The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stands for being the most serious epidemic (so far) of the 21st century. However, only a few computational studies have investigated the molecular mechanisms underlying the neutralization of the spike protein by antibodies of different classes. Hence, bioinformatic methods were employed to unravel the factors contributing to the remarkable neutralization capacity exhibited by specific antibodies. Initially, crystallographic structures of IgA monomeric / dimeric, IgG, and IgM antibodies binding with the receptor-binding domain region of the SARS-CoV-2 spike protein were retrieved. Subsequently, rigid molecular docking and molecular dynamic simulations were performed over 100 ns with explicit water solvation. Lastly, an energy decomposition was conducted to estimate the binding affinity using the last frames from molecular dynamics. The results revealed a higher binding affinity for both monomeric and dimeric forms of IgA antibodies against the spike protein. Additionally, a greater number of hydrogen bonds were observed during their interaction with the spike protein, as well as greater structural instability along the time and especially a more thermodynamically favorable interaction affinity. In this way, the research contributes a small piece to the complex puzzle of understanding the humoral immune response induced by the SARS-CoV-2 virus. SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 so far st century However classes Hence Initially IgG receptorbinding receptor SARS-CoV- retrieved Subsequently 10 solvation Lastly dynamics Additionally way virus (SARS-CoV- SARS-CoV 1 (SARS-CoV

Computational predictive approaches present themselves as an attractive alternative in the search for new compounds that may present toxic or growth regulatory activity in Aedes aegypti. Aspergillus species is a producer of secondary metabolites with diverse biological activities. In this study, it was possible to evaluate the pharmacokinetic and toxicological properties in silico, as well as the prediction of the insecticidal biological activities of the juvenile hormone of natural substances produced by the genus Aspergillus. Initially, 187 molecules were cataloged from various species of Aspergillus spp., and only seven molecules of indole alkaloids were found to exhibit a toxic dose 50% (TD50) after conducting toxicity predictions. The molecular dynamic simulation trajectories were utilized to study parameters such as root mean square deviation, root mean square fluctuation, radius of gyration and intermolecular hydrogen bond to understand the behavior and stability of proposed compounds in the binding pocket of the target protein. The N-β-acetyltryptamine molecule showed a binding affinity value of –8.100 ± 0.200 kcal mol-1, which classifies the compound as a potential insecticidal agent against the Aedes aegypti vector. silico Initially 18 spp spp. 50 TD50 TD (TD50 predictions deviation fluctuation protein Nβacetyltryptamine N β acetyltryptamine 8100 8 100 –8.10 0200 0 200 0.20 mol1, mol1 mol 1, 1 mol-1 vector 5 TD5 (TD5 810 10 –8.1 020 20 0.2 mol- (TD 81 –8. 02 2 0. –8 –

RESUMEN El propósito de la investigación es examinar los sistemas de planificación y sus mecanismos regulatorios para entender cómo se organizan y regulan, ya sea parcial o completamente, dependiendo de la organización para lograr la consecución de objetivos. Las aportaciones teóricas de la investigación se centran en la conceptualización de la teoría de sistemas. El aporte metodológico se basa en el desarrollo de un esquema secuencial y lógico con la aplicación de un dendrograma de variables, que permite eliminar superposiciones entre el conjunto de conceptos analizados. Las conclusiones de la investigación permiten comprobar que las organizaciones son entidades dinámicas y cambiantes que se ven inevitablemente impactadas por el entorno en el que operan; además las instituciones funcionan sinérgicamente desde puntos de vista interrelacionados e interdependientes.

ABSTRACT The purpose of the research is to examine planning systems and their regulatory mechanisms to understand how they are organized and regulated, either partially or completely, depending on the organization to achieve the attainment of objectives. The theoretical contributions of the research are centered on the conceptualization of systems theory. The methodological contribution is based on the development of a sequential and logical scheme with the application of a dendrogram of variables, which allows eliminating overlaps between the set of concepts analyzed. The conclusions of the research show that organizations are dynamic and changing entities that are inevitably impacted by the environment in which they operate; in addition, institutions function synergistically from interrelated and interdependent points of view.

