Gold and platinum bimetallic nanoparticles, Au@PtNPs, have gained attention due to their plasmonic properties. The controlled synthesis of Au@PtNPs involves complex parameters, and the resulting synergy between Au and Pt introduces possibilities for tailoring their properties. This study explores the effects of key-parameters of synthesis (gold core diameters, reaction time, and Pt concentration) on the final properties of Au@PtNPs. Gold nanoparticles of varying diameters were synthesized and used as cores for the reduction of hexachloroplatinic acid, forming a surrounding shell of Pt nanoparticles. The parameters were systematically tuned to understand their impact on morphology, dimension, stability, and plasmonic properties of Au@PtNPs. Increasing Pt precursor concentration resulted in thicker and denser Pt shells, broadening the localized surface plasmon resonance (LSPR) band and improving Au@PtNPs stability. These properties are essential for applications such as photothermal treatment. The synthesis achieved satisfactory products within just 1 h of Pt4+ reduction at mild temperature without using surfactants. Only limited changes in plasmonic properties were observed after 4 h of synthesis, suggesting an optimal reaction period. Manipulating Au core diameter provided LSPR band control, with smaller cores exhibiting greater broadening towards the infrared region. This systematic exploration provided valuable insights for understanding key-parameters governing the synthesis and properties of Au@PtNPs. AuPtNPs PtNPs keyparameters key gold time acid morphology dimension stability shells (LSPR treatment Pt4 surfactants period control region

The present work focused on the screening process of different inorganic oxides and different temperatures for the epoxidation reaction of macaw palm vegetable oil without using solvent, a promising Brazilian biomass that can substitute other vegetable oils (e.g., soybean oil) in technological applications. This oil has an iodine value of 108.48 g of I2 per 100 g being categorized as a semi-dry oil. The epoxidized vegetable oil can be applied in manifold areas in polymer science. The epoxidation reaction here presented avoided organic solvents and organic acids and aimed to produce a greener route using metal oxides or niobium phosphate as a peroxide-activating catalyst. The experimental parameters were maintained as 10 mol% of catalyst loading and a time of 24 h; however, the temperature for some catalysts was changed to improve the epoxide conversion. Experiments were measured by proton nuclear magnetic resonance (1H NMR). Experiments using titanium oxide (TiO2) as a catalyst reached a conversion greater than 84.7%, while experiments using aluminium oxide (Al2O3) or lanthanum oxide (La2O3) achieved conversions of 22.6 and 30.1%, respectively. Furthermore, it was observed that both niobium compounds instantly react with hydrogen peroxide to form peroxy derivatives. solvent e.g., eg e (e.g. applications 10848 108 48 108.4 I semidry semi dry science peroxideactivating activating 1 mol 2 h however 1H H NMR. NMR . NMR) TiO2 TiO (TiO2 847 84 7 84.7% Al2O3 AlO Al O (Al2O3 La2O3 LaO La (La2O3 226 22 6 22. 301 30 30.1% respectively Furthermore derivatives e.g. (e.g 1084 4 108. (TiO 8 84.7 Al2O (Al2O La2O (La2O 3 30.1 e.g 84. 30.

