Abstract In the presence of the left ventricle hypertrophy (LVH), the differential diagnosis with hypertrophic cardiomyopathy (HCM) or some phenocopy must be always considered, which can be easily suspected when the hypertrophy is markedly asymmetric. However, when the hypertrophy is homogeneous, especially if the patient has concomitant hypertension, it may be a challenge to distinguish between hypertensive and HCM, although some clinical features may help us to suspect it. In addition, patients with HCM may present with exertional angina due to microcirculation involvement in the setting of the hypertrophy itself or dynamic obstruction in the left ventricular outflow tract, but in some cases, the presence of concomitant coronary artery disease must be suspected as the cause of angina, especially if the patient has an intermediate or high-risk probability of having ischemic heart disease. We present the case of a 46-year-old Afro-American man with poorly controlled hypertension who was found to have severe LVH, and who presented with symptoms of exertional angina during follow-up. We will review the clinical features that can help us in the differential diagnosis in this context.

Resumen Ante la presencia de hipertrofia del ventrículo izquierdo (HVI), siempre se debe considerar el diagnóstico diferencial con la miocardiopatía hipertrófica (MCH) o alguna fenocopia, que puede sospecharse fácilmente cuando la hipertrofia es marcadamente asimétrica. Además, los pacientes con MCH pueden presentar angina de esfuerzo debido a la afectación de la microcirculación en el contexto de la propia hipertrofia o si ésta condiciona obstrucción dinámica al tracto de salida del ventrículo izquierdo, pero en algunos casos debe sospecharse la presencia de enfermedad coronaria concomitante como causa de la angina, especialmente si el paciente tiene una probabilidad de riesgo intermedio o alto de padecer cardiopatía isquémica. Presentamos el caso de un varón de 46 años de afroamericana con hipertensión arterial mal controlada a quien se le detectó una HVI severa, y que durante el seguimiento presentó síntomas de angina de esfuerzo. Revisaremos las características clínicas que nos pueden ayudar en el diagnóstico diferencial en este contexto.

Resumo Python regius ou pítons-bola são os famosos animais de estimação exóticos por causa de sua bela cor e padrão. A píton-bola albina é um tipo de píton-bola, mas é muito difícil determinar a diferença de fenótipo entre o genótipo selvagem e heterozigoto de albino (albino het). Neste estudo, PCR e qPCR podem distinguir entre albinos selvagens e het. O tamanho do produto de PCR de albinos selvagens e het foi de 415 pb, mas a intensidade do produto de PCR de selvagens foi mais intensa do que a de albinos het. Nenhum amplicon de PCR foi encontrado em albinos e o valor de Ct de selvagens foi menor do que Ct de albinos het. A técnica de detecção molecular, especialmente PCR e qPCR, pode determinar a diferença entre albinos selvagens e het de pítons-bola. pítonsbola pítons bola padrão pítonbola píton pítonbola, bola, . het) estudo 41 pb molecular pítonsbola. bola. 4

Abstract Python regius or ball pythons are the famous exotic pets because of their beautiful color and pattern. The albino ball python is one type of ball python, but it is very difficult to determine the difference of phenotype between wildtype and heterozygous genotype of albino (het albino). In this study, PCR and qPCR can distinguish between wildtype and het albino. The PCR product size of wildtype and het albino was 415 bp, but the intensity of PCR product of wildtype was more intense than that of het albinos. No PCR amplicon was found in albinos and the Ct value of wildtype was lower than Ct of het albinos. The molecular detection technique, especially PCR and qPCR, can determine the difference between wildtype and het albinos of ball pythons. pattern . albino) study 41 bp technique 4

Abstract Introduction: Gestational diabetes (GD) is a frequent com-plication in pregnancy. There is evidence of an association between maternal hyperglycemia and the risk of obstetric and neonatal complications. The concern with early diagnosis has allowed, among others, to reduce these complications. Horta Hospital has perceived with concern, a persistent higher disease prevalence comparing to national data. The goal of this study was to characterize the population with GD followed and with delivery in the hospital in 2021. Methods: Retrospective study of pregnant women with GD followed in medical appointment and pregnant women with GD that delivered in this hospital. Data were collected from the hos-pital computer register and recorded in a database. Demogra-phic and clinical characteristics of the pregnant women were analyzed, as well as the characteristics of the babies born from these pregnancies. Results: Of all women who gave birth at hospital, 35% had a diagnosis of GD. In this group, 58% were from 30 to 39 years old. Pregnant women with GD that were followed in medical appointment, had 35% BMI of obesity, 35% overweight, and the remaining 30% had normal weight. Family history of diabetes mellitus (DM) was present in 36% of pregnant women, and 35% had GD in a previous pregnancy. Conclusion: The prevalence of GD in this institution remains higher than data from mainland Portugal, showing the importance of increased attention to these pregnant women, in order to reduce the risk of complications. Although not enough data were collected to draw conclusions about possible causes for these results disparity, it is essential to do further investigation.

