This paper presents the stages of an acceleration program focused on chemical technologies. We demonstrate how this initiative contributes to the creation of new businesses, startups, and technology licensing from research developed at Brazilian universities. The case of the program Escale-se is discussed. There were 66 technologies submitted, and 14 were selected for the pre-acceleration phase. In this phase, various contents were worked on, such as creating a business model and aspects of scaling hard-science technologies. Teams were evaluated by panels with market specialists, and 6 were selected for the second phase: pre-scaling/proof of concept. Here, proponents were encouraged to validate the business model by connecting with potential clients and partners, as well as planning the development and testing of the product in a relevant environment. Finally, one team was classified for the last stage: scaling/go-to-market - where they received R$ 100,000.00 to scale up their technology and create strategies for raising investments. Four of the fourteen technologies selected for the program opened National Register of Legal Entities (CNPJ) and raised approximately R$ 4.5 M in investments from different sources. These results demonstrate that the methodology contributed to the entrepreneurial development of participating researchers and the raising of funds for the businesses created. startups universities Escalese Escale se discussed submitted 1 preacceleration pre phase hardscience hard science specialists prescaling/proof prescalingproof scaling/proof proof concept Here partners environment Finally stage scaling/gotomarket scalinggotomarket scaling/go go R 10000000 100 000 00 100,000.0 CNPJ (CNPJ 45 4 5 4. sources created prescaling scalingproof gotomarket scalinggo 1000000 10 0 100,000. 100000 100,000 10000 100,00 1000 100,0 100,

ABSTRACT Purpose: Although Brazil has a high prevalence of retinoblastoma, there is a lack of epidemiological data on the disease. Thus, in this study, we aimed to evaluate the epidemiological profile of patients diagnosed with retinoblastoma in the ophthalmology department of a pediatric tertiary referral hospital in Ceara, Brazil. Methods: A descriptive and cross-sectional study was conducted by retrospectively analyzing the clinical and socioeconomic data from the medical records of pediatric patients followed-up at the hospital between 2007 and 2021. Retinoblastoma was diagnosed on the basis of a fundoscopic or histopathologic examination. Results: The data of 105 patients were included in the study, and the mean patient age at the time of diagnosis was 1.7 years. Most of the patients were women (50.5%) and hailed from rural areas (57.4%), which was associated with a higher tumor stage. Of the 150 patients, 57.1% initially presented with leukocoria. Ocular hyperemia was associated with more advanced stages of retinoblastoma (p=0.004). Bilateral involvement was observed in 25.7% of the patients and at a significantly younger age (p=0.009). The presence of retinal detachment, vascularized lesions, and vitreous seeds significantly increased the likelihood of requiring enucleation. Discussion: This study presents an epidemiological description of retinoblastoma in Brazil, which highlights the significance of early detection. Delayed diagnosis is associated with a poorer visual prognosis and higher mortality rate, particularly in patients with unilateral disease. Risk factors for a more severe disease were retinal detachment, vascularized lesions, and vitreous seeds. The correlation between histopathological features and clinical outcomes was limited. Conclusion: Further studies are required to assess the influence of ocular hyperemia, fundoscopic assessment, and histopathologic findings on the prognosis of retinoblastoma. Moreover, it is critical to devise interventions to reduce the time-to-diagnosis in rural areas. Purpose Thus Ceara Methods crosssectional cross sectional followedup followed up 200 2021 examination Results 10 17 1 7 1. years 50.5% 505 50 5 (50.5% 57.4%, 574 57.4% , 57 4 (57.4%) stage 15 571 57.1 leukocoria p=0.004. p0004 p p=0.004 . 0 004 (p=0.004) 257 25 25.7 p=0.009. p0009 p=0.009 009 (p=0.009) detachment lesions enucleation Discussion detection rate limited Conclusion assessment Moreover timetodiagnosis 20 202 50.5 (50.5 57.4 (57.4% 57. p000 p=0.00 00 (p=0.004 2 25. (p=0.009 50. (50. (57.4 p00 p=0.0 (p=0.00 (50 (57. p0 p=0. (p=0.0 (5 (57 p=0 (p=0. ( p= (p=0 (p= (p

