The recycle and utilization of expired drugs is a challenge for many countries at present. The employment of expired drugs as green corrosion inhibitors is expected to address both drug recycling and corrosion prevention issues, with significant economic and environmental value. Herein, the individually and combination corrosion inhibition performance of expired amoxicillin (AMC) and penicillin V potassium tablets (PVP) for lowcarbon steel in 20% acetic acid solution containing 600 mg L-1 chloride ion are evaluated by electrochemistry and weight loss method. Both the AMC and PVP present the mixed-type corrosion inhibitors mainly affect the cathode process when used individually. The optimum inhibition efficiency is 61.22% (AMC) and 79.21% (PVP), which all appear in 5.0 × 10-3 mol L-1. The AMC and PVP are adsorbed on the steel surface by mixed physisorption and chemisorption, which are consistent with the Langmuir adsorption isotherm. The corrosion inhibition rate drops sharply when AMC and PVP are combined use with a close mole ratio. But a small amount of PVP significantly enhance the corrosion inhibition effect of AMC, the corrosion inhibition rate from 61.22 to 79.72%. The corrosion inhibition rate of AMC and PVP combination inhibitor decreased with the increase of temperature. issues value Herein (AMC (PVP 20 60 L1 L 1 L- method mixedtype type 6122 61 22 7921 79 21 79.21 PVP, , 50 5 0 5. 103 10 3 10- L1. 1. chemisorption isotherm ratio 61.2 7972 72 79.72% temperature 2 6 612 792 7 79.2 61. 797 79.72 79. 79.7

Bisphenol A (BPA), an endocrine disruptor used in different commercial polymers, is a persistent pollutant commonly found in effluents. Conventional wastewater treatment processes have low chemical removal efficiency and are expensive. This work evaluated BPA removal using laccase enzyme produced from white rot fungus Pleurotus ostreatus. For the enzymatic production, residues of acai berry and pineapple were used as laccase inducers. The use of natural inducers led to a high enzyme production (1139 and 1031 U mL−1 to acai and pineapple, respectively). Bisphenol A was removed to a concentration lower than LOD (limit of detection) after 4 h. The degradation mechanism of BPA occurred by oxidation of methyl to hydroxymethyl group in a propane portion, with breakdown of the aromatic ring. The developed technology brought to the scene a new green, viable methodology, using vegetable waste, adding value to these residues and bringing an alternative to the BPA treatment. BPA, , (BPA) polymers effluents expensive ostreatus 1139 (113 103 mL1 mL 1 mL− respectively. respectively . respectively) limit detection h portion ring green methodology waste (BPA 113 (11 10 11 (1 (

Resumen (Objetivo). Se evaluó el manglar de Chacarita en el Pacífico Central de Costa Rica, a través de la composición florística y las poblaciones de moluscos asociados de interés comercial, con el fin de proponer actividades de aprovechamiento sustentables en el manglar. (Metodología). Mensualmente y durante un año, se realizaron visitas al área de estudio, con el propósito de establecer una base florística de árboles de mangle y medir el almacenamiento de carbono en el lugar, además, de recolectar moluscos bivalvos para analizar el estado de las poblaciones, con base en las abundancias de organismos hallados y otras características como las longitudes y la masa de estos. En los mangles, se obtuvo el diámetro de la altura de pecho (DAP en cm), la altura (m), el índice de valor de importancia (IVI) y las reservas de carbono (Mg C·ha-1). En cuanto a los moluscos, se examinaron cuatro especies de interés comercial, evaluando la longitud (cm), la masa (g) y el índice gonadosomático. Finalmente, se realizaron valoraciones económicas de los datos obtenidos en el manglar, del turismo e información histórica de pesca para el acopio de Chacarita. (Resultados). Se hallaron cinco especies de mangles, Rhizophora mangle, Rizophora racemosa, Laguncularia racemosa, Avicennia germinans y Pelliciera rhizophorae; P. rhizophorae fue la de mayor índice de valor de importancia. Se obtuvo un almacenamiento de carbono equivalente a 78.49 Mg C·ha-1. Se contabilizaron 357 organismos, de los cuales el 18 % correspondió a Anadara similis, 37.5 % a Anadara tuberculosa, 41.46 % a Leukoma spp. y 3.08 % a Mytella guyanensis. Tomando en cuenta el valor económico de las reservas de carbono y los moluscos bivalvos presentes en los muestreos, se obtuvieron valoraciones económicas de 9812.63 USD·ha-1 y 28 USD·ha-1, respectivamente. (Conclusiones). Las bajas densidades poblacionales de moluscos, especialmente del género Anadara, hacen necesario establecer medidas de gestión que permitan recuperar las poblaciones de estos. La presente investigación propone actividades de aprovechamiento sustentables, como turismo comunitario con fines educativos y culturales.

