Abstract: The purpose of this article is to achieve optimal coordination for timed overcurrent relays modeled in a test system. The traditional adjustment that is usually used in the field is taken as the base criterion to determine the improvements achieved with the implemented optimization methods. Optimal parameters are determined for two timed overcurrent relays modeled on the IEEE 13-node test system using PowerFactory software. The optimization algorithms are coded in Python. PowerFactory links with Python to generate interoperability between the algorithm and the electrical system. Satisfactory results are achieved from the COA and GSA algorithms with a reduction of more than 50% in relay operating times.

Resumen: El objeto de este artículo es conseguir la coordinación óptima para los relés de sobrecorriente temporizados, modelados en un sistema de prueba. El ajuste tradicional que se emplea usualmente en el campo se toma como criterio base para determinar las mejoras conseguidas con los métodos de optimización implementados. Se determinan parámetros óptimos para dos relés de sobrecorriente temporizados modelados en el sistema de prueba de 13 nodos de la IEEE mediante el software PowerFactory. Los algoritmos de optimización son codificados en Python. Gracias a la interfaz que presenta PowerFactoy con Python, cada algoritmo se ejecuta dentro del sistema eléctrico. Se consiguen resultados satisfactorios de los algoritmos COA y GSA con una reducción de más del 50 % en los tiempos de operación de los relés.

ABSTRACT Objective: To evaluate the occurrence of aortic dilatation and its associated predictors with coarctation of the aorta (CoA) in infants using multi-slice computed tomography (MSCT). Methods: The clinical data of 47 infantile patients with CoA diagnosed by MSCT and 28 infantile patients with simple ventricular septal defect were analyzed retrospectively. Aortic diameters were measured at six different levels, and aortic sizes were compared by z score. The coarctation site-diaphragm ratio was used to describe the degree of narrowing. Relevant clinical data were collated and analyzed. Results: The dilation rate and z score of the ascending aorta in the severe CoA group were significantly higher than those in the mild CoA group (11 [52.38%] vs. 21 [80.77%], P=0.038 and 2.00 ± 0.48 vs. 2.36 ± 0.43, P=0.010). Pearson’s correlation analysis found that the z score of the ascending aorta was negatively correlated with the coarctation site-diaphragm ratio value (r=-0.410, P=0.004). A logistic retrospective analysis found that an increased degree of coarctation was an independent predictor of aortic dilatation (adjusted odds ratio 0.002; 95% confidence interval 0.00-0.819; P=0.043). The z score of the ascending aorta in the severe CoA group was significantly higher than that in the ventricular septal defect group (P<0.05). Conclusion: Most infants with CoA can also have significant dilatation of the ascending aorta, and the degree of this dilatation is related to the degree of coarctation. Assessment of aortic diameter and related malformations by MSCT can predict the risk of aortic dilatation in infants with CoA. Objective (CoA multislice multi slice MSCT. . (MSCT) Methods 4 2 retrospectively levels sitediaphragm site diaphragm narrowing Results 11 (1 52.38% 5238 52 38 [52.38% vs 80.77%, 8077 80.77% , 80 77 [80.77%] P0038 P 0 038 P=0.03 200 00 2.0 048 48 0.4 236 36 2.3 043 43 0.43 P=0.010. P0010 P=0.010 010 P=0.010) Pearsons Pearson s r=0.410, r0410 r r= 0.410, 410 (r=-0.410 P=0.004. P0004 P=0.004 004 P=0.004) adjusted 0.002 0002 002 95 0.000.819 0000819 0.00 0.819 819 0.00-0.819 P=0.043. P0043 P=0.043 P=0.043) P<0.05. P005 P<0.05 05 (P<0.05) Conclusion (MSCT 1 ( 52.38 523 5 3 [52.38 807 80.77 8 7 [80.77% P003 03 P=0.0 20 2. 04 0. 23 P001 P=0.01 01 r=0.410 r041 0410 0.410 41 (r=-0.41 P000 P=0.00 000 9 0.000.81 000081 0.0 0819 0.81 81 0.00-0.81 P004 P=0.04 P00 P<0.0 (P<0.05 52.3 [52.3 80.7 [80.77 P=0. r=0.41 r04 041 0.41 (r=-0.4 0.000.8 00008 081 0.8 0.00-0.8 P0 P<0. (P<0.0 52. [52. 80. [80.7 P=0 r=0.4 r0 (r=-0. 0.000. 0000 08 0.00-0. P<0 (P<0. [52 [80. P= r=0. (r=-0 0.000 0.00-0 P< (P<0 [5 [80 r=0 (r=- 0.00- (P< [ [8 (r= (P (r

