Résumé Dans cette note technique, nous présentons l’un des principaux legs empiriques de la recherche sur la publicité télévisée des candidats à la députation fédérale de l’État de Rio de Janeiro dans le cadre de la période de 1998 à 2018. Il s’agit d’introduire et de décrire le processus de collecte de cette base de données, les procédures utilisées au fil du temps pour la systématisation des informations et les utilisations possibles de deux bases de données liées à la recherche : la première ayant pour unité d’analyse les programmes électoraux enregistrés pendant la période ; et la seconde ayant pour unité d’analyse les candidats , comptabilisant le temps (en secondes) d’apparition dans le HGPE ; la performance électorale de chaque candidat (votes et résultat final) ; le financement de la campagne et d’autres caractéristiques politiques, sociales et démographiques. La base de données présentée couvre pas moins de 9 433 programmes électoraux enregistrés pendant la période nocturne, auxquels ont participé 1 774 candidatures. technique lun l un lÉtat État 199 2018 sagit s agit dintroduire d introduire danalyse analyse en secondes dapparition apparition votes final dautres autres politiques démographiques 43 nocturne 77 candidatures 19 201 4 7 20 2

Abstract In this technical note, we present one of the main empirical legacies of the research on the electoral campaign of candidates for Federal Deputy in the state of Rio de Janeiro during the free time granted by the government for electoral propaganda (Horário Gratuito de Propaganda Eleitoral − HGPE) from 1998 to 2018. The aim is to introduce and describe the process of data collection for this database, the procedures used over time for the systematization of information, and the potential uses of two databases linked to the research: the first analyzes the electoral programs recorded during the period and the second the unit of analysis is the individual candidates, coding the time (in seconds) of appearance in the HGPE, the electoral performance of the candidates (votes and final result), campaign financing, and other political, social, and demographic characteristics. The database includes 9,433 electoral programs broadcasted in the evening, in which 1,774 candidates participated. note Horário HGPE 199 2018 information seconds votes result, result , result) financing political social characteristics 9433 9 433 9,43 evening 1774 1 774 1,77 participated 19 201 943 43 9,4 177 77 1,7 20 94 4 9, 17 7 1, 2

Resumen En esta nota técnica, presentamos uno de los principales legados empíricos de la investigación sobre la publicidad televisiva de las candidatas/de los candidatos a diputado federal en el Estado de Río de Janeiro en los Horarios Gratuitos de Publicidad Electoral (HGPE) en el periodo de 1998 a 2018. El objetivo es presentar y describir el proceso de recopilación de esta base de datos, los procedimientos utilizados a lo largo del tiempo para sistematizar la información y los posibles usos de dos bases de datos vinculadas a la investigación: la primera tiene como unidad de análisis los programas electorales registrados durante el periodo; y la segunda tiene como unidad de análisis las candidatas/los candidatos, contabilizando el tiempo (en segundos) que aparecieron en el HGPE; el rendimiento electoral de cada candidato/candidata (votos y resultado final); la financiación de la campaña y otras características políticas, sociales y demográficas. La base de datos presentada incluye no menos de 9.433 programas electorales grabados por la noche, en los que participaron 1.774 candidatas/candidatos. técnica candidatasde candidatas HGPE (HGPE 199 2018 candidataslos segundos candidatocandidata candidato candidata votos final final) políticas demográficas 9433 9 433 9.43 noche 1774 1 774 1.77 candidatascandidatos candidatas/candidatos 19 201 943 43 9.4 177 77 1.7 20 94 4 9. 17 7 1. 2

Resumo Nesta nota técnica apresentamos um dos principais legados empíricos da pesquisa sobre propaganda das candidatas/dos candidatos a Deputado Federal do Estado do Rio de Janeiro no Horário Gratuito de Propaganda Eleitoral (HGPE) no período de 1998 a 2018. Trata-se de introduzir e descrever o processo de coleta dessa base de dados, os procedimentos utilizados ao longo do tempo para a sistematização das informações e os possíveis usos de dois bancos de dados vinculados à pesquisa: o primeiro possui como unidade de análise os programas eleitorais gravados no período; e, o segundo, possui como unidade de análise os/as candidatos/candidatas, contabilizando o tempo (em segundos) de aparição no HGPE; desempenho eleitoral de cada candidata/candidato (votos e resultado final); financiamento de campanha e outras características políticas, sociais e demográficas. O banco apresentado abarca nada menos do que 9.433 programas eleitorais gravados à noite, dos quais participaram 1.774 candidatos/candidatas. candidatasdos candidatas HGPE (HGPE 199 2018 Tratase Trata se segundo osas as candidatoscandidatas candidatos/candidatas em segundos candidatacandidato candidata candidato votos final final) políticas demográficas 9433 9 433 9.43 noite 1774 1 774 1.77 19 201 943 43 9.4 177 77 1.7 20 94 4 9. 17 7 1. 2