Resumo (Objetivo). O mangue de Chacarita, no Pacífico Central da Costa Rica, foi avaliado por meio da composição florística e das populações de moluscos associados de interesse comercial, com o objetivo de propor atividades de uso sustentável no mangue. (Metodologia). Foram feitas visitas mensais à área de estudo durante um ano para estabelecer uma base florística de árvores do mangue e medir o armazenamento de carbono no local, bem como para coletar moluscos bivalves para analisar o status das populações, com base na abundância de organismos encontrados e em outras características, como comprimento e massa de tais organismos. Nos manguezais, foram obtidos o diâmetro à altura do peito (DAP em cm), a altura (m), o índice de valor de importância (IVI) e as reservas de carbono (Mg C-ha-1). No que diz respeito aos moluscos, foram examinadas quatro espécies de interesse comercial., avaliando o comprimento (cm), a massa (g) e o índice gonadossomático. Por fim, foram feitas avaliações econômicas de dados de mangue, turismo e informações históricas de pesca para a coleção Chacarita. (Resultados). Foram encontradas cinco espécies de mangue, Rhizophora mangle, Rizophora racemosa, Laguncularia racemosa, Avicennia germinans e Pelliciera rhizophorae; a P. rhizophorae apresentou o índice de valor de importância mais alto. Foi obtido um armazenamento de carbono equivalente a 78.49 Mg C-ha-1. Foram calculados um total de 357 organismos, dos quais 18% correspondeu a Anadara similis, 37.5% Anadara tuberculosa, 41.46% Leukoma spp. e 3.08% Mytella guyanensis. Levando em conta o valor econômico das reservas de carbono e dos moluscos bivalves presentes nas amostras, foram obtidas avaliações econômicas de US$ 9812.63 ha-1 e US$ 28 ha-1, respectivamente. (Conclusões). As baixas densidades populacionais de moluscos, especialmente do gênero Anadara tornam necessário o estabelecimento de medidas de manejo para permitir a recuperação dessas populações. Esta pesquisa propõe atividades de uso sustentável, como o turismo comunitário para fins educacionais e culturais.

Abstract (Objective). The floristic composition and populations of associated molluscs of commercial interest of the Chacarita mangrove forest on the Central Pacific of Costa Rica were evaluated to guide proposals for sustainable exploitation activities in the mangrove forest. (Methodology). Monthly visits to the study area were conducted for one year to establish a floristic baseline of mangrove trees and measure carbon storage. Additionally, bivalve molluscs were collected to analyze the state of their populations based on the abundances of organisms found, as well as other characteristics such as length and mass. Data regarding the mangrove trees included their diameter at breast height (DBH, cm), height (m), importance value index (IVI), and carbon reserves (Mg C·ha-1). Four mollusc species of commercial interest were analyzed, using data on their length (cm), weight (g), and gonodosomatic index. Economic evaluations were also conducted using data obtained from the mangrove forest, as well as tourism and historical fishing data for the collection of Chacarita. (Results). Five species of mangroves were identified: Rhizophora mangle, Rizophora racemosa, Laguncularia racemosa, Avice germinans, and Pelliciera rhizophorae, while P. rhizophorae had the highest importance value index. The study revealed a carbon storage equivalent to 78.49 Mg C·ha-1. A total of 357 organisms were counted, with Anadara similis accounting for 18% of the total count, followed by Anadara tuberculosa (37.5%), Leukoma spp. (41.46%), and Mytella guyanensis (3.08%). When considering the economic value of carbon stocks and the bivalve molluscs obtained from the samples, economic valuations of 9,812.63 USD·ha-1 and 28 USD·ha-1 were determined, respectively. (Conclusions). The low population densities of molluscs, particularly those belonging to the Anadara genus, necessitate the establishment of management measures to facilitate the recovery of these mollusk populations. This research proposes sustainable use activities such as community tourism for educational and cultural purposes.

Abstract Building structures made of cast-in-place reinforced concrete use timber for formwork, struts, scaffolding, safety elements, and temporary construction site structures, which characterize the underutilization of biomaterial in a function of short life cycles and low added value. This work aims to survey timber consumption for temporary purposes in high-rise buildings with reinforced concrete structures cast in loco. Secondary data obtained through a systematic and exploratory review of national and international articles on timber use, reuse, and disposal was used. For studies with primary data for vertical housing buildings, timber consumption per constructed area ranged from 0.002 to 0.054 m³/m². For studies with secondary data and high-rise buildings for different uses, wood consumption ranged from 0.002 to 0.077 m 3 /m 2 . There was variability in the results of 33 times (average), explained by the methods of quantification, applications, and reuse of the material. castinplace place formwork struts scaffolding elements value highrise high rise loco used 0002 0 002 0.00 0054 054 0.05 m³m² mm m³ m² m³/m² uses 0077 077 0.07 average, average , (average) quantification applications material 000 00 0.0 005 05 m³m m³/m 007 07 (average 0.

Resumo Estruturas de edifícios em concreto armado moldado in loco utilizam madeira para fôrmas, escoras, andaimes, elementos de segurança e estruturas provisórias de canteiro, que caracterizam a subutilização do biomaterial em uma função de curto ciclo de vida e baixo valor agregado. O objetivo deste trabalho é levantar o consumo de madeira para fins provisórios em obras verticais com estrutura em concreto armado moldado in loco. Utilizou-se dados secundários obtidos por meio de uma revisão sistemática e exploratória de artigos nacionais e internacionais sobre uso, reuso e descarte da madeira. Para estudos com dados primários de edifícios habitacionais verticais o consumo de madeira por área construída foi de 0,002 a 0,054 m³/m². Para estudos com dados secundários e edifícios verticais de outros usos, o consumo de madeira foi de 0,002 a 0,077 m³/m². Houve variabilidade dos resultados de 33 vezes (média), explicada pelos métodos de quantificação, aplicações e reuso do material. fôrmas escoras andaimes canteiro agregado Utilizouse Utilizou se uso 0002 0 002 0,00 0054 054 0,05 m³m² mm m³ m² m m³/m² usos 0077 077 0,07 3 média, média , (média) quantificação material 000 00 0,0 005 05 m³m m³/m 007 07 (média 0,

