In recent years, the field of coordination chemistry has experienced a surge in interest regarding the synthesis and characterization of coordination complexes for diverse applications. This study is dedicated to investigating coordination compounds resulting from the interaction of nonsteroidal anti-inflammatory drugs (NSAIDs) with metal ions. The study research places significant emphasis on understanding the stability and thermal behavior of these coordination compounds. The utilization of thermoanalytical techniques is crucial in achieving this goal. Thermal analysis and thermokinetics provide valuable insights into the underlying mechanisms, kinetics, and energetics of these reactions, thereby facilitating the optimization of synthesis procedures. The research employs concurrent techniques, namely thermogravimetric analysis (TG) and differential scanning calorimetry (DSC), to explore the thermal stability and decomposition pathways of these coordination compounds. Thermokinetic models and optimization methodologies are subsequently applied to identify key reaction parameters. The primary aim of this research is to unveil the thermal behavior, stability, and reaction kinetics of aceclofenac coordination compounds, thus contributing significantly to the understanding of thermokinetics and thermal analysis in the domain of coordination chemistry. Specifically, this study is focused on aceclofenac coordination complexes involving lanthanum and gadolinium, with the ultimate goal of advancing the field of coordination chemistry. years applications antiinflammatory anti inflammatory NSAIDs (NSAIDs ions mechanisms reactions procedures TG (TG DSC, DSC , (DSC) parameters Specifically gadolinium (DSC

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stands for being the most serious epidemic (so far) of the 21st century. However, only a few computational studies have investigated the molecular mechanisms underlying the neutralization of the spike protein by antibodies of different classes. Hence, bioinformatic methods were employed to unravel the factors contributing to the remarkable neutralization capacity exhibited by specific antibodies. Initially, crystallographic structures of IgA monomeric / dimeric, IgG, and IgM antibodies binding with the receptor-binding domain region of the SARS-CoV-2 spike protein were retrieved. Subsequently, rigid molecular docking and molecular dynamic simulations were performed over 100 ns with explicit water solvation. Lastly, an energy decomposition was conducted to estimate the binding affinity using the last frames from molecular dynamics. The results revealed a higher binding affinity for both monomeric and dimeric forms of IgA antibodies against the spike protein. Additionally, a greater number of hydrogen bonds were observed during their interaction with the spike protein, as well as greater structural instability along the time and especially a more thermodynamically favorable interaction affinity. In this way, the research contributes a small piece to the complex puzzle of understanding the humoral immune response induced by the SARS-CoV-2 virus. SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 so far st century However classes Hence Initially IgG receptorbinding receptor SARS-CoV- retrieved Subsequently 10 solvation Lastly dynamics Additionally way virus (SARS-CoV- SARS-CoV 1 (SARS-CoV

RESUMO Objetivo: Avaliar a funcionalidade e fatores associados em crianças e adolescentes com osteogênese imperfeita (OI). Métodos: Estudo transversal com 30 crianças e adolescentes com OI. Foram avaliados prontuários médicos, uso de bisfosfonatos, características socioeconômicas, dinamometria de preensão palmar, equilíbrio, hipermobilidade articular, nível de deambulação e escores do Pediatric Evaluation of Disability Inventory - Computer Adaptative Test (PEDI-CAT). Os dados foram apresentados em média e desvio padrão e comparados por teste t por Mann-Whitney, enquanto os categóricos foram apresentados em frequência e comparados pelo teste exato de Fisher. Análises intragrupos foram realizadas por análise de covariância (ANCOVA) ou Teste de Wilcoxon para postos sinalizados. O teste Tau-b de Kendall foi usado para correlações. Resultados: A idade variou de 6 a 18 anos. A amostra foi dividida em dois grupos de acordo com a gravidade da doença. Casos moderados/graves (n=10) apresentaram menor estatura e força muscular comparadas às dos leves (n=20). Fraqueza muscular foi observada em todos os casos de OI quando comparados à população normal. Não houve diferença nos domínios do PEDI-CAT com exceção do domínio mobilidade. Houve correlação entre o número de fraturas, tipo de OI, peso e equilíbrio e o domínio mobilidade; e entre os domínios Atividades Diárias e Mobilidade e Responsabilidade e Social/cognitivo do PEDI-CAT. Conclusões: Nossos achados sugerem que crianças com OI moderada/severa podem atingir o mesmo nível de funcionalidade que crianças com a forma leve. Fraturas podem ter grande influência no nível de funcionalidade e o tratamento deve enfocar a prevenção e a reabilitação desses eventos. Objetivo . (OI) Métodos 3 médicos bisfosfonatos socioeconômicas palmar articular PEDICAT. PEDICAT PEDI CAT (PEDI-CAT) MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney Fisher ANCOVA (ANCOVA sinalizados Taub Tau b correlações Resultados 1 anos doença moderadosgraves moderados graves n=10 n10 n 10 (n=10 n=20. n20 n=20 20 (n=20) normal mobilidade fraturas Socialcognitivo Social cognitivo CAT. Conclusões moderadasevera moderada severa leve eventos (OI (PEDI-CAT n=1 n1 (n=1 n2 n=2 2 (n=20 n= (n= (n=2 (n