RESUMEN En la actualidad las organizaciones deben hacer frente a numerosos riesgos, dada la multitud de actividades que se desarrollan diariamente en un entorno dinámico e incierto, por lo que se hace necesario perfeccionar los modelos de gestión en función de lograr mejoras en su desempeño organizacional. El objetivo de la propuesta que se presenta es una metodología para la gestión de riesgo basado en las normas ISO 31000 en una entidad de ciencia, tecnología e innovación. Se emplearon varios métodos y técnicas que permitieron transitar desde el análisis de los fundamentos teóricos y conceptuales que permitieron presentar la metodológica, emergiendo como un instrumento para coordinar y realizar las acciones necesarias para reducir vulnerabilidades para prevenir, mitigar, atender y recuperar efectos negativos.

ABSTRACT Currently, organizations must face numerous risks, given the multitude of activities that are carried out daily in a dynamic and uncertain environment, which makes it necessary to improve management models in order to achieve improvements in their organizational performance. The objective of the proposal presented is a risk management methodology based on ISO 31000 standards in a science, technology and innovation entity. Several methods and techniques were used that allowed to move from the analysis of the theoretical and conceptual foundations that allowed to present the methodology, emerging as an instrument to coordinate and carry out the necessary actions to reduce vulnerabilities to prevent, mitigate, attend and recover negative effects.

Resumen (Objetivo) Plasmodium vivax infecta ampliamente a muchas personas en algunas regiones. La singularidad de formar una etapa latente hace que la malaria vivax pueda ser inducida por una recaída por una infección adicional. En el presente estudio, utilizamos un enfoque de simulación dinámica y acoplamiento molecular ara predecir la posibilidad de que compuestos bioactivos de la familia de plantas Zingiberaceae sean candidatos a fármaco contra la malaria dirigiéndose a la proteína de unión a Duffy de Plasmodium vivax (PvDBP). Se requiere la interacción molecular PvDBP-DARC para mediar el proceso de invasión de merozoitos en los glóbulos rojos. La inhibición de este proceso posiblemente pueda controlar el crecimiento y desarrollo del parásito. (Metodología) El análisis de acoplamiento molecular dio como resultado los dos compuestos principales con el valor de energía de unión más bajo, incluida la 5,7-dihidroxiflavanona (-9,3 kcal/mol) y la pinostrobina (-9,2 kcal/mol). (Resultados) Estos compuestos previstos tienen una interacción más fuerte que la cloroquina como control. Además, los compue potenciales también interactúan con los residuos del sitio de unión de DARC y lo mantienen durante el proceso de simulación de dinámica molecular. De lo contrario, la cloroquina como control no puede retener el 75% de los residuos de unión hacia PvDBP. El estudio de dinámica molecular reveló que los tres complejos tienen una estabilidad relativamente similar. (Conclusiones) Predijimos que los dos compuestos bioactivos tienen potencial como inhibidores de la invasión de merozoitos.

Resumo (Objetivo) O Plasmodium vivax infecta amplamente muitas pessoas em algumas regiões. A singularidade de formar um estágio latente significa que a malária vivax pode ser induzida por recaída devido à infecção adicional. No presente estudo, utilizamos uma abordagem de simulação dinâmica e de acoplamento molecular para prever a possibilidade de compostos bioativos da família de plantas Zingiberaceae como candidatos a medicamentos antimaláricos, visand o aproteína de ligação Duffy do Plasmodium vivax (PvDBP). A interação molecular PvDBP-DARC é necessária para mediar o processo de invasão de merozoítos nos glóbulos vermelhos. A inibição deste processo pode possivelmente controlar o crescimento e desenvolvimento do parasita. (Metodologia) A análise de acoplamento molecular resultou nos dois principais compostos com o menor valor de energia de ligação, incluindo ,7-dihidroxiflavanona (-9,3 kcal/mol) e pinostrobina (-9,2 kcal/mol). (Resultados) Esses compostos previstos têm uma interação mais forte do que a cloroquina como controle. Além disso, os compostos potenciais também interagem e mantêm resíduos do sítio de ligação do DARC durante o processo de simulação de dinâmica molecular. Caso contrário, a cloroquina como controle não pode reter 75% dos resíduos de ligação ao três complexos apresentam estabilidade relativa compostos bioativos têm potencial como inibidor Palavras chave: Medicamentos antimalária; ePvmeesdmsilDBP. ntesa invício;O estudo de dinâmica molecular revelou que os emelhante. (Conclusões) Previmos que os dois asão de merozoítos. Plasmodium vivax; PvDBP; Zingiberáceas.

