Abstract (Introduction): Within the framework of the present capitalist system, human beings have become an important polluting agent. Current production and consumption processes do not consider the existence of finite natural resources and a planet incapable of treating the waste that the prevailing way of life generates. Given these circumstances, the study of non-linear models is of interest, which make a more rational use of the waste that the productive activity generates, favoring recycling mechanisms. The phenomenon of recycling becomes particularly relevant in the case of electrical and electronic devices, whose ability to be degraded and metabolized by planet Earth is extremely difficult. (Objective): Evaluate the feasibility of installing and starting a recycling plant for electrical and electronics items in the town of Bahía Blanca (Argentina), during 2021. (Methodology): The conventional method for evaluating investment projects was used, considering technical, legal and economic aspects. (Results): The project is not acceptable according to the profitability intended by the investor. The possibility of financing was also included, which made the project even less profitable, and the sensitivity of the results was measured, finding that the price should be 1.48 % higher than that used in the analysis. (Conclusions): Other alternatives must be explored to make this proposal profitable from an economic and financial point of view.

Resumen (Introducción): En el marco del sistema capitalista vigente, el ser humano se ha transformado en un agente significativo de contaminación. Las dinámicas productivas y de consumo actuales no contemplan la existencia de recursos naturales finitos y de un planeta incapaz de procesar los desperdicios que el modo de vida habitual genera. Dadas estas circunstancias, cobra interés el estudio de modelos no lineales, que hagan un uso más racional de los residuos derivados de la actividad productiva, los cuales favorezcan mecanismos de reciclaje. El fenómeno del reciclaje se vuelve, en particular, relevante para el caso de los artefactos eléctricos y electrónicos; la capacidad del planeta Tierra para degradarlos y metabolizarlos resulta sumamente difícil. (Objetivo): Evaluar la factibilidad de la instalación y puesta en marcha de una planta recicladora de artículos eléctricos y electrónicos en la localidad de Bahía Blanca (Argentina), durante el 2021. (Metodología): Se utilizó la metodología convencional de evaluación de proyectos de inversión, considerando aspectos técnicos, legales y económicos. (Resultados): El proyecto no es aceptable según la rentabilidad pretendida por el inversor. También se incluyó la posibilidad de un financiamiento, lo que hizo que el plan fuera menos rentable aún, y se midió la sensibilidad de los resultados: se halló que el precio debiera ser 1.48 % superior al utilizado en el análisis. (Conclusiones): Se deben explorar otras alternativas para lograr que el proyecto sea rentable desde el punto de vista económico-financiero.

RESUMO Objetivo: Identificar e caracterizar a população de casos pediátricos encaminhados para o nosso centro de oxigenoterapia hiperbárica. Métodos: Estudo retrospetivo e observacional, que incluiu doentes pediátricos tratados com oxigenoterapia hiperbárica, de 2006 a 2021, no centro de referência de medicina hiperbárica do norte de Portugal. As variáveis de interesse foram extraídas dos processos clínicos eletrônicos. Resultados: O nosso estudo incluiu 134 casos. Os motivos de encaminhamento mais frequentes foram intoxicação por monóxido de carbono (n=59) e surdez súbita neurossensorial (n=41). Em 75 casos (56%) o tratamento foi iniciado em contexto de urgência. Os sintomas de apresentação à admissão variaram entre os diferentes casos, sendo os mais frequentes cefaleias e náuseas/vômitos. No que diz respeito à intoxicação por monóxido de carbono, as fontes mais comuns foram o aquecedor, lareira/braseiro e caldeira. Com relação aos efeitos adversos, foram identificados um caso de intoxicação por oxigênio e quatro casos de barotrauma do ouvido médio. Conclusões: A causa mais frequente de encaminhamento foi a intoxicação por monóxido de carbono. Todos os pacientes evoluíram favoravelmente e foram registrados poucos efeitos adversos, o que enfatiza a segurança desta terapia. Uma vez que a maioria dos pediatras pode não estar informada sobre os potenciais benefícios da oxigenoterapia hiperbárica, é de extrema importância promovê-los para que esta técnica seja cada vez mais implementada. Objetivo Métodos observacional 200 2021 Portugal eletrônicos Resultados 13 n=59 n59 n 59 (n=59 n=41. n41 n=41 . 41 (n=41) 7 56% 56 (56% urgência náuseasvômitos náuseas vômitos náuseas/vômitos aquecedor lareirabraseiro lareira braseiro caldeira adversos médio Conclusões terapia promovêlos promovê los implementada 20 202 1 n=5 n5 5 (n=5 n4 n=4 4 (n=41 (56 2 n= (n= (n=4 (5 (n (

