Abstract Background The treatment for atopic dermatitis (AD) has been the focus of clinical research, and behavioral intervention is considered an indispensable treatment method. To our knowledge, no relevant meta-analysis has evaluated the effects of behavioral interventions on atopic dermatitis. Objectives To evaluate the effects of behavioral interventions on atopic dermatitis. Methods The authors searched PubMed, EMBASE, and Cochrane CENTRAL to retrieve relevant RCTs (up to Feb 2022). The search strategy involved a combination of related keywords. The Cochrane Q and I2 statistics were used to assess heterogeneity. Results Six RCTs involving seven reports with 246 patients were included. The results suggested that behavioral interventions could relieve eczema severity (correlation coefficient [r = −0.39]; p < 0.001) and scratching severity significantly (r = −0.19; p = 0.017), while not affect itching intensity (r = −0.02; p = 0.840). A sensitivity analysis confirmed the robustness of the results. Study limitations An important limitation of this study was the insufficient number of RCTs and the limited sample size. In addition, the study lacked a control group receiving a type of intervention other than the experimental protocol. Another limitation was the short duration of follow-up. Conclusions This study suggests that behavioral interventions could be effective in treating atopic dermatitis by reducing eczema and scratching severity. Additionally, habit-reversal behavioral therapy may be more effective for treating atopic dermatitis. AD (AD research method knowledge metaanalysis meta PubMed EMBASE up 2022. 2022 . 2022) keywords I heterogeneity 24 included correlation r −0.39 039 0 39 −0.39] 0.001 0001 001 −0.19 019 19 0.017, 0017 0.017 , 017 0.017) −0.02 002 02 0.840. 0840 0.840 840 0.840) size addition protocol followup. followup follow up. follow-up Additionally habitreversal habit reversal 202 2 −0.3 03 3 0.00 000 00 −0.1 01 1 0.01 −0.0 084 0.84 84 20 −0. 0.0 08 0.8 8 −0 0. −

RESUMEN Introducción: En Santa Clara se recibieron los primeros casos diagnosticados en Cuba de la COVID-19. A partir de alteraciones emocionales reportadas se decidió utilizar la psicoterapia cognitivo conductual como recurso terapéutico para tratar los estados depresivos consecuentes. Objetivo: Evaluar la efectividad de la psicoterapia cognitivo conductual bajo estado hipnótico en pacientes con depresión post-COVID-19. Métodos: Se realizó un estudio explicativo con enfoque cuantitativo. La muestra se seleccionó de manera aleatoria en 30 pacientes divididos en 2 grupos, ingresados entre abril y septiembre del 2020 y diagnosticados con la COVID-19. Se empleó el inventario de depresión de Beck para evaluar el estado depresivo antes y después de la intervención con psicoterapia en estado de vigilia y en hipnosis. Resultados: En ambos grupos, los síntomas depresivos desaparecieron, en el 97 % de los pacientes el estado depresivo se eliminó. La psicoterapia de enfoque cognitivo conductual en estado de vigila e hipnótico se consideró efectiva en la depresión post-COVID-19 a partir de evaluar mejoría en más del 50 % de los casos. El grupo que recibió la psicoterapia en estado hipnótico necesitó la mitad de las sesiones que el grupo en vigilia. Conclusiones: La terapia cognitivo conductual en estado hipnótico es efectiva, reduce las distorsiones cognitivas, los niveles de depresión y la sintomatología depresiva.

ABSTRACT Introduction: The first cases diagnosed in Cuba of COVID-19 were received in Santa Clara. Based on reported emotional disturbances, it was decided to use Cognitive Behavioral psychotherapy as a therapeutic resource to treat consequent depressive states. Objective: To evaluate the effectiveness of Cognitive Behavioral psychotherapy under hypnosis in patients with post-COVID-19 depression. Methods: An explanatory study with a quantitative approach was carried out. The sample was randomly selected in 30 patients divided into 2 groups, admitted between April and September 2020 and diagnosed with COVID-19. The Beck Depression Inventory was used to assess depressive state before and after the intervention with psychotherapy in the waking state and in hypnosis. Results: In both groups, the depressive symptoms disappeared, in 97% of the patients the depressive state was eliminated. Psychotherapy with a Cognitive Behavioral approach in a vigilant and hypnotic state was considered effective in post-COVID-19 depression after evaluating improvement in more than 50% of cases. The group that received psychotherapy in a hypnotic state required half as many sessions as the waking group. Conclusions: Cognitive behavioral therapy in a hypnotic state is effective, reducing cognitive distortions, levels of depression and depressive symptoms.