Abstract (Objective) Plasmodium vivax predominantly infects many people in numerous tropical areas, including Southeast Asia, the Western Pacific, the Americas, and the Eastern Mediterranean. The uniqueness of forming dormant stages can lead to relapse in vivax malaria upon further infection. This study used molecular docking and dynamic simulation to predict potential bioactive compounds from the Zingiberaceae plant family as inhibitors by targeting Plasmodium vivax Duffy Binding Protein (PvDBP). PvDBP-DARC molecular interaction is required to mediate the merozoite invasion process into red blood cells. Inhibiting this process can possibly control parasite growth and development. (Methodology) Molecular docking screening was conducted by using 138 natural compounds from the Zingiberaceae plant family targeting Plasmodium vivax Duffy binding protein (PvDBP). The top two compounds with the lowest binding energy were selected to be analyzed by pharmacokinetics prediction and molecular dynamic (MD) simulation. (Results) Molecular docking screening resulted in the top two compounds with the lowest binding energy value, including 5,7-dihydroxyflavanone (-9.3 kcal/mol) and pinostrobin (-9.2 kcal/mol). These compounds are predicted to have stronger interaction than chloroquine as a control. Furthermore, the potential compounds also interact with DARC binding site residues and maintain them during the molecular dynamic simulation process. Otherwise, chloroquine as a control cannot retain 75% binding residues towards PvDBP. A molecular dynamic study revealed that all three complexes have relatively similar stability. (Conclusions) We predicted that the two bioactive compounds (5,7-dihydroxyflavanone and pinostrobin) have the potential as merozoite invasion inhibitors.

Abstract: This paper presents a methodology, based on frequency response models, to estimate the minimum or maximum value -nadir- that the frequency reaches when a generation - load unbalance occurs in the power system. To this end, the 1st order reduced equivalent model of the generator’s power-frequency control system is determined using the "Parameter Estimator" of Matlab/Simulink. Then, a set of equations coming from the reduced equivalent model is established to estimate the value of the maximum transient frequency deviation and its occurrence time. To illustrate the application of the proposed methodology, the IEEE New England test system has been chosen. Once this is done, the proposed methodology is applied to the Ecuadorian Interconnected Power System. The results of time domain simulations using the PowerFactory software are presented and compared with the results calculated using the developed reduced and analytical models. It is concluded that the proposed methodology estimates with high accuracy the maximum transient frequency deviation and its time of occurrence.

Resumen: En el presente trabajo se presenta una metodología, basada en modelos de repuesta de la frecuencia, para estimar el valor mínimo o máximo -nadir- que alcanza la frecuencia cuando en el sistema eléctrico de potencia se presenta un desbalance generación - carga. Con este fin, se determina el modelo reducido de 1er orden del sistema de control potencia - frecuencia del generador usando el “Estimador de Parámetros” de Matlab/Simulink. Luego, se establecen ecuaciones que provienen del modelo equivalente reducido para estimar el valor de la máxima desviación transitoria de la frecuencia y su tiempo de ocurrencia. Para ilustrar la aplicación de la metodología presentada se ha elegido el sistema de prueba IEEE New England de 39 barras y 10 generadores. Hecho esto, la metodología propuesta se aplica al Sistema Nacional Interconectado ecuatoriano. Se presentan resultados de simulaciones en el dominio del tiempo usando el programa PowerFactory, mismos que son comparados con los resultados calculados mediante el modelo equivalente reducido y el modelo analítico. Se concluye que la metodología propuesta estima con alta precisión la máxima desviación transitoria de la frecuencia y su tiempo de ocurrencia.

ABSTRACT Why is the prison crisis in Ecuador not solved? is the question that leads us to explore the penitentiary problem from its origins to the current Ecuadorian context. The objective is to reflect and demonstrate that prisons and deprivation of liberty have maintained the same dynamic since their origins, causing suffering and pain to inmates, in contrast to the resocializing purpose of punishment; The current context shows that prison management has not evolved, despite the scientific and regulatory development of this branch. The qualitative and socio-legal approach is the basis of the research because through the narrative design the history of the penitentiary system, the regulatory advance, and are compared with social reality are sequentially described; That is, an approach to the right to society is made through the documentary review of secondary sources. In short, it is concluded that there is no political will of the State to address the problem technically and with specialized personnel as suggested by the doctrine; on the contrary, the prison crisis in Ecuador has an anachronistic, dehumanizing tone and is far from the purpose of the sorrow; That is, there is no rehabilitation or resocialization.