Resumen:El presente estudio analiza los principales factores que tienen influencia en el consumo de agua potable, así como los patrones de consumo horario del recurso hídrico en zonas residenciales de la parroquia El Rosario. Se aplicó un estudio de caracterización urbanística por medio de fichas técnicas y análisis estadístico que denotan 3 estratificaciones en el sector (B, C y D). Se aplicaron encuestas para conocer factores que inciden en el consumo de agua potable y se realizó el registro horario de lecturas de 219 medidores de agua durante 24 horas los 7 días de la semana. El consumo de agua potable registrado presenta incrementos que tienen dependencia a factores como el número de usuarios que disponen del servicio, tipo de residencia, unidades sanitarias en uso y otras características externas. Se obtuvieron curvas de consumo horarias para cada red de distribución y los coeficientes de variación de consumo horario máximos y mínimos. Los caudales máximos ocurren a las 13h00 con 94.76 l/h y a las 19h00 con 73.46 l/h, el coeficiente máximo de variación de consumo horario (Kh_max) es de 3.44, valor que sobrepasa lo establecido en la normativa nacional vigente CPE INEN 5 (1992); los valores de los coeficientes máximos de cada barrio se presentan mediante digitalización georreferenciada.

Abstract:This study analyzes the main factors that influence drinking water consumption, as well as the hourly water consumption patterns in residential areas of El Rosario parish. A study of urban characterization was applied by means of technical data sheets and statistical analysis that showed 3 stratifications in the sector (B, C and D). Surveys were conducted to determine the factors that affect drinking water consumption, and an hourly record was made of readings of 219 water meters 24 hours a day, 7 days a week. The consumption of drinking water recorded showed increases that depend on factors such as the number of users who have the service, type of residence, sanitary units in use and other external characteristics. Hourly consumption curves were obtained for each distribution network and the coefficients of variation of maximum and minimum hourly consumption. The maximum flows occur at 13h00 with 94.76 l/h and at 19h00 with 73.46 l/h, the maximum coefficient of variation of hourly consumption (Kh_max) is 3.44, a value that exceeds that established in the current national regulation CPE INEN 5 (1992); the values of the maximum coefficients of each neighborhood are presented through georeferenced digitalization.

Abstract Purpose: To document and analyze the experience of creation, growth and decline of a Solidarity Collaboration Network in Mexico City based on the theoretical-methodological approach of the Actor-Network Theory, in order to understand the role of the key actors, the dynamics that are experienced and the challenges and problems they face in their different stages of development. Methodological design: From a qualitative approach and through a case study, we propose the use of the translation process of the Actor-Network Theory as a theoretical-methodological guide to explore and interpret the findings. Results: The paper reveals the different maneuvers, actions and tensions that led to the construction of the emerging network and its subsequent decline. Five moments describing this process were analyzed: planning of the venture, creation, formalization, growth and decline of the network where both human and non-human actors have influence in different parts of the process. Research limitations: Are linked to the fact that the findings arise from a specific case, however, they can serve as a guide for the study of similar cases and, above all, to generate a greater understanding of the different actions that can arise in the operation of a collaborative network. Findings: The paper reveals the key role of both human and non-human actors and how they influenced both the growth and decline of the network. It also identifies new facets of the emergence and development of a Solidarity Collaborative Network as a function of the incorporation of the translation process. Methodologically, it was possible to observe the value of the Actor-Network Theory as a relevant methodological theoretical tool that can help to analyze and describe how a collaborative network is constituted and stabilized.

Resumen Objetivo: Documentar y analizar la experiencia de creación, crecimiento y declive de una Red de Colaboración Solidaria en la Ciudad de México a partir del enfoque teórico-metodológico de la Teoría del Actor-Red, con la finalidad de conocer el papel de los actores clave, las dinámicas que se viven y los retos y problemáticas a las que se enfrentan en sus diferentes etapas de desarrollo. Diseño metodológico: Desde un enfoque cualitativo y a través del estudio de caso se propone la utilización del proceso de traducción de la Teoría del Actor-Red como guía teórica-metodológica, para explorar e interpretar los hallazgos. Resultados: El trabajo revela las diferentes maniobras, acciones y tensiones que dieron lugar a la construcción de la red emergente y su posterior declive. Se analizaron cinco momentos que describen este proceso: planeación del emprendimiento, creación, formalización, crecimiento y declive de la red donde tienen influencia tanto los actores humanos como no humanos en diferentes partes del proceso. Limitaciones de la investigación: Están vinculadas al hecho de que los hallazgos surgen de un caso específico, sin embargo, estos pueden servir de guía para el estudio de casos similares y, sobre todo, para generar una mayor comprensión de las diferentes acciones que pueden surgir en el funcionamiento de una red colaborativa. Hallazgos: El trabajo revela el papel clave de los actores tanto humanos como no humanos y cómo influyeron tanto en el crecimiento como en el declive de la red. Asimismo, se identifican nuevas facetas que experimentan el surgimiento y desarrollo de una Red de Colaboración Solidaria (RCS) en función de la incorporación del proceso de traducción. Metodológicamente, se pudo observar el valor de la Teoría del Actor-Red como una herramienta teórica metodológica pertinente que puede ayudar a analizar y describir cómo se constituye y estabiliza una red de colaboración.

Abstract The use of syntactic groups (nominal, verbal, etc.) which, through their repetition, acquire an intensifying value is frequent in any type of discourse and even more so in political discourse. In the two issues analyzed in this article, such repetitions assume simultaneously, together with the most proper function, that of highlighting, several others. In the first of these, the intensifying value is added to the capacity of the syntactic group to initiate a new discursive act; this will facilitate, on the one hand, the fluency of the discourse and, on the other, greater intelligibility by making explicit, through duplication, the antecedent term. In the second issue, the intensification expressed by the reiterated fragment is combined with its condition of closing the act or statement, which greatly enhances the message. We have made use of a corpus that is formed by the speeches issued by the leaders of the four most important parties in Spain during the motion of censure of President Mariano Rajoy, on May 31 and June 1, 2018.