Abstract Objective: This study aims at shedding light on online child psychotherapy using cognitive-behavioral therapy as well as suggesting forms of psychological interventions during a pandemic. Method: Since the beginning of the recent coronavirus (SARS-CoV-2) outbreak, which causes COVID-19, there has been a great concern about a disease that has rapidly spread over the world, bringing about several different socio-economic issues. The fear of contracting the disease has led to safety measures and uncertainties with regard to the future, and it is believed that social isolation has had a direct and psychological impact on both adults and children. This way, we conducted a systematic search for literature review articles. Results: The clinical practice has led to observe that children had their routine interrupted and, consequently, prevented from basic activities such as going to school, being separated from friends, being apart from grandparents, spending the day with their parents, and not to mention, depending on their age, attending online classes in the most varied ways. Conclusion: It is clear that through the use of cognitive-behavioral therapy, forms of psychological interventions can be suggested in the face of the COVID-19 pandemic. Thus, it is clear that effective results are possible with online intervention. Objective cognitivebehavioral cognitive behavioral pandemic Method SARSCoV2 SARSCoV SARS CoV 2 (SARS-CoV-2 outbreak COVID19, COVID19 COVID 19, 19 world socioeconomic socio economic issues future way articles Results consequently school friends grandparents parents mention age ways Conclusion COVID-1 Thus intervention (SARS-CoV- COVID1 1 COVID- (SARS-CoV

Resumo Objetivo: O objetivo deste estudo é sistematizar conhecimentos sobre o atendimento online infantil através da terapia cognitivo-comportamental e sugerir formas de intervenções psicológicas diante da pandemia de COVID-19. Método: Desde o início do surto do coronavírus (SARS-CoV-2), causador da COVID-19, houve preocupação diante de uma doença que se alastrou rapidamente em várias regiões do mundo, com diferentes impactos. Além do medo de contrair a doença, dos cuidados com os familiares e das incertezas frente ao futuro, o isolamento causou impactos psicológicos diretamente relacionados à COVID-19 tanto em adultos como em crianças. Deste modo, foi feita uma busca sistemática por artigos. Resultados: A prática clínica levou ao entendimento de que as crianças passaram por mudanças, como a interrupção das idas à escola, o afastamento dos amigos e dos avós e a presença dos pais o dia todo em casa, além de, dependendo da idade, aulas online em diversos estilos, e a percepção de que os pais também não sabiam como lidar com a situação. Conclusão: Percebe-se que através do uso da terapia cognitivo-comportamental pode-se sugerir formas de intervenções psicológicas diante da pandemia de COVID-19. Assim, nota-se que resultados efetivos são possíveis com a intervenção on-line. Objetivo cognitivocomportamental cognitivo comportamental COVID19. COVID19 COVID 19. 19 Método SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2 , (SARS-CoV-2) COVID19, 19, mundo futuro COVID-1 modo artigos Resultados mudanças escola casa idade estilos situação Conclusão Percebese Percebe podese pode Assim notase nota online. on line. line on-line COVID1 1 (SARS-CoV-2 COVID- (SARS-CoV- (SARS-CoV

RESUMO JUSTIFICATIVA E OBJETIVOS: A dor crônica tem um impacto significativo na qualidade de vida dos pacientes e o uso de terapia farmacológica muitas vezes é insuficiente. As terapias baseadas em Mindfulness (Atenção Plena) apresentam-se de diversas formas e têm sido utilizadas como estratégia no manejo dessa condição. As práticas podem conduzir a atenção ao presente, auxiliar na reinterpretação da dor e aprimorar habilidades de controle físico e emocional via córtex cingulado, somatossensorial, opérculo parietal, cúneo e ínsula anterior. O objetivo deste estudo foi avaliar a Mindfulness quanto a sua influência na qualidade de vida dos pacientes com dor crônica não oncológica e as alterações neurais que essa prática promove, como maior ou menor ativação ou variação de tamanho de áreas como a ínsula e córtex cingulado, e como estas interferem na percepção da dor, tendo como finalidade verificar a aplicabilidade da Atenção Plena como método complementar ao tratamento nesse grupo de pacientes. CONTEÚDO: Revisão Sistemática submetida no banco de dados PROSPERO sob o número 359011. Realizou-se a busca nas bases de dados Pubmed, Medline, LILACS e DIALNET entre 2019 e 2022 com os descritores e operador booleano [(MINDFULNESS) AND (CHRONIC PAIN)]. Incluiu-se na seleção de artigos ensaios clínicos randomizados, estudos de coorte e estudos de caso controle nos idiomas inglês, espanhol e português. O risco de viés foi avaliado pelo ROB2 e a qualidade de evidência por meio do GRADE. Após análise, 10 estudos foram avaliados como essenciais para esta revisão. Foram incluídos os artigos que abordavam intervenção em Mindfulness para dor crônica que responderam e agregaram informações à pergunta da pesquisa e excluídos os artigos que não possuem o foco em “Mindfulness” e “dor crônica”, estudos sem livre acesso e textos cujos resultados não foram publicados até a data da busca. Para analisar as terapias de Mindfulness, os estudos, em sua maioria, abordam mais de 50 pacientes e usam escalas como o Brief Pain Inventory (BPI-DPN Q4), Patient Global Impression of Change (PGIC), Five Facet Mindfulness Questionnaire (FFMQ), Chronic Pain Acceptance Questionnaire (CPAQ) e Pain Catastrophizing Scale (PCS). CONCLUSÃO: A prática de Mindfulness é capaz de diminuir a dor crônica e melhorar sua percepção, aceitabilidade e qualidade de vida ao possibilitar a redução do sofrimento, ansiedade e estresse associados à dor por meio de alterações neurais. Por haver limitações nos estudos com relação à população-alvo específica e à padronização de avaliação, recomenda-se que artigos futuros abordem a prática em crianças, idosos e atletas com dor crônica, além de metodologia detalhada para avaliar e promover as sessões. Ressalta-se que a Mindfulness não é uma cura para a dor crônica, no entanto apresenta segurança e eficácia em seus diferentes protocolos de aplicação, com nível de evidência similar à terapia cognitiva comportamental. OBJETIVOS insuficiente apresentamse apresentam se condição presente cingulado somatossensorial parietal anterior promove CONTEÚDO 359011 Realizouse Realizou Pubmed Medline 201 202 MINDFULNESS [(MINDFULNESS CHRONIC PAIN. PAIN . PAIN)] Incluiuse Incluiu randomizados inglês português ROB GRADE análise 1 revisão “Mindfulness , crônica” maioria 5 BPIDPN BPI DPN Q4, Q4 Q Q4) PGIC, PGIC (PGIC) FFMQ, FFMQ (FFMQ) CPAQ (CPAQ PCS. PCS (PCS) CONCLUSÃO sofrimento populaçãoalvo população alvo avaliação recomendase recomenda crianças sessões Ressaltase Ressalta aplicação comportamental 35901 20 PAIN) (PGIC (FFMQ (PCS 3590 2 359 35 3