Résumé Cet article explore la grammaire institutionnelle de la protection des données et de la vie privée au Brésil. En adoptant la perspective analytique de l’Institutional Grammar Tool (IGT), nous déconstruisons les énoncés institutionnels des décrets réglementaires de la Loi Générale sur la Protection des Données des états brésiliens, afin de classifier les différents éléments grammaticaux informant les stratégies étatiques de protection et de gouvernance des données. Nous examinons dans cet article la construction des concepts de protection des données, de gouvernance des données et de vie privée, ainsi que la construction institutionnelle de la protection des données au Brésil. L’étude a une orientation empirique afin de répondre aux questions suivantes: quel est le dessin institutionnel des stratégies adoptées par les états, dans le contexte de la fédération, pour la protection des données personnelles et de la vie privée des citoyens? Quelles sont les implications de ce dessin pour l’efficacité de la protection des données au Brésil? L’article conclut que les stratégies de protection des données formulées au niveau des états sont davantage orientées vers le contrôle bureaucratique du traitement des données que vers la réalisation effective des droits émergents de la citoyenneté. Brésil lInstitutional l Institutional IGT, IGT , (IGT) brésiliens Létude L étude suivantes fédération citoyens lefficacité efficacité Larticle citoyenneté (IGT

Resumen Este artículo investiga la gramática institucional de la protección de datos y de la privacidad en Brasil. Adoptando la perspectiva analítica del Intitutional Grammar Tool (IGT), deconstruimos los enunciados institucionales de los decretos reglamentarios de la Ley General de Protección de Datos de los estados brasileros, con el fin de clasificar los diferentes elementos gramaticales que informaron las estrategias estaduales de protección y gobernanza de datos. Examinamos la construcción de los conceptos de protección de datos, gobernanza de datos y privacidad, así como la construcción institucional de la protección de datos en Brasil. El estudio tiene un abordaje empírico, con el fin de responder a las siguientes cuestiones: ¿cuál es el diseño institucional de las estrategias adoptadas por los estados, en el contexto de la federación, para la protección de datos personales y de la privacidad de los ciudadanos? ¿cuáles son las implicaciones de ese diseño para la efectividad de la protección de datos en Brasil? El artículo concluye que las estrategias de protección de datos formuladas en los estados tienen más un enfoque de control burocrático de tratamiento de datos que propiamente la implementación de derechos emergentes de ciudadanía. Brasil IGT, IGT , (IGT) brasileros empírico cuestiones cuál federación ciudadanos cuáles ciudadanía (IGT

Abstract This article investigates the institutional grammar of data protection and privacy in Brazil. By adopting the analytical lens of the Institutional Grammar Tool (IGT), it deconstructs the institutional statements within the regulatory decrees of the General Data Protection Law (LGPD) in Brazilian states, classifying the different grammatical elements that inform state-level strategies for data protection and governance. It examines how the concepts of data protection, data governance, and privacy are formulated, as well as the institutional construction of data protection in Brazil. By taking an empirical approach, it aims to address the following questions: What is the institutional design of the strategies adopted by Brazilian states, within the federation, to protect personal data and citizens’ privacy? What are the implications of this design on how effective data protection is in Brazil? The article concludes that the data protection strategies formulated by the states lean more toward bureaucratic control of data processing than the actual realization of emerging citizenship rights. Brazil IGT, IGT , (IGT) LGPD (LGPD statelevel state level governance approach questions federation citizens rights (IGT

Resumo Este artigo investiga a gramática institucional da proteção de dados e da privacidade no Brasil. Adotando a lente analítica do Intitutional Grammar Tool (IGT), desconstruímos os enunciados institucionais dos decretos regulamentadores da Lei Geral de Proteção de Dados dos estados brasileiros, de forma a classificar os diferentes elementos gramaticais que informam as estratégias estaduais de proteção e governança de dados. Examinamos nesse artigo a construção dos conceitos de proteção de dados, governança de dados e privacidade, assim como a construção institucional da proteção de dados no Brasil. O estudo tem um viés empírico, de maneira a responder às seguintes questões: qual o desenho institucional das estratégias adotadas pelos estados, no contexto da federação, para a proteção de dados pessoais e da privacidade dos cidadãos? Quais as implicações desse desenho para a efetividade da proteção de dados no Brasil? O artigo conclui que as estratégias de proteção de dados formuladas nos estados têm mais o viés de controle burocrático do tratamento de dados do que propriamente a efetivação de direitos emergentes de cidadania. Brasil IGT, IGT , (IGT) brasileiros empírico questões federação cidadãos cidadania (IGT

