Resumen Durante la valoración preanestésica de la paciente obstétrica, es fundamental evaluar la condición cardiovascular basal de la paciente, identificar riesgos potenciales y facilitar modificaciones conductuales para desarrollar una estrategia de manejo individualizada, dirigida a minimizar las complicaciones. La ecografía cardíaca a la cabecera del paciente (POCUS) es un instrumento valioso para evaluar la morfología y la función del corazón antes de un procedimiento quirúrgico. El POCUS cardiaco no está diseñado para sustituir a la ecocardiografía transtorácica formal, que corresponde al área de anestesiología cardiovascular y a la cardiología. Sin embargo, cuando se usa en conjunto con la anamnesis, el examen físico, el electrocardiograma y los resultados de exámenes de laboratorio previos, el POCUS cardiaco es un complemento valioso dentro del arsenal diagnóstico de los anestesiólogos. Permite la visualización directa del corazón y de los grandes vasos, con beneficios adicionales de velocidad, disponibilidad y bajo riesgo para la paciente. El objetivo del presente manuscrito es explorar y describir las ventajas del POCUS cardiaco durante el periodo preanestésico en pacientes obstétricas y su valor potencial para los anestesiólogos, a través de la identificación de condiciones eventualmente peligrosas que pudieran requerir un manejo preoperatorio individualizado.

Abstract During the preanesthetic assessment of the obstetric patient, it is critical to assess the patient's cardiovascular baseline condition, identify any potential risks, and facilitate behavioral modification to develop an individualized management strategy aimed at minimizing complications. Cardiac point-of-care ultrasound (POCUS) is a valuable instrument for assessing the morphology and function of the heart prior to surgery. Cardiac POCUS is not designed to replace comprehensive transthoracic echocardiography, which is the realm of cardiovascular anesthesiology and cardiology. However, when used in conjunction with anamnesis, physical examination, electrocardiogram, and previous laboratory results, cardiac POCUS is a valuable adjunct in the diagnostic toolbox of anesthesiologists. It allows for direct visualization of the heart and great vessels, with added benefits of speed, availability, and low risk for the patient. The purpose of this manuscript is to explore and describe the advantages of cardiac POCUS in the preanesthetic period of obstetric patients and its potential value for anesthesiologists through the identification of potentially hazardous conditions that may require individualized preoperative management.

RESUMEN Introducción: En actividades físicas prolongadas, la reposición de agua y el glucógeno muscular son factores limitantes en los corredores de maratón. La carga de carbohidratos (CHO) en los días previos a la competencia de resistencia es un método empleado para optimizar las reservas de glucógeno muscular y el rendimiento del ejercicio. Cómo cada gramo de glucógeno muscular se une a ≈ 2,7 a 4 gramos de agua, puede producirse retención de agua durante las dietas ricas en carbohidratos. Objetivo: Evaluar las diferencias entre las estrategias de carga de carbohidratos (Bergström y Sherman) en el contenido de agua intracelular (AIC) o extracelular (AEC). Métodos: Veintitrés corredores fueron asignados aleatoriamente a dos intervenciones (Bergström y Sherman) en un diseño cruzado. Los participantes se sometieron a una evaluación inicial antes de los 3 días de agotamiento del glucógeno, seguido de 3 días de carga de carbohidratos con un tiempo de “washout” de 30 días que consistía en una dieta y entrenamiento normales. Se utilizó bioimpedancia multifrecuencia (BIS) para evaluar AIC y AEC al inicio, después del agotamiento y después de CHO para determinar cualquier diferencia entre las dos intervenciones. También se obtuvieron muestras de sangre para evaluar el potasio. Se determinaron asociaciones entre AIC, AEC y glucógeno muscular. Resultados: No hubo diferencias en el contenido de AIC o AEC entre las dos intervenciones en ningún momento. Hubo un efecto de tiempo para AIC, con un aumento desde Post-agotamiento hasta Post-CHO sin ninguna diferencia entre las intervenciones. El potasio plasmático disminuyó entre el inicio y el post-agotamiento en ambas condiciones. No hubo diferencia en el contenido de glucógeno muscular entre las intervenciones o momentos. Conclusión: No hubo diferencias en el contenido de AIC y AEC entre las dos intervenciones en ningún momento. Nivel de Evidencia I; Pruebas de Criterios Diagnóstico Desarrollados Previamente. Introducción prolongadas maratón (CHO ejercicio 27 2 7 2, Objetivo Bergström Sherman (AIC AEC. . (AEC) Métodos cruzado washout “washout normales BIS (BIS Resultados momento Postagotamiento Post PostCHO postagotamiento post condiciones momentos Conclusión I Previamente (AEC

ABSTRACT Introduction: In prolonged physical activities, water replacement and muscle glycogen content are limiting factors in marathon runners. Carbohydrate-loading (CHO) in the days prior to endurance competition is a commonly employed method to optimise muscle glycogen stores and optimise exercise performance. Since each gram of muscle glycogen binds ∼2.7-4 grams of water, water retention may occur during carbohydrate-loading diets. Objective: To evaluate differences between CHO loading strategies (Bergström and Sherman) on intracellular (ICW) and extracellular (ECW) water content. Methods: Twenty-three runners were randomly allocated to two interventions (Bergström and Sherman) in a crossover design. Participants underwent a baseline evaluation before 3 days of glycogen depletion followed by 3 days of carbohydrate loading with a washout of 30 days consisting of normal diet and training. Multifrequency bioimpedance (BIS) was used to assess ICW and ECW at Baseline, Post-depletion and Post-CHO to determine any differences between Bergström and Sherman protocols. Blood samples were also obtained to assess potassium levels. Associations between ICW and ECW and muscle glycogen were determined. Results: There were no differences in ICW or ECW content between the two interventions at any moment. There was an effect of time for ICW, with an increase from Post-depletion to Post-CHO without any difference between interventions. Plasma potassium decreased from Baseline to Post-depletion in both conditions. There was no difference in muscle glycogen content between interventions or moments. Conclusion: There were no differences in ICW and ECW content between the Bergström and Sherman interventions at any moment. Level of Evidence I; Tests of Previously Developed Diagnostic Criteria. Introduction activities Carbohydrateloading Carbohydrate (CHO performance ∼2.74 274 ∼2.7 4 2 7 ∼2.7- carbohydrateloading diets Objective (ICW (ECW Methods Twentythree Twenty three design training BIS (BIS Postdepletion Post PostCHO protocols levels determined Results moment conditions moments Conclusion I Criteria 74 27 ∼2. ∼2 ∼