Abstract Medium chain acyl-coA dehydrogenase deficiency (MCADD), the most common fatty acid oxidation disorder, has been regarded as a relatively benign condition with low risk of mortality in patients with a known diagnosis, if adequate caloric intake is met. However, inadequate energy provision, as occurs in eating disorders, significantly amplifies the risk of metabolic decompensation. This case series describes four patients with MCADD and a concomitant eating disorder and aims to raise awareness of the potentially under-recognised coexistence of these conditions. All patients were female with signs of disordered eating in adolescence and young adulthood though latency in diagnosis was apparent. Three of the patients had low body mass index (BMI) and the other was overweight. Metabolic decompensation and hospitalisation occurred in three of four patients secondary to extreme risk-taking behaviour with caloric restriction. The coexistence of MCADD and eating disorders is of significant concern, placing the patient at substantial risk of decompensation in an otherwise relatively stable metabolic condition. Awareness of disordered eating in this population is paramount, as early recognition of signs and symptoms of eating disorders in the MCADD population may facilitate prompt intervention and avoidance of morbidity and potential mortality. acylcoA acyl coA MCADD, , (MCADD) met However provision underrecognised under recognised conditions apparent BMI (BMI overweight risktaking taking restriction concern paramount (MCADD

ABSTRACT Objective: To investigate the effect of improving the operative field and postoperative atelectasis of single-lung ventilation (SLV) in the surgical repair of coarctation of the aorta (CoA) in infants without the use of cardiopulmonary bypass (CPB). Methods: This was a retrospective cohort study. The clinical data of 28 infants (aged 1 to 4 months, weighing between 4.2 and 6 kg) who underwent surgical repair of CoA without CPB from January 2019 to May 2022 were analyzed. Fourteen infants received SLV with a bronchial blocker (Group S), and the other 14 infants received routine endotracheal intubation and bilateral lung ventilation (Group R). Results: In comparison to Group R, Group S exhibited improved exposure of the operative field, a lower postoperative atelectasis score (P<0.001), reduced prevalence of hypoxemia (P=0.01), and shorter durations of operation, mechanical ventilation, and ICU stay (P=0.01, P<0.001, P=0.03). There was no difference in preoperative information or perioperative respiratory and circulatory indicators before SLV, 10 minutes after SLV, and 10 minutes after the end of SLV between the two groups (P>0.05). Intraoperative bleeding, intraoperative positive end-expiratory pressure (PEEP), and systolic pressure gradient across the coarctation after operation were also not different between the two groups (P>0.05). Conclusion: This study demonstrates that employing SLV with a bronchial blocker is consistent with enhanced operative field, reduced operation duration, lower prevalence of intraoperative hypoxemia, and fewer postoperative complications during the surgical repair of CoA in infants without the use of CPB. Objective singlelung single (SLV (CoA . (CPB) Methods 2 aged months 42 4. kg 201 202 analyzed S, , S) R. R R) Results P0001 P P<0.001 0 001 (P<0.001) P=0.01, P001 P=0.01 01 (P=0.01) (P=0.01 P=0.03. P003 P=0.03 03 P=0.03) P>0.05. P005 P>0.05 05 (P>0.05) bleeding endexpiratory expiratory PEEP, PEEP (PEEP) Conclusion duration (CPB 20 P000 P<0.00 00 (P<0.001 P00 P=0.0 (P=0.0 P>0.0 (P>0.05 (PEEP P<0.0 (P<0.00 P0 P=0. (P=0. P>0. (P>0.0 P<0. (P<0.0 P=0 (P=0 P>0 (P>0. P<0 (P<0. P= (P= P> (P>0 P< (P<0 (P (P> (P<

Abstract Hypertensive individuals present alterations in their calcium metabolism that consequently decrease the concentration of this mineral in the bone tissue. Objectives to evaluate the morphological and functional characteristics of the peri-implant bone tissue that was formed during the healing process by the placement implants using two different surface treatments: hydrophilic Acqua™ (ACQ) and rough NeoPoros™ (NEO), in spontaneously hypertensive (SHR) and normotensive rats (Wistar) whether or not treated with losartan. Methodology In total, 96 male rats (48 Wistar and 48 SHR) were divided into eight subgroups: absolute control rough (COA NEO), absolute control hydrophilic (COA ACQ), losartan control rough (COL NEO), losartan control hydrophilic (COL ACQ), SHR absolute rough (SHR NEO), SHR absolute hydrophilic (SHR ACQ), SHR losartan rough (SHRL NEO), and SHR losartan hydrophilic (SHRL ACQ). The rats medicated with losartan received daily doses of the medication. NeoPoros™ and Acqua™ implants were installed in the tibiae of the rats. After 14 and 42 days of the surgery, the fluorochromes calcein and alizarin were injected in the rats. The animals were euthanized 67 days after treatment. The collected samples were analyzed by immunohistochemistry, biomechanics, microcomputerized tomography, and laser confocal scanning microscopy analysis. Results The osteocalcin (OC) and vascular endothelium growth factor (VEGF) proteins had moderate expression in the SHRL ACQ subgroup. The same subgroup also had the highest implant removal torque. Regarding microarchitectural characteristics, a greater number of trabeculae was noted in the control animals that were treated with losartan. In the bone mineralization activity, it was observed that the Acqua™ surface triggered higher values of MAR (mineral apposition rate) in the COA, COL, and SHRL groups (p<0.05). Conclusion the two implant surface types showed similar responses regarding the characteristics of the peri-implant bone tissue, even though the ACQ surface seems to improve the early stages of osseointegration. periimplant peri treatments Acqua (ACQ NeoPoros NEO, NEO , (NEO) (Wistar total 9 (4 4 subgroups COA NEO) ACQ, ACQ) COL ACQ. . medication 1 surgery 6 treatment immunohistochemistry biomechanics tomography analysis OC (OC VEGF (VEGF torque activity rate p<0.05. p005 p p<0.05 0 05 (p<0.05) osseointegration (NEO ( p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

