Caffeine (CAF) and nicotine (NIC) are emerging contaminants and are among the most consumed substances in the world, making it crucial to monitor these contaminants. In this work, an alternative electrolyte, 2-hydroxyethylammonium acetate (2HEAA) was used for the development of an electroanalytical method for determination and quantification of CAF and NIC, simultaneously, using differential pulse voltammetry (DPV). The system with the 2HEAA electrolyte was characterized by cyclic voltammetry and electrochemical impedance spectroscopy, and the DPV parameters were optimized for the best conditions. The method was validated from a calibration curve obtained which showed limit of detection (LOD) of 0.82 and 6.26 μmol L 1 and limit of quantification (LOQ) of 2.73 and 20.8 μmol L-1 for CAF and NIC, respectively. In the precision analyses, values lower than 10% of relative standard deviation were obtained. In the presence of concomitant inorganic and organic species, the system proved to be selective in the determination of analytes. The method was used to determine the analytes in fortified samples (river water, synthetic urine and commercial milk), obtaining recoveries between 87.25 and 111.40%. The 2HEAA demonstrated high efficiency as an alternative electrolyte with good signal-to-noise ratio, increased analytical sensitivity of the method, in addition to presenting low cost and fast electrolyte preparation. (CAF NIC (NIC world work 2hydroxyethylammonium hydroxyethylammonium 2 HEAA (2HEAA simultaneously DPV. . (DPV) spectroscopy conditions LOD (LOD 082 0 82 0.8 626 6 26 6.2 LOQ (LOQ 273 73 2.7 208 20 8 20. L1 L- respectively analyses 10 species river water milk, milk , milk) 8725 87 25 87.2 11140 111 40 111.40% signaltonoise signal noise ratio preparation (DPV 08 0. 62 6. 27 7 2. 872 87. 1114 11 4 111.40 111.4 111.

RESUMEN La obsesión moderna por la seguridad (desde el miedo extremo a los gérmenes hasta la xenofobia) termina en el aislamiento. En este artículo exploramos qué hay detrás de esta preocupación por la seguridad, las metáforas que la rodean (y que provienen de la inmunología) y una forma de escapar del miedo tomando como punto de partida la idea deleuziana de la ética nómada. Desde una perspectiva contemporánea de cómo funcionan los sistemas inmunológicos, repensamos las metáforas: en la medida en que surgen nuevas caracterizaciones de la inmunidad, existe la necesidad de aproximarnos a las respuestas no defensivas, no reactivas a las demandas del devenir. Implica repensar la alteridad, la necesidad de abrazarla en lugar de evitarla, y su importancia para entender lo que nos hace humanos. Argumentaremos que la ética nómada requiere una epistemología nómada, un reconocimiento de que una comprensión y un control plenos de la realidad pueden estar fuera de nuestro alcance y, por lo tanto, una aceptación de formas de conocimiento parciales, tentativas y diversas.

ABSTRACT The modern obsession with safety (which ranges from extreme fear of germs to xenophobia) ends in isolation. In this paper, we explore what is behind of this concern with safety, the metaphors that surround it (which come from immunology), and a way to escape from fear using the Deleuzian idea of nomadic ethics as a point of departure. From a contemporary perspective of how immune systems work, we rethink the metaphors used to describe it: as far as new characterizations of immunity arise, there is a need to approach a notion of non-defensive, non-reactive answers to the ever-changing demands of a world in motion, of becoming. It implies rethinking alterity, the need to embrace it instead of avoiding it, and the need to understand its importance, the way in which it makes us humans. We will argue that nomadic ethics require a nomadic epistemology, an acknowledgement that a full understanding and control of reality may be beyond our reach, and therefore an acceptance of partial, tentative, and diverse forms of knowledge.

Resumen A través de la aplicación del concepto de subjetivación política a una investigación cualitativa, en este artículo se analizan las modalidades de participación y de apatía política en el colectivo de migrantes de origen colombiano que residen en Roma. En ambas se involucran los contextos de origen y destino donde contribuyen diversas relaciones microsociales, además del vínculo clásico ciudadano-Estado. Además, se concluye que la apatía, más que una deformación del sistema político, es un modo-estrategia a través del cual las personas entienden su mundo y se ocupan de él.

Abstract Through the application of the concept of political subjectivation to qualitative research, this article analyzes the modalities of political participation or apathy among Colombian migrants living in Rome. Both manners involve the contexts of origin and destination, where different micro-social relationships play a part, in addition to the classic citizen-State link. Furthermore, it is addressed how apathy, rather than a distorted way of approaching the political system, is a strategy through which people understand and deal with their world.

Resumen En este artículo se indagan las desigualdades en los itinerarios internacionales de entradas y salidas en el sistema universitario vinculando las migraciones con la educación y las movilidades académicas. A partir de un análisis cuantitativo de fuentes primarias y secundarias, se explora la presencia de estudiantes migrantes y de intercambio de grado y posgrado en la Universidad Nacional de Córdoba (UNC), así como las movilidades desde esta institución hacia diversos destinos del mundo. Entre los principales hallazgos destaca la identificación de espacios relativamente jerarquizados y un perfil selectivo de estudiantes en las movilidades que se encuadran en las políticas de internacionalización. Sobresale una mayor heterogeneidad de perfiles entre estudiantes de la UNC nacidos en el extranjero. El principal aporte del artículo es que se analizan simultáneamente movilidades que suelen observarse por separado, lo que permite vislumbrar los diversos recorridos de los estudiantes signados por el origen de la clase social.

