Abstract Contrast-enhanced digital mammography (CEDM) is an emerging tool that has been increasingly implemented. It appears as an alternative to magnetic resonance imaging (MRI), using intravenous contrast to explore tumor angiogenesis. It combines conventional mammography (Mx) with post-contrast dual energy subtraction technique, resulting in increased detection of breast cancer, in a short study time and at a low cost. It is a promising method in selected cases and easy to read, being useful mainly in patients with breast cancer to detect additional lesions and determine the tumor size, that helps surgical planning, as well as in the evaluation of post-neoadjuvant chemotherapy response in the follow-up of patients treated with surgery, to address inconclusive findings in screening mammogram, or as an alternative when MRI is contraindicated. The purpose of this article is to assess the usefulness of contrasted mammography in daily practice and to determine its main indications. We review with our own cases the applications and characteristics of this method.

Resumen La mamografía contrastada (CEDM, contrast-enhanced digital mammography) es una herramienta nueva que ha ido implementándose de forma creciente. Aparece como alternativa a la resonancia magnética (RM), y al igual que esta, tiene como principio el uso de contraste endovenoso para explorar la angiogénesis tumoral. Combina la imagen de mamografía convencional (Mx) con la técnica de sustracción con energía dual poscontraste, lo que resulta en un incremento en la detección de cáncer de mama, en un tiempo corto de estudio y a un bajo costo. Es un método prometedor en casos seleccionados y de fácil lectura, siendo útil principalmente en pacientes con diagnóstico de cáncer de mama para detectar lesiones adicionales y determinar el tamaño tumoral, ayudando en la planificación quirúrgica, así como también en la evaluación de la respuesta a la neoadyuvancia. También en el seguimiento de pacientes operadas, para caracterizar lesiones dudosas en Mx y ecografía, o como alternativa ante contraindicación de la RM. El objetivo de este trabajo es valorar la utilidad de la mamografía contrastada en la práctica diaria y determinar sus principales indicaciones. Repasamos con casos propios las utilidades y características del método.

Resumo Os desafios que a escola e a pedagogia hoje exigem requerem a concepção e aplicação de uma intervenção pedagógica baseada num processo de motivação verdadeiramente personalizado, estimulante, orientador, funcional, integral e com uma nova concepção do futuro cidadão que educamos. Nesse sentido, a busca de meios para atender e solucionar as dificuldades que surgem no processo ensino-aprendizagem de escolares com deficiência intelectual é necessária e imprescindível. O presente trabalho aborda a necessidade de favorecer o processo de ensino-aprendizagem da matemática a partir do desenvolvimento de habilidades para o cálculo escrito de adição e subtração em alunos com deficiência intelectual.

Resumen Los retos que hoy exige la escuela y la pedagogía obligan a diseñar y a aplicar una intervención pedagógica basada en un proceso de motivación verdaderamente personalizado, estimulador, orientador, funcional, integral y con una nueva concepción sobre el futuro ciudadano que educamos. En esta dirección se hace necesaria e imprescindible la búsqueda de las vías para atender y solucionar las dificultades que se presentan en el proceso de enseñanza-aprendizaje de los escolares con discapacidad intelectual. El presente trabajo aborda la necesidad de favorecer el proceso de enseñanza-aprendizaje de la matemática a partir del desarrollo de habilidades para el cálculo escrito de adición y sustracción en escolares con discapacidad intelectual.

Abstract The challenges demanded nowadays by school and pedagogy require the design and application of a pedagogical intervention based on a truly personalized, stimulating, guiding, functional, comprehensive motivation process and with a new conception of the future citizens we educate. In this sense, the search for ways to attend and solve the difficulties that arise in the teaching-learning process of students with intellectual disabilities is necessary and essential. The present work addresses the need to improve the teaching-learning process of mathematics from the development of skills for the written calculation of addition and subtraction in students with intellectual disabilities.

