Abstract (Introduction): The search for techniques and methods for managing sludge generated during wastewater treatment is necessary to ensure sustainable sanitation in the medium term in Latin America. An interesting approach involves converting sludge into a biosolid usable in agriculture through alkaline sanitization. (Objective): We evaluated this technique’s efficacy and economic and environmental viability for obtaining an agriculturally usable type A biosolid from municipal wastewater treatment plant (WWTP) sludge. (Methodology): To this end, the efficacy in reducing microbiological parameters was experimentally tested at the laboratory scale using quicklime, for anaerobic and aerobic WWTP sludge. The experimental results fed a benefit/cost analysis model and a life cycle assessment. (Results): It was confirmed that applying a 40 % lime dose allowed the obtention of a type A biosolid with non-detectable concentrations of pathogenic microorganisms, which remained in that condition for more than 30 days. Additionally, the benefit/cost and life cycle analyses concluded that this option would be more attractive than sludge disposal in a landfill, due to the corresponding savings in chemical compounds (fertilizers, agricultural lime). (Conclusions): Therefore, alkaline sanitization can be considered suitable for WWTP sludge management. Its application on a larger scale should be further investigated in the country and the Latin-American region, considering the risk associated to the presence of heavy metals too.

Resumen (Introducción): La búsqueda de técnicas y modelos de gestión del lodo generado durante el tratamiento de las aguas residuales es necesaria para garantizar un saneamiento sostenible a mediano plazo en América Latina. Una vía interesante consiste en convertir el lodo en un biosólido aprovechable en la agricultura por medio de la higienización alcalina. (Objetivo): Se evaluó la eficacia y la viabilidad económica y ambiental de esta técnica para la obtención de un biosólido tipo A aprovechable en la agricultura a partir de lodo de planta de tratamiento de aguas residuales (PTAR) ordinaria. (Metodología): Para ello se probó experimentalmente en escala de laboratorio la eficacia en el decaimiento de parámetros microbiológicos higienizados con cal viva, usando lodo anaeróbico y aeróbico de PTAR. Los resultados experimentales alimentaron un modelo de análisis de beneficio/costo y de ciclo de vida. (Resultados): Pudo corroborarse que la aplicación de dosis de cal de 40 % permitió obtener un biosólido tipo A con concentraciones de microorganismos patógenos no detectables, lo cual se mantuvo en esa condición por más de 30 días. Además, el análisis de beneficio/costo y de ciclo de vida permitieron concluir que esta opción sería más atractiva que la disposición del lodo en un relleno sanitario, debido al ahorro correspondiente en compuestos químicos (fertilizantes o cal agrícola) derivado de su aprovechamiento. (Conclusiones): Por lo tanto, la técnica de higienización alcalina puede considerarse como adecuada para la gestión del lodo de PTAR y su aplicación a mayor escala debe investigarse en mayor detalle en el país y la región latinoamericana, considerando también el riesgo de presencia de metales pesados en este subproducto.

Résumé Par la méthode historique-comparative, cet article aborde les impacts, sur les États-Unis, l’Allemagne et le Brésil, des quatre crises économiques internationales survenues jusqu’en 2019, en se concentrant principalement sur leurs effets sur le régime politique et le post-2008. Les pays sélectionnés ont eu des expériences autoritaires distinctes, anciennes ou actuelles. Je conceptualise l’État de manière tridimensionnelle : régime politique, appareil décisionnel et structure de domination politique appuyée sur des coalitions. J’argumente que les conjonctures internationales critiques ont tendance à avoir un impact sur cette tridimensionalité, facilitant l’observation de ses variations et continuités. Je formule et corrobore trois hypothèses sur ces crises : elles ont tendance à augmenter ou diminuer les niveaux de démocratie ou d’autocratie des régimes ou à les changer ; la réponse autocratisante dépend d’une relation de forces pro-entreprises, subordonnant les travailleurs ; l’engagement démocratique des acteurs s’oppose à l’autocratisation. La contribution à la littérature réside dans la manière d’aborder les processus d’autocratisation et de démocratisation, ici étudiés à travers les impacts des crises économiques internationales sur les États. Les conjonctures critiques éclairent les composants clés de la mutabilité du Léviathan. On examine le régime politique par la politique économique des relations entre l’État, les marchés et les classes sociales, et non exclusivement par les variables politico-institutionnelles. On analyse les mécanismes d’intersection de la sphère et des acteurs politico-institutionnels avec les structures et acteurs économiques et sociaux, qui, impactant la tridimensionalité de l’État, entraînent des changements de régime ou dans le régime. historiquecomparative, historiquecomparative historique comparative, comparative historique-comparative ÉtatsUnis, ÉtatsUnis États Unis, Unis États-Unis lAllemagne l Allemagne Brésil jusquen jusqu 2019 post2008. post2008 post 2008. 2008 post-2008 distinctes actuelles lÉtat État coalitions Jargumente J argumente lobservation observation continuités dautocratie d autocratie dune une proentreprises, proentreprises pro entreprises, entreprises pro-entreprises lengagement engagement soppose s oppose lautocratisation. lautocratisation autocratisation. autocratisation l’autocratisation daborder aborder dautocratisation démocratisation Léviathan lÉtat, État, sociales politicoinstitutionnelles. politicoinstitutionnelles politico institutionnelles. institutionnelles politico-institutionnelles dintersection intersection politicoinstitutionnels institutionnels sociaux qui 201 post200 200 post-200 20 post20 post-20 2 post2 post-2 post-