Resumen El empleo de grupos sintácticos (nominales, verbales, etc.) que, mediante su repetición, adquieren un valor intensificador es frecuente en cualquier tipo de discurso y con mayor fuerza en el político. En las dos cuestiones que analizamos en este artículo, tales repeticiones asumen simultáneamente, junto a la función más propia, la de relieve, otras varias. En la primera de ellas, al valor intensificador se suma la capacidad del grupo sintáctico para iniciar un nuevo acto discursivo; con ello, se va a facilitar, por un lado, la fluidez del discurso y, por otro, una mayor inteligibilidad al hacer explícito, mediante la duplicación, el término antecedente. En la segunda cuestión tratada, a la intensificación que se expresa por el fragmento reiterado, se une su condición de cierre del acto o enunciado, lo que potencia en gran manera el mensaje. Nos hemos valido de un corpus que está formado por los discursos emitidos por los líderes de los cuatro partidos más importantes en España durante la moción de censura al presidente Mariano Rajoy, el 31 de mayo y el 1 de junio de 2018.

ABSTRACT The integration of technologies in the classroom is a problematic situation, which has prevented students from incorporating digital learning. The recent COVID 19 pandemic revealed gaps in the family technological cultural capital, a relevant issue, because the family, i.e. parents and guardians, are a factor in the integration of technology in the classroom of their children in elementary school. The general objective of this doctoral research was to measure the degree of incidence of the family in the integration of technologies in the classroom. Through a quantitative methodology, the survey technique, the application of a questionnaire to parents of eighth grade students and the use of a structural equation model, it was confirmed that, within the family factor, the availability of resources is the variable with the greatest impact on digital integration in the classroom, with a regression value of 2.002; followed by the technological cultural capital, with a value of 1.443; and finally the use and technological skills, with a weight of 0.614.

RESUMEN La integración de las tecnologías en la sala de clases es una situación problemática, que ha impedido al estudiantado incorporarse a la enseñanza digital. La reciente pandemia por el COVID 19 reveló brechas del capital cultural tecnológico familiar, cuestión relevante, porque la familia, es decir, padres y apoderados, son un factor en la integración de tecnología en la sala de clases de sus hijos en enseñanza básica. El objetivo general de esta investigación fue medir el grado de incidencia de la familia en la integración de tecnologías en las aulas. A través de una metodología cuantitativa, una técnica de encuesta, la aplicación de un cuestionario a padres de estudiantes de octavo año básico y el uso de un modelo de ecuaciones estructurales, se confirmó que, dentro del factor familiar, la disponibilidad de recursos es la variable de mayor incidencia en la integración digital en el aula, con un valor de regresión de 2.002; seguida del capital cultural tecnológico, con un valor de 1.443; y finalmente el uso y competencias tecnológicas, con un peso de 0.614.

Abstract: Introduction: Nonalcoholic fatty liver disease is one of the main causes of liver disease. Cytokeratin 18 emerges as a non-invasive marker for the assessment of liver fibrosis. The objective of the work was to validate the use of cytokeratin 18 in peripheral blood in the diagnosis and evolution of patients with non-alcoholic fatty liver disease. Methodology: To validate cytokeratin 18 in the diagnosis, a case-control study was carried out. The case group was patients over 18 years of age, of both sexes, with a diagnosis of non-alcoholic fatty liver disease linked to metabolic syndrome, recruited between 2/2/2019 to 2/2/2020. The control group were blood donors. They were matched 1-1 for age and sex. Cytokeratin 18 was quantified in peripheral blood of both groups. To validate cytokeratin 18 in the evolution of patients with non-alcoholic fatty liver disease, a prospective, longitudinal study was carried out. The group of patients recruited were followed for one year under standard treatment, at the end of which cytokeratin 18 was quantified in peripheral blood. Continuous variables are expressed with the mean and standard deviation. It was analyzed with Student's t test, α error < 5%. Results: 13 patients make up the case group (12 women), 53 ± 11 years old, with BMI 35.01 ± 8.9 kg/m2. The pre-treatment cytokeratin 18 value was 1410 ± 120 IU, and the post-treatment value was 117 ± 56, p < 0.005. The control group was 13 people (12 women), 43.4 ± 8.1 years and BMI 28.10 ± 5.4 kg/m2 The cytokeratin 18 value was 193 ± 7.2 IU, p < 0.005 vs. pretreatment case group. Conclusions: Cytokeratin 18 is higher in patients with non-alcoholic fatty liver disease, being statistically significant, and decreases with treatment with statistical significance, and may become a useful marker in this group of patients.