RESUMO Introdução: Em atividades físicas prolongadas a reposição hídrica e o conteúdo de glicogênio muscular são fatores limitantes em corredores de maratonas. O carregamento de carboidrato (CHO) nos dias anteriores à competição de resistência é um método comumente empregado para otimizar os estoques de glicogênio muscular e o desempenho no exercício. Uma vez que cada grama de glicogênio muscular liga-se a ≈2,7 a 4 gramas de água, a retenção hídrica pode ocorrer durante dietas de carregamento de carboidrato. Objetivo: Avaliar diferenças entre as estratégias de carregamento de carboidratos (Bergström e Sherman) no teor de água intracelular (AIC) ou água extracelular (AEC). Métodos: Vinte e três corredores foram alocados aleatoriamente para duas intervenções (Bergström e Sherman) num delineamento em “crossover”. Os participantes foram submetidos a uma avaliação inicial antes dos 3 dias de depleção de glicogênio, seguidos por 3 dias de carga de carboidratos com tempo de “washout” de 30 dias consistindo em dieta e treinamento normais. Utilizou-se a bioimpedância multifrequencial (BIS) para avaliar AIC e AEC na Etapa Inicial, Pós-depleção e Pós-CHO para determinar quaisquer diferenças entre os protocolos de Bersgstrom e Sherman. Também foram obtidas coletas de sangue para avaliar o potássio. Foram determinadas associações entre AIC, AEC e glicogênio muscular. Resultados: Não houve diferenças no conteúdo de AIC ou AEC entre as duas intervenções em qualquer momento. Houve um efeito do tempo para AIC, com aumento da etapa Pós-depleção para Pós-CHO sem qualquer diferença entre as intervenções. O potássio plasmático diminuiu entre a Linha de base e Pós-depleção em ambas condições. Não houve diferença no conteúdo de glicogênio muscular entre intervenções ou momentos. Conclusão: Não houve diferenças no conteúdo de AIC e AEC entre as intervenções de Bergström e Sherman em qualquer momento. Nível de Evidência I; Testes de Critérios Diagnósticos Desenvolvidos Anteriormente. Introdução maratonas CHO (CHO exercício ligase liga se 27 2 7 ≈2, Objetivo (AIC AEC. . (AEC) Métodos crossover. crossover “crossover” washout “washout normais Utilizouse Utilizou BIS (BIS Inicial Pósdepleção Pós PósCHO Resultados momento condições momentos Conclusão I Anteriormente ≈2 (AEC “crossover ≈

ABSTRACT Purpose: To describe cellular alterations detected by impression cytology of the ocular surface in patients with xeroderma pigmentosum. The secondary objective was to assess the reliability of impression cytology in diagnosing ocular surface squamous neoplasia. Methods: Patients with xeroderma pigmentosum underwent a single-day complete ophthalmological examination and impression cytology for ocular surface evaluation using 13 mm diameter mixed cellulose esters membrane filters and combined staining with Periodic Acid Schiff, Hematoxylin and Eosin, and Papanicolaou stains followed by microscopic analysis. The cytological findings were correlated with the clinical diagnosis. The impression cytology findings at baseline and one-year follow-up were correlated with the clinical course (no tumor, treated tumor, residual tumor recurrent tumor, new tumor). Results: Of the 42 patients examined, impression cytology was performed in 62 eyes of 34 participants (65% females). The mean age of patients was 29.6 ± 17 years (range 7-62). Fifteen eyes had a clinical diagnosis of ocular surface squamous neoplasia. Impression cytology showed goblet cells (47, 75%), inflammatory cells (12, 19%), keratinization (5, 8%), and squamous metaplasia (30, 48%). Impression cytology was positive for atypical cells in 18 patients (12 with and 6 without ocular surface squamous neoplasia). The sensitivity, specificity, positive predictive value, and negative predictive value of impression cytology (at baseline) for diagnosis of ocular surface squamous neoplasia were 80%, 87%, 67%, and 93%, respectively, using clinical diagnosis of ocular surface squamous neoplasia as the reference standard. Conclusion: Impression cytology has a moderate positive predictive value for the diagnosis of ocular surface squamous neoplasia in patients with xeroderma pigmentosum. However, the lack of detection of atypical cells on impression cytology has a high negative predictive value for ocular surface squamous neoplasia. Integration of impression cytology in the long-term management of high-risk patients, such as patients with xeroderma pigmentosum, can avoid unnecessary diagnostic biopsies. Purpose Methods singleday single day 1 Schiff Eosin analysis oneyear one year followup follow up no tumor. . tumor) Results 4 examined 3 65% 65 (65 females. females females) 296 29 29. range 762. 762 7 7-62) 47, 47 (47 75%, 75 75% , 75%) 12, 12 19%, 19 19% 19%) 5, 5 (5 8%, 8 8% 8%) 30, 30 (30 48%. 48 48% 48%) (1 neoplasia) sensitivity specificity 80 80% 87 87% 67 67% 93 93% respectively standard Conclusion However longterm long term highrisk risk biopsies (6 2 76 7-62 (4 ( (3 9 7-6 7-

