistent with the idiosyncratic characteristics of the temporal lobe personality, while a non-dominant temporal lobe contribution has been proposed. (TLE symptoms also GastautGeschwind Gastaut syndrome, , syndrome”) syndromes s psychiatry serious ethical mesialTLE. mesialTLE mesial TLE. mesial-TLE narrativebased narrative based latters latter biography language dynamics nondominant non dominant proposed syndrome”

Resumo Objetivo Identificar a atuação da Fiocruz em estudos clínicos relacionados à Covid-19. Analisar as diferentes terminologias utilizadas para se referir à participação da Fiocruz. Mapear a região desses estudos. Mensurar a quantidade dos estudos aprovados nas plataformas de registro de estudos clínicos e bases ético-regulatórias. Dentre estes, analisar as características metodológicas e de boas práticas dos protocolos dos estudos intervencionais. Métodos Foram revisadas as bases de dados da Agência Nacional de Vigilância Sanitária (ANVISA), Comissão Nacional de Ética em Pesquisa (Conep), Registro Brasileiro de Ensaios Clínicos (ReBEC), ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), US Food and Drug Administration (FDA) e Instituto Nacional de Propriedade Industrial (INPI). Resultados Foram encontrados 53 estudos clínicos sobre Covid-19 com a participação da Fiocruz em 39 destes como instituição proponente. Dentre os 53 estudos, 19 estão em plataformas de registro. Sobre os estudos intervencionais registrados, cinco são de prevenção e nove de tratamento. A intervenção mais analisada nestes estudos foi cloroquina/hidroxicloroquina. Observou-se ainda maior concentração dos estudos clínicos na Região Sudeste, com o total de 37. Conclusão Foram analisadas algumas limitações no delineamento metodológico que podem afetar o alcance dos estudos. Espera-se que os dados obtidos sejam utilizados para orientação futura de estudos clínicos sobre Covid-19 com participação da Fiocruz. Covid19. Covid19 Covid 19. éticoregulatórias. éticoregulatórias ético regulatórias. regulatórias ético-regulatórias estes ANVISA, ANVISA , (ANVISA) Conep, Conep (Conep) ReBEC, ReBEC (ReBEC) ClinicalTrialsgov ClinicalTrials gov ClinicalTrials.gov ICTRP, ICTRP (ICTRP) FDA (FDA INPI. INPI . (INPI) 5 Covid-1 3 proponente 1 registrados tratamento cloroquinahidroxicloroquina cloroquina hidroxicloroquina cloroquina/hidroxicloroquina Observouse Observou Sudeste 37 Esperase Espera Covid1 (ANVISA (Conep (ReBEC (ICTRP (INPI Covid-

Abstract Objective To identify Fiocruz’s performance in clinical studies related to Covid-19. Analyze the different terminologies used to refer to Fiocruz participation. Map the region of these studies. Measure the number of studies approved on clinical study registration platforms and regulatory ethical bases. Analyze the methodological characteristics and good practices of the interventional study protocols. Methods We reviewed databases of Brazilian National Research Ethics Committee, databases of Brazilian National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária - ANVISA), Brazilian Clinical Trials Registry (Registro Brasileiro de Ensaios Clínicos - ReBEC), ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), US Food and Drug Administration (FDA) and Brazilian National Institute of Industrial Property (Instituto Nacional de Propriedade Industrial-INPI). Results 53 clinical studies on Covid-19 were found with the participation of Fiocruz in 39 of them as a proponent institution. Among the 53 studies, 19 are on registration platforms. Of the registered interventional studies, 5 are for prevention and 9 for treatment. The intervention most frequently evaluated in these studies was chloroquine / hydroxychloroquine. There was also a greater concentration of clinical studies in the southeastern region, with a total of 37 studies. Conclusion Some limitations in the methodological design were analyzed, which may affect the scope of the studies. It is expected that the data obtained will be used to guide future clinical studies on Covid-19 with Fiocruz participation. Fiocruzs s Covid19. Covid19 Covid 19. bases protocols Committee Agência ANVISA, ANVISA , ANVISA) Registro ReBEC, ReBEC ReBEC) ClinicalTrialsgov ClinicalTrials gov ClinicalTrials.gov ICTRP, ICTRP (ICTRP) FDA (FDA Instituto IndustrialINPI. IndustrialINPI INPI . Industrial-INPI) Covid-1 3 institution 1 treatment hydroxychloroquine analyzed Covid1 (ICTRP Industrial-INPI Covid-