ABSTRACT BACKGROUND AND OBJECTIVES: Chronic pain has a significant impact on patients’ quality of life and the use of drug therapy is often insufficient. Therapies based on Mindfulness come in different forms and have been used as a strategy to manage this condition. Practices can guide attention to the present, help reinterpret pain and improve physical and emotional control skills via the cingulate cortex, somatosensory cortex, parietal operculum, cuneus, and anterior insula. This study seeks to evaluate the results of Mindfulness in terms of its influence on the quality of life of patients with chronic non-cancer pain and the neural changes that this practice promotes, such as greater or lesser activation or variation in size of areas as insula and cingulate cortex, and how these interfere with the perception of pain, with the aim of verifying the applicability of Mindfulness as a complementary method to treatment in this group of patients. CONTENTS: Systematic Review submitted to PROSPERO datadase under number 359011. The search was carried out in the Pubmed, Medline, LILACS and DIALNET databases between 2019 and 2022 with the descriptors and Boolean operator [(MINDFULNESS) AND (CHRONIC PAIN)]. The selection of articles includes randomized clinical trials, cohort studies and case control studies in English, Spanish and Portuguese languages. The risk of bias was assessed using ROB2 and the quality of evidence using GRADE. After analysis, ten studies were assessed as essential for this review. Articles that addressed Mindfulness intervention for chronic pain that responded and added information to the research question were included and articles that did not focus on “Mindfulness” and “chronic pain”, studies without free access and texts whose results were not published up to the date of the search were excluded. To analyze Mindfulness therapies, the majority of studies cover more than 50 patients and use scales such as the Brief Pain Inventory (BPI-DPN Q4), Patient Global Impression of Change (PGIC), Five Facet Mindfulness Questionnaire (FFMQ), Chronic Pain Acceptance Questionnaire (CPAQ) and Pain Catastrophizing Scale (PCS). CONCLUSION: The practice of Mindfulness can reduce chronic pain and improving its perception, acceptability and quality of life by enabling the reduction of suffering, anxiety and stress associated with pain through neural changes. As there are limitations in the studies regarding the specific target population and standardization of assessment, it is recommended that future articles address the practice in children, the elderly and athletes with chronic pain, in addition to a detailed methodology to evaluate and promote the sessions. It should be noted that Mindfulness is not a cure for chronic pain, however it presents safety and effectiveness in its different application protocols, with a level of evidence similar to cognitive behavioral therapy. OBJECTIVES insufficient condition present cortex operculum cuneus noncancer non cancer promotes CONTENTS 359011 Pubmed Medline 201 202 MINDFULNESS [(MINDFULNESS CHRONIC PAIN. PAIN . PAIN)] trials English languages ROB GRADE analysis review “Mindfulness , pain” excluded therapies 5 BPIDPN BPI DPN Q4, Q4 Q Q4) PGIC, PGIC (PGIC) FFMQ, FFMQ (FFMQ) CPAQ (CPAQ PCS. PCS (PCS) CONCLUSION suffering assessment children sessions protocols 35901 20 PAIN) (PGIC (FFMQ (PCS 3590 2 359 35 3