RESUMEN ¿Por qué no se soluciona la crisis carcelaria en Ecuador? Esta pregunta lleva a explorar la problemática penitenciaria desde sus orígenes hasta llegar al contexto ecuatoriano actual. El objetivo es reflexionar y demostrar que las prisiones y la privación de libertad han mantenido la misma dinámica desde sus orígenes, causando sufrimiento y dolor a los reclusos, en contraposición a la finalidad resocializadora de la pena; el contexto actual demuestra que la gestión penitenciaria no ha evolucionado, pese al desarrollo científico y normativo de esta rama. El enfoque cualitativo y socio-jurídico son la base de la investigación porque a través del diseño narrativo se describe de forma secuencial la historia del sistema penitenciario, el avance normativo y se compara con la realidad social; es decir, se hace un acercamiento del derecho a la sociedad a través de la revisión documental de fuentes secundarias. En definitiva, se concluye que no existe la voluntad política del Estado para abordar el problema de forma técnica y con el personal especializado, tal como sugiere la doctrina; al contrario, la crisis carcelaria en Ecuador tiene un tinte anacrónico, deshumanizante y alejado de la finalidad de la pena; es decir, no hay rehabilitación ni resocialización.

RESUMO Desde 1965, os Programas de Pós-Graduação no Brasil têm aplicado exames de proficiência com o objetivo de verificar a capacidade de leitura, interpretação e compreensão de textos em línguas estrangeiras. Nesses exames, a única fonte de pesquisa permitida é o dicionário impresso. Guiado pela teoria dos Sistemas Dinâmicos Complexos, este artigo propõe uma reflexão sobre a relevância desse modelo de exame, no contexto das práticas sociais mediadas por tecnologias digitais que, devido à pandemia da COVID-19, tiveram que se adaptar. A análise foi baseada em 93 editais publicados pelos Programas antes da pandemia (2017-2019) e durante a pandemia (2020-2021). Os resultados mostram que apenas o CEFET-MG, durante a pandemia, propôs um exame em que todas as fontes (analógicas e digitais) foram permitidas aos candidatos. 1965 PósGraduação Pós Graduação leitura estrangeiras impresso Complexos COVID19, COVID19 COVID 19, 19 COVID-19 adaptar 9 20172019 2017 2019 (2017-2019 20202021. 20202021 2020 2021 . (2020-2021) CEFETMG, CEFETMG CEFET MG, MG CEFET-MG analógicas candidatos 196 COVID1 1 COVID-1 2017201 201 (2017-201 2020202 202 (2020-2021 COVID- 201720 20 (2017-20 202020 (2020-202 20172 2 (2017-2 20202 (2020-20 (2017- (2020-2 (2017 (2020- (201 (2020 (20 (202 (2 (

ABSTRACT Since 1965, graduate Programs in Brazil, with the objective to verify the capacity to read, interpret and understand texts in foreign languages, have applied proficiency exams, in which the only research source allowed is the printed dictionary. Guided by the theory of Complex Dynamic Systems, this article proposes a reflection on the relevance of this examination model, in the context of social practices mediated by digital technologies that, due to the COVID-19 pandemic, had to adapt. The analysis was based on 93 public notices published by the Programs before the pandemic (2017-2019) and during the pandemic (2020-2021). The results show that only CEFET-MG, during the Covid-19 pandemic, proposed an exam in which all sources (analogic and digital) were allowed to candidates. 1965 Brazil read languages exams dictionary Systems model COVID19 COVID 19 COVID-1 adapt 9 20172019 2017 2019 (2017-2019 20202021. 20202021 2020 2021 . (2020-2021) CEFETMG, CEFETMG CEFET MG, MG CEFET-MG Covid19 Covid Covid-1 analogic candidates 196 COVID1 1 COVID- 2017201 201 (2017-201 2020202 202 (2020-2021 Covid1 Covid- 201720 20 (2017-20 202020 (2020-202 20172 2 (2017-2 20202 (2020-20 (2017- (2020-2 (2017 (2020- (201 (2020 (20 (202 (2 (

