Abstract: This paper introduces the Distributed Utility Function Algorithm (D-AFU) as a notable progression in managing and optimizing network traffic within distributed settings. Based on the utility function principle, D-AFU dynamically adjusts data rate in response to ever-changing network demands, with optimal performance and a higher user experience. Contrary to the centralized model, D-AFU employs a distributed, scalable and resilient against failures and system overloads mechanism. Its efficiency was validated using the NS-3 simulator. Three main metrics were used: the data rate allocation, utility per session, and fairness (quantified by the Gini coefficient). D-AFU displays exceptional performance and low latency, particularly vital for real-time applications with high Quality of Service (QoS) requirements.

Resumen: El artículo presenta el Algoritmo de Función de Utilidad Distribuida (D-AFU) como una notable evolución en la gestión y optimización del tráfico de red en entornos distribuidos. Basado en el principio de función de utilidad, D-AFU ajusta dinámicamente la velocidad de datos en respuesta a las demandas cambiantes de la red, con un rendimiento óptimo y una mejor experiencia para el usuario. A diferencia del modelo centralizado, D-AFU emplea un mecanismo distribuido escalable y con mayor resistencia contra fallos y sobrecargas del sistema. Su eficiencia fue validada utilizando el simulador NS-3. Se utilizaron tres métricas principales: la tasa de asignación de transmisión, la utilidad por sesión y la equidad (cuantificada por el coeficiente de Gini). D-AFU mostró un rendimiento excepcional, especialmente vital para aplicaciones en tiempo real que exigen alta Calidad de Servicio (QoS) y baja latencia.

Abstract A 9-year-old gelding presented a corneal ulcer unresponsive to treatment in his right eye. The trauma was caused by vegetal material. The ophthalmologic exam revealed paraxial corneal opacity, whitish discharge, peripheral oedema, congestion of conjunctival vessels and corneal angiogenesis. Microscopic examination of smears revealed the presence of neutrophils and fungal hyphae. On day 3 of culture, several small white fluffy colonies that rapidly turned to pale green were detected. These colonies were isolated to study their micro and macromorphology. Microscopic examination revealed the presence of colourless, thick-walled, roughened conidiophores, ranging from 340 to 1650 µm in length, with globose to sub-globose vesicles, ranging from 22 to 48 µm in diameter. Vesicles had one or two series of phialides. Conidia were globose, olive-green with slightly rough, thin walls that ranged from 3 to 7 µm in diameter. Molecular identification was also performed. Both techniques confirmed the presence of Aspergillus flavus complex. Topical treatment with natamycin resulted in healing within 10 days. To our knowledge, this is the first case of equine keratomycosis reported in Argentina.

Resumen Un equino castrado de 9 años presentó una úlcera corneal en el ojo derecho, sin respuesta al tratamiento. El trauma fue causado por material vegetal. El examen oftalmológico reveló opacidad corneal paraxial cubierta por una descarga blanquecina y edema periférico, asociado a congestión de vasos conjuntivales y angiogénesis corneal. El examen microscópico reveló la presencia de neutrófilos e hifas fúngicas. Al tercer día de cultivo se detectaron varias colonias blancas que se tornaron de color verde pálido. El examen microscópico de estos aislamientos reveló la presencia de conidióforos incoloros, rugosos y de paredes gruesas, de entre 340 y 1650 µm de longitud, con vesículas globosas a subglobosas, de entre 22 y 48 µm de diámetro. Las vesículas tenían una o dos series de fiálides. Los conidios eran globosos, de color verde oliva con paredes delgadas y ligeramente rugosas que oscilaban entre 3 y 7 µm de diámetro. También se realizó la identificación molecular. Ambas técnicas confirmaron la presencia del complejo Aspergillus flavus. El uso tópico de natamicina resultó efectivo en la resolución de la lesión. Hasta donde sabemos, este es el primer caso de queratomicosis equina reportado en Argentina.

Abstract Contemporary transformations linked to technology, the world of work, unemployment, and the effects of the pandemic in Brazil have been altering territorial dynamics. However, such factors only added to the perverse stability of socio-spatial inequalities in Brazilian cities, particularly in São Paulo. By revealing the current social segregation in a city linked to the flows of global capitalism, the difficulties faced by many in the job and housing market bring scenarios of congestion and difficulties in accessing workplaces and the built environment. In addition to revealing the daily struggle of the majority due to inequality in opportunity and commuting, they indicate the important role of urban mobility, which may come to have a leading role as a public policy. technology work unemployment dynamics However sociospatial socio spatial cities Paulo capitalism environment commuting mobility policy

Resumo As transformações contemporâneas ligadas à tecnologia, ao mundo do trabalho, ao desemprego, e aos efeitos da pandemia de covid-19 no Brasil alteraram as dinâmicas territoriais. Entretanto, tais fatores apenas se acrescentaram à perversa estabilidade das desigualdades socioespaciais nas cidades brasileiras, em particular em São Paulo. As dificuldades de muitas pessoas de inserção no mercado de trabalho e de moradia, ao revelarem a segregação social vigente em uma cidade ligada aos fluxos do capitalismo global, trazem cenários de congestionamento e de dificuldades de acesso aos locais de trabalho e ao ambiente construído. Além de revelar a luta cotidiana majoritária devido à iniquidade das oportunidades e dos deslocamentos, indicam o importante papel da mobilidade urbana que pode vir a assumir protagonismo enquanto política pública. tecnologia desemprego covid19 covid 19 covid-1 territoriais Entretanto brasileiras Paulo moradia global construído deslocamentos pública covid1 1 covid-