Resumen Por medio del método histórico comparativo, se abordan los impactos en los Estados de Estados Unidos, Alemania y Brasil, de las cuatro crisis económicas internacionales que han ocurrido hasta 2019, enfocándose, principalmente, en sus efectos en el régimen político y en el periodo posterior a 2008. Los países seleccionados tuvieron distintas experiencias autoritarias, antiguas o actuales. Defino al Estado de una forma tridimensional: régimen político, aparato decisor y estructura de dominación política respaldada en coaliciones. Argumento que las respectivas coyunturas críticas internacionales tienden a impactar esta tridimensionalidad, facilitando la observación de sus variaciones y continuidades. Así, formulo y corroboro tres hipótesis sobre esas crisis: tienden a aumentar o disminuir los niveles de democracia o autocracia de los regímenes o a cambiarlos; la respuesta autocratizante depende de una relación de fuerzas proempresarial que subordina a los trabajadores; y el compromiso democrático de los actores opera contra la autocratización. La contribución a la literatura se relaciona con el modo de abordar los procesos de autocratización y democratización aquí investigados por los impactos de las crisis económicas internacionales en los Estados. Las coyunturas críticas vislumbran componentes clave de la mutabilidad del Leviatán. Se investiga el régimen político a partir de la economía política de las relaciones entre Estado, mercados y clases sociales, y no exclusivamente por las variables político-institucionales. Se analizan mecanismos de intersección de la esfera y de los actores político-institucionales con las estructuras y actores económicos y sociales, que, impactando en la tridimensionalidad del Estado, implican cambios de régimen o en el régimen. comparativo Unidos Brasil 2019 enfocándose principalmente 2008 autoritarias actuales tridimensional coaliciones continuidades Así cambiarlos trabajadores Leviatán sociales políticoinstitucionales. políticoinstitucionales institucionales. institucionales 201 200 20 2

Abstract This study uses a historical-comparative method to examine the impacts of the four international economic crises that occurred until 2019 on the United States, Germany, and Brazil, focusing primarily on their effects on the political regime and the post-2008 period. The selected countries had different authoritarian experiences, either in the distant past or more recently. The State is conceptualized along three dimensions: political regime, decision-making apparatus, and the structure of political domination supported by coalitions. The argument is that the respective international critical junctures tend to impact this three-dimensionality, making it easier to observe their variations and continuities. Three hypotheses are formulated and corroborated regarding these crises: they tend to increase or decrease the levels of democracy or autocracy in regimes or change them; autocratization depends on a pro-business power balance that subordinates workers; the democratic commitment of actors operates against autocratization. This study’s contribution to the literature lies in the approach to processes of autocratization and democratization, which are investigated here through the impacts of international economic crises on States. Critical junctures shed light on key components of the mutability of the Leviathan. It investigates the political regime through the political economy of the relationships between the State, markets, and social classes, not exclusively through political-institutional variables. Mechanisms of intersection between the political-institutional sphere and economic and social structures and actors are analyzed. These mechanisms impact the three-dimensionality of the State, leading to changes in the regime or within the regime. historicalcomparative historical comparative 201 States Germany Brazil post2008 post 2008 post-200 period experiences recently dimensions decisionmaking decision apparatus coalitions threedimensionality, threedimensionality dimensionality, dimensionality continuities them probusiness pro business workers studys s democratization Leviathan markets classes politicalinstitutional institutional variables analyzed 20 post200 200 post-20 2 post20 post-2 post2 post-

Resumo Aborda-se, pelo método histórico-comparativo, impactos, nos Estados dos EUA, Alemanha e Brasil, das quatro crises econômicas internacionais ocorridas até 2019, focando-se, principalmente, em seus efeitos no regime político e no pós-2008. Os países selecionados tiveram distintas experiências autoritárias, remotas ou atuais. Conceituo o Estado tridimensionalmente: regime político, aparato decisor e estrutura de dominação política escorada em coalizões. Argumento que as respectivas conjunturas críticas internacionais tendem a impactar nesta sua tridimensionalidade, facilitando a observação de suas variações e continuidades. Formulo e corroboro três hipóteses sobre essas crises: elas tendem a aumentar ou diminuir os níveis de democracia ou autocracia dos regimes ou a mudá-los; a resposta autocratizante depende de uma relação de forças pró-empresarial, que subordine os trabalhadores; o compromisso democrático dos atores opera contra a autocratização. A contribuição com a literatura está no modo de abordagem dos processos de autocratização e democratização, aqui investigados pelos impactos das crises econômicas internacionais nos Estados. As conjunturas críticas iluminam componentes-chave da mutabilidade do Leviatã. Investiga-se o regime político pela economia política das relações entre Estado, mercados e classes sociais, e não exclusivamente pelas variáveis político-institucionais. Analisam-se mecanismos de intersecção da esfera e dos atores político-institucionais com as estruturas e atores econômicos e sociais, que, impactando na tridimensionalidade do Estado, ensejam mudanças de regime ou no regime. Abordase, Abordase Aborda se, se Aborda-se históricocomparativo, históricocomparativo histórico comparativo, comparativo histórico-comparativo EUA Brasil 2019 focandose, focandose focando focando-se principalmente pós2008. pós2008 pós 2008. 2008 pós-2008 autoritárias atuais tridimensionalmente coalizões continuidades mudálos mudá los mudá-los próempresarial, próempresarial pró empresarial, empresarial pró-empresarial trabalhadores democratização componenteschave componentes chave Leviatã Investigase Investiga sociais políticoinstitucionais. políticoinstitucionais institucionais. institucionais Analisamse Analisam 201 pós200 200 pós-200 20 pós20 pós-20 2 pós2 pós-2 pós-