Resumen Esta investigación rastreó el perfil del Comité de Ética de la Universidad Estadual Vale do Acaraú, Ceará, Brasil, en los 10 años de la Plataforma Brasil. Los estudios ocurrieron entre 2012 y 2021 según actores o procesos, siguiendo el análisis descriptivo. Predominaron mujeres del campo de la salud o las ciencias biológicas y, comparados con los investigadores, los árbitros tenían alto nivel de formación académica, mayor tiempo de experiencia y proyectos. En 2.295 estudios hubo fluctuaciones temporales, con concentración de proyectos aprobados hasta 2015, completados en 2016 y en curso en 2021, con disminución evidente entre 2020-2021. Los estudios más frecuentes provienen de los centros coordinadores, institucionales, brasileños, autoapoyados, sin área temática, con decisión ética favorable hasta tres meses y tiempo de flujo reducido entre quinquenios. El formulario de consentimiento y los riesgos fueron los principales obstáculos éticos. Este panorama valora la importancia de la plataforma al progreso científico. Acaraú Ceará Brasil 1 201 202 procesos descriptivo investigadores académica 2295 2 295 2.29 temporales 2015 20202021. 20202021 2020 2021. 2020-2021 coordinadores institucionales brasileños autoapoyados temática quinquenios éticos científico 20 229 29 2.2 2020202 2020-202 22 2. 202020 2020-20 20202 2020-2 2020-

Resumo Esta pesquisa buscou traçar o perfil do Comitê de Ética da Universidade Estadual Vale do Acaraú, Ceará, nos 10 anos da Plataforma Brasil. Levantaram-se pesquisas realizadas entre 2012 e 2021, conforme atores ou processos, seguindo a análise descritiva. Houve prevalência feminina e do campo da saúde ou ciências biológicas, e pareceristas tiveram maior formação acadêmica, tempo de experiência e número de projetos em relação a pesquisadores. Das 2.295 pesquisas analisadas, houve flutuações temporais, com concentração de projetos anteriormente aprovados até 2015, finalizados em 2016 e em trâmite em 2021, com evidente diminuição em 2020 e 2021. Foram mais frequentes pesquisas originais de centros coordenadores, institucionais, brasileiras, autofinanciadas, sem área temática, com decisão ética favorável, em até três meses e tempo de fluxo reduzido entre quinquênios. Termo de consentimento livre e esclarecido e riscos destacaram-se como principais óbices éticos. Esse panorama valoriza a importância da plataforma para o progresso científico. Acaraú Ceará 1 Brasil Levantaramse Levantaram se 201 2021 processos descritiva biológicas acadêmica pesquisadores 2295 2 295 2.29 analisadas temporais 2015 202 coordenadores institucionais brasileiras autofinanciadas temática favorável quinquênios destacaramse destacaram éticos científico 20 229 29 2.2 22 2.

Abstract This study outlines the profile of the Ethics Committee of the Acaraú Valley State University, Ceará, Brazil, after 10 years of Plataforma Brasil. Bibliographic search surveyed research conducted between 2012 and 2021 according to actors and processes, following descriptive analysis. Results showed a prevalence of female researchers from the health or biological sciences field, and reviewers had a greater academic background, length of experience, and number of projects than researchers. Of the 2,295 studies analyzed, most were approved by 2015, completed in 2016 and under evaluation in 2021, with clear decrease in 2020 and 2021. Original research from national self-funded institutional coordinating centers without thematic area, with a favorable ethical opinion within three months, and reduced flow time between quinquennia stood out. Main ethical obstacles concerned the informed consent and risks. This overview highlights the importance of the platform for scientific progress. University Ceará Brazil 1 Brasil 201 202 processes analysis field background experience 2295 2 295 2,29 analyzed 2015 selffunded self funded area months out risks progress 20 229 29 2,2 22 2,