ABSTRACT The focus of this case report is to technically describe a noninvasive diagnostic evaluation of bow Hunter's syndrome using a dynamic computed tomography angiography protocol and discuss its advantages. In addition, we aimed to exemplify the quality of the study by presenting images of a 3D-printed model generated to help plan the surgical treatment for the patient. The dynamic computed tomography angiography protocol consisted of a first image acquisition with the patient in the anatomic position of the head and neck. This was followed by a second acquisition with the head and neck rotated to the side that triggered the symptoms, with technical parameters similar to the first acquisition. The acquired images were used to print a 3D model to better depict the findings for the surgical team. The dynamic computed tomography angiography protocol developed in this study helped visualize the vertebrobasilar arterial anatomy, detect vertebral artery stenosis produced by head and neck rotation, depict the structure responsible for artery stenosis (e.g., bony structure or membranes), and study possible complications of the disease (e.g., posterior cerebral circulation infarction). Additionally, the 3D-printed model better illustrated the findings of stenosis, aiding in surgical planning. In conclusion, dynamic computed tomography angiography for the evaluation of bow Hunter's syndrome is a feasible noninvasive technique that can be used as an alternative to traditional diagnostic methods. Hunters Hunter s advantages addition 3Dprinted Dprinted printed D symptoms team anatomy rotation e.g., eg e g (e.g. membranes, membranes , membranes) infarction. infarction . infarction) Additionally planning conclusion methods e.g. (e.g e.g

Abstract Objectives: This study aimed to explore the correlation between Fibroblast Growth Factor-23 (FGF23) levels and Cerebral Infarction (CI), and to determine whether there is a significant relationship between FGF23 and the occurrence and severity of CI. Methods: The study categorized Cerebral Infarction (CI) patients into severe and mild stenosis groups based on vertebrobasilar artery stenosis, using Digital Subtraction Angiography (DSA) and Magnetic Resonance Imaging (MRI). The study compared the levels of Fibroblast Growth Factor-23 (FGF23) in the serum of CI patients and healthy controls using a t-test and evaluated the diagnostic effectiveness of serum FGF23 using a Receiver Operating Characteristic (ROC) curve. Additionally, the study analyzed the correlation between FGF23 levels and CI severity after treatment using the National Institute of Health Stroke Scale score. Results: The study found a significant increase in serum Fibroblast Growth Factor-23 (FGF23) levels in patients with Cerebral Infarction (CI) compared to healthy volunteers, (p < 0.001). A higher serum FGF23 level was observed in the severe stenosis group than in the mild stenosis group (p < 0.001). Furthermore, the study showed that a high FGF23 level at admission was significantly related to more severe symptoms of CI as indicated by the National Institute of Health Stroke Scale (NIHSS) score on the 7th day after treatment (p < 0.001). Conclusions: This study discovered a correlation between Fibroblast Growth Factor-23 (FGF23) levels, vertebroba-silar artery stenosis, and short-term prognosis in patients who had recently experienced acute Cerebral Infarction (CI). Objectives Factor23 Factor 23 Factor-2 FGF (FGF23 CI, , FGF2 Methods (CI DSA (DSA MRI. MRI . (MRI) ttest t test ROC (ROC curve Additionally Results volunteers p 0.001. 0001 0.001 0 001 0.001) Furthermore NIHSS (NIHSS th Conclusions vertebroba silar shortterm short term Factor2 2 Factor- (FGF2 (MRI 000 0.00 00 (FGF 0.0 0.

Abstract Thinking about the human nowadays requires an analysis of the epistemological and ontological legacy of modern humanism, whose founding postulates are still prevailing. The idea of the human that is being handled in each specific socio-historical framework acts as a normative ideal, determining which bodies and subjectivities fit into the coordinates of intelligibility and which remain outside. This fact requires, first of all, to reveal, uncover, show the seams on which the various forms of modern humanism have woven the narratives that legitimise and naturalise the one-dimensional and discriminatory conceptions of the human. Likewise, a kind of post-foundation attempt will be presented with the aim of showing the intellectual path that could guide the objective of generating dynamic and open conceptions of the human. In short, subtractive thinking (immanent, post-evental, material, processual, sequential, relational, affirmative, creative) will be defended as a means to immanently transcend the human. prevailing sociohistorical socio historical ideal outside all reveal uncover onedimensional one dimensional Likewise postfoundation post foundation short immanent, immanent (immanent postevental, postevental evental, evental post-evental material processual sequential relational affirmative creative

Resumo Pensar o humano hoje requer uma análise do legado epistemológico e ontológico do humanismo moderno, cujos postulados fundadores ainda são válidos atualmente. A ideia de humano que está sendo tratada em cada estrutura sócio-histórica específica atua como um ideal normativo, determinando quais corpos e subjetividades são acomodados às coordenadas de inteligibilidade e quais são deixados à margem. Esse fato requer, em primeiro lugar, revelar, desvelar, mostrar as costuras sobre as quais as várias formas de humanismo moderno teceram as narrativas que legitimam e naturalizam concepções unidimensionais e exclusivas do humano. Da mesma forma, será apresentada uma espécie de tentativa pós-fundacional com o objetivo de mostrar o caminho intelectual que poderia guiar o objetivo de gerar concepções dinâmicas e abertas do humano. Em suma, o pensamento subtrativo (imanente, pós-acontecimental, material, processual, sequencial, relacional, afirmativo, criativo) será defendido como um meio de transcender o humano imanentemente. atualmente sóciohistórica sócio histórica normativo margem lugar revelar desvelar forma pósfundacional pós fundacional suma imanente, imanente (imanente pósacontecimental, pósacontecimental acontecimental, acontecimental pós-acontecimental material processual sequencial relacional afirmativo criativo imanentemente