ABSTRACT In the MAS Holding Boxing Club, in Sri Lanka, there are insufficiencies in the relationships between the organizational areas of the current structure and with it, little coherence of strategic actions to achieve the objectives of the sports institution; this is manifested in the poor stability of competitive results nationally and internationally, the above, associated with the fact that the organizational structure responds to very pragmatic and utilitarian criteria, is insufficient and has become a barrier that prevents creatively assuming the changes in the environment. The research aims to determine the components of a structure for the sports management of the MAS Holding Boxing Club, Sri Lanka. The result is in the theoretical conception of the organizational structure for the Mas Holding Boxing Club that responds to the legal, political and administrative foundations of the country, and responds to the demands for changes for the development of sporting activity. This structure is supported by principles such as efficiency, dynamic, flexible and innovative character and subject to change, depending on the scenarios presented to boxing.

RESUMO No MAS Holding Boxing Club, Sri Lanka, existem insuficiências nas relações entre as áreas organizacionais da estrutura atual e, com isso, pouca coerência de ações estratégicas para a consecução dos objetivos da instituição esportiva; isso se manifesta na pouca estabilidade dos resultados competitivos nacionais e internacionais, isso associado ao fato de que a estrutura organizacional responde a critérios muito pragmáticos e utilitários, é insuficiente e se tornou uma barreira que a impede de assumir, criativamente, as mudanças do ambiente. A pesquisa tem como objetivo determinar os componentes de uma estrutura para a gestão esportiva do MAS Holding Boxing Club, Sri Lanka. O resultado é a concepção teórica da estrutura organizacional do Mas Holding Boxing Club que atende aos fundamentos legais, políticos e administrativos do país e responde às demandas de mudança para o desenvolvimento da atividade esportiva. Essa estrutura se baseia em princípios como eficiência, caráter dinâmico, flexível e inovador e está sujeita a mudanças, de acordo com os cenários que surgem no boxe.

RESUMEN En el Club de Boxeo MAS Holding, en Sri Lanka, se constatan insuficiencias en las relaciones entre las áreas organizativas de la estructura actual y con ello, poca coherencia de acciones estratégicas para el logro de los objetivos de la institución deportiva; ello se manifiesta en la poca estabilidad de los resultados competitivos nacional e internacionalmente, lo anterior asociado a que la estructura organizativa responde a criterios muy pragmáticos y utilitarios, resulta insuficiente y se ha convertido en una barrera que impide asumir, creadoramente, los cambios del entorno. La investigación tiene como objetivo determinar los componentes de una estructura para la gestión deportiva del Club de Boxeo MAS Holding, Sri Lanka. El resultado está en la concepción teórica de la estructura organizacional para el Club de Boxeo Mas Holding que responde a los fundamentos jurídicos, políticos y administrativos del país, y da respuesta a las exigencias de cambios para el desarrollo de la actividad deportiva. Se sostiene dicha estructura en principios como la eficiencia, el carácter dinámico, flexible e innovador y sujeta a cambios, según los escenarios que se presenten al boxeo.

Abstract Social networks have become an ideal space for the exchange of information and knowledge. The objetive of this study was to determine the usefulness of the implementation of Instagram as a didactic tool to promote and facilitate student learning in the theoretical and laboratory courses of Pediatric Dentistry and Orthodontics during 2022. Private Instagram accounts were created for each of the four courses. During 4 months relevant information was posted to review concepts and strengthen the teaching-learning process of the students. At the end of the courses, a survey was conducted containing the following variables: usefulness of the social network, amount of information provided, preferred place to view content (wall or stories) and whether students recommend the use of Instagram in other courses of the Department of Dentistry and Orthodontics. For the association of variables, the chi-square test was used, value of p<0.05, 95%Cl. The participation in the accounts was 222 individuals; the interaction of the students with the accounts was 87.5% with respect to the stories, 95% observed the stories completely. There was a statistically significant difference with respect to where the information was posted: stories was the preferred place for students. There were 167 students participating in the survey. All the students found very useful or useful the content of the application on the social network.100% of the respondents recommended keeping the implementation of social networks in the theoretical courses of the Department. Instagram is not only a social application but also a channel to make the teaching process more dynamic and attractive. Teachers can integrate this social platform to foster motivation and learning in students.