ABSTRACT Introduction: Coarctation of the aorta (CoA) is a narrowing of the thoracic aorta that often manifests as discrete stenosis but may be tortuous or in long segment. The study aimed to evaluate pre and post-surgical aspects of pediatric patients submitted to CoA surgical correction and to identify possible predisposing factors for aortic recoarctation. Methods: Twenty-five patients were divided into groups according to presence (N=8) or absence (N=17) of recoarctation after surgical correction of CoA and evaluated according to clinical-demographic profile, vascular characteristics via computed angiotomography (CAT), and other pathological conditions. Results: Majority of males (64%), ≥ 15 days old (76%), ≥ 2.5 kg (80%). There was similarity between groups with and without recoarctation regarding sex (male: 87% vs. 53%; P=0.277), age (≥ 15 days: 62.5 vs. 82%; P=0.505), and weight (≥ 2.5 kg: 87.5 vs. 76.5; P=0,492). Altered values of aortic root/Valsalva diameter, proximal transverse arch, and distal isthmus, and normal values for aorta prevailed in preoperative CAT. Normal values for the aortic root/Valsalva sinus diameter were observed with and without recoarctation, the same for both groups regarding ascending and descending aorta in postoperative CAT. No significant difference for altered values of proximal transverse arch and alteration in distal isthmus was observed. Conclusion: No predictive risk for recoarctation was observed. CTA proved to be important in CoA diagnosis and management, since CoA is mainly related with altered diameter of aortic root/sinus of Valsalva and proximal and distal aortic arch/isthmus, however, it failed to show predictive risk for recoarctation. Introduction (CoA segment postsurgical post Methods Twentyfive Twenty five N=8 N8 N 8 (N=8 N=17 N17 17 (N=17 clinicaldemographic clinical demographic profile CAT, CAT , (CAT) conditions Results 64%, 64 64% (64%) 1 76%, 76 76% (76%) 25 2 5 2. 80%. 80 80% . (80%) male (male 87 vs 53% 53 P=0.277, P0277 P P=0.277 0 277 P=0.277) ( 625 62 62. 82% 82 P=0.505, P0505 P=0.505 505 P=0.505) 875 87. 76.5 765 P=0,492. P0492 P=0,492 492 P=0,492) rootValsalva root Conclusion management rootsinus archisthmus arch/isthmus however N= (N= N=1 N1 (N=1 (CAT 6 (64% 7 (76% (80% P027 P=0.27 27 P050 P=0.50 50 76. P049 P=0,49 49 (N (64 (76 (80 P02 P=0.2 P05 P=0.5 P04 P=0,4 4 (6 (7 (8 P0 P=0. P=0, P=0 P=

Abstract: Assai (Euterpe oleracea Mart.) cultivars BRS-Pará (BRS-PA) and BRS-Pai d’Égua (BRS-PDE) were selected for cultivation in upland regions of the Amazon. Given these cultivars were developed from different progenitors, we postulated that they differ regarding water-deficit tolerance. To test this hypothesis, plants of both cultivars were evaluated under well-watered (control) and water-deficit conditions (pre-dawn leaf water potential of – 2.33 MPa). Relative to control, the water-deficit decreased net CO2 assimilation rate (A) and transpiration by 82% and 86% in both cultivars, while the stomatal conductance (gs) was reduced by 93% and 87% in stressed plants of BRS-PDE and BRS-PA. The water-deficit improved instantaneous water-use efficiency by 43% in both cultivars, while intrinsic water-use efficiency (A/gs) increased by 193% and 33% in BRS-PDE and BRS-PA. The water-deficit induced 44% increase in foliar proline and 27% decrease in soluble carbohydrates in both cultivars, while foliar sucrose decreased by 53% in BRS-PA and 16% in BRS-PDE in relation to control. The relative water content in stressed plants of both cultivars was decreased by 8.5% in relation to control. In conclusion, the more efficient stomatal opening control and higher A/gs in BRS-PDE indicate this cultivar better copes with drought than BRS-PA. Abstract Euterpe Mart. Mart BRSPará BRS Pará BRSPA PA (BRS-PA BRSPai Pai dÉgua d Égua BRSPDE PDE (BRS-PDE Amazon progenitors waterdeficit deficit tolerance hypothesis wellwatered well watered (control predawn pre dawn 233 2 33 2.3 MPa. MPa . MPa) CO A (A 82 86 gs (gs 93 87 BRSPA. PA. wateruse use 43 Ags (A/gs 193 44 27 53 16 85 8 5 8.5 conclusion 23 3 2. 9 4 19 1 8.