RESUMEN El estudio verificó cómo la enseñanza para la sostenibilidad se ha aplicado en el aprendizaje de los estudiantes brasileños de educación superior. Desde la perspectiva de la Segunda Mejor Teoría, se analizó la presencia de temas relacionados con los Objetivos de Desarrollo Sostenible de Naciones Unidas en Exame Nacional de Desempenho dos Estudantes. Presenta un enfoque cualitativo y cuantitativo utilizando técnicas de análisis de contenido. El método de investigación documental ayudó en la recolección de ordenanzas y lineamientos del Ministerio de Educación, así como las pruebas aplicadas en el período de 2004 a 2018. Se concluye que ya existía una preocupación por el tema en las pruebas de Exame Nacional de Desempenho dos Estudantes y que Los estudiantes deben tener un perfil ético comprometido con los temas sociales, culturales y ambientales. Si bien es difícil medir la consolidación del pensamiento y las habilidades de los estudiantes adquiridas en los años de estudio, la investigación contribuyó a reforzar que las acciones de las instituciones educativas son relevantes para ampliar el compromiso con los Objetivos de Desarrollo Sostenible. superior Teoría contenido Educación 200 2018 sociales ambientales 20 201 2

RESUMO O estudo verificou como o ensino para a sustentabilidade tem sido aplicado na aprendizagem de alunos brasileiros do ensino superior. Na perspectiva da Teoria do Segundo Melhor, foi analisada a presença de temas relacionados aos Objetivos de Desenvolvimento Sustentável das Nações Unidas no Exame Nacional de Desempenho dos Estudantes. Apresenta uma abordagem qualitativa e quantitativa utilizando técnicas de análise de conteúdo. O método de pesquisa documental auxiliou na coleta das portarias e diretrizes do Ministério da Educação, bem como das provas aplicadas no período de 2004 a 2018. Conclui-se que já havia uma preocupação com o tema nas provas do Exame Nacional de Desempenho dos Estudantes e que os alunos deveriam ter um perfil ético e comprometido com as questões sociais, culturais e ambientais. Embora seja difícil mensurar a consolidação do pensamento do aluno e das competências adquiridas nos anos de estudo, a pesquisa contribuiu para reforçar que as ações das instituições de ensino são relevantes na ampliação do compromisso com os Objetivos de Desenvolvimento Sustentável. superior Melhor conteúdo Educação 200 2018 Concluise Conclui se sociais ambientais 20 201 2

ABSTRACT The study verified how teaching for sustainability has been applied in the learning of Brazilian higher education students. From the perspective of the Second Best Theory, the presence of themes related to the United Nations Sustainable Development Goals in Exame Nacional de Desempenho dos Estudantes was analyzed. It presents a qualitative and quantitative approach using content analysis techniques. The documentary research method helped in the collection of ordinances and guidelines of the Ministry of Education, as well as the tests applied in the period from 2004 to 2018. It is concluded that there was already a concern with the topic in the Exame Nacional de Desempenho dos Estudantes tests and that students should have an ethical profile committed to social, cultural, and environmental issues. Although it is difficult to measure the consolidation of student thinking and skills acquired in the years of study, the research contributed to reinforce that the actions of educational institutions are relevant in expanding the commitment to the Sustainable Development Goals. Theory analyzed techniques Education 200 2018 social cultural issues 20 201 2

Abstract Objective To identify Fiocruz’s performance in clinical studies related to Covid-19. Analyze the different terminologies used to refer to Fiocruz participation. Map the region of these studies. Measure the number of studies approved on clinical study registration platforms and regulatory ethical bases. Analyze the methodological characteristics and good practices of the interventional study protocols. Methods We reviewed databases of Brazilian National Research Ethics Committee, databases of Brazilian National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária - ANVISA), Brazilian Clinical Trials Registry (Registro Brasileiro de Ensaios Clínicos - ReBEC), ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), US Food and Drug Administration (FDA) and Brazilian National Institute of Industrial Property (Instituto Nacional de Propriedade Industrial-INPI). Results 53 clinical studies on Covid-19 were found with the participation of Fiocruz in 39 of them as a proponent institution. Among the 53 studies, 19 are on registration platforms. Of the registered interventional studies, 5 are for prevention and 9 for treatment. The intervention most frequently evaluated in these studies was chloroquine / hydroxychloroquine. There was also a greater concentration of clinical studies in the southeastern region, with a total of 37 studies. Conclusion Some limitations in the methodological design were analyzed, which may affect the scope of the studies. It is expected that the data obtained will be used to guide future clinical studies on Covid-19 with Fiocruz participation.

