We report a facile hydrothermal method for the synthesis of niobium pentoxide (Nb2O5) under two different temperatures, 120 °C (Nb2O5-120) and 150 °C (Nb2O5-150). The obtained materials were characterized by structural, optical and morphological techniques. Also, the photocatalytic properties of the Nb2O5 samples were evaluated in two reactions under ultraviolet (UVC) irradiation: degradation of methylene blue (MB) and indigo carmine (IC) dyes; and esterification of free fatty acids (FFA) present in waste cooking oil (WCO). The Nb2O5 was formed at different temperatures of synthesis, and the increase in temperature did not cause significant changes in the structural and optical characteristics, but resulted in an increased surface area of the synthesized materials. Both synthesized materials showed excellent efficiency for dye photodegradation. The sample Nb2O5-150 presented the best performance for the MB photodegradation, with almost 85% of the removal efficiency. In this case, the adsorption of MB molecules on the surface of the material was high due to the favorable electrostatic interaction and also because of its high surface area. For the IC photodegradation, the adsorption was insignificant, and both samples presented approximately 100% of the removal efficiency. These materials were also promising for the reduction of free fat acids in waste oil by photoesterification. NbO Nb O (Nb2O5 12 C Nb2O5120 (Nb2O5-120 15 Nb2O5150. Nb2O5150 . (Nb2O5-150) techniques Also Nb2O UVC (UVC irradiation (MB (IC dyes FFA (FFA WCO. WCO (WCO) characteristics photodegradation Nb2O5-15 85 case insignificant 100 photoesterification (Nb2O 1 Nb2O512 (Nb2O5-12 Nb2O515 (Nb2O5-150 (WCO Nb2O5-1 8 10 Nb2O51 (Nb2O5-1 (Nb2O5-15 Nb2O5- (Nb2O5-

RESUMO Objetivo: Identificar e caracterizar a população de casos pediátricos encaminhados para o nosso centro de oxigenoterapia hiperbárica. Métodos: Estudo retrospetivo e observacional, que incluiu doentes pediátricos tratados com oxigenoterapia hiperbárica, de 2006 a 2021, no centro de referência de medicina hiperbárica do norte de Portugal. As variáveis de interesse foram extraídas dos processos clínicos eletrônicos. Resultados: O nosso estudo incluiu 134 casos. Os motivos de encaminhamento mais frequentes foram intoxicação por monóxido de carbono (n=59) e surdez súbita neurossensorial (n=41). Em 75 casos (56%) o tratamento foi iniciado em contexto de urgência. Os sintomas de apresentação à admissão variaram entre os diferentes casos, sendo os mais frequentes cefaleias e náuseas/vômitos. No que diz respeito à intoxicação por monóxido de carbono, as fontes mais comuns foram o aquecedor, lareira/braseiro e caldeira. Com relação aos efeitos adversos, foram identificados um caso de intoxicação por oxigênio e quatro casos de barotrauma do ouvido médio. Conclusões: A causa mais frequente de encaminhamento foi a intoxicação por monóxido de carbono. Todos os pacientes evoluíram favoravelmente e foram registrados poucos efeitos adversos, o que enfatiza a segurança desta terapia. Uma vez que a maioria dos pediatras pode não estar informada sobre os potenciais benefícios da oxigenoterapia hiperbárica, é de extrema importância promovê-los para que esta técnica seja cada vez mais implementada. Objetivo Métodos observacional 200 2021 Portugal eletrônicos Resultados 13 n=59 n59 n 59 (n=59 n=41. n41 n=41 . 41 (n=41) 7 56% 56 (56% urgência náuseasvômitos náuseas vômitos náuseas/vômitos aquecedor lareirabraseiro lareira braseiro caldeira adversos médio Conclusões terapia promovêlos promovê los implementada 20 202 1 n=5 n5 5 (n=5 n4 n=4 4 (n=41 (56 2 n= (n= (n=4 (5 (n (

ABSTRACT Objective: To identify and characterize the population of Pediatric patients referred to our hyperbaric oxygen therapy center. Methods: Retrospective and observational study, including pediatric patients treated with hyperbaric oxygen therapy, from 2006 to 2021, at the hyperbaric medicine reference center in the north of Portugal. Variables of interest were extracted from electronic medical records. Results: Our study included 134 patients. The most frequent reasons for referral were carbon monoxide poisoning (n=59) and sudden sensorineural hearing loss (n=41). In 75 cases (56%), treatment was initiated in an urgent context. Symptom presentation at Emergency Department varied among patients, the most frequent being headache and nausea/vomiting. Concerning carbon monoxide poisoning, the most common sources were water heater, fireplace/brazier, and boiler. Regarding adverse effects, it was identified one case of intoxication by oxygen and four cases of middle ear barotrauma. Conclusions: The most frequent cause for referral was carbon monoxide poisoning. All patients evolved favorably, with few side effects being reported, emphasizing the safety of this therapy. While most pediatricians may not be aware of the potential benefits arising with hyperbaric oxygen therapy, it is of upmost importance to promote them, so that this technique is increasingly implemented. Objective Methods 200 2021 Portugal records Results 13 n=59 n59 n 59 (n=59 n=41. n41 n=41 . 41 (n=41) 7 56%, 56 56% , (56%) context nauseavomiting nausea vomiting nausea/vomiting heater fireplacebrazier fireplace brazier fireplace/brazier boiler barotrauma Conclusions favorably reported them implemented 20 202 1 n=5 n5 5 (n=5 n4 n=4 4 (n=41 (56% 2 n= (n= (n=4 (56 (n (5 (