Resumen Pensar lo humano hoy exige un análisis del legado epistemológico y ontológico del humanismo moderno, cuyos postulados fundacionales aún siguen vigentes. La idea de lo humano que se esté manejando en cada marco socio-histórico concreto actúa a modo de ideal normativo, determinando qué cuerpos y subjetividades se acomodan a las coordenadas de la inteligibilidad y cuáles quedan al margen. Este hecho exige, en primer lugar, revelar, desvelar, mostrar las costuras sobre las que las diversas formas del humanismo moderno han tejido las narrativas que legitiman y naturalizan las concepciones unidimensionales y excluyentes de lo humano. Asimismo, se presentará una suerte de tentativa postfundacional con la voluntad de mostrar la senda intelectual que podría orientar en el objetivo de generar concepciones dinámicas y abiertas de lo humano. En definitiva, se defenderá el pensamiento sustractivo (inmanente, postacontecimental, material, procesual, secuencial, relacional, afirmativo, creativo) como medio para trascender lo humano inmanentemente. vigentes sociohistórico socio histórico normativo margen lugar revelar desvelar Asimismo definitiva inmanente, inmanente (inmanente postacontecimental material procesual secuencial relacional afirmativo creativo inmanentemente

Developing structure sense is an important part of learning algebra. We investigated learners' structure sense of algebraic expressions involving brackets. This led us to propose the constructs surface structure sense and systemic structure sense. Using a random sample of 58 Grade 10 learners scoring above 40% in a test, we coded incorrect responses for surface and systemic structure errors. The initial analysis revealed that the presence of more brackets supports surface structure sense. However, learners overgeneralised the presence of brackets to represent multiplication in situations involving subtraction. The arrangement of brackets also led to errors in the order of operations. Further analysis suggested that regular application of procedures on familiar algebraic structures may give the illusion of systemic structure sense. We recommend that the teaching of algebraic expressions must emphasise what the arrangement of an expression means before focusing on how to operate on the expression. CONTRIBUTION: The research contributes to mathematics teaching by suggesting teaching strategies to improve on learners' understanding of the role of brackets in algebraic expressions, by considering the arrangement of the components in structures

ABSTRACT Inhibitory processes - perceptual, cognitive and response inhibition - are core executive functions and domain-general processes. Training tasks have been developed in order to optimize them, and eventually generate an impact on related skills. These tasks have been tested in isolation. Thus, here a global inhibitory training program was formed (with these training tasks), and their effects on performance in mathematics were analyzed, in schoolchildren in the first years of primary school. The sample was made up of 25 students, an experimental design, with an experimental group (training), a control group, a pre-test and a post-test, was applied. The training involved the execution of tasks designed to demand perceptual, cognitive and response inhibition, over six 10-15 minute sessions. In the pre- and post-test instances, all participants were evaluated on their inhibitory capacity and mathematics performance. The main results did not show significant differences between groups in the post-test, although at the intragroup level, only the experimental group significantly changed, their performance from pre to post-test on a task that requires successive subtractions, Z = -2.69, p = .007, r = -.69, observing marginal differences in the other mathematics activities (ps > .05). Considering performance in the pre-test, relationships were found between subtraction performance and inhibitory processes (ps < .05). The scope of the pilot study and the importance of considering the size of the groups and the evaluation instruments in future work are discussed. It is suggested that, at this stage, performing subtractions may imply greater executive demand - specifically inhibitory processes.