Resumo Introdução: A diabetes gestacional (DG) é uma complicação frequente na gravidez. Existem evidências da associação entre a hiperglicemia materna e o risco de complicações obstétricas e neonatais. A preocupação no diagnóstico precoce, tem vindo a permitir, entre outros, diminuir essas complicações. O Hospital da Horta tem verificado, com alguma preocupação, uma prevalência desta patologia persistentemente maior do que a dos dados nacionais. O objetivo deste trabalho foi caracterizar a população com DG acompanhada e com parto no hospital em 2021. Métodos: Estudo retrospetivo das grávidas com DG seguidas em consulta e das grávidas com DG com parto neste hospital. Os dados foram recolhidos do sistema informático hospitalar, registados e gravados numa base de dados. As características demográficas e clínicas das grávidas foram analisadas, assim como as características dos bebés nascidos destas gravidezes. Resultados: Das grávidas com parto no hospital, 35% tiveram o diagnóstico de DG. Destas 58% tinham entre 30 e 39 anos. Das grávidas com DG seguidas em consulta, 35% tinham IMC de obesidade, e 35% de excesso de peso, sendo os restantes 30% normoponderais. Antecedentes familiares de diabetes mellitus (DM) estavam presentes em 36% das grávidas com DG e 35% tinham apresentado DG em gravidez anterior. Conclusão: Mantém-se a prevalência elevada de DG nesta instituição, com valores superiores aos dados de Portugal Continental, mostrando-se a importância de uma atenção redobrada para estas grávidas de modo a reduzir o risco de complicações. Embora não tenham sido recolhidos dados suficientes que permitam tirar conclusões quanto a eventuais causas para esta disparidade de resultados, é essencial investigar as mesmas.

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD. Objectives evidencebased based cognitivebehavioral cognitive behavioral (CBT obsessivecompulsive obsessive compulsive OCD . (OCD) Methods clinicians protocol 20132020 2020 2013-202 PubMed, PubMed (PubMed Cochrane Embase PsycINFO Lilacs design measures type language tools Results 4 201 Highquality High firstline first line Internetdelivered Internet delivered Conclusion (OCD 2013202 202 2013-20 20 201320 2013-2 2 20132 2013-

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed. Objectives evidencebased based obsessivecompulsive obsessive compulsive . (OCD) Methods (APA (2013 , (SSRIs) clomipramine SNRIs, SNRIs (SNRIs) glutamatemodulating glutamate modulating agents 20132020 2020 2013-202 databases study measures publication language tools ACC/AHA. ACCAHA ACC/AHA ACC AHA (ACC/AHA) Results 5 201 Highquality High firstline first line Moreover risperidone, (risperidone aripiprazole SSRIresistant SSRI resistant Conclusion 812 8 12 8-1 weeks harmful ketamine lamotrigine Nacetylcysteine, Nacetylcysteine N acetylcysteine, acetylcysteine N-acetylcysteine detailed (OCD (201 (SSRIs (SNRIs 2013202 202 2013-20 (ACC/AHA 20 81 1 8- (20 201320 2013-2 2 (2 20132 2013- (