ABSTRACT Objective: The aim of this study was to evaluate the functioning and associated factors in children and adolescents with osteogenesis imperfecta (OI). Methods: This is a cross-sectional study conducted on 30 children and adolescents with OI. Medical records, use of bisphosphonates, socioeconomic status, handgrip strength, balance, joint hypermobility, ambulatory level, and the Pediatric Evaluation of Disability Inventory—Computer Adaptative Test (PEDI-CAT) scores were assessed. Data is presented as mean and standard deviation and Student’s t-test or Mann–Whitney U test. Categorical data is presented as frequency and analyzed using Fisher’s exact test. Within-group analyses were conducted using ANCOVA or Wilcoxon signed-rank test. Correlations used Kendall’s Tau-b test. Results: The participants involved in this study were 6–18 years old. The sample was separated into two groups according to disease severity. The moderate/severe OI group (n=10) presented a lower height and muscular strength than the mild group (n=20). Muscle weakness was observed in all participants with OI when compared with the normal population. No differences were observed between the groups in the PEDI-CAT scores except for the mobility domain. There were correlations between the PEDI-CAT mobility domain and the number of fractures, OI type, weight, and balance; there was also a correlation between the PEDI-CAT daily activities, mobility, responsibility, and social/cognitive domains. Conclusions: The findings suggest that children with moderate/severe forms of OI can achieve the same function levels as children with mild OI. Fractures can have a major influence on the functional level, and treatment should focus on the prevention and rehabilitation of these events when they occur. Objective . (OI) Methods crosssectional cross sectional 3 records bisphosphonates status balance hypermobility level InventoryComputer Inventory Computer PEDICAT PEDI CAT (PEDI-CAT assessed Students Student s ttest t test MannWhitney Mann Whitney Fishers Fisher Withingroup Within signedrank signed rank Kendalls Kendall Taub Tau b Results 618 6 18 6–1 old severity moderatesevere moderate severe n=10 n10 n 10 (n=10 n=20. n20 n=20 20 (n=20) population fractures type weight activities responsibility socialcognitive social cognitive domains Conclusions occur (OI 61 1 6– n=1 n1 (n=1 n2 n=2 2 (n=20 n= (n= (n=2 (n

ABSTRACT: With advancements in coffee cultivation, several traits may be considered in selection of plants, which must exhibit a set of favorable characteristics. The outturn index, defined as the relationship between the mass of mature fruit and processed beans, emerges as a key factor influencing productivity. This study characterized the outturn over two harvests of 57 clones marketed in the public domain and 10 registered cultivars. The analysis considers the effects of genotypes, measurements, and genetic progress achieved through plant selection. According to the maturation cycle of each clone, washed samples of cherry coffee were collected considering a completely randomized factorial design for characterization of the effects of genotypes, years, and the genotype × years (GY) interaction. The drying, peeling, and the outturn index were individually assessed. Despite the significant effects of the GY interaction, genotypes demonstrated minimal alterations in their ranking across measurements. Clones with higher outturn, including LB30, BRS1216, LB12, N7, LB10, LB20, BRS3220, and AS5, exhibited an average outturn of 25.51%, reflecting a gain of 12.17%. Conversely, clones with lower outturn, such as BG180, GJ30, GJ20, AS7, AS10, P42, N1, and P60, had an average of 19.15%, indicating a reduction of 14.02% compared to the general mean. Analyzing the distribution of the outturn values, 19.4%, 62.7%, and 17.9% of genotypes were classified as high, medium, and low outturn, respectively, providing valuable insights for optimal cultivation strategies. ABSTRACT plants characteristics beans productivity 5 1 cultivars measurements clone (GY interaction drying peeling assessed LB30 LB BRS1216 BRS LB12 N7 N LB10 LB20 BRS3220 AS5 AS 2551 25 51 25.51% 1217 12 17 12.17% Conversely BG180 BG GJ30 GJ GJ20 AS7 AS10 P42 P N1 P60 1915 19 15 19.15% 1402 14 02 14.02 mean values 194 4 19.4% 627 62 7 62.7% 179 9 17.9 high medium respectively strategies LB3 BRS121 LB1 LB2 BRS322 255 2 25.51 121 12.17 BG18 GJ3 GJ2 AS1 P4 P6 191 19.15 140 0 14.0 19.4 6 62.7 17. BRS12 BRS32 25.5 12.1 BG1 19.1 14. 19. 62. BRS1 BRS3 25. 12.

RESUMO: Com o avanço da cafeicultura, múltiplas características devem ser consideradas na seleção de plantas, que devem apresentar um conjunto de atributos favoráveis. O rendimento, definido como a relação de massas entre os frutos maduros e os grãos processados, é um importante componente da produtividade. Este estudo tem como objetivo caracterizar o rendimento ao longo de duas colheitas de 57 clones comercializados em domínio público e 10 cultivares registradas. A análise considera efeitos de genótipos, medições e estimativas de ganhos com a seleção. De acordo com o ciclo de maturação de cada clone, amostras de café cereja foram colhidas considerando um delineamento fatorial inteiramente ao acaso para a caracterização dos efeitos de genótipos, anos e interação genótipo × anos (GA). A secagem, o descascamento e o rendimento foram avaliados individualmente. Apesar dos efeitos significativos da interação GA, os genótipos apresentaram pequenas mudanças no ordenamento de uma medição para a outra. Clones com maior rendimento, entre eles, LB30, BRS1216, LB12, N7, LB10, LB20, BRS3220 e AS5 apresentaram rendimento médio de 25,51% associado a estimativas de ganho de 12,17%. Por outro lado, clones de menor rendimento, como BG180, GJ30, GJ20, AS7, AS10, P42, N1 e P60 tiveram uma média de 19,15% associada a uma redução de 14,02%. A partir da distribuição dos valores, 19,4, 62,7 e 17,9% dos genótipos apresentaram rendimento classificados como alto, médio e baixo, subsidiando o melhor cultivo dos genótipos avaliados. RESUMO cafeicultura plantas favoráveis processados produtividade 5 1 registradas clone GA. GA . (GA) secagem individualmente outra eles LB30 LB BRS1216 BRS LB12 N7 N LB10 LB20 BRS322 AS 2551 25 51 25,51 1217 12 17 12,17% lado BG180 BG GJ30 GJ GJ20 AS7 AS10 P42 P P6 1915 19 15 19,15 1402 14 02 14,02% valores 194 4 19,4 627 62 7 62, 179 9 17,9 alto baixo (GA LB3 BRS121 LB1 LB2 BRS32 255 2 25,5 121 12,17 BG18 GJ3 GJ2 AS1 P4 191 19,1 140 0 14,02 19, 6 17, BRS12 BRS3 25, 12,1 BG1 14,0 BRS1 12, 14,