RESUMEN Los procesos inhibitorios -inhibición perceptual, cognitiva y de la respuesta- son funciones ejecutivas principales y se las entiende como procesos de dominio general. En nuestro medio se han desarrollado tareas con el objeto de optimizarlos y, eventualmente, generar un impacto en habilidades relacionadas, que se han puesto a prueba de manera aislada. Aquí se pretende aplicarlas conjuntamente, conformando un programa global de entrenamiento inhibitorio destinado a escolares de los primeros años del nivel primario, y analizar sus efectos sobre el desempeño en matemáticas. Se trabajó con 25 estudiantes en un diseño experimental, con un grupo experimental (de entrenamiento), uno de control, un pre-test y un post-test. El entrenamiento implicó la ejecución de tareas diseñadas para demandar inhibición perceptual, cognitiva y de la respuesta, a lo largo de seis sesiones de 10-15 minutos. En las instancias pre y post-test, todos los participantes fueron evaluados en su capacidad inhibitoria y en el desempeño en matemáticas. Los principales resultados no mostraron diferencias significativas entre grupos en el post-test, aunque a nivel intragrupal, solo el grupo experimental cambió significativamente su rendimiento del pre al post-test en el desempeño en una tarea de restas sucesivas, Z = -2.69, p = .007, r = -.69, observándose diferencias marginales en las otras actividades (p > .05). Considerando el rendimiento en el pre-test, se encontraron relaciones entre el desempeño en restas y procesos inhibitorios (ps < .05). Se discute en torno al alcance del estudio piloto y la importancia de considerar en futuros trabajos el tamaño de los grupos y los instrumentos de evaluación. Se sugiere que, en esta etapa, la realización de restas puede implicar mayor demanda ejecutiva -específicamente de los procesos inhibitorios.

ABSTRACT Introducction: Spontaneous intracranial hypotension is a syndrome caused by decreased CSF volume secondary to its leakage into the extradural space Although ICHD-3 provides a high level of diagnostic specificity, manifestations may be atypical, making diagnosis challenging. The site of leakage may be undetermined in point Up to 30% of cases, although with recent refinement of imaging, this percentage has been reduced to 15-20%. Currently, management is not standardized and recommendations are based on inconclusive evidence, with variability of protocols between centres. Development. In this review, we update diagnostic and therapeutic procedures. We analyse the role of whole brain and spinal cord MRI as a first investigation and review tests aimed at determining cerebrospinal fluid leakage, such as MRI myelography, conventional CT myelography, dynamic CT myelography, and digital subtraction CT myelography, as well as 111-Indium-DPTA cisternography. Determining optimal use of these investigations remains a matter of debate. The same is true for treatment: rest, blind epidural blood patch, fluoroscopy or CT-guided epidural blood patch, fibrin patch and surgery are discussed. Conclusión: Further research, especially multicentre controlled studies, is required to improve understanding of pathophysiology, diagnostic imaging, therapeutic approaches and to objectively assess clinical outcomes. Only then will diagnostic and treatment guidelines be evidence-based.

RESUMEN Introducción: La hipotensión intracraneal espontánea es un síndrome causado por la disminución del volumen de líquido cefalorraquídeo consecuencia de su fuga al espacio extradural. Aunque la ICHD-3 proporciona un alto nivel de especificidad diagnóstica, esta enfermedad puede manifestarse de forma atípica. Hasta en un 30% no es posible establecer el punto de escape, pero con el refinamiento de los exámenes de imágenes este porcentaje se ha reducido a un 15%-20%. Actualmente, su manejo no se encuentra estandarizado y las recomendaciones se basan en evidencia de limitada calidad metodológica, además de la variabilidad de protocolos entre distintos centros. Desarrollo En esta revisión actualizamos los procedimientos diagnósticos y terapéuticos. Por un lado, analizamos el rol de la resonancia nuclear magnética de encéfalo y médula espinal completa como primer paso diagnóstico y, por otro lado, señalamos los exámenes destinados a determinar la fuga de líquido cefalorraquídeo. Tal es el caso de la mielo-resonancia, la mielo-tomografía computarizada, tanto estándar, dinámica y por sustracción digital, además de la cisternografía con 111-Indium-DPTA. Sin embargo, determinar cuál de estos exámenes es el óptimo es objeto de debate. Lo mismo ocurre con el tratamiento: reposo; parche sanguíneo epidural a ciegas, parche guiado por fluoroscopia o tomografía computarizada, parche de fibrina; o cirugía. Conclusiones Se requiere de una mayor investigación, especialmente con trabajos multicéntricos controlados, para una mejor comprensión de la fisiopatología, el diagnóstico por imágenes, los enfoques terapéuticos y evaluación objetiva de los resultados clínicos. Solo así se establecerán pautas diagnósticas y de tratamiento validadas.

Based on the external impetus of social development and the internal demand for universities to return to the cultivation of abilities, modern universities are actively exploring the reform of the academy system, constructing high-quality ability-cultivation models, doing "addition" in the process of learning and living, and doing "subtraction" in the evaluation of the results of cultivation, achieving certain educational results. However, at the same time, the construction of academies is also facing difficulties in changing concepts, allocating quality resources, and the realistic dilemma of collaborative education between "academy" and "college". The bottleneck of academy development should be addressed by actively exploring the school's distinctive model, optimising top-level design, and enriching its spiritual culture. Facing the wave of reform in the academy system, universities should promote the localisation of the academy system in an orderly manner through deliberate thinking.