Résumé Cet article explore la grammaire institutionnelle de la protection des données et de la vie privée au Brésil. En adoptant la perspective analytique de l’Institutional Grammar Tool (IGT), nous déconstruisons les énoncés institutionnels des décrets réglementaires de la Loi Générale sur la Protection des Données des états brésiliens, afin de classifier les différents éléments grammaticaux informant les stratégies étatiques de protection et de gouvernance des données. Nous examinons dans cet article la construction des concepts de protection des données, de gouvernance des données et de vie privée, ainsi que la construction institutionnelle de la protection des données au Brésil. L’étude a une orientation empirique afin de répondre aux questions suivantes: quel est le dessin institutionnel des stratégies adoptées par les états, dans le contexte de la fédération, pour la protection des données personnelles et de la vie privée des citoyens? Quelles sont les implications de ce dessin pour l’efficacité de la protection des données au Brésil? L’article conclut que les stratégies de protection des données formulées au niveau des états sont davantage orientées vers le contrôle bureaucratique du traitement des données que vers la réalisation effective des droits émergents de la citoyenneté. Brésil lInstitutional l Institutional IGT, IGT , (IGT) brésiliens Létude L étude suivantes fédération citoyens lefficacité efficacité Larticle citoyenneté (IGT

Resumen Este artículo investiga la gramática institucional de la protección de datos y de la privacidad en Brasil. Adoptando la perspectiva analítica del Intitutional Grammar Tool (IGT), deconstruimos los enunciados institucionales de los decretos reglamentarios de la Ley General de Protección de Datos de los estados brasileros, con el fin de clasificar los diferentes elementos gramaticales que informaron las estrategias estaduales de protección y gobernanza de datos. Examinamos la construcción de los conceptos de protección de datos, gobernanza de datos y privacidad, así como la construcción institucional de la protección de datos en Brasil. El estudio tiene un abordaje empírico, con el fin de responder a las siguientes cuestiones: ¿cuál es el diseño institucional de las estrategias adoptadas por los estados, en el contexto de la federación, para la protección de datos personales y de la privacidad de los ciudadanos? ¿cuáles son las implicaciones de ese diseño para la efectividad de la protección de datos en Brasil? El artículo concluye que las estrategias de protección de datos formuladas en los estados tienen más un enfoque de control burocrático de tratamiento de datos que propiamente la implementación de derechos emergentes de ciudadanía. Brasil IGT, IGT , (IGT) brasileros empírico cuestiones cuál federación ciudadanos cuáles ciudadanía (IGT

Abstract This article investigates the institutional grammar of data protection and privacy in Brazil. By adopting the analytical lens of the Institutional Grammar Tool (IGT), it deconstructs the institutional statements within the regulatory decrees of the General Data Protection Law (LGPD) in Brazilian states, classifying the different grammatical elements that inform state-level strategies for data protection and governance. It examines how the concepts of data protection, data governance, and privacy are formulated, as well as the institutional construction of data protection in Brazil. By taking an empirical approach, it aims to address the following questions: What is the institutional design of the strategies adopted by Brazilian states, within the federation, to protect personal data and citizens’ privacy? What are the implications of this design on how effective data protection is in Brazil? The article concludes that the data protection strategies formulated by the states lean more toward bureaucratic control of data processing than the actual realization of emerging citizenship rights. Brazil IGT, IGT , (IGT) LGPD (LGPD statelevel state level governance approach questions federation citizens rights (IGT

Resumo Este artigo investiga a gramática institucional da proteção de dados e da privacidade no Brasil. Adotando a lente analítica do Intitutional Grammar Tool (IGT), desconstruímos os enunciados institucionais dos decretos regulamentadores da Lei Geral de Proteção de Dados dos estados brasileiros, de forma a classificar os diferentes elementos gramaticais que informam as estratégias estaduais de proteção e governança de dados. Examinamos nesse artigo a construção dos conceitos de proteção de dados, governança de dados e privacidade, assim como a construção institucional da proteção de dados no Brasil. O estudo tem um viés empírico, de maneira a responder às seguintes questões: qual o desenho institucional das estratégias adotadas pelos estados, no contexto da federação, para a proteção de dados pessoais e da privacidade dos cidadãos? Quais as implicações desse desenho para a efetividade da proteção de dados no Brasil? O artigo conclui que as estratégias de proteção de dados formuladas nos estados têm mais o viés de controle burocrático do tratamento de dados do que propriamente a efetivação de direitos emergentes de cidadania. Brasil IGT, IGT , (IGT) brasileiros empírico questões federação cidadãos cidadania (IGT