ABSTRACT This paper researches the inequalities in the international itineraries of entrances and exits in the university system, linking migrations with education and academic mobility. With this purpose, it is explored from a quantitative analysis of primary and secondary sources, the presence of migrant students and undergraduate and graduate exchange students at the Universidad Nacional de Córdoba (UNC), and the mobilities from the same institution to various destinations in the world. Among the main findings, the identification of relatively hierarchical spaces and a selective profile of students in the mobilities that fall within the internationalization policies stand out. Meanwhile, among UNC students born abroad, a greater heterogeneity of profiles stands out. The main contribution of this article is to simultaneously analyze mobilities that are usually observed separately, allowing us to glimpse various routes of mobile students, marked by their social class origin.

Summary: The tomato (Solanum lycopersicum L.), due to its high demand and production, is the most important vegetable in the world, coupled with this, it is a functional food due to its antioxidant content. This crop is produced under a protected system with a synthetic inorganic fertilization source, which increases production costs. It is important to find an alternative source of fertilization and agronomic management that increases yields and improves the commercial and nutraceutical quality of this crop. The aim of the study was to verify the effect on the commercial quality and bioactive compounds of tomato, with doses of solarized bovine manure and the number of stems under a protected system, as well as evaluate the effect of organic fertilization on the soil. The research was carried out during the spring-summer 2021 cycle. Eight treatments (4×2 factorial) were obtained from the combination of four fertilization doses (0, 40, 60 Mg ha-1 of solarized manure and chemical fertilizer [Urea (46-0-0) and MAP (11-52-0)] with two numbers of stems (one and two stems) per plant. The commercial quality was superior organoleptically with the treatment of 60 Mg ha-1 and with a single stem being higher than 4.8 °Brix. The highest yield was obtained with the dose of 60 Mg ha-1 of bovine manure being statistically similar to chemical fertilization. The content of bioactive compounds (lycopene and antioxidant capacity) increased by 36% with the effect of the interaction of 60 Mg ha-1 of manure and a stem compared to the chemical treatment. The content of MO, NO3 -, NH4 + and PO4 -3 in the soil increased with the doses of manure, which reflects one of the benefits of using this fertilizer organic.

Resumen: El tomate (Solanum lycopersicum L.) por su alta demanda y producción es la hortaliza más importante en el mundo aunado a esto es un alimento funcional por su contenido de antioxidantes. Este cultivo se produce bajo un sistema protegido con una fuente de fertilización inorgánica sintética, lo cual incrementa los costos de producción. Es importante encontrar una fuente alternativa de fertilización y un manejo agronómico que incremente los rendimientos, mejore la calidad comercial y nutraceútica de este cultivo. El objetivo del estudio fue comprobar el efecto sobre la calidad comercial y los compuestos bioactivos de tomate, con dosis de estiércol bovino solarizado y el número de tallos bajo un sistema protegido, así como evaluar el efecto de la fertilización orgánica en el suelo. La investigación se desarrolló durante el ciclo primavera-verano 2021. Se obtuvieron ocho tratamientos (factorial 4×2) originados de la combinación de cuatro dosis de fertilización (0, 40, 60 Mg ha-1 de estiércol solarizado y fertilizante químico [Urea (46-0-0) y MAP (11-52-0)] con dos números de tallos (uno y dos tallos) por planta. La calidad comercial fue superior organolépticamente con el tratamiento de 60 Mg ha-1 y con un solo tallo encontrándose superior a los 4.8 °Brix. El mayor rendimiento se obtuvo con la dosis de 60 Mg ha-1 de estiércol bovino siendo estadísticamente similar a la fertilización química. El contenido de compuestos bioactivos (licopeno y la capacidad antioxidante) se incrementó un 36% con el efecto de la interacción de 60 Mg ha-1 de estiércol y un tallo en comparación con el tratamiento químico. El contenido de MO, NO3 -, NH4 +y PO4 -3 en el suelo se incrementó con las dosis de estiércol, por lo que se ve reflejado uno de los beneficios del uso de este abono orgánico.

Abstract Silence is not a phenomenon that we can place outside of language or some system of signification. Unlike mutism, which is only a negation of noise, this work explores an interpretation of silence as a frontier of meaningfulness. The word discourses on silence as a horizon of meaning sprouting as negativity to any system of signification. Considering some aspects of Bernard Dauenhauer’s work, a first moment will address the silence that occurs between words marking the discontinuities of discourse and as another possibility of discourse. Secondly, silence is understood as a border phenomenon in the background of the nameable that is not reduced to any particular type of expression of language, but as pure otherness. Finally, silence is not only in the in-between of words nor in their background, but also in the unspeakable or unnamable in the way language itself refers to things in the world. In this sense, the distinctions between ‘language’ and ‘speech’ in Heidegger as between ‘saying’ and ‘showing’ in Wittgenstein account for the ineffable ground of meaningfulness. The word is silent, finds a blind spot, with respect to itself and its representational nature.