Resumo Objetivo Identificar a atuação da Fiocruz em estudos clínicos relacionados à Covid-19. Analisar as diferentes terminologias utilizadas para se referir à participação da Fiocruz. Mapear a região desses estudos. Mensurar a quantidade dos estudos aprovados nas plataformas de registro de estudos clínicos e bases ético-regulatórias. Dentre estes, analisar as características metodológicas e de boas práticas dos protocolos dos estudos intervencionais. Métodos Foram revisadas as bases de dados da Agência Nacional de Vigilância Sanitária (ANVISA), Comissão Nacional de Ética em Pesquisa (Conep), Registro Brasileiro de Ensaios Clínicos (ReBEC), ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), US Food and Drug Administration (FDA) e Instituto Nacional de Propriedade Industrial (INPI). Resultados Foram encontrados 53 estudos clínicos sobre Covid-19 com a participação da Fiocruz em 39 destes como instituição proponente. Dentre os 53 estudos, 19 estão em plataformas de registro. Sobre os estudos intervencionais registrados, cinco são de prevenção e nove de tratamento. A intervenção mais analisada nestes estudos foi cloroquina/hidroxicloroquina. Observou-se ainda maior concentração dos estudos clínicos na Região Sudeste, com o total de 37. Conclusão Foram analisadas algumas limitações no delineamento metodológico que podem afetar o alcance dos estudos. Espera-se que os dados obtidos sejam utilizados para orientação futura de estudos clínicos sobre Covid-19 com participação da Fiocruz.

Resumen Objetivo: analizar la percepción de los usuarios de las redes sociales sobre el uso de sistemas de IA en el campo de la salud y aspectos bioéticos asociados a este uso. Método: método mixto, del tipo descriptivo-exploratorio. El camino metodológico se dividió en dos etapas: (1) recopilación de información sobre los principales aspectos bioéticos involucrados en el uso de la IA y (2) elaboración de escenarios para la toma de decisiones. Los datos cuantitativos se analizaron mediante estadística descriptiva para caracterizar la muestra desde el punto de vista sociodemográfico, así como para caracterizar el perfil de toma de decisiones de la muestra con respecto a cuestiones bioéticas asociadas al uso de sistemas de IA. El análisis de datos cualitativos se realizó utilizando el análisis de contenido de Bardin. Resultados: en el perfil sociodemográfico se observa una muestra de mujeres adultas con título universitario. En cuanto a las preocupaciones éticas asociadas a los escenarios aplicados, las principales preocupaciones fueron en primer lugar la privacidad y confidencialidad de los datos, seguidas de las preocupaciones relacionadas con la responsabilidad asociada al uso de estas tecnologías, así como el consentimiento informado. Conclusión: De esta forma, se destaca la importancia de nuevos estudios empíricos exploratorios como este, que evalúen la percepción, actitudes y opiniones de públicos especializados, como profesionales de la salud, derecho, humanidades, con el fin de obtener evidencias concretas para el desarrollo. de programas de gestión y gobernanza de los sistemas de IA, especialmente en el escenario brasileño, donde los recursos son escasos.