Résumé Cet article a pour but de démontrer la pertinence de l´approche transversale des chiffres et des cartes afin de mettre en évidence le pouvoir performatif qui se dégage de leurs intersections tecnhopolitiques telles que le concept de densité de population et la régionalisation du territoire. Appliquée au Brésil, l´étude croisée met en lumière des aspects du processus de construction de l´État, de la centralisation de l´autorité politique et de la création de nouvelles catégories de personnes et d´espaces de gouvernement. Pour ce faire, les tendances qui ont rapproché la statistique et la cartographie au cours de l´Empire brésilien y sont annalysées, en comprenant leur rôle en tant qu´instruments descriptifs du pouvoir souverain. De même, l´article aborde les circonstances qui conduissent à l´importance croissante des chiffres et des cartes comme une référente commune pour l´action collective et la production d´identités sociales. Basé sur le cadre de la sociologie de la quantification, l´article s´intéresse à l´émergence de la cartographie statistique et la régionalisation croissante des données officielles entre les années 1920 et 1940, liée à une nouvelle façon de definir la «brésilité », d´ordonner le territoire et de gouverner la population. On conclut que quantifier, c´est aussi visualiser et imaginer des grandeurs démographiques et économiques dans une spatialité cohérente et unitaire une fois stabilisée par des conventions d´équivalence. lapproche l approche Brésil létude étude lÉtat État l´État lautorité autorité despaces d espaces gouvernement faire lEmpire Empire annalysées quinstruments qu instruments souverain même larticle limportance importance laction action didentités identités sociales quantification sintéresse s intéresse lémergence émergence 192 1940 brésilité » dordonner ordonner quantifier cest c est déquivalence équivalence d´équivalence 19 194 1

Abstract This article takes a cross-disciplinary approach to numbers and maps to demonstrate the performative power that emerges from their technopolitical intersections, such as the concept of population density and regional delineation of territory. Applied to the Brazilian context, this combined analysis sheds light on aspects related to the construction of State authority and its power to create categories of people and places. To do so, this paper examines trends that bring statistics and cartography together in the Brazilian Empire, indicating a common status for maps and numbers as descriptive instruments of sovereign power, including their modes of use and conditions for producing and validating truth. Subsequently, it addresses the factors leading to the growing importance of numbers and maps for collective action and the production of shared identities. Drawing on references from the sociology of quantification, this paper focuses on the emergence of statistical cartography and the increasing regionalization of official data between the 1920s and 1940s – linked to a new way of defining Brazilian identity, organizing territory, and managing population. It concludes that quantifying is also visualizing demographic and economic quantities in a coherent and unitary spatiality, once stabilized by conventions of equivalence. crossdisciplinary cross disciplinary intersections territory context places so Empire truth Subsequently identities quantification s identity spatiality equivalence

Resumen Este artículo realiza un abordaje cruzado de números y mapas con el fin de evidenciar el poder performativo que emerge de sus intersecciones tecnopolíticas, como el concepto de densidad poblacional y el recorte regional del territorio. Aplicado al caso brasilero, el análisis combinado ilustra aspectos relativos a la construcción de la autoridad del Estado y su poder de crear categorías de personas y lugares. Para ese propósito, examinamos las tendencias que aproximan la estadística de la cartografía en Brasil Imperio y que indican un estatuto común a mapas y números como instrumentos descriptivos del poder soberano, sus modalidades de uso y sus condiciones de producción y validación de la verdad. Luego, abordamos los factores que conducen a la creciente importancia de los números y de los mapas para la acción colectiva y para la producción de identidades compartidas. Con base en las referencias de la sociología de la cuantificación, nos enfocamos en la emergencia de la cartografía estadística y en la creciente regionalización de los datos oficiales entre las décadas de 1920 y 1940, vinculadas a un nuevo modo de definir la “brasilidad”, ordenar el territorio y administrar la población. Concluimos que cuantificar es también visualizar cantidades demográficas y económicas en una espacialidad coherente y unitaria, una vez estabilizada por convenciones de equivalencia. tecnopolíticas brasilero lugares propósito soberano verdad Luego compartidas cuantificación 192 1940 brasilidad, brasilidad , “brasilidad” población unitaria equivalencia 19 194 “brasilidad 1