Resumo As cultivares de açaí (Euterpe oleracea Mart.) BRS-Pará (BRS-PA) e BRS-Pai d’Égua (BRS-PDE) foram selecionadas para cultivo em regiões de terra firme da Amazônia. Como essas cultivares foram desenvolvidas a partir de diferentesprogenitores,nós postulamos que essas cultivares podem diferir na tolerância ao déficithídrico. Para testar essa hipótese, plantas de ambas os cultivares foram avaliadas em condiçõesadequadas de irrigação (controle) e déficit hídrico (potencial hídrico foliar naantemanhã de – 2,33MPa). Em relação ao controle, o déficit hídrico reduziu a taxa de assimilaçãolíquida de CO2(A) e a transpiração, em 82%, e 86% em ambas as cultivares, enquanto acondutância estomática(gs) foi reduzida em 93% e 87%, nas plantas estressadas de BRS-PDE e BRS-PA. O déficit hídrico aumentou a eficiência instantânea do uso da água em 43%, em ambas as cultivares,enquanto a eficiência intrínseca do uso da água (A/gs) aumentou 193% na BRS-PDE e 33% na BRS-PA. O déficit hídrico induziu o aumento de 44% na prolina foliare um decréscimo de 27% nos carboidratos solúveis totais, enquanto a sacarose foliar diminuiu53% na BRS-PA e 16% na BRS-PDE, em relação ao controle. O conteúdo relativo de águanas plantas estressadas de ambas as cultivares diminuiu em 8,5% em relação ao controle. Emconclusão, o controle da abertura estomática mais eficiente e a maior A/gs, na BRS-PDE,indicam que esta cultivar respondeu melhor ao déficit hídrico que a BRS-PA. Euterpe Mart. Mart BRSPará BRS Pará BRSPA PA (BRS-PA BRSPai Pai dÉgua d Égua BRSPDE PDE (BRS-PDE Amazônia diferentesprogenitoresnós diferentesprogenitores nós déficithídrico hipótese (controle potencial 2,33MPa. 233MPa MPa 2,33MPa . 2 33MPa 2,33MPa) CO2A COA CO2 A CO CO2(A transpiração 82 82% 86 estomáticags gs estomática(gs 93 87 87% BRSPA. PA. 43 43% cultivaresenquanto A/gs Ags (A/gs 193 33 44 27 totais diminuiu53 16 BRSPDE, PDE, 85 8 5 8,5 Emconclusão BRSPDE,indicam BRSPDEindicam PDE,indicam indicam 9 4 19 3 diminuiu5 1 8, PDEindicam

Resumo Entre o contínuum lingüístico e cultural galego-portugués hai moito ruído institucional (Torres Feijó e Samartim, 2018) que é preciso silenciar. O ruído é entendido aquí como unha falla na comunicación provocada por un conxunto de obstáculos entre Galiza e Portugal, que traban a fluidez da relación e incluso chegan a impedir esta (cf. Quiroga, 2016). Ou desde unha perspectiva complementar, a identidade galega é sempre posta en causa en Portugal (García González, 2012; Pazos-Justo, 2016, p. 9). Porén, e como dicía Manuel María: “Se ollamos un mapa da península ibérica podemos comprobar que Galiza forma parte da súa cara atlántica. Galiza é, como se dixésemos, a cabeza de Portugal” (María, 2010, p. 14). O meu argumento chave neste texto é que a lingua e a cultura galegas fan parte do sistema lingüístico e cultural galego-portugués, e desenvolverei esta perspectiva culturalista integracionista a partir de un diálogo crítico e dialéctico coa obra de Fernando Venâncio titulada “Assim nasceu uma língua”.