ABSTRACT Objective: To identify and characterize the population of Pediatric patients referred to our hyperbaric oxygen therapy center. Methods: Retrospective and observational study, including pediatric patients treated with hyperbaric oxygen therapy, from 2006 to 2021, at the hyperbaric medicine reference center in the north of Portugal. Variables of interest were extracted from electronic medical records. Results: Our study included 134 patients. The most frequent reasons for referral were carbon monoxide poisoning (n=59) and sudden sensorineural hearing loss (n=41). In 75 cases (56%), treatment was initiated in an urgent context. Symptom presentation at Emergency Department varied among patients, the most frequent being headache and nausea/vomiting. Concerning carbon monoxide poisoning, the most common sources were water heater, fireplace/brazier, and boiler. Regarding adverse effects, it was identified one case of intoxication by oxygen and four cases of middle ear barotrauma. Conclusions: The most frequent cause for referral was carbon monoxide poisoning. All patients evolved favorably, with few side effects being reported, emphasizing the safety of this therapy. While most pediatricians may not be aware of the potential benefits arising with hyperbaric oxygen therapy, it is of upmost importance to promote them, so that this technique is increasingly implemented. Objective Methods 200 2021 Portugal records Results 13 n=59 n59 n 59 (n=59 n=41. n41 n=41 . 41 (n=41) 7 56%, 56 56% , (56%) context nauseavomiting nausea vomiting nausea/vomiting heater fireplacebrazier fireplace brazier fireplace/brazier boiler barotrauma Conclusions favorably reported them implemented 20 202 1 n=5 n5 5 (n=5 n4 n=4 4 (n=41 (56% 2 n= (n= (n=4 (56 (n (5 (

ABSTRACT Purpose: To evaluate the predictive value of initial intraocular pressure difference of the detached and fellow eyes of patients with complex rhegmatogenous retinal detachment on postoperative persistent ocular hypotony. Methods: This retrospective observational study included 538 eyes of 538 unilateral complex rhegmatogenous retinal detachment patients with a proliferative vitreoretinopathy grade of C-1 or higher, treated with silicone oil endotamponade following pars plana vitrectomy. The patients were divided into Group A (patients having silicone oil removal without ocular hypotony; n=504) and Group B (patients with persistent ocular hypotony following silicone oil removal [n=8, 23.5%] and with retained silicone oil [n=26, 76.5%] due to the risk of persistent ocular hypotony; total n=34). Ocular hypotony was defined as an intraocular pressure of <6 mmHg on two or more occasions. Patients’ demographics, including age, sex, and follow-up time, and ocular characteristics, including ocular surgical and trauma history, initial and final best-corrected visual acuity, intraocular pressure and initial intraocular pressure difference of the detached and fellow eyes, and anatomical success rates and postoperative complications, were retrospectively collected from the electronic patient files. Results: The initial intraocular pressure was significantly lower in the detached eyes of Group B than in Group A (8.3 ± 3.5 vs. 12.9 ± 3.3, p<0.001). Also, the initial intraocular pressure difference was significantly higher in Group B than in Group A (8.9 ± 3.2 vs. 2.2 ± 2.7mmHg, p<0.001). The receiver operating characteristic curve analysis showed that the cutoff value of the initial intraocular pressure difference was 7.5mmHg for the risk of persistent ocular hypotony. The most influential factors on postoperative persistent ocular hypotony in the binary logistic regression analysis were the initial intraocular pressure difference and the need for a retinectomy. Conclusion: In eyes with complex rhegmatogenous retinal detachment treated with pars plana vitrectomy and silicone oil tamponade, the initial intraocular pressure difference could be of value in predicting postoperative persistent ocular hypotony and could guide surgeons on the decision of silicone oil removal. Purpose Methods 53 C1 C 1 C- n=504 n504 n 504 n=8, n8 8 [n=8 23.5% 235 23 5 n=26, n26 26 [n=26 76.5% 765 76 n=34. n34 n=34 . 34 n=34) 6 < occasions Patients demographics age sex followup follow up time characteristics history bestcorrected best corrected acuity complications files Results 8.3 83 3 (8. 35 3. vs 129 12 9 12. 33 3.3 p<0.001. p0001 p p<0.001 0 001 p<0.001) Also 8.9 89 32 2 22 2. 27mmHg 7mmHg 2.7mmHg 75mmHg 7 5mmHg retinectomy Conclusion tamponade n=50 n50 50 n=8 [n= 23.5 n=26 n2 [n=2 76.5 n3 n=3 8. (8 p000 p<0.00 00 n=5 n5 n= [n 23. n=2 76. ( p00 p<0.0 p0 p<0. p<0 p<

ABSTRACT Purpose: This study aimed to evaluate the perception and degree of satisfaction of blind individuals regarding an electronic cane prototype with a wearable haptic interface. Methods: Two scenarios with different obstacles were created to conduct tests with the canes (the user’s cane and the prototype one). The perception and satisfaction of participants regarding the electronic cane were assessed using a questionnaire, the number of collisions during the tests, and the time each individual took to complete the course in each scenario. Results: Ten blind individuals who used the white cane participated in this study. Eight were males, and two were females. Their age ranged from 23 to 43 (average 32.3 ± 7.13 years and median 32 years). There was a tendency for fewer collisions with ground obstacles when the electronic cane was used than when the white cane was used. However, there was no statistically significant difference between the number of collisions and the course completion time in each scenario with either canes tested. Conclusion: Overall, the perception and satisfaction of individuals regarding the prototype used were positive. Purpose interface Methods users user s one. one . one) questionnaire Results males females 2 4 average 323 3 32. 713 7 13 7.1 years. years) However tested Conclusion Overall positive 71 1 7.