Schiff bases are diverse organic compounds with an azomethine structure (–C=N–), holding potential in both chemistry and biology. They serve as catalysts, stabilizers, and exhibit various biological activities. The molecular structure of Schiff bases influences their biological properties, including antimicrobial effects. Redox-active compounds with more negative potentials tend to be more effective against microbes. In one of our recent studies, we explored the antimicrobial properties of two Schiff bases derivatives, SB-1 ((E)-4-amino-3-((3,5-di-tert-butyl-2-hydroxybenzylidene)amino) and SB-2 ((E)-2-((4-nitrobenzilidene)amino)aniline). SB-1 showed antibacterial activity against certain Gram-positive bacteria, while SB-2 did not. The difference in their cyclic voltametric profiles, especially SB-1’s more negative reduction potential, prompted us to carry out further characterizations, including scan-rate studies, solvent analysis, and computational calculations. We found that SB-1, which presents a stable intramolecular hydrogen bond, undergoes irreversible oxidation, likely at the –NH2 group, and a quasi-reversible reduction via an intramolecular reductive coupling of the (–C=N–) azomethine group, supported by orbital theoretical calculations. This research sheds light on the potential applications of Schiff bases in antimicrobial contexts, guided by their redox properties and structure. –C=N–, CN –C=N– , C N biology catalysts stabilizers activities effects Redoxactive Redox active microbes studies derivatives SB1 SB 1 SB- E4amino33,5ditertbutyl2hydroxybenzylideneamino E4amino335ditertbutyl2hydroxybenzylideneamino Eaminoditertbutylhydroxybenzylideneamino E 4 amino 3 3,5 di tert butyl 2 hydroxybenzylidene 5 ((E)-4-amino-3-((3,5-di-tert-butyl-2-hydroxybenzylidene)amino SB2 E24nitrobenzilideneaminoaniline. E24nitrobenzilideneaminoaniline Enitrobenzilideneaminoaniline nitrobenzilidene aniline . ((E)-2-((4-nitrobenzilidene)amino)aniline) Grampositive Gram positive bacteria not profiles SB1s SBs s characterizations scanrate scan rate analysis calculations SB1, 1, bond oxidation NH2 NH –NH group quasireversible quasi reversible (–C=N– contexts –C=N E4amino33 5ditertbutyl2hydroxybenzylideneamino ditertbutyl hydroxybenzylideneamino 35 3, nitrobenzilideneaminoaniline ((E)-2-((4-nitrobenzilidene)amino)aniline (–C=N Eamino E4amino3 ditertbutylhydroxybenzylideneamino E4amino

This review provides an overview of the recent progress in organic electrosynthesis in Brazil, ranging from 2013 to 2023. By highlighting the principles, applications, and limitations of various electrosynthetic methodologies, this article aims to contribute to the understanding of basic principles and stimulate research in this field in Brazil. Moreover, the limitations and challenges associated with organic electrosynthesis are covered. Factors such as electrode material selection, solvent effects, and reaction optimization are discussed, highlighting the need for further research and development to overcome these obstacles. Finally, future prospects are outlined. Brazil 201 2023 applications methodologies Moreover covered selection effects discussed obstacles Finally outlined 20 202 2

High-density polyethylene (HDPE) geomembranes are commonly used as an environmental protection liner due to their good chemical and mechanical resistances and low cost. Ultraviolet (UV) radiation is an essential issue in durability studies for pond applications. This study evaluated a 1.5-mm thick HDPE geomembrane exposed to ultraviolet fluorescent radiation for 8760 h in a laboratory and thermoanalytical and physical analyses were conducted towards the understanding of its performance after exposure. According to the results, although the geomembrane maintained the ductile behavior, it showed a 52.48% final decrease in stress crack resistance (SCR) compared to virgin SCR. Moreover, a considerable antioxidant depletion occurred after 8760 h exposure shown by the Std. OIT (standard oxidative-induction time) results, demonstrating a Std. OIT value decrease of 89.19% compared to the virgin Std. OIT. Such a behavior contributed to the susceptibility of thermal effects in the DSC (differential scanning calorimetry) curves and the losses observed in the SCR values, attesting the geomembrane’s oxidative degradation mechanism occurred and changed the polymer’s structure. Highdensity High density (HDPE cost UV (UV applications 1.5mm 15mm mm 1.5 1 5 876 results 5248 52 48 52.48 (SCR Moreover Std standard oxidativeinduction induction time 8919 89 19 89.19 differential calorimetry values s polymers polymer structure 5mm 15 1. 87 524 4 52.4 891 8 89.1 52. 89.

Chemometrics is gaining more and more space in universities and industry. To contribute to the development and expansion of principal component analysis (PCA) teaching proposals, this work evaluated the answers of the students to a questionnaire and presented a didactic-pedagogical proposal that can contribute to solving the principal doubts achieved by students in the PCA interpretation. Based on data collected in a semi-open questionnaire, the proposal was developed based on methodological principles of historical-critical pedagogy, containing the objectives, the problems surrounding the topic, and the cultural instruments necessary for understanding and interpreting PCA in the discipline of chemometrics by using new resources and instruments, especially free software, Chemostat. This proposal covers topics related to the concept of chemometrics and PCA, the explanation of the data set, pre-processing, use of Chemostat software, and analysis of principal components. It is hoped that this proposal can promote a better understanding concerning PCA on the part of students, as well as effective incorporation of the phenomena that involve this tool and its applications, and interpretation. Likewise, it is expected that this didactic-pedagogical proposal can support new teaching practices in chemometrics subjects in higher education. industry (PCA proposals didacticpedagogical didactic pedagogical interpretation semiopen semi open historicalcritical historical critical pedagogy objectives topic software set preprocessing, preprocessing pre processing, processing pre-processing components applications Likewise education