ABSTRACT: The study of genotypic relationships between drought tolerance indices and agronomic traits of interest in wheat breeding is useful for designing selection strategies. The objective of this research was to investigate the cause-and-effect relationships between agronomic traits and drought tolerance indices through the analysis of canonical correlations. Two trials (control and stress) were conducted in winter 2020 in Viçosa, MG, Brazil. The traits evaluated were: (days for heading, plant height, mass and number of grains per spike, mass of one hundred grains, and grain yield). Grain yield data from the control and stress conditions were used to construct five drought tolerance indices. The data were subjected to mixed model analysis for estimation of genetic parameters and prediction of genotypic values (REML/BLUP), and then the genotypic values were used to calculate the correlation coefficients between the traits. Two groups of traits were established for the study of canonical correlations, the first group consisting of agronomic traits and the second by drought tolerance indices. There was a significant genotype effect for all evaluated traits. The canonical pairs were significant, which indicated the existence of dependence between the groups. Days to heading trait can be used in the indirect selection of wheat genotypes for drought tolerance. ABSTRACT strategies causeandeffect cause correlations 202 Viçosa MG Brazil days height spike yield. . yield) REML/BLUP, REMLBLUP REML/BLUP , REML BLUP (REML/BLUP) 20 (REML/BLUP 2

RESUMO: O estudo das relações genotípicas entre índices de tolerância à seca e caracteres agronômicos de interesse no melhoramento de trigo é útil para traçar estratégias de seleção. Objetivou-se com este trabalho investigar as relações de causa e efeito entre características agronômicas e índices de tolerância à seca via análise de correlações canônicas. Dois ensaios (controle e estresse) foram conduzidos no inverno de 2020 em Viçosa, MG, Brasil. Foram avaliados os caracteres (dias para o espigamento, altura da planta, massa e número de grãos por espiga, massa de cem grãos e rendimento de grãos). Os dados de produtividade dos ensaios de controle e estresse foram utilizados para construir cinco índices de tolerância à seca. Os dados foram submetidos à análise de modelos mistos para estimação dos parâmetros genéticos e predição dos valores genotípicos (REML/BLUP), em seguida, os valores genotípicos foram utilizados para calcular os coeficientes de correlação entre os caracteres. Dois grupos de caracteres foram estabelecidos para o estudo das correlações canônicas, sendo o primeiro grupo constituído pelas variáveis agronômicas e o segundo pelos índices de tolerância à seca. Houve efeito significativo de genótipo para todas as características avaliadas. Os pares canônicos foram significativos, o que indicou a existência de dependência entre os grupos. O caráter dias para o espigamento pode ser utilizado na seleção indireta de genótipos de trigo para tolerância à seca. RESUMO Objetivouse Objetivou se canônicas 202 Viçosa MG Brasil planta espiga grãos. . grãos) REML/BLUP, REMLBLUP REML/BLUP , REML BLUP (REML/BLUP) seguida avaliadas significativos 20 (REML/BLUP 2

Considering the cytotoxic properties of Schiff base ligands, we re-synthesized a gold(III) complex with a tetradentate Schiff base ligand and investigated its cytotoxic effects using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method and sulforhodamine B staining method. The results showed that the gold(III) Schiff base complex can inhibit the growth of Chinese hamster ovary (CHO) cancer cell lines. However, unlike cisplatin, it does not induce cell death in NIH 3T3 normal cells. Real-time polymerase chain reaction (PCR) results revealed that the gold(III) Schiff base complex increased the Bak1/Bclx ratio in CHO cell line by 3.53-fold compared to the control, while cisplatin increased the anti-apoptotic Bclx gene by 31.8 times and the treatment resistance AKT1 gene by 430.8 times the control. However, cisplatin only activated the extrinsic pathway of apoptosis through the caspase-3 gene. The expression levels of TLR6 and TNF-α genes in normal cells showed that both the gold(III) Schiff base complex and cisplatin did not cause inflammation in NIH 3T3 cell lines. All the results indicate that the new complex could be a promising candidate to replace cisplatin. It has been shown that it induces apoptosis and prevents the development of resistance in cancer cells. Additionally, it does not cause inflammation in normal cells. ligands resynthesized re synthesized goldIII gold III gold(III 34,5dimethylthiazol2yl2,5diphenyltetrazolium 345dimethylthiazol2yl25diphenyltetrazolium dimethylthiazolyldiphenyltetrazolium 3 4,5 dimethylthiazol 2 yl 2,5 diphenyltetrazolium 4 5 bromide (CHO lines However T 3T Realtime Real time PCR (PCR Bak1Bclx BakBclx Bak1 Bak 3.53fold 353fold fold 3.53 53 control antiapoptotic anti apoptotic 318 31 8 31. AKT 4308 430 430. caspase3 caspase caspase- TLR TNFα TNF α Additionally 34 5dimethylthiazol2yl2 5diphenyltetrazolium 45 4, 25 2, 53fold 353 3.5 43 dimethylthiazolyl 5dimethylthiazol2yl 35 3.