Asphaltenes are complex molecules with a tendency to aggregate. This property can be an issue for the oil industry due to CO2 reinjection into reservoirs to mitigate these gas emissions. The present theoretical study aimed to study the CO2 interaction with no-substitute and substituted coronene as an asphaltene model compound at CAM-B3LYP-D3/6-311G(d,p) level. The electronic properties were evaluated using harmonic oscillator model of aromaticity (HOMA), quantum theory of atoms in molecules (QTAIM), and reduced density gradient (RDG) methods. The results showed that the coronene’s functionalization by a sulfur atom changes the coronene’s electronic structure. However, functionalization does not change the type of interactions between the monomers, as they remain predominantly van der Waals interactions. CO2 interaction with substituted coronene barely changed due to the presence of sulfur atoms. However, in dimers, the position of the heteroatom directly influences the interaction with CO2, although it is insufficient to change the interaction’s magnitude. For this reason, our results indicate that the sulfur heteroatom in asphaltenes should be addressed. However, new studies must be conducted by increasing the number of substituents, CO2 numbers, and the model size. aggregate CO emissions nosubstitute no substitute CAMB3LYPD3/6311Gd,p CAMB3LYPD36311Gdp CAMBLYPDGdp CAM B3LYP D3/6 311G d,p D3 6 d p B LYP D G CAM-B3LYP-D3/6-311G(d,p level HOMA, HOMA , (HOMA) QTAIM, QTAIM (QTAIM) RDG (RDG methods coronenes s structure However monomers dimers magnitude reason addressed substituents numbers size CAMB3LYPD3 6311Gd CAMB LYPD Gd Gdp BLYP D36 D3/ dp (HOMA (QTAIM CAMBLYPD CAMB3LYPD

Alzheimer’s disease (AD) is a most common form of dementia and results in memory loss, disorientation, impaired thinking and changes in personality as well as mood. The dementia cases mostly turn into the Alzheimer’s disease (AD). Another disease, the Parkinson’s disease (PD), mainly affects dopaminergic neurons in substantia nigra. A series of previously synthesized quinolone-triazole hybrids were investigated and evaluated for their anti-acetyl cholinesterase and against monoamine oxidase reactive properties through in silico characterization. The ground state electronic properties were determined by electron density of the compounds through DFTs (density functional theory) calculation. The geometries of all compounds were optimized using Becke-3-parameter-Lee-Yang-Parr (B3LYP) method and 6-311g basis set. Docking studies were conducted using the AutoDock and Molecular Operating Environment (MOE) software and the results of the potent derivatives found to be encouraging. The data confirmed that all the compounds have drug-like properties and was further confirmed by ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. Alzheimers Alzheimer s AD (AD loss disorientation mood AD. . Parkinsons Parkinson PD, PD , (PD) nigra quinolonetriazole quinolone triazole antiacetyl anti acetyl characterization theory calculation Becke3parameterLeeYangParr BeckeparameterLeeYangParr Becke 3 parameter Lee Yang Parr B3LYP BLYP B LYP (B3LYP 6311g g 6 311g set MOE (MOE encouraging druglike drug like absorption, absorption (absorption distribution metabolism toxicity (PD parameterLeeYangParr

RESUMO Objetivo: Avaliar a validade preditiva e o ponto de corte da frequência cardíaca e da pressão arterial nas alterações da variabilidade da frequência cardíaca (VFC) em crianças com e sem obesidade. Métodos: Foram incluídas 125 crianças neste estudo, sendo 41 com peso normal e 84 com obesidade. Antropometria, pressão arterial, frequência cardíaca e VFC foram medidas por meio de balança eletrônica e estadiômetro, esfigmomanômetro e monitor de VFC. Além disso, a curva característica de operação do receptor (ROC) foi obtida pela análise estatística dos dados. Resultados: A frequência cardíaca mostrou-se um bom preditor de alterações no parâmetro de raiz quadrada da média do quadrado das diferenças entre os intervalos NN consecutivos (RMSSD) em escolares de ambos os sexos para o grupo de peso normal (ROC 0,89; IC95% 0,77–1,00) e obesidade (ROC 0,90; IC95% 0,83–0,97). Além disso, o ponto de corte da frequência cardíaca para alterações no parâmetro RMSSD para meninos com peso normal foi de 93 bpm (sensibilidade 100,00% e especificidade 87,50%), e para meninos com obesidade, o ponto de corte estabelecido foi de 91 bpm (sensibilidade 94,74% e especificidade 63,64%). A frequência cardíaca também se mostrou um bom preditor considerando os índices da relação baixa frequência/alta frequência (LF/HF) e razão desvio padrão de intervalos NN contínuos de longo prazo/desvio padrão da variabilidade instantânea de intervalos NN contínuos na relação gráfica de Poincaré (SD2/SD1). As pressões arteriais sistólicas e diastólicas foram bons preditores em estratificações mais específicas e, portanto, podem ser utilizadas em alguns casos. Conclusões: A validade preditiva da frequência cardíaca mostrou-se em bom nível, com alta sensibilidade e especificidade aceitável para os pontos de corte, conforme as diferentes análises estratificadas por sexo e estado nutricional. Desta forma, os profissionais de saúde poderão utilizar a frequência cardíaca para estimar o risco cardiovascular em crianças de diferentes sexos e estado nutricional. Objetivo (VFC Métodos 12 estudo 4 8 Antropometria estadiômetro disso ROC dados Resultados mostrouse (RMSSD 0,89 089 0 89 IC95 IC 0,77–1,00 077100 77 1 00 0,90 090 90 0,83–0,97. 083097 0,83–0,97 . 83 97 0,83–0,97) 9 10000 100 100,00 87,50%, 8750 87,50% , 87 50 87,50%) 9474 94 74 94,74 63,64%. 6364 63,64% 63 64 63,64%) frequênciaalta LF/HF LFHF LF HF (LF/HF prazodesvio prazo SD2/SD1. SD2SD1 SDSD SD2/SD1 SD2 SD1 SD (SD2/SD1) portanto casos Conclusões nível nutricional forma 0,8 08 IC9 0,77–1,0 07710 7 0,9 09 08309 0,83–0,9 1000 10 100,0 875 87,50 5 947 94,7 636 63,64 6 SD2SD SD2/SD (SD2/SD1 0, 0,77–1, 0771 0830 0,83–0, 100, 87,5 94, 63,6 (SD2/SD 0,77–1 077 083 0,83–0 87, 63, 0,77– 07 0,83– 0,77 0,83 0,7