Resumen El silencio no es un fenómeno que podamos colocar fuera del lenguaje o sistema de significación. A diferencia del mutismo que es solo una negación del ruido, este trabajo explora una interpretación del silencio como frontera de la significación. La palabra discurre sobre el silencio como un horizonte de sentido brotando como negatividad a todo sistema de significación. Considerando algunos aspectos del trabajo Bernard Dauenhauer, un primer momento abordará el silencio que ocurre entre las palabras marcando las discontinuidades del discurso y como una posibilidad más del discurso. En segundo lugar, el silencio es entendido como fenómeno fronterizo en el trasfondo de lo nombrable que no se reduce ningún tipo de expresión particular del lenguaje, sino como pura alteridad. Finalmente, el silencio no recae únicamente en el entre de las palabras ni tampoco en su trasfondo, sino que también en lo indecible o innombrable que hay en la forma que el propio lenguaje refiere a las cosas en el mundo. En este sentido, las distinciones entre ‘lenguaje’ y ‘habla’ en Heidegger como entre ‘decir’ y ‘mostrar’ en Wittgenstein dan cuenta del fundamento inefable de la significatividad. La palabra guarda silencio, encuentra un punto ciego, respecto de ella misma y su naturaleza representacional.

RESUMEN El objetivo de este trabajo consiste en valorar críticamente el modo en que se emplean los términos clave que describen el contenido conceptual y la práctica legislativa de la participación de los trabajadores en la dirección en las organizaciones estatales cubanas, y que aparecen en las principales disposiciones normativas que conforman el derecho de trabajo, el sistema legal empresarial y los documentos programáticos que contienen las estrategias socioeconómicas en Cuba, en su proyección hasta el 2030. Se realizó un estudio observacional descriptivo transversal a partir de procedimientos bibliométricos y el análisis comparativo de los principales documentos regulatorios y normativos enunciados anteriormente. Se evidenció que existe un amplio, multifacético, contextualizado y diferenciado tratamiento de los principales aspectos teóricos, que conforman el «deber ser» de la participación de los trabajadores en la dirección de las organizaciones estatales cubanas. El estudio bibliométrico y análisis comparativo de los textos utilizados permitió constatar que, a pesar de las diferencias económicas, sociopolíticas e ideológicas que existen, se observa cierta coincidencia en el tratamiento del término clave «participación de los trabajadores» que propone el sistema legal y normativo cubano y aquel que plantea la bibliografía especializada a nivel mundial sobre el tema.

ABSTRACT This paper’s purpose is to assess critically the use of key terms operated to describe the conceptual content and normative practice in Cuba’s state organization management of worker’s participation, which appear in main regulatory documents that form labor law regulations. Also in Enterprise’ legal system and programmatic documents that contain the socioeconomic strategies in Cuba in their projection until 2030. It was performed a cross-sectional, descriptive observational study based on bibliometric and comparative analysis of the main regulatory and normative documents stated above. It was evident that there is a broad, multifaceted, contextualized and differentiated treatment of the main theoretical aspects that make up the «duty» of workers' participation in Cuban state organizations management. The comparative analysis allowed stating the fact that besides of the economic, sociopolitical and ideological differences, there is a certain match on the «worker’s participation» keyword treatment provided by the legal and normative Cuban system and the specialized world-level bibliography that studies the subject.

Abstract The Europeans of the Middle Ages have always valued bread within their food system, especially as meat, another highly valued food, became scarcer. But by tradition, more than a thousand years old, in Europe and the Mediterranean, bread was the food par excellence, the only one that the faithful asked God for in their prayers because it was the one whose lack meant hunger. Grain was grown everywhere, but this didn't stop times of scarcity and famine, both in the countryside and in the cities. While the latter had other means of responding to these crises and these phenomena have been better studied there, we barely know how rural people reacted to such adversities. The response of the rural world to the cereal crisis of 1438-1440 is analyzed through a book containing the accounts of the monastery of Alcobaça for the years 1437-1440. This is clearer for the monastery, since the peasants' reactions are more difficult to discern, as they are filtered through the eyes of the landlord. In 1439, the reduction of two-thirds in the abbey's cereal revenues was countered by the cultivation of target maize, a spring cereal that could replace wheat and barley. But the crisis had other effects, such as spiraling grain prices, rising flour extraction rates and a decline in the quality of daily bread, or the resort to substitute foods. From monks to peasants, everyone felt the consequences of this crisis, albeit on very different scales and in very dissimilar ways.