Resumen Objetivo Analizar los casos notificados de violencia interpersonal contra mujeres en el estado de Espírito Santo. Métodos Estudio analítico, tipo transversal, en el que se analizaron los casos notificados de violencia contra la mujer en el período de 2011 a 2018 en Espírito Santo. Los datos que fueron analizados en este estudio son resultantes de las Fichas de Notificación/Investigación de Violencia Interpersonal y Autoprovocada provenientes del Sistema de Información de Agravios de Notificación (SINAN). Los análisis estadísticos se realizaron mediante la prueba χ2 de Pearson y regresión de Poisson, con el uso del software Stata 14.1, donde se consideraron significativos valores de p menores que 0,05. Resultados La notificación de violencia interpersonal en el sexo femenino representó una frecuencia de 74,9 % (n=20.449; IC95 %: 74,4-75,4). Se observó que niñas y adultas mayores presentan un 35 % más de prevalencia de este agravio, comparadas con adolescentes. Existe una mayor frecuencia de este fenómeno en personas de color negro / pardo (RP: 1,07; IC95 %:1,05-1,08), comparadas con las de color blanco. Respecto a las características del agresor, se verificó mayor prevalencia en el grupo de edad de 25 años o más (RP: 1,09; IC95 %: 1,06-1,11), de sexo masculino (RP: 3,02; IC95 %: 2,88-3,17) y con sospecha de uso de alcohol en el momento de la agresión (IC95 %: 1,05-1,08). Con relación al evento, se observa una frecuencia 1,28 veces mayor en la vía pública. Conclusión Factores sociodemográficos, de comportamiento y experiencias personales de violencia influyen para que suceda este fenómeno Santo analítico transversal 201 NotificaciónInvestigación Investigación SINAN. SINAN . (SINAN) χ Poisson 141 14 1 14.1 005 0 05 0,05 749 74 9 74, n=20.449 n20449 n 20 449 (n=20.449 IC IC9 74,475,4. 744754 74,4 75,4 4 75 74,4-75,4) 3 agravio adolescentes RP (RP 1,07 107 07 %1,051,08, 105108 1,05 1,08 , 08 %:1,05-1,08) blanco agresor 2 1,09 109 09 1,061,11, 106111 1,06 1,11 06 11 1,06-1,11) 3,02 302 02 2,883,17 288317 2,88 3,17 88 17 2,88-3,17 (IC9 1,051,08. 1,05-1,08) evento 128 28 1,2 pública sociodemográficos (SINAN 14. 00 0,0 7 n=20.44 n2044 44 (n=20.44 475 74,475,4 74475 744 754 75, 74,4-75,4 1,0 10 051 %1,051,08 10510 105 108 %:1,05-1,08 061 1,061,11 10611 106 111 1,1 1,06-1,11 3,0 30 883 2,883,1 28831 288 2,8 317 3,1 8 2,88-3,1 (IC 1,051,08 1,05-1,08 12 1, 0, n=20.4 n204 (n=20.4 47 74,475, 7447 74,4-75, %1,051,0 1051 %:1,05-1,0 1,061,1 1061 1,06-1,1 3, 2,883, 2883 2, 31 2,88-3, 1,051,0 1,05-1,0 n=20. n20 (n=20. 74,475 74,4-75 %1,051, %:1,05-1, 1,061, 1,06-1, 2,883 2,88-3 1,051, 1,05-1, n=20 n2 (n=20 74,47 74,4-7 %1,051 %:1,05-1 1,061 1,06-1 2,88- 1,051 1,05-1 n=2 (n=2 74,4- %1,05 %:1,05- 1,06- 1,05- n= (n= %1,0 %:1,05 (n %1, %:1,0 %1 %:1, %:1

Abstract Objective To analyze the reported cases of interpersonal violence against women in the state of Espírito Santo. Methods This is an analytical, cross-sectional study, which analyzed the reported cases of violence against women from 2011 to 2018 in Espírito Santo. The data that were analyzed in this study are the result of the Reporting Forms/Investigation of Interpersonal and Self-inflicted Violence from the Reporting Diseases Information System (SINAN). Statistical analyzes were performed using the chi-square test and Poisson regression, using Stata 14.1, with p-values lower than 0.05 being considered significant. Results Interpersonal violence reporting in females represented a frequency of 74.9% (n=20,449; 95%CI: 74.4-75.4). It was observed that children and older adults had a 35% higher prevalence of this condition compared to adolescents. There is a higher frequency of this phenomenon among black/brown people (PR: 1.07; 95%CI: 1.05-1.08) compared to white people. As for aggressor characteristics, there is a higher prevalence in the age group of 25 years and older (PR: 1.09; 95%CI: 1.06-1.11), male (PR: 3.02; 95%CI: 2.88-3.17) and under suspicion of alcohol consumption at the time of aggression (95%CI: 1.05-1.08). Regarding the event, there is a frequency 1.28 times higher on public thoroughfare. Conclusion Sociodemographic, behavioral factors and personal experiences of violence influence its occurrence. Santo analytical crosssectional cross sectional 201 FormsInvestigation Forms Investigation Selfinflicted Self inflicted SINAN. SINAN . (SINAN) chisquare chi square regression 141 14 1 14.1 pvalues p values 005 0 05 0.0 significant 749 74 9 74.9 n=20,449 n20449 n 20 449 (n=20,449 95%CI 95CI CI 95 74.475.4. 744754 74.4 75.4 4 75 74.4-75.4) 35 adolescents blackbrown black brown PR (PR 1.07 107 07 1.051.08 105108 1.05 1.08 08 1.05-1.08 characteristics 2 1.09 109 09 1.061.11, 106111 1.06 1.11 , 06 11 1.06-1.11) 3.02 302 3 02 2.883.17 288317 2.88 3.17 88 17 2.88-3.17 (95%CI 1.051.08. event 128 28 1.2 thoroughfare Sociodemographic occurrence (SINAN 14. 00 0. 7 74. n=20,44 n2044 44 (n=20,44 475 74.475.4 74475 744 754 75. 74.4-75.4 1.0 10 051 1.051.0 10510 105 108 1.05-1.0 061 1.061.11 10611 106 111 1.1 1.06-1.11 3.0 30 883 2.883.1 28831 288 2.8 317 3.1 8 2.88-3.1 12 1. n=20,4 n204 (n=20,4 47 74.475. 7447 74.4-75. 1.051. 1051 1.05-1. 1.061.1 1061 1.06-1.1 3. 2.883. 2883 2. 31 2.88-3. n=20, n20 (n=20, 74.475 74.4-75 1.051 1.05-1 1.061. 1.06-1. 2.883 2.88-3 n=20 n2 (n=20 74.47 74.4-7 1.05- 1.061 1.06-1 2.88- n=2 (n=2 74.4- 1.06- n= (n= (n