Abstract Objective To investigate whether additional Cognitive Behavior Therapy (CBT) combined with conventional therapy improves outcomes for patients with Persistent Postural-Perceptual Dizziness (PPPD) compared with conventional therapy alone. Methods Two reviewers independently searched PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov for relevant Randomized Controlled Trials (RCTs) examining CBT for PPPD which were conducted and published in English from January 2002 to November 2022. RCTs reporting any indicators for assessing corresponding symptoms of PPPD were included, such as Dizziness Handicap Inventory (DHI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Two independent reviewers conducted extraction of relevant information and evaluation of risk of bias. The Cochrane Collaboration risk of bias tool version 1.0 was used to evaluate risks and assess the quality of the included studies, and Cochrane Review Manager 5.3 software (RevMan 5.3) was used to perform meta-analyses. Results The results of six RCTs indicated that combining additional CBT with conventional therapy significantly improved outcomes for PPPD patients compared with conventional therapy alone, especially in DHI-Total scores (Mean Difference [MD = −8.17], 95% Confidence Interval [95% CI: −10.26, −6.09], p< 0.00001), HAMA scores (MD = −2.76, 95% CI: [−3.57, −1.94], p< 0.00001), GAD-7 scores (MD = −2.50, 95% CI [−3.29, −1.70], p< 0.00001), and PHQ-9 scores (MD = −2.29, 95% CI [−3.04, −1.55], p< 0.00001). Subgroup analysis revealed a significant benefit of additional CBT compared with conventional therapies alone, including Vestibular Rehabilitation Therapy (VRT) (MD = −8.70, 95% CI: [−12.17, −5.22], p< 0.00001), Selective Serotonin Reuptake Inhibitor (SSRI) (with controlled SSRI: MD = −10.70, 95% CI: [−14.97, −6.43], p< 0.00001), and VRT combined with SSRI (MD = −6.08, 95% CI [−9.49, −2.67], p= 0.0005) in DHI-Total scores. Conclusion Additional CBT combined with conventional therapy may provide additional improvement for patients with PPPD compared with conventional therapy alone. However, more RCTs are needed to support and guide the application of CBT in treating PPPD. Level of evidence: I; Systematic review of RCTs. (CBT PosturalPerceptual Postural Perceptual (PPPD alone PubMed Embase Science Library ClinicalTrialsgov ClinicalTrials gov (RCTs 200 2022 DHI, DHI , (DHI) HAMA, (HAMA) HAMD, HAMD (HAMD) HADS, HADS (HADS) Questionnaire9 Questionnaire 9 Questionnaire- PHQ9. PHQ9 PHQ . (PHQ-9) 10 1 0 1. studies 53 5 3 5. RevMan metaanalyses. metaanalyses meta analyses. analyses meta-analyses DHITotal Total Mean −8.17, 817 −8.17 8 17 −8.17] 95 [95 1026 26 −10.26 −6.09, 609 −6.09 6 09 −6.09] p 0.00001, 000001 0.00001 00001 0.00001) 276 2 76 −2.76 −3.57, 357 57 [−3.57 −1.94, 194 −1.94 94 −1.94] GAD7 GAD 7 GAD- 250 50 −2.50 −3.29, 329 29 [−3.29 −1.70, 170 −1.70 70 −1.70] PHQ- 229 −2.29 −3.04, 304 04 [−3.04 −1.55, 155 −1.55 55 −1.55] 0.00001. (VRT 870 −8.70 −12.17, 1217 12 [−12.17 −5.22, 522 −5.22 22 −5.22] (SSRI 1070 −10.70 −14.97, 1497 14 97 [−14.97 −6.43, 643 −6.43 43 −6.43] 608 08 −6.08 −9.49, 949 49 [−9.49 −2.67, 267 −2.67 67 −2.67] 0.0005 00005 0005 However evidence I 20 202 (DHI (HAMA (HAMD (HADS (PHQ-9 81 −8.1 [9 102 −10.2 60 −6.0 00000 0.0000 0000 27 −2.7 −3.57 35 [−3.5 19 −1.9 25 −2.5 −3.29 32 [−3.2 −1.7 −2.2 −3.04 30 [−3.0 15 −1.5 87 −8.7 −12.17 121 [−12.1 52 −5.2 107 −10.7 −14.97 149 [−14.9 64 −6.4 4 −9.49 [−9.4 −2.6 0.000 000 (PHQ- −8. [ −10. −6. −2. −3.5 [−3. −1. −3.2 −3.0 −12.1 [−12. −5. −14.9 [−14. −9.4 [−9. 0.00 00 (PHQ −8 −10 −6 −2 −3. [−3 −1 −12. [−12 −5 −14. [−14 −9. [−9 0.0 − −3 [− −12 [−1 −14 −9 0.