ABSTRACT Optic neuritis is an important cause of unilateral and acute visual loss in young adults, but other differential diagnoses should be considered, especially when the disease has an atypical presentation. This report presents the case of a young woman with reduced visual acuity in her right eye, associated with optic disc edema and a relative afferent pupillary defect, that was initially misdiagnosed as optic neuritis and subsequently found to have paracentral acute middle maculopathy, possibly secondary to subtle impending central retinal vein occlusion. This case emphasizes the need to remember that retinal vascular diseases can occasionally mimic optic neuritis. Detailed anamnesis and ophthalmic examination can avoid unnecessary interventions. adults considered presentation eye defect maculopathy occlusion interventions

Iron is an important ion that regulates many metabolic functions in the human body, and its deficiency or overload can cause serious health problems. In view of this, the development of tools that can quantify iron in aqueous media is quite valuable. A new material based on a metal-organic framework (MOF) and a calixarene derivative (CALIX), here named CALIX@UiO-66-NH2, was successfully prepared and used as a luminescent sensor for iron ions in a water matrix containing various metal ions. The post-synthetic modification was demonstrated to be efficient on the MOF (UiO-66-NH2) modification, leading to a hybrid platform. The effect of the combination of both components (MOF and CALIX) led to a platform more sensitive to iron detection than the independent compounds. The CALIX@UiO-66-NH2 sensor shows a linear response toward Fe3+ ions with satisfactory linearity (R2 = 0.994) within the concentration range of 6.74 × 10−6−1.72 × 10−5 mol L−1. The limit of detection was determined to be as low as 1.6 mg L−1. The data demonstrate that CALIX@UiO-66-NH2 is an excellent probe for detecting Fe3+, as confirmed by almost complete fluorescence suppression. body problems this valuable metalorganic organic CALIX, CALIX , (CALIX) CALIX@UiO66NH2, CALIXUiO66NH2 CALIXUiONH CALIX@UiO 66 NH2, UiO NH2 NH postsynthetic post synthetic UiO66NH2 UiONH (UiO-66-NH2 compounds CALIX@UiO66NH2 CALIX@UiO-66-NH Fe3 Fe R2 R (R 0.994 0994 0 994 674 6 74 6.7 106172 10 1 72 10−6−1.7 105 5 10− L1 L L−1 16 1. suppression (CALIX CALIXUiO CALIXUiO66NH UiO66NH (UiO-66-NH CALIX@UiO66NH 0.99 099 99 67 7 6. 10617 10−6−1. L− 0.9 09 9 1061 10−6−1 0. 106 10−6− 10−6

Phosphate species can affect aquatic ecosystems, as excess of this nutrient can cause eutrophication, generating environmental impacts. Lamellar double hydroxides have shown promise in removing phosphate at low concentrations (10-50 mg L 1). In this context, lamellar double hydroxides were synthesized interspersed with nitrates and humic substances, searching for a new product that favors phosphorus adsorption. X-ray diffraction showed the presence of characteristic peaks of lamellar double hydroxides and thermogravimetric analysis showed the decomposition behavior of lamellar structure. The adsorption capacity occurred quickly (< 30 min), being more efficient for lamellar double hydroxides with NO3. The maximum adsorption capacity showed results of 35.03 and 44.20 mg g 1 for lamellar double hydroxides with humic substances and lamellar double hydroxides with NO3, respectively. The complexation capacity showed that pH directly influences complexation, being greater for lamellar double hydroxides with humic substances at pH 6.5. Thus, nanostructured materials with humic substances are promising for use in contaminant remediation and adsorption can be a fast and efficient technique for use in soil and water. ecosystems eutrophication impacts 1050 10 50 (10-5 1. . 1) context Xray X ray structure < ( 3 min, min , min) NO3 NO 3503 35 03 35.0 4420 44 20 44.2 respectively 65 6 5 6.5 Thus water 105 (10- 350 0 35. 442 4 2 44. 6. (10 (1

Resumen Marco contextual: El contexto de la enseñanza clínica y la experiencia de la pandemia de COVID-19 son factores potencialmente estresantes y/o ansiógenos para los estudiantes de enfermería. Objetivo: Evaluar la eficacia del programa “Aprender a Relajarse” para reducir el estrés y la ansiedad en estudiantes de enfermería. Metodología: Estudio longitudinal preexperimental con una muestra de siete estudiantes a los que se les hizo un seguimiento en la clínica de ansiedad. Diseño y aplicación del programa “Aprender a Relajarse”, basado en técnicas de respiración diafragmática y relajación muscular progresiva, con ocho sesiones a lo largo de cinco semanas. Evaluación inicial, final y de seguimiento mediante la Escala de Percepción del Estrés y el Cuestionario de Autoevaluación de la Ansiedad de Zung. Resultados: Reducción de los niveles de estrés entre la evaluación inicial y la final (p = 0,069) y disminución significativa entre la evaluación inicial y el follow-up (p = 0,033). Disminución significativa de la ansiedad entre la evaluación inicial y la final (p = 0,033) y entre la evaluación inicial y el follow-up (p = 0,006). Conclusión: Programa mostró un efecto positivo sobre la gestión del estrés, el autocontrol de la ansiedad y los síntomas asociados, lo que lo convierte en un recurso terapéutico útil para la intervención con estudiantes de enfermería.