Abstract Background: In Mexico, the epidemiology of heart failure is still not well understood. However, it is known that the primary cause of hospital admissions in patients with heart failure is pulmonary and systemic congestion. Objective: To estimate congestion status and assess cardiac function using portable ultrasound in patients with heart failure. Method: A cross-sectional observational study was conducted. Patients who attended the Heart Failure Clinic at the Ignacio Chávez National Cardiology Institute in Mexico City between May and August 2022 were selected. They underwent ultrasonographic evaluation using a portable device to assess pulmonary and systemic congestion, as well as cardiac function and structure. Results: One-hundred patients diagnosed with heart failure were prospectively included during the study period; 76% were male, with an average age of 59 years (range: 50-68 years). The recorded LVEF median was 34% (IQR: 27-43.5%). When evaluating pulmonary congestion, 78% of the patients showed a pattern A and 22% a pattern B. Following the VExUS protocol, 92% of the patients were at grade 0, 2% at grade 1, and 6% at grade 2. Conclusions: The use of the portable ultrasound facilitated the quantitative characterization of the echocardiographic features of the studied population. This device could provide better clinical characterization which, in turn, might allow for optimized drug prescription for heart failure and dose adjustments of diuretics based on echocardiographic congestion findings.

Resumen Antecedentes: En México aún es muy poco conocida la epidemiología de la insuficiencia cardiaca, sin embargo se sabe que la principal causa de ingresos hospitalarios en los pacientes con insuficiencia cardiaca es la congestión pulmonar y sistémica. Objetivo: Estimar el estado de congestión y evaluar la función cardiaca mediante el ultrasonido portátil en pacientes con insuficiencia cardiaca tratados en un centro de tercer nivel en México. Método: Se llevó a cabo un estudio observacional transversal. Se seleccionaron pacientes que acudieron a la Clínica de Insuficiencia Cardiaca del Instituto Nacional de Cardiología Ignacio Chávez en la Ciudad de México entre mayo y agosto de 2022. Se les sometió a una evaluación ultrasonográfica mediante un dispositivo portátil para valorar la congestión pulmonar y sistémica, así como la función y estructura cardiaca. Resultados: Se incluyeron de forma prospectiva 100 pacientes diagnosticados con insuficiencia cardiaca en el periodo de estudio. El 76% fueron hombres, con una edad mediana de 59 años (RIQ: 50-68 años). La mediana del FEVI registrada fue del 34% (RIQ: 27.0-43.5%). Al evaluar la congestión pulmonar, el 78% de los pacientes presentaron un patrón A y el 22% un patrón B. Siguiendo el protocolo VExUS, el 92% de los pacientes mostraron un grado 0, el 2% un grado 1 y el 6% un grado 2. Conclusiones: El uso del ultrasonido portátil facilitó la caracterización cuantitativa de las características ecocardiográficas de la población estudiada. Este dispositivo podría ofrecer una mejor caracterización clínica que, a su vez, permita una optimización en la prescripción de medicamentos para la insuficiencia cardiaca y el ajuste de dosis de diuréticos según los hallazgos ecocardiográficos de congestión.

Abstract 19. This study reports an episode of fish mortality occurred in the Garupá and Pindapoy Grande streams, near the confluence with the Paraná River (Garupá, Argentina). Dead and moribund fish of various species were observed floating on the water surface. Environmental parameters measured were temperature 5 °C, water temperature 15.1 (±0.6) °C, dissolved oxygen 8.7 (±1.2) ppm, pH 7.5 (±0.2), electrical conductivity 67.6 (± 8.8) mS cm-1 and mean depth of 1.7 (±1.0) m. Macroscopic examination of moribund fish revealed corneal opacity, whitish tegument, increased gill mucus, and whitish areas on gill filaments. Microscopic analysis of gills revealed severe generalized epithelial hyperplasia, lamellar fusion, congestion, and inflammatory infiltrate, particularly lymphocytes and eosinophilic granular cells. In addition, microscopic examination allowed the identification of the following ectoparasites found in gills and tegument: Chilodonella, Ichthyophthirius, Dactylogyridae and Trichodinidae, representing 98%, 1.2%, 0.6% and 0.2%, respectively. This study constitutes a novel record of wild fish mortality associated with extreme environmental conditions and parasitosis. Furthermore, our findings are significant as there are no prior reports in Argentina of epizootic cases linked to Chilodonella sp. infection in wild or farmed fish populations, being the first report of chilodonelliasis for this region.

Resumen 23. Este estudio reporta un episodio de mortandad de peces ocurrido en los arroyos Garupá y Pindapoy Grande, cerca de la confluencia con el río Paraná (Garupá, Argentina). En este tramo se encontraron flotando en la superficie del agua, peces moribundos y muertos de diferentes especies. Los parámetros medidos fueron: temperatura ambiental 5 °C, temperatura del agua 15,1 (±0,6) °C, oxígeno disuelto 8,7 (±1,2) ppm, 24. pH 7,5 (±0,2), conductividad 67,6 (± 8,8) mS cm-1 y profundidad media de 1,7 (±1,0) m. En el examen macroscópico de peces moribundos se observó opacidad corneal, tegumento blanquecino, aumento de moco branquial y áreas blanquecinas en los filamentos branquiales. El análisis microscópico de las branquias reveló hiperplasia epitelial generalizada grave, fusión laminar, congestión e infiltrado inflamatorio, particularmente linfocitos y células granulares eosinófilas. Además, el examen microscópico permitió identificar los siguientes ectoparásitos encontrados en piel y branquias: Chilodonella, Ichthyophthirius, Dactylogyridae y Trichodinidae, que representó el 98%; 1,2%; 0,6% y 0,2%, respectivamente. El presente estudio es un nuevo registro de mortandad de peces silvestres relacionada con condiciones ambientales extremas y parasitosis. Además, nuestro hallazgo aporta información valiosa, ya que en Argentina no existen registros de casos epizoóticos asociados a infección por Chilodonella sp. en poblaciones de peces silvestres o de criaderos, siendo el primer reporte de quilodonelliasis para esta región.