Abstract. The present article introduces an extensive approach that effectively addresses math word problems by leveraging the benefits of operator and intermediate template techniques with multi-head attention. Our method identifies a vital relationship between the mathematical statements and their corresponding mathematical equations. We examine the intricacies associated with math word problems containing multiple unknown variables, as they pose unique challenges compared to those with a single unknown variable. Furthermore, we extensively analyze math word problems involving fundamental mathematical operations such as addition, subtraction, division, and multiplication. In our experimental setup, we employ a sophisticated mechanism that leverages multi-head attention and enables our model to selectively focus on different aspects of the input, allowing it to capture the most relevant and recent information necessary for solving the problems more accurately. Our aim is to create a system that assists non-native English students throughout their academic endeavors. Our system is specifically designed to support them in effectively solving a broad spectrum of mathematical word problems.

Abstract Abduction creates challenges and dangers for the victim who call for the implementation of more effective measures in relation to the parent who fails to comply with the judicial decision regulating parental responsibilities in order to prevent offenses to the victim’s legal rights, which is characterized by its vulnerability due to its age dependence on the parent. It is questioned, with reference to the protection of the fundamental rights of the subtracted minor; the probative difficulties underlying the crime of child abduction; the presumption of innocence in favor of the defendant; the anticipation of criminal procedural protection and the taking of the minor’s statements the intensity and relevance of the injury, compared to a victim who is characterized by his vulnerability. In terms of conclusions, it is observed that the factual reality underlying subtraction requires the introduction of more effective and comprehensive legal mechanisms of guardianship to prevent non-compliance with court decisions, with the aim of strengthening the protection of children and parents victims of this type of crime within the framework of the exercise of parental authority. s questioned minor abduction defendant minors injury conclusions noncompliance non compliance decisions authority

Resumo A subtracção gera desafios e perigos para a vítima que clamam por implementação de medidas mais efectivas em relação ao progenitor incumpridor da decisão judicial de regulação das responsabilidades parentais de modo a prevenir ofensas a bem jurídicos da vitima que se caracteriza pela sua vulnerabilidade em razão da sua idade dependência face ao progenitor. Questiona-se, tendo em referência a protecção dos direitos fundamentais do menor subtraído; as dificuldades probatórias que subjaz ao crime de subtracção de menor; a presunção da inocência a favor do arguido; a antecipação da tutela processual penal e a tomada das declarações do menor. a a intensidade e a relevância da lesão, face a uma vítima que se caracteriza pela sua vulnerabilidade. Em sede de conclusões, observa-se que a realidade fáctica subjacente à subtracção carece da introdução de mecanismos legais de tutela mais efectivos e abrangentes de prevenirem incumprimentos das decisões dos tribunais, com o fito de reforçar a protecção das crianças e dos pais vítimas deste tipo de crime no quadro do exercício do poder paternal. Questionase, Questionase Questiona se, Questiona-se subtraído arguido lesão conclusões observase observa tribunais paternal

Resumen Introducción: La fístula dural arteriovenosa espinal (FDAVE) es una enfermedad vascular frecuentemente subdiagnosticada. El tratamiento puede ser microqui rúrgico o endovascular. Métodos: Estudio retrospectivo de una serie de pa cientes con FDAVE tratados por microcirugía entre los años 2010 y 2021. Fueron evaluados parámetros como edad, sexo, cuadro clínico pre y postoperatorio medido con las escalas de Aminoff-Logue y Rankin modificada (mRs). Los estudios diagnósticos se utilizaron para de terminar nivel lesional y resultados quirúrgicos. Resultados: Se incluyeron doce pacientes (10 hombres y 2 mujeres) con un promedio de edad de 60 años. El tiempo de evolución del cuadro clínico al diagnóstico fue menor a 12 meses salvo un caso de 32 meses. Las FDAVE fueron localizadas, 8 a nivel dorsal, 3 a nivel lumbar y una a nivel sacro. La arteria de Adamkiewicz se identificó en 5 casos en L1, 2 en D12, 2 en D10, 2 en D9 y un caso en D7. De los 12 pacientes operados, 3 fueron embolizados previamente; dos permanecieron estables en su evolución y 10 mejoraron uno o más puntos del mRs. No hubo complicaciones en el postoperatorio. Todos mostraron mejoría del edema medular en reso nancia magnética y la angiografía digital, luego de los 6 meses, fue negativa. El seguimiento promedio fue de 40 meses con un rango de 6 a 122 meses y ningún paciente presentó recidiva de la FDAVE. Conclusión: El tratamiento quirúrgico de las FDAVE es un método muy eficaz, de baja morbilidad y menor tasa de recurrencia comparado con el tratamiento en dovascular.