Resumo Enquadramento: O contexto de ensino clínico e a vivência da pandemia COVID-19 são potencialmente stressores e/ou ansiogénicos em estudantes de enfermagem. Objetivo: Avaliar a eficácia do programa “Aprender a Relaxar” na redução do stresse e ansiedade em estudantes de enfermagem. Metodologia: Estudo pré-experimental, longitudinal, com amostra de sete estudantes seguidos na consulta de ansiedade. Concebido e implementado Programa “Aprender a Relaxar” baseado nas técnicas de respiração diafragmática e relaxamento muscular progressivo, com oito sessões, em cinco semanas. Avaliação inicial, final e follow-up utilizada Escala de Perceção de Stresse e Questionário de Autoavaliação de Ansiedade de Zung. Resultados: Redução dos níveis de stresse entre avaliação inicial e avaliação final (p = 0,069) e diminuição significativa entre avaliação inicial e follow-up (p = 0,033). Diminuição significativa da ansiedade entre avaliação inicial e avaliação final (p = 0,033) e entre avaliação inicial e follow-up (p = 0,006). Conclusão: Programa demonstrou efeito positivo na gestão do stresse, autocontrolo da ansiedade e sintomatologia associada, sendo um recurso terapêutico útil na intervenção com estudantes de enfermagem.

Abstract Background: Clinical placements and the COVID-19 pandemic are experiences that cause stress and anxiety in nursing students. Objective: To assess the effectiveness of the ‘‘Learning to Relax’’ (Aprender a relaxar) program in reducing stress and anxiety in nursing students. Methodology: A pre-experimental, longitudinal study was conducted with seven students who sought an anxiety consultation. The ‘‘Learning to Relax’’ program was designed based on diaphragmatic breathing and progressive muscle relaxation techniques and implemented in eight sessions during five weeks. The evaluation was conducted at baseline, endline, and follow-up using the Perceived Stress Scale and the Zung Self-Rating Anxiety Scale. Results: Stress levels were lower between baseline and endline (p = 0.069) and significantly lower between baseline and follow-up (p = 0.033). There was a significant decrease in anxiety between baseline and endline (p = 0.033) and between baseline and follow-up (p = 0.006). Conclusion: Program had a positive impact on managing stress, anxiety, and associated symptoms. It is therefore a therapeutic resource for interventions with nursing students.

ABSTRACT Introduction/framework/objectives Multiple Sclerosis has a reasonable prevalence and the diagnosis is generally made at working age, at a stage that is still demanding on a professional level, a time when there are also generally personal/family particularities that require some dedication. Furthermore, given the incidence, diversity and severity of the symptoms presented, limitations often arise that can seriously affect the ability to work or even lead to unemployment. It is then desirable that the members working in Occupational Health and Safety teams have some knowledge on the subject, in order to better guide their performance, safeguarding the interests of everyone involved. Methodology This is a Bibliographic Review, initiated through a search carried out in April 2023, in the databases “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina and RCAAP”. Content It is a demyelinating and autoimmune disease of the Central Nervous System; it is characterized by recurrent and intermittent episodes of inflammation, with generally progressive destruction of axonal myelin. In most cases there is a cycle of relapses and remissions and symptoms of varying intensity; the evolution is unpredictable. Causes autonomic, visual, motor and sensory symptoms; which makes independent daily living and the ability to work difficult; sometimes becoming debilitating. It is incurable and neurodegenerative. The severity varies depending on the neurological areas most affected. The function of myelin is to facilitate conduction at the level of axons; with changes in this, the electrical impulses that coordinate mental and physical functions become less effective. As myelin deteriorates, it is replaced by scars of abnormal tissue, with different consistency (stiffness, plaques), which further disrupts conduction. Injuries to the frontal and parietal lobes often result in cognitive and emotional changes; in the spinal cord, problems arise more easily in the lower limbs. Changes in the optic nerve and occipital lobe can cause visual problems. This is the neurological desease that causes most limitations in the young adult active population. Given the reasonably young age at which symptoms begin, there will be a decrease in quality of life, more significant than in other chronic diseases. Discussion and Conclusions Although the bibliography is not scarce, the emphasis in the vast majority of articles is not on Occupational Health or Safety. It would be relevant for some teams working in large companies with some prevalence, to evaluate the cases in detail, describing the main problems detected, proposed measures and their subsequent evaluation, in order to publish not only the path, but also the conclusions obtained, for greater dissemination of the subject.