Resumo Objetivo Analisar os casos notificados de violência interpessoal contra as mulheres no estado do Espírito Santo. Métodos Estudo analítico, do tipo transversal, em que foram analisados os casos notificados de violência contra a mulher no período de 2011 a 2018 no Espírito Santo. Os dados que foram analisados neste estudo são resultantes das Fichas de Notificação/Investigação de Violência Interpessoal e Autoprovocada provenientes do Sistema de Informação de Agravos de Notificação (SINAN). As análises estatísticas foram realizadas por meio do teste de Qui-quadrado e regressão de Poisson, utilizando o software Stata 14.1, sendo considerados significativos valores de p menores que 0,05. Resultados A notificação de violência interpessoal no sexo feminino representou frequência de 74,9% (n=20.449; IC95%: 74,4-75,4). Foi observado que crianças e idosas apresentaram 35% mais prevalência desse agravo comparada aos adolescentes. Há maior frequência desse fenômeno entre pessoas de cor preta / parda (RP: 1,07; IC95%:1,05-1,08) comparada àquelas de cor branca. Quanto às características do agressor verifica-se maior prevalência na faixa etária de 25 anos e mais (RP: 1,09; IC95%: 1,06-1,11), do sexo masculino (RP: 3,02; IC95%: 2,88-3,17) e sob suspeita de uso de álcool no momento da agressão (IC95%: 1,05-1,08). Em relação ao evento, nota-se uma frequência 1,28 vezes maior em via pública. Conclusão Fatores sociodemográficos, comportamentais e experiências pessoais de violência influenciam a ocorrência do fenômeno. Santo analítico transversal 201 NotificaçãoInvestigação Investigação SINAN. SINAN . (SINAN) Quiquadrado Qui quadrado Poisson 141 14 1 14.1 005 0 05 0,05 749 74 9 74,9 n=20.449 n20449 n 20 449 (n=20.449 IC95% IC95 IC 74,475,4. 744754 74,4 75,4 4 75 74,4-75,4) 35 adolescentes RP (RP 1,07 107 07 IC95%1,051,08 IC95105108 1,05 1,08 08 IC95%:1,05-1,08 branca verificase verifica se 2 1,09 109 09 1,061,11, 106111 1,06 1,11 , 06 11 1,06-1,11) 3,02 302 3 02 2,883,17 288317 2,88 3,17 88 17 2,88-3,17 (IC95% 1,051,08. 105108 1,05-1,08) evento notase nota 128 28 1,2 pública sociodemográficos (SINAN 14. 00 0,0 7 74, n=20.44 n2044 44 (n=20.44 IC9 475 74,475,4 74475 744 754 75, 74,4-75,4 1,0 10 051 IC95%1,051,0 IC9510510 105 108 IC95%:1,05-1,0 061 1,061,11 10611 106 111 1,1 1,06-1,11 3,0 30 883 2,883,1 28831 288 2,8 317 3,1 8 2,88-3,1 (IC95 1,051,08 10510 1,05-1,08 12 1, 0, n=20.4 n204 (n=20.4 47 74,475, 7447 74,4-75, IC95%1,051, IC951051 IC95%:1,05-1, 1,061,1 1061 1,06-1,1 3, 2,883, 2883 2, 31 2,88-3, (IC9 1,051,0 1051 1,05-1,0 n=20. n20 (n=20. 74,475 74,4-75 IC95%1,051 IC95105 IC95%:1,05-1 1,061, 1,06-1, 2,883 2,88-3 (IC 1,051, 1,05-1, n=20 n2 (n=20 74,47 74,4-7 IC95%1,05 IC9510 IC95%:1,05- 1,061 1,06-1 2,88- 1,051 1,05-1 n=2 (n=2 74,4- IC95%1,0 IC951 IC95%:1,05 1,06- 1,05- n= (n= IC95%1, IC95%:1,0 (n IC95%1 IC95%:1, IC95%:1