Resumen: Introducción: La enfermedad por hígado graso no alcohólico es una de las principales causas de afección hepática. La citoqueratina 18 surge como marcador no invasivo para la valoración de fibrosis hepática. El objetivo del trabajo fue validar el uso de la citoqueratina 18 en sangre periférica en el diagnóstico y evolución de los pacientes con enfermedad por hígado graso no alcohólico. Metodología: Para validar la citoqueratina 18 en el diagnóstico se realizó un estudio de tipo caso-control. El grupo caso fueron los pacientes mayores de 18 años, de ambos sexos, con diagnóstico de enfermedad por hígado graso no alcohólico vinculado al síndrome metabólico, captados entre 2/2/2019 al 2/2/2020. El grupo control fueron personas donantes de sangre. Se parearon 1-1 por edad y sexo. Se cuantificó la citoqueratina 18 en sangre periférica de ambos grupos. Para validar la citoqueratina 18 en la evolución de los pacientes con enfermedad de hígado graso no alcohólico se realizó un trabajo prospectivo, longitudinal. El grupo de pacientes captados fueron seguidos durante un año bajo tratamiento estándar, finalizando el mismo se realizó la cuantificación de citoqueratina 18 en sangre periférica. Las variables continuas se expresan con la media y desvío estándar. Se analizó con test de t Student, error α < 5% Resultados: 13 pacientes integran el grupo caso (12 mujeres), de 53 ± 11 años, con IMC 35.01 ± 8.9 kg/m2. El valor de citoqueratina 18 pre-tratamiento fue de 1410 ± 120 UI, y el valor post-tratamiento fue de 117 ± 56, p < 0,005.El grupo control fueron 13 personas (12 mujeres), de 43,4 ± 8,1 años e IMC 28,10 ± 5,4 kg/m2 El valor de citoqueratina 18 fue de 193 ± 7.2 UI, p < 0.005 vs grupo caso pretratamiento. Conclusiones: La citoqueratina 18 es más elevada en los pacientes con enfermedad hígado graso no alcohólico, siendo estadísticamente significativa y disminuye con el tratamiento con significación estadística, pudiendo constituirse en un marcador útil en este grupo de pacientes.

Resumo: Introdução: A doença hepática gordurosa não alcoólica é uma das principais causas de doença hepática. A citoqueratina 18 surge como um marcador não invasivo para avaliação de fibrose hepática. O objetivo do trabalho foi validar o uso da citoqueratina 18 no sangue periférico no diagnóstico e evolução de pacientes com doença hepática gordurosa não alcoólica. Metodologia: Para validar a citoqueratina 18 no diagnóstico, foi realizado um estudo caso-controle. O grupo caso foi composto por pacientes maiores de 18 anos, de ambos os sexos, com diagnóstico de doença hepática gordurosa não alcoólica ligada à síndrome metabólica, recrutados entre 02/02/2019 a 02/02/2020. O grupo controle eram doadores de sangue. Eles foram comparados em 1 a 1 por idade e sexo. A citoqueratina 18 foi quantificada no sangue periférico de ambos os grupos. Para validar a citoqueratina 18 na evolução de pacientes com doença hepática gordurosa não alcoólica, foi realizado um estudo prospectivo e longitudinal. O grupo de pacientes recrutados foi acompanhado durante um ano sob tratamento padrão, ao final do qual a citoqueratina 18 foi quantificada no sangue periférico. As variáveis contínuas são expressas com média e desvio padrão. Foi analisado com teste t de Student, erro α < 5%. Resultados: Compõem o grupo caso 13 pacientes (12 mulheres), 53 ± 11 anos, com IMC 35,01 ± 8,9 kg/m2. O valor de citoqueratina 18 pré-tratamento foi de 1410 ± 120 UI e o valor pós-tratamento foi de 117 ± 56, p < 0,005. O grupo controle foi de 13 pessoas (12 mulheres), 43,4 ± 8,1 anos e IMC 28,10 ± 5,4 kg/m2 O valor da citoqueratina 18 foi de 193 ± 7,2 UI, p < 0,005 vs. grupo de casos pré-tratamento. Conclusões: A citoqueratina 18 é maior em pacientes com doença hepática gordurosa não alcoólica, sendo estatisticamente significativa, e diminui com o tratamento com significância estatística, podendo se tornar um marcador útil neste grupo de pacientes.

Resumo Introdução: Nonagenários constituem um percentual de pacientes internados em ascensão, sendo a injúria renal aguda (IRA) frequente nesses pacientes. Sendo assim, é importante analisar as características clínicas dessa população e seu impacto na mortalidade. Métodos: Estudo retrospectivo de pacientes nonagenários com IRA entre 2013 e 2022 em um hospital terciário. Apenas o último internamento foi considerado e pacientes com dados incompletos foram excluídos. Uma análise por regressão logística foi realizada para definir fatores de risco para mortalidade. Um valor de p < 0,05 foi considerado significativo. Resultados: Foram incluídos 150 pacientes com mediana de idade 93,0 anos (91,2–95,0) e sexo masculino em 42,7%. Sepse foi a causa mais comum de IRA (53,3%), seguida de desidratação/hipovolemia (17,7%) e insuficiência cardíaca (17,7%). Admissão na UTI ocorreu em 39,3% dos pacientes, ventilação mecânica em 14,7%, uso de vasopressores em 22,7% e realização de terapia renal substitutiva (TRS) em 6,7%. Óbito ocorreu em 56,7% dos pacientes. Desidratação/hipovolemia como etiologia da IRA foi associado a menor risco de mortalidade (OR 0,18; IC 95% 0,04–0,77, p = 0,020). Estágio KDIGO 3 (OR 3,15; IC 95% 1,17–8,47, p = 0,023), admissão na UTI (OR 12,27; IC 95% 3,03–49,74, p < 0,001) e oligúria (OR 5,77; IC 95% 1,98–16,85, p = 0,001) foram associados à mortalidade. Conclusão: Nonagenários com IRA apresentaram alta mortalidade e IRA KDIGO 3, oligúria e admissão na UTI foram associadas ao óbito. Introdução ascensão (IRA assim Métodos 201 202 terciário excluídos 005 0 05 0,0 significativo Resultados 15 930 93 93, 91,2–95,0 912950 91 2 95 (91,2–95,0 427 42 7 42,7% 53,3%, 533 53,3% , 53 (53,3%) desidrataçãohipovolemia desidratação hipovolemia 17,7% 177 17 (17,7% 17,7%. . 393 39 39,3 147 14 14,7% 227 22 22,7 TRS (TRS 67 6 6,7% 567 56 56,7 Desidrataçãohipovolemia Desidratação OR 0,18 018 18 004077 04 77 0,04–0,77 0,020. 0020 0,020 020 0,020) 3,15 315 117847 1 8 47 1,17–8,47 0,023, 0023 0,023 023 0,023) 12,27 1227 12 27 3034974 03 49 74 3,03–49,74 0,001 0001 001 5,77 577 5 1981685 98 16 85 1,98–16,85 Conclusão óbito 20 00 0, 9 91,2–95, 91295 (91,2–95, 4 42,7 53,3 (53,3% 17,7 (17,7 39, 14,7 22, 6,7 56, 0,1 01 00407 0,04–0,7 002 0,02 02 3,1 31 11784 1,17–8,4 12,2 122 303497 3,03–49,7 0,00 000 5,7 57 198168 1,98–16,8 91,2–95 9129 (91,2–95 42, 53, (53,3 17, (17, 14, 6, 0040 0,04–0, 1178 1,17–8, 12, 30349 3,03–49, 5, 19816 1,98–16, 91,2–9 912 (91,2–9 (53, (17 004 0,04–0 117 1,17–8 3034 3,03–49 1981 1,98–16 91,2– (91,2– (53 (1 0,04– 11 1,17– 303 3,03–4 198 1,98–1 91,2 (91,2 (5 ( 0,04 1,17 30 3,03– 19 1,98– 91, (91, 1,1 3,03 1,98 (91 1, 3,0 1,9 (9