Abstract Between the Galician-Portuguese linguistic and cultural continuum there is a lot of institutional noise (Torres Feijó and Samartim, 2018) that needs to be silenced. The noise is understood here as a failure in communication caused by a set of obstacles between Galicia and Portugal, which block the fluidity of the relationship and even prevent it (cf. Quiroga, 2016). Or from a complementary perspective, Galician identity is always called into question in Portugal (García González, 2012; Pazos-Justo, 2016, p. 9). However, as Manuel María said: "If we look at a map of the Iberian Peninsula, we can see that Galicia is part of its Atlantic side. Galicia is, as we say, the head of Portugal" (María, 2010, p. 14). My key argument in this text is that the Galician language and culture are part of the Galician-Portuguese linguistic and cultural system, and I will develop this integrationist culturalist perspective from a critical and dialectical dialogue with Fernando Venâncio's work entitled "Assim nasceu uma língua" .

Abstract. Recently, there is growing interest in obtaining bioactive compounds from species in the family Cactaceae, which has been little analyzed at the genomic and transcriptomic level. We here report the assembly of the genome of Cereus fernambucensis and we analyzed six cactus genomes (Carnegiea gigantea, Lophocereus schottii, Pachycereus pringlei, Pereskia humboldtii, Selenicereus undatus and Stenocereus thurberi), the annotation of putative genes, and the modeling of the three-dimensional structures of their predicted proteins involved in flavonoid metabolism. We identified genes encoding proteins related to plant pathogenesis (PR-10), coding secuences (CDS) of aldehyde reductase and flavonoid reductase, CDS of enzymes involved in the biosynthesis of phenolic compounds, and ABC transporters. The grouping of the enzymes aspartic proteinase-like protein, flavanone 3-hydroxylase (F3H), hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyl transferase (HCT), and protein serine/threonine- phosphatase was shown to be highly conserved in the genomes of the analyzed cacti. We found divergence of the plant PDR ABC-type transporter family protein (PEN3) in Cereus fernambucensis and the absence in this species of sterol methyltransferase (SMT1). Our three-dimensional modeling of the tertiary structure of F3H from a consensus sequence of cactus species had 88 % identity with that reported in Arabidopsis thaliana. We observed the conservation in several plant species of the 2-oxoglutarate and iron-dependent domain of F3H. This is the first report of an exploration of putative genes encoding enzymes involved in secondary metabolism in cacti species providing information that could be used to improve the production of bioactive compounds in them.

Resumen. Recientemente, ha incrementado el interés en obtener compuestos bioactivos de especies de la familia Cactaceae, que ha sido poco analizada a nivel genómico y transcriptómico. Nosotros reportamos el ensamblaje del genoma Cereus fernambucensis y analizamos además seis genomas de cactus (Carnegiea gigantea, Lophocereus schottii, Pachycereus pringlei, Pereskia humboldtii, Selenicereus undatus y Stenocereus thurberi), la anotación de genes putativos y el modelado de las estructuras tridimensionales de sus proteínas involucradas en el metabolismo de los flavonoides. Se identificaron genes que codifican proteínas relacionadas con la patogénesis vegetal (PR-10), secuencias codificantes (CDS) de aldehído reductasas y flavonoide reductasas, CDS de enzimas implicadas en la biosíntesis de compuestos fenólicos y transportadores ABC. La agrupación de las enzimas similar a la proteinasa aspártica, flavanona 3-hidroxilasa (F3H), hidroxicinamoil-CoA shikimato/quinato hidroxicinamoiltransferasa (HCT) y proteína serina/treonina-fosfatasa demostró estar altamente conservada en los genomas de los cactus analizados. Se encontró divergencia de la proteína (PEN3) de la familia transportadora de tipo ABC PDR en Cereus fernambucensis y la ausencia en esta especie de esterol metiltransferasa (SMT1). Nuestro modelado tridimensional de la estructura terciaria de F3H a partir de una secuencia consenso de especies de cactus tuvo una identidad del 88 % con la reportada en Arabidopsis thaliana. Observamos la conservación en varias especies vegetales del dominio 2-oxoglutarato y dependiente del hierro de F3H. Este es el primer informe de una exploración de genes putativos que codifican enzimas involucradas en el metabolismo secundario en especies de cactus que aporta información que podría usarse para mejorar la producción de compuestos bioactivos.