ABSTRACT Nuclear magnetic resonance (NMR) is a spectroscopy technique widely used by chemists and physicists to determine the chemical structure of molecules that was adapted to generate imaging, known as nuclear magnetic resonance imaging (MRI), which is widely used in medical diagnosis. The importance of NMR in chemistry, physics, medicine, materials, and agriculture has been recognized with several Nobel Prizes in Physics, 1952, Chemistry, 1991 and 2002, and Medicine in 2003. Therefore, NMR can be applied to obtain: i) imaging of the human body, animal and materials; ii) high-resolution spectra to obtain structural and dynamical information of chemicals, materials etc.; and iii) quantitative and qualitative information of chemical composition of products such as food and agricultural products, using low-resolution relaxometry. High-resolution NMR and MRI have been applied in agri-food products, mostly as a research tool as they typically rely on expensive and bulk instruments, which restrict their uses in routine applications. The NMR sensors that have been more frequently used in agri-food products are based on low-resolution or low-field or time-domain NMR (TD-NMR) instruments. These low-cost instruments have been used for qualitative and quantitative analysis of agri-food products such as intact seeds and grains, intact fruits, meat, oils, and processed foods. In this paper, an overview of the NMR techniques and its main instrumentation aspects are presented, and some applications of TD-NMR and MRI in the non-invasive analysis of food, seeds, and others agricultural products are discussed. (NMR MRI, , (MRI) diagnosis chemistry physics medicine Physics 1952 Chemistry 199 2002 2003 Therefore i body ii highresolution high resolution chemicals etc. etc iii lowresolution low relaxometry Highresolution High agrifood agri lowfield field timedomain time domain TDNMR TD (TD-NMR lowcost cost grains fruits meat oils foods paper presented noninvasive non invasive discussed (MRI 195 19 200 1 20 2

RESUMO A ressonância magnética nuclear (RMN) é uma técnica de espectroscopia amplamente utilizada pelos químicos e físicos para determinar a estrutura química de moléculas que foi adaptada para gerar imagens, conhecidas como tomografia por imagem de ressonância magnética nuclear (IRM), amplamente utilizada em diagnóstico médico. A importância da RMN na química, física, medicina, materiais e agricultura tem sido reconhecida por vários Prémios Nobel de Física, 1952, Química, 1991 e 2002, e Medicina em 2003. Portanto, a RMN pode ser aplicada para obter: i) imagens do corpo humano, animais e materiais; ii) espectros de alta resolução para obtenção de informações estruturais e dinâmicas de produtos químicos, materiais etc.; e iii) obter informações quantitativas e qualitativas da composição química de alimentos, produtos agrícolas, utilizando relaxometria de baixa resolução. A IRM e a RMN de alta resolução tem sido aplicadas em produtos agroalimentares, principalmente na pesquisa, uma vez que normalmente dependem de instrumentos caros de grandes dimensões, o que restringe a sua utilização em aplicações rotineiras. Sensores de RMN que têm sido utilizados com mais frequência em produtos agroalimentares baseiam-se em instrumentos de baixa resolução ou de baixo campo ou domínio de tempo TD-NMR. Esses instrumentos de baixo custo tem sido utilizados para análises qualitativas e quantitativas de produtos agroalimentares, como sementes e grãos intactos, frutas intactas, carnes, óleos e alimentos processados. Neste artigo, é apresentada uma revisão das técnicas de RMN, seus principais aspectos da instrumentação, e discutidas algumas aplicações de TD-RMN e IRM na análise não invasiva de alimentos, sementes e outros produtos agrícolas. (RMN IRM, , (IRM) médico física medicina Física 1952 Química 199 2002 2003 Portanto i humano ii etc. etc iii agrícolas pesquisa dimensões rotineiras baseiamse baseiam se TDNMR. TDNMR TD NMR. NMR TD-NMR intactos intactas carnes processados artigo instrumentação TDRMN (IRM 195 19 200 1 20 2

Abstract Incorporating BIM in the education of professionals has become a demand and a topic of high importance for higher education. Several proposals for a curricular implementation of BIM exist. However, in most cases, they are specific to a single university or domain, do not consider academic policies or simplify practice by segmenting knowledge. This work proposes a protocol for the curricular implementation of BIM similar to the industry, considering aspects of process, technology, and policies aligned with the educational institution's mission and with existing competencies. Action research was the used method. Three actions were conducted: (1) proposition, (2) systematization and (3) application. The actions were executed in cycles incrementally, resulting in (1) guidelines, (2) supporting tools and (3) implementation plans. Two Brazilian universities participated in pilot studies of Project Construa Brasil. The pilot studies inspired a network of BIM cells that have synchronously applied curricular BIM implementation guidelines on a large scale. The guidelines proved to be generic and comprehensive, guiding the transformation with an empirical basis for the academics' decision-making. Leadership of a BIM specialist was confirmed as an essential factor of success. It is observed that even with a timid introduction of BIM competence in a limited scope of engineering solutions, the impact on the BIM maturity curriculum is significant. exist However cases domain knowledge industry process technology institutions institution s competencies method conducted 1 (1 proposition 2 (2 3 (3 application incrementally plans Brasil scale comprehensive academics decisionmaking. decisionmaking decision making. making decision-making success solutions significant (