In recent years, the field of coordination chemistry has experienced a surge in interest regarding the synthesis and characterization of coordination complexes for diverse applications. This study is dedicated to investigating coordination compounds resulting from the interaction of nonsteroidal anti-inflammatory drugs (NSAIDs) with metal ions. The study research places significant emphasis on understanding the stability and thermal behavior of these coordination compounds. The utilization of thermoanalytical techniques is crucial in achieving this goal. Thermal analysis and thermokinetics provide valuable insights into the underlying mechanisms, kinetics, and energetics of these reactions, thereby facilitating the optimization of synthesis procedures. The research employs concurrent techniques, namely thermogravimetric analysis (TG) and differential scanning calorimetry (DSC), to explore the thermal stability and decomposition pathways of these coordination compounds. Thermokinetic models and optimization methodologies are subsequently applied to identify key reaction parameters. The primary aim of this research is to unveil the thermal behavior, stability, and reaction kinetics of aceclofenac coordination compounds, thus contributing significantly to the understanding of thermokinetics and thermal analysis in the domain of coordination chemistry. Specifically, this study is focused on aceclofenac coordination complexes involving lanthanum and gadolinium, with the ultimate goal of advancing the field of coordination chemistry. years applications antiinflammatory anti inflammatory NSAIDs (NSAIDs ions mechanisms reactions procedures TG (TG DSC, DSC , (DSC) parameters Specifically gadolinium (DSC

This study presents a solution to solid waste problems, focusing on spent lithium-ion batteries (LiBs) and iron ore tailings (IOT) from the Mariana environmental accident in Brazil. The approach involves the production CoFe2O4 from LiBs and IOT, which serves as a catalyst for solar photo-Fenton reactions for methylene blue (MB) decolorization and as an electrochemical sensor for ascorbic acid (AA) detection. Chemical analysis showed recycling potential, with 45.22 ± 0.22% m m−1 Co from LiBs and 14.9 ± 1.5% m m−1 Fe from IOT, determined by inductively coupled plasma atomic emission spectroscopy (ICP OES) and flame atomic absorption spectrometry (FAAS). The sol-gel synthesized CoFe2O4 exhibited a crystallite size of 51.9 ± 1.3 nm and agglomerated crystal clusters. Recycled-CoFe2O4 exhibited a 98.1% MB decolorization efficiency in 60 min under solar irradiation and remained above 92.3% in all 7 reuse cycles. The electrochemical sensor exhibited a coefficient of determination of 0.9987, a sensitivity of 3.352 ± 0.0428 μA mol L−1, and a limit of detection of 0.5511 µM in the concentration range of 1.96 to 23.08 mmol L−1 for AA detection. This study demonstrates the potential of recycled-CoFe2O4 in an environmentally friendly dye removal and as an electrochemical sensor, offering sustainable waste management and resource utilization with solar energy. problems lithiumion lithium ion (LiBs IOT (IOT Brazil CoFeO CoFe O CoFe2O photoFenton photo Fenton (MB (AA 4522 45 22 45.2 022 0 0.22 m1 1 m− 149 14 9 14. 15 5 1.5 ICP OES FAAS. FAAS . (FAAS) solgel sol gel 519 51 51. 13 3 1. clusters RecycledCoFe2O4 RecycledCoFeO Recycled Recycled-CoFe2O 981 98 98.1 6 923 92 92.3 cycles 09987 9987 0.9987 3352 352 3.35 00428 0428 0.042 L1 L 05511 5511 0.551 196 96 1.9 2308 23 08 23.0 L− recycledCoFe2O4 recycledCoFeO recycled recycled-CoFe2O energy 452 4 2 45. 02 0.2 (FAAS RecycledCoFe RecycledCoFe2O 98. 92. 0998 998 0.998 335 35 3.3 0042 042 0.04 0551 551 0.55 19 230 23. recycledCoFe recycledCoFe2O 0. 099 99 0.99 33 3. 004 04 0.0 055 55 0.5 09 0.9 00 05