ABSTRACT Objective: To evaluate the predictive validity and cut-off point of heart rate and blood pressure on heart rate variability (HRV) changes in children with and without obesity. Methods: This study included 125 children, of whom 41 were normal weight and 84 were obese. Anthropometry, blood pressure, heart rate, and HRV were measured using an electronic scale and stadiometer, a sphygmomanometer, and HRV monitor. In addition, the receiver operating characteristic (ROC) curve was obtained by statistical analysis of the data. Results: Heart rate proved to be a good predictor for changes in the square root of the mean of the square of the differences between consecutive NN intervals (RMSSD) parameter in students of both sexes for the normal-weight group (ROC 0.89; 95%CI 0.77–1.00) and obesity (ROC 0.90; 95%CI 0.83–0.97). In addition, the heart rate cut-off point for alterations in the RMSSD parameter for normal-weight boys was 93 bpm (sensitivity 100.00% and specificity 87.50%) and for boys with obesity, the established cut-off point was 91 bpm (sensitivity 94.74% and specificity 63.64%). Heart rate also proved to be a good predictor considering low-frequency/high-frequency ratio (LF/HF) and standard deviation of long-term continuous NN intervals /standard deviation of the instantaneous variability of continuous NN intervals in the Poincaré graph ratio (SD2/SD1). Systolic and diastolic blood pressures were good predictors in more specific stratifications and, therefore, can be used in some cases. Conclusions: The predictive validity of heart rate was shown to be at a good level, with high sensitivity and acceptable specificity for the cut-off points according to the different analyses stratified by gender and nutritional status. In this sense, health professionals will be able to use heart rate to estimate cardiovascular risk in children of different sexes and nutritional status. Objective cutoff cut off (HRV Methods 12 4 8 obese Anthropometry stadiometer sphygmomanometer monitor addition ROC data Results (RMSSD normalweight 0.89 089 0 89 95CI CI 95 0.77–1.00 077100 77 1 00 0.90 090 90 0.83–0.97. 083097 0.83–0.97 . 83 97 0.83–0.97) 9 10000 100 100.00 87.50% 8750 87 50 9474 94 74 94.74 63.64%. 6364 63.64% 63 64 63.64%) lowfrequency/highfrequency lowfrequencyhighfrequency low frequency/high frequency LF/HF LFHF LF HF (LF/HF longterm long term SD2/SD1. SD2SD1 SDSD SD2/SD1 SD2 SD1 SD (SD2/SD1) therefore cases Conclusions level status sense 0.8 08 0.77–1.0 07710 7 0.9 09 08309 0.83–0.9 1000 10 100.0 87.50 875 5 947 94.7 636 63.64 6 lowfrequency highfrequency frequencyhigh SD2SD SD2/SD (SD2/SD1 0. 0.77–1. 0771 0830 0.83–0. 100. 87.5 94. 63.6 (SD2/SD 0.77–1 077 083 0.83–0 87. 63. 0.77– 07 0.83– 0.77 0.83 0.7

Resumen Marco contextual: Las ambulancias de soporte vital inmediato (SVI) permiten al personal de enfermería intervenir en un contexto prehospitalario, con el apoyo de sus conocimientos técnico-científicos y de complejos protocolos de actuación y regulación médica a través de la telemedicina. Objetivo: Analizar las aportaciones de la intervención del personal de enfermería del SVI en la evolución del estado clínico de la persona en situación crítica (PSC). Metodología: Estudio cuantitativo, descriptivo-correlacional, retrospectivo, realizado en centros de SVI del norte de Portugal. Se analizaron 574 historias clínicas electrónicas entre el 1 de noviembre y el 31 de diciembre de 2019, correspondientes al mismo número de personas evaluadas. Se utilizó la escala National Early Warning Score (NEWS) para evaluar la evolución clínica de la PSC. Resultados: Se observó una evolución positiva en el score NEWS de la PSC, tras la intervención del personal de enfermería del SVI (M = 4,43 ± 3,901 vs 3,34 ± 3,329; sig < 0,001). Por el contrario, el riesgo clínico disminuyó significativamente tras la intervención del personal de enfermería. Conclusión: Se demostró la relevancia de la intervención del personal de enfermería del SVI en el contexto prehospitalario, como garantía de seguridad, calidad y mejora continua en la atención a la PSC.