Résumé Cet article a pour but de démontrer la pertinence de l´approche transversale des chiffres et des cartes afin de mettre en évidence le pouvoir performatif qui se dégage de leurs intersections tecnhopolitiques telles que le concept de densité de population et la régionalisation du territoire. Appliquée au Brésil, l´étude croisée met en lumière des aspects du processus de construction de l´État, de la centralisation de l´autorité politique et de la création de nouvelles catégories de personnes et d´espaces de gouvernement. Pour ce faire, les tendances qui ont rapproché la statistique et la cartographie au cours de l´Empire brésilien y sont annalysées, en comprenant leur rôle en tant qu´instruments descriptifs du pouvoir souverain. De même, l´article aborde les circonstances qui conduissent à l´importance croissante des chiffres et des cartes comme une référente commune pour l´action collective et la production d´identités sociales. Basé sur le cadre de la sociologie de la quantification, l´article s´intéresse à l´émergence de la cartographie statistique et la régionalisation croissante des données officielles entre les années 1920 et 1940, liée à une nouvelle façon de definir la «brésilité », d´ordonner le territoire et de gouverner la population. On conclut que quantifier, c´est aussi visualiser et imaginer des grandeurs démographiques et économiques dans une spatialité cohérente et unitaire une fois stabilisée par des conventions d´équivalence. lapproche l approche Brésil létude étude lÉtat État l´État lautorité autorité despaces d espaces gouvernement faire lEmpire Empire annalysées quinstruments qu instruments souverain même larticle limportance importance laction action didentités identités sociales quantification sintéresse s intéresse lémergence émergence 192 1940 brésilité » dordonner ordonner quantifier cest c est déquivalence équivalence d´équivalence 19 194 1

Abstract This article takes a cross-disciplinary approach to numbers and maps to demonstrate the performative power that emerges from their technopolitical intersections, such as the concept of population density and regional delineation of territory. Applied to the Brazilian context, this combined analysis sheds light on aspects related to the construction of State authority and its power to create categories of people and places. To do so, this paper examines trends that bring statistics and cartography together in the Brazilian Empire, indicating a common status for maps and numbers as descriptive instruments of sovereign power, including their modes of use and conditions for producing and validating truth. Subsequently, it addresses the factors leading to the growing importance of numbers and maps for collective action and the production of shared identities. Drawing on references from the sociology of quantification, this paper focuses on the emergence of statistical cartography and the increasing regionalization of official data between the 1920s and 1940s – linked to a new way of defining Brazilian identity, organizing territory, and managing population. It concludes that quantifying is also visualizing demographic and economic quantities in a coherent and unitary spatiality, once stabilized by conventions of equivalence. crossdisciplinary cross disciplinary intersections territory context places so Empire truth Subsequently identities quantification s identity spatiality equivalence

Resumen Este artículo realiza un abordaje cruzado de números y mapas con el fin de evidenciar el poder performativo que emerge de sus intersecciones tecnopolíticas, como el concepto de densidad poblacional y el recorte regional del territorio. Aplicado al caso brasilero, el análisis combinado ilustra aspectos relativos a la construcción de la autoridad del Estado y su poder de crear categorías de personas y lugares. Para ese propósito, examinamos las tendencias que aproximan la estadística de la cartografía en Brasil Imperio y que indican un estatuto común a mapas y números como instrumentos descriptivos del poder soberano, sus modalidades de uso y sus condiciones de producción y validación de la verdad. Luego, abordamos los factores que conducen a la creciente importancia de los números y de los mapas para la acción colectiva y para la producción de identidades compartidas. Con base en las referencias de la sociología de la cuantificación, nos enfocamos en la emergencia de la cartografía estadística y en la creciente regionalización de los datos oficiales entre las décadas de 1920 y 1940, vinculadas a un nuevo modo de definir la “brasilidad”, ordenar el territorio y administrar la población. Concluimos que cuantificar es también visualizar cantidades demográficas y económicas en una espacialidad coherente y unitaria, una vez estabilizada por convenciones de equivalencia. tecnopolíticas brasilero lugares propósito soberano verdad Luego compartidas cuantificación 192 1940 brasilidad, brasilidad , “brasilidad” población unitaria equivalencia 19 194 “brasilidad 1

Resumo Este artigo realiza uma abordagem cruzada de números e mapas de modo a evidenciar o poder performativo que emerge de suas interseções tecnopolíticas, como o conceito de densidade populacional e o recorte regional do território. Aplicada ao caso brasileiro, a análise combinada ilumina aspectos relativos à construção da autoridade do Estado e seu poder de criar categorias de pessoas e lugares. Para tanto, examinamos as tendências que aproximam a estatística da cartografia no Brasil Império e que indicam um estatuto comum a mapas e números enquanto instrumentos descritivos do poder soberano, como suas modalidades de uso, e suas condições de produção e validação da verdade. Na sequência, abordamos os fatores que levam à crescente importância dos números e dos mapas para a ação coletiva e para a produção de identidades compartilhadas. Com base nas referências da sociologia da quantificação, enfocamos a emergência da cartografia estatística e a crescente regionalização dos dados oficiais, entre as décadas de 1920 e 1940, ligadas a um novo modo de definir a brasilidade, ordenar o território e gerir a população. Concluímos que quantificar é também visualizar quantidades demográficas e econômicas em uma espacialidade coerente e unitária, uma vez estabilizada por convenções de equivalência. tecnopolíticas brasileiro lugares tanto soberano uso verdade sequência compartilhadas quantificação oficiais 192 1940 brasilidade população unitária equivalência 19 194 1