Abstract Geomorphological studies are crucial for understanding the evolution of relief, and when associated with cartography, they enhance the interpretation and knowledge of environmental dynamics. Hence, historical cartography is essential for the documental rescue of landscapes, which, based on the mapped geoforms, enhances post-discovery studies for the state of Ceará, Brazil. Historically, this state was intermittently mapped in the sixteenth and seventeenth centuries but gained greater attention from Portugal in the eighteenth and nineteenth centuries after its separation from Pernambuco. Despite this, cartographic studies on coastal geoforms are not typical for the Ceará coast over a given period, highlighting the importance of this investigation. Therefore, this article aimed to study the environmental history of the coastal geoforms mapped on the extreme west coast of Ceará in the seventeenth and eighteenth centuries. This research had a qualitative and exploratory basis, with cartographic documental surveys online and in loco, covering the municipalities of Jijoca de Jericoacoara, Camocim, and Barroquinha. Fifty maps of different origins were collected, three of which were used: a French sketch and two Portuguese maps. In the French material of 1615, geoforms in the Cape de la Tortue indicated the presence of a rocky island separated from the mainland. From the Portuguese map of 1629, a well-cut coastline was noted, identifying Buraco das Tartarugas, where there were two islands of different sizes. In the 1794 map, an island in the cove called Geri qua Coá was noted, differing in landscape from the previous ones, as it did not have tombolos connected to the continent. The cartographies presented particularities for revealing a possible advance in the local sea level. Thus, it is possible to motivate future research in the area of historical cartography as a tool for the analysis of the paleogeographic evolution of the coastal zones of Ceará. relief dynamics Hence landscapes postdiscovery post discovery Brazil Historically Pernambuco period investigation Therefore basis loco Jericoacoara Camocim Barroquinha collected used 1615 mainland 1629 wellcut well cut noted Tartarugas sizes 179 ones continent level Thus 161 162 17 16 1

Abstract Fluoride (F) has been widely used to control dental caries, and studies suggest beneficial effects against diabetes when a low dose of F is added to the drinking water (10 mgF/L). Objectives This study evaluated metabolic changes in pancreatic islets of NOD mice exposed to low doses of F and the main pathways altered by the treatment. Methodology In total, 42 female NOD mice were randomly divided into two groups, considering the concentration of F administered in the drinking water for 14 weeks: 0 or 10 mgF/L. After the experimental period, the pancreas was collected for morphological and immunohistochemical analysis, and the islets for proteomic analysis. Results In the morphological and immunohistochemical analysis, no significant differences were found in the percentage of cells labelled for insulin, glucagon, and acetylated histone H3, although the treated group had higher percentages than the control group. Moreover, no significant differences were found for the mean percentages of pancreatic areas occupied by islets and for the pancreatic inflammatory infiltrate between the control and treated groups. Proteomic analysis showed large increases in histones H3 and, to a lesser extent, in histone acetyltransferases, concomitant with a decrease in enzymes involved in the formation of acetyl-CoA, besides many changes in proteins involved in several metabolic pathways, especially energy metabolism. The conjunction analysis of these data showed an attempt by the organism to maintain protein synthesis in the islets, even with the dramatic changes in energy metabolism. Conclusion Our data suggests epigenetic alterations in the islets of NOD mice exposed to F levels comparable to those found in public supply water consumed by humans. (F caries (1 mgFL mgF/L . mgF L mgF/L) treatment total 4 groups 1 weeks period insulin glucagon H Moreover extent acetyltransferases acetylCoA, acetylCoA acetyl CoA, CoA acetyl-CoA metabolism humans (

Abstract Background Diagnostic bioassays are used to screen the suspected R population. They are conducted at a single herbicide dose and evaluated at a specific time after treatment that can differentiate resistant from susceptible population. Objective Three different bioassays were evaluated to assess the detection of acetyl CoA carboxylase-inhibiting herbicides resistance in D. ciliaris. Method Increasing herbicide rates were used to evaluate the three bioassays for differentiating R from S populations. Results R1 and R2 differed from S in all employed bioassays. In the Agar-based gel box box assay, the S biotype had greater plant damage at the lower herbicide concentration relative to the R biotypes 3 DAT but differences between R and S decreased over time. In the leaf flotation assay, R biotypes floated at the lower concentration on the surface, whereas the leaves of S biotypes failed to float. For the electrical conductivity assay, the S biotype contained high electrical conductivity due to the high leaching of electrolyte into the water across all four herbicides tested than the R biotypes. Conclusion While these assays were able to separate R and S biotypes, the level of resistance difference for any assay was no greater than 40% depending on rating data and exposure dose. While a statistical separation could be achieved using a rate response regression analysis for these bioassays, our data highlights the challenges associated whether these methods could provide an obvious difference at any single rate or rating data to be used as a consistent, effective first-phase resistance screen. population carboxylaseinhibiting carboxylase inhibiting D ciliaris populations Agarbased Agar based surface float 40 consistent firstphase first phase 4