Resumo Os europeus da Idade Média sempre valorizaram o pão dentro do seu sistema alimentar, sobretudo à medida que a carne, outro alimento altamente valorizado, se ia tornando mais escassa. Mas, por tradição mais que milenar, na Europa e no Mediterrâneo, o pão era o alimento por excelência, o único que os fiéis pediam a Deus nas suas orações por ser aquele cuja falta era sinónimo da fome. O cereal cultivava-se por toda a parte, sem que isso impedisse as épocas de escassez e de carestia, tanto no campo, como nas cidades. Se estas últimas tinham outros meios para responder a essas crises e estes fenómenos foram aí mais estudados, mal se conhece o modo como os homens dos campos reagiam a tais adversidades. A partir de um livro com a contabilidade do mosteiro de Alcobaça dos anos de 1437-1440, analisa-se a resposta do mundo rural à crise cerealífera de 1438-1440. Mais clara no que respeita ao mosteiro, já que as reacções dos camponeses são mais difíceis de sondar, por estarem filtradas pelo olhar do senhorio. Em 1439, a redução em dois terços das receitas de cereal da abadia foi compensada pelo cultivo do milho-alvo, um cereal de primavera que podia substituir o trigo e a cevada. Mas a crise teve outros efeitos, como a espiral dos preços do cereal, o aumento das taxas de extração de farinha e a diminuição da qualidade do pão de cada dia, ou o recurso a alimentos de substituição. Dos monges aos camponeses, todos sentiram as consequências desta crise, embora em escalas e em modos muito diferentes.

RESUMEN Colombia es el noveno productor de pitahaya amarilla en el mundo y el Departamento de Boyacá es el mayor productor con 440 hectáreas plantadas. Los fitopatógenos bacterianos pueden causar pérdidas de frutos de pitahaya y bajos rendimientos al producir la pudrición blanda de los tallos. El objetivo de esta investigación fue estudiar e identificar posibles agentes de enfermedades bacterianas de la pitahaya en Boyacá, Colombia. Trece (13) fincas de la región fueron seleccionadas para la toma de 20 muestras mediante un muestreo dirigido y al azar de tejidos de tallo y frutos con síntomas de pudrición blanda en estadios iniciales de la enfermedad. Se realizó un proceso de aislamiento microbiológico, identificación bioquímica y taxonómica molecular de las bacterias aisladas. Las secuencias del gen ARNr 16s de la región V2-V5 fueron editadas mediante la eliminación de los primers, ensamblaje y obtención de la secuencia consenso de los primers 1100R-337F y 800R -518F. El análisis filogenético fue hecho por BLAST en el NCBI, por las herramientas "Classifier" y "SeqMatch", del sitio Web del RDP y se realizaron árboles filogenéticos mediante alineamiento múltiple usando el algoritmo MUSCLE y el método de distancias de Tamura Nei. Se registraron signos como ampollas y fluidos mucilaginosos, síntomas como manchas cloróticas amarillas y marrones, pudrición blanda y licuefacción, y se reportaron posibles vectores como moscas y hormigas. Veinticinco (25) morfotipos de bacterias fueron clasificados en 4 filos, 8 familias y 13 géneros. El análisis de las secuencias del gen ARNr 16S de las cepas bacterianas mostró una identidad del 98 al 100% con Enterobacter cloacae, Pectobacterium carotovora y Paenibacillus glucanolyticus, reportados en otros estudios como causantes de la pudrición blanda del tallo y fruto de pitahaya. Se reportaron nuevas especies como posibles bacterias patógenas de pitahaya: Pantoea cypripedii, Kluyvera intermedia y Klebsiella oxytoca. Los ensayos de infectividad no arrojaron resultados positivos. La microbiota identificada en los estadios de la fase necrotrofa o final de la pudrición blanda del tallo podría estar conformada por los géneros Achromobacter, Sphingobacterium, Pseudomonas, Klebsiella, Paenibacillus, Bacillus, Stenotrophomonas y Microbacterium. En la mosca Leptoglossus zonatus asociada al cultivo se identificó Pseudomonas fulva y Lysinibacillus fusiformis. Este es el primer registro oficial de un complejo de posibles bacterias fitopatógenas del orden Enterobacterales (familia Enterobacteriaceae, Erwiniaceae y Pectobacteriaceae) en síntomas por enfermedad bacteriana en cultivos colombianos de pitahaya. La identificación de las bacterias de un pato-sistema puede orientar las prácticas de control químico y biológico con el fin de incrementar el potencial productivo y de exportación de los cultivos exóticos y huérfanos de las pequeñas fincas locales.