Resumo Este artigo realiza uma abordagem cruzada de números e mapas de modo a evidenciar o poder performativo que emerge de suas interseções tecnopolíticas, como o conceito de densidade populacional e o recorte regional do território. Aplicada ao caso brasileiro, a análise combinada ilumina aspectos relativos à construção da autoridade do Estado e seu poder de criar categorias de pessoas e lugares. Para tanto, examinamos as tendências que aproximam a estatística da cartografia no Brasil Império e que indicam um estatuto comum a mapas e números enquanto instrumentos descritivos do poder soberano, como suas modalidades de uso, e suas condições de produção e validação da verdade. Na sequência, abordamos os fatores que levam à crescente importância dos números e dos mapas para a ação coletiva e para a produção de identidades compartilhadas. Com base nas referências da sociologia da quantificação, enfocamos a emergência da cartografia estatística e a crescente regionalização dos dados oficiais, entre as décadas de 1920 e 1940, ligadas a um novo modo de definir a brasilidade, ordenar o território e gerir a população. Concluímos que quantificar é também visualizar quantidades demográficas e econômicas em uma espacialidade coerente e unitária, uma vez estabilizada por convenções de equivalência. tecnopolíticas brasileiro lugares tanto soberano uso verdade sequência compartilhadas quantificação oficiais 192 1940 brasilidade população unitária equivalência 19 194 1

APPLICATION OF MASS SPECTROMETRY WITH PAPER SPRAY IONIZATION AND THE OPLS-DA CHEMOMETRIC METHOD FOR THE DIAGNOSIS OF PROSTATE CANCER BY ANALYSIS OF URINE SAMPLES. In this study, paper spray ionization mass spectrometry (PSI-MS) allied to orthogonal projections on the latent structure-discrimination analysis (OPLS-DA) was employed to differentiate urine samples from patients with prostate cancer and control individuals (without prostate cancer). The parameters of sensitivity, specificity, efficiency and Matthew’s correlation coefficient determined to analyze the efficiency and quality of the OPLS-DA model obtained a value equal to 1, which means, respectively, that the model has a good performance to correctly classify true positive samples and true negatives. These results showed 100% correct classification of the samples from the training and test set, demonstrating a high efficiency of the OPLS-DA model when classifying all samples considered as belonging to the class of interest (urine from control patient) into class 1 and all samples considered as belonging to the non-interest class (urine from patients with prostate cancer) in class 0. This efficiency resulting from the application of this model suggests that the PSI-MS combined to OPLS-DA is a promisor approach for a rapid diagnosis of prostate cancer, via chemical fingerprints of urine samples. OPLSDA OPLS DA SAMPLES study PSIMS PSI MS (PSI-MS structurediscrimination structure discrimination (OPLS-DA without cancer. . sensitivity specificity Matthews Matthew s means respectively negatives 100 set patient noninterest non 0 10

RESUMO Objetivo: Reconhecer e abordar a síndrome de Patau, apesar de sua raridade e da baixa expectativa de vida associada, por meio da apresentação de um estudo de caso de uma paciente de dois anos que recebe cuidados em casa por intermédio de serviços de home care. Descrição do caso: Apresentamos uma paciente do sexo feminino que desafiou as probabilidades, com sobrevivência prolongada devida, possivelmente, ao home care. Ela nasceu por cesariana, com 31 semanas + 4 dias, em razão da restrição do crescimento uterino. A mãe, de 36 anos, recebeu cuidados pré-natais adequados e gozava de boa saúde. O diagnóstico da síndrome de Patau foi confirmado por meio de cariótipo após o nascimento. Apesar da gravidade clínica do caso, a paciente, hoje com dois anos, recebe atendimento domiciliar especializado, apoiado por traqueostomia e gastrostomia. Um técnico de enfermagem dedicado 24 horas garante acompanhamento contínuo, e a paciente beneficia-se de check-ups médicos regulares, fisioterapia cinco vezes por semana, sessões semanais de fonoaudiologia, consultas mensais com nutricionista e apoio psicológico contínuo aos familiares. Comentários: Esta abordagem multidisciplinar resultou em melhora motora discreta, destacando o impacto positivo do cuidado integral no seu bem-estar geral. A existência de uma rede robusta de apoio às famílias que enfrentam desafios semelhantes é crucial, e um cuidado multidisciplinar pode prevenir eficazmente as complicações associadas a esta impactante síndrome. Objetivo associada care probabilidades devida possivelmente cesariana 3 dias uterino mãe prénatais pré natais saúde nascimento especializado gastrostomia 2 beneficiase beneficia se checkups check ups regulares semana fonoaudiologia familiares Comentários discreta bemestar bem estar geral crucial

ABSTRACT Objective: To recognize and address Patau’s syndrome, despite its rarity and associated low life expectancy, through the presentation of a case study of a 2-year-old patient receiving Home Care services. Case description: We present a female patient who defied the odds with a prolonged survival, possible due to Home Care. She was delivered via cesarean section at 31 weeks + 4 days due to restricted uterine growth. The mother, aged 36, had received proper prenatal care and was in good health. The diagnosis of Patau’s syndrome was confirmed through karyotyping after birth. Despite the severe clinical nature of the case, the patient, now with two years old, receives specialized home-based care, supported by a tracheostomy and gastrostomy. A dedicated 24-hour nursing technician ensures continuous monitoring, and the patient benefits from regular medical check-ups, physiotherapy five times a week, weekly speech therapy sessions, monthly consultations with a nutritionist, and ongoing psychological support for her family members. Comments: This multidisciplinary approach has resulted in a slight motor response, highlighting the positive impact of comprehensive care on her overall well-being. The existence of a robust support network for families facing similar challenges is crucial, and a multidisciplinary care can effectively prevent complications associated with this impactful syndrome. Objective Pataus Patau s expectancy 2yearold yearold 2 year old services description survival 3 growth mother 36 health birth homebased home based gastrostomy 24hour hour 24 monitoring checkups, checkups check ups, ups check-ups week sessions nutritionist members Comments response wellbeing. wellbeing well being. being well-being crucial