Brazilian Savanna biodiversity is abundant in native fruits with nutritional and sensory properties with potential technological applications. However, the information available regarding the proprieties of Brazilian native fruits is still limited. This study aimed to analyze the metabolic profile of Brosimum gaudichaudii fruits (BGF) using metabolomics approaches, besides its physicochemical and nutritional proprieties. BGF exhibited protein content at least two times higher than other native fruits. Fifty-five metabolites were identified by the metabolomics approaches, mainly fatty acids (n = 22), carbohydrates (n = 13), organic acids (n = 6), and polyphenols (n = 5). The most abundant constituents were D-fructose (42.97%) for sugars, L-asparagine (6.47%) for amino acids, succinic acid (44.11%) for organic acids, and linolenic acid (3.04%) for fatty acids. Highlighted phytochemicals included chlorogenic acid, α-amyrin, and γ-tocopherol. Additionally, this study revealed that BGF is a good source of vitamin C and dietary fiber and an excellent source of vitamin A. Future studies providing nutritional information and suggesting consumption methods and potential industrial applications are essential to familiarize consumers with these foods. Additionally, clarifying the appropriate planting and harvesting seasons can revive traditional practices, especially for native fruits like BGF. However limited (BGF approaches Fiftyfive Fifty five n 22, 22 , 22) 13, 13 13) 6, 6 6) 5. 5 . 5) Dfructose D fructose 42.97% 4297 42 97 (42.97% sugars Lasparagine L asparagine 6.47% 647 47 (6.47% 44.11% 4411 44 11 (44.11% 3.04% 304 3 04 (3.04% αamyrin, αamyrin α amyrin, amyrin α-amyrin γtocopherol. γtocopherol γ tocopherol. tocopherol γ-tocopherol Additionally A foods practices 2 1 42.97 429 4 9 (42.97 6.47 64 (6.47 44.11 441 (44.11 3.04 30 0 (3.04 42.9 (42.9 6.4 (6.4 44.1 (44.1 3.0 (3.0 42. (42. 6. (6. 44. (44. 3. (3. (42 (6 (44 (3 (4 (

Over the last two decades, metabolomics has emerged as a pivotal tool in multidisciplinary research, providing invaluable insights into metabolome modulations and finding applications across various scientific domains, including medicine and agronomy. Nonetheless, the absence of standardized procedures in sample preparation, data acquisition, and documentation of data quality presents a significant challenge. This review underscores the critical importance of quality assurance and quality control (QA/QC) in untargeted metabolomics, advocating for the establishment of agreed-upon QA/QC reporting standards within the scientific community. We discuss the requisite quality controls at various stages of untargeted metabolomics studies, encompassing blank samples, pooled samples, and the utilization of external quality control samples. Methods for assessing accuracy, reproducibility, and identifying/correcting batch effects are addressed. Furthermore, emphasis is placed on standardizing the description of QA/QC data in scientific publications and repositories to foster reproducibility and transparency. We recommend the publication of QC data alongside studies in appropriate databases to facilitate data comparison and sharing among researchers, thereby enhancing the quality of untargeted metabolomics research. In summary, implementing standardized QA/QC data reporting, along with promoting best practices within the untargeted metabolomics community, is crucial for improving result quality and credibility and advancing research utilizing this powerful technique. decades domains agronomy Nonetheless preparation acquisition challenge QAQC QA (QA/QC agreedupon agreed upon community samples accuracy identifyingcorrecting identifying correcting addressed Furthermore transparency researchers summary technique

The history of the discovery, use, and development of dyes is closely linked to the history of humanity itself. Among the first records of human civilization are cave paintings made from, e.g., fruits, plants, minerals, and insects. Over the centuries, using different techniques, colors have been given to all types of materials and products, from clothing to food. The chemicals responsible for colors are dyes - a vast collection of molecules of the most varied compositions, but which have in common the absorption of light within the visible window of the electromagnetic spectrum. This article aims not only to review the properties of some classes of natural dyes, their origins, and their applications but also to describe the various computational chemistry methods involved in designing new bio-inspired molecules. discovery use itself eg e g e.g. fruits plants minerals insects centuries techniques products food compositions spectrum origins bioinspired bio inspired e.g