RESUMO Introdução/enquadramento/objetivos A Esclerose Múltipla tem uma prevalência razoável e o diagnóstico faz-se geralmente em idade ativa, numa fase ainda exigente a nível profissional, altura essa onde geralmente também existem particularidades pessoais/familiares que necessitam de alguma dedicação. Para além disso, dada a incidência, diversidade e gravidade dos sintomas apresentados, com frequência surgem limitações que podem condicionar seriamente a capacidade de trabalho ou até levar ao desemprego. Será então desejável que os elementos a exercer em equipas de Saúde e Segurança Ocupacionais tenham alguns conhecimentos sobre o tema, de forma a melhor orientar o seu desempenho, salvaguardando os interesses de todos os envolvidos. Metodologia Trata-se de uma Revisão Bibliográfica, iniciada através de uma pesquisa realizada em abril de 2023, nas bases de dados “CINALH plus with full text, Medline with full text, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cochrane Methodology Register, Nursing and Allied Health Collection: comprehensive, MedicLatina e RCAAP”. Conteúdo É uma doença desmielinizante e auto-imune do Sistema Nervoso Central; carateriza-se por episódios recorrentes e intermitentes de inflamação, com destruição de mielina axonal, geralmente progressiva. Na maioria dos casos existe um ciclo de relapsos e remissões e sintomas de intensidade oscilante; a evolução é imprevisível. Causa sintomas autonómicos, visuais, motores e sensoriais; o que dificulta a vida quotidiana independente e o trabalho, tornando-se por vezes debilitante. É incurável e neurodegenerativa. A gravidade varia com as áreas neurológicas mais atingidas. À medida que a mielina se detiora, ela é substituída por cicatrizes de tecido anormal, com diferente consistência (rigidez, placas), o que perturba ainda mais a condução. Lesões nos lóbulos frontal e parietal geralmente resultam em alterações cognitivas e emocionais; na espinal medula, mais facilmente surgem problemas nos membros inferiores. Alterações no nervo ótico e lobo occipital podem originar alterações visuais. Trata-se da doença neurológica que mais limitações causa na população ativa jovem adulta. Dada a idade razoavelmente jovem do início de sintomas, irá ocorrer diminuição da qualidade de vida, mais significativa que noutras doenças crónicas. Discussão e Conclusões Ainda que a bibliografia não seja escassa, a enfase da grande maioria dos artigos não é dada à Saúde ou Segurança Ocupacionais. Seria relevante que algumas equipas a exercer em empresas grandes e com alguma incidência, avaliassem com detalhe os casos, descrevendo os principais problemas detetados, medidas propostas e avaliação posterior das mesmas, de forma a publicar não só o caminho, mas também as conclusões obtidas, para maior divulgação do assunto.

ABSTRACT Introduction: Burnout results from chronic exposure to work-related stress and it is characterized by a reduction in professional efficacy, feelings of lack of energy/exhaustion, and negativity related to work activities. It has a higher incidence in professions with significant interpersonal contact and among caregivers, making doctors a vulnerable population. The Maslach Burnout Inventory questionnaire is considered the gold standard for measuring this disease. In 2014, quinquennial prevention was described, aiming to prevent harm to patients through strategies that reduce Burnout in doctors. Clinical Case: The case describes a 29-year-old woman, a physician in her final year of Residency in General and Family Medicine, who sought an urgent consultation due to feelings of physical and mental exhaustion, hopelessness, irritability, initial and middle insomnia, for the last three months, and hyperphagia, two months ago. She has requested a sick leave from work because “I can't stand working anymore. I need to sleep for a week”. She identified excessive workload at the Clinic, stemming from the demands of her medical residency, as the main cause. She feels unsupported by her colleagues and Training Supervisor and feels pressured to manage the medical agenda without adequate preparation. She reports occasional errors in prescriptions, leading her to feel the need to repeatedly review records and decisions she has made. She denies any appointment with her designated Work physician ever since she started her internship. Upon physical examination, she appeared slaughtered, with a depressed mood, tearful, restless, and with fleeting eye contact. Applying the Maslach Burnout Inventory: Section A- 34 points- high level; Section B- 28 points- high level; Section C- 25 points- high level. A work leave from work was issued, laboratory studies were requested, and fluoxetine 20 mg and trazodone 50 mg were initiated, along with psychotherapy. So far, the patient has been re-evaluated in three consultations, with organic causes ruled out, and in the last re-evaluation, her scores were: Section A- 20 points- moderate level; Section B- 5 points- low level; Section C- 39 points- moderate level. She reports a decrease in medical errors. She maintained the prescribed medication and psychotherapy. She declined to join a Balint group. A new re-evaluation was scheduled in six months. Discussion/Conclusion: This is a case of a General and Family Medicine Resident Physician, diagnosed with Burnout, who has managed to substantially improve her quality of life and job satisfaction, as well as her personal life, following the implementation of both pharmacological and non-pharmacological measures, along with workplace adjustments and the setting of boundaries. She has successfully reduced her perception of making medical errors, thereby improving the quality of healthcare provided to the patients. The long journey of recovery from Burnout makes the monitoring of this illness imperative not only by the patients Family Doctor and Psychologist, but also by the Occupational physician, targeting the improvement of the quality of life of the healthcare professionals in their occupational activity. This clinical case’s purpose is to address and raise awareness among professionals to the prevention of Burnout, particularly in Residents, promoting quinquennial prevention. It is important to note that only professionals who are fulfilled in their biopsychosocial sphere can provide quality care and significantly reduce medical errors.