Resumen A pesar de la importancia de las reservas ecológicas comunitarias, se sabe poco sobre los patrones espacio-temporales de su biodiversidad. Analizamos la dinámica espacio-temporal de los ensambles de escarabajos coprófagos en 4 ambientes (bosque tropical húmedo, vegetación riparia, bosque secundario y pastizal) en la Reserva Ecológica Comunitaria Bajlum Pakal, en Chiapas, México. Encontramos una mayor diversidad en el bosque tropical húmedo y en la vegetación riparia. En contraste, la dinámica temporal no presentó relación con la riqueza y diversidad de especies, por lo que la dinámica espacial fue más importante para explicar la diversidad de escarabajos coprófagos en todos los ambientes. Encontramos que el componente más importante de la diversidad β espacial fue β2 (entre ambientes), lo que sugiere que la heterogeneidad espacial de los ambientes modula los patrones de diversidad de escarabajos en esta reserva. Las estrategias de conservación deben considerar los cambios en la dinámica espacio-temporal de la diversidad ya que modulan la respuesta de los ensambles de especies a los cambios en el uso del suelo. Es importante mantener la existencia de reservas ecológicas comunitarias pues conservan la biodiversidad y la conectividad en los paisajes tropicales, así como la calidad de vida de sus habitantes.

Abstract Despite the relevance of community ecological reserves, little is known about changes in spatio-temporal biodiversity patterns in these reserves. Here, we analyzed the spatio-temporal dynamics of the dung beetle assemblages in 4 different environments (primary forest, riparian vegetation, secondary forest, and pasture) in the Bajlum Pakal Community Ecological Reserve, in Chiapas, Mexico. We found that the spatial dynamics showed differences among the analyzed environments, with higher diversity in the tropical rainforest and riparian vegetation. The temporal dynamics did not present a relationship with the richness and diversity of species; therefore, spatial dynamics were more important for explaining the diversity of beetles from all environments. When evaluating the spatial turnover, we found that the most important component of β diversity was β2 (between environments), which suggests that the environmental variation provided by the great spatial heterogeneity of the environments modulates the diversity patterns of beetles in this reserve. Conservation strategies must consider changes in the spatio-temporal dynamics that modulate species assemblages to determine their responses to changes in land use. It is important to maintain the existence of community ecological reserves that conserve biodiversity and connectivity in tropical landscapes, as well as the quality of life of its inhabitants.

Abstract Objective: Oral Squamous Cell Carcinoma (OSCC) is conventionally treated by surgical resection, and positive surgical margins strongly increase local recurrence and decrease survival. This study aimed to evaluate whether a Three-Dimensional Segmentation (3DS) image of OSCC confers advantage over Multiplanar Reconstruction (MPR) of OSCC using images of computed tomography scan in surgical planning of tumor resection. Methods: Twenty-six patients with locally advanced OSCC had tumor morphology and dimensions evaluated by MPR images, 3DS images, and Surgical Pathology Specimen (SPS) analyses (gold standard). OSCC resection was performed with curative intent using only MPR images. Results: OSCC morphology was more accurately assessed by 3DS than by MPR images. Similar OSCC volumes and dimensions were obtained when MPR images, 3DS images and SPS measurements were considered. Nevertheless, there was a strong correlation between the OSCC longest axis measured by 3DS and SPS analyses (ICC = 0.82; 95% CI 0.59–0.92), whereas only a moderate correlation was observed between the longest axis of OSCC measured by MPR images and SPS analyses (ICC = 0.51; 95% CI 0.09–0.78). Taking only SPS with positive margins into account, MPR images and 3DS images underestimated the tumor’s longest axis in eight out of 11 (72.7%) and 5 out of the 11 (45.5%) cases, respectively. Conclusion: Our data present preliminary evidence that 3DS model represents a useful tool for surgical planning of OSCC resection, but confirmation in a larger cohort of patients is required. Level of evidence: Laboratory study. Objective (OSCC survival ThreeDimensional Three Dimensional DS (3DS (MPR Methods Twentysix Twenty six (SPS gold standard. standard . standard) Results considered Nevertheless ICC 0.82 082 0 82 95 0.59–0.92, 059092 0.59–0.92 , 59 92 0.59–0.92) 0.51 051 51 0.09–0.78. 009078 0.09–0.78 09 78 0.09–0.78) account tumors s 1 72.7% 727 72 7 (72.7% 45.5% 455 45 (45.5% cases respectively Conclusion required 0.8 08 8 9 05909 0.59–0.9 0.5 05 00907 0.09–0.7 72.7 (72.7 45.5 4 (45.5 0. 0590 0.59–0. 0090 0.09–0. 72. (72. 45. (45. 059 0.59–0 009 0.09–0 (72 (45 0.59– 00 0.09– (7 (4 0.59 0.09 ( 0.0