This study expands and shows the versatility of applications in hydrophilic interaction chromatography coupled with triple quadrupole mass spectrometry (HILIC-MS/MS) using a FRULIC-N column to determine 31 phenolic compounds in beverage industry residues (coffee, apple juice, beer, and wine). Optimization, via Doehlert design, determined the acetonitrile proportion (50-90%) and pH (3.0-7.0) in the mobile phase (MP). A 22 factorial design assessed the concentration of ammonium acetate (10-110 mmol L-1) in the MP and column temperature (20-60 °C). Injection volume (5-45 µL) was univariately optimized. Separations at 60 °C reduced chromatographic run time to less than 11 min. Gradient elution (500 µL min-1) employed an MP comprising acetonitrile and ammonium acetate (110 mmol L-1, pH 7). Validation demonstrated average coefficient of determination (R2) 0.9707, limit of detection 0.001-0.503 mg L-1 and quantification 0.004-1.524 mg L-1, precision < 12.2%, recovery 92.4-110.8%. The method was applied to five residues, indicating its viability for determining phenolics in beverage production residues. HILICMS/MS HILICMSMS HILIC MS/MS MS (HILIC-MS/MS FRULICN FRULIC N 3 coffee, coffee (coffee juice beer wine. wine . wine) Optimization 5090% 5090 50 90% 90 (50-90% 3.07.0 3070 3.0 7.0 0 7 (3.0-7.0 MP. (MP) 2 10110 10 110 (10-11 L1 L 1 2060 20 (20-6 °C. C °C) 545 5 45 (5-4 optimized 6 min 500 (50 min1 min-1 (11 L1, 1, 7. 7) R2 R (R2 09707 9707 0.9707 0.0010.503 00010503 0.001 0.503 001 503 0.001-0.50 L- 0.0041.524 00041524 0.004 1.524 004 524 0.004-1.52 122 12 12.2% 92.4110.8%. 9241108 92.4 110.8%. 92 4 8 92.4-110.8% HILICMS MSMS 509 9 (50-90 07 3.07. 307 30 3. 70 (3.0-7. (MP 1011 (10-1 206 (20- 54 (5- (5 min- (1 (R 0970 970 0.970 0010 0.0010.50 0001050 0001 0.00 0503 0.50 00 0.001-0.5 0041 0.0041.52 0004152 0004 1524 1.52 52 0.004-1.5 12.2 4110 92.4110.8% 924110 924 92. 1108 110.8% 92.4-110.8 (50-9 3.07 (3.0-7 101 (10- (20 ( 097 97 0.97 0.0010.5 000105 000 0.0 050 0.5 0.001-0. 0.0041.5 000415 152 1.5 0.004-1. 12. 411 92.4110.8 92411 110.8 92.4-110. (50- (3.0- (10 (2 09 0.9 0.0010. 00010 0. 05 0.001-0 0.0041. 00041 15 1. 0.004-1 41 92.4110. 9241 110. 92.4-110 (3.0 0.0010 0.001- 0.0041 0.004- 92.4110 92.4-11 (3. 92.411 92.4-1 (3 92.41 92.4-

RESUMO O balanço hídrico é uma ferramenta com diversas aplicações na agricultura, incluindo a avaliação da adequação de um ambiente para o cultivo de uma determinada cultura, através da compreensão de como os recursos hídricos operam no sistema. Esta informação é vital para determinar se a água disponível satisfaz a necessidade da cultura. Assim, objetivou-se calcular o balanço hídrico em um Argissolo Vermelho-Amarelo para o cultivo de Coffea canephora no município de Cruzeiro do Sul, Acre, utilizando uma série histórica de 36 anos para avaliar o potencial e as restrições da cultura de acordo com a água disponível. Os resultados mostraram que, de forma geral, o cultivo de Coffea canephora é adequado para a região de estudo. Os períodos de déficit hídrico e de excesso de água são bem definidos, ocorrendo de abril a agosto e de setembro a março, respectivamente. Verificou-se que apenas a fase de floração do cafeeiro coincide com o período de déficit hídrico na região, exigindo assim irrigação para evitar comprometer essa etapa do desenvolvimento do fruto. Em relação ao Indice de Satisfação da Necessidade de Água (ISNA), observou-se que, quando calculado em uma escala mensal, indica baixo risco climático para o cultivo de Coffea canephora na região. No entanto, quando calculado em uma escala diária, o ISNA indica risco climático médio a alto para o cultivo durante vários períodos. O ISNA mostrou ser uma ferramenta adequada para a tomada de decisão quanto à adoção de técnicas de irrigação. agricultura sistema Assim objetivouse objetivou VermelhoAmarelo Vermelho Amarelo Sul Acre 3 geral estudo definidos março respectivamente Verificouse Verificou fruto ISNA, , (ISNA) observouse observou mensal entanto diária (ISNA