Resumen Las redes sociales se han convertido en un espacio idóneo para el intercambio de información y conocimiento. El objetivo de este estudio fue determinar la utilidad de la implementación de Instagram como herramienta didáctica, para fomentar y facilitar el aprendizaje del estudiantado en los cursos teóricos y de laboratorio de Odontopediatría y Ortodoncia durante el 2022. Se crearon cuentas privadas en Instagram para cada uno de los cuatro cursos. Durante 4 meses se posteó información de relevancia para repasar conceptos y fortalecer el proceso de enseñanza- aprendizaje de los estudiantes. Al finalizar los cursos se realizó una encuesta que contenía las siguientes variables: utilidad de la red social, cantidad de información proporcionada, lugar preferido para ver el contenido (muro o historias) y si los estudiantes recomiendan el uso de Instagram en otros cursos del Departamento de Odontopediatría y Ortodoncia. Para la asociación de variables se utilizó la prueba de chi-cuadrado, el valor de p<0,05, 95%Cl. La participación en las cuentas fue de 222 individuos; la interacción de los estudiantes con las cuentas fue del 87,5% respecto a las historias, el 95% observaron las historias de forma completa. Hubo una diferencia estadísticamente significativa respecto al lugar donde se publicaba la información: las historias fue el lugar preferido por los estudiantes. La participación en la encuesta fue de 167 estudiantes. A todos los estudiantes les resultó muy útil o útil el contenido en la red social. El 100% de los encuestados recomendaron mantener la implementación de las redes sociales en los cursos teóricos del Departamento. Instagram no es solo una aplicación de carácter social, sino que constituye un canal para hacer el proceso de enseñanza más dinámico y atractivo. Los docentes pueden integrar esta plataforma social para fomentar la motivación y el aprendizaje en los estudiantes.

RESUMO A pandemia da Covid-19 colocou importantes desafios sanitários e económicos aos Estados e às suas burocracias. Tanto nos países desenvolvidos como nos países em desenvolvimento, as políticas implementadas reativaram as discussões sobre o papel do Estado e os seus graus de intervenção. Da mesma forma, implicaram mudanças nas condições de trabalho dos servidores públicos em função das medidas de cuidado e isolamento adotadas. Estas mudanças tiveram impacto na dinâmica das disputas trabalhistas no sector? Os conflitos registrados apresentaram novas características? Houve diferenças dependendo do nível de governo? Este artigo analisa os conflitos trabalhistas promovidos pelos trabalhadores das Administrações Públicas municipais, provinciais e nacional durante o período 2020-2022. Para caracterizar as estratégias adotadas nesta situação excepcional, são abordados especificamente os tipos de reclamações e o repertório de ações desenvolvidas foram aquelas com ou sem greve. Os dados são comparados também com os registros pré-pandêmicos. A análise desenvolvida alimenta-se da integração de dados da Base de Conflitos Trabalhistas do Ministério do Trabalho, Emprego e Seguridade Social, regulamentos, documentos oficiais e artigos de jornais. Este trabalho procura fornecer evidências empíricas que sirvam ao debate mais amplo sobre as disputas trabalhistas no setor público.

RESUMEN La pandemia de la Covid-19 concitó importantes desafíos sanitarios y económicos para los Estados y sus burocracias. Tanto en países desarrollados como en vías de desarrollo, las políticas implementadas para mitigar su impacto reactivaron las discusiones respecto del rol del Estado y sus grados de intervención. Asimismo, implicaron cambios en las condiciones de trabajo de los empleados de las Administraciones Públicas pues debieron readaptar el modo de desempeñar sus tareas ante las medidas de cuidado y aislamiento dispuestas. ¿Estos cambios impactaron sobre la dinámica de la conflictividad laboral en el sector? ¿Los conflictos laborales registrados presentaron características novedosas? ¿Existieron diferencias según el nivel de gobierno? En este trabajo se analiza el caso argentino considerando los conflictos laborales impulsados por los trabajadores de las Administraciones Públicas municipales, provinciales y nacional durante el período 2020-2022. A fin de determinar las estrategias desplegadas en ese contexto de excepcionalidad, se abordan específicamente los tipos de reclamos planteados y el repertorio de acciones desarrolladas fueran éstas con o sin paro. Asimismo para ampliar la caracterización, los datos son comparados con lo ocurrido durante 2019, año previo a la declaración de la pandemia. El análisis realizado se nutre de la integración de datos provenientes de la Base de Conflictos Laborales del Ministerio de Trabajo, Empleo y Seguridad Social de la Nación (MTEySS), normativas, documentos oficiales y artículos periodísticos. Mediante este trabajo se procura aportar evidencia empírica que sirva al debate más amplio respecto de la conflictividad laboral en el sector público.