Abstract Introduction: Spinal dural arteriovenous fistula (SDA VF) is a rare vascular disease, of unknown etiology, fre quently underdiagnosed. Treatment can be microsurgical or endovascular. Methods: Retrospective and monocentric analysis of 12 SDAVF patients treated by microsurgery between 2010 and 2021. Parameters including age, sex, pre and postoperative clinical condition were analyzed according to modified Aminoff-Logue and Rankin scales. Diagnos tic studies such as magnetic resonance imaging (MRI), magnetic resonance angiogram (MRA) and spinal digital subtraction angiography (DSA), were evaluated for lesion level, as were surgical results. Results: Twelve patients (10 men and 2 women), average age: 60 years, were operated. The interval from symptom onset to diagnosis was <12 months in all cases except one (32 months). SDAVF locations were thoracic in 8 cases, between T6 and T12, 3 at lumbar spine (L1- L2) and at S1 in one case, with no difference regarding side. The Adamkiewicz artery was identified in 5 cases at L1, 2 at D12, 2 at D10, 2 at D9 and 1 at D7 (7 left-sided and 5 right-sided). Three of the 12 patients operated had undergone prior embolization. Postoperative neu rological outcomes showed: 2 patients remained stable and 10 improved one or more points on the mRs; no postoperative complications were observed. Follow-up MRI images improved in all cases and spinal DSA was negative at 6 months. Average follow-up was 40 months (range 6 to 122) and no patient presented recurrence. Conclusion: Microsurgical treatment of SDAVF proved to be efficient, with low morbidity and lower recurrence rates compared to endovascular results.

Abstract Background Despite previous studies indicating a moderate/high incidence of angiography headache (AH), there is still limited data about the risk factors associated with its occurrence. Objective The present study aimed to assess the associations among demographic, clinical, and technical characteristics of cerebral digital subtraction angiography (DSA) and the occurrence of AH. Methods Cross-sectional analytical observational study with a sample comprised of individuals with a recommendation for elective DSA. Clinical interviews were conducted to assess the occurrence of AH, using a standardized questionnaire. Results Among 114 subjects, the mean age was 52.8 (±13.8) years old, 75.4% (86/114) were women, 29.8% (34/114) had a history of migraines, and 10.5% (12/114) had chronic headaches. The overall frequency of AH was 45.6% (52/114). Of those, 88.4% (46/52) underwent 3D angiography, 7.7% (4/52) underwent aortography, and 1.9% (1/52) underwent both procedures. There was a statistically significant association between AH and previous history of migraine (odds ratio [OR]: 4.9; 95% confidence interval [CI] 1.62–14.7; p = 0.005) and 3D angiography (OR 6.62; 95%CI: 2.04–21.5; p = 0.002). Conclusions 3D angiography is strongly associated with the occurrence of AH, which has never been reported before. The association between a previous history of migraine and AH confirms the results of previous studies. moderatehigh moderate high , (AH) demographic clinical DSA (DSA Crosssectional Cross sectional questionnaire 11 subjects 528 52 8 52. ±13.8 138 13 (±13.8 old 754 75 4 75.4 86/114 86114 86 (86/114 women 298 29 29.8 34/114 34114 34 (34/114 migraines 105 10 5 10.5 12/114 12114 12 (12/114 headaches 456 45 6 45.6 52/114. 52114 52/114 . (52/114) those 884 88 88.4 46/52 4652 46 (46/52 D 77 7 7.7 4/52 452 (4/52 aortography 19 1 9 1.9 1/52 152 (1/52 procedures odds OR [OR] 4.9 49 95 CI [CI 1.62–14.7 162147 62 14 0.005 0005 0 005 6.62 662 95%CI 95CI 2.04–21.5 204215 2 04 21 0.002. 0002 0.002 002 0.002) before (AH ±13. (±13. 75. 86/11 8611 (86/11 29. 34/11 3411 3 (34/11 10. 12/11 1211 (12/11 45. 5211 52/11 (52/114 88. 46/5 465 (46/5 7. 4/5 (4/5 1. 1/5 15 (1/5 [OR 4. 1.62–14. 16214 0.00 000 00 6.6 66 2.04–21. 20421 ±13 (±13 86/1 861 (86/1 34/1 341 (34/1 12/1 121 (12/1 521 52/1 (52/11 46/ (46/ 4/ (4/ 1/ (1/ 1.62–14 1621 0.0 6. 2.04–21 2042 ±1 (±1 86/ (86/ 34/ (34/ 12/ (12/ 52/ (52/1 (46 (4 (1 1.62–1 162 0. 2.04–2 204 ± (± (86 (34 (12 (52/ ( 1.62– 16 2.04– 20 (8 (3 (52 1.62 2.04 (5 1.6 2.0 2.