ABSTRACT Water balance is a tool that has various applications in agriculture, including assessing whether an environment is suitable for growing a specific crop by providing information on how water resources function in the system. This information is essential for determining whether the available water satisfies the crop’s demand. Thus, the objective of this work was to calculate the water balance of Typic Hapludults for growing coffee (Coffea canephora) crops in Cruzeiro do Sul, Acre, Brazil, using a 36-year historical series to assess the potential and limitation of the crop according to the water availability. The results showed that coffee crops are, in general, suitable for growing in the study region. Water deficit and water surplus periods are well-defined, from April to August and September to March, respectively. Flowering was the only stage of coffee crops that coincides with the water deficit period in the region; thus, irrigation is necessary to prevent compromising this stage and fruit development. The Water Requirement Satisfaction Index (WRSI), calculated on a monthly basis, indicates a low climate risk for coffee crops in the region. However, when calculated on a daily basis, the WRSI shows a medium to high climate risk for coffee crops in several periods. The WRSI proved to be an adequate tool for assisting in decision-making regarding the adoption of irrigation. agriculture system s demand Thus Coffea canephora Sul Acre Brazil 36year year 36 availability general region welldefined, welldefined well defined, defined well-defined March respectively thus development WRSI, , (WRSI) basis However decisionmaking decision making 3 (WRSI

RESUMO A introdução da soja tolerante a 2,4-D (ENLIST®) oferece um novo potencial para a aplicação de herbicidas. Dessa forma, o presente trabalho teve como objetivo: (a) avaliar o efeito das combinações de herbicidas pós-emergentes no controle de Conyza spp., e (b) a seletividade da associação de herbicidas pós-emergentes em soja, garantindo uma aplicação eficaz sem comprometer a saúde da cultura. Um experimento de campo com soja tolerante ao 2,4-D utilizou um delineamento experimental de blocos casualizados, com 14 tratamentos em quatro repetições. Os tratamentos incluíram várias combinações de 2,4-D com glifosato, chlorimuron, cloransulam, imazethapyr, bentazona e imazamox. Estes foram aplicados como um único tratamento ou sequencialmente 15 dias após o tratamento (DAT) usando glufosinato de amônio, juntamente com dois controles sem aplicação de herbicida. Os resultados mostraram menos de 15% de fitotoxicidade em todos os tratamentos. Aos 21 DAT, apenas os tratamentos aplicados sequencialmente mostraram controle significativo, com eficácia superior a 80% contra Conyza spp. Em contraste, as aplicações únicas das combinações de herbicidas com 2,4-D foram ineficazes para o controle pós-emergência de Conyza spp. 2,4D 24D D 2,4 2 4 ENLIST® ENLIST (ENLIST® forma objetivo (a pósemergentes pós emergentes spp b (b cultura casualizados 1 repetições glifosato chlorimuron cloransulam imazethapyr imazamox DAT (DAT amônio herbicida significativo 80 contraste pósemergência emergência 4D 24 2, (ENLIST 8