RESUMO Introdução: O Burnout resulta da exposição crónica ao stress laboral e caracteriza-se por redução da eficácia a nível profissional, sentimentos de falta de energia/exaustão e negatividade relacionados com a atividade laboral. Tem maior incidência em profissões de elevado contacto com pessoas e em prestadores de cuidados, tornando os médicos uma população vulnerável. O questionário Maslach Burnout Inventory é considerado gold standard para a medição desta patologia. Em 2014 foi descrita a prevenção quinquenária, que pretende evitar o dano para o paciente, atuando no médico através de estratégias que visem a diminuição do Burnout. Caso Clínico: Descreve-se uma mulher de 29 anos, médica, no último ano da especialização em Medicina Geral e Familiar, que recorreu a consulta aberta por sensação de exaustão física e mental, sentimentos de desesperança, irritabilidade, insónia inicial e intermédia, com três meses de evolução e hiperfagia há dois meses. Solicitou certificado de incapacidade temporária para o trabalho, porque “já não aguento mais trabalhar. Preciso de dormir uma semana”. Aponta como principal etiologia o trabalho excessivo no Centro de Saúde, decorrente da exigência do internato médico. Sente-se pouco apoiada pelos colegas de equipa e orientador de formação e considera-se pressionada a gerir a agenda médica sem ter preparação para tal. Relata erros pontuais na prescrição médica, pelo que sente necessidade de rever várias vezes os registos efetuados e as atitudes tomadas. Nega ter sido convocada para qualquer consulta de Medicina do Trabalho desde que ingressou na especialidade. Ao exame objetivo, apresentava-se cabisbaixa, com humor deprimido, chorosa, inquieta e com contacto ocular fugaz. Aplicando o questionário atrás mencionado: Secção A - 34 pontos - nível elevado; Secção B - 28 pontos - nível elevado; Secção C - 25 pontos - nível elevado. Foi emitido o certificado de incapacidade temporária para o trabalho, solicitado estudo analítico e iniciada fluoxetina 20mg e trazodona 50mg, bem como psicoterapia. Até à data, a doente foi reavaliada em três consultas, foi excluída patologia orgânica e na última reavaliação apresentava os seguintes valores: Secção A- 20 pontos- nível moderado; Secção B- 5 pontos- nível baixo; Secção C- 39 pontos- nível moderado. Refere diminuição dos erros médicos. Manteve a medicação instituída, bem como a psicoterapia. Recusou o grupo Balint. Foi programada nova reavaliação em seis meses. Discussão/Conclusão: Trata-se de uma doente, Médica Interna em Medicina Geral e Familiar com o diagnóstico de Burnout, que conseguiu melhorar substancialmente a sua qualidade de vida e satisfação no trabalho e vida pessoal, após a implementação de medidas farmacológicas e não farmacológicas e também após alterações a nível laboral e imposição de limites. Conseguiu diminuir a perceção de erro médico, melhorando assim os cuidados de saúde prestados aos utentes. O longo percurso de recuperação desta doença torna fulcral o acompanhamento destes utentes pela equipa de Medicina do Trabalho, e não só pelo Médico de Família e Psicólogo, visando melhorar a qualidade de vida e saúde dos profissionais no âmbito da sua atividade laboral. Com este caso clínico pretende-se abordar e sensibilizar os profissionais para a prevenção do Burnout, em particular nos médicos internos, fomentando a prevenção quinquenária. De ressalvar que apenas profissionais realizados na sua esfera biopsicossocial conseguem proporcionar cuidados de qualidade e reduzir de forma importante o erro médico.

ABSTRACT Although faba-bean (Vicia faba L.) is not a major crop in China, many farmers like to cultivate faba-bean in autumn as a fresh food or animal feed for next spring. However, no herbicides are available to control weeds in the faba-bean fields. Although prosulfocarb is a candidate herbicide, some farmers have reported that prosulfocarb can often cause harm to faba-bean. Our laboratory experiment results revealed that Tongcanxian No. 6, a faba-bean cultivar with large seeds, showed the lowest level of growth inhibition and Qidou No. 2, a faba-bean cultivar with small seeds, showed the highest level of growth inhibition when treated with 3960 and 7920 g ai ha-1 prosulfocarb. The growth inhibition rate of faba-bean was 0% when 3960 and 7920 g ai ha-1 prosulfocarb was sprayed within 6 d after sowing, indicating that prosulfocarb treatment should be applied as soon as possible after sowing. When the temperature exceeded 20 °C and soil moisture content exceeded 20%, it might have aggravated the phytotoxicity of ‘Tongcanxian No. 6’ and ‘Qidou No. 2’ caused by prosulfocarb. Two round of field experiments showed visually that the control effect of 3960 g ai ha-1 prosulfocarb on the total weeds exceeded 90% and safe to faba-bean at the same time. This study indicated that prosulfocarb can be safely used in faba-bean fields by improving agronomic methods, which can also provide a reference for weed management in faba-bean fields worldwide.