ABSTRACT Purpose: To investigate the effect of ellagic acid (EA) in gingival tissues injury in rats. Methods: Twenty rats were categorized into two groups. In burn group, an excisional wound area was created by removing a 4-mm diameter flap from the left molar region in the mucoperiosteal region of the gingiva. In burn + ellagic acid group, 1.2 mg/mL EA was administered as irrigation for one week. Animals was sacrificed under anesthesia at the end of experiment. Malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) level were measured. Hematoxylin and eosin, fibroblast growth factor (FGF) and epidermal growth factor (EGF) immunostainings were applied to tissues. Results: MDA, MPO, inflammation and leukocyte infiltration were high in burn group. Degeneration epithelium, edema and inflammatory cell infiltration in connective tissue areas, and dilatation and congestion in blood vessels were observed in burn group. In burn + EA group, the gingival epithelium improved, collagen fiber production increased and organized dermis were observed. After burn injury, FGF and EGF activity was increased in EA treated groups. Conclusions: We suggest that EA have the potential for better healing outcomes in oral wounds. EA seems to have promising therapeutic efficacy to enhance oral wound healing. Purpose (EA Methods groups group 4mm mm 4 gingiva 12 1 2 1. mgmL mg mL week experiment MDA , (MDA) MPO (MPO GSH (GSH measured eosin (FGF (EGF Results areas improved Conclusions wounds (MDA

Abstract Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis are rare types of histopathological substrates within the spectrum of pulmonary arterial hypertension (PAH) with a very poor prognosis. They are characterized by a widespread fibroproliferative process of the small caliber veins and/or capillaries with sparing of the larger veins, resulting in a pre-capillary pulmonary hypertension phenotype. Clinical presentation is unspecific and similar to other PAH etiologies. Definitive diagnosis is obtained through histological analysis, although lung biopsy is not advised due to a higher risk of complications. However, some additional findings may allow a presumptive clinical diagnosis of PVOD, particularly a history of smoking, chemotherapy drug use, exposure to organic solvents (particularly trichloroethylene), low diffusing capacity for carbon monoxide (DLCO), exercise induced desaturation, and evidence of venous congestion without left heart disease on imaging, manifested by a classical triad of ground glass opacities, septal lines, and lymphadenopathies. Lung transplant is the only effective treatment, and patients should be referred at the time of diagnosis due to the rapid progression of the disease and associated poor prognosis. We present a case of a 58-year-old man with PAH with features of venous/capillary involvement in which clinical suspicion, prompt diagnosis, and early referral for lung transplantation were determinant factors for the successful outcome. venoocclusive veno occlusive PVOD (PVOD (PAH prognosis andor or precapillary pre phenotype etiologies analysis complications However smoking use trichloroethylene, trichloroethylene , trichloroethylene) DLCO, DLCO (DLCO) desaturation imaging opacities lines lymphadenopathies treatment 58yearold yearold 58 year old venouscapillary suspicion outcome (DLCO 5

Resumo A doença veno-oclusiva pulmonar (DVOP) e a hemangiomatose capilar pulmonar são tipos raros de substratos histopatológicos dentro do espectro da hipertensão arterial pulmonar (HAP) com prognóstico muito ruim. Caracterizam-se por um processo fibroproliferativo generalizado das veias e/ou capilares de pequeno calibre com preservação das veias maiores, resultando em um fenótipo de hipertensão pulmonar pré-capilar. A apresentação clínica é inespecífica e semelhante a outras etiologias de HAP. O diagnóstico definitivo é obtido por meio de análise histológica, embora a biópsia pulmonar não seja aconselhada devido ao maior risco de complicações. No entanto, alguns achados adicionais podem permitir um diagnóstico clínico presuntivo de DVOP, especialmente história de tabagismo, uso de drogas quimioterápicas, exposição a solventes orgânicos (particularmente tricloroetileno), baixa capacidade de difusão do monóxido de carbono (DLCO), dessaturação ao esforço e evidências de doença venosa sem doença cardíaca esquerda no exame de imagem, manifestada por uma tríade clássica de opacidades em vidro fosco, linhas septais, e linfadenopatias. O transplante pulmonar é o único tratamento eficaz e os pacientes devem ser encaminhados no momento do diagnóstico, devido à rápida progressão da doença e ao prognóstico ruim. Apresentamos o caso de um homem de 58 anos com HAP com características de envolvimento venoso/capilar em que a suspeita clínica, o pronto diagnóstico e o encaminhamento precoce para transplante pulmonar foram determinantes para um bom desfecho. venooclusiva veno oclusiva DVOP (DVOP (HAP ruim Caracterizamse Caracterizam se eou ou maiores précapilar. précapilar pré capilar. pré-capilar histológica complicações entanto tabagismo quimioterápicas particularmente tricloroetileno, tricloroetileno , tricloroetileno) DLCO, DLCO (DLCO) imagem fosco septais linfadenopatias 5 venosocapilar venoso desfecho (DLCO