Resumo Enquadramento: As ambulâncias de suporte imediato de vida (SIV) possibilitam ao enfermeiro capacidade de intervenção em contexto pré-hospitalar, suportada pelo seu conhecimento técnico-científico, protocolos complexos de atuação e regulação médica por telemedicina. Objetivo: Analisar os contributos da intervenção dos enfermeiros SIV, na evolução do estado clínico da pessoa em situação crítica (PSC). Metodologia: Estudo quantitativo, descritivo-correlacional, retrospetivo, realizado em meios SIV, na região norte de Portugal. Analisados 574 registos clínicos eletrónicos, entre 01 de novembro e 31 de dezembro de 2019, que correspondem ao mesmo número de pessoas avaliadas. Utilizada a escala National Early Warning Score (NEWS) para avaliar a evolução clínica da PSC. Resultados: Observou-se uma evolução positiva do score NEWS da PSC, após a intervenção do enfermeiro SIV (M = 4,43 ± 3,901 vs 3,34 ± 3,329; sig < 0,001). Em sentido inverso, o risco clínico diminuiu significativamente após a intervenção do enfermeiro. Conclusão: Demonstrou-se a relevância da intervenção do enfermeiro SIV no contexto pré-hospitalar, enquanto garantia de segurança, qualidade e melhoria contínua dos cuidados à PSC.

Abstract Background: Immediate life support (ILS) ambulances allow nurses to intervene in pre-hospital settings, supported by their technical-scientific knowledge and complex protocols of action and regulation through telemedicine. Objective: To analyze the contributions of nursing interventions in the evolution of the clinical state of critical patients. Methodology: Quantitative, descriptive-correlational, retrospective, and observational study conducted in ILS settings in northern Portugal. A total of 574 electronic clinical records were analyzed between 1 November and 31 December 2019, corresponding to the same number of people evaluated. The National Early Warning Score (NEWS) was used to assess the clinical evolution of critical patients. Results: There was a positive evolution of the NEWS score of critical patients after the intervention of ILS nurses (M = 4.43 ± 3.901 vs. 3.34 ± 3.329; sig < 0.001). Similarly, the clinical risk of critical patients decreased after the nurse’s intervention. Conclusion: This study demonstrated the importance of nurses in prehospital care, as a guarantee of safety, quality, and continuous improvement of care for critical patients.

Resumen Marco contextual: La ventilación no invasiva (VNI) es una estrategia terapéutica para las personas con insuficiencia respiratoria aguda (IRA). Objetivo: Analizar la relación entre las variables sociodemográficas y clínicas de las personas ingresadas en medicina interna y la adaptación y complicaciones de la VNI. Metodología: Estudio observacional retrospectivo de cohortes con una muestra de 239 personas. Los datos se recogieron a través de registros electrónicos en SClínico, mediante una guía de extracción de datos. Resultados: Se observó que el 25,1% de las personas no eran aptas para la VNI, lo que se asoció significativamente con la alimentación oral, la confusión y el uso de contención mecánica. Se produjeron complicaciones en el 33,5% de la muestra, y las más frecuentes fueron secreciones, lesiones en la nariz y vómitos. Se encontró una asociación estadísticamente significativa entre el número de complicaciones y las personas alimentadas por sonda nasogástrica (SNG), confusas, con medidas de contención mecánica y que utilizaban mascarilla oronasal. Conclusión: La persona sometida a VNI debe ser controlada por un equipo de enfermería especializado. Deben aplicarse protocolos para prevenir complicaciones y favorecer la adaptabilidad a la VNI.

Resumo Enquadramento: A ventilação não invasiva (VNI) constitui uma estratégia terapêutica à pessoa com insuficiência respiratória aguda (IRA). Objetivo: Analisar a relação entre as variáveis sociodemográficas e clínicas, das pessoas internadas na medicina interna, e a adaptação e complicações da VNI. Metodologia: Estudo observacional retrospetivo de coorte, com amostra de 239 pessoas. A colheita de dados foi efetuada através de registos eletrónicos no SClínico, utilizando um guia de extração de dados. Resultados: Verificou-se que 25,1% das pessoas estavam inadaptadas à VNI, associando-se significativamente com a alimentação oral, confusão e uso de contenção mecânica. As complicações verificaram-se em 33,5% da amostra, sendo as mais frequentes secreções, lesão no nariz e vómitos. Constatou-se uma associação estatisticamente significativa entre o número de complicações e pessoas alimentadas por sonda nasogástrica (SNG), confusas, com medidas de contenção mecânica e a utilizarem máscara oro-nasal. Conclusão: A vigilância da pessoa submetida a VNI deve ser assegurada por uma equipa de enfermagem especializada. Devem ser implementados protocolos conducentes à prevenção de complicações e promotores de adaptabilidade à VNI.