Alzheimer’s disease (AD) is a most common form of dementia and results in memory loss, disorientation, impaired thinking and changes in personality as well as mood. The dementia cases mostly turn into the Alzheimer’s disease (AD). Another disease, the Parkinson’s disease (PD), mainly affects dopaminergic neurons in substantia nigra. A series of previously synthesized quinolone-triazole hybrids were investigated and evaluated for their anti-acetyl cholinesterase and against monoamine oxidase reactive properties through in silico characterization. The ground state electronic properties were determined by electron density of the compounds through DFTs (density functional theory) calculation. The geometries of all compounds were optimized using Becke-3-parameter-Lee-Yang-Parr (B3LYP) method and 6-311g basis set. Docking studies were conducted using the AutoDock and Molecular Operating Environment (MOE) software and the results of the potent derivatives found to be encouraging. The data confirmed that all the compounds have drug-like properties and was further confirmed by ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. Alzheimers Alzheimer s AD (AD loss disorientation mood AD. . Parkinsons Parkinson PD, PD , (PD) nigra quinolonetriazole quinolone triazole antiacetyl anti acetyl characterization theory calculation Becke3parameterLeeYangParr BeckeparameterLeeYangParr Becke 3 parameter Lee Yang Parr B3LYP BLYP B LYP (B3LYP 6311g g 6 311g set MOE (MOE encouraging druglike drug like absorption, absorption (absorption distribution metabolism toxicity (PD parameterLeeYangParr

Chemometrics is gaining more and more space in universities and industry. To contribute to the development and expansion of principal component analysis (PCA) teaching proposals, this work evaluated the answers of the students to a questionnaire and presented a didactic-pedagogical proposal that can contribute to solving the principal doubts achieved by students in the PCA interpretation. Based on data collected in a semi-open questionnaire, the proposal was developed based on methodological principles of historical-critical pedagogy, containing the objectives, the problems surrounding the topic, and the cultural instruments necessary for understanding and interpreting PCA in the discipline of chemometrics by using new resources and instruments, especially free software, Chemostat. This proposal covers topics related to the concept of chemometrics and PCA, the explanation of the data set, pre-processing, use of Chemostat software, and analysis of principal components. It is hoped that this proposal can promote a better understanding concerning PCA on the part of students, as well as effective incorporation of the phenomena that involve this tool and its applications, and interpretation. Likewise, it is expected that this didactic-pedagogical proposal can support new teaching practices in chemometrics subjects in higher education. industry (PCA proposals didacticpedagogical didactic pedagogical interpretation semiopen semi open historicalcritical historical critical pedagogy objectives topic software set preprocessing, preprocessing pre processing, processing pre-processing components applications Likewise education

The training of Chemistry teachers in Brazil has been researched for a few decades and studies point out to training gaps that reverberate in teaching, especially in basic education. One of the contents covered in this step and which is part of the high school curriculum is radioactivity, which is related, among other things, to radiological and radioactive accidents that occur around the world. Thus, this research sought to investigate how the training provided to Chemistry undergraduates in the state of Goiás is in relation to the subject of radioactivity, since in 1987 a radiological accident occurred in Goiânia with a Cesium 137 source. This is a qualitative research, data were collected via questionnaire and the analytical technique used was discursive textual analysis (ATD). The results showed that due importance was not given to the radiological accident, since there is evidence of training gaps in relation to the topic of radioactivity in Chemistry degree courses in the state of Goiás, where the accident occurred, and the contents on radioactivity are either not addressed, or the approach is superficial. This fact directly impacts the teacher’s performance in basic education, when working on this content with their students. teaching education related things world Thus 198 13 source ATD. ATD . (ATD) addressed superficial teacher s students 19 1 (ATD

Efavirenz, an antiretroviral drug, is a class 2 according to the biopharmaceutics classification system. Many dissolution enhancement systems have been tried and our group had success using wet milling to decrease particle size and granules were obtained by spray and freeze drying. In this paper we present data related to the upgrade in the process, raising the solids concentration in the suspension from 10 to 50% (m/v) and changing the drying step for a fluid bed granulation. After that, tablets were obtained. Granules and tablets were fully evaluated and a pharmacokinetic study was also performed with the granules. By powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FTIR) it was possible to prove that there was no phase transition in the sample after milling and drying. Dissolution efficiency of 4 from 5 granules was higher than 90%, considering 83% for the raw material. Tablets were technically approved but the dissolution was impacted and just 2 out of 11 showed results > 80%. A high enhancement in the bioavailability was also observed, around 172%. So, it is possible to conclude that efavirenz microcrystals with enhanced dissolution and bioavailability can be formulated into tablets and are a viable system to develop a new drug product. Efavirenz process 1 50 m/v mv m v (m/v granulation Xray X ray PXRD (PXRD FTIR (FTIR 90 90% 83 material 80 80% observed 172 172% So product 9 8 17