ABSTRACT Introduction COVID-19 is associated with endothelial activation and systemic inflammation; consequently, statins can be used in its treatment as they have anti-inflammatory, antithrombotic, and profibrinolytic properties and may interfere with COVID-19 viral entry into cells through disruption of cell membrane lipid rafts. Objective We performed a meta-analysis of randomized clinical trials that compared statin therapy to placebo or to standard care in adult patients hospitalized for COVID-19. Methods We searched the MEDLINE, EMBASE, and Cochrane Library databases for all-cause mortality, hospitalization duration, and admission to the intensive care unit. Results Of the 228 studies reviewed, four studies were included, with a total of 1,231 patients, of whom 610 (49.5%) were treated with statins. There was no significant difference in all-cause mortality (odds ratio [OR] 0.96; 95% confidence interval [95%CI]: 0.61-1.51; p=0.86; I2=13%), duration of hospitalization (mean difference [MD] 0.21; 95%CI: -1.74-2.16; p=0.83; I2=92%), intensive care unit admission (OR= 3.31; 95%CI: 0.13-87.1; p=0.47; I2=84%), need for mechanical ventilation (OR= 1.03; 95%CI: 0.36-2.94; p=0.95; I2=0%), or increase in liver enzyme levels (OR= 0.58; 95%CI: 0.27-1.25; p=0.16; I2=0%) between patients treated with or without statin therapy. Conclusion Our findings suggest that in adult patients hospitalized with COVID-19, statin therapy results in no difference in clinical outcomes when compared to outcomes by placebo or standard of care. Prospero database registration: (www.crd.york.ac.uk/prospero) under the number CRD42022338283. COVID19 COVID 19 COVID-1 inflammation consequently antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory antithrombotic rafts metaanalysis meta analysis COVID19. 19. MEDLINE EMBASE allcause all cause 22 reviewed included 1231 1 231 1,23 61 49.5% 495 49 5 (49.5% odds OR [OR 0.96 096 0 96 95 95%CI 95CI CI [95%CI] 0.611.51 061151 0.61 1.51 51 0.61-1.51 p=0.86 p086 p 86 I2=13%, I213 I I2=13% , I2 13 I2=13%) mean MD [MD 0.21 021 21 1.742.16 174216 1.74 2.16 74 2 16 -1.74-2.16 p=0.83 p083 83 I2=92%, I292 I2=92% 92 I2=92%) OR= (OR 3.31 331 3 31 0.1387.1 013871 0.13 87.1 87 0.13-87.1 p=0.47 p047 47 I2=84%, I284 I2=84% 84 I2=84%) 1.03 103 03 0.362.94 036294 0.36 2.94 36 94 0.36-2.94 p=0.95 p095 I2=0%, I20 I2=0% 0.58 058 58 0.271.25 027125 0.27 1.25 27 25 0.27-1.25 p=0.16 p016 COVID19, 19, registration www.crd.york.ac.uk/prospero wwwcrdyorkacukprospero www crd york ac uk prospero (www.crd.york.ac.uk/prospero CRD42022338283 CRD COVID1 COVID- 123 23 1,2 6 49.5 4 (49.5 0.9 09 9 [95%CI 611 0.611.5 06115 061 0.6 151 1.5 0.61-1.5 p=0.8 p08 8 I21 I2=13 0.2 02 742 1.742.1 17421 174 1.7 216 2.1 7 -1.74-2.1 I29 I2=92 3.3 33 1387 0.1387. 01387 013 0.1 871 87. 0.13-87. p=0.4 p04 I28 I2=84 1.0 10 362 0.362.9 03629 036 0.3 294 2.9 0.36-2.9 p=0.9 p09 I2=0 0.5 05 271 0.271.2 02712 027 125 1.2 0.27-1.2 p=0.1 p01 CRD4202233828 12 1, 49. (49. 0. 0.611. 0611 06 15 1. 0.61-1. p=0. p0 I2=1 1.742. 1742 17 2. -1.74-2. I2=9 3. 138 0.1387 0138 01 0.13-87 I2=8 0.362. 0362 29 0.36-2. I2= 0.271. 0271 0.27-1. CRD420223382 (49 0.611 0.61-1 p=0 1.742 -1.74-2 0.138 0.13-8 0.362 0.36-2 0.271 0.27-1 CRD42022338 (4 0.61- p= -1.74- 0.13- 0.36- 0.27- CRD4202233 ( -1.74 CRD420223 -1.7 CRD42022 -1. CRD4202 -1 CRD420 - CRD42 CRD4