Abstract Background: Non-invasive ventilation is a therapeutic strategy for patients with acute respiratory failure. Objective: To analyze the relationship between the sociodemographic and clinical variables of patients hospitalized in internal medicine services and the adaptation to and complications of non-invasive ventilation. Methodology: A retrospective observational cohort study was carried out with a sample of 239 patients. Data were collected from electronic records in the information system SClínico, using a data extraction guide. Results: A total of 25.1% of the participants did not adapt to non-invasive ventilation, and this was significantly associated with oral feeding, confusion, and the use of mechanical restraint measures. Complications occurred in 33.5% of the sample. The most frequent complications were secretions, nasal injuries, and vomiting. There was a statistically significant association between the number of complications and patients fed by nasogastric tube, confused, with mechanical restraint measures, and wearing an oronasal mask. Conclusion: The monitoring of patients on non-invasive ventilation should be carried out by a specialized nursing team. Protocols should be implemented to prevent complications and promote patient adaptation to non-invasive ventilation.

ABSTRACT Paracoccidioidomycosis (PCM) is a systemic disease endemic to Latin American countries, with a high impact in terms of morbidity, mortality and costs for the health system if patients progress to advanced stages. This work aimed to collect data published in publications on autochthonous cases of PCM, from the first cases diagnosed in Paraguay, with a description of the historical context and identifying the pioneers in the diagnosis in Paraguay, following a chronological order, to the most recently reported cases. Methodology: search in national libraries and online databases of PCM cases in Paraguay, published in national historical scientific journals and other sources available in print format, and more recent scientific articles available in electronic format, respectively. Results: 479 cases of PCM were identified in publications between the years 1935 and 2023, corresponding to autochthonous cases and whose diagnoses were made in Paraguayan territory. Dr. Juan Boggino and collaborators were responsible for the first diagnoses in the country. The predominant clinical form was chronic. The average age was 45.78 years. The vast majority of patients diagnosed were from the Eastern Region of the country, predominantly male farmers. Conclusion: PCM is an endemic disease in Paraguay. Since the first cases were diagnosed and until today, patients with a severe and disabling course of the disease have been detected, which demonstrates the need to disseminate its knowledge and expand the early diagnostic capacity at the national level. Due to its clinical pleomorphism and its ability to simulate other diseases, it is important to include PCM as a differential diagnosis for patients who present risk factors for the development of the disease.

RESUMEN La Paracoccidioidomicosis (PCM), es una enfermedad sistémica endémica de países de América Latina, con alto impacto en términos de morbilidad, mortalidad y costos para el sistema de salud si los enfermos progresan a sus estadios avanzados. Este trabajo tuvo como objetivo recopilar datos divulgados en publicaciones sobre casos autóctonos de PCM, desde los primeros casos diagnosticados en Paraguay, con una descripción del contexto histórico e identificando a los pioneros en el diagnóstico en Paraguay, siguiendo un orden cronológico, hasta los casos más recientemente informados. Metodología: búsqueda en bibliotecas nacionales y bases de datos online de casos de PCM en Paraguay, publicados en revistas científicas históricas nacionales y otras fuentes disponibles en formato impreso, y artículos científicos más recientes disponibles en formato electrónico, respectivamente. Resultados: Se identificaron 479 casos de PCM en publicaciones entre los años 1935 y 2023, correspondientes a casos autóctonos y cuyos diagnósticos fueron realizados en territorio paraguayo. El Dr. Juan Boggino y colaboradores fueron los responsables de los primeros diagnósticos en el país. La forma clínica predominante fue la crónica. La media de edad de 45,78 años. La gran mayoría de los pacientes diagnosticados fueron oriundos de la Región Oriental del país, predominantemente hombres agricultores. Conclusión: La PCM es una enfermedad endémica del Paraguay, desde los primeros casos diagnosticados y hasta hoy en día, son detectados pacientes con una evolución grave y discapacitante de la enfermedad, lo que demuestra la necesidad de la difusión de su conocimiento y ampliación de la capacidad diagnóstica precoz a nivel nacional. Debido a su pleomorfismo clínico y su capacidad de simular otras enfermedades, es importante incluir a la PCM como diagnóstico diferencial de pacientes que presenten factores de riesgo para el desarrollo de la enfermedad.

ABSTRACT Introduction: Leprosy (Hansen's disease) is a neglected infectious disease that affects skin and peripheral nerves, triggering neuropathies and complications such as deformities and disabilities. Objective: determine epidemiological and clinical characteristics of patients with Leprosy in the Dermatological Specialties Center of the Ministry of Public Health and Social Welfare of Paraguay, from January 2021 to December 2022. Methodology: descriptive, observational, retrospective, cross-sectional study. Data management and analysis was carried out in an electronic spreadsheet (Excel from Microsoft Office 365 version 2405), then descriptive statistics were performed. Results: 123 cases of leprosy were diagnosed, 45 (36.58 %) were women and 78 (63.42 %) were men; the ages were between 17 and 86 years, the most affected range was 41 to 50 years. 112 cases (91.06 %) were multibacillary leprosy. The most frequent sign was infiltrated plaque, present in 88 cases (71.54 %). 58 patients (47.15 %) presented lepromatous reactions, 31 cases of type 1 (53.45 %). 34 cases (27.64 %) presented grade 1 disability and 10 cases (8.13 %) grade 2 disability. Conclusion: The profile of the patient with leprosy was male between 41 and 50 years, the majority being multibacillary cases. Early diagnosis and adequate treatment are essential to reduce the burden of the disease and disabilities.