Over the last two decades, metabolomics has emerged as a pivotal tool in multidisciplinary research, providing invaluable insights into metabolome modulations and finding applications across various scientific domains, including medicine and agronomy. Nonetheless, the absence of standardized procedures in sample preparation, data acquisition, and documentation of data quality presents a significant challenge. This review underscores the critical importance of quality assurance and quality control (QA/QC) in untargeted metabolomics, advocating for the establishment of agreed-upon QA/QC reporting standards within the scientific community. We discuss the requisite quality controls at various stages of untargeted metabolomics studies, encompassing blank samples, pooled samples, and the utilization of external quality control samples. Methods for assessing accuracy, reproducibility, and identifying/correcting batch effects are addressed. Furthermore, emphasis is placed on standardizing the description of QA/QC data in scientific publications and repositories to foster reproducibility and transparency. We recommend the publication of QC data alongside studies in appropriate databases to facilitate data comparison and sharing among researchers, thereby enhancing the quality of untargeted metabolomics research. In summary, implementing standardized QA/QC data reporting, along with promoting best practices within the untargeted metabolomics community, is crucial for improving result quality and credibility and advancing research utilizing this powerful technique. decades domains agronomy Nonetheless preparation acquisition challenge QAQC QA (QA/QC agreedupon agreed upon community samples accuracy identifyingcorrecting identifying correcting addressed Furthermore transparency researchers summary technique

RESUMO A produção de grãos apresenta crescimento constante, entretanto, a capacidade estatística de armazenamento permanece deficitária no Brasil. A falta de estruturas e a precariedade e inadequação no armazenamento ocasionam perdas na pós-colheita, devido ação de fatores que interagem com os grãos, culminando na sua deterioração. Para reversão desses efeitos, o tratamento químico é realizado, contudo, busca-se por sua substituição por substâncias naturais devido a implicações ambientais e medicinais. Objetivou-se com esta revisão, a discussão de uma potencial estratégia sustentável para o tratamento de grãos armazenados, com foco no uso de compostos naturais com propriedades bioativas como antifúngica, antioxidante e inseticida, que os torna potenciais para serem estudados. Foram delineados compostos naturais que possuem propriedades úteis para aplicação no armazenamento de grãos. Pesquisas a respeito do emprego dos compostos naturais no tratamento de grãos são incipientes, carecendo de avanços na identificação de novos compostos promissores, melhor compreensão dos mecanismos de ação e otimização/desenvolvimento de processos de extração, aplicação e formulação eficazes que viabilizem o futuro uso das substâncias. constante entretanto Brasil póscolheita, póscolheita pós colheita, colheita pós-colheita deterioração efeitos realizado contudo buscase busca se medicinais Objetivouse Objetivou revisão armazenados antifúngica inseticida estudados incipientes promissores otimizaçãodesenvolvimento otimização desenvolvimento extração

ABSTRACT Grain production is steadily increasing; however, the static storage capacity remains inadequate in Brazil. The lack of proper facilities and the precarious and inadequate storage conditions lead to post-harvest losses due to factors interacting with the grains, causing their deterioration. Chemical treatments are commonly used to reverse these effects; however, their replacement with natural substances has been sought due to environmental and human health concerns. The objective of this review was to discuss a sustainable strategy for treating stored grains, focusing on the use of natural compounds with bioactive properties, such as antifungal, antioxidant, and insecticidal activities, with potential for further studies. Natural compounds with useful properties for application in grain storage were outlined. Research on the use of natural compounds in grain treatment is still in its early stages, requiring progress in identifying new promising compounds, understanding the mechanisms of action, and developing and optimizing effective extraction, application, and formulation processes to make the use of these substances viable. increasing however Brazil postharvest post harvest grains deterioration effects concerns antifungal antioxidant activities studies outlined stages action extraction viable