ABSTRACT Purpose: To describe the epidemiological and clinical profile of hospitalized patients with retinoblastoma in Brazil. Methods: Using data from the Hospital Cancer Registry of the Instituto Nacional de Câncer, patients with the morphological codes of retinoblastoma who were diagnosed between 2000 to 2018, aged 0–19 years, and followed up in registered hospitals (analytical cases) were selected. The relative and absolute frequencies of demographic, clinical, diagnostic, therapeutic, and outcome variables were described. Hospital performance indicators were calculated and compared between hospitals qualified and not qualified to treat pediatric oncology cases and between hospitals with different case volumes (<20, 20-75, >75 cases). Results: Of the 2,269 identified analytical cases from 86 institutions, 48% were from the Southeast, 54% were male, and 66% were aged <4 years. The proportion of missing data (NA) was too high for several variables. Approximately 84% of the patients were from the public health system, 40% had a positive family history, and 88% had unilateral involvement. The first treatment included surgery in 58.3% of the patients (NA=2), Approximately 36.6% of these patients achieved complete remission, 10.8% achieved partial remission, and 12.7% died (NA=59%). Hospital performance indicators were within the target in >90% of the patients. The median time between the first appointment and diagnosis (6 days, interquartile range [IQR] 1–14) was significantly lower and the median time to death was longer (343 days, IQR, 212-539) in high-volume hospitals (>75 cases) than in medium- and low-volume hospitals. Conclusions: Despite the high proportion of missing data, we found that the delay in diagnosis is due to prehospital factors. Additionally, there is a need for educational programs for healthcare professionals and families that emphasize early identification and referral to specialized centers. Future studies should focus on the impact of Hospital Cancer Registry data completeness on outcomes, causes of delay in diagnosis, regional inequalities, and barriers to accessing specialized services. Purpose Brazil Methods Câncer 200 2018 019 0 19 0–1 years selected demographic diagnostic therapeutic described <20, 20 (<20 2075, 2075 75, 75 20-75 >7 cases. . Results 2269 2 269 2,26 8 institutions 48 Southeast 54 male 66 4 < NA (NA 84 system 40 history 88 involvement 583 58 3 58.3 NA=2, NA2 NA=2 , (NA=2) 366 36 6 36.6 remission 108 10 10.8 127 12 7 12.7 NA=59%. NA59 NA=59% 59 (NA=59%) 90 >90 ( days IQR [IQR 1–14 114 1 14 343 (34 212539 212 539 212-539 highvolume volume (>7 medium lowvolume low Conclusions factors Additionally centers outcomes inequalities services 201 01 0– <20 (<2 207 20-7 > 226 26 2,2 5 58. NA= (NA=2 36. 10. 12. NA5 NA=59 (NA=59% 9 >9 1–1 11 34 (3 21253 21 53 212-53 (> <2 (< 20- 22 2, (NA= NA=5 (NA=59 1– 2125 212-5 (NA=5 212-