ABSTRACT Purpose: To report the clinical findings, treatments, and outcomes in a series of patients with vitreous metastasis from cutaneous melanoma. Methods: This single-center, retrospective, interventional case series included patients with biopsy-confirmed vitreous metastasis from cutaneous melanoma diagnosed between 1997 and 2020. Standard 23- or 25-gauge pars plana vitrectomy was performed for diagnostic sampling. Sclerotomies were treated with double or triple freeze-thaw cryotherapy. Perioperative intravitreal injections of melphalan (32 µg/0.075 mL) were administered, when indicated. Visual acuity, intraocular pressure, and systemic and ocular treatment responses were reported. Results: Five eyes of five patients with unilateral vitreous metastasis from cutaneous melanoma were identified. The median age at diagnosis was 84 (range, 37-88) years. The median follow-up after ophthalmic diagnosis was 28 (8.5-36) months; one patient did not have a follow-up. The initial visual acuity ranged from 20/30 to hand motions. Baseline clinical findings included pigmented or non-pigmented cellular infiltration of the vitreous (5/5), anterior segment (4/5), and retina (3/5). Four patients had secondary glaucoma. Systemic therapy included checkpoint inhibitor immunotherapy (n=3, all with partial/complete response), systemic chemotherapy (n=2), surgical resection (n=3), and radiation (n=2). The median time from primary diagnosis to vitreous metastasis was 2 (2-15) years. One patient had an active systemic disease at the time of vitreous metastasis. The final visual acuity ranged from 20/40 to no light perception. Ophthalmic treatment included vitrectomy in all five patients, intravitreal administration of melphalan in three, and intravitreal administration of methotrexate in one. One patient required enucleation, and histopathology revealed extensive invasion by melanoma cells. Conclusions: Vitreous metastasis from cutaneous melanoma can present as a diffuse infiltration of pigmented or non-pigmented cells into the vitreous and may be misdiagnosed as uveitis. Diagnostic pars plana vitrectomy and periodic intravitreal chemotherapy may be indicated. Purpose treatments Methods singlecenter, singlecenter single center, center single-center retrospective biopsyconfirmed biopsy confirmed 199 2020 23 25gauge gauge 25 sampling freezethaw freeze thaw cryotherapy 32 (3 µg0075 µg 0 075 µg/0.07 mL administered indicated pressure reported Results identified 8 range, range (range 3788 37 88 37-88 years followup follow up 8.536 8536 8.5 36 5 (8.5-36 months followup. up. 2030 20 30 20/3 motions nonpigmented non 5/5, 55 5/5 , (5/5) 4/5, 45 4/5 4 (4/5) 3/5. 35 3/5 . 3 (3/5) glaucoma n=3, n3 n (n=3 partialcomplete partial complete response, response response) n=2, n2 n=2 (n=2) n=3 (n=3) n=2. 215 15 (2-15 2040 40 20/4 perception three enucleation Conclusions uveitis 19 202 ( µg007 07 µg/0.0 378 37-8 536 8.53 853 85 8. (8.5-3 203 20/ 5/ (5/5 4/ (4/5 3/ (3/5 (n= n= (n=2 21 1 (2-1 204 µg00 µg/0. 37- 53 (8.5- (5/ (4/ (3/ (n (2- µg0 µg/0 (8.5 (5 (4 (2 µg/ (8. (8

RESUMO Objetivo: Descrever os achados clínicos, tratamentos, e desfechos em uma série de pacientes com me tástases vítreas de melanoma cutâneo. Métodos: Série retrospectiva de casos de único centro com intervenção. Pacientes incluídos tiveram seu diagnóstico de MVMC confirmado por biópsia entre 1997 e 2020. Vitrectomia via pars plana com 23 ou 25 gauge foram realizadas para obter espécimens. Esclerotomias foram tratadas com crioterapia em duplo ou triplo congelamento. Injeção intravítrea perioperatória de melfalano (32 ug/0,075 mL) foi administrada quando necessário. Foram relatados acuidade visual, pressão intraocular, resposta terapêutica sistêmica e ocular. Resultados: Cinco olhos de 5 pacientes com metástases vítreas de melanoma cutâneo unilateral foram identificados. Idade média de diagnóstico foi 84 anos (variando de 37-88). Seguimento médio após diagnóstico oftalmológico foi 28 (8,5-36) meses; 1 paciente não teve acompanhamento. Acuidade visual inicial variou de 20/30 a movimentos de mão. Achados clínicos iniciais incluíram infiltração de células pigmentadas e não-pigmentadas no vítreo (5/5), segmento anterior (4/5), e retina (3/5). Quatro pacientes tiveram glaucoma secundário. Tratamento sistêmico incluiu imunoterapia com inibidores da via de sinalização (3 - todos com resposta parcial/completa), quimioterapia sistêmica (2), ressecção cirúrgica (3), e irradiação (2). Intervalo médio entre diagnóstico primário e metástases vítreas foi 2 (2-15) anos. Um paciente teve doença sistêmica ativa simultânea as metástases vítreas. Acuidade visual final variou entre 20/40 e SPL. Tratamento oftalmológico incluiu vitrectomia nos 5 pacientes, melfalano intravítreo em 3 e metotrexato intravítreo em 1. Um paciente precisou de enucleação. A histopatologia revelou invasão celular extensa de melanoma. Conclusões: Metástases vítreas de melanoma cutâneo pode se manifestar como uma infiltração difusa de células pigmentadas e não-pigmentadas no vítreo e erroneamente diagnosticada como uveites. Vitrectomia diagnóstica e quimioterapia intravítrea periódica podem estar indicadas. Objetivo tratamentos Métodos intervenção 199 2020 espécimens congelamento 32 ug0075 ug 0 075 ug/0,07 mL necessário intraocular ocular Resultados identificados 8 variando 3788. 3788 37 88 . 37-88) 8,536 8536 8,5 36 (8,5-36 meses acompanhamento 2030 20 30 20/3 mão nãopigmentadas 5/5, 55 5/5 , (5/5) 4/5, 45 4/5 4 (4/5) 3/5. 35 3/5 (3/5) secundário ( parcial/completa, parcialcompleta parcial/completa parcial completa parcial/completa) 2, (2) 3, (3) 2. 215 15 (2-15 2040 40 20/4 SPL enucleação Conclusões uveites indicadas 19 202 ug007 07 ug/0,0 378 37-88 536 8,53 853 85 8, (8,5-3 203 20/ 5/ (5/5 4/ (4/5 3/ (3/5 (2 21 (2-1 204 ug00 ug/0, 37-8 53 (8,5- (5/ (4/ (3/ (2- ug0 ug/0 37- (8,5 (5 (4 ug/ (8, (8

ABSTRACT Differentiated thyroid carcinoma (DTC) accounts for most cases of thyroid cancer, and the heterogeneity of DTC requires that management decisions be taken by a multidisciplinary team involving endocrinologists, head and neck surgeons, nuclear medicine physicians, pathologists, radiologists, radiation oncologists, and medical oncologists. It is important for nonspecialists to recognize and refer patients with DTC who will benefit from a specialized approach. Recent advances in knowledge and changes in management of DTC call for the need to raise awareness on the part of these nonspecialist physicians, including general endocrinologists and medical oncologists at large. We provide an overview of diagnostic and therapeutic principles in DTC, especially those that bear direct implication on day-to-day management of these patients by generalists. Patients with DTC may be broadly categorized as having localized, locally persistent/recurrent, or metastatic disease. Current recommendations for DTC include a three-tiered system that classifies patients with localized disease into low, intermediate, or high risk of persistent or recurrent disease. Risk stratification should be performed at baseline and repeated on an ongoing basis, depending on clinical evolution. One of the overarching goals in the management of DTC is the need to personalize treatment by tailoring its modality and intensity according to ongoing prognostic stratification, evolving knowledge about the disease, and patient characteristics and preference. In metastatic disease that is refractory to radioactive iodine, thyroid tumors are being reclassified into molecular subtypes that better reflect their biological properties and for which molecular alterations can be targeted with specific agents. (DTC cancer surgeons physicians pathologists radiologists approach large daytoday day generalists persistentrecurrent persistent/recurrent threetiered three tiered low intermediate basis evolution preference iodine agents