ABSTRACT: This study evaluated the effect of removing apical dominance at phenological stages on the agronomic traits of soybean cultivars. The experiment was conducted in the 2020/2021 growing season inthe teaching-experimental area of the Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Ibirubá, under a randomized block design in a split-plot arrangement, with three replications. The main plots were composed of five soybean cultivars (DM53i54 IPRO, Zeus IPRO, Lanza IPRO, DM5958 IPRO, and Delta IPRO), and the subplots consisted of the phenological stages of apical dominance removal (control, V2, V4, and V6). Morphological traits were evaluated at different stages. Differences were observed between cultivars, which followed their pre-defined morphologies. Apical dominance removal reduced aspects such as the number of nodes and legumes on the main stem and the first legumeinsertion height. Cultivars developed branching mechanismsas a compensation strategy, increasing the number of legumes on the branches by up to 130%. The removal of the shoot apex can modify morphological aspects in soybean plants,but their yield tends to be maintained. ABSTRACT 20202021 2020 2021 2020/202 teachingexperimental teaching experimental Education Sul Ibirubá splitplot split plot arrangement replications DM53i54 DMi DM i (DM53i5 IPRO DM595 , IPRO) control, control (control V2 V V4 V6. V6 . V6) predefined pre defined morphologies height strategy 130 130% plantsbut plants but maintained 2020202 202 2020/20 DM53i5 (DM53i DM59 13 202020 20 2020/2 DM53i DM5 1 20202 2 2020/

RESUMO: O presente artigo objetiva avaliar o efeito da remoção da dominância apical em estádios fenológicos, nos caracteres agronômicos de cultivares de soja. O experimento foi implantado na área didática-experimental do Instituto Federal de Educação e Tecnologia do Rio Grande do Sul, Campus Ibirubá, na safra 2020/2021, sob delineamento de blocos ao acaso, em arranjo de parcelas subdivididas, com três repetições. As parcelas principais eram compostas pelos cinco cultivares (DM53i54 IPRO, Zeus IPRO, Lança IPRO, DM5958 IPRO e Delta IPRO) e as subparcelas, pelos estádios fenológicos de remoção de dominância apical (testemunha, V2, V4 e V6). As características morfológicas foram avaliadas em diferentes estádios. Como resultados, verificaram-se diferenças entre os cultivares, que seguiram suas morfologias pré-definidas. A remoção de dominância apical, reduziu aspectos como o número de nós e legumes na haste principal, além da altura de inserção do primeiro legume. Como estratégia de compensação, os cultivares desenvolvem mecanismos de ramificação, acrescendo até 130% no número de legumes nos ramos. Verifica-se que a remoção do ápice caulinar é capaz de modificar aspectos morfológicos em plantas de soja, contudo, seu rendimento tende a ser mantido. RESUMO soja didáticaexperimental didática experimental Sul Ibirubá 20202021 2020 2021 2020/2021 acaso subdivididas repetições DM53i54 DMi DM i (DM53i5 DM595 subparcelas testemunha, testemunha (testemunha V2 V V6. V6 . V6) resultados verificaramse verificaram se prédefinidas. prédefinidas pré definidas. definidas pré-definidas principal legume compensação ramificação 130 ramos Verificase Verifica contudo mantido 2020202 202 2020/202 DM53i5 (DM53i DM59 13 202020 20 2020/20 DM53i DM5 1 20202 2 2020/2 2020/