Abstract: Case report: A 57-year-old man consulted for chest pain suggestive of angina. The electrocardiogram (ECG) showed a right bundle branch block (RBBB), not present in previous ECGs, with secondary abnormalities of repolarization without meeting the criteria for ischemia. Due to persistent angina despite treatment, an emergent coronary angiography was performed, which showed an acute thrombotic occlusion of the right coronary artery (RCA) with good collateral circulation (CC) from the left coronary tree, which did not present significant stenosis. After reperfusion, angina progressively disappeared, and RBBB resolved. The infarct size was smaller than expected, as well as the poor electrocardiographic expressiveness, due to the good heterocoronary CC that was observed in the infarcted territory. Conclusion: Myocardial infarction with acute occlusion of a coronary artery must be kept in mind in patients with persistent angina despite treatment, and the ECG does not show the typical abnormalities.

Resumen: Caso clínico: Paciente de 57 años que consultó por dolor torácico sugestivo de angina, con un electrocardiograma (ECG) que mostraba un bloqueo de rama derecha (BRD) no presente previamente, con las correspondientes alteraciones de la repolarización en contexto de bloqueo de rama sin cumplir criterios de isquemia. Por persistencia de angina a pesar del tratamiento se decidió realizar coronariografía emergente objetivando una oclusión trombótica aguda de la arteria coronaria derecha con buena circulación colateral (CC) heterocoronaria desde el árbol coronario izquierdo, el cual no presentaba lesiones significativas. Después de la revascularización, la angina desapareció progresivamente y se resolvió el BRD. Dada la buena CC heterocoronaria del territorio infartado, el tamaño del infarto fue menor de lo esperado y esto justificaría la escasa expresividad del ECG. Conclusión: El infarto de miocardio con oclusión aguda de una arteria coronaria debe tenerse en cuenta en pacientes con angina persistente a pesar del tratamiento y que el ECG no muestre las anomalías típicas.

Abstract In breeding for resistance to Fusarium head blight (FHB) there should be precise differentiation between QTL for resistance and those for spike architecture traits that indirectly affect disease. QTL mapping for FHB Type II resistance and spike architecture traits was carried out in a population of 80 RIL. Three QTL for FHB Type II resistance were identified respectively on chromosomes 2A, 4A and 6D, the last of which is reported here for the first time. The number of florets per spike and per spikelet was associated with FHB Type II resistance but there was not co-localization between QTL for these traits. However, QTL for number of spikelets per spike overlapped with those for FHB Type II resistance on chromosomes 2A and 6D. Spike architecture traits - notably, the number of florets per spike and per spikelet - should be considered in the design of breeding strategies to increase Type II resistance to FHB in bread wheat.

ABSTRACT This paper intends to explore the re-writing of the legend of Mocha Dick, done by Ortega and Martínez. In their work, they use comics’ narrative resources to blend the tale of the big white whale with mapuche mythology, some testimonial chronicles, and Melville’s famous novel. Through the study of diverse narrative resources from comics, it is intended to demonstrate how the text is constructed so that it gives a local revision of the legend of the whale. Hence, the aim is to show that Mocha Dick is not an adaptation but an autonomous appropriation which expands in complexity the myth that Reynolds and Melville gave birth.