Resumo Incorporar o BIM na formação de profissionais tornou-se uma demanda e um tema de grande importância para o ensino superior. Existem várias propostas de implementação curricular do BIM. No entanto, na maioria dos casos, são específicos de uma única universidade oudomínio, não contemplam políticas acadêmicas ou simplificam a prática segmentando o conhecimento. Este trabalho propõe um protocolo para a implementação curricular do BIM semelhante aoda indústria, considerando aspectos de processo, tecnologia e políticas alinhados com a missão da instituição de ensino e com as competências existentes. Pesquisa-ação foi o método utilizado. Três ações foram realizadas: (1) proposição, (2) sistematização e (3) aplicação. As ações foram realizadas em ciclos de forma incremental, resultando em (1) diretrizes, (2) ferramentas de apoio e (3) planos de implementação. Duas universidades brasileiras participaram de estudos-piloto do Projeto Construa Brasil. Os estudos-piloto inspiraram uma rede de células BIM que aplicaram as diretrizes curriculares de implementação BIM em larga escala. As diretrizes mostraram-se genéricas e abrangentes, orientando a transformação com base empírica para a tomada de decisão dos acadêmicos. A facilitação de um especialista BIM foi confirmada como fator essencial de sucesso. Observa-se que, mesmo com uma tímida introdução de competências BIM em um escopo limitado de soluções de engenharia, o impacto na maturidade BIM do currículo é significativo. tornouse tornou se superior entanto casos oudomínio conhecimento indústria processo existentes Pesquisaação Pesquisa ação utilizado 1 (1 proposição 2 (2 3 (3 aplicação incremental estudospiloto estudos piloto Brasil escala mostraramse mostraram abrangentes acadêmicos sucesso Observase Observa engenharia significativo (

Resumo A doença renal do diabetes (DRD) permanece como a principal causa de doença renal crônica (DRC) mundialmente. A patogênese da DRD é influenciada por mecanismos funcionais, histopatológicos e imunológicos, incluindo a atividade do inflamassoma NLRP3 e estresse oxidativo. Os inibidores do cotransportador de sódio-glicose 2 (iSGLT2) demonstraram benefícios metabólicos e a capacidade de retardar a progressão da DRD em diversos estudos clínicos ao longo dos anos. Estudos recentes sugerem que a atividade antidiabética também se estende à inibição da resposta inflamatória, incluindo modulação do inflamassoma NLRP3, redução de marcadores pró-inflamatórios e redução do estresse oxidativo. Aqui, avaliamos a eficácia dos iSGLT2 no tratamento da DRC e discutimos o papel da resposta inflamatória no desenvolvimento da DRD, incluindo sua relação com o inflamassoma NLRP3 e o estresse oxidativo. (DRD (DRC mundialmente funcionais imunológicos NLRP oxidativo sódioglicose sódio glicose iSGLT (iSGLT2 anos próinflamatórios pró inflamatórios Aqui (iSGLT

Abstract Diabetic kidney disease (DKD) remains the leading cause of chronic kidney disease (CKD) worldwide. The pathogenesis of DKD is influenced by functional, histopathological, and immune mechanisms, including NLRP3 inflammasome activity and oxidative stress. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) have shown metabolic benefits and the ability to slow the progression of DKD in several clinical studies over the years. Recent studies suggest that the antidiabetic activity also extends to inhibition of the inflammatory response, including modulation of the NLRP3 inflammasome, reduction of pro-inflammatory markers and reduction of oxidative stress. Here we review the efficacy of SGLT2i in the treatment of CKD and discuss the role of the inflammatory response in the development of DKD, including its relationship to the NLRP3 inflammasome and oxidative stress. (DKD (CKD worldwide functional histopathological mechanisms NLRP stress sodiumglucose sodium glucose SGLTi SGLT i (SGLT2i years proinflammatory pro

Abstract: This paper presents a methodology, based on frequency response models, to estimate the minimum or maximum value -nadir- that the frequency reaches when a generation - load unbalance occurs in the power system. To this end, the 1st order reduced equivalent model of the generator’s power-frequency control system is determined using the "Parameter Estimator" of Matlab/Simulink. Then, a set of equations coming from the reduced equivalent model is established to estimate the value of the maximum transient frequency deviation and its occurrence time. To illustrate the application of the proposed methodology, the IEEE New England test system has been chosen. Once this is done, the proposed methodology is applied to the Ecuadorian Interconnected Power System. The results of time domain simulations using the PowerFactory software are presented and compared with the results calculated using the developed reduced and analytical models. It is concluded that the proposed methodology estimates with high accuracy the maximum transient frequency deviation and its time of occurrence.