RESUMEN Introducción: lepra (enfermedad de Hansen) es una patología infecciosa desatendida que afecta piel y nervios periféricos, desencadenando neuropatías y complicaciones como deformidades y discapacidades. Objetivos: determinar características epidemiológicas y clínicas de pacientes con lepra en el Centro de Especialidades Dermatológicas del Ministerio de Salud Pública y Bienestar Social de Paraguay, de enero 2021 a diciembre 2022. Metodología: estudio descriptivo, observacional, retrospectivo, de corte transversal. La gestión y análisis de datos se realizó en planilla electrónica (Excel del programa Microsoft Office 365 versión 2405), luego se realizó estadística descriptiva. Resultados: se diagnosticaron 123 casos de lepra, 45 (36,58 %) eran mujeres y 78 (63,42 %) varones; las edades estaban entre 17 y 86 años, el rango más afectado fue de 41 a 50 años. Eran lepra multibacilar 112 casos (91,06%). El signo más frecuente fue la placa infiltrada, presentada en 88 casos (71,54%). 58 pacientes (47,15%) presentaron reacciones lepromatosas, siendo, 31 casos de tipo 1 (53,45 %). 34 casos (27,64%) presentaron discapacidad grado 1 y 10 casos (8,13%) discapacidad grado 2. Conclusión: el perfil del paciente con lepra fue del sexo masculino entre 41 a 50 años, siendo la mayoría casos multibacilares. Es fundamentales el diagnóstico precoz y el tratamiento adecuado para reducir la carga de la enfermedad y las discapacidades.

Abstract This study aims to analyse the influence of the operation mode and demographic and anthropometric variables on the self-assessed productivity of users of mixed-mode and fully air-conditioned buildings in Florianópolis, southern Brazil. Demographic and anthropometric data were collected using electronic questionnaires made available to users. A total of 1,247 responses were recorded. The influence of the mode of operation on productivity was analysed using histograms. A predictive model was developed by means of linear and quadratic regressions to identify the environmental and demographic/anthropometric parameters influencing productivity. It was observed no influence of hybrid buildings or those with central air-conditioning systems on the perception of productivity. Although the predictive model did not show a good ability to explain users’ performance, it showed statistical correlations between productivity and operative temperature, gender and age. It was concluded that office users’ perception of productivity is affected by the configuration of environments in the humid subtropical climate of Florianópolis. selfassessed self assessed mixedmode mixed airconditioned air conditioned Florianópolis Brazil 1247 1 247 1,24 recorded histograms demographicanthropometric airconditioning conditioning performance temperature age 124 24 1,2 12 2 1,

Resumo O objetivo deste estudo é analisar a influência do modo de operação e de variáveis demográficas e antropométricas na produtividade autoavaliada de usuários de edificações de escritório com sistema de ventilação híbrido e central, em Florianópolis - SC. Os dados demográficos e antropométricos foram coletados por meio de questionários eletrônicos. A influência do modo de operação na produtividade foi analisada por meio de histogramas. Um modelo preditivo foi desenvolvido por meio de regressões lineares e quadráticas para identificar os parâmetros ambientais e demográficos/antropométricos que exercem influência na produtividade. Os resultados mostraram que não houve distinção da influência exercida por edificações híbridas ou com sistema de ar-condicionado central na percepção da produtividade. Apesar de o modelo preditivo não ter apresentado boa capacidade de explicar o desempenho dos usuários, evidenciou correlações estatísticas entre produtividade e temperatura operativa, gênero e idade. Concluiu-se que a percepção de produtividade dos usuários de escritórios é afetada pela configuração dos ambientes no clima subtropical úmido de Florianópolis. SC eletrônicos histogramas demográficosantropométricos arcondicionado ar condicionado operativa idade Concluiuse Concluiu se

RESUMEN El comercio electrónico se ha convertido en una actividad global practicada por un número cada vez más creciente de personas que interactúan en el mercado de bienes y servicios. El objetivo de este estudio fue identificar y analizar las costumbres y hábitos de compras de los consumidores de Asunción y del Departamento Central de Paraguay en relación a las compras en línea. Se utilizó un enfoque cuali-cuantitativo y se aplicó una encuesta en formato electrónico a un total de 400 participantes residentes en las zonas de influencia del estudio. Se observo que gran parte de la población analizada utiliza este método de compras y qué lo hacen de manera frecuente, aunque con una clara preferencia por ciertos tipos de productos como es el caso de los alimentos, que mayormente son adquiridos vía servicios de delivery desde tiendas locales; y también los pedidos de ropas, que generalmente son adquiridos desde tiendas internacionales, aunque también provienen en un número importante de tiendas locales que ofrecen sus productos principalmente a través de redes sociales. Los resultados más relevantes señalan que la mayoría de los participantes ya realizan compras en línea y que estarían dispuestos a repetir las compras en esa modalidad, debido a que las experiencias en general han sido positivas. Como recomendación, se expresa que las empresas locales deberían invertir mayores recursos para dotar a sus negocios de un sistema de comercio electrónico que les permita concretar transacciones en línea incluyendo el proceso de cobros con distintos medios de pago.