Abstract Objective: To investigate the relative effectiveness of various Non-Invasive Treatment Techniques (NITs) in chronic tinnitus management. Methods: We searched PubMed, Embase and Cochrane Library databases from the time of data construction to December 31, 2022. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, NITs were evaluated, including Aacceptance and commitment therapy (A), Cognitive behavioral therapy (C), Sound therapy (S), Transcranial magnetic stimulation (T), Electrical stimulation therapy (E), Virtual reality therapy (V), tinnitus Retraining therapy (R), general psychotherapy (D), and Placebo (P). The outcome indicators included the Tinnitus Handicap Inventory (THI), Tinnitus Questionnaire (TQ), Hospital Anxiety and Depression Scale-anxiety-Depression (HADS-D), Insomnia Severity Index (ISI), Visual Analogue Scales-Loudness (VAS-L), and Visual Analogue Scales-Distress (VAS-D). Statistical analysis was performed using Stata 14.0 for NMA. Results: This systematic review and meta-analysis included 22 randomized controlled trials comprising 2,354 patients. The treatment effects varied on each scale. For THI, S (86.9%) was the most effective, whereas P (6.5%) was the worst. For TQ, C (89.5%) was the most effective, whereas D (25.4%) was the worst. For HADS-D, A (82.4%) was the most effective, whereas D (9.47%) was the worst. For ISI, A (83.2%) was the most effective, whereas R (20.6%) was the worst. For VAS-L, S (73.5%) was the most effective, whereas E (18.9%) was the worst. For VAS-D, C (84.7%) was the most effective, whereas P (18.1%) was the worst. Conclusions: The combination of acoustics and cognitive behavioral therapy may be an effectively treat patients with chronic tinnitus. Level of evidence: How common is the problem? Level 2. Is this diagnostic or monitoring test accurate? (Diagnosis) Level 1. What will happen if we do not add a therapy? (Prognosis) Level 1. Does this intervention help? (Treatment Benefits) Level 1. What are the COMMON harms? (Treatment Harms) Level 1. What are the RARE harms? (Treatment Harms) Level 1. Is this (early detection) test worthwhile? (Screening) Level 1I. Objective NonInvasive Non Invasive (NITs management Methods PubMed 31 2022 MetaAnalyses Meta Analyses guidelines evaluated A, , (A) C, (C) S, (S) T, T (T) E, (E) V, V (V) R, (R) D, (D) P. . (P) THI (THI) TQ (TQ) ScaleanxietyDepression Scale anxiety HADSD, HADSD HADS (HADS-D) ISI (ISI) ScalesLoudness Scales Loudness VASL, VASL VAS L (VAS-L) ScalesDistress Distress VASD. VASD (VAS-D) 140 14 0 14. NMA Results metaanalysis meta 2 2354 354 2,35 scale 86.9% 869 86 9 (86.9% effective 6.5% 65 6 5 (6.5% worst 89.5% 895 89 (89.5% 25.4% 254 25 4 (25.4% HADS-D 82.4% 824 82 (82.4% 9.47% 947 47 (9.47% 83.2% 832 83 (83.2% 20.6% 206 20 (20.6% L, VAS-L 73.5% 735 73 (73.5% 18.9% 189 18 (18.9% VASD, VAS-D 84.7% 847 84 7 (84.7% 18.1% 181 1 (18.1% Conclusions evidence problem accurate Diagnosis (Diagnosis Prognosis (Prognosis help Benefits harms Harms early detection worthwhile Screening (Screening 1I I 3 202 (A (C (S (T (E (V (R (D (P (THI (TQ (HADS-D (ISI (VAS-L (VAS-D 235 35 2,3 86.9 8 (86.9 6.5 (6.5 89.5 (89.5 25.4 (25.4 82.4 (82.4 9.47 94 (9.47 83.2 (83.2 20.6 (20.6 73.5 (73.5 18.9 (18.9 84.7 (84.7 18.1 (18.1 23 2, 86. (86. 6. (6. 89. (89. 25. (25. 82. (82. 9.4 (9.4 83. (83. 20. (20. 73. (73. 18. (18. 84. (84. (86 (6 (89 (25 (82 9. (9. (83 (20 (73 (18 (84 (8 ( (2 (9 (7 (1

Resumen El presente estudio propone analizar la eficacia de la terapia que integra el enfoque cognitivo conductual y el centrado en soluciones para reducir el estrés infantil ocasionado por el COVID-19. La modalidad empleada fue mediante un taller en línea, el cual consistió en 5 sesiones semanales, en dónde se aplicaron las estrategias de reestructuración cognitiva, psicoeducación, solución de problemas, adiestramiento en autoinstrucciones, mindfulness, pregunta escala y excepciones. Se contó con la asistencia de siete personas (cinco niñas y dos niños) de entre 9 y 12 años, quienes mediante la evaluación del inventario de estrés cotidiano infantil demostraron una disminución en el estrés percibido; y, en el Child and Adolescent Mindfulness Measure, un aumento en habilidades de relajación y atención plena. La prueba no paramétrica de rangos Wilcoxon indicó cambios significativos y con el tamaño de efecto encontrado se puede concluir que el taller en línea, diseñado con técnicas cognitivo conductuales y centrada en soluciones, es una buena opción para tratar temas de estrés en la población infantil.

Abstract The present study proposes to analyze the efficacy of the integration of the cognitive behavioral and the solutions focused on therapies to reduce childhood stress caused by COVID-19. The modality featured used was through an online workshop, which consisted of five5 weekly sessions and in which the strategies of Cognitive Restructuring, Psychoeducation, Problem-Solving, Training in Self-Instructions, Mindfulness, Scale Question, and Exceptions were applied. Seven people (five women and two men) between 9 and 12 years old attended the workshop. The evaluation of the Child Daily Stress Inventory demonstrated a decrease in perceived stress among the participants and the Child and Adolescent Mindfulness Measure an increase in relaxation and mindfulness skills. The non-parametric Wilcoxon rank test supports the hypothesis that there were significant differences after the intervention. Thus, it can be concluded that the online workshop, designed with cognitive behavioral and focused on solutions therapies, is a good option to deal with stress-related issues in the child population.