Resumen: En el presente trabajo se presenta una metodología, basada en modelos de repuesta de la frecuencia, para estimar el valor mínimo o máximo -nadir- que alcanza la frecuencia cuando en el sistema eléctrico de potencia se presenta un desbalance generación - carga. Con este fin, se determina el modelo reducido de 1er orden del sistema de control potencia - frecuencia del generador usando el “Estimador de Parámetros” de Matlab/Simulink. Luego, se establecen ecuaciones que provienen del modelo equivalente reducido para estimar el valor de la máxima desviación transitoria de la frecuencia y su tiempo de ocurrencia. Para ilustrar la aplicación de la metodología presentada se ha elegido el sistema de prueba IEEE New England de 39 barras y 10 generadores. Hecho esto, la metodología propuesta se aplica al Sistema Nacional Interconectado ecuatoriano. Se presentan resultados de simulaciones en el dominio del tiempo usando el programa PowerFactory, mismos que son comparados con los resultados calculados mediante el modelo equivalente reducido y el modelo analítico. Se concluye que la metodología propuesta estima con alta precisión la máxima desviación transitoria de la frecuencia y su tiempo de ocurrencia.

Resumen El trabajo consiste en una reconstrucción histórico-geografía por medio de la memoria de las personas residentes de la selva, utilizando la expresión popular avizinhar en la consolidación del concepto de Extractivismo en la amazonia acreana. La metodología se basa en análisis bibliográficos, documentos, trabajo de campo, entrevistas e imágenes de dominio público. El extractivismo se desarrolló a lo largo de la historia en todo el mundo, con diferentes sesgos: como actividad que tiene su acción ligada a una extracción sin precedentes de elementos de la naturaleza, extracción sin la debida preocupación por los daños colaterales o la ausencia de tales elementos en la composición del ecosistema. Sin embargo, el presente trabajo procura presentar y conceptualizar el extractivismo a partir de la experiencia de la Amazonía, en particular el estado brasileño de Acre que, a pesar de cumplir con la etimología de la palabra, “retirada, recolección de materiales de la naturaleza”, trasciende la extracción depredadora, y se revierte en luchas por la conservación de la naturaleza y de las vidas humanas que habitan las selvas. Estas acciones fueron lidereadas por Chico Mendes a mediados de la década de 1980 a través de la organización sindical de los trabajadores forestales iniciada en la década de 1970.

Abstract The work consists of a historical-geographical reconstruction, using the popular orkers avizinhar in the consolidation of the orkers Extractivism in the Acrean Amazon. The methodology is based on bibliographic analysis, documents, fieldwork, interviews, public domain images. Extractivism developed throughout history throughout the world, with orkers biases: as na activity that has its action linked to na unprecedented extraction of elements of nature, extraction without due concern for orkers damage or the absence of such elements in the composition of the ecosystem. However, the orkers work seeks to orkers and conceptualize extractivism from the experience of the Amazon, in particular the Brazilian state of Acre that, despite complying with the etymology of the word, “withdrawal, collection of materials from nature”, transcends predatory extraction, and reverts into struggles for the conservation of nature and human lives that inhabit the forests. These actions were led by Chico Mendes in the mid-1980s through the union organization of forestry orkers initiated in the 1970s.

Resumo O trabalho consiste em uma reconstrução histórico-geográfica, utilizando a expressão popular avizinhar na consolidação do conceito de Extrativismo na Amazônia acreana. A metodologia baseia-se em análise bibliográfica, documentos, trabalho de campo, entrevistas e imagens de domínio público. O extrativismo desenvolveu-se ao longo da história em todo o mundo, com diferentes vieses: como uma atividade que tem sua ação ligada a uma extração sem precedentes de elementos da natureza, extração sem a devida preocupação com danos colaterais ou a ausência de tais elementos na composição do ecossistema. No entanto, o presente trabalho busca apresentar e conceituar o extrativismo a partir da experiência da Amazônia, em particular do estado brasileiro do Acre que, apesar de obedecer à etimologia da palavra, “retirada, coleta de materiais da natureza”, transcende o extrativismo predatório, e se reverte em lutas pela conservação da natureza e das vidas humanas que habitam as florestas. Essas ações foram lideradas por Chico Mendes em meados da década de 1980 por meio da organização sindical dos trabalhadores florestais iniciada na década de 1970.