ABSTRACT Objective: This study aimed to describe the clinical characteristics of the pediatric population with COVID-19 in an Emergency Department (ED) of a Brazilian general hospital. Methods: Epidemiological and clinical data of patients younger than 20 years old were collected from patients’ medical records from February 2020 to July 2021. Most of the epidemiological data described pertains to hospitalized patients. We also reviewed coinfections, treatment, and outcomes and compared the first and second waves of COVID-19. Results: We identified a total of 1303 episodes of SARS-CoV-2 infection. The median time from symptom onset to diagnosis was three days. Symptoms were present in 92.3% of the patients. The most common symptoms were fever (45.2%), nasal congestion/discharge (44.2%), and cough (39.4%). Chest radiography and tomography were performed in 7.7 and 3.3% of cases, with abnormal findings in 29.7 and 53.4%, respectively. Hospital admissions occurred in 3.5% of patients, mainly in the presence of comorbidities, in children under five years old and in those who presented to the ED during the first wave of COVID-19. Coinfection with a viral agent was identified in 20% of the 71 cases tested in this study, and a positive rapid test for Streptococcus pyogenes was found in 8% of the 174 cases tested, with no impact of these coinfections on hospitalization. Conclusions: We found that COVID-19 was a mild disease in most children in our study population, with most hospitalizations and readmissions occurring during the first wave of COVID-19. Objective COVID19 COVID 19 COVID-1 (ED hospital Methods 2 202 2021 treatment COVID19. 19. Results 130 SARSCoV2 SARSCoV SARS CoV SARS-CoV- infection days 923 92 3 92.3 45.2%, 452 45.2% , 45 (45.2%) congestiondischarge congestion discharge 44.2%, 442 44.2% 44 (44.2%) 39.4%. 394 39.4% . 39 4 (39.4%) 77 7 7. 33 3.3 297 29 29. 534 53 53.4% respectively 35 5 3.5 comorbidities 8 17 hospitalization Conclusions COVID1 1 COVID- 13 SARS-CoV 9 92. 45.2 (45.2% 44.2 (44.2% 39.4 (39.4% 3. 53.4 45. (45.2 44. (44.2 39. (39.4 53. (45. (44. (39. (45 (44 (39 (4 (3 (

RESUMO Objetivo: Este estudo teve como objetivo descrever as características clínicas da população pediátrica com COVID-19 no setor de emergência de um hospital geral brasileiro. Métodos: Os dados epidemiológicos e clínicos de pacientes idade inferior a 20 anos foram coletados dos prontuários dos pacientes de fevereiro de 2020 a julho de 2021. A maior parte dos dados epidemiológicos descritos refere-se a pacientes hospitalizados. Também foram revisados as coinfecções, o tratamento e os desfechos de internação e comparadas a primeira e a segunda ondas de COVID-19. Resultados: Foi identificado o total de 1.303 episódios de infecção por SARS-CoV-2. A mediana de tempo desde o início dos sintomas até o diagnóstico foi de três dias. Os sintomas estiveram presentes em 92,3% dos pacientes. Os sintomas mais comuns foram febre (45,2%), congestão/secreção nasal (44,2%) e tosse (39,4%). Radiografia e tomografia de tórax foram realizadas em 7,7 e 3,3% dos casos, com achados anormais em 29,7 e 53,4%, respectivamente. As internações hospitalares ocorreram em 3,5% dos pacientes, principalmente na presença de comorbidades, em crianças menores de cinco anos e naqueles que se apresentaram no pronto-socorro durante a primeira onda de COVID-19. Foi identificada coinfecção viral em 20% dos 71 casos testados e teste rápido positivo para Streptococcus pyogenes em 8% dos 174 casos testados, não havendo impacto dessas coinfecções quanto à internação hospitalar. Conclusões: Observamos que a COVID-19 foi uma doença leve na maioria das crianças de nossa população, com a maior parte das hospitalizações e readmissões ocorrendo durante a primeira onda de COVID-19. Objetivo COVID19 COVID 19 COVID-1 brasileiro Métodos 2 202 2021 referese refere hospitalizados COVID19. 19. Resultados 1303 1 303 1.30 SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. SARS-CoV-2 dias 923 92 3 92,3 45,2%, 452 45,2% , 45 (45,2%) congestãosecreção congestão secreção 44,2% 442 44 (44,2% 39,4%. 394 39,4% . 39 4 (39,4%) 77 7 7, 33 3,3 297 29 29, 534 53 53,4% respectivamente 35 5 3,5 comorbidades prontosocorro pronto socorro 8 17 hospitalar Conclusões COVID1 COVID- 130 30 1.3 SARS-CoV- 9 92, 45,2 (45,2% 44,2 (44,2 39,4 (39,4% 3, 53,4 13 1. SARS-CoV 45, (45,2 44, (44, 39, (39,4 53, (45, (44 (39, (45 (4 (39 ( (3