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD. Objectives evidencebased based cognitivebehavioral cognitive behavioral (CBT obsessivecompulsive obsessive compulsive OCD . (OCD) Methods clinicians protocol 20132020 2020 2013-202 PubMed, PubMed (PubMed Cochrane Embase PsycINFO Lilacs design measures type language tools Results 4 201 Highquality High firstline first line Internetdelivered Internet delivered Conclusion (OCD 2013202 202 2013-20 20 201320 2013-2 2 20132 2013-

Abstract Introduction: In 2018, an observational study developed at a Portuguese Primary Care Health Unit estimated a mild cognitive impairment (MCI) prevalence of 29.1%, with an association between better performance in Montreal Cognitive Assessement (MoCA) test and reading of newspapers and books or hobbies. The objective of the present project was to improve the cognitive capacity of the elderly with MCI through cognitive training activities. Methods: We conducted an intervention project in a Primary Care Health Unit, with a sample of 20 elderly with MCI. Cognitive training sessions took place with delivery of homework exercise books. The Portuguese version of MoCA was applied at zero, three and six months to evaluate cognitive performance. Results: At the beginning of the study, the median MoCA score was 18.5. After six months, a median score of 23 was observed. There was an improvement in the global score at all cognitive domains except language and orientation. Conclusion: The cognitive performance improved after the six months period achieving our purpose. Cognitive training has a potential beneficial effect on the health of the elderly population and requires simple, low-cost materials that can be applied in nursing homes and day care centers through caregivers.

Resumo Introdução: Em 2018, um estudo de investigação realizado numa Unidade de Saúde Familiar (USF) estimou uma prevalência de défice cognitivo ligeiro (DCL) de 29,1%, verificando-se uma associação entre o melhor desempenho no teste Montreal Cognitive Assessement (MoCA) com a leitura de jornais e livros e a realização de passatempos. O objetivo do projeto foi melhorar a capacidade cognitiva nos idosos com DCL através de atividades de treino cognitivo. Métodos: Projeto de intervenção realizado numa USF com uma amostra de 20 idosos com DCL. Decorreram sessões presenciais de treino cognitivo e foram entregues cadernos de trabalhos de casa. Foi aplicado o MoCA versão portuguesa aos zero, três e seis meses para avaliação do desempenho cognitivo. Resultados: No início do estudo, a pontuação mediana no MoCA foi 18,5. Após seis meses, registou-se uma pontuação mediana de 23. Verificou-se uma melhoria da pontuação global em todos os domínios cognitivos, com exceção da linguagem e da orientação. Conclusão: O objetivo foi atingido pela melhoria do desempenho cognitivo após seis meses de estudo. O treino cognitivo tem um potencial efeito benéfico na saúde da população idosa e requer materiais de simples elaboração e baixo custo que podem ser aplicados em lares de idosos e centros de dia através dos cuidadores.

Abstract: The present investigation consisted of a single case study of a 10-year-old child from international adoption with symptoms of Fetal Alcohol Spectrum Disorder (FASD). Due to the symptomatological complexity of the disorder and its diagnosis, currently there are no effective treatments. The study started with a neurocognitive evaluation where alterations in attention, memory and executive functions were observed, which manifested themselves in great impulsivity, as well as in difficulties in self-regulation. A 96-ses- sion neurorehabilitation program was designed, focusing on a multidisciplinary approach to the altered cognitive, behavioral and functional aspects. The application of the rehabilitation program produced a general improvement in the patient's functional capacity, specially in attention processes and the capacity for self-regulation. The results obtained highlight the value of the application of multidisciplinary neurorehabilitation programs as an effective tool in the treatment of the clinical symptoms of FASD and the improvement in the adaptation of patients to the demands of their daily lives.

Resumen: La presente investigación consistió en un estudio de caso único de un niño de 10 años, procedente de adopción internacional, con síntomas compatibles con trastorno del espectro alcohólico fetal (TEAF). Debido a la complejidad sintomatológica del trastorno y de su diagnóstico, en la actualidad no existen tratamientos contrastados. El estudio comenzó con una evaluación neurocognitiva donde se observaron alteraciones en atención, memoria y funciones ejecutivas, que se manifestaron en una gran impulsividad, así como en dificultades para la autorregulación. Se diseñó un programa de neurorreha- bilitación, de 96 sesiones, centrado en el abordaje multidisciplinar de los aspectos cognitivos, conductuales y funcionales alterados. La aplicación del programa de rehabilitación produjo mejora general en la capacidad funcional del paciente, destacando los procesos de atención y en la capacidad de autorregulación. Los resultados obtenidos ponen en valor la aplicación de programas de neurorrehabilitación multidisciplinares al revelarse como una herramienta eficaz en el tratamiento de la sintomatología clínica del TEAF y la mejora en la adaptación de los pacientes a las exigencias de su vida diaria.