SUMMARY OBJECTIVE: The aim of this study was to demonstrate the effect of coronavirus disease 2019 on the cardiovascular autonomic system using heart rate variability in young individuals. METHODS: The study was designed retrospectively by scanning the 24-h Holter electrocardiography records of patients who applied to the Ankara Abdurrahman Yurtaslan Oncology Education and Research Hospital Cardiology outpatient clinic. The study group consisted of 492 patients under the age of 40 years, who did not have additional comorbidities or medication use and had prolonged symptoms after coronavirus disease 2019 during the pandemic. The control group, including 401 patients, was determined during the pre-pandemic period (before December 2019). Heart rate variability parameters were evaluated by scanning the 24-h Holter electrocardiography records of the patients and compared with the non-coronavirus disease 2019 group. RESULTS: The median age of participants was 30 years. Standard deviation of normal RR intervals (SDNN) ≤100 ms was more prevalent in the study group (27 (6.7%) vs 73 (14.8%), p<0.001). In univariate logistic regression analysis, the presence of coronavirus disease 2019 [(OR 2.41, 95%CI 1.52–3.83), p<0.001] and age [(OR 1.04, 95%CI 1.01–1.07), p=0.016] had a significant effect on the probability of SDNN≤100. In multivariate logistic regression analysis, the presence of coronavirus disease 2019 [(OR 2.42, 95%CI 1.52–3.85), p<0.001] and age [(OR 2.42, 95%CI 1.52–3.85), p=0.016] had a significant effect on the probability of SDNN≤100. Frequency domain measures such as, high-frequency values were significantly higher in the study group (p=0.029). The study group’s low-frequency/high frequency ratio was significantly lower (p=0.019). The low-frequency/high-frequency ratio’s cut-off value was ≤2.77. for determining the differentiation between coronavirus disease 2019 positive and negative cases in the receiver operating characteristic analysis. The sensitivity rate was 80.7%. The area under the curve value is 0.546 (p=0.019). CONCLUSION: This study showed that coronavirus disease 2019 causes reduced heart rate variability and increased parasympathetic activity in young patients. This may explain the prolonged symptoms after coronavirus disease 2019 infection. OBJECTIVE 201 individuals METHODS 24h h 24 clinic 49 4 years pandemic prepandemic pre before 2019. . 2019) noncoronavirus non RESULTS 3 SDNN (SDNN 100 ≤10 27 (2 6.7% 67 6 7 (6.7% 14.8%, 148 14.8% , 14 8 (14.8%) p<0.001. p0001 p p<0.001 0 001 p<0.001) analysis OR 241 2 41 2.41 95CI CI 95 1.52–3.83, 152383 1.52–3.83 1 52 83 1.52–3.83) 104 04 1.04 1.01–1.07, 101107 1.01–1.07 01 07 1.01–1.07) p=0.016 p0016 016 SDNN100 SDNN≤100 242 42 2.42 1.52–3.85, 152385 1.52–3.85 85 1.52–3.85) as highfrequency high p=0.029. p0029 p=0.029 029 (p=0.029) groups s lowfrequency/high lowfrequencyhigh low frequency/high p=0.019. p0019 p=0.019 019 (p=0.019) lowfrequency/highfrequency lowfrequencyhighfrequency ratios cutoff cut off 277 77 ≤2.77 807 80 80.7% 0546 546 0.54 CONCLUSION infection 20 10 ≤1 ( 6.7 (6.7 14.8 (14.8% p000 p<0.00 00 2.4 9 15238 1.52–3.8 5 1.0 10110 1.01–1.0 p=0.01 p001 SDNN10 SDNN≤10 p002 p=0.02 02 (p=0.029 lowfrequency frequencyhigh (p=0.019 ≤2.7 80.7 054 54 0.5 ≤ 6. (6. 14. (14.8 p00 p<0.0 2. 1523 1.52–3. 1. 1011 1.01–1. p=0.0 SDNN1 SDNN≤1 (p=0.02 (p=0.01 ≤2. 80. 05 0. (6 (14. p0 p<0. 152 1.52–3 101 1.01–1 p=0. SDNN≤ (p=0.0 ≤2 (14 p<0 15 1.52– 1.01– p=0 (p=0. (1 p< 1.52 1.01 p= (p=0 1.5 (p= (p

SUMMARY OBJECTIVE: The objective of this study was to analyze the genetic alterations of tumors within the scope of the homologous recombination deficiency gene panel in patients diagnosed with synchronous endometrial ovarian cancer who have been followed for over 5 years using next-generation sequencing. METHODS: DNA was isolated from the patient’s formalin-fixed, paraffin-embedded tissue blocks. Next-generation sequencing was performed using the Illumina capture-based sequencing method. Samples were sequenced using the Sophia HR Solution DNA Kit. RESULTS: Seven patients were included in this study. The ratios of likely pathogenic (LP)/pathogenic (P) somatic mutations in ATM (serine/threonine kinase or Ataxia-telangiectasia mutated gene), BRCA2 (breast cancer type 2 susceptibility gene), BARD1 (BRCA1 associated RING domain 1), TP53 (tumor protein p53), BIRP1 (BRCA1-interacting helicase 1 gene), PALB2 (partner and localizer of BRCA2), and CHECK2 were 21 (48.8%), 8 (18.6%), 5 (11.6%), 3 (6.9%), 2 (4.6%), 2 (4.6%), and 2 (4.6%), respectively, in endometrium, and the ratios of somatic mutations in ATM, BRCA2, TP53, BARD1, RAD54L (DNA repair/recombination protein like), BIRP1, and RAD51D (RAD51 recombinase paralog D) were 24 (60%), 6 (15%), 5 (12.5%), 2 (5%), 2 (5%), 1 (2.5%), and 1 (2.5%), respectively, in ovary. In endometrioid-synchronous endometrial ovarian cancer cases, P/LP mutations were observed in ATM and CHECK2 genes in endometrium and ATM, BRCA2, and TP53 genes in ovary. In two non-endometrioid-synchronous endometrial ovarian cancer cases, CHEK2 (checkpoint kinase 2) mutations were observed in endometrium and ATM and TP53 mutations in ovary, whereas in one case, P/LP mutations in ATM and TP53 genes were common in both tissues. CONCLUSION: Pathogenic variations confirming the diagnosis of synchronous endometrial ovarian cancer with genetic alterations were identified in all but one case. ATM gene mutation emerged as the most common alteration and has a potential association with a favorable prognosis. OBJECTIVE nextgeneration next generation METHODS patient s formalinfixed, formalinfixed formalin fixed, fixed formalin-fixed paraffinembedded paraffin embedded blocks Nextgeneration Next capturebased capture based method Kit RESULTS LP/pathogenic LPpathogenic LP /pathogenic P (P serine/threonine serinethreonine serine threonine Ataxiatelangiectasia Ataxia telangiectasia gene, , gene) BRCA breast BARD BRCA1 (BRCA 1, 1) TP TP5 tumor p53, p53 p p53) BIRP BRCA1interacting BRCAinteracting interacting PALB partner BRCA2) CHECK 48.8%, 488 48.8% 48 (48.8%) 18.6%, 186 18.6% 18 (18.6%) 11.6%, 116 11.6% 11 (11.6%) 6.9%, 69 6.9% 9 (6.9%) 4.6%, 46 4.6% 4 (4.6%) respectively RADL RAD L repairrecombination repair like, like like) RADD D RAD51 (RAD5 60%, 60 60% (60%) 15%, 15 15% (15%) 12.5%, 125 12.5% 12 (12.5%) 5%, 5% (5%) 2.5%, 25 2.5% (2.5%) ovary endometrioidsynchronous endometrioid cases PLP nonendometrioidsynchronous non CHEK checkpoint case tissues CONCLUSION prognosis p5 48.8 (48.8% 18.6 (18.6% 11.6 (11.6% 6.9 (6.9% 4.6 (4.6% RAD5 (RAD (60% (15% 12.5 (12.5% (5% 2.5 (2.5% 48. (48.8 18. (18.6 11. (11.6 6. (6.9 4. (4.6 (60 (15 12. (12.5 (5 2. (2.5 (48. (18. (11. (6. (4. (6 (1 (12. ( (2. (48 (18 (11 (4 (12 (2