ABSTRACT E-commerce has become a global activity practiced by an increasing number of people who interact in the market for goods and services. The objective of this study was to identify and analyze the customs and shopping habits of consumers in Asunción and the Central Department of Paraguay in relation to online shopping. A quantitative approach was used and a survey in electronic format was applied to a total of 400 participants residing in the areas of influence of the study. It was observed that a large part of the population analyzed uses this shopping method and that they do so frequently, although with a clear preference for certain types of products such as food, which are mostly purchased via delivery services from local stores; and also clothing orders, which are generally purchased from international stores, although they also come in a significant number from local stores that offer their products mainly through social networks. The most relevant results indicate that most of the participants already make purchases online and that they would be willing to repeat purchases in this modality, since the experiences have generally been positive. As a recommendation, it is expressed that local companies should invest more resources to provide their businesses with an e-commerce system that allows them to carry out online transactions, including the collection process with different means of payment.

Resumen Hasta 2017, solo uno de dieciocho ministerios en Perú publicó información completa en el Portal de Transparencia Estándar, conforme a lo estipulado por la Ley de Transparencia. Este artículo ofrece un diagnóstico de la evolución de ese resultado para el período 2018-2020 y registra un ligero incremento. Dos herramientas proveyeron datos: la aplicación de una tabla de indicadores de forma y contenido a la información publicada por los ministerios en sus portales y la cuantificación de esos resultados con un programa estadístico. Tres ministerios publican información completa y alcanzaron el puntaje máximo, mientras que quince de ellos no logran implementar lo estipulado en la normativa. No obstante y en conclusión, existen avances respecto al cumplimiento de la ley debido al volumen y características de datos publicados.

Abstract Until 2017, only one out of eighteen ministries in Peru published complete information on the Standard Transparency Portal, as stipulated by the Transparency Law. This article provides a diagnosis of the evolution of that result for the period 2018-2020 and records a slight increase. Two tools provided data: applying a table of indicators of form and content to the information published by ministries on their portals and assessing these results with a statistical programme. Three ministries published complete information and reached the maximum score, while fifteen failed to comply with the law. Nevertheless, there is progress concerning compliance with the law due to the volume and characteristics of published data.

Abstract: The use of e-commerce to enhance consumer relationships is becoming increasingly important in the information society. The constant development of technologies allows existing platforms to benefit from their characteristics; however, these advancements also bring various legal issues that must be addressed to protect users' interests and rights. Blockchain technology is revolutionizing B2C electronic relations due to its transnational nature, decentralization, guarantee of trust, immutability, and one of its most distinctive functionalities: smart contracts. These agreements are characterized by their automation and self-execution, features that can conflict with existing consumer and user legislation. Additionally, the opportunities provided by Blockchain, such as allowing users to act anonymously, may contradict regulations concerning the determination of international judicial jurisdiction and the applicable law for B2C consumer legal relationships. This work aims to analyze the applicability of smart contracts in e-commerce, particularly for B2C companies, and to study the potential issues they pose for current regulations, in order to determine whether these regulations need to be adapted for these technologies

Resumen: El uso del comercio electrónico para celebrar relaciones de consumo cada vez toma más protagonismo en la sociedad de la información. El constante desarrollo de las tecnologías hace que las plataformas existentes puedan beneficiarse de sus características; sin embargo, también traen consigo diferentes cuestiones jurídicas que deben mitigarse a fin de proteger los intereses y derechos de los usuarios. La tecnología blockchain es una de las tecnologías que viene a revolucionar el ámbito de las relaciones electrónicas B2C gracias a su carácter transnacional, descentralización, garantía de confianza, inmutabilidad y a una de sus funcionalidades más características: los smart contracts. Este tipo de acuerdos se distinguen por su automatización y autoejecución, caracteres que a priori pueden poner en riesgo la legislación existente sobre consumidores y usuarios. Asimismo, las oportunidades que brinda blockchain de cara a que los usuarios puedan actuar de forma irreconocible puede poner en jaque la normativa encargada de determinar la competencia judicial internacional y la ley aplicable a las relaciones jurídicas de consumo B2C. Este trabajo analiza la aplicabilidad de los smart contracts en el ámbito del comercio electrónico, en especial en el de empresas con consumidores (B2C) y estudiar los posibles inconvenientes que generan sobre la normativa existente a fin de analizar si es necesario adaptar la legislación a estas tecnologías

Resumo: A utilização do comércio eletrônico para efetivar relações de consumo assume cada vez mais um papel central na sociedade da informação. O constante desenvolvimento das tecnologias faz com que as plataformas existentes possam beneficiar-se das suas características, no entanto, também trazem consigo diversas questões jurídicas que devem ser mitigadas de forma a proteger os interesses e direitos dos usuários. A tecnologia blockchain é uma das tecnologias que veio revolucionar o campo das relações eletrônicas B2C graças ao seu carácter transnacional, descentralização, garantia de confiança, imutabilidade e uma das suas funcionalidades mais características, os smart contracts. Estes tipos de acordos distinguem-se pela sua automatização e auto-execução, características que, a priori, podem colocar em risco a legislação existente sobre consumidores e usuários. Da mesma forma, as oportunidades que o Blockchain oferece para que os usuários possam agir de forma irreconhecível podem colocar em xeque os regulamentos encarregados de determinar a competência judicial internacional e a lei aplicável às relações jurídicas de consumo B2C. O objetivo deste trabalho é analisar a aplicabilidade dos smart contracts no campo do comércio eletrônico, especialmente o de empresas com consumidores (B2C) e estudar os possíveis inconvenientes que eles geram sobre a regulamentação existente, a fim de analisar se é necessário adaptar a legislação a estas tecnologias