ABSTRACT Objective: To assess children's self-reported distress during dental procedures and investigate risk factors. Material and Methods: A total of 163 children (3–10 years old) were included from a clinical trial on diagnostic strategies for evaluating restorations in primary teeth. Treatment plans were elaborated based on the clinical examination performed at the baseline of the study. Dentists performed 742 dental procedures, and an external evaluator collected children's self-reported distress through the Wong Backer Facial Scale (WBFS) and dentists' opinions about children's behavior during the treatment. Kruskal-Wallis Test was performed to compare the distress and the dentists' perception of the different dental procedures, and multilevel ordered logistic regression analysis was conducted to the evaluate association between explanatory variables and the outcomes. Results: More complex procedures caused more distress in children (p=0.017), with a 5.5 times higher risk than simple operative treatments. Similarly, dentists reported children's worse behavior (p<0.001). Older children (older than 7 years) reported less distress than younger children (OR 0.52; CI 0.30-0.87; p=0.014). Patients reported greater distress in the first consultations, reducing the chance of higher scores by 16% in the next interventions. Conclusion: Children experience higher levels of distress during their first treatment appointments. More complex operative procedures and the child's age below 7 years were risk factors associated with greater distress during dental treatment. Objective childrens s selfreported self Methods 16 3–10 310 3 10 (3–1 old teeth study 74 WBFS (WBFS KruskalWallis Kruskal Wallis outcomes Results p=0.017, p0017 p p=0.017 , 0 017 (p=0.017) 55 5 5. treatments Similarly p<0.001. p0001 p<0.001 . 001 (p<0.001) older OR 0.52 052 52 0.300.87 030087 0.30 0.87 30 87 0.30-0.87 p=0.014. p0014 p=0.014 014 p=0.014) consultations interventions Conclusion appointments childs child 1 3–1 31 (3– p001 p=0.01 01 (p=0.017 p000 p<0.00 00 (p<0.001 0.5 05 300 0.300.8 03008 030 0.3 087 0.8 8 0.30-0.8 3– (3 p00 p=0.0 (p=0.01 p<0.0 (p<0.00 0. 0.300. 0300 03 08 0.30-0. ( p0 p=0. (p=0.0 p<0. (p<0.0 0.300 0.30-0 p=0 (p=0. p<0 (p<0. 0.30- p= (p=0 p< (p<0 (p= (p< (p

RESUMO Este estudo visa padronizar o exame clínico e complementar, mediante a utilização de eletromiografia (EMG) de superfície, para avaliar a função neuromuscular da cauda equina. Primeiramente, foram realizados exames clínicos das caudas e medições EMG em 10 animais saudáveis, sem qualquer interferência ou manipulação da cauda. Esse experimento inicial teve como objetivo estabelecer um padrão de exame clínico e dos resultados de EMG. Os animais sofreram bloqueio do plexo nervoso da cauda no segundo experimento com o uso de agente anestésico. O objetivo compara o exame clínico e os achados EMG entre as caudas anestesiadas e saudáveis. Por fim, dois animais foram utilizados no terceiro experimento, em que foi realizada infiltração periférica dos plexos nervosos da cauda com agente neurolítico. O estudo obteve com sucesso um padrão para o exame clínico de uma cauda equina saudável e estabeleceu um padrão para o exame clínico de uma cauda após infiltração com agentes anestésicos e neurolíticos. Diferenças significativas foram observadas no exame clínico, bem como nos valores EMG antes e após a infiltração local com anestésico (P=0,04) e agente neurolítico (P=0,03). O estudo apresenta um protocolo de exame clínico que utiliza a eletromiografia de superfície como ferramenta diagnóstica para o bloqueio da cauda equina. complementar (EMG Primeiramente 1 saudáveis fim neurolíticos P=0,04 P004 P 0 04 (P=0,04 P=0,03. P003 P=0,03 . 03 (P=0,03) P=0,0 P00 (P=0,0 (P=0,03 P=0, P0 (P=0, P=0 (P=0 P= (P= (P

ABSTRACT This study aims to standardize the clinical and complementary examination using surface electromyography (EMG) to assess the neuromuscular function of the equine tail. Firstly, clinical examinations of the tails and EMG measurements were performed on ten healthy animals without any tail interference or manipulation. This initial experiment aimed to establish a baseline for clinical examination and EMG results. The animals underwent tail nerve plexus blockade in the second experiment using an anesthetic agent. The objective compares the clinical examination and EMG findings between the anesthetized and non-manipulated tails. Finally, two animals were used in the third experiment, where peripheral infiltration of the tail nerve plexuses was performed using a neurolytic agent. The study successfully obtained a pattern for the clinical examination of a healthy equine tail and established a pattern for the clinical examination of a tail after infiltration with anesthetic and neurolytic agents. Significant differences were observed in the clinical examination before and after the application of local anesthesia, as well as in the EMG values before and after local infiltration with anesthetic (P=0.04) and neurolytic agent (P=0.03). The presented study introduces a clinical examination protocol that utilizes surface electromyography as a diagnostic tool for cauda equina block. (EMG Firstly manipulation results nonmanipulated non manipulated Finally agents anesthesia P=0.04 P004 P 0 04 (P=0.04 P=0.03. P003 P=0.03 . 03 (P=0.03) block P=0.0 P00 (P=0.0 (P=0.03 P=0. P0 (P=0. P=0 (P=0 P= (P= (P

Abstract Synovial sarcoma is a rare malignity of mesenchymal origin; the diagnostic approach usually begins by documenting a soft tissue tumor; however, it results in a challenging diagnosis when it is more profound, of small size, or primary from the bone. The present report describes a patient who presented insidious onset hip pain attributed to rheumatoid arthritis, with a fatal outcome due to baseline disease and surgery complications. The underestimation of hip pain, mainly when there is no palpable mass, may delay the diagnosis. origin tumor however profound size bone arthritis complications mass

Resumo Sarcoma sinovial é uma rara malignidade de origem mesenquimal; a abordagem diagnóstica geralmente começa documentando um tumor de tecido mole; no entanto, resulta em um diagnóstico desafiador quando é mais profundo, de pequeno porte ou primário do osso. O presente relato descreve um paciente que apresentou dor insidiosa no quadril atribuída a artrite reumatoide, com desfecho fatal devido a doenças de base e complicações cirúrgicas. A subestimação da dor no quadril, principalmente quando não há massa palpável, pode atrasar o diagnóstico. mesenquimal mole entanto profundo osso reumatoide cirúrgicas palpável