ABSTRACT Objective: To verify the COVID-19 clinical characteristics, associated comorbidities, and outcomes in adolescents. Data source: This is a systematic review study based on articles published between 2020 and 2022 in the United States National Library of Medicine - PubMed (MedLine), Virtual Health Library – VHL (LILACS), Science Direct, Web of Science, and Scopus (Elsevier) databases. The study was registered in the International Prospective Register of Systematic Reviews, under No. CRD42022309108. Data synthesis: A total of 1188 studies were identified. After applying the selection criteria, 13 articles were included. Prevalence was 25%; mild cases were predominant; and fever, cough, headache, anosmia, nasal congestion, and ageusia were frequent. Fever and cough were proportionally higher in hospitalized cases: 81 and 68%, respectively. Dyspnea (odds ratio [OR] 6.3; confidence interval 95%[CI] 2.8–14.3), fever (OR 3.8; 95%CI 2.0–7.4), and cough (OR 3.4; 95%CI 2.0–6.0) were associated with severe cases. Up to 28% required intensive care and 38% required mechanical ventilation. Pre-existing comorbidities increased the risk of hospitalization and death. Severe cases were associated with the risk of death (relative risk [RR] 4.6; 95%CI 2.8–7.5). The black, mixed, and indigenous races/skin colors represented risk groups, as well as residents of poorer regions. Conclusions: The review provided a better understanding of the disease profile and may favor the development of public policies, in addition to contributing to the current literature in the field of adolescent health. Objective COVID19 COVID 19 COVID-1 characteristics adolescents source 202 MedLine, MedLine , (MedLine) LILACS, LILACS (LILACS) Direct Elsevier (Elsevier databases Reviews No CRD42022309108 CRD synthesis 118 identified criteria 1 included 25% 25 predominant headache anosmia congestion frequent 8 68 68% respectively odds OR [OR 6.3 63 6 3 95CI CI 95% 95 95%[CI 2.8–14.3, 28143 2.8–14.3 2 14 2.8–14.3) 3.8 38 2.0–7.4, 2074 2.0–7.4 0 7 4 2.0–7.4) 3.4 34 2.0–6.0 2060 28 ventilation Preexisting Pre existing relative RR [RR 4.6 46 2.8–7.5. 2875 2.8–7.5 . 5 2.8–7.5) black mixed racesskin races skin groups regions Conclusions policies health COVID1 COVID- 20 (MedLine (LILACS CRD4202230910 11 6. 9 2814 2.8–14. 3. 207 2.0–7. 2.0–6. 206 4. 287 2.8–7. CRD420223091 281 2.8–14 2.0–7 2.0–6 2.8–7 CRD42022309 2.8–1 2.0– 2.8– CRD4202230 2.0 2.8 CRD420223 2. CRD42022 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Verificar as características clínicas, as comorbidades associadas e os desfechos da COVID-19 em adolescentes. Fontes de dados: Trata-se de uma revisão sistemática elaborada com base em artigos publicados entre 2020 e 2022 nas bases de dados United States National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS), Science Direct, Web of Science e Scopus. O estudo foi registrado no International Prospective Register of Systematic Reviews, n° CRD42022309108. Síntese dos dados: Foram identificados 1.188 estudos. Após a aplicação dos critérios de seleção, 13 artigos foram incluídos. A prevalência foi de 25%; os casos leves foram predominantes; e febre, tosse, cefaleia, anosmia, congestão nasal e ageusia foram frequentes. Febre e tosse foram proporcionalmente maiores em casos hospitalizados, com 81 e 68%, respectivamente. Dispneia (OR 6,3; IC95% 2,8–14,3), febre (OR 3,8; IC95% 2,0–7,4) e tosse (OR 3,4; IC95% 2,0–6,0) foram associados a casos graves. Até 28% necessitaram de cuidados intensivos e 38% de ventilação mecânica. A preexistência de comorbidade aumentou o risco de internação e óbito. Os casos graves estão associados ao risco de óbito (risco relativo — RR 4,6; IC95% 2,8–7,5). As raças/cores preta, parda e indígena e os moradores de regiões mais pobres foram grupo de risco. Conclusões: A revisão permitiu conhecer o perfil da doença e poderá favorecer a elaboração de políticas públicas, além de contribuir para a literatura atual no campo da saúde do adolescente. Objetivo clínicas COVID19 COVID 19 COVID-1 adolescentes Tratase Trata se 202 PubMed, PubMed , (PubMed) BVS, BVS (BVS) Direct Scopus Reviews n CRD42022309108 CRD 1188 1 188 1.18 estudos seleção incluídos 25% 25 predominantes cefaleia anosmia frequentes hospitalizados 8 68 68% respectivamente OR 6,3 63 6 3 IC95 IC 2,8–14,3, 28143 2,8–14,3 2 14 2,8–14,3) 3,8 38 2,0–7,4 2074 0 7 4 3,4 34 2,0–6,0 2060 28 mecânica 4,6 46 2,8–7,5. 2875 2,8–7,5 . 5 2,8–7,5) raçascores raças cores preta Conclusões públicas adolescente COVID1 COVID- 20 (PubMed (BVS CRD4202230910 118 18 1.1 6, IC9 2814 2,8–14, 3, 2,0–7, 207 2,0–6, 206 4, 287 2,8–7, CRD420223091 11 1. 281 2,8–14 2,0–7 2,0–6 2,8–7 CRD42022309 2,8–1 2,0– 2,8– CRD4202230 2,0 2,8 CRD420223 2, CRD42022 CRD4202 CRD420 CRD42 CRD4

Abstract Background Residual venous congestion is a major contributor to readmission of patients with heart failure, and the venous excess ultrasound (VExUS) score is a potentially useful tool to evaluate systemic congestion. Objectives To investigate the association between VExUS score before hospital discharge among patients with heart failure and the risk of readmission due to acute decompensated heart failure (ADHF) within 90 days after discharge. Methods This prospective cohort study enrolled adults with signs and symptoms of ADHF, left ventricular ejection fraction of 40% or below (heart failure with reduced ejection fraction), New York Heart Association functional class II to IV symptoms, and clinical evidence of venous congestion necessitating intravenous diuretics. Just prior to discharge, we conducted VExUS score evaluation. The primary outcome was a composite endpoint of readmission or emergency visits due to ADHF within 90 days following hospital discharge. Statistical significance was set at p < 0.05. Results The cohort comprised 49 individuals, 11 (22.4%) of whom experienced the primary outcome. At discharge, 34.7% of participants had VExUS score 2 or 3. Patients with VExUS 2 and 3 had a higher proportion of the primary outcome when compared with patients with VExUS of 0 (35.3% versus 9%, p = 0.044). Conclusions A significant proportion of patients with heart failure with reduced ejection fraction admitted for ADHF presented clinical and ultrasound signs of residual congestion at discharge. Patients with VExUS score of 2 or 3 at the time of hospital discharge were found to be at higher risk of readmissions or emergency visits due to ADHF after 90 days. (VExUS (ADHF 9 40 fraction, , fraction) diuretics evaluation 005 05 0.05 4 individuals 1 22.4% 224 22 (22.4% 347 34 7 34.7 35.3% 353 35 (35.3 9% 0.044. 0044 0.044 . 044 0.044) 00 0.0 22.4 (22.4 34. 35.3 (35. 004 0.04 04 0. 22. (22. 35. (35 (22 (3 (2 (