ABSTRACT The COVID-19 pandemic raised important health and economic challenges for the States and their bureaucracies. In both developed and developing countries, the policies implemented restarted the discussions regarding the role of the State and its degrees of intervention. Likewise, they implied changes in public servants’ working conditions in light of care and isolation measures taken. Did these changes have an impact on Public Administration labor conflict dynamic? Did labor conflicts present new characteristics under pandemic context? Were there any differences depending on the level of government? This paper analyzes labor conflicts promoted by Argentine public servants of municipal, provincial and national Public Administrations during the period 2020-2022. In order to characterize their strategies in this exceptional situation, the types of claims and their repertoire of actions (strike and non-strike disputes) are specifically addressed. The data are also compared with pre-pandemic figures. The analysis is based on the data of the Labor Conflict Base of the National Ministry of Labor, Employment and Social Security, regulations, official documents and newspaper articles. This work provides empirical evidence that contributes to the broadest debate about the labor conflicts in the public sector.

Resumen Uno de los principales desafíos de las instituciones públicas de ciencia y tecnología radica en alinear las actividades y resultados de la investigación con la agenda de I+D y los lineamientos estratégicos definidos institucionalmente. Dentro de los factores que definen este alineamiento se encuentran las publicaciones científicas, consideradas incluso en muchos casos como el principal producto de las actividades de investigación. En el caso del Instituto Nacional de Investigación Agropecuaria (INIA) de Uruguay se definió como política institucional el mejorar los indicadores de cantidad y calidad de publicaciones científicas arbitradas. Para cumplir este objetivo se definieron diferentes acciones a implementar. Con el objetivo de monitorear los resultados de estas se realizó un estudio bibliométrico de las publicaciones del INIA en el período 2011-2022. El artículo que aquí se propone presenta los resultados obtenidos, permitiendo la discusión acerca de la pertinencia estratégica, la evolución, la conformación de grupos de trabajo y las vinculaciones institucionales en relación con la publicación de artículos científicos. Este tipo de análisis contribuye a la revisión continua de la estrategia institucional de forma ágil, dinámica y eficiente.

Abstract One of the main challenges for public science and technology institutions lies in aligning research activities and outcomes with the R&D agenda and institutionally defined strategic guidelines. Among the factors defining this alignment, scientific publications stand out, often considered the primary product of research activities. The National Institute of Agricultural Research (INIA) in Uruguay has established the enhancement of indicators for the quantity and quality of peer-reviewed scientific publications as an institutional policy. Various actions were defined to achieve this objective. To monitor the results of these actions, a bibliometric study of INIA's publications for the period 2011-2022 was conducted. This article presents the obtained results, facilitating a discussion on strategic relevance, evolution, the formation of workgroups, and institutional linkages related to the publication of scientific articles. Such analyses contribute to the ongoing review of institutional strategy in an agile, dynamic, and efficient manner.

Resumo Um dos principais desafios das instituições públicas de ciência e tecnologia reside no alinhamento das atividades e resultados de investigação com a agenda de I&D e com as orientações estratégicas definidas institucionalmente. Entre os fatores que definem esse alinhamento estão as publicações científicas, mesmo consideradas em muitos casos como o principal produto das atividades de pesquisa. No caso do Instituto Nacional de Pesquisa Agropecuária (INIA) do Uruguai, foi definido como uma política institucional para melhorar os indicadores de quantidade e qualidade das publicações científicas revisadas por pares. Para cumprir este objetivo foram definidas diferentes ações a implementar. Com o objetivo de monitorizar os resultados destes, foi realizado um estudo bibliométrico das publicações do INIA no período 2011-2022. O artigo aqui proposto apresentará os resultados obtidos, permitindo a discussão sobre a relevância estratégica, a evolução, a formação de grupos de trabalho e vínculos institucionais em relação à publicação de artigos científicos. Este tipo de análise contribui para a revisão contínua da estratégia institucional de forma ágil, dinâmica e eficiente.

ABSTRACT This study examines the relationship between business adaptability and superior performance. The researchers used Exploratory Factor Analysis and Kruskal-Wallis statistics to analyze data from a survey of 227 companies associated with a University Center. The study found that the Triad Model of Dynamic Capabilities, which includes Sense, Seize, and Transform components, explained 78.38% of the variance in business adaptability. The findings confirm the importance of Sense, Seize, and Transform capabilities in sustaining competitive advantage, as demonstrated by the observed superior performance of the organizations. The paper's originality lies in identifying higher-order capabilities associated with business adaptability in organizations across different sectors.