RESUMEN En este trabajo se pretende explorar la reescritura de la leyenda de Mocha Dick que emprenden Martínez y Ortega sirviéndose de la narrativa gráfica para condensar el relato de la gran ballena albina con el imaginario mapuche y algunos hechos reales documentados que se detallan en el propio texto y la famosa novela de Melville. A través del estudio de diversos recursos retóricos del cómic se pretende mostrar cómo el texto se va construyendo de tal manera que saca a flote una mirada local de la leyenda de la ballena blanca, que se hace autónoma de sus referentes previos pero que no los desconoce del todo. De este modo, se verá que Mocha Dick se constituye como una ínsula más en el archipiélago de referencias a la leyenda del monstruo marino, con sus propios modos de contar la historia, sus propios recursos estilísticos y de contenido, así como también sus propios rasgos que emergen desde la narrativa visual y permiten determinar que esta obra no es una adaptación, ni una versión con variantes locales en un medio distinto al escrito, sino que se trata de un relato autónomo que aporta mayor complejidad al mito que cimentaron Reynolds y Melville en su momento.

ABSTRACT The lack of knowledge of the genetic parameters and the type of gene action results in difficulties to obtain varieties that combine agronomic and functional characteristics. The objective of this study was to determine the type of gene action associated with the contents of chlorophyll and agronomic characteristics in lettuce populations. The research was conducted at the Experimental Station of Vegetables, Monte Carmelo, Brazil. To perform the crosses and obtain the generations P1, P2, F1, F2, Bc1 and Bc2 the genotypes UFU-Albina#2, UFU-Albina#3, UFU-Lisa124#2#1, UFU-Crespa199#1#1 and UFU-Lisa217#5#2 were used as parents. The generations were evaluated for three characteristics: number of leaves, plant diameter and chlorophyll content. The parameters: genetic, phenotypic, environmental and additive variance, the dominance in F2, heritability in the broad and narrow-sense, the average degree of dominance based on averages, number of genes, the measure of the dominance deviations, additive effects and all interactions of ‘additive x additive’, ‘additive x dominant’ and ‘dominant x dominant’ type, were evaluated. Chlorophyll content was the most influenced by the environment. Plant diameter had the highest narrow-sense heritability for the cross UFU-Lisa-124#2#1 x UFU-Albina#3 (82.1%). The number of genes for the number of leaves varied from inconclusive to a minimum of 9 genes. The gene interactions for number of leaves were of overdominance type, while for plant diameter and for chlorophyll content the gene interactions were of partial dominance. The characteristics are suggested as being of polygenic or oligogenic nature. populations Vegetables Carmelo Brazil P1 P P2 F1 F F2 Bc UFUAlbina#2, UFUAlbina2 UFUAlbina UFU Albina#2, Albina 2 UFU-Albina#2 UFUAlbina#3, UFUAlbina3 Albina#3, 3 UFULisa124#2#1, UFULisa12421 UFULisa Lisa124#2#1, Lisa124 1 Lisa UFU-Lisa124#2#1 UFUCrespa199#1#1 UFUCrespa19911 UFUCrespa Crespa199#1#1 Crespa199 Crespa UFU-Crespa199#1# UFULisa217#5#2 UFULisa21752 Lisa217#5#2 Lisa217 5 UFU-Lisa217#5# parents phenotypic variance narrowsense, narrowsense narrow sense, sense averages deviations additive, , additive’ dominant environment UFULisa124#2#1 124#2#1 124 UFU-Lisa-124#2# UFUAlbina#3 Albina#3 UFU-Albina# 82.1%. 821 82.1% . 82 (82.1%) nature UFUAlbina#2 Albina2 Albina#2 Albina3 UFULisa124 UFULisa1242 Lisa12421 Lisa124#2#1 Lisa12 UFU-Lisa124#2# UFUCrespa199 UFUCrespa199#1# UFUCrespa1991 Crespa19911 Crespa199#1# Crespa19 UFU-Crespa199#1 UFULisa217 UFULisa217#5# UFULisa2175 Lisa21752 Lisa217#5# Lisa21 UFU-Lisa217#5 UFULisa124#2# 12421 124#2# 12 UFU-Lisa-124#2 UFUAlbina# Albina# UFU-Albina 82.1 8 (82.1% UFULisa12 Lisa1242 Lisa124#2# Lisa1 UFU-Lisa124#2 UFUCrespa19 UFUCrespa199#1 Crespa1991 Crespa199#1 Crespa1 UFU-Crespa199# UFULisa21 UFULisa217#5 Lisa2175 Lisa217#5 Lisa2 UFU-Lisa217# UFULisa124#2 1242 124#2 UFU-Lisa-124# 82. (82.1 UFULisa1 Lisa124#2 UFU-Lisa124# UFUCrespa1 UFUCrespa199# Crespa199# UFU-Crespa199 UFULisa2 UFULisa217# Lisa217# UFU-Lisa217 UFULisa124# 124# UFU-Lisa-124 (82. Lisa124# UFU-Lisa124 UFU-Crespa19 UFU-Lisa21 UFU-Lisa-12 (82 UFU-Lisa12 UFU-Crespa1 UFU-Lisa2 UFU-Lisa-1 (8 UFU-Lisa1 UFU-Crespa UFU-Lisa UFU-Lisa- (