ABSTRACT Langerhans cell histiocytosis comprises a heterogeneous range of clinical manifestations secondary to clonal proliferation of histiocytes, characterized by the accumulation of these cells in various organs and tissues. The ophthalmological component commonly involved is the orbit. Herein, we report a rare case of Langerhans cell histiocytosis with eyelid involvement, which resulted in severe ocular surface complications, which subsequently significantly impacted the patient’s quality of life. This case report highlights the fact that despite being rare, Langerhans cell histiocytosis should be included in the differential diagnosis of eyelid lesions. Furthermore, a multidisciplinary approach with a systemic overview is crucial for managing the ocular complications. histiocytes tissues orbit Herein involvement complications patients patient s life lesions Furthermore

ABSTRACT The purpose of this study was to analyze the influence of attention and skepticism in the evaluation of false market discourse with an environmental appeal (greenwashing). The theoretical support for the research was based on the study of the attention process (understood in terms of pre-attention and attention), as well as the practice of greenwashing and consumer skepticism. The methodological procedure adopted a hypothetical-deductive approach, carried out through two face-to-face experiments (n=129 and n=159) with a 2 factorial design (attention/pre-attention) x 2 (present/absent skepticism), with the measurement of four interest metrics (attribute evaluation, judgment about the practice of greenwashing, emotional reaction to the advertisement, and environmental purchase behavior), added to eye tracking. One-way ANOVA was used for one-dimensional analyzes and general linear model (GLM) ANOVA for multivariate analyses, with Tukey's post hoc test. As a result, it was possible to observe a better evaluation of the practice of greenwashing when pre-attentiveness and the absence of skepticism were combined, which sets up a potential scenario for the influence of this false marketing discourse on consumer behavior. greenwashing. . (greenwashing) understood preattention pre attention, , attention) hypotheticaldeductive hypothetical deductive approach facetoface face n=129 n129 n 129 (n=12 n=159 n159 159 attention/preattention attentionpreattention attention/pre (attention/pre-attention present/absent presentabsent present absent skepticism, skepticism) attribute advertisement behavior, behavior behavior) tracking Oneway One way onedimensional one dimensional GLM (GLM analyses Tukeys Tukey s test result preattentiveness attentiveness combined (greenwashing n=12 n12 12 (n=1 n=15 n15 15 attentionpre n=1 n1 1 (n= n= (n

RESUMO O trabalho teve como objetivo analisar a influência da atenção e do ceticismo na avaliação do falso discurso mercadológico com apelo ambiental (greenwashing). O suporte teórico da pesquisa assentou-se no estudo do processo da atenção (compreendido em termos de pré-atenção e atenção), assim como da prática de greenwashing e o ceticismo do consumidor. O procedimento metodológico adotou uma abordagem hipotético-dedutiva, realizada por meio de dois experimentos presenciais (n=129 e n=159) com desenho fatorial 2 (atenção/pré-atenção) x 2 (ceticismo presente/ausente), com a mensuração de quatro métricas de interesse (avaliação dos atributos, julgamento acerca da prática de greenwashing, reação emocional ao anúncio e comportamento ambiental de compra), somada ao monitoramento ocular (eyetracker). Foram empregadas a ANOVA one-way para as análises unidimensionais e a ANOVA pelo modelo linear geral (GLM) para as análises multivariadas, com o teste post hoc de Tukey. Como resultado, foi possível observar uma melhor avaliação da prática de greenwashing quando da junção da pré-atenção e da ausência do ceticismo, o que configura um cenário de potencialidade da capacidade de influência desse falso discurso mercadológico no comportamento do consumidor. greenwashing. . (greenwashing) assentouse assentou se compreendido préatenção pré atenção, , atenção) consumidor hipotéticodedutiva, hipotéticodedutiva hipotético dedutiva, dedutiva hipotético-dedutiva n=129 n129 n 129 (n=12 n=159 n159 159 atenção/préatenção atençãopréatenção atenção/pré (atenção/pré-atenção presente/ausente, presenteausente presente/ausente presente ausente presente/ausente) atributos compra, compra compra) eyetracker. eyetracker (eyetracker) oneway one way GLM (GLM multivariadas Tukey resultado (greenwashing n=12 n12 12 (n=1 n=15 n15 15 atençãopré (eyetracker n=1 n1 1 (n= n= (n