Abstract Objective: to analyze the perception of users of social networks regarding the use of AI systems in the field of health and the bioethical aspects associated with this use. Method: Mixed method study, of the descriptive-exploratory type. The methodological path was divided into two stages: (1) gathering information about the main bioethical aspects involved in the use of AI and (2) elaboration of decision-making scenarios. Quantitative data were analyzed using descriptive statistics in order to characterize the sample from a sociodemographic point of view, as well as to characterize the sample's decision-making profile regarding bioethical issues associated with the use of AI systems. Qualitative data analysis was performed using Bardin's content analysis. Results: with regard to the sociodemographic profile, a sample of female adults with a university degree can be observed. With regard to the ethical concerns associated with the applied scenarios, the main concerns were in the first place the privacy and confidentiality of the data, followed by concerns related to the responsibility associated with the use of these technologies, as well as informed consent. Conclusion: In this way, the importance of new exploratory empirical studies like this one is highlighted, evaluating the perception, attitudes and opinions of specialized audiences, such as professionals in the health, law, humanities, in order to obtain concrete evidence to the development of management and governance programs for AI systems, especially in the Brazilian scenario, where resources are scarce.

Resumo Objetivo: analisar a percepção de usuários de redes sociais a respeito da utilização de sistemas de IA no campo da saúde e os aspectos bioéticos associados a essa utilização. Método: Estudo de método mistos, do tipo descritivo-exploratório. O percurso metodológico foi dividido em duas etapas: (1) levantamento de informação a respeito dos principais aspectos bioéticos envolvidos na utilização de IA e (2) elaboração dos cenários de tomada de decisão. Os dados quantitativos foram analisados por meio de estatística descritiva a fim de caracterizar a amostra do ponto de vista sociodemográfico, bem como caracterizar o perfil de tomada de decisão da amostra com relação às questões bioéticas associadas à utilização de sistemas de IA. A análise dos dados qualitativos foi realizada por meio da análise de conteúdo de Bardin. Resultados: com relação ao perfil sociodemográfico pode-se observar uma amostra de adultos, do sexo feminino, com curso superior completo. Com relação às preocupados éticas associadas aos cenários aplicados, as principais preocupações foram em primeiro lugar a privacidade e confidencialidade dos dados, seguido de preocupações relacionadas à responsabilidade associada a utilização destas tecnologias, bem como ao consentimento informado. Conclusão: Desta forma, destaca-se a importância de novos estudos empíricos exploratórios como este, avaliando a percepção, atitudes e opiniões de públicos especializados, como profissionais da área da saúde, do direito, das humanidades, a fim de se obter evidências concretas para a elaboração de programas de gestão e governança dos sistemas de IA, sobretudo no cenário brasileiro, de escassez de recursos.

Resum Objectiu: analitzar la percepció dels usuaris de les xarxes socials sobre l'ús de sistemes d'IA al camp de la salut i els aspectes bioètics associats a aquest ús. Mètode: Estudi de mètode mixt, del tipus descriptiu-exploratori. El camí metodològic es va dividir en dues etapes: (1) recopilació d'informació sobre els aspectes bioètics principals involucrats en l'ús de la IA i (2) elaboració d'escenaris per a la presa de decisions. Les dades quantitatives es van analitzar mitjançant estadística descriptiva per caracteritzar la mostra des del punt de vista sociodemogràfic, així com per caracteritzar el perfil de presa de decisions de la mostra pel que fa a qüestions bioètiques associades a l'ús de sistemes d'IA. L'anàlisi de dades qualitatives es va fer utilitzant l'anàlisi de contingut de Bardin. Resultats: quant al perfil sociodemogràfic, es pot observar una mostra de dones adultes amb títol universitari. Pel que fa a les preocupacions ètiques associades als escenaris aplicats, les principals preocupacions van ser en primer lloc la privadesa i confidencialitat de les dades, seguides de les preocupacions relacionades amb la responsabilitat associada a l'ús d'aquestes tecnologies, així com el consentiment informat. Conclusió: D'aquesta manera, es destaca la importància de nous estudis empírics exploratoris com aquest, que avaluïn la percepció, actituds i opinions de públics especialitzats, com a professionals de la salut, dret, humanitats, per tal d'obtenir evidències concretes per al desenvolupament . programes de gestió i governança dels sistemes d'IA, especialment a l'escenari brasiler, on els recursos són escassos.