RESUMO O desconhecimento dos parâmetros genéticos e o tipo de ação gênica resultam em dificuldades na obtenção de variedades que combinam características agronômicas e funcionais. O objetivo deste estudo foi determinar o tipo de ação gênica envolvida com o conteúdo de clorofila e características agronômicas em populações de alface. A pesquisa foi realizada na Estação Experimental de Hortaliças, Monte Carmelo, Brasil. Para realizar os cruzamentos e obter as gerações P1, P2, F1, F2, Bc1 e Bc2, os genótipos UFU-Albina#2, UFUAlbina#3, UFU-Lisa124#2#1, UFU-Crespa199#1 e UFU-Lisa217#5#2 foram usados como parentais. As gerações foram avaliadas para três características (número de folhas, diâmetro das plantas e teor de clorofila) e analisados os seguintes parâmetros: variância genética, ambiental, fenotípica, aditiva, dominância em F2, herdabilidade no sentido amplo, herdabilidade no sentido restrito, grau médio de dominância baseado em médias, número de genes, medida dos desvios da dominância, medida dos efeitos aditivos, medida de todas interações do tipo aditiva x aditiva, aditiva x dominante e dominante x dominante. O teor de clorofila foi a característica mais influenciada pelo ambiente. O diâmetro de planta apresentou a maior herdabilidade no sentido restrito para o cruzamento UFU-Lisa-124#2#1 x UFU-Albina#3 (82,1%). O número de genes para a característica de número de folhas oscilou desde valores inconclusivos até um máximo de 9 genes. As interações gênicas para número de folhas demonstraram ser do tipo sobredominância enquanto que para diâmetro de plantas e teor de clorofila do tipo dominância parcial. Sugere-se que as características avaliadas são de natureza poligênica ou oligogênica. funcionais alface Hortaliças Carmelo Brasil P1 P P2 F1 F F2 Bc Bc2 UFUAlbina#2, UFUAlbina2 UFUAlbina UFU Albina#2, Albina 2 UFU-Albina#2 UFUAlbina3 3 UFUAlbina#3 UFULisa124#2#1, UFULisa12421 UFULisa Lisa124#2#1, Lisa124 1 Lisa UFU-Lisa124#2#1 UFUCrespa199#1 UFUCrespa1991 UFUCrespa Crespa199#1 Crespa199 Crespa UFU-Crespa199# UFULisa217#5#2 UFULisa21752 Lisa217#5#2 Lisa217 5 UFU-Lisa217#5# parentais genética ambiental fenotípica amplo médias aditivos ambiente UFULisa124#2#1 124#2#1 124 UFU-Lisa-124#2# Albina#3 UFU-Albina# 82,1%. 821 82,1% . 82 (82,1%) parcial Sugerese Sugere se oligogênica UFUAlbina#2 Albina2 Albina#2 UFUAlbina# UFULisa124 UFULisa1242 Lisa12421 Lisa124#2#1 Lisa12 UFU-Lisa124#2# UFUCrespa199 UFUCrespa199# Crespa1991 Crespa199# Crespa19 UFU-Crespa199 UFULisa217 UFULisa217#5# UFULisa2175 Lisa21752 Lisa217#5# Lisa21 UFU-Lisa217#5 UFULisa124#2# 12421 124#2# 12 UFU-Lisa-124#2 Albina3 Albina# UFU-Albina 82,1 8 (82,1% UFULisa12 Lisa1242 Lisa124#2# Lisa1 UFU-Lisa124#2 UFUCrespa19 Crespa1 UFU-Crespa19 UFULisa21 UFULisa217#5 Lisa2175 Lisa217#5 Lisa2 UFU-Lisa217# UFULisa124#2 1242 124#2 UFU-Lisa-124# 82, (82,1 UFULisa1 Lisa124#2 UFU-Lisa124# UFUCrespa1 UFU-Crespa1 UFULisa2 UFULisa217# Lisa217# UFU-Lisa217 UFULisa124# 124# UFU-Lisa-124 (82, Lisa124# UFU-Lisa124 UFU-Crespa UFU-Lisa21 UFU-Lisa-12 (82 UFU-Lisa12 UFU-Lisa2 UFU-Lisa-1 (8 UFU-Lisa1 UFU-Lisa UFU-Lisa- (