ABSTRACT Colombia is the ninth largest producer of dragon fruit in the world and the department of Boyacá is the largest with 440 hectares planted. Bacterial phytopathogens can cause pitahaya fruit losses and low yields by producing stem soft rot. This research aimed to study and identified possible agents of bacterial diseases of pitahaya in Boyacá, Colombia. Thirteen farms in the region were selected to take 20 samples by means of a targeted and random sampling of stem and fruit tissues with soft rot symptoms in the early stages of the disease. A process of microbiological isolation, biochemical and molecular taxonomic identification of the isolated bacteria. The 16s rRNA gene sequences of the V2-V5 region were edited by removing the primers, assembling and obtaining the consensus sequence of the primers 1100R-337F and 800R -518F. The phylogenetic analysis was performed by BLAST at NCBI, using the "Classifier" and "SeqMatch" tools from the RDP website, and phylogenetic trees were created by multiple alignment using the MUSCLE algorithm and the Tamura Nei distance method was performed. Signs like blisters and mucilaginous fluids, symptoms like yellow and brown chlorotic spots, soft rot, and liquefaction were identified, and possible vectors like flies and ants were report. Twenty-five bacterial morphotypes were identified classifieds in 4 phyla, 9 families and 13 genera. The analysis of the 16S rRNA gene sequences of the bacterial strains showed a 98 to 100% identity with Enterobacter cloacae, Pectobacterium carotovora and Paenibacillus glucanolyticus, reported in other studies as causing the soft rot of the pitahaya stem and fruit. New species were reported as possible pathogenic bacteria of pitahaya: Pantoea cypripedii, Kluyvera intermedia and Klebsiella oxytoca. Infectivity assays did not have positive results. The microbiota identified in the stages of the necrotrophic phase or final stage of soft rot of the stem belong to the genera Achromobacter, Sphingobacterium, Pseudomonas, Klebsiella, Paenibacillus, Bacillus, Stenotrophomonas and Microbacterium. In the fly Leptoglossus zonatus associated with the crop were identified Pseudomonas fulva and Lysinibacillus fusiformis were identified. This is also the first official report of a complex of possible phytopathogen bacteria of the order Enterobacterales (Enterobacteriacea, Erwiniaceae and Pectobacteriaceae family) in symptoms by bacterial disease on pitahaya Colombian crops. Identification of the bacteria in a pathogenic system can guide chemical and biological control practices in order to increase the productive and export potential of exotic and orphan crops from small local farmings.

Malawi's economy heavily depends on agriculture, including both commercial and subsistence farming. Smallholder and small-medium enterprises leading the production of tomatoes in Malawi cannot satisfy local demand due to problems such as pests, diseases, unstable markets, and high costs. Many farmers lack the expertise to effectively manage these threats. To address the problem of tomato leaf disease identification, this research aimed to develop an automated system for tomato leaf disease detection by utilizing data augmentation techniques, MobileNetV3, and Convolutional Neural Network algorithms. We trained models on secondary data collected from the public PlantVillage dataset and tested the resultant classifiers on primary data of local farm images. The experimental results demonstrate that both models tested better on the PlantVillage dataset. Additionally, with an accuracy of 92.59% and a loss of 0.2805, the pre-trained MobileNetV3 model conventionally performs better than a CNN model. However, when tested on the primary field dataset, the models did not meet expectations for generalization, with the pre-trained MobileNetV3 achieving an accuracy of 9.2%, and loss of 12.91 and the CNN achieving an accuracy of 10.14% and loss of 8.11. The experiments aided in showing that the models trained on the PlantVillage dataset are not as effective when applied in real-world scenarios. Further improvements are needed to enhance the models' generalization in real-world scenarios.

Resumen En Cuba, la falta de equipos de medición, el alto costo de las estaciones de contaminación atmosférica y las limitantes para acceder a nuevas tecnologías, dificultan el monitoreo continuo de la calidad del aire. Por tales motivos, la presente investigación tuvo como objetivo, caracterizar contaminantes criterio empleando el modelo System for Integrated modeLling of Atmospheric coMposition. Se obtuvo una serie diaria de concentraciones estimadas de contaminantes criterio en La Habana durante el año 2021. Se realizó una caracterización del comportamiento de los contaminantes analizando las concentraciones medias diarias y medias mensuales. Se realizó una revisión de los días en que las concentraciones sobrepasaban los valores de las concentraciones máximas admisibles establecidas en la Norma Cubana. Además, se compararon estos resultados con los Valores Guías de Calidad del Aire recomendados por la Organización Mundial de la Salud. De forma general, los valores diarios estimados de las concentraciones de los contaminantes se correspondieron con los patrones de distribución espacial y temporal característicos observados en estudios precedentes en la ciudad con monitoreo automático y activo. Se reafirma así la utilidad de la herramienta de las salidas del modelo System for Integrated modeLling of Atmospheric coMposition para brindar información de calidad del aire en La Habana.

Abstract In Cuba, the lack of measurement equipment, the high cost of air pollution stations and the limitations to access new technologies make continuous monitoring of air quality difficult. For these reasons, the objective of this research was to characterize criterion pollutants using the System for Integrated modeling of Atmospheric coMposition model. A daily series of estimated concentrations of criteria pollutants was obtained in Havana during the year 2021. A characterization of the behavior of the pollutants was carried out by analyzing the average daily and average monthly concentrations. A review was carried out of the days in which concentrations exceeded the values of the maximum admissible concentrations established in the Cuban Standard. In addition, these results were compared with the Air Quality Guide Values recommended by the World Health Organization. In general, the estimated daily values of pollutant concentrations corresponded to the characteristic spatial and temporal distribution patterns observed in previous studies in the city with automatic and active monitoring. Thus, the usefulness of the tool of the outputs of the System for Integrated modelLing of Atmospheric coMposition model to provide air quality information in Havana is reaffirmed.