Resumen Los cuidados paliativos (CP) de las mascotas es un tema emergente en medicina veterinaria que constituye una alternativa terapéutica para la eutanasia temprana. Nuestro objetivo fue avaluar la perspectiva, los criterios, los procedimientos y las referencias éticas y científicas de los CP y la eutanasia en las mascotas, probando la hipótesis de las diferencias en las perspectivas de la eutanasia y los CP, así como entre los escenarios nacionales e internacionales. Con este fin, se realizó una revisión bibliográfica integradora de la producción científica y un recorte del análisis jurisprudencial de los reflejos legales en la actividad médica veterinaria. La revisión integradora dio como resultado 535 artículos, de los cuales 43 cumplieron con los criterios de inclusión, más 800 resúmenes de procesos, que el 30% estaban relacionados con acciones de indemnización contra servicios veterinarios y médicos. Los datos obtenidos, bajo el recorte propuesto en la investigación, se permiten caracterizar el enfoque científico de CP y eutanasia, así como lanzar senderos interpretativos de cómo los aspectos funcionales y las perspectivas de aplicación pueden subsidiar las decisiones del equipo médico veterinario y aquellos responsables de animales. Sin embargo, para superar las limitaciones y la consolidación de las potencialidades de CP, se requiere un esfuerzo multidimensional que incluya la esfera normativa, técnica, social y ética. Se vislumbra la recepción del problema en la agenda de la bioética, lo que sugiere que se realiza en el espacio multidisciplinario del Comité de Bioética del Hospital Veterinario para ayudar en la deliberación de las decisiones de conflicto considerando el derecho a proporcionar una vida digna al animal y, en consecuencia, mitigando las vulnerabilidades comprometedoras del derecho a vivir y morir.

Abstract Palliative care (PC) of pets is an emerging theme in veterinary medicine constituting a therapeutic alternative for early euthanasia. Our objective was to map of the perspective, criteria, procedures and ethical and scientific references of PC and euthanasia in pets, testing the hypothesis of differences in the perspectives of euthanasia and PC, as well as between the national and international scenarios. Thus, an integrative bibliographic review of scientific production and a cut of jurisprudential analysis of legal reflexes in veterinary medical activity was performed. The integrative review resulted in 535 articles, of which 43 complied with the inclusion criteria, agree with 800 actions, which 30% were related to indemnity actions against veterinary services. The data obtained, under the profile proposed in the research, allowed to characterize the scientific approach of PC and euthanasia, as well as launch interpretative trails of how functional aspects and prospects of application can subsidize the decisions of the veterinary medical team and those responsible for animals. However, to overcome the limitations and the consolidation of PC potentialities, a multidimensional effort is required including the normative, technical, social and ethical sphere. We discern the reception of the issue in the agenda of bioethics suggesting that it is performed in the multidisciplinary space of the veterinary hospital bioethics committee to assist in the deliberation of conflict decisions considering the right to provide a dignified life to the animal, and consequently, mitigating compromising vulnerabilities of the right to live and die.

Resumo Os cuidados paliativos (CP) de animais de estimação constituem um tema emergente na Medicina Veterinária se caracterizando como uma alternativa terapêutica para a eutanásia precoce. Objetivou-se mapear a perspectiva, critérios, procedimentos e referenciais éticos e científicos dos CP e da eutanásia em animais de estimação, testando a hipótese de diferenças nas perspectivas da eutanásia e dos CP, bem como entre os cenários nacional e internacional. Para tal, realizou-se uma revisão bibliográfica integrativa da produção científica e um recorte de análise jurisprudencial a respeito dos reflexos jurídicos na atividade médico-veterinária. A revisão integrativa resultou em 535 artigos, dos quais 43 atenderam aos critérios de inclusão, acrescida de 800 ementas, as quais 30% foram relativas a ações indenizatórias contra serviços e médicos veterinários. Os dados obtidos, sob o recorte proposto na pesquisa, permitiram caracterizar a abordagem científica dos CP e da eutanásia, bem como lançar trilhas interpretativas de como os aspectos funcionais e perspectivas de aplicação podem subsidiar as decisões da equipe médica veterinária e dos responsáveis pelos animais. Contudo, para superação das limitações e a consolidação das potencialidades dos CP se faz necessário um esforço multidimensional, incluindo a esfera normativa, técnica, social e ética. Vislumbra-se o acolhimento da questão nas pautas da Bioética sugerindo que seja performada no espaço multidisciplinar do Comitê de Bioética Hospitalar Veterinário, com intuito de auxiliar na deliberação de decisões conflituosas, considerando o direito de proporcionar uma vida digna ao animal e, consequentemente, mitigando vulnerabilidades comprometedoras do direito de viver e de morrer.