Resumo Fundamento A congestão venosa residual é um dos principais contribuintes para a readmissão de pacientes com insuficiência cardíaca, e o escore de ultrassonografia de excesso venoso (VExUS) é uma ferramenta potencialmente útil para avaliar a congestão sistêmica. Objetivos O objetivo do presente estudo foi investigar a associação entre o escore VExUS antes da alta hospitalar em pacientes com insuficiência cardíaca e o risco de readmissão por insuficiência cardíaca agudamente descompensada (ICAD) em até 90 dias após a alta. Métodos O presente estudo de coorte prospectivo envolveu adultos com sinais e sintomas de ICAD, fração de ejeção do ventrículo esquerdo de 40% ou menos (insuficiência cardíaca com fração de ejeção reduzida), sintomas de classe funcional II a IV da New York Heart Association e evidência clínica de congestão venosa necessitando de diuréticos intravenosos. Momentos antes da alta, realizamos avaliação do escore VExUS. O desfecho primário foi um desfecho composto de readmissão ou visitas de emergência devido à ICAD dentro de 90 dias após a alta hospitalar. A significância estatística foi estabelecida em p < 0,05. Resultados A coorte foi composta por 49 indivíduos, dos quais 11 (22,4%) apresentaram o desfecho primário. Na alta, 34,7% dos participantes tiveram escore VExUS de 2 ou 3. Os pacientes com VExUS de 2 e 3 tiveram maior proporção do desfecho primário quando comparados aos pacientes com VExUS de 0 (35,3% versus 9%, p = 0,044). Conclusões Uma proporção significativa de pacientes com insuficiência cardíaca com fração de ejeção reduzida admitidos por ICAD apresentou sinais clínicos e ultrassonográficos de congestão residual na alta. Pacientes com escore VExUS de 2 ou 3 no momento da alta hospitalar apresentaram maior risco de readmissões ou visitas de emergência por ICAD após 90 dias. (VExUS sistêmica (ICAD 9 40 reduzida, , reduzida) intravenosos 005 05 0,05 4 indivíduos 1 22,4% 224 22 (22,4% 347 34 7 34,7 35,3% 353 35 (35,3 9% 0,044. 0044 0,044 . 044 0,044) 00 0,0 22,4 (22,4 34, 35,3 (35, 004 0,04 04 0, 22, (22, 35, (35 (22 (3 (2 (

Resumo Fundamento: A insuficiência cardíaca (IC) é responsável por alta carga de internações hospitalares. A sua forma de apresentação está relacionada ao prognóstico da doença. Objetivos: Descrever a associação entre o perfil hemodinâmico de admissão hospitalar na IC aguda, baseado em congestão (úmido ou seco) e perfusão (frio ou quente), e desfechos de mortalidade, tempo de internação e chance de reinternação. Métodos: Estudo de coorte, envolvendo pacientes do projeto "Boas Práticas Clínicas em Cardiologia", internados por IC aguda em hospitais públicos brasileiros, entre março de 2016 a dezembro de 2019, com seguimento de seis meses. Foram realizadas análises das características populacionais e do perfil hemodinâmico de admissão, além de análises de sobrevivência pelos modelos de Cox para associação entre o perfil de admissão e mortalidade, e regressão logística para chance de reinternação, considerando nível de significância estatística de 5%. Resultados: Foram avaliados 1978 pacientes, com idade média foi 60,2 (±14,8) anos e fração de ejeção média do ventrículo esquerdo de 39,8% (±17,3%). Houve altas taxas de mortalidade no seguimento de seis meses (22%), com associação entre os perfis hemodinâmicos frios e a mortalidade hospitalar (HR=1,72; IC95% 1,27-2,31; p < 0,001) e em 6 meses (HR= 1,61, IC 95% 1,29-2,02). A taxa de reinternação em 6 meses foi de 22%, sendo maior para os pacientes admitidos em perfis úmidos (OR 2,30; IC95% 1,45-3,65; p < 0,001). Conclusões: A IC aguda no Brasil apresenta altas taxas de mortalidade e reinternações e os perfis hemodinâmicos de admissão hospitalar são bons marcadores prognósticos dessa evolução. Fundamento (IC hospitalares doença Objetivos úmido seco frio quente, quente , quente) Métodos coorte Boas Cardiologia, Cardiologia Cardiologia" brasileiros 201 2019 5 5% Resultados 197 602 60 2 60, ±14,8 148 14 8 (±14,8 398 39 39,8 ±17,3%. 173 ±17,3% . 17 3 (±17,3%) 22 22% (22%) HR=1,72 HR172 HR 1 72 (HR=1,72 IC95 1,272,31 127231 1,27 2,31 27 31 1,27-2,31 0,001 0001 0 001 HR= (HR 161 61 1,61 95 1,292,02. 129202 1,29 2,02 29 02 1,29-2,02) OR 2,30 230 30 1,453,65 145365 1,45 3,65 45 65 1,45-3,65 0,001. Conclusões evolução 20 19 ±14, (±14, 39, ±17,3 (±17,3% (22% HR=1,7 HR17 7 (HR=1,7 IC9 272 1,272,3 12723 127 1,2 231 2,3 1,27-2,3 0,00 000 00 16 1,6 9 292 1,292,02 12920 129 202 2,0 1,29-2,02 23 453 1,453,6 14536 145 1,4 365 3,6 4 1,45-3,6 ±14 (±14 ±17, (±17,3 (22 HR=1, HR1 (HR=1, 1,272, 1272 12 1, 2, 1,27-2, 0,0 1,292,0 1292 1,29-2,0 1,453, 1453 36 3, 1,45-3, ±1 (±1 ±17 (±17, (2 HR=1 (HR=1 1,272 1,27-2 0, 1,292, 1,29-2, 1,453 1,45-3 ± (± (±17 ( 1,27- 1,292 1,29-2 1,45- 1,29-