Resumo Antecedentes Apesar de estudos prévios indicarem uma incidência moderada/alta de cefaleia da angiografia (CA), os dados sobre os fatores de risco associados à sua ocorrência ainda são relativamente escassos. Objetivo O presente estudo teve como objetivo avaliar as associações entre as características demográficas, clínicas e técnicas da angiografia cerebral por subtração digital (ACSD) e a ocorrência de CA. Métodos Estudo observacional analítico transversal com uma amostra composta por indivíduos com indicação de ACSD em caráter eletivo. Entrevistas clínicas foram realizadas utilizando um questionário padronizado para acessar a ocorrência de CA. Resultados Entre os 114 indivíduos, a idade média foi de 52,8 (±13,8) anos, 75,4% (86/114) eram mulheres, 29,8% (34/114) tinham histórico de enxaqueca e 10,5% (12/114) tinham cefaleia crônica. A frequência geral de CA foi de 45,6% (52/114). Desses, 88,4% (46/52) foram submetidos à angiografia 3D, 7,7% (4/52), à aortografia e 1,9% (1/52), aos dois procedimentos. Houve associação estatisticamente significativa entre CA e histórico prévio de enxaqueca (odds ratio [OR] 4,9; intervalo de confiança [IC] 95%: 1,62–14,7; p = 0,005) e angiografia 3D (OR 6,62; IC95%: 2,04–21,5; p = 0,002). Conclusões A angiografia 3D está fortemente associada à ocorrência de CA, o que é inédito na literatura. A associação entre um histórico de enxaqueca e a CA confirma os resultados de estudos anteriores. moderadaalta moderada alta , (CA) escassos demográficas (ACSD eletivo 11 528 52 8 52, ±13,8 138 13 (±13,8 anos 754 75 4 75,4 86/114 86114 86 (86/114 mulheres 298 29 29,8 34/114 34114 34 (34/114 105 10 5 10,5 12/114 12114 12 (12/114 crônica 456 45 6 45,6 52/114. 52114 52/114 . (52/114) Desses 884 88 88,4 46/52 4652 46 (46/52 D 77 7 7,7 4/52, 452 4/52 (4/52) 19 1 9 1,9 1/52, 152 1/52 (1/52) procedimentos odds OR [OR 4,9 49 IC [IC 95% 95 1,62–14,7 162147 62 14 0,005 0005 0 005 6,62 662 IC95% IC95 2,04–21,5 204215 2 04 21 0,002. 0002 0,002 002 0,002) literatura anteriores (CA ±13, (±13, 75, 86/11 8611 (86/11 29, 34/11 3411 3 (34/11 10, 12/11 1211 (12/11 45, 5211 52/11 (52/114 88, 46/5 465 (46/5 7, 4/5 (4/52 1, 15 1/5 (1/52 4, 1,62–14, 16214 0,00 000 00 6,6 66 IC9 2,04–21, 20421 ±13 (±13 86/1 861 (86/1 34/1 341 (34/1 12/1 121 (12/1 521 52/1 (52/11 46/ (46/ 4/ (4/5 1/ (1/5 1,62–14 1621 0,0 6, 2,04–21 2042 ±1 (±1 86/ (86/ 34/ (34/ 12/ (12/ 52/ (52/1 (46 (4/ (1/ 1,62–1 162 0, 2,04–2 204 ± (± (86 (34 (12 (52/ (4 (1 1,62– 16 2,04– 20 ( (8 (3 (52 1,62 2,04 (5 1,6 2,0 2,

The neoliberal economic model propagated since the 1990s in Brazil and the economic, educational and evaluation policies of public universities impacted the meaning of work, the organization of work and the mental health of university professors. The mercantilist view under the aegis of capitalism has transfigured the organization of teachers' work, making it precarious, based on individualism, competition, work overload and the subtraction of leisure time by working time. Due to Covid-19 and the need for health measures to protect life and reduce the spread of the virus, emergency work and remote teaching were imposed in higher education institutions, enhancing the reality of the precarious work of the teacher. Given this context, this theoretical essay points out some possible ways to deal with the challenges of public HEIs and aims to problematize the reality of public university teaching work before and during the Covid-19 pandemic.