Abstract Introduction: Nonagenarians constitute a rising percentage of inpatients, with acute kidney injury (AKI) being frequent in this population. Thus, it is important to analyze the clinical characteristics of this demographic and their impact on mortality. Methods: Retrospective study of nonagenarian patients with AKI at a tertiary hospital between 2013 and 2022. Only the latest hospital admission was considered, and patients with incomplete data were excluded. A logistic regression analysis was conducted to define risk factors for mortality. A p-value < 0.05 was considered statistically significant. Results: A total of 150 patients were included, with a median age of 93.0 years (91.2–95.0), and males accounting for 42.7% of the sample. Sepsis was the most common cause of AKI (53.3%), followed by dehydration/hypovolemia (17.7%), and heart failure (17.7%). ICU admission occurred in 39.3% of patients, mechanical ventilation in 14.7%, vasopressors use in 22.7% and renal replacement therapy (RRT) in 6.7%. Death occurred in 56.7% of patients. Dehydration/hypovolemia as an etiology of AKI was associated with a lower risk of mortality (OR 0.18; 95% CI 0.04–0.77, p = 0.020). KDIGO stage 3 (OR 3.15; 95% CI 1.17–8.47, p = 0.023), ICU admission (OR 12.27; 95% CI 3.03–49.74, p < 0.001), and oliguria (OR 5.77; 95% CI 1.98–16.85, p = 0.001) were associated with mortality. Conclusion: AKI nonagenarians had a high mortality rate, with AKI KDIGO stage 3, oliguria, and ICU admission being associated with death. Introduction inpatients (AKI population Thus Methods 201 2022 excluded pvalue value 005 0 05 0.0 significant Results 15 included 930 93 93. 91.2–95.0, 912950 91.2–95.0 , 91 2 95 (91.2–95.0) 427 42 7 42.7 sample 53.3%, 533 53.3% 53 (53.3%) dehydrationhypovolemia dehydration hypovolemia 17.7%, 177 17.7% 17 (17.7%) 17.7%. . 393 39 39.3 147 14 14.7% 227 22 22.7 RRT (RRT 67 6 6.7% 567 56 56.7 Dehydrationhypovolemia Dehydration OR 0.18 018 18 004077 04 77 0.04–0.77 0.020. 0020 0.020 020 0.020) 3.15 315 117847 1 8 47 1.17–8.47 0.023, 0023 0.023 023 0.023) 12.27 1227 12 27 3034974 03 49 74 3.03–49.74 0.001, 0001 0.001 001 5.77 577 5 1981685 98 16 85 1.98–16.85 Conclusion rate death 20 202 00 0. 9 91295 91.2–95. (91.2–95.0 4 42. 53.3 (53.3% 17.7 (17.7% 39. 14.7 22. 6.7 56. 0.1 01 00407 0.04–0.7 002 0.02 02 3.1 31 11784 1.17–8.4 12.2 122 303497 3.03–49.7 000 0.00 5.7 57 198168 1.98–16.8 9129 91.2–95 (91.2–95. 53. (53.3 17. (17.7 14. 6. 0040 0.04–0. 3. 1178 1.17–8. 12. 30349 3.03–49. 5. 19816 1.98–16. 912 91.2–9 (91.2–95 (53. (17. 004 0.04–0 117 1.17–8 3034 3.03–49 1981 1.98–16 91.2– (91.2–9 (53 (17 0.04– 11 1.17– 303 3.03–4 198 1.98–1 91.2 (91.2– (5 (1 0.04 1.17 30 3.03– 19 1.98– 91. (91.2 ( 1.1 3.03 1.98 (91. 1. 3.0 1.9 (91 (9

Resumen: El objetivo de este estudio es evaluar el efecto de la atmósfera, definida como el diseño consciente del ambiente de la tienda para crear ciertas respuestas en los compradores, en los valores de compra, la actitud hacia la compra y las emociones sobre la intención de recompra en una tienda online, basado en el modelo Estímulo-Organismo-Respuesta (S-O-R, por sus siglas en inglés). Aunque estos elementos han sido estudiados ampliamente en el contexto de tiendas físicas, artículos recientes que analizan la influencia de estos elementos en el ambiente online muestran la relevancia de estudios como este en investigaciones académicas actuales de mercadeo. Los resultados de una encuesta realizada a 306 usuarios de una tienda farmacéutica online, residentes de Venezuela y otros países de América Latina, se analizaron usando ecuaciones estructurales. Los hallazgos permiten concluir que el uso del modelo S-O-R es apropiado en la predicción del comportamiento de compra online, y confirman que el valor de compra hedónico tiene un impacto directo significativo tanto en la actitud hacia las compras como en la compra emocional. Por otra parte, el valor de compra utilitario afecta negativamente la compra emocional y el factor informático favorece la actitud hacia las compras. Por último, la actitud hacia las compras y la compra emocional predicen la intención de recompra. Se discuten las implicaciones para los especialistas en marketing.