Abstract Background: Heart failure (HF) contributes to a high burden of hospitalization, and its form of presentation is associated with disease prognosis. Objectives: To describe the association of hemodynamic profile of acute HF patients at hospital admission, based on congestion (wet/dry) and perfusion (cold/warm), with mortality, hospital length of stay and risk of readmission. Methods: Cohort study, with patients participating in the "Best Practice in Cardiology" program, admitted for acute HF in Brazilian public hospitals between March 2016 and December 2019, with a six-month follow-up. Characteristics of the population and hemodynamic profile at admission were analyzed, in addition to survival analysis using Cox proportional hazard model for associations between hemodynamic profile at admission and mortality, and logistic regression for the risk of rehospitalization, using a statistical significance level of 5%. Results: A total of 1,978 patients were assessed, with mean age of 60.2 (±14.8) years and mean left ventricular ejection fraction of 39.8% (±17.3%). A high six-month mortality rate (22%) was observed, with an association of cold hemodynamic profiles with in-hospital mortality (HR=1.72, 95%CI 1.27-2.31; p < 0.001) and six-month mortality (HR= 1.61, 95%CI 1.29-2.02). Six-month rehospitalization rate was 22%, and higher among patients with wet profiles (OR 2.30; 95%CI 1.45-3.65; p < 0.001). Conclusions: Acute HF is associated with high mortality and rehospitalization rates. Patient hemodynamic profile at admission is a good prognostic marker of this condition. Background (HF hospitalization prognosis Objectives wet/dry wetdry dry (wet/dry cold/warm, coldwarm cold/warm , warm (cold/warm) readmission Methods study Best Cardiology program 201 2019 sixmonth six month followup. followup follow up. up follow-up analyzed 5 5% Results 1978 1 978 1,97 assessed 602 60 2 60. ±14.8 148 14 8 (±14.8 398 39 39.8 ±17.3%. 173 ±17.3% . 17 3 (±17.3%) 22% 22 (22% observed inhospital HR=1.72, HR172 HR 72 (HR=1.72 95CI CI 95 1.272.31 127231 1.27 2.31 27 31 1.27-2.31 0.001 0001 0 001 HR= (HR 161 61 1.61 1.292.02. 129202 1.29 2.02 29 02 1.29-2.02) Sixmonth Six OR 2.30 230 30 1.453.65 145365 1.45 3.65 45 65 1.45-3.65 0.001. Conclusions rates condition (cold/warm 20 197 97 1,9 6 ±14. (±14. 39. ±17.3 (±17.3% (22 HR=1.72 HR17 7 (HR=1.7 9 272 1.272.3 12723 127 1.2 231 2.3 1.27-2.3 0.00 000 00 16 1.6 292 1.292.02 12920 129 202 2.0 1.29-2.02 23 453 1.453.6 14536 145 1.4 365 3.6 4 1.45-3.6 19 1, ±14 (±14 ±17. (±17.3 (2 HR=1.7 HR1 (HR=1. 1.272. 1272 12 1. 2. 1.27-2. 0.0 1.292.0 1292 1.29-2.0 1.453. 1453 36 3. 1.45-3. ±1 (±1 ±17 (±17. ( HR=1. (HR=1 1.272 1.27-2 0. 1.292. 1.29-2. 1.453 1.45-3 ± (± (±17 HR=1 1.27- 1.292 1.29-2 1.45- 1.29-

ABSTRACT: The clinical, epidemiological and anatomopathological findings of anthelmintic poisoning in small ruminants diagnosed at the Veterinary Hospital of the Federal University of Campina Grande, Patos, Paraíba, from January 2000 to December 2022 are described. A total of 1,928 necropsies were carried out on small ruminants, of which 1,032 were goats and 896 sheep. Four outbreaks of anthelmintic poisoning were identified in these species: one outbreak of ivermectin in sheep, one outbreak of disophenol in goats and sheep and two outbreaks of nitroxinil in goats. These intoxications accounted for 0.78% and 0.23% of goat and sheep diseases diagnosed routinely. In the case of ivermectin poisoning, the animal had neurological clinical signs, and no macroscopic or histopathological alterations were observed. In the outbreaks of disophenol and nitroxinil, the animals showed anorexia, hyperthermia, tachycardia, tremors, dyspnea, incoordination and limb rigidity. Macroscopically, there were liver and kidney lesions associated with circulatory alterations, such as hemorrhages and edema. Microscopically, necrosis and degeneration of hepatocytes and tubular epithelial cells associated with hemorrhage and congestion were observed. The prevalence of these intoxications in small ruminants is considered low in the Semi-arid Northeast, but outbreaks can occur with high lethality in herds. The main risk factor for the occurrence of intoxications was overdose, combined with other factors such as the age of the animals, high environmental temperature, constant exercise and low body score, which increased the toxicity of anthelmintics. ABSTRACT Grande Patos Paraíba 200 202 described 1928 1 928 1,92 1032 032 1,03 89 species 078 0 78 0.78 023 23 0.23 routinely signs observed anorexia hyperthermia tachycardia tremors dyspnea rigidity Macroscopically edema Microscopically Semiarid Semi arid Northeast herds overdose temperature score anthelmintics 20 192 92 1,9 103 03 1,0 8 07 7 0.7 02 2 0.2 19 9 1, 10 0.