ABSTRACT Desertification is the degradation process caused by climatic conditions and human activities that results in loss of soil productivity and decline in vegetation growth in the long term. Several indices related to vegetation, soil and climate are used to monitor desertification, but few studies explore qualitative and quantitative aspects of indices on desertification on spatial and hierarchical scale. This study aims to identify and measure indices related to increased risk of desertification on global, local and hierarchical scales using multinomial logistic regression models. Images from TM, ETM+ and OLI sensor from 1997 to 2018 in the end of dry and rainy seasons were used to quantify NDVI, TGSI, albedo, temperature, aridity index, evapotranspiration and precipitation on global spatial scale (Irauçuba Centro Norte) and local spatial scale (Miraíma, Canindé, Irauçuba and Santa Quitéria). GISD was calculated by geometric mean of weighted indices and segmented into 8 classes of susceptibility to desertification (hierarchical scale). The results showed that the best models were obtained on local scale and for the end of the rainy season. Temperature proved to be the most important variable for increased risk of desertification on global, local and hierarchical scales. Therefore, the increase in the risk of desertification in the studied areas is due to human activities of deforestation, overgrazing and fire. These factors contributed to reduction of vegetation cover and increase in temperature, changing the microclimatic, which led to decline in precipitation and worsening of desertification. term TM ETM 199 201 NDVI TGSI albedo temperature index Norte Miraíma, Miraíma (Miraíma Canindé Quitéria. Quitéria . Quitéria) scale) season Therefore deforestation fire microclimatic 19 20 1 2

It is well known that during times of social unrest, replacing the constitution is one of the first proposals to emerge, at least in Latin America, as if this constitutional shift could resolve any problem. Constitutional substitution is not a new phenomenon in Latin America; it actually began after the region’s redemocratization. However, it is striking that, despite similar conditions of social unrest, many other countries in the region have not undergone such an encompassing constitutional reform. Our main focus here is to analyze the persistence of constitutions in Latin American countries. We thus ask: What conditions lead democratic countries to keep their constitutions? Using a configurational approach, our preliminary results are promising. Together, four pathways explain why some countries have not replaced their constitutions in democratic contexts, with special emphasis on the number of rights enshrined in these fundamental laws. unrest emerge America problem regions s redemocratization However reform ask approach promising Together contexts laws

This study presents a solution to solid waste problems, focusing on spent lithium-ion batteries (LiBs) and iron ore tailings (IOT) from the Mariana environmental accident in Brazil. The approach involves the production CoFe2O4 from LiBs and IOT, which serves as a catalyst for solar photo-Fenton reactions for methylene blue (MB) decolorization and as an electrochemical sensor for ascorbic acid (AA) detection. Chemical analysis showed recycling potential, with 45.22 ± 0.22% m m−1 Co from LiBs and 14.9 ± 1.5% m m−1 Fe from IOT, determined by inductively coupled plasma atomic emission spectroscopy (ICP OES) and flame atomic absorption spectrometry (FAAS). The sol-gel synthesized CoFe2O4 exhibited a crystallite size of 51.9 ± 1.3 nm and agglomerated crystal clusters. Recycled-CoFe2O4 exhibited a 98.1% MB decolorization efficiency in 60 min under solar irradiation and remained above 92.3% in all 7 reuse cycles. The electrochemical sensor exhibited a coefficient of determination of 0.9987, a sensitivity of 3.352 ± 0.0428 μA mol L−1, and a limit of detection of 0.5511 µM in the concentration range of 1.96 to 23.08 mmol L−1 for AA detection. This study demonstrates the potential of recycled-CoFe2O4 in an environmentally friendly dye removal and as an electrochemical sensor, offering sustainable waste management and resource utilization with solar energy. problems lithiumion lithium ion (LiBs IOT (IOT Brazil CoFeO CoFe O CoFe2O photoFenton photo Fenton (MB (AA 4522 45 22 45.2 022 0 0.22 m1 1 m− 149 14 9 14. 15 5 1.5 ICP OES FAAS. FAAS . (FAAS) solgel sol gel 519 51 51. 13 3 1. clusters RecycledCoFe2O4 RecycledCoFeO Recycled Recycled-CoFe2O 981 98 98.1 6 923 92 92.3 cycles 09987 9987 0.9987 3352 352 3.35 00428 0428 0.042 L1 L 05511 5511 0.551 196 96 1.9 2308 23 08 23.0 L− recycledCoFe2O4 recycledCoFeO recycled recycled-CoFe2O energy 452 4 2 45. 02 0.2 (FAAS RecycledCoFe RecycledCoFe2O 98. 92. 0998 998 0.998 335 35 3.3 0042 042 0.04 0551 551 0.55 19 230 23. recycledCoFe recycledCoFe2O 0. 099 99 0.99 33 3. 004 04 0.0 055 55 0.5 09 0.9 00 05