This study highlights the synthesis of innovative polyurethane materials derived from Moringa oleifera oils extracted from two distinct sources. The oils were converted into their respective polyols through the in situ generated performic acid method. Diverse material characteristics were observed due to different agroclimatic and cultivation conditions for the sources. Extraction yields were 45.21% (source 1) and 40.32% (source 2), with acid values of 28.70 and 26.00 mg KOH per g of oil, respectively. Oleic acid constituted 79.87 and 67.11% of the oils composition, respectively. Nuclear magnetic resonance and Fourier transform infrared spectroscopy (FTIR) confirmed the hydroxylation of the oils. FTIR also identified the isocyanate structures in the synthesized polyurethane materials. Gel permeation chromatography analysis revealed a higher oligomer content in the polyol synthesized from the oil extracted from source 2. Thermogravimetric analysis demonstrated enhanced thermal stability post-oil conversion, highlighting decomposition stages for rigid and flexible segments. Differential scanning calorimetry indicated higher unsaturation in the oil extracted from source 1, resulting in an elevated crystallization temperature. Tensile testing showed increased elasticity as the [NCO]/[OH] ratio decreased in the material, emphasizing the influence of polyol and crosslinking agent concentrations on mechanical resistance of polyurethane materials. sources method 4521 45 21 45.21 1 4032 40 32 40.32 2, 2 , 2) 2870 28 70 28.7 2600 26 00 26.0 respectively 7987 79 87 79.8 6711 67 11 67.11 composition (FTIR postoil post conversion segments temperature NCO/OH NCOOH NCO / OH [NCO]/[OH 452 4 45.2 403 3 40.3 287 7 28. 260 0 26. 798 8 79. 671 6 67.1 45. 40. 67.

Brazil is home to a rich biodiversity of native edible fruits renowned for their health-promoting compounds and flavors. Among these, Eugenia uniflora L. (Brazilian pitanga) is particularly notable. The fruit varies in color from yellow to purple and is prized for its intense aroma and versatile taste profile. However, information about the compounds responsible for their nutritional and sensory potential is still limited. This study analyzed volatile compounds and metabolites in yellow, red and purple pitanga fruits (Eugenia uniflora) at various ripening stages, exploiting a metabolomics approach. Yellow pitanga had 30 volatile compounds, with esters (40%), terpenes (26.67%) and aldehydes (16.67%) constituting 83.34% of identified volatile compounds. Red pitanga featured 26 volatile compounds, primarily terpenes and esters (each 30.77%) and aldehydes (15.38%), making up 76.92%. Purple pitanga contained 39 volatile compounds, with terpenes and esters (each 35.90%) and aldehydes (17.95%), totaling 89.75% of identified volatile compounds. Across all pitanga types, 124 metabolites were identified, including saturated fatty acids (17.74%), terpenes (17.74%) and sugars (16.93%), constituting 52.41% of identified metabolites. Future studies should provide nutritional information, consumption methods and industrial applications for pitanga fruits, focusing on sensory analysis, health benefits, preservation and breeding to enhance bioactive compounds and flavor. healthpromoting promoting flavors these L Brazilian notable profile However limited stages approach 3 40%, 40 40% , (40%) 26.67% 2667 67 (26.67% 16.67% 1667 16 (16.67% 8334 83 34 83.34 2 each 30.77% 3077 77 15.38%, 1538 15.38% 15 38 (15.38%) 7692 76 92 76.92% 35.90% 3590 35 90 17.95%, 1795 17.95% 17 95 (17.95%) 8975 89 75 89.75 types 12 17.74%, 1774 17.74% 74 (17.74% 16.93%, 1693 16.93% 93 (16.93%) 5241 52 41 52.41 analysis benefits flavor 4 (40% 26.67 266 6 (26.67 16.67 166 1 (16.67 833 8 83.3 30.77 307 7 153 15.38 (15.38% 769 9 76.92 35.90 359 179 17.95 (17.95% 897 89.7 177 17.74 (17.74 169 16.93 (16.93% 524 5 52.4 (40 26.6 (26.6 16.6 (16.6 83. 30.7 15.3 (15.38 76.9 35.9 17.9 (17.95 89. 17.7 (17.7 16.9 (16.93 52. (4 26. (26. 16. (16. 30. 15. (15.3 76. 35. 17. (17.9 (17. (16.9 ( (26 (16 (15. (17 (2 (1 (15