RESUMO: Descrevem-se os achados clínicos, epidemiológicos e anatomopatológicos das intoxicações por anti-helmínticos em pequenos ruminantes diagnosticadas no Hospital Veterinário da Universidade Federal de Campina Grande, Patos, Paraíba, durante o período de janeiro de 2000 a dezembro de 2022. Foram realizadas 1.928 necropsias de pequenos ruminantes, sendo 1.032 caprinos e 896 ovinos. Destes, foram identificados quatro surtos de intoxicação por anti-helmínticos nessas espécies: um surto de intoxicação por ivermectina em ovino, um surto de disofenol em caprinos e ovinos e dois surtos por nitroxinil em caprinos. Essas intoxicações representaram 0,78% e 0,23% das doenças de caprinos e ovinos diagnosticadas na rotina, respectivamente. Na intoxicação por ivermectina o animal apresentava sinais clínicos neurológicos e não foram observadas alterações macroscópicas e histopatológicas. Nos surtos de disofenol e nitroxinil, os animais demonstravam anorexia, hipertermia, taquicardia, tremores, dispneia, incoordenação e rigidez de membros. Macroscopicamente observou-se lesões hepáticas e renais associadas a alterações circulatórias como hemorragias e edemas. Microscopicamente observou-se necrose e degeneração de hepatócitos e das células epiteliais tubulares associadas a hemorragia e congestão. A prevalência dessas intoxicações em pequenos ruminantes é considerada baixa no Semiárido nordestino, entretanto, os surtos podem ocorrer com alta letalidade nos rebanhos. O principal fator de risco para a ocorrência das intoxicações foi a sobredosagem aliada aos demais fatores como idade dos animais, temperatura ambiental alta, exercício constante e escore corporal baixo, que provocaram o aumento da toxicidade dos anti-helmínticos. RESUMO Descrevemse Descrevem se antihelmínticos anti helmínticos Grande Patos Paraíba 200 2022 1928 1 928 1.92 1032 032 1.03 89 Destes espécies ovino 078 0 78 0,78 023 23 0,23 rotina respectivamente histopatológicas anorexia hipertermia taquicardia tremores dispneia membros observouse observou edemas congestão nordestino entretanto rebanhos baixo antihelmínticos. helmínticos. 20 202 192 92 1.9 103 03 1.0 8 07 7 0,7 02 2 0,2 19 9 1. 10 0,

Abstract The objective of the current study was to carry out a survey of the main anatomopathological alterations in raising quails and evaluate possible interference of these in the bone tissue. To obtain the data, 23 quails were collected from farm in the central Serrana region of Espírito Santo. Necropsies with macroscopic descriptions, microbiological, coproparasitological, radiographic and histomorphometric tests were carried out. It was done data descriptive analysis and average comparision using Student T test. It was found that they presented lesions predominantly in the digestive system, followed by urinary and reproductive, and muscular system, were the altered color of the liver (47%) was the most frequent lesion. In the parasitological exams, it was found oocysts of Eimeira sp. (39.13%). In the microbiological exams, it was detected predominantly Escherichia coli (83%). Moderate osteopenia in quails, but the percentage of trabecular bone on bones was similar between healthy and diseased quails, without bone changes in histology. Microscopically, it was observed lung congestion as predominant lesion. It is concluded that there was predominance of alterations in the digestive system and mild parasitic infection; and although there was moderate level of osteopenia, there wasn’t bone change as a result of the observed infections. tissue 2 Santo descriptions coproparasitological test reproductive 47% 47 (47% lesion exams sp 39.13%. 3913 39.13% . 39 13 (39.13%) 83%. 83 83% (83%) histology Microscopically infection wasnt wasn t infections 4 (47 391 39.13 3 1 (39.13% 8 (83% (4 39.1 (39.13 (83 ( 39. (39.1 (8 (39. (39 (3

Abstract In 2015-2016, the Zika virus (ZIKV) caused a major epidemic in the Americas, increasing cases of microcephaly and Guillain-Barré syndrome. During this period, the discovery of ZIKV sexual transmission intensified studies on the impact of this virus on the reproductive organs. For this study, 2-month-old male BALB/c mice were infected with 1.26 x 106 PFU/mL of ZIKV in solution via the intravenous route. After three, seven, and fourteen days post-infection (DPI), blood and testicle samples were obtained to detect ZIKV RNA. The authors observed that the infected animals had slower weight gain than the control group. Viremia occurred only at 3DPI, and the ZIKV RNA was detected in one testis sample at 7DPI. The histopathological analysis of this organ revealed intense disorganization of the seminiferous tubules' structure, inflammatory infiltrate, necrosis, hemorrhage, fluid accumulation, congestion of blood vessels, and reduced sperm count. Ultrastructural analysis showed nuclear changes in tubule cells, activation of interstitial cells, and morphological changes in spermatozoa, in addition to fragmentation and decreased electron density of the genetic material of these cells. Thus, despite causing predominantly asymptomatic infections, ZIKV can cause significant subclinical and transient damage, including to male reproductive organs. 20152016, 20152016 2015 2016, 2016 2015-2016 (ZIKV Americas GuillainBarré Guillain Barré syndrome period organs study 2monthold monthold 2 month old BALBc BALB c 126 1 26 1.2 10 PFUmL PFU mL route three seven postinfection post infection DPI, DPI , (DPI) group 3DPI 7DPI tubules structure infiltrate necrosis hemorrhage accumulation vessels count cells spermatozoa Thus infections damage 2015201 201 2015-201 12 1. (DPI 201520 20 2015-20 20152 2015-2 2015-