ABSTRACT Purpose: This study aimed to compare the safety and effectiveness of intraocular pressure reduction between micropulse transscleral cyclophotocoagulation and “slow cook” transscleral cyclophotocoagulation in patients with refractory primary open-angle glaucoma. Methods: We included patients with primary open angle glaucoma with at least 12 months of follow-up. We collected and analyzed data on the preoperative characteristics and postoperative outcomes. The primary outcomes were a reduction of ≥20% of the baseline value (criterion A) and/or intraocular pressure between 6 and 21 mmHg (criterion B). Results: We included 128 eyes with primary open-angle glaucoma. The preoperative mean intraocular pressure was 25.53 ± 6.40 and 35.02 ± 12.57 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean intraocular pressure was reduced significantly to 14.33 ± 3.40 and 15.37 ± 5.85 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups at the last follow-up, respectively (p=0.110). The mean intraocular pressure reduction at 12 months was 11.20 ± 11.46 and 19.65 ± 13.22 mmHg in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The median preoperative logMAR visual acuity was 0.52 ± 0.69 and 1.75 ± 1.04 in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p<0.001). The mean visual acuity variation was −0.10 ± 0.35 and −0.074 ± 0.16 in the micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p=0.510). Preoperatively, the mean eye drops were 3.44 ± 1.38 and 2.89 ± 0.68 drugs in the micropulse- and “slow cook” transscleral cyclophotocoagulation groups, respectively (p=0.017), but those were 2.06 ± 1.42 and 1.02 ± 1.46 at the end of the study in the “slow cook” and micropulse transscleral cyclophotocoagulation groups, respectively (p<0.001). The success of criterion A was not significant between both groups. Compared with 11 eyes (17.74%) in the “slow cook” transscleral cyclophotocoagulation group, 19 eyes (28.78%) in the micropulse transscleral cyclophotocoagulation group showed complete success (p=0.171). For criterion B, 28 (42.42%) and 2 eyes (3.22%) showed complete success after micropulse- and “slow cook” transscleral cyclophotocoagulation, respectively (p<0.001). Conclusion: Both techniques reduced intraocular pressure effectively. Purpose slow cook openangle Methods 1 followup. followup follow up. up follow-up 20 ≥20 andor or B. B . B) Results 2553 25 53 25.5 640 40 6.4 3502 35 02 35.0 1257 57 12.5 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 1433 14 33 14.3 340 3 3.4 1537 15 37 15.3 585 5 85 5.8 followup, up, p=0.110. p0110 p=0.110 110 (p=0.110) 1120 11.2 1146 46 11.4 1965 65 19.6 1322 13 22 13.2 052 52 0.5 069 69 0.6 175 75 1.7 104 04 1.0 010 10 −0.1 035 0.3 0074 074 −0.07 016 16 0.1 p=0.510. p0510 p=0.510 510 (p=0.510) Preoperatively 344 44 138 38 1.3 289 89 2.8 068 68 p=0.017, p0017 p=0.017 , 017 (p=0.017) 206 06 2.0 142 42 1.4 102 146 17.74% 1774 17 74 (17.74% 28.78% 2878 78 (28.78% p=0.171. p0171 p=0.171 171 (p=0.171) 42.42% 4242 (42.42% 3.22% 322 (3.22% Conclusion effectively ≥2 255 25. 64 4 6. 350 35. 125 12. p000 p<0.00 00 (p<0.001 143 14. 34 3. 153 15. 58 8 5. p011 p=0.11 (p=0.110 112 11. 114 196 19. 132 13. 05 0. 7 1. 01 −0. 03 007 07 −0.0 p051 p=0.51 51 (p=0.510 2. p001 p=0.01 (p=0.017 17.74 177 (17.74 28.78 287 (28.78 p017 p=0.17 (p=0.171 42.42 424 (42.42 3.22 32 (3.22 ≥ p00 p<0.0 (p<0.00 p01 p=0.1 (p=0.11 −0 p05 p=0.5 (p=0.51 p=0.0 (p=0.01 17.7 (17.7 28.7 (28.7 (p=0.17 42.4 (42.4 3.2 (3.2 p0 p<0. (p<0.0 p=0. (p=0.1 − (p=0.5 (p=0.0 17. (17. 28. (28. 42. (42. (3. p<0 (p<0. p=0 (p=0. (17 (28 (42 (3 p< (p<0 p= (p=0 (1 (2 (4 ( (p< (p= (p

ABSTRACT Purpose: To determine the clinical outcomes in patients after type 1 Boston keratoprosthesis surgery and the significance of ultrasound biomicroscopy imaging for postoperative follow-up. Methods: This retrospective analysis included 20 eyes of 19 patients who underwent corneal transplantation with type 1 Boston keratoprosthesis between April 2014 and December 2021. Data on patient demographics, preoperative diagnosis, visual acuity, and postoperative clinical findings were analyzed. Results: Type 1 Boston keratoprosthesis implantation resulted in intermediate- and long-term positive outcomes. However, blindness and other serious complications such as glaucoma, retroprosthetic membrane formation, endophthalmitis, or retinal detachment also occurred. The use of ultrasound biomicroscopy imaging allowed for better evaluation of the back of the titanium plate, anterior segment structures, and the relationship of the prosthesis with surrounding tissues, which provided valuable postoperative information. Conclusion: Regular lifetime monitoring and treatment are necessary in patients who undergo Boston type 1 keratoprosthesis implantation for high-risk corneal transplantation. ultrasound biomicroscopy imaging can be a valuable imaging technique for the evaluation of patients with Boston type 1 keratoprosthesis, providing important information on anterior segment anatomy and potential complications. Further studies and consensus on postoperative follow-up protocols are required to optimize the management of patients with Boston type 1 keratoprosthesis. Purpose followup. followup follow up. up Methods 2 201 2021 demographics diagnosis acuity analyzed Results intermediate longterm long term However glaucoma formation endophthalmitis occurred plate structures tissues Conclusion highrisk high risk 202