ABSTRACT The introduction of 2,4-D-tolerant soybeans (ENLIST®) offers a new potential for herbicide application. Therefore, the present study aimed to (a) evaluate the effect of combinations of post-emergent herbicides on the control of Conyza spp. and (b) assess the selectivity of the post-emergent herbicide association in soybeans, ensuring effective application without compromising the health of the crop. A field experiment with 2,4-D-tolerant soybeans utilized a randomized complete block design with 14 treatments across four replications. Treatments included various combinations of 2,4-D with glyphosate, chlorimuron-ethyl, cloransulam-methyl, imazethapyr, bentazon, and imazamox. These were applied either as a single treatment or sequentially 15 days after treatment (DAT) using glufosinate-ammonium alongside two controls without herbicide application. The results showed less than 15% control across all treatments. At 21 DAT, only the treatments applied sequentially showed significant control, with effectiveness exceeding 80% against Conyza spp. In contrast, the single applications of the herbicide combinations with 2,4-D were ineffective for post-emergence control of Conyza spp. 2,4Dtolerant 24Dtolerant Dtolerant 2,4 D tolerant 2 4 ENLIST® ENLIST (ENLIST® Therefore (a postemergent post emergent spp b (b crop 1 replications 2,4D 24D glyphosate chlorimuronethyl, chlorimuronethyl chlorimuron ethyl, ethyl chlorimuron-ethyl cloransulammethyl, cloransulammethyl cloransulam methyl, methyl cloransulam-methyl imazethapyr bentazon imazamox DAT (DAT glufosinateammonium glufosinate ammonium 80 contrast postemergence emergence 4Dtolerant 24 2, (ENLIST 4D 8

RESUMO Objetivo: Descrever como aplicativos de smartphone podem contribuir para o gerenciamento de quadros de epilepsia em crianças e adolescentes. Fontes de dados: Trata-se de uma revisão integrativa realizada nas bases de dados Medline; PubMed e SciELO, com base nos descritores “epilepsy” e “smartphone”. Foram incluídos estudos originais publicados entre 2017–2023 em português ou inglês que respondessem à pergunta de investigação. Teses e dissertações, estudos duplicados, revisões de literatura e estudos que não responderam à questão de pesquisa foram excluídos. Síntese dos dados: Foram localizados 178 estudos, dos quais seis foram selecionados para compor esta revisão. A amostra incluiu 731 participantes (631 infantojuvenis com epilepsia e 100 cuidadores). Os aplicativos permitem a coleta da frequência de convulsões; momento e o tipo de crise; lembretes para a administração de medicamentos; e informações sobre a qualidade do sono, sendo capazes de armazenar esses dados para profissionais da saúde, cuidadores e usuários acompanharem a evolução do quadro. Conclusões: O uso de aplicativos no manejo das convulsões de crianças e adolescentes com epilepsia apresenta resultados promissores ao promoverem um monitoramento contínuo e personalizado. Novos estudos são necessários para otimizar os resultados benéficos e superar desafios. Objetivo Tratase Trata se Medline SciELO epilepsy “epilepsy smartphone. . “smartphone” 20172023 2017 2023 2017–202 investigação dissertações duplicados excluídos 17 73 631 (63 10 cuidadores. cuidadores) crise medicamentos sono saúde quadro Conclusões personalizado desafios “smartphone 2017202 201 202 2017–20 1 7 63 (6 201720 20 2017–2 6 ( 20172 2 2017–

ABSTRACT Objective: To describe how smartphone applications can contribute to the management of epilepsy in children and adolescents. Data source: This is an integrative review conducted on the Medline, PubMed, and SciELO databases, based on the descriptors “epilepsy” and “smartphone.” Original studies published between 2017–2023 in Portuguese or English that addressed the research question were included. Theses and dissertations, duplicate studies, literature reviews, and studies that did not answer the research question were excluded. Data synthesis: A total of 178 studies were located, of which six were selected for this review. The sample included 731 participants (631 children and adolescents with epilepsy and 100 caregivers). The applications allow for the collection of seizure frequency; timing and type of crisis; reminders for medication administration; and information about sleep quality. They can store these data for healthcare professionals, caregivers, and users to monitor the progress of the condition. Conclusions: The use of applications in managing seizures in children and adolescents with epilepsy shows promising results by promoting continuous and personalized monitoring. Further studies are needed to optimize beneficial outcomes and overcome challenges. Objective source Medline PubMed databases “epilepsy smartphone. “smartphone. 20172023 2017 2023 2017–202 dissertations reviews excluded synthesis 17 located 73 631 (63 10 caregivers. caregivers . caregivers) frequency crisis administration quality professionals condition Conclusions monitoring challenges “smartphone 2017202 201 202 2017–20 1 7 63 (6 201720 20 2017–2 6 ( 20172 2 2017–