Resumen Este estudio analiza los cambios estructurales experimentados por un equipo interprofesional que implementa un programa de intervención psicosocial dirigido a víctimas de la guerra en Colombia. Los equipos están compuestos por psicólogos, trabajadores sociales y facilitadores comunitarios que proporcionan atención a nivel individual, familiar y comunitario. Se aplicaron métodos de evaluación estructural para identificar cambios en la cohesión de las redes de reconocimiento entre profesionales, así como la preferencia para colaborar y el intercambio de información enviada y recibida. La recogida de información se produjo en dos series temporales –tiempo 1 (T1) y tiempo 2 (T2)– con un intervalo de tres meses. Se utilizó una estadística aplicada al análisis de datos relacionales para determinar los cambios en las redes en T1 y T2. En el período de referencia se incrementó la densidad en las redes de reconocimiento [. = 1.7105, (IC 95 %: -.0123 - .185), . < .0444] y de preferencia para trabajar [. = 2.0942, (IC 95 %: .005 - .1521), . < .0218]. Las redes de intercambio de información no experimentaron cambios significativos. Las regresiones múltiples a nivel diádico indican que la preferencia para trabajar e intercambiar información en T1, predicen el intercambio de información relativo tanto a peticiones de información recibidas como enviadas en T2. Se discuten los resultados para optimizar la implementación de programas de intervención psicosocial desarrolladas por equipos interprofesionales.

Abstract The study analyzes the structural changes experienced by an interprofessional team implementing a psychosocial intervention program for victims of war in Colombia. The program is called "PAPSIVI" (Programa de Atención Psicosocial y Salud Integral a Víctimas), which has been operating in Colombia since 2013, thanks to Law 1448 of 2011 to improve the quality of life and repair the damage of the victims of the armed conflict in Colombia. It only served people registered in the Single Registry of Victims (RUV), which had 9'165,126 records throughout the country until September 2021. This program follows a comprehensive and restorative approach that defines victims as protagonists of their own process of empowerment and positive change (Laplante and Holguin, 2006; Thompson, 1996). For this purpose, a multilevel intervention is carried out at the individual, family and community levels. The program is implemented by teams of professionals (psychologists, social workers and community facilitators) of varying sizes depending on the number of victims served in the municipalities. Psychologists provide individual psychological care and, to a lesser extent, family therapy is also offered to try to repair psychosocial damage from exposure to situations of violence (Oficina de Promoción Social, 2017). Social workers carry out community interventions to promote the associative fabric and social capital. Community promoters are facilitators and connect professionals with the potential beneficiaries of the intervention. The latter are very important, having themselves the status of victims, which increases the ecological validity of the intervention. Due to the characteristics of the implementation of this initiative, which takes into account the difficulties of the context (with situations of deprivation and vulnerability), as well as the particularities of the participants, it is valid to ask in this research what are the structural changes experienced by the teams of professionals who implement PAPSIVI. For this, structural evaluation methods were applied to identify changes in the cohesion of recognition networks among professionals, the preference to collaborate and the exchange of information sent and received. Data collection took place in two time series (T1 before - T2 after) with an interval of three months. Statistics applied to relational data analysis were used to determine changes in the networks at time T2. In the results it was found that in the baseline period the density in the recognition [t = 1.7105, (95 % CI: -.0123 - .185), p < .0444] and work preference [t = 2.0942, (95 % CI: .005 - .1521), p < .0218] networks increased. Information exchange networks did not experience significant changes. Multiple regressions at the dyadic level indicate that the preference for working and exchanging information at T1 predicts information exchange relative to both information requests received and sent at T2. It is concluded that the results shed light for: (a) optimize the design of psychosocial intervention teams; (b) improve their functioning by introducing horizontal organizational communication tools (among the members of each team), transversal (among the members of the teams implementing the program in different municipalities), and vertical (by promoting communication between professionals and program managers/responsible persons), and (c) achieve that changes in the structure of the teams serve as a diagnostic tool for functional problems of the team associated with the exchange of professional information and the referral of users. Ultimately, better integration of the teams leads to better psychosocial profiles of the users of programs such as PAPSIVI and allows them to better adapt their activities to the needs of the users, which improves the effectiveness of the intervention (Virto, 2021).

BACKGROUND: Substantial additional efforts are needed to prevent, find and successfully treat tuberculosis (TB) in South Africa (SA). In the past decade, an increasing body of mathematical modelling research has investigated the population-level impact of TB prevention and care interventions. To date, this evidence has not been assessed in the SA context OBJECTIVE: To systematically review mathematical modelling studies that estimated the impact of interventions towards the World Health Organization's End TB Strategy targets for TB incidence, TB deaths and catastrophic costs due to TB in SA METHODS: We searched the PubMed, Web of Science and Scopus databases for studies that used transmission-dynamic models of TB in SA and reported on at least one of the End TB Strategy targets at population level. We described study populations, type of interventions and their target groups, and estimates of impact and other key findings. For studies of country-level interventions, we estimated average annual percentage declines (AAPDs) in TB incidence and mortality attributable to the intervention RESULTS: We identified 29 studies that met our inclusion criteria, of which 7 modelled TB preventive interventions (vaccination, antiretroviral treatment (ART) for HIV, TB preventive treatment (TPT)), 12 considered interventions along the care cascade for TB (screening/case finding, reducing initial loss to follow-up, diagnostic and treatment interventions), and 10 modelled combinations of preventive and care-cascade interventions. Only one study focused on reducing catastrophic costs due to TB. The highest impact of a single intervention was estimated in studies of TB vaccination, TPT among people living with HIV, and scale-up of ART. For preventive interventions, AAPDs for TB incidence varied between 0.06% and 7.07%, and for care-cascade interventions between 0.05% and 3.27% CONCLUSION: We describe a body of mathematical modelling research with a focus on TB prevention and care in SA. We found higher estimates of impact reported in studies of preventive interventions, highlighting the need to invest in TB prevention in SA. However, study heterogeneity and inconsistent baseline scenarios limit the ability to compare impact estimates between studies. Combinations, rather than single interventions, are likely needed to reach the End TB Strategy targets in SA