Mining data on mental health topics such as depression on social media platforms presents a myriad of ethical challenges. This paper delves into the nuanced ethical considerations encountered during the collection of data on depression from social media platforms, highlighting the blurred and complex nature of research ethics in this domain. The paper investigates the ethical dilemmas inherent in mining data in the public domain of social media. It addresses concerns related to privacy, consent, and the potential for harm to participants, emphasising the difficulty in distinguishing between public expression and private disclosure in online spaces. Furthermore, the paper explores the challenges of ensuring the confidentiality and anonymity of participants in studies involving mental health issues. It discusses the tension between the need to protect individuals' identities and the imperative to analyse data in a meaningful way, while also acknowledging the risk of re-identification. Moreover, the paper reflects on the ethical implications of engaging with vulnerable populations and the responsibility of researchers to minimise harm and prioritise the well-being of participants. It discusses the importance of employing sensitive and ethical research methods when studying individuals' experiences with depression on social media platforms. Throughout, the paper underscores the importance of ongoing ethical reflection in navigating the complex landscape of social media research. By sharing personal experiences and insights, it aims to contribute to a deeper understanding of the ethical challenges inherent in mining data on social media, ultimately advocating for ethical research practices that prioritise participant well-being and uphold research integrity.

Abstract Introduction. Giant hernias with loss of domain are those whose hernial sac reaches the midpoint of the thigh in standing position and whose content exceeds the volume of the abdominal cavity. These hernias are a surgical challenge given the difficult reduction of their contents and the primary fascial closure, with a higher risk of complications associated with abdominal compartment syndrome, as well as a higher rate of recurrence and morbidity in patients. Clinical case. A 81-year-old male patient with comorbidity, reconsulting due to a symptomatic giant right inguinoscrotal hernia of two years of evolution, with a Tanaka index of 24%, eligible for a sequential pneumoperitoneum protocol (up to a total of 11,000 cc in cavity) plus application of botulinum toxin (two sessions) in the abdominal wall. Results. Successful correction of the patient’s giant inguinoscrotal hernia was achieved using this protocol, without recurrence of his abdomino-inguinal pathology and satisfaction with the procedure after one year. Conclusion. The sequential pneumoperitoneum protocol continues to be an important alternative in cases with a high risk of complications that require additional reconstructive techniques, while the previous application of botulinum toxin is a considerable adjuvant to further increase the rate of favorable results. However, research in the area should be encouraged to reaffirm its effectiveness.

Resumen Introducción. Las hernias gigantes con pérdida de domicilio son aquellas cuyo saco herniario alcanza el punto medio del muslo en bipedestación y su contenido excede el volumen de la cavidad abdominal. Estas hernias son un reto quirúrgico dada la difícil reducción de su contenido y del cierre primario de la fascia. Tienen mayor riesgo de complicaciones asociadas al síndrome compartimental abdominal, así como mayor tasa de recurrencia y morbilidad en los pacientes. Caso clínico. Paciente masculino de 81 años, reconsultante por hernia inguinoescrotal derecha gigante, de dos años de evolución, sintomática, con índice de Tanaka de 24 %. Se decidió aplicar el protocolo de neumoperitoneo secuencial (hasta 11.000 ml en total en cavidad) además de toxina botulínica en pared abdominal (dos sesiones). Resultados. Se logró la corrección exitosa de la hernia inguinoescrotal gigante, sin recaídas de su patología abdomino-inguinal. El paciente manifestó satisfacción con el tratamiento un año después del procedimiento. Conclusiones. El protocolo de neumoperitoneo secuencial es una alternativa en casos de hernias complejas, con alto riesgo de complicaciones, que requieren técnicas reconstructivas adicionales. La aplicación previa de toxina botulínica es un adyuvante considerable para aumentar la probabilidad de resultados favorables. Sin embargo, debe incentivarse la investigación en esta área para evaluar su efectividad.