El modelo económico neoliberal propagado desde la década de 1990 en Brasil y las políticas económicas, educativas y de evaluación de las universidades públicas impactaron el sentido del trabajo, la organización del trabajo y la salud mental de las(os) profesores universitarios. La visión mercantilista bajo la égida del capitalismo ha transfigurado la organización del trabajo docente, haciéndola precaria, basada en el individualismo, la competencia, la sobrecarga de trabajo y la sustracción del tiempo de ocio por el tiempo de trabajo. Debido al Covid-19 y la necesidad de medidas sanitarias para proteger la vida y reducir la propagación del virus, se impuso el trabajo de emergencia y la enseñanza a distancia en las instituciones de educación superior, realzando la realidad del trabajo precario de las(os) docentes. Ante este contexto, este ensayo teórico apunta algunas vías posibles para enfrentar los desafíos de las IES públicas y pretende problematizar la realidad del trabajo docente universitario público antes y durante la pandemia de la Covid-19.

O modelo econômico neoliberal propagado desde a década de 1990 no Brasil e as políticas econômicas, educacionais e de avaliação das universidades públicas impactaram no sentido do trabalho, na organização do trabalho e na saúde mental das(os) docentes universitários. A visão mercantilista sob a égide do capitalismo transfigurou a organização do trabalho dos professores, tornando-o precário, pautado no individualismo, na competição, na sobrecarga laboral e na subtração do tempo de lazer pelo tempo de trabalho. Devido à Covid-19 e à necessidade de medidas sanitárias para proteção da vida e diminuição da disseminação do vírus foram impostos o trabalho e o ensino remoto emergencial nas instituições de ensino superior, potencializando a realidade do trabalho precarizado do docente. Diante desse contexto, este ensaio teórico aponta alguns caminhos possíveis para lidarmos com os desafios da IES pública e tem como objetivo problematizar a realidade do trabalho docente antes e durante a pandemia da Covid-10.

Abstract Background As a progressive cerebrovascular disease, Moyamoya Disease (MMD) is a common cause of stroke in children and adults. However, the early biomarkers and pathogenesis of MMD remain poorly understood. Methods and material This study was conducted using plasma exosome samples from MMD patients. Next-generation high-throughput sequencing, real-time quantitative PCR, gene ontology analysis, and Kyoto Encyclopaedia of Genes and Genomes pathway analysis of ideal exosomal miRNAs that could be used as potential biomarkers of MMD were performed. The area under the Receiver Operating Characteristic (ROC) curve was used to evaluate the sensitivity and specificity of biomarkers for predicting events. Results Exosomes were successfully isolated and miRNA-sequence analysis yielded 1,002 differentially expressed miRNAs. Functional analysis revealed that they were mainly enriched in axon guidance, regulation of the actin cytoskeleton and the MAPK signaling pathway. Furthermore, 10 miRNAs (miR-1306-5p, miR-196b-5p, miR-19a-3p, miR-22-3p, miR-320b, miR-34a-5p, miR-485-3p, miR-489-3p, miR-501-3p, and miR-487-3p) were found to be associated with the most sensitive and specific pathways for MMD prediction. Conclusions Several plasma secretory miRNAs closely related to the development of MMD have been identified, which can be used as biomarkers of MMD and contribute to differentiating MMD from non-MMD patients before digital subtraction angiography. disease (MMD adults However understood Nextgeneration Next generation highthroughput high throughput sequencing realtime real time PCR performed ROC (ROC events miRNAsequence miRNA sequence 1002 1 002 1,00 guidance Furthermore miR13065p, miR13065p miRp miR 1306 5p, 5p p (miR-1306-5p miR196b5p, miR196b5p miRbp 196b b miR-196b-5p miR19a3p, miR19a3p miRap 19a 3p, 3p miR-19a-3p miR223p, miR223p 22 miR-22-3p miR320b, miR320b miRb 320b, 320b miR-320b miR34a5p, miR34a5p 34a miR-34a-5p miR4853p, miR4853p 485 miR-485-3p miR4893p, miR4893p 489 miR-489-3p miR5013p, miR5013p 501 miR-501-3p miR4873p 487 miR-487-3p prediction identified nonMMD non angiography 100 00 1,0 130 2 48 50 0 1, 13 4 5