RESUMO Objetivo: Descrever os achados clínicos, tratamentos, e desfechos em uma série de pacientes com me tástases vítreas de melanoma cutâneo. Métodos: Série retrospectiva de casos de único centro com intervenção. Pacientes incluídos tiveram seu diagnóstico de MVMC confirmado por biópsia entre 1997 e 2020. Vitrectomia via pars plana com 23 ou 25 gauge foram realizadas para obter espécimens. Esclerotomias foram tratadas com crioterapia em duplo ou triplo congelamento. Injeção intravítrea perioperatória de melfalano (32 ug/0,075 mL) foi administrada quando necessário. Foram relatados acuidade visual, pressão intraocular, resposta terapêutica sistêmica e ocular. Resultados: Cinco olhos de 5 pacientes com metástases vítreas de melanoma cutâneo unilateral foram identificados. Idade média de diagnóstico foi 84 anos (variando de 37-88). Seguimento médio após diagnóstico oftalmológico foi 28 (8,5-36) meses; 1 paciente não teve acompanhamento. Acuidade visual inicial variou de 20/30 a movimentos de mão. Achados clínicos iniciais incluíram infiltração de células pigmentadas e não-pigmentadas no vítreo (5/5), segmento anterior (4/5), e retina (3/5). Quatro pacientes tiveram glaucoma secundário. Tratamento sistêmico incluiu imunoterapia com inibidores da via de sinalização (3 - todos com resposta parcial/completa), quimioterapia sistêmica (2), ressecção cirúrgica (3), e irradiação (2). Intervalo médio entre diagnóstico primário e metástases vítreas foi 2 (2-15) anos. Um paciente teve doença sistêmica ativa simultânea as metástases vítreas. Acuidade visual final variou entre 20/40 e SPL. Tratamento oftalmológico incluiu vitrectomia nos 5 pacientes, melfalano intravítreo em 3 e metotrexato intravítreo em 1. Um paciente precisou de enucleação. A histopatologia revelou invasão celular extensa de melanoma. Conclusões: Metástases vítreas de melanoma cutâneo pode se manifestar como uma infiltração difusa de células pigmentadas e não-pigmentadas no vítreo e erroneamente diagnosticada como uveites. Vitrectomia diagnóstica e quimioterapia intravítrea periódica podem estar indicadas.

ABSTRACT Purpose: To report the clinical findings, treatments, and outcomes in a series of patients with vitreous metastasis from cutaneous melanoma. Methods: This single-center, retrospective, interventional case series included patients with biopsy-confirmed vitreous metastasis from cutaneous melanoma diagnosed between 1997 and 2020. Standard 23- or 25-gauge pars plana vitrectomy was performed for diagnostic sampling. Sclerotomies were treated with double or triple freeze-thaw cryotherapy. Perioperative intravitreal injections of melphalan (32 µg/0.075 mL) were administered, when indicated. Visual acuity, intraocular pressure, and systemic and ocular treatment responses were reported. Results: Five eyes of five patients with unilateral vitreous metastasis from cutaneous melanoma were identified. The median age at diagnosis was 84 (range, 37-88) years. The median follow-up after ophthalmic diagnosis was 28 (8.5-36) months; one patient did not have a follow-up. The initial visual acuity ranged from 20/30 to hand motions. Baseline clinical findings included pigmented or non-pigmented cellular infiltration of the vitreous (5/5), anterior segment (4/5), and retina (3/5). Four patients had secondary glaucoma. Systemic therapy included checkpoint inhibitor immunotherapy (n=3, all with partial/complete response), systemic chemotherapy (n=2), surgical resection (n=3), and radiation (n=2). The median time from primary diagnosis to vitreous metastasis was 2 (2-15) years. One patient had an active systemic disease at the time of vitreous metastasis. The final visual acuity ranged from 20/40 to no light perception. Ophthalmic treatment included vitrectomy in all five patients, intravitreal administration of melphalan in three, and intravitreal administration of methotrexate in one. One patient required enucleation, and histopathology revealed extensive invasion by melanoma cells. Conclusions: Vitreous metastasis from cutaneous melanoma can present as a diffuse infiltration of pigmented or non-pigmented cells into the vitreous and may be misdiagnosed as uveitis. Diagnostic pars plana vitrectomy and periodic intravitreal chemotherapy may be indicated.

Abstract This study aimed to make a longitudinal analysis of interexaminer calibration reproducibility in diagnosing dental caries in posterior teeth, by examiners without previous experience in epidemiological studies. A group of 11 inexperienced examiners underwent theoretical-practical training and calibration assessments, assisted by a standard examiner. An examiner who did not participate directly in the research selected 5-year-old children with and without caries. The D3 diagnostic threshold was used to evaluate dental caries, based on the World Health Organization (WHO) criteria. The initial calibration (baseline) was performed after the theoretical-practical training session, and consisted of examining 20 children; the second calibration occurred three months later, and involved evaluating another 18 children. The interexaminer agreement was obtained by kappa statistics, and by overall percentage agreement. The paired t-test was applied to compare the values for kappa means and overall percentage agreement between the time points studied. At baseline, the values for kappa (> 0.81) and overall percentage agreement (> 95.63%) were considered high. At the 3-month calibration assessment, all the examiners showed some decrease in both kappa (p < 0.0001) and overall percentage agreement (p = 0.0102). The calibration process currently proposed by the WHO is effective. However, reproducibility was not maintained over time for inexperienced examiners evaluating the posterior teeth of 5-year-old children, under epidemiological conditions. studies 1 theoreticalpractical theoretical practical assessments 5yearold yearold 5 year old D (WHO criteria baseline (baseline session 2 later statistics ttest t test studied > ( 0.81 081 0 81 95.63% 9563 95 63 high 3month month 3 assessment p 0.0001 00001 0001 0.0102. 00102 0.0102 . 0102 0.0102) effective However conditions 0.8 08 8 95.63 956 9 6 0.000 0000 000 0010 0.010 010 0. 95.6 0.00 00 001 0.01 01 95. 0.0