ABSTRACT Introduction: the two conditions that cause blindness and that can frequently coexist in the same patient are glaucoma and cataract. Cataract surgery plus trabeculectomy is very useful in Latin American countries due to its good visual results and low cost for patients with limited economic resources. Being a cost-effective alternative for this type of population. Objective: to describe the results of small incision cataract surgery combined with trabeculectomy in patients with glaucoma refractory to maximum therapy at Fundación Visión. Methodology: a retrospective observational study was carried out that included patients who underwent combined cataract and glaucoma surgery at Fundación Visión from May 2021 to April 30, 2022. The following variables were analyzed; visual acuity, intraocular pressure (IOP), number of hypotensive medications, pre and post surgery, in addition to operative complications. Results: before surgery, 51 % of patients had an IOP between 21 to 30 mmHg, and 57 % used triple drug therapy. After surgery, 98 % of patients had IOP <20 mmHg and 41 % did not need to use hypotensive medications. IOP was significantly reduced (p <0.001) from 28.59 mmHg pre-surgery to 11.18 mmHg post-surgery. In 41% of patients (n = 21) the success was complete, in 57% (n = 29) the success was partial and in one patient there was no success. There was only one case of intraoperative complication with zonulodialysis and the postoperative complications were choroidal detachment and flat bulla, with two cases each. Conclusion: small-incision cataract surgery combined with trabeculectomy is a safe, effective, and lower-cost treatment for people suffering from cataract and glaucoma.

RESUMEN Introducción: las dos condiciones que causan ceguera y que pueden frecuentemente coexistir en el mismo paciente son glaucoma y catarata. La cirugía de catarata más trabeculectomía es de gran utilidad en países de América Latina por los buenos resultados visuales y el bajo costo para pacientes de escasos recursos económicos. Siendo una alternativa costo efectiva para este tipo de población. Objetivo: describir los resultados de la cirugía de catarata por pequeña incisión combinada con trabeculectomía en pacientes con glaucoma refractario a terapia máxima en la Fundación Visión. Métodología: se realizó un estudio observacional retrospectivo que incluyó a pacientes intervenidos con una cirugía combinada de catarata y glaucoma en la Fundación Visión de mayo del 2021 al 30 de abril del 2022. Se analizaron las siguientes variables; agudeza visual, presión intraocular (PIO), número de medicamentos hipotensores, pre y post cirugía, además de las complicaciones operatorias. Resultados: previo a la cirugía, el 51 % de los pacientes tenía una PIO entre 21 a 30 mmHg, y el 57 % usaba una triple terapia medicamentosa. Posterior a la cirugía, el 98 % de los pacientes presentaron PIO <20 mmHg y el 41 % no necesitó usar medicamentos hipotensores. La PIO se redujo significativamente (p <0.001) de 28,59 mmHg en la pre cirugía a 11,18 mmHg en la post cirugía. En el 41 % de los pacientes (n = 21) el éxito fue completo, en el 57 % (n = 29) éxito fue parcial y en un paciente no hubo éxito. Solo hubo un caso de complicación intraoperatoria con zonulodiálisis y las complicaciones postoperatorias fueron el desprendimiento coroideo y ampolla plana, con dos casos cada uno. Conclusión: la cirugía de catarata por incisión pequeña combinada con trabeculectomía es un tratamiento seguro, eficaz y de menor costo para personas que padecen catarata y glaucoma.

ABSTRACT Exfoliative dermatitis is a severe cutaneous inflammatory syndrome characterized by generalized erythema and scaling over more than 90 % of the body. This syndrome can be the final stage of various dermatological diseases or the beginning of certain pathologies such as psoriasis, which is the most common cause. Febrile illnesses are cause of psoriasis exacerbations. It is believed that the virus acts as a superantigen and activates cellular immunity causing immunological changes with varied symptoms in predisposed individuals. We present the case of a male patient who presented with a severe form of psoriasis after chikungunya infection.

RESUMEN La eritrodermia es un síndrome inflamatorio cutáneo grave que se caracteriza por eritema y descamación generalizada en más del 90 % del cuerpo. Este síndrome puede ser la etapa final de diversas enfermedades dermatológicas o el inicio de ciertas patologías como la psoriasis, que es la causa más común. Las enfermedades febriles son causa de exacerbaciones de psoriasis. Se cree que el virus actúa como un superantígeno y activa la inmunidad celular causando cambios inmunológicos con clínica variada en individuos predispuestos. Presentamos el caso de un paciente de sexo masculino que debuta con una forma grave de psoriasis posterior a infección por chikungunya.