RESUMEN Este estudio examina la relación entre la adaptabilidad empresarial y el rendimiento superior. Los investigadores utilizaron Análisis Factorial Exploratorio y estadísticas de Kruskal-Wallis para analizar datos de una encuesta de 227 empresas asociadas a un Centro Universitario. El estudio encontró que el modelo tríada de capacidades dinámicas, que incluye componentes Detección, Aprovechamiento y Transformación, explica el 78,38% de la variación en la adaptabilidad empresarial. Los hallazgos del estudio confirman la importancia de las capacidades de detección, aprovechamiento y transformación para mantener la ventaja competitiva, como lo demuestra el desempeño superior observado de las organizaciones. La originalidad del estudio radica en identificar capacidades de orden superior asociadas con la adaptabilidad empresarial en organizaciones de diferentes sectores.

ABSTRACT Professionals in careers related to Information and Communication Technologies (ICT) are among the most in demand worldwide, but various media and studies have reported that the demand for them far exceeds the current supply. Paraguay does not escape this reality, so this paper seeks to analyze the academic offer of this type of career and the number of graduates who graduate from them through the quantitative analysis of open data provided by the Ministry of Education and Sciences. For this purpose, the Excel tool was used, importing the source data in csv format and using mainly dynamic tables and some functions described in the work. It is observed that both the academic offer and the percentage of graduates of the total are very low, in both cases not exceeding 2% of the total, data that coincides with the few previous studies on the subject. However, some aspects that affect this result are mentioned in the work, specifically referring to the cleaning and standardization of the data used for the study.

RESUMEN Los profesionales de las carreras relacionadas a las Tecnologías de la Información y Comunicación (TIC) son de los más demandados a nivel mundial, pero varios medios y estudios han informado que la demanda de estos supera por mucho la oferta actual. Paraguay no escapa de esta realidad por lo que el presente trabajo busca analizar la oferta académica de este tipo de carreras y la cantidad de egresados que se titulan en las mismas a través del análisis cuantitativo de los datos abiertos provistos por el Ministerio de Educación y Ciencias. Para el efecto se utilizó la herramienta Excel importando los datos de origen en formato csv y utilizando principalmente tablas dinámicas y algunas funciones descriptas en el trabajo. Se observa que tanto la oferta académica como el porcentaje de egresados del total son muy bajos no superando en ambos casos el 2% del total, dato que coincide con los pocos estudios anteriores sobre el tema. No obstante, se mencionan en el trabajo algunos aspectos que inciden en este resultado, referidos específicamente a la limpieza y estandarización de los datos utilizados para el estudio.

The present work reports on the isolation and characterisation of two novel antiviral ester compounds from dichloromethane leaf extracts of Spondias mombin (SM). The characterisation and structural elucidation were established from spectroscopic evidence of nuclear magnetic resonance, Fourier transform infrared and mass spectroscopy. The compounds identified were 6-methylheptyl pentadecanoate and 6-methylheptyl-15-(1,2,3,4,4a,8a-hexahydronaphthalen-1-yl)pentadecanoate. The novel isolated ester compounds were reported to have anti-rhino virus activity in silico against a known biological target (HsNMT1) that plays a key role in developing therapeutics against the common cold. Molecular docking analysis revealed the binding affinity across all targets within the range of -4.6 to -8.2 kcal/mol, whilst molecular dynamic simulation showed that systems attained good stability due to the maintenance of mean root-mean-square deviation values within the acceptable range of 1.5-2.5 Å. It can be concluded that the novel compounds are potential inhibitory candidates against rhinovirus protein target HsNMT1. However, in vitro and in vivo experiments are further required to validate the possible inhibitory candidates against rhinovirus disease (common cold). SIGNIFICANCE: The significance of this study contributes to the scientific rationale for using SM leaf extracts to treat viral diseases. Two novel compounds, 6-methylheptyl pentadecanoate and 6-methylheptyl-15-(1,2,3,4,4a,8a-hexahydronaphthalen-1-yl)pentadecanoate, were predicted through computer-aided techniques to possess anti-rhinovirus properties.