Resum Les cures pal·liatives (CP) de les mascotes és un tema emergent en medicina veterinària que constitueix una alternativa terapèutica per a l'eutanàsia primerenca. El nostre objectiu va ser avaluar la perspectiva, els criteris, els procediments i les referències ètiques i científiques dels CP i l'eutanàsia a les mascotes, provant la hipòtesi de les diferències en les perspectives de l'eutanàsia i els CP, així com entre els escenaris nacionals i internacionals. Amb aquesta finalitat, es va fer una revisió bibliogràfica integradora de la producció científica i una retallada de l'anàlisi jurisprudencial dels reflexos legals a l'activitat mèdica veterinària. La revisió integradora va donar com a resultat 535 articles, 43 dels quals van complir els criteris d'inclusió, més 800 resums de processos, que el 30% estaven relacionats amb accions d'indemnització contra serveis veterinaris i mèdics. Les dades obtingudes, sota la retallada proposada a la investigació, es permeten caracteritzar l'enfocament científic de CP i eutanàsia, així com llançar senders interpretatius de com els aspectes funcionals i les perspectives d'aplicació poden subsidiar les decisions de l'equip mèdic veterinari i els responsables de animals. Tot i això, per superar les limitacions i la consolidació de les potencialitats de CP, es requereix un esforç multidimensional que inclogui l'esfera normativa, tècnica, social i ètica. S'entreveu la recepció del problema a l'agenda de la bioètica, cosa que suggereix que es realitza a l'espai multidisciplinari del Comitè de Bioètica de l'Hospital Veterinari per ajudar en la deliberació de les decisions de conflicte considerant el dret a proporcionar una vida digna a l'animal i, en conseqüència, mitigant les vulnerabilitats comprometedores del dret a viure i morir.

BACKGROUND: The World Health Organization (WHO) guidelines recommend the empiric treatment of infections before definitive treatment begins. However, ethical concerns limit the availability of clinical trials in neonates and paediatrics to fully ascertain the safety profile of antibiotics in these populations. AIM: This study aimed to quantify the use of antibiotics among neonates and paediatrics and commented on the use, rationale and appropriateness of antibiotics prescribed. SETTING: A secondary level public sector hospital located in Durban, KwaZulu-Natal. METHODS: Demographic and treatment information of neonates and paediatrics were collected retrospectively from January 2022 to June 2022. Data were obtained from patient files and extracted for analysis using Microsoft Excel®. Analytical and descriptive statistics were used to analyse patient demographics and treatment variables. RESULTS: A total of 568 antibiotics, issued to 389 patients, were reviewed. Penicillins (40.1%), aminoglycosides (24.3%) and combination penicillin-beta-lactam inhibitors (23.3%) were identified as the most frequently prescribed antibiotics for inpatients. Most antibiotics prescribed to inpatients were for complications associated with pre-term birth (66.9%). Combination penicillin-beta-lactam inhibitors (34.7%), penicillins (29.5%) and cephalosporins (29.5%) were the most frequently prescribed antibiotics to outpatients. A correlation was found between the route of administration and the duration of therapy; the intravenous route (63.6%) was preferred over the oral route (36.4%) for administration. CONCLUSION: Many broad-spectrum antibiotics were prescribed, thus increasing the risk of resistance. Antibiotics were being prescribed according to the guidelines; however, there is still a need for therapeutic drug monitoring to ensure the continuation of rational drug use. CONTRIBUTION: There was evidence of rational use of antibiotics in the public hospital (KwaZulu-Natal), in keeping with economic and availability factors.