Abstract: The objective of this study was to evaluate the effect of the online store atmosphere, shopping values, attitude toward online shopping and emotions on the repurchase intention in an online store, based on the Stimulus-Organism-Response model (S-O-R). Although these elements have been studied in the context of brick-and-mortar stores, recent articles that analyze the influence of these elements in the online environment demonstrate the relevance of this study in current marketing research. The results of an online survey conducted with 306 users of an online pharmaceutical store, which included residents of Venezuela and of other Latin American countries, were analyzed using structural equations, evaluating both the measurement model and the relationship model. The findings allow us to conclude that the use of the S-O-R model is appropriate in predicting online purchase behavior, having achieved an adequate fit, and confirm that the hedonic purchase value has a significant direct impact on both the attitude toward online shopping and the emotional purchase. On the other hand, the utilitarian purchase value negatively affects the emotional purchase and the computer factor favors the attitude toward online purchase. Finally, the attitude toward online shopping and the emotional purchase predicts the repurchase intention. Implications for marketers are discussed.

Abstract: There is evidence of the high use of the neonicotinoid insecticide thiamethoxam, in tropical crops, for its effectiveness in the control of soil and plant pests. The objective of this study was to know the residuality and concentration of thiamethoxam in the papaya agroecosystem, in the main papaya fruit producing zone in the central area of the Gulf of Mexico. It was carried out during a papaya growing cycle with watermelon rotation; the taking of samples was according to the technique established by the NOM -AA-103-1988 for leaves and for fruit the NMX -FF-041-1996 by the method of quartering in papaya and watermelon, the samples were analyzed with a HPLC-UV, the data obtained were statistically analyzed by parametric and non-parametric Kruskal-Wallis tests. The presence of thiamethoxam was found in papaya and watermelon cultivation plants, the concentrations in papaya leaves reported a maximum value of 0.29 mg/kg, while for the leaves of the watermelon rotation fruit it was 0.15 mg/kg. In papaya fruit, thiamethoxam concentrations are within a range of 0.24 to 0.32 mg/kg. The concentrations and residuality of thiamethoxam mainly exceed the maximum tolerance and residuality limits of the EFSA and FAO.

Resumen: Existe evidencia del alto uso del insecticida neonicotinoide thiamethoxam en los cultivos tropicales por su efectividad en el control de plagas del suelo y la planta. El objetivo de este estudio fue conocer la residualidad y concentración del thiamethoxam en el agroecosistema de papaya en la principal zona productora de este fruto de la zona centro del Golfo de México. Este estudio se realizó durante un ciclo de cultivo de papaya con rotación de sandía; la toma de muestras se hizo según la técnica establecida por la NOM-AA-103-1988 para hojas y para fruta la NMX-FF-041-1996 mediante el método de cuarteo en papaya y sandia. Las muestras se analizaron con un equipo HPLC-UV, y los datos obtenidos se analizaron estadísticamente mediante pruebas paramétricas y no paramétricas de Kruskal- Wallis. Se encontró la presencia de thiamethoxam en la planta del cultivo de papaya y sandía. Las concentraciones en hojas de papaya reportaron como valores más altos 0.29 mg/kg, mientras que para las hojas del fruto de rotación de la sandía fue de 0.15 mg/kg. En el fruto de papaya, las concentraciones de thiamethoxam estuvieron dentro de un rango de 0.24 a 0.32 mg/kg. Las concentraciones y residualidad del thiamethoxam superan principalmente los límites máximos de tolerancia y residualidad de la EFSA y la FAO.

Abstract: Environmental pollution from transportation has been a fundamental challenge for humanity throughout history, with conventional fuels contributing significantly to environmental degradation. This project seeks to suppress pollution and reduce noise generated by motorcycle taxis, whether for personal and/or private use. The main objective of the research work was to implement an electrolyzer in the combustion system of a motorcycle taxi to suppress environmental pollution and reduce noise. Methods included vehicle preparation, electrolyzer installation, battery adjustment, hydrogen generation, emissions measurement, safety, and data collection. As a result, the electrolyzer was implemented in the single-cylinder motorcycle taxi; The noise limit allowed at work in Peru is 85 dB, which is equivalent to 100 % noise at most; When using gasoline, a value of 76.4 dB was obtained, equivalent to 89.88 % noise, and when using hydrogen, a value of 71.7 dB was obtained, equivalent to 84.35 % noise, therefore, the total noise reduction was 4.70 dB (5.53 %) than established. The discussion highlighted that hydrogen is a clean fuel, with zero emissions and only emitting water vapor instead of polluting gases (5). The conclusion highlights the critical importance of the research, supported by the total reduction of 5.53 % of noise with this new technology and in turn external sources support that using hydrogen produced a smoother and quieter combustion; Regarding the useful life of the engine, due to the cleaner and more efficient combustion, the accumulation of waste was reduced, which benefits reducing the wear of internal components and the need for costly maintenance.