Brazilian Savanna biodiversity is abundant in native fruits with nutritional and sensory properties with potential technological applications. However, the information available regarding the proprieties of Brazilian native fruits is still limited. This study aimed to analyze the metabolic profile of Brosimum gaudichaudii fruits (BGF) using metabolomics approaches, besides its physicochemical and nutritional proprieties. BGF exhibited protein content at least two times higher than other native fruits. Fifty-five metabolites were identified by the metabolomics approaches, mainly fatty acids (n = 22), carbohydrates (n = 13), organic acids (n = 6), and polyphenols (n = 5). The most abundant constituents were D-fructose (42.97%) for sugars, L-asparagine (6.47%) for amino acids, succinic acid (44.11%) for organic acids, and linolenic acid (3.04%) for fatty acids. Highlighted phytochemicals included chlorogenic acid, α-amyrin, and γ-tocopherol. Additionally, this study revealed that BGF is a good source of vitamin C and dietary fiber and an excellent source of vitamin A. Future studies providing nutritional information and suggesting consumption methods and potential industrial applications are essential to familiarize consumers with these foods. Additionally, clarifying the appropriate planting and harvesting seasons can revive traditional practices, especially for native fruits like BGF. However limited (BGF approaches Fiftyfive Fifty five n 22, 22 , 22) 13, 13 13) 6, 6 6) 5. 5 . 5) Dfructose D fructose 42.97% 4297 42 97 (42.97% sugars Lasparagine L asparagine 6.47% 647 47 (6.47% 44.11% 4411 44 11 (44.11% 3.04% 304 3 04 (3.04% αamyrin, αamyrin α amyrin, amyrin α-amyrin γtocopherol. γtocopherol γ tocopherol. tocopherol γ-tocopherol Additionally A foods practices 2 1 42.97 429 4 9 (42.97 6.47 64 (6.47 44.11 441 (44.11 3.04 30 0 (3.04 42.9 (42.9 6.4 (6.4 44.1 (44.1 3.0 (3.0 42. (42. 6. (6. 44. (44. 3. (3. (42 (6 (44 (3 (4 (

Alzheimer’s disease (AD) is a most common form of dementia and results in memory loss, disorientation, impaired thinking and changes in personality as well as mood. The dementia cases mostly turn into the Alzheimer’s disease (AD). Another disease, the Parkinson’s disease (PD), mainly affects dopaminergic neurons in substantia nigra. A series of previously synthesized quinolone-triazole hybrids were investigated and evaluated for their anti-acetyl cholinesterase and against monoamine oxidase reactive properties through in silico characterization. The ground state electronic properties were determined by electron density of the compounds through DFTs (density functional theory) calculation. The geometries of all compounds were optimized using Becke-3-parameter-Lee-Yang-Parr (B3LYP) method and 6-311g basis set. Docking studies were conducted using the AutoDock and Molecular Operating Environment (MOE) software and the results of the potent derivatives found to be encouraging. The data confirmed that all the compounds have drug-like properties and was further confirmed by ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. Alzheimers Alzheimer s AD (AD loss disorientation mood AD. . Parkinsons Parkinson PD, PD , (PD) nigra quinolonetriazole quinolone triazole antiacetyl anti acetyl characterization theory calculation Becke3parameterLeeYangParr BeckeparameterLeeYangParr Becke 3 parameter Lee Yang Parr B3LYP BLYP B LYP (B3LYP 6311g g 6 311g set MOE (MOE encouraging druglike drug like absorption, absorption (absorption distribution metabolism toxicity (PD parameterLeeYangParr

ABSTRACT A patient presented with corneoscleral thinning five months after the treatment of suspected ocular squamous surface neoplasia with mitomycin-C and interferon. For tectonic and aesthetic purposes, we decided to perform lamellar corneoscleral transplantation. The approach used established new tectonic support and corneal homeostasis. This technique might be an option in similar cases. mitomycinC mitomycin C interferon purposes transplantation homeostasis cases

Even though ammonia is a natural component of aquatic environments, elevated concentrations indicate pollution and environmental degradation. Consequently, efficient analytical methods for monitoring ammonia levels are crucial for preserving water quality. Voltammetry offers a sustainable approach for NH3 quantification, combining good analytical performance with low sample and reagent consumption, minimizing waste generation. However, despite these advantages, the voltammetric determination of ammonia remains relatively unexplored. Therefore, this study investigated the electrochemical behavior of NH3 in alkaline solutions using a non-modified Pt electrode and evaluated the performance of differential pulse voltammetry (DPV) and square wave voltammetry (SWV) for NH3 determination. DPV provided superior performance, with limits of detection and quantification of 0.79 µmol L-1 (0.011 ppmN) and 2.6 µmol L-1 (0.036 ppmN), respectively, which comply with the maximum allowable ammonia concentration in natural waters according to Brazilian and European regulations. The voltammetric method successfully quantified ammonia in tap and river water samples, providing results concordant with the established Berthelot spectrophotometric method, at a 95% confidence level. Additionally, it is simple and fully accessible to non-electrochemist since no sophisticated procedures for electrode modification are needed. Finally, the high analytical performance of the proposed method makes it valuable for pollution monitoring in aquatic environments. environments degradation Consequently quality NH consumption generation However advantages unexplored Therefore nonmodified non modified (DPV SWV (SWV 079 0 79 0.7 L1 L 1 L- 0.011 0011 011 (0.01 ppmN 26 2 6 2. 0.036 0036 036 (0.03 ppmN, , respectively regulations samples 95 level Additionally nonelectrochemist electrochemist needed Finally 07 7 0. 0.01 001 01 (0.0 0.03 003 03 9 0.0 00 (0. (0 (