Parthenolide (PTN) is a secondary metabolite of the plant Tanacetum parthenium (L.) Schulz Bip. and is considered the chemical marker of this species. This sesquiterpene lactone (germacrene skeleton) has been described as responsible for the biological activity of the leaf extract. In addition, several studies in the literature have demonstrated its antiparasitic and antineoplastic activity. However, there is a need for knowledge of other safety parameters, such as pharmacokinetic, pharmacodynamic and toxicity evaluations. Therefore, in this investigation, the in vitro metabolism of parthenolide was performed with rat liver microsomes and biomimetic metabolism (such as cytochrome P-450 system) using organometallic catalysts. The biomimetic procedure was validated since the major compound of biomimetic oxidative reaction with meta-chloroperbenzoic acid catalyzed by metalloporphyrin 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin iron(III) chloride was also observed with rat liver microsomes. Previous chemoenzymatic synthesis studies of PTN afforded the same epoxide formation, this major oxidative compound was isolated and fully characterized as (1 R,10R)-epoxyparthenolide based on experimental and theoretical calculations of infrared (IR) and vibrational circular dichroism (VCD) data at the B3PW91/6-311G. Furthermore, for the first time, this metabolite was evaluated for trypanocidal and leishmanicidal activity. The mean inhibitory concentration (IC50) values were lower for PTN than its metabolite and showed significant cytotoxic effects for both parasites. This finding holds promise for addressing neglected diseases. (PTN L. L (L. Bip species germacrene skeleton extract addition However parameters pharmacokinetic evaluations Therefore investigation P450 P 450 P-45 system catalysts metachloroperbenzoic meta chloroperbenzoic 5,10,15,20tetrakispentafluorophenylporphyrin 5101520tetrakispentafluorophenylporphyrin tetrakispentafluorophenylporphyrin 5,10,15,20 tetrakis pentafluorophenyl porphyrin 5 10 15 20 ironIII iron III iron(III formation 1 ( R,10Repoxyparthenolide R10Repoxyparthenolide RRepoxyparthenolide R,10R epoxyparthenolide R 10R IR (IR VCD (VCD B3PW91/6311G. B3PW916311G BPWG B3PW91/6 311G. B3PW91 6 311G B PW G B3PW91/6-311G Furthermore time IC50 IC (IC50 parasites diseases (L P45 45 P-4 20tetrakispentafluorophenylporphyrin 5101520 5,10,15,2 2 10Repoxyparthenolide Repoxyparthenolide R10R RR 6311G B3PW91/6311G B3PW916 BPW B3PW91/ B3PW9 IC5 (IC5 P4 4 P- 510152 5,10,15, B3PW (IC 51015 5,10,15 5101 5,10,1 510 5,10, 51 5,10 5,1 5,

The study of atomic spectroscopy has a profound relationship with quantum mechanics and its comprehension. Since Bohr’s success with a theory for the atom, it has been established that spectrum lines originate from transitions between different states. Moreover, the analysis of complex spectra reveals that there are groups of spectral lines that compose what is called a multiplet. To rationalize the multiplet structure, we need models to characterize and label the quantum states. The characterization of the atomic states is a common subject in classes of physical chemistry and inorganic chemistry, and there are basically two approaches to infer and label the energy states: (i) the LS coupling scheme and (ii) the jj coupling scheme. Usually, only the LS coupling is presented, and this ends up omitting its underlying assumptions. Here, we present a survey of both approaches, highlighting their premises and their adequacy towards different groups of the periodic table, ions, and excited states configurations. We show that by using benchmark data together with the Landé interval rule, the appropriate use of the jj coupling to understand the atomic spectra of heavier atoms is easily conveyed. comprehension Bohrs Bohr s atom Moreover structure i (i ii (ii Usually presented assumptions Here table ions configurations rule conveyed

Diaporthe phaseolorum, an endophyte isolated from Combretum lanceolatum, has exhibited diverse biological activities including antimicrobial, leishmanicidal, antitumoral, and herbicidal properties. Regardless of these activities, there remains limited research on its chemical constituents. Therefore, this study aimed to investigate the metabolome of D. phaseolorum employing mass spectrometry data dereplication through molecular networking and MolNetEnhancer tools. Twenty two molecular families were annotated, including prenol lipids, benzenoids, organoheterocyclic compounds, and nucleosides. Among the 41 nodes annotated, 36 metabolites were confirmed via spectral references, including alismol, farnesol, linoleic acid, tyramine, N-acetyl-tyramine, 5-methoxy-1H-indole-3-carbaldehyde, 6-pentyl-2H-pyran-2-one, and adenosine. Further node annotation was achieved through MolNetEnhancer, resulting in the classification of an additional 68 nodes into various molecular families. Consequently, this study represents a significant contribution to the identification of the D. phaseolorum metabolome, highlighting its secondary metabolites and providing valuable chemical insights to elucidate its demonstrated biological activities. lanceolatum antimicrobial leishmanicidal antitumoral properties constituents Therefore D tools annotated lipids benzenoids compounds nucleosides 4 3 references alismol farnesol acid tyramine Nacetyltyramine, Nacetyltyramine N acetyl N-acetyl-tyramine 5methoxy1Hindole3carbaldehyde, 5methoxy1Hindole3carbaldehyde methoxyHindolecarbaldehyde 5 methoxy 1H indole carbaldehyde, carbaldehyde H 5-methoxy-1H-indole-3-carbaldehyde 6pentyl2Hpyran2one, 6pentyl2Hpyran2one pentylHpyranone 6 pentyl 2H pyran 2 one, one 6-pentyl-2H-pyran-2-one adenosine Consequently Hindole Hpyran