ABSTRACT This work investigates the potentiality of the 2D electrical resistivity tomography method to delineate an altered intrusive rock domain. The detection and characterization of such altered domains are crucial to understanding local hydrogeological conditions. Here, the target is the San Luis area, located in the northern part of the Estibaná River watershed, within the Los Santos Province in the central region of the Isthmus of Panama. First, a detailed geological survey was carried out to better constrain the tectonic structures. Then, two geological sections were developed based on two 2D electrical resistivity tomographies. A geoelectrical simulation process was conducted in both sections to set theoretical models whose model responses (synthetic field data set) would be consistent with the observations. After appropriate selection of the inversion parameters by using the Boundless Electrical Resistivity Tomography (BERT) code, the observations were processed, resulting in low calculation errors (χ2 < 0.51). Based on the superficial geological information and the results of the geophysical modelling, two profiles were established, depicting the lateral and in-depth distribution of rocks and sediments. The limit of the Ocú-Parita fault zone was identified as well. The results of the 2D inversion of the synthetic data, obtained with the established theoretical models, are consistent with the 2D inversion of the observations. Electrical resistivity tomography studies can be useful in establishing groundwater management models, particularly in areas that experience severe water scarcity during the dry season.

RESUMEN Este trabajo investiga la capacidad del método de tomografía de resistividad eléctrica 2D para delinear un dominio de roca intrusiva alterada. La detección y caracterización de este tipo de intrusivos juega un papel importante en esclarecer el contexto hidrogeológico local. La zona de estudio corresponde al área de San Luis, ubicada en la parte norte de la cuenca del río Estibaná, provincia de Los Santos, región central del istmo de Panamá. Para reconocer las estructuras tectónicas de la zona, se realizó primero un levantamiento geológico superficial de detalle. Posteriormente, se efectuaron dos tomografías de resistividad eléctrica 2D a fin de confeccionar dos secciones geológicas. Un proceso de simulación geoeléctrica fue llevado a cabo en ambas secciones para establecer modelos teóricos cuyas respuestas (conjunto de datos de campo sintéticos) fuesen acordes con las observaciones. Posterior a la selección apropiada de los parámetros de inversión mediante el código BERT (Boundless Electrical Resistivity Tomography), las observaciones fueron procesadas, obteniéndose errores de cálculo bajos (χ2 < 0,51). Al combinar la información geológica de superficie y los resultados del modelado geofísico, se crearon dos perfiles geológicos donde es posible observar la distribución lateral y en profundidad de rocas y sedimentos, así como el límite de la zona de falla Ocú-Parita. Los resultados de la inversión 2D de los datos sintéticos obtenidos mediante los modelos teóricos establecidos concuerdan con aquellos de la inversión 2D de las observaciones. Estudios de tomografía de resistividad eléctrica pueden ser útiles en proporcionar modelos de gestión de agua subterránea, particularmente en áreas que experimentan escasez hídrica severa durante la temporada seca.

Abstract Introduction: professional codes of ethics should be updated periodically to respond to criticisms and demands arising from social, technological and scientific changes, especially in the field of human rights; Objectives: to verify the updating of the new Brazilian Code of Medical Ethics in the field of bioethics and human rights; Methods: document analysis of a document in the public domain, with previous definition of categories of analysis and registration units, with reference to the Unesco Universal Declaration of Bioethics and Human Rights. Results: the analysis showed the following most prevalent principles: dignity, autonomy, respect for human vulnerability and personal integrity, benefit and harmful effects, solidarity, privacy and confidentiality, non-discrimination and non-stigmatization; Not very well covered: people without the capacity for consent, social responsibility, protection of the environment and future generations; Absent: sharing of research benefits, equality, justice and equity, respect for cultural diversity and pluralism; Final considerations: the Brazilian Code of Medical Ethics values the maintenance of prudential autonomy in the relationship with patients and health professionals. The inclusion of broader social concerns, in a fragmentary and insufficient way, does not yet ensure the broad defense of public health, and the rights of people in vulnerability, who have historically been in a position of disparity. The application of the method in a specific context, of the pandemic, was useful for the understanding of the deontological and principlist limits applied to public health. A future revision is suggested based on Unesco's Universal Declaration of Bioethics and Human Rights and the deliberative method for interprofessional decision-making.

Resumo Introdução: os códigos profissionais de ética devem ser atualizados, periodicamente, para responder às críticas e demandas decorrentes de mudanças sociais, tecnológicas e científicas, especialmente no campo dos direitos humanos; Objetivos: verificar a atualização do novo Código de Ética Médica brasileiro ao campo da bioética e dos direitos humanos; Métodos: análise documental de documento de domínio público, com definição prévia de categorias de análise e unidades de registro, tendo como referencial teórico a Declaração Universal de Bioética e Direitos Humanos da Unesco. Resultados: a análise demonstrou como princípios mais prevalentes: dignidade, autonomia, respeito à vulnerabilidade humana e a integridade pessoal, benefício e efeitos nocivos, solidariedade, privacidade e confidencialidade, não discriminação e não estigmatização; pouco contemplados: pessoas sem capacidade de consentimento, responsabilidade social, proteção do meio ambiente e das gerações futuras; ausentes: repartição de benefícios da pesquisa, igualdade, justiça e equidade, respeito à diversidade cultural e ao pluralismo; Considerações finais: o Código de Ética Médica brasileiro preza pela manutenção de uma autonomia prudencial na relação com os pacientes e profissionais da saúde. A inclusão de preocupações sociais mais amplas, de forma fragmentária e insuficiente, não assegura ainda a ampla defesa da saúde pública, e dos direitos das pessoas em vulnerabilidade, situadas historicamente em posição de desigualdade. A aplicação do método em contexto específico, de pandemia, foi útil para a compreensão dos limites deontológicos e principialistas aplicados à saúde coletiva. Sugere-se uma futura revisão tendo como eixos a Declaração Universal de Bioética e Direitos Humanos da Unesco e o método deliberativo para tomada de decisões interprofissionais.