Resumen Antecedentes Se estima que el duelo secundario a COVID-19 dejará cerca de 16 millones de personas afectadas mundialmente, y la prevalencia del Trastorno de Duelo Prolongado (TDP) pudiera incrementarse al 40%. Objetivo Revisar los tratamientos susceptibles de aplicar en pacientes con TDP por COVID-19. Método Se realizó la búsqueda en PUBMED y Scholar google con las palabras clave trastorno de duelo prolongado, duelo complicado, duelo y psicoterapia y tratamiento del duelo prolongado o complicado o complejo persistente. Resultados Se revisaron 50 artículos, se refirió la eficacia de la terapia interpersonal, la terapia racional emotiva del comportamiento, la terapia de apoyo, la terapia humanista, la terapia familiar sistémica, la terapia grupal, la terapia de escritura, la intervención basada en internet, y una modalidad de terapia cognitivo conductual aplicada al duelo prolongado, la terapia metacognitiva y la terapia de aceptación y compromiso. Discusión y conclusión No hay consenso sobre el uso preferencial de tratamientos psicoterapéuticos en personas con TDP por la pérdida de una familiar por COVID-19. La terapia grupal es efectiva en disminuir la intensidad del duelo no complicado, la terapia cognitivo conductual es altamente efectiva para disminuir la gravedad del duelo, la Terapia Metacognitiva diseñada específicamente para el TDP impacta positivamente en la depresión, ansiedad y calidad de vida; y la Terapia de Aceptación y Compromiso es útil en el restablecimiento de la espiritualidad. La psicoterapia es más eficaz cuando se combina con terapia farmacológica. Se sugiere la realización de estudios comparativos entre técnicas psicoterapéuticas para el manejo de pacientes con TDP asociado a COVID-19 y la adaptación de estas técnicas a ambientes virtuales.

Abstract Background It has been estimated that COVID-19 grief will affect approximately sixteen million people worldwide, while the prevalence of prolonged grief disorder (PGD) could rise to 40%. Objective To review treatments that can be administered to patients with PGD due to COVID-19. Method PUBMED and Google Scholar were searched with the following keywords: prolonged grief disorder, complicated grief, grief and psychotherapy, and treatment of prolonged grief, complicated grief or persistent complex grief. Results Fifty articles were reviewed on the efficacy of interpersonal therapy, rational emotional-behavioral therapy, supportive therapy, humanistic therapy, systemic family therapy, group therapy, writing therapy, Internet-based intervention, and a modality of cognitive behavioral therapy used with prolonged grief, metacognitive therapy, and acceptance and commitment therapy. Discussion and conclusion There is no consensus on the psychotherapeutic treatment of choice for people with PGD due to the loss of a family member to COVID-19. Group therapy is effective in reducing the intensity of uncomplicated grief, cognitive-behavioral therapy is highly efficacious in reducing the severity of grief, metacognitive therapy specifically designed for PGD has a positive impact on depression, anxiety, stress, rumination, and quality of life while Acceptance and Commitment Therapy is helpful for restoring spirituality. Psychotherapy is most effective when combined with drug therapy. It is suggested that comparative studies be undertaken of psychotherapeutic techniques for managing patients with PGD associated with COVID-19 and the adaptation of these techniques to virtual settings.

Resumen El Trastorno de evitación/restricción de la ingesta de alimentos (TERIA) tiene una presentación clínica compleja. Desde su reconocimiento en el DSM-5 se han realizado investigaciones que aportan datos de esta condición, sin embargo, su tratamiento se ha reportado mayormente en estudios de casos. Por tanto, el objetivo del presente estudio fue analizar las características e intervenciones clínicas de estudios y series de casos del TERIA, a partir de una revisión de la literatura con base a los lineamientos PRISMA y CARE. En total se examinaron 41 artículos, la mayoría de los casos reportados fueron en hombres (53.85%) con edades entre 10 a 13 (29.23%), aunque, 15.38% de los casos tenían un rango de edad de 20 a 56 años. En cuanto a sus síntomas, el más frecuente fue el bajo peso (66.15%), sin embargo, 3.08% de estos pacientes presentaba sobrepeso ligado al consumo de carbohidratos. Las comorbilidades psiquiátricas más frecuentes fueron los trastornos de ansiedad (38.46%). Por último, el tratamiento más utilizado fue el hospitalario (46.34%), con abordaje multidisciplinar (65.85%) y en cuanto a la intervención psicológica más utilizada fue la Terapia Cognitivo Conductual (21.95%).

Abstract Avoidant/restrictive food intake disorder (ARFID) has a complex clinical presentation. Since its recognition in the DSM-5, investigations have provided data of this condition, however, its treatment has mostly been reported in case studies. Therefore, the objective of the present study was analyzed clinical characteristics and clinical interventions reported in case reports and case series studies of ARFID, from a literature review according to the PRISMA and CARE guidelines. In total, 41 articles were examined, most of the reported cases were males (53.85%) with ages between 10 to 13 (29.23%), although, 15.38% of the cases had an age range of 20 to 56. Regarding their symptoms, the most frequent was underweight (66.15%), however, 3.08% of these patients were overweight linked to carbohydrate consumption. The most frequent psychiatric comorbidities were anxiety disorders (38.46%). Lastly, the most widely used was hospital treatment (46.34%), with a multidisciplinary approach (65.85%) and as for the most used psychological intervention was Cognitive Behavioral Therapy (21.95%).