Abstract Introduction The prevalence of otitis media (OM) is substantial all over the world. Epidemiological data related to the economic burden of OM globally is minimal. The present systematic review was undertaken to estimate the economic burden of this disease in various parts of the world. Objectives An extensive literature search was done using PRISMA guidelines to identify relevant studies that estimated the economic burden of OM in monetary terms. The databases searched were PubMed Central, Ovid, and Embase. The cost estimation was done for one specific year and then compared considering the inflation rate. Data Synthesis The literature search led to the inclusion of 10 studies. The studies evaluated direct and indirect costs in monetary terms. Direct costs (health system and patient perspective) ranged from USD (United States Dollar) 122.64 (Netherlands) to USD 633.6 (USA) per episode of OM. Looking at only the patient perspective, the costs ranged from USD 19.32 (Oman) to USD 80.5 (Saudi Arabia). The total costs (direct and indirect) ranged from USD 232.7 to USD 977 (UK) per episode of OM. The economic burden per year was highest in the USA (USD 5 billion). The incidence of OM episodes was found more in children < 5 years old. Introduction of pneumococcal conjugate vaccines decreased the incidence in children and now the prevalence in adults is of concern. Conclusion The economic burden of OM is relatively high globally and addressing this public health burden is important. Approaches for the prevention, diagnosis, and treatment should be undertaken by the health system to alleviate this disease burden. (OM world minimal terms Central Ovid Embase rate 1 perspective United Dollar 12264 122 64 122.6 Netherlands (Netherlands 6336 633 6 633. (USA 1932 19 32 19.3 Oman (Oman 805 80 80. Saudi Arabia. Arabia . Arabia) 2327 232 7 232. 97 UK (UK billion. billion billion) old concern important prevention diagnosis 1226 12 122. 63 193 3 19. 8 23 9 2

In hierdie bydrae sal aangetoon word op welke wyse Hegel in die Phänomenologie des Geistes (1988; hierma FvdG (2013)) betoog dat subjek en objek nie afsonderlik van mekaar bedink kan word nie. Die antwoord op hierdie vraagstuk lê in 'n bepaalde toeëiening van die begrip van die absolute wat as dialektiese bemiddeling tussen subjek en objek dien, waaruit die begrip van selfbewussyn na vore tree. Selfbewussyn is nie alleen 'n hoër vorm van subjektiwiteit nie, maar vorm deel van die groter werklikheid van subjek en objek. Enersyds is die belangrikheid van hierdie vraagstuk van so 'n aard dat dit verdien om geïsoleerd binne Hegel se Phänomenologie bespreek te word, en andersyds moet die vraagstuk gekontekstualiseer word sodat die wyer debatte waarbinne Hegel se antwoord op hierdie aangeleentheid neerslag vind, ook die nodige aandag kry. Ten slotte moet daar ook gewys word op die posisie wat hierdie onderwerp binne Hegel se eie sisteem beklee, naamlik as oorgang tot die begrip van Anerkennung, bloot om die problematiek van denke oor die selfbewussyn as geïsoleerde onderwerp uit te wys. Die debat rondom die verhouding tussen subjek en objek sal vanaf Kant gerekonstrueer word, met die twee sleutelfigure van Fichte en Schelling as verteenwoordigers van uiteenlopende strominge waaruit Hegel geput het. Beide staan egter 'n bemiddelende, spekulatiewe toevoeging tot die subjek-objek-verhouding, die absolute, voor. By Fichte staan die absolute nader aan die subjek en by Schelling die objek, oftewel die natuur. Hegel neem elemente by beide oor maar behou die absolute as bemiddeling. In die eerste drie hoofstukke van Hegel se Fenomenologie van die Gees (FvdG) word die objektiewe aanspraak wat die wetenskap op die waarheid maak ondersoek en word dit as ontoereikend aangebied aan die hand van die inherent weersprekende begrippe (dat 'n ding tegelyk uit 'n eenheid en veelheid van kragte kan bestaan) waarvan dit noodwendig gebruik maak om wetenskap te kan wees. Hiermee wil Hegel nie die wetenskaplike metode as sodanig irrelevant verklaar nie, maar poog om die groter beweging wat die begrip van objektiewe eksterne werklikheid moontlik maak, te identifiseer en uiteindelik te inkorporeer by 'n meer omvangryke begrip van waarheid. Sodanige omvangryke begrip sal noodwendig rekening moet hou met die subjektiewe; die verstandsaktiwiteit waaruit begrippe gevorm word. Anders as by sy voorgangers (Descartes en Kant) beweer Hegel egter nie dat die subjektiwiteit die werklikheid omvat nie, vandaar sy gebruik van die begrip van die fenomenologie, wat op die gebeurtenis van die verskynsels fokus. Die ware is nie 'n afgesonderde noumenale sfeer wat nooit deur die subjek geken kan word nie, maar ontvou as dít wat ten dele deur die subjektiewe, die interpreterende selfbewus-syn, oopgemaak word. Ten slotte dra die besef van die wederkerigheid van subjek en objek by tot die totstandkoming van die selfbewussyn, 'n begrip wat wys op die verweefdheid van bestaan (syn) en self. Drie fases van die objektiewe opvatting van die werklikheid word in die proses van die totstandkoming van selfbewussyn uitgedaag: die aansprake van die sintuiglike sekerheid, die waarneming (gegrond op Hume se sogenaamde "secondary impressions") en ten laaste die begrip van krag as dit wat onderliggend aan alle liggame is. Hegel wys daarop dat die selfbewussyn nie die resultaat, of passiewe waarnemer is van die werklikheid soos dit in die wetenskap voorgestel word nie, maar dat dit 'n noodsaaklike bydrae lewer om die werklikheid van die wetenskap te postuleer sonder om die gewaarwording tot subjektiwiteit te reduseer. Die objektiewe en die subjektiewe is nie twee geskeide domeine van die werklikheid nie, maar gee gelyktydig aan mekaar oorsprong. Laastens sal daarop gewys word dat selfbewussyn nie eenduidig is nie, maar in verhouding staan tot ander selfbewussyne.