RESUMO Objetivo: Avaliar a sazonalidade da bronquiolite aguda no Brasil durante a temporada 2020–2022 e compará-la com a das temporadas anteriores. Métodos: Os dados de incidência de internações por bronquiolite aguda em lactentes <1 ano de idade foram obtidos do Departamento de Informática da base de dados da Saúde Pública Brasileira para o período entre 2016 e 2022. Esses dados também foram analisados por macrorregiões do Brasil (Norte, Nordeste, Sudeste, Sul e Centro-Oeste). Para descrever características sazonais e de tendência ao longo do tempo, utilizamos o Modelo de Médias Móveis Integradas Autorregressivas Sazonais. Resultados: Em comparação com o período pré-COVID-19, a incidência de hospitalizações relacionadas com bronquiolite aguda diminuiu 97% durante as intervenções não farmacológicas (março de 2020 – agosto de 2021), mas aumentou 95% após a flexibilização das intervenções não farmacológicas (setembro de 2021 – dezembro de 2022), resultando no aumento geral de 16%. Durante o período pré-COVID-19, as hospitalizações por bronquiolite aguda seguiram um padrão sazonal, que foi interrompido em 2020–2021, mas recuperaram-se em 2022, com um pico ocorrido em maio, aproximadamente 4% superior ao pico pré-COVID-19. Conclusões: Este estudo ressalta a influência significativa das intervenções contra a COVID-19 nas hospitalizações por bronquiolite aguda no Brasil. A restauração de um padrão sazonal em 2022 sublinha a interação entre as medidas de saúde pública e a dinâmica das doenças respiratórias em crianças pequenas. Objetivo 20202022 2020–202 comparála compará la anteriores Métodos 1 < 201 Norte, Norte (Norte Nordeste Sudeste CentroOeste. CentroOeste Centro Oeste . Centro-Oeste) tempo Sazonais Resultados préCOVID19, préCOVID19 préCOVID pré COVID 19, 19 pré-COVID-19 97 março 202 2021, , 2021) 95 setembro 2022) 16 16% 20202021 2020–2021 recuperaramse recuperaram se maio 4 préCOVID19. 19. Conclusões COVID19 COVID-1 pequenas 2020202 2020–20 20 Centro-Oeste préCOVID1 pré-COVID-1 9 COVID1 COVID- 202020 2020–2 2 pré-COVID- 20202 2020– pré-COVID

ABSTRACT Objective: To evaluate the seasonality of acute bronchiolitis in Brazil during the 2020–2022 season and compare it with the previous seasons. Methods: Data from the incidence of hospitalizations due to acute bronchiolitis in infants <1 year of age were obtained from the Department of Informatics of the Brazilian Public Health database for the period between 2016 and 2022. These data were also analyzed by macro-regions of Brazil (North, Northeast, Southeast, South, and Midwest). To describe seasonal and trend characteristics over time, we used the Seasonal Autoregressive Integrated Moving Averages Model. Results: Compared to the pre-COVID-19 period, the incidence of hospitalizations related to acute bronchiolitis decreased by 97% during non-pharmacological interventions (March 2020 – August 2021) but increased by 95% after non-pharmacological interventions relaxation (September 2021 – December 2022), resulting in a 16% overall increase. During the pre-COVID-19 period, hospitalizations for acute bronchiolitis followed a seasonal pattern, which was disrupted in 2020–2021 but recovered in 2022, with a peak occurring in May, approximately 4% higher than the pre-COVID-19 peak. Conclusions: This study underscores the significant influence of COVID-19 interventions on acute bronchiolitis hospitalizations in Brazil. The restoration of a seasonal pattern in 2022 highlights the interplay between public health measures and respiratory illness dynamics in young children. Objective 20202022 2020–202 seasons Methods 1 < 201 macroregions macro regions North, North (North Northeast Southeast South Midwest. Midwest . Midwest) time Model Results preCOVID19 preCOVID pre COVID 19 pre-COVID-1 97 nonpharmacological non pharmacological March 202 95 September , 2022) 16 increase 20202021 May 4 Conclusions COVID19 COVID-1 children 2020202 2020–20 20 preCOVID1 pre-COVID- 9 COVID1 COVID- 202020 2020–2 2 pre-COVID 20202 2020–

ABSTRACT Planting is considered one of the most essential steps in coffee growing. Lack of uniformity in planting may compromise future operations. Therefore, verifying planting operations quality is fundamental to optimizing production processes and reducing costs. This study aimed to investigate planting techniques through Statistical Process Control (SPC) and aerial images. Carried out in two areas, managed manually and semi-mechanized in the Bom Jardim Farm (MG - Brazil). Data were collected through Remotely Piloted Aircraft (RPA). Quality control charts and density maps were used to identify variations in distribution and spacing between plants and planting rows. It was found that the planting carried out manually was 4.7% wider than projected due to spacing reduction from 0.5 m to 0.48 m. The semi-mechanized system displayed a deficit of 7% compared to the projected planting system, using 0.55 m between plants. The density map showed the most significant planting alignment variations. Despite displaying lower results than the manual system, the semi-mechanized system improvements are valid for their minimal average variations. Thus, correcting points found outside the limits can increase the efficiency of semi-mechanized planting. growing Therefore costs SPC (SPC images areas semimechanized semi mechanized MG Brazil. Brazil . Brazil) RPA. RPA (RPA) rows 47 4 7 4.7 05 0 5 0. 048 48 0.4 055 55 Thus (RPA 4. 04