Abstract Background Cardiopulmonary Exercise Testing (CPX) is essential for the assessment of exercise capacity for patients with Chronic Heart Failure (CHF). Respiratory gas and hemodynamic parameters such as Ventilatory Efficiency (VE/VCO2 slope), peak oxygen uptake (peak VO2), and heart rate recovery are established diagnostic and prognostic markers for clinical populations. Previous studies have suggested the clinical value of metrics related to respiratory gas collected during recovery from peak exercise, particularly recovery time to 50% (T1/2) of peak VO2. The current study explores these metrics in detail during recovery from peak exercise in CHF. Methods Patients with CHF who were referred for CPX and healthy individuals without formal diagnoses were assessed for inclusion. All subjects performed CPX on cycle ergometers to volitional exhaustion and were monitored for at least five minutes of recovery. CPX data were analyzed for overshoot of respiratory exchange ratio (RER=VCO2/VO2), ventilatory equivalent for oxygen (VE/VO2), end-tidal partial pressure of oxygen (PETO2), and T1/2 of peak VO2 and VCO2. Results Thirty-two patients with CHF and 30 controls were included. Peak VO2 differed significantly between patients and controls (13.5 ± 3.8 vs. 32.5 ± 9.8 mL/Kg*min−1, p < 0.001). Mean Left Ventricular Ejection Fraction (LVEF) was 35.9 ± 9.8% for patients with CHF compared to 61.1 ± 8.2% in the control group. The T1/2 of VO2, VCO2 and VE was significantly higher in patients (111.3 ± 51.0, 132.0 ± 38.8 and 155.6 ± 45.5s) than in controls (58.08 ± 13.2, 74.3 ± 21.1, 96.7 ± 36.8s; p < 0.001) while the overshoot of PETO2, VE/VO2 and RER was significantly lower in patients (7.2 ± 3.3, 41.9 ± 29.1 and 25.0 ± 13.6%) than in controls (10.1 ± 4.6, 62.1 ± 17.7 and 38.7 ± 15.1%; all p < 0.01). Most of the recovery metrics were significantly correlated with peak VO2 in CHF patients, but not with LVEF. Conclusions Patients with CHF have a significantly blunted recovery from peak exercise. This is reflected in delays of VO2, VCO2, VE, PETO2, RER and VE/VO2, reflecting a greater energy required to return to baseline. Abnormal respiratory gas kinetics in CHF was negatively correlated with peak VO2 but not baseline LVEF. (CPX . (CHF) VE/VCO2 VEVCO2 VEVCO VCO (VE/VCO slope, slope , slope) VO VO2) populations 50 T12 T T1 2 (T1/2 inclusion RER=VCO2/VO2, RERVCO2VO2 RERVCOVO RER=VCO2/VO2 (RER=VCO2/VO2) VEVO2 VEVO (VE/VO2) endtidal end tidal PETO2 PETO (PETO2) T1/ Thirtytwo Thirty two 3 included 13.5 135 13 5 (13. 38 8 3. vs 325 32 32. 98 9 9. mLKgmin1 mLKgmin mL Kg min 1 mL/Kg*min−1 0.001. 0001 0.001 0 001 LVEF (LVEF 359 35 35. 611 61 61. 82 8.2 group 111.3 1113 111 (111. 510 51 51.0 1320 132 132. 388 38. 1556 155 6 155. 45.5s 455s s 45 5s 58.08 5808 58 08 (58.0 13.2 743 74 74. 211 21 21.1 967 96 7 96. 36.8s 368s 36 8s VE/VO 7.2 72 (7. 33 3.3 419 41 41. 291 29 29. 250 25 25. 13.6% 136 10.1 101 10 (10. 46 4 4.6 621 62 62. 177 17 17. 387 15.1% 151 15 0.01. 0.01 01 0.01) (CHF VE/VCO (T1/ RERVCO RERVCO2VO RER=VCO2/VO (RER=VCO2/VO2 (VE/VO2 (PETO2 13. (13 mL/Kg*min− 000 0.00 00 8. 111. 11 (111 51. 58.0 580 (58. 21. 7. (7 13.6 10. (10 4. 15.1 0.0 (T1 (RER=VCO2/VO (VE/VO (PETO (1 mL/Kg*min (11 58. (58 ( 15. 0. (T (5

ABSTRACT OBJECTIVE To build an integrated database of individual and service data from the cohort of people who started antiretroviral therapy (ART), from 2015 to 2018, in Brazil. METHODS Open cohort study that includes people aged 15 years or older who started ART from 2015 to 2018, with follow-up in services of the Brazilian Unified Health System (SUS), and who responded to the 2016/2017 Qualiaids national survey. The source of individual data was the related HIV database, derived from the probabilistic linkage between data from the SUS systems of diagnostic information, medication, tests, and deaths. The data source for the services was the services’ response database to the Qualiaids survey. After analysis of consistency and exclusions, the database of individuals was deterministically related to the database of services. RESULTS The cohort comprised 132,540 people monitored in 941 SUS services. Of these services, 59% are located in the Southeast region and 49% followed 51 to 500 cohort participants. The average performance of organization and management of patient care ranged from 29% to 75%. Most of the cohort participants are male, black and mixed, aged between 20 and 39 years old, and have between 4 and 11 years of schooling. Median baseline T-CD4 was 419 cells/mm3, 6% had an episode of tuberculosis, and 2% died of HIV disease. CONCLUSION For the first time in Brazil, this cohort provides the opportunity for a joint analysis of individual factors and services in the production of positive and negative clinical outcomes of HIV treatment. ART, , (ART) 201 2018 Brazil 1 followup follow up SUS, (SUS) 20162017 2016 2017 2016/201 survey information medication tests deaths exclusions 132540 132 540 132,54 94 59 49 5 50 29 75 75% male mixed 2 3 old schooling TCD4 TCD T CD4 CD T-CD 41 cellsmm3 cellsmm cells mm3 mm cells/mm3 6 tuberculosis disease treatment (ART (SUS 2016201 2016/20 13254 13 54 132,5 9 7 cells/mm 201620 2016/2 1325 132, 20162 2016/

RESUMO OBJETIVO Construir uma base integrada de dados individuais e dos serviços da coorte de pessoas que iniciaram terapia antirretroviral (TARV) entre 2015 e 2018 no Brasil. MÉTODOS Estudo de coorte aberta que incluiu pessoas de 15 anos ou mais que iniciaram TARV entre 2015 e 2018, com acompanhamento em serviços do Sistema Único de Saúde (SUS), e que responderam ao inquérito nacional Qualiaids de 2016/2017. A fonte de dados individuais foi o banco relacionado do HIV, proveniente do relacionamento probabilístico entre dados dos sistemas de informação de diagnóstico, medicação, exames e óbitos do SUS. A fonte de dados dos serviços foi o banco de respostas dos serviços ao inquérito Qualiaids. Após análise de consistência e exclusões, o banco dos indivíduos foi relacionado deterministicamente com o banco de serviços. RESULTADOS A coorte reuniu 132.540 pessoas acompanhadas em 941 serviços do SUS. Desses serviços, 59% localizam-se na região Sudeste e 49% acompanharam 51 a 500 participantes da coorte. O desempenho médio de organização e gerência da assistência ao paciente variou de 29% a 75%. A maioria dos participantes da coorte é do sexo masculino, preto e pardo, com idade entre 20 e 39 anos e tem entre 4 e 11 anos de escolaridade. O T-CD4 mediano basal foi de 419 células/mm3, 6% tiveram episódio de tuberculose e 2% foram a óbito por doença do HIV. CONCLUSÃO A coorte oportuniza pela primeira vez no Brasil a análise conjunta de fatores individuais e dos serviços na produção dos desfechos clínicos positivos e negativos do tratamento do HIV. (TARV 201 1 SUS, SUS , (SUS) 20162017 2016 2017 2016/2017 HIV diagnóstico medicação exclusões 132540 132 540 132.54 94 59 localizamse localizam se 49 5 50 29 75 75% masculino pardo 2 3 escolaridade TCD4 TCD T CD4 CD T-CD 41 célulasmm3 célulasmm células mm3 mm células/mm3 6 (SUS 2016201 2016/201 13254 13 54 132.5 9 7 células/mm 201620 2016/20 1325 132. 20162 2016/2 2016/