Abstract. Objective. The aim of this study was to analyze the feedback of individuals with obesity diagnosis after 8 Group Cognitive-Behavioral Therapy (GCBT) sessions. Method. 13 patients with previous obesity diagnosis participated. The instrument was an interview conducted at the last meeting of the GCBT; subsequently, a Bardin’s content analysis was carried out. Results. The obtained data was organized into four categories: benefits of participation in the intervention; weight loss and self-esteem; improvement in nutrition quality; and improvement in physical health and life quality. Beyond weight loss, there was an improvement in the quality of nutrition, weight loss, well-being, self-esteem, and, consequently, in the quality of life. Aside from its application in obesity treatment, GCBT can be a promising approach in the treatment of other disorders.

Resumo. Objetivo. Analisar os feedback de indivíduos com diagnóstico de obesidade que realizaram 8 sessões de Terapia Cognitivo Comportamental em Grupo (TCCG). Método. Participaram 13 pacientes com diagnóstico prévio de obesidade. O instrumento foi uma entrevista conduzida no último encontro da TCCG e, posteriormente, foi realizada a análise de conteúdo de Bardin. Resultados. Foram organizadas quatro categorias: benefícios da participação da intervenção, emagrecimento e autoestima, melhora na qualidade da alimentação, melhora na saúde física e qualidade de vida. Além do emagrecimento, houve uma melhora na qualidade da alimentação, perda de peso, bem-estar e autoestima e, consequentemente, na qualidade de vida. Além de sua aplicação no tratamento da obesidade, a TCCG pode ser uma abordagem promissora no tratamento de outros transtornos.

Currently, genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), are predominantly used to model genetic diseases. This genome editing system can correct point or frameshift mutations in risk genes. Here, we analyze and discuss the advantages of genome editing, its current applications, and the feasibility of the CRISPR/Cas9 system in research on psychiatric disorders. These disorders produce cognitive and behavioral alterations and their etiology is associated with polygenetic and environmental factors. CRISPR/Cas9 may reveal the biological mechanisms of psychiatric disorders at a basic research level, translating a suitable clinical approach for use in the diagnosis and treatment of psychiatric disorders. Genetic diagnosis and treatment for these disorders have not yet been fully established in psychiatry due to the limited understanding of their heterogeneity and polygenicity. We discuss the challenges and ethical issues in using CRISPR/Cas9 as a tool for diagnosis or gene therapy. Currently technologies CRISPR/Cas9, CRISPRCas9 CRISPRCas , CRISPR Cas9 Cas (CRISPR/Cas9) diseases genes Here applications CRISPR/Cas factors level polygenicity therapy (CRISPR/Cas9 (CRISPR/Cas

Abstract Background: Violence against women (VAW) and the COVID-19 pandemic are issues that have affected women's mental health, with sequela such as depression. Objective: To compare the efficacy of brief behavioral activation therapy (BATD) and cognitive behavioral therapy (CBT) with cultural adaptations administered online by telehealth for depression in victims of VAW during COVID-19 in Mexico. Method: A randomized clinical trial was conducted with 20 Mexican women aged 18–60 years with depression who experienced VAW in the last six months during COVID-19. Participants were randomized 1:1 to the BATD and CBT groups. For data analysis, Friedman and Mann-Whitney U tests were applied, and the Reliable Change Index was estimated. Results: A decrease in depressive symptoms (p < .001) and an increase in activation levels (p < .001) were found in favor of the BATD group at the end of the intervention and at follow-up, in contrast to CBT. Conclusions: BATD was shown to be effective in health emergency crises in VAW contexts. Gathering evidence of efficient interventions for this population contributes to mitigating mental health conditions.

Resumen Antecedentes: La violencia contra la mujer (VCM) y la pandemia por COVID-19 son problemáticas que han afectado la salud mental de las mujeres, con secuelas como la depresión. Objetivo: Comparar la eficacia del tratamiento breve de activación conductual (BATD) y la terapia cognitiva conductual (TCC) con adaptaciones culturales administradas online (telesalud) para la depresión en víctimas de VCM durante la COVID-19 en México. Método: Se realizó un ensayo clínico aleatorizado con 20 mujeres mexicanas de 18-60 años con depresión que experimentaron VCM en los últimos seis meses durante la COVID-19. Las participantes fueron asignadas de manera aleatorizada 1:1 a los grupos BATD y TCC. Para el análisis de datos se aplicaron las pruebas Friedman y U de Mann-Whitney, y se estimó el Índice de Cambio Confiable. Resultados: Se encontró una disminución en síntomas depresivos (p < .001) e incremento en los niveles de activación (p < .001) a favor del grupo BATD, al término de la intervención y en el seguimiento en contraste con la TCC. Conclusiones: La BATD mostró ser eficaz en crisis de emergencia sanitaria en contextos de VCM. Aunar evidencia de intervenciones eficientes para esta población contribuye a mitigar las afecciones de salud mental.