ABSTRACT Objective: To investigate the accuracy of aortic dimensions measured by Revolution™ computed tomography (CT) in infants with complex coarctation of the aorta (CoA) and to further analyze the utility of the degree of CoA in predicting the risk of prolonged postoperative cardiac intensive care unit stay. Methods: A total of 30 infants with complex CoA who underwent surgical correction from January 2020 to July 2022 were retrospectively enrolled. General demographic data, preoperative imaging, and perioperative outcomes were collected. Univariate and multivariate analyses were performed to investigate predictors of prolonged postoperative cardiac intensive care unit stay, and the reliability of the CT measurements was assessed by the intraclass correlation coefficient. Results: All infants were divided into a mild or severe CoA group. The duration of mechanical ventilation and cardiac intensive care unit stay in the mild CoA group were significantly lower than those in the severe CoA group. After multivariate analysis, we found that the degree of CoA and age at surgery were significant predictors of prolonged postoperative cardiac intensive care unit stay. The intraclass correlation coefficient between CT measurements and intraoperative measurements was between 0.937 and 0.975, and the measurement results had good reliability. Conclusion: CT angiography can provide a comprehensive and accurate preoperative evaluation of aortic dimensions measured in infants with complex CoA. The degree of CoA is an independent risk factor for prolonged postoperative cardiac intensive care unit stay in infants with complex CoA. Objective Revolution (CT (CoA Methods 3 202 enrolled data imaging collected Results analysis 0937 0 937 0.93 0975 975 0.975 Conclusion 20 093 93 0.9 097 97 0.97 2 09 9 0.

ABSTRACT Soybean cultivation requires herbicide application in the off-season, before emergence for weed desiccation, and after emergence. It is believed that the use of preand post-emergent herbicides combined with preharvest application may negatively affect the quality of soybean seeds. As such, the present study aimed to assess the effect of preand post-emergent herbicides on soybean seed quality. Five field experiments were conducted during the 2018/2019 and 2019/2020 growing seasons to investigate the effects of synthetic auxins and pre-emergents, acetyl-CoA carboxylase (ACCase) inhibitors, broadleaf herbicides, and s-metolachlor or clomazone on the quality of soybean seeds. Dicamba application combined with the pre-emergent herbicides imazethapyr/flumioxazin before soybean planting reduced seed vigor and germination. ACCase inhibitors in association with broadleaf herbicides before planting had no effect on seed quality. Applying s-metolachlor (up to 2,880 g of active ingredient [ai] ha-1) or clomazone (up to 1,800 g ai ha-1) was safe for seed germination, even when used after soybean emergence. offseason, offseason off season, season off-season desiccation postemergent post emergent seeds such 20182019 2018 2019 2018/201 20192020 2020 2019/202 preemergents, preemergents pre emergents, emergents pre-emergents acetylCoA acetyl CoA (ACCase smetolachlor s metolachlor preemergent imazethapyrflumioxazin imazethapyr flumioxazin germination up 2880 2 880 2,88 [ai ha1 ha 1 ha-1 1800 800 1,80 2018201 201 2018/20 2019202 202 2019/20 288 88 2,8 ha- 180 80 1,8 201820 20 2018/2 201920 2019/2 28 8 2, 18 1, 20182 2018/ 20192 2019/

RESUMO No cultivo da soja, faz-se necessário a aplicação de herbicidas na entressafra, com a associação de herbicidas para a dessecação das plantas-daninhas com pré-emergentes, bem como com aplicações em pós-emergência da soja. Acredita-se que herbicidas aplicados na dessecação pré-semeadura soja, em associação com herbicidas pré-emergentes, bem como herbicidas pré-emergentes aplicados em pós-emergência da soja, possam afetar negativamente a qualidade de sementes da cultura. Assim, objetivouse com este estudo avaliar o efeito de herbicidas, aplicados em pré ou pós-emergência da soja, na qualidade de sementes produzidas. Foram conduzidos cinco experimentos no campo, durante as safras 2018/2019 e 2019/2020. Foram investigados os efeitos de auxinas sintéticas e pré-emergentes, inibidores da ACCase e latifolicidas, e smetolachlor ou clomazone sobre a qualidade de sementes produzidas. A aplicação de dicamba em associações com os herbicidas préemergentes imazethapyr/flumioxazin, em pré-semeadura da soja, diminuiu o vigor e germinação das sementes. A aplicação de herbicidas inibidores da ACCase em associação com latifolicidas, em pré-semeadura, não teve impacto sobre a qualidade das sementes. A aplicação de s-metolachlor (até 2.880 g de ingrediente ativo [ia] ha-1) ou de clomazone (até 1.800 g ia ha-1) foi segura para a germinação das sementes, mesmo para a aplicação em pós-emergência da cultura. soja fazse faz se entressafra plantasdaninhas plantas daninhas préemergentes, emergentes, emergentes pósemergência pós emergência Acreditase Acredita présemeadura semeadura cultura Assim produzidas campo 20182019 2018 2019 2018/201 20192020 2020 2019/2020 latifolicidas imazethapyrflumioxazin imazethapyr flumioxazin imazethapyr/flumioxazin présemeadura, semeadura, s metolachlor até 2880 2 880 2.88 [ia ha1 ha 1 ha-1 1800 800 1.80 2018201 201 2018/20 2019202 202 2019/202 288 88 2.8 ha- 180 80 1.8 201820 20 2018/2 201920 2019/20 28 8 2. 18 1. 20182 2018/ 20192 2019/2 2019/