This article will explore in what sense subject and object are considered reciprocally in Hegel's first three chapters in the Phenomenology of Spirit. The third chapter, although notoriously difficult to read, is one of the most important epistemological documents in modern philosophy. Hegel's approach will be traced within the debate stemming from Kant's transcendental philosophy mainly through Fichte and Schelling. It will be shown that Hegel incorporated elements from all these figures to arrive at his unique position. Kant's transcendental philosophy established the idea that the thinking consciousness contributes fundamentally to knowledge to the extent that knowledge is fully produced by the subject, and the true nature of the object is unattainable to consciousness. The widely held conclusion was that Kant S thought amounted to a too strong divide between subject and object. Fichte and Schelling managed, thanks to the notion of the absolute, to mediate between subject and object, thereby opening the door to Hegel's dialectics as a philosophy of mediation. Both Fichte and Schelling, as was the case, broadly speaking, with German Idealism taken as a whole, still considered thinking as an activity of being that contributes to the fulfilment of being, linking objects to consciousness. Fichte's "absolute I", a consciousness that precedes the consciousness of the self, standing over the self and the object, was deemed to resemble the Kantian subject too closely. Schelling's natural philosophy, on the other hand, situates the absolute within nature and consciousness as developing from within nature towards the deployment of the self. This approach was considered potentially falling back into a dogmatic mode of thinking. Even if these positions remain caught in problems they seek to overcome, they did make notable progress in addressing the question of the relation of the subject to the object in a modern context. Hegel develops his initial answer to this question in the Phenomenology of Spirit first as an inheritor of the Enlightenment, notably empiricism, but stands critical of its basic suppositions. He does not accept that complete knowledge is immediately accessible, and resorts to the notion of the Absolute to indicate that mediated knowledge leads to truth. Unlike Fichte, Reinhold and Schelling, he does not immediately introduce the absolute as a mediator of knowledge but arrives at it through counterarguments for the positions put forward by the assumption of immediate objective knowledge. This dialectic approach leads to the unfolding of consciousness, self-consciousness and Spirit. Our subjective contribution to knowledge production is also not assumed beforehand, like in Kant, but is the result of the confrontation with the assumptions made by experiential knowledge. Without subjectivity, knowledge of the unity of reality is impossible, as is knowledge of the difference between objects. Knowing objects according to their nature requires subjectivity from which order is established, but the subject experiences itself as standing in relation to objects. Consciousness is confronted by an outside world that must be made sense of. Not only is the establishment of the relation between subject and object important but according to Hegel, the subject's relation to the object is reflected in his self-understanding and self-consciousness. The notion of self-consciousness is revealed precisely by the relation between subject and object, but not before this relation. Hegel therefore starts his journey to the absolute through natural consciousness, a consciousness that takes immediate knowledge of objects around us as authoritative. One can call this immediate knowledge objective in the sense that it takes no queues from subjectivity. Hegel proceeds to critique objective knowledge, claiming that immediate knowledge doesn't reckon with the factor of time, and therefore cannot be the ultimate source of truth. This critique is ambivalent, as it does recognise the world of objects as a source for knowledge, however, this must be supplemented by our own consciousness in order to arrive at a deeper understanding of this knowledge. Consciousness becomes an essential ingredient necessary for understanding. The second chapter introduces perception as the measure of reality. Perception brings a multitude of things under a general principle, thereby creating an understanding between things and their general substance. This second approach to truth cannot explain how generality and particularity exist in the first place. Hegel moves to the notoriously difficult third chapter in which he describes the dynamic relation between force and understanding. Force is identified as the underlying dimension of external reality, but it has in turn to be postulated, making necessary the involvement of the understanding as hypothesising activity. At first, force is merely described in terms of its expressions, but acknowledgement of its fundamental trait as underlying the whole of physical reality without being a tangible thing, leads to the realisation of the role of the understanding. This realisation is self-consciousness. Self-consciousness becomes aware of its participative role in its determination of the underlying structures of reality, structures that are postulated, and not apparent. In the last section, it is pointed out that self-consciousness is not to be understood as standing alone concerning objects - self-consciousness also stands in relation to other-selves. Self-consciousness is not an object and cannot be fully determined as is the case with things. This does not form the primary concern of the article and will merely be described to point to the position of self-consciousness within the larger scheme of Hegel's thinking. This does not take away the importance that the topic under discussion here has for the development of Hegel's system, which is the reason for the focus given here.