Resumen Objetivo Evaluar la efectividad del juego Enfermero Diagnosticador para la enseñanza del razonamiento diagnóstico en estudiantes de enfermería. Métodos Estudio cuasi experimental desarrollado en tres etapas: elaboración del juego de mesa Enfermero Diagnosticador, análisis de contenido de los casos clínicos por especialistas y aplicación del juego de mesa Enfermero Diagnosticador. Participaron 19 especialistas en el análisis de contenido. El pretest y el postest se realizó con 11 estudiantes de la carrera de Enfermería que cursaban la materia Bases de la Semiología. Resultados Los nueve casos clínicos que formaban parte del juego fueron organizados en pistas que podían respaldar la composición de los diagnósticos de enfermería. Estos casos fueron evaluados con buena idoneidad por 19 especialistas en razonamiento diagnóstico o tecnología educativa. Al comparar el rendimiento de los estudiantes antes y después del experimento, la inferencia diagnóstica correcta presentó diferencia estadística significativa en la resolución del primer y segundo diagnóstico (p=0,008). Además, la escritura correcta del diagnóstico fue un punto destacado en el postest, y todos los ítems evaluados presentaron una mejora en el momento posterior a la aplicación del juego de mesa. Conclusión Se concluye que el juego de mesa Enfermero Diagnosticador es efectivo para respaldar la enseñanza del razonamiento diagnóstico en enfermería. De esta forma, se pretende avanzar en el estado del diseño en lo que respecta a juegos educativos de bajo costo y fácil acceso para respaldar el razonamiento diagnóstico en enfermería. enfermería etapas 1 Semiología educativa experimento p=0,008. p0008 p p=0,008 . 0 008 (p=0,008) Además forma p000 p=0,00 00 (p=0,008 p00 p=0,0 (p=0,00 p0 p=0, (p=0,0 p=0 (p=0, p= (p=0 (p= (p

Abstract Objective To assess the “Enfermeiro Diagnosticador” board game effectiveness for teaching diagnostic reasoning among nursing students. Methods This is a quasi-experimental study, developed in three stages: “Enfermeiro Diagnosticador” (Diagnostician Nurse) game construction; content analysis of clinical cases by experts; and “Enfermeiro Diagnosticador” game application. Nineteen experts participated in content analysis. Pre- and post-tests were performed with 11 undergraduate nursing students, attending semiology, a baseline subject. Results The nine clinical cases that comprised the game were organized into clues capable of subsidizing the composition of nursing diagnoses. These were assessed with good suitability by 19 experts in diagnostic reasoning and/or educational technology. Comparing students’ performance before and after the experiment, the correct diagnostic inference showed a statistically significant difference in the resolution of the first and second diagnoses (p=0.008). Moreover, the correct writing of diagnosis was a highlight in the post-test and all the items assessed showed improvement after the board game application. Conclusion It is concluded that “Enfermeiro Diagnosticador” is effective in supporting the teaching of diagnostic reasoning in nursing. In this way, we aim to advance in the state of the art with regard to low-cost and easily accessible educational games to support diagnostic reasoning in nursing. Enfermeiro Diagnosticador students quasiexperimental quasi experimental study stages Diagnostician Nurse construction application Pre posttests post tests 1 semiology subject andor or technology experiment p=0.008. p0008 p p=0.008 . 0 008 (p=0.008) Moreover posttest test way lowcost low cost p000 p=0.00 00 (p=0.008 p00 p=0.0 (p=0.00 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p

Resumo Objetivo Avaliar a efetividade do jogo de tabuleiro Enfermeiro Diagnosticador para o ensino do raciocínio diagnóstico em estudantes de enfermagem. Métodos Estudo quase-experimental, desenvolvido em três etapas: construção do jogo de tabuleiro Enfermeiro Diagnosticador; análise de conteúdo dos casos clínicos por especialistas; e aplicação do jogo de tabuleiro Enfermeiro Diagnosticador. Participaram 19 especialistas na análise de conteúdo. O pré-teste e o pós-teste foram realizados com 11 discentes do Curso de Graduação em Enfermagem, cursando a Disciplina de Bases da Semiologia. Resultados Os nove casos clínicos que compuseram o jogo foram organizados em pistas capazes de subsidiar a composição dos diagnósticos de enfermagem. Esses foram avaliados com boa adequação por 19 especialistas em raciocínio diagnóstico e/ou tecnologia educacional. Comparando o desempenho dos discentes antes e após o experimento, a inferência diagnóstica correta apresentou diferença estatística significativa na resolução do primeiro e segundo diagnósticos (p=0,008). Além disso, a escrita correta do diagnóstico foi ponto de destaque no pós-teste e todos os itens avaliados apresentaram melhora no momento pós-aplicação do jogo de tabuleiro. Conclusão Conclui-se que o jogo de tabuleiro Enfermeiro Diagnosticador é efetivo no apoio ao ensino do raciocínio diagnóstico em enfermagem. Desta forma, almeja-se avançar no estado da arte no que concerne a jogos educativos de baixo custo e fácil acesso para dar suporte ao raciocínio diagnóstico em enfermagem. enfermagem quaseexperimental, quaseexperimental quase experimental, experimental quase-experimental etapas 1 préteste pré teste pósteste pós Enfermagem Semiologia eou ou educacional experimento p=0,008. p0008 p p=0,008 . 0 008 (p=0,008) disso pósaplicação Concluise Conclui se forma almejase almeja p000 p=0,00 00 (p=0,008 p00 p=0,0 (p=0,00 p0 p=0, (p=0,0 p=0 (p=0, p= (p=0 (p= (p