Resumen: La contaminación ambiental derivada del transporte ha sido un desafío fundamental para la humanidad a lo largo de la historia, con los combustibles convencionales contribuyendo significativamente a la degradación ambiental. Este proyecto busca suprimir la contaminación y reducir el ruido generada por mototaxis, ya sean de uso personal y/o privado. El trabajo de investigación tuvo como objetivo principal implementar un electrolizador en el sistema de combustión de un mototaxi para suprimir la contaminación ambiental y reducir el ruido. Los métodos incluyeron la preparación del vehículo, instalación del electrolizador, ajuste de la batería, generación de hidrógeno, medición de emisiones, seguridad y recolección de datos. Como resultado, se logró implementar el electrolizador en el mototaxi monocilíndrico; el límite de ruido permitido en el trabajo en el Perú es de 85 dB, que equivalen el 100 % de ruido como máximo; al utilizar gasolina se obtuvo un valor de 76.4 dB equivalentes a 89.88 % de ruido y al usar hidrógeno se obtuvo un valor de 71.7 dB siendo el 84.35 % de ruido, por lo tanto, la reducción total de ruido fue de 4.70 dB (5.53%) de lo establecido. La discusión destacó que el hidrógeno es un combustible limpio, con nulas emisiones y solo emitiendo vapor de agua en vez de gases contaminantes (5). La conclusión subraya la importancia crítica de la investigación, respaldada por la reducción total del 5.53 % de ruido con esta nueva tecnología y a su vez fuentes externas apoyan, que el utilizar hidrógeno produjo una combustión más suave y silenciosa. En cuanto a la vida útil del motor, la combustión más limpia y eficiente reduce la acumulación de residuos, lo que disminuye el desgaste de los componentes internos y la necesidad de mantenimientos costosos.

ABSTRACT The study addresses the possible contribution of AI systems to the improvement of teaching and learning in Basic School Education in Paraguay based on the analysis of AI incorporation policies in the educational systems of the region, aspects of the teaching and learning that can be innovative with the intentional incorporation of AI systems, the teaching skills necessary to operate AI systems, and the approach to teacher training in the subject of AI. As a methodology, documentary research was adopted in the tone given by Cifuentes (2011), since the intention is to interpret the institutional reports and scientific articles written in the last ten years referring to the subject, which acted as information units, consulted in accessible indexed journals to offer possible scenarios. Some relevant data is related to the experiences of use in various countries of the region and Paraguay without being able to certify its consolidation, the potential pedagogical value of this technology, the high demand for ICT skills for teachers who want to innovate with AI and the look towards teacher training focused on data science, programming and computational thinking.

RESUMEN Se aborda en el estudio la posible contribución de los sistemas de Inteligencia Artificial (IA) al mejoramiento de la enseñanza y aprendizaje en la Educación Escolar Básica en Paraguay a partir del análisis de las políticas de incorporación de IA en los sistemas educativos de la región, los aspectos de la enseñanza y aprendizaje que pueden ser innovados con la incorporación intencionada de sistemas de IA, las capacidades docentes necesarias para operar sistemas de IA y el abordaje de la capacitación docente en la temática de la IA. Como metodología se adoptó la investigación documental en la tónica que da Cifuentes (2011), pues se tiene la intención de interpretar los informes institucionales y artículos científicos escritos en los últimos diez años referentes a la temática, (que actuaron como unidades de información, consultados en revistas indexadas accesibles de manera a ofrecer escenarios posibles. Algunos datos relevantes guardan relación con las experiencias de utilización en diversos países de la región y Paraguay sin que se pueda certificar su consolidación, el importe potencial pedagógico de esta tecnología, la alta demanda de competencias TIC para los docentes que quieran innovar con IA y la mirada hacia la capacitación docente enfocada a la ciencia de los datos, la programación y el pensamiento computacional.

ABSTRACT Erectile dysfunction is observed in about 50% of men. It has been found that diabetes mellitus increases its prevalence to 19-86.3%, necessitating attention to a therapeutic strategy. Among the available treatment methods, intracavernosal injections of mesenchymal stem cells have proven to be particularly effective. Objective The purpose of study is to assess and analyse the effectiveness of their use in the treatment of erectile dysfunction in patients with diabetes mellitus. Materials and Methods The literature search was conducted using systematic methods and analysis in databases such as Web of Science, Scopus, PubMed, Elsevier, and Springer, with 41 sources included for further review. Results The study highlights microangiopathic and neuropathic links as key factors in erectile dysfunction development in diabetic patients, stemming from endothelial dysfunction and conductivity disturbances. Mesenchymal stem cell therapy from bone marrow, adipose tissue, and umbilical cord mitigates pathogenic impact through regenerative and anti-apoptotic effects. Due to this, most studies indicate high efficacy of the treatment and rapid therapeutic action through intracavernosal administration. Some studies suggest an increase in the body’s receptor sensitivity to other drugs, such as sildenafil. Conclusion From the perspective of further research on this issue, standardising the preparation of stem cells and the treatment method using a large sample size is essential to introduce such a method as an extremely promising therapy for this delicate issue in men into practical medicine. The practical value of the study lies in the systematisation of information on different sources of mesenchymal stem cells for treating erectile dysfunction. 50 1986.3%, 19863 19 86.3%, 86 3 19-86.3% strategy effective Science Scopus PubMed Elsevier Springer 4 review disturbances marrow tissue antiapoptotic anti apoptotic effects administration bodys body s drugs sildenafil medicine 5 1986 1986.3% 1 863 86.3% 8 19-86.3 198 1986.3 86.3 19-86. 1986. 86. 19-86 19-8 19-