Abstract The global syndemic is an issue that is gaining notoriety in the world. The syndemic is understood as the interaction between obesity, malnutrition and climate change, that is, synergy of epidemics and complex situations, which coexist in time and place and their consequences for health. However, little is known about the relationship between the global syndemic and the consumption of ultra-processed foods (UPF). In this context, the present essay aims to reflect on the relationship established between the global syndemic and the consumption of UPA. Starting with obesity, it is known that excessive consumption of UPA is one of the main causes of this chronic non-communicable disease. However, there is also a direct relationship between malnutrition and the consumption of UPA, since people who are in a situation of food insecurity choose economically accessible foods, characterizing themselves as a double burden of malnutrition. While studies on sustainable diets advance, knowledge about the association between climate change and UPA consumption is still incipient. Although studies highlight its environmental impacts in the handling and consumption of meat, in addition to the use of pesticides, it may play a secondary role. In this sense, studies are needed that evaluate the consumption of UPA and its relationship with the global syndemic, to support the formulation of public policies aimed at improving the consumption of healthy and sustainable foods for the planet.

Resumen La sindemia global es un tema que está ganando notoriedad en el mundo. La sindemia se entiende como la interacción entre la obesidad, la desnutrición y el cambio climático, es decir, sinergia de epidemias y situaciones complejas, que coexisten en tiempo y lugar y sus consecuencias para la salud. Sin embargo, poco se sabe sobre la relación entre la sindemia global y el consumo de alimentos ultraprocesados (AUP). En este contexto, el presente ensayo tiene como objetivo reflexionar acerca de la relación que se establece entre la sindemia global y el consumo de AUP. Empezando por la obesidad, se sabe que el consumo excesivo de AUP es una de las principales causas de esta enfermedad crónica no transmisible. Sin embargo, también existe una relación directa entre desnutrición y el consumo de AUP, ya que las personas que se encuentran en situación de inseguridad alimentaria eligen alimentos económicamente accesibles, caracterizándose como una doble carga de malnutrición. Mientras avanzan los estudios sobre las dietas sostenibles, el conocimiento sobre la asociación entre el cambio climático y el consumo de AUP es aún incipiente. Aunque los estudios destacan sus impactos ambientales en el manejo y consumo de carne, además del uso de pesticidas, pudiendo jugar un papel secundario. En este sentido, se necesitan estudios que evalúen el consumo de AUP y su relación con la sindemia global, para apoyar la formulación de políticas públicas encaminadas a mejorar el consumo de alimentos saludables y sostenibles para el planeta.

Resumen El bienestar es un principio importante para las sociedades modernas. En su investigación es necesario que se refleje la cultura local de la población estudiada. Las redes semánticas y la teoría de grafos apoyan este fin pues la definición del bienestar se deriva directamente de la muestra de la población de interés. En la etapa uno (N = 201, 52% mujeres y 48% hombres, voluntarias[os] -con consentimiento informado-, 20 años y mayores, media = 39.97 años, D.E. = 13.56 años) se generaron redes semánticas para definir el concepto de bienestar. En la etapa dos las redes semánticas fueron el fundamento para la construcción de dos escalas que se validaron (N = 427, 55% mujeres y 45% hombres, voluntarias[os] -con consentimiento informado- 20 años y más, media = 37.75 años, D.E. = 12.54 años). Analizado con la teoría de grafos, el bienestar resultó ser un sistema social complejo (no lineal, fenómeno de mundo pequeño, emergencia), y mostró los principales elementos para definir el bienestar (componentes afectivos y cognitivos). De los subgrafos se derivaron los tres principales dominios con sus subdominios: salud (física y psicológica), relaciones significativas (familia, amigas[os], comunidad) y recursos (personales, materiales, de tiempo). La escala de satisfacción con el bienestar y la escala de experiencias de bienestar tuvieron buen ajuste mostrando valores adecuados. Las redes semánticas probaron ser un buen recurso para ayudar en la construcción de un cuestionario para estudiar el bienestar subjetivo con una perspectiva culturalmente relevante.

Abstract Studied worldwide, well-being is an important principle for the modern societies and needs to reflect the local cultures of the targeted populations. Semantic networks and graph theory address this issue: a definition of well-being comes directly from a sample of the targeted population. The stage one (N = 201, 52% female and 48% male, volunteers-informed consent provided-, 20 years and older, mean = 39.97 years, S.D. = 13.56 years) semantic networks defined well-being. In stage two the networks were the foundation to construct two scales which were validated (sample N = 427, 55% female and 45% male, volunteers-informed consent provided- 20 years and older, mean = 37.75 years, S.D. = 12.54 years). Analyzed with graph theory, well-being resulted in a social complex system (non-linearity, small world phenomenon, emergency), and showed the main elements to define well-being (affect and cognitive components). Its subgraphs were arranged into three main domains with subdomains: health (physical and psychological), relationships (family, friends, community) and resources (personal, material, time). The scale of satisfaction with well-being (α = .912) and the scale of experiences of well-being (α = .969) showed a good fit and obtained adequate values. Semantic networks proved to be a good resource to help in the construction of a questionnaire to study well-being with a cultural perspective.