Abstract This study investigated the effects caused by the thermal shock phenomenon on the temperature distribution in Adhered Ceramic Tiling Systems (ACTS). Cyclic thermal and hygroscopic loads are periodic events resulting from successive and sequential processes of heating by solar irradiation and sudden cooling by heavy rains. Through an experimental program carried out in a ceramic tile prototype composed of porcelain tiles settle with adhesive mortar directly on a concrete wall, monitored the surface temperatures and temperatures at the adhesive mortar-concrete interface were measured during its exposure to heating and cooling cycles according to NBR 15575-4 (ABNT, 2021) procedures. The confinement of thermal energy (heat) inside the structure, after the beginning of cooling, demonstrates that part of the thermal stresses is maintained internally to the structure even after the drop-in surface temperature of the ceramic tile (non-homogeneous distribution), indicating that the movements structural elements of thermal origin will tend to different directions (non-uniform) and, consequently, will cause opposite stresses between layers. This results in a possible increase and concentration of stresses in certain regions that, if critical, will lead to the appearance of damage in the ceramic coating. ACTS. ACTS . (ACTS) rains wall mortarconcrete 155754 15575 4 15575- ABNT, ABNT (ABNT 2021 procedures heat (heat dropin drop nonhomogeneous non homogeneous distribution, , distribution) nonuniform uniform (non-uniform consequently layers critical coating (ACTS 1557 202 155 20 15 2 1

Resumo O estudo investigou os efeitos causados pelo fenômeno do choque térmico sobre a distribuição de temperatura em sistemas de revestimento cerâmico aderido (SRCA). Carregamentos cíclicos térmicos e higroscópicos são eventos periódicos resultado de processos sucessivos e sequenciais de aquecimento por irradiação solar e resfriamentos bruscos por chuvas. Por meio de um programa experimental realizado em um protótipo de revestimento cerâmico composto de placas de porcelanato assentadas com argamassa colante diretamente sobre uma parede de concreto, monitoraram-se as temperaturas superficiais e na interface argamassa colante-concreto durante sua exposição a ciclos de aquecimento e resfriamento, conforme procedimentos da NBR 15575-4 (ABNT, 2021). O confinamento de energia térmica (calor) no interior da estrutura, após o início do resfriamento, demonstra que parte dos esforços térmicos é mantida internamente à estrutura mesmo após a queda de temperatura superficial da placa cerâmica (distribuição não homogênea), indicando que as movimentações estruturais de origem térmica tenderão a ir em direções diferentes (não uniformes) e, consequentemente, ocasionarão solicitações opostas entre camadas. Isso resulta em possível acréscimo e concentração de tensões em determinadas regiões, que, se críticas, levarão ao surgimento do dano no revestimento cerâmico. SRCA. SRCA . (SRCA) chuvas concreto monitoraramse monitoraram colanteconcreto resfriamento 155754 15575 4 15575- ABNT, ABNT (ABNT 2021. 2021 2021) calor (calor homogênea, homogênea , homogênea) uniformes consequentemente camadas regiões críticas (SRCA 1557 202 155 20 15 2 1

Abstrac Social Housing (SH) is investigated worldwide, especially in emerging economies. However, SH literature demonstrates that there are still barriers to achieving the real benefits of those programmes. Brazilian SH programmes have positively reduced housing deficits and the vulnerability of low-income populations. However, studies developed in Brazil also reveal the negative impacts of SH. Investigating the reason for the recurrence of negative impacts is fundamental to gaining a stronger understanding of the causes and scope of SH problems. Moreover, state-of-the-art studies may support the development of actions to mitigate those problems. Thus, this study aims to categorise the major topics studied on SHs, identify and evaluate SH main failures and impacts, analyse intersections of topics, and understand their scope. A systematic review and literature mapping were applied to analyse SH studies. Although evidence emphasises significant advances in SH production, results demonstrate the intersecting panorama of occurrences that cause negative impacts and stress the need for investments and the implementation of housing public policies aligned with societal interests to improve SH. (SH worldwide economies However lowincome low income populations problems Moreover stateoftheart state art Thus SHs production

Resumo A Habitação de Interesse Social (HIS) é amplamente investigada mundialmente, especialmente nas economias emergentes. No entanto, a literatura sobre HIS demonstra que ainda existem barreiras para alcançar benefícios reais desses programas. Os programas de HISs brasileiros reduziram positivamente o déficit habitacional e a vulnerabilidade social da população de baixa renda. No entanto, estudos desenvolvidos no Brasil também revelam os impactos negativos da HISs. Investigar a razão da recorrência de impactos negativos é fundamental para maior entendimento da causa e abrangência dos problemas. Além disso, estudos do estado da arte podem auxiliar com o desenvolvimento de ações para mitigar impactos de HISs. Assim, a pesquisa visa categorizar os principais tópicos estudados sobre HIS, identificar e avaliar as deficiências dos HISs, analisar interseções de tópicos, e compreender a sua abrangência. Uma revisão sistemática e mapeamento sistemático da literatura foram aplicados para analisar e mapear os estudos de HIS. Embora as evidências enfatizem avanços significativos na produção de HISs, resultados demonstram o panorama interseccional de ocorrências que causam impactos negativos, ressaltam a necessidade de investimentos e a implementação de políticas públicas de habitação alinhadas aos interesses da sociedade para melhorar HISs. (HIS mundialmente emergentes entanto renda problemas disso Assim