RESUMO: Uma das causas de perda de produtividade em lavouras de cana está associada à espécie Diatraea saccharalis, também conhecida por broca da cana. Portanto, este estudo avaliou a viabilidade do uso de sensores hiperespectrais para obter a resposta espectral foliar da cana-de-açúcar em diferentes períodos de infestações, tanto a nível foliar quanto dossel, a fim de diagnosticar antecipadamente os danos da Diatraea saccharalis. O estudo contou com três variedades de cana-de-açúcar: CTC9003BT, CTC4 e RB966928. Em metade das parcelas foi utilizado o inseticida Altacor® para o controle de pragas. As coletas de dados ocorreram nas fases: brotação, perfilhamento, crescimento de colmos e início da maturação. Para avaliar os efeitos da broca na cana foi coletado os dados referentes ao conteúdo relativo de água (CRA), assinatura espectral foliar em laboratório e dossel, índices de vegetação (NDVI e MCARI), produtividade, pureza e ATR (Açúcar Total Recuperável). O maior CRA encontrado foi para a CTC9003BT (60,15%) sem inseticida e 59,0% com inseticida. As faixas espectrais do visível (400-680 nm) e infravermelho próximo (750-1300 nm) identificaram variações espectrais nas plantas com e sem broca. O percentual de broca apresentou correlações altas e negativas entre a produtividade, NDVI e ATR, com coeficientes de -0,68, -0,76 e -0,76, respectivamente. Os índices NDVI e MCARI foram eficazes na detecção de plantas sob estresse, contudo, sua variação é influenciada por múltiplos fatores, sendo difícil associá-los a um único problema (broca). RESUMO saccharalis Portanto canadeaçúcar açúcar infestações dossel CTCBT CTC BT RB966928 RB Altacor pragas fases brotação perfilhamento maturação CRA, , (CRA) MCARI, MCARI) Açúcar Recuperável. Recuperável . Recuperável) 60,15% 6015 60 15 (60,15% 590 59 0 59,0 400680 400 680 (400-68 nm 7501300 750 1300 (750-130 0,68, 068 68 -0,68 0,76 076 76 -0,7 0,76, respectivamente estresse contudo fatores associálos associá los (broca) RB96692 (CRA 60,15 601 6 1 (60,15 5 59, 40068 40 (400-6 750130 75 130 (750-13 0,68 06 -0,6 0,7 07 7 -0, (broca RB9669 60,1 (60,1 4006 4 (400- 75013 13 (750-1 0,6 0, -0 RB966 60, (60, (400 7501 (750- - RB96 (60 (40 (750 RB9 (6 (4 (75 ( (7

ABSTRACT: One of the causes of productivity loss in sugarcane cultivation has been associated with the species Diatraea saccharalis, also known as the sugarcane borer. Therefore, this study evaluated the feasibility of using hyperspectral sensors to obtain the leaf spectral response of sugarcane in different periods of infestation at leaf and canopy levels to diagnose D. saccharalis damage in advance. The study included three varieties of sugarcane: CTC9003BT, CTC4, and RB966928. The insecticide Altacor® was used to control pestsin half of the plots. Data collection occurred at the following stages: sprouting, tillering, stalke longation, and early maturation. Data regarding relative water content (RWC), leaf spectral signature in the laboratory and canopy, vegetation indices (NDVI and MCARI), productivity, purity, and total recoverable sugar (TRS) were collected to evaluate the borer effects on the sugarcane crop. The highest RWC was observed for CTC9003BT (60.15%) without insecticide and 59.0% with insecticide. The visible (400-680 nm) and near-infrared (750-1300 nm) spectral bands identified spectral variations in plants with and without sugarcane borer. The percentage of sugarcane borer showed high and negative correlations between productivity, NDVI, and TRS, with coefficients of -0.68, -0.76, and -0.76, respectively. The NDVI and MCARI indices effectively detect plants under stress, but their variation is influenced by multiple factors, making it difficult to associate them with a single problem (sugarcane borer). ABSTRACT Therefore D advance CTCBT CTC BT CTC4 RB966928 RB Altacor plots stages sprouting tillering longation maturation RWC, , (RWC) MCARI, MCARI) purity TRS (TRS crop 60.15% 6015 60 15 (60.15% 590 59 0 59.0 400680 400 680 (400-68 nm nearinfrared near infrared 7501300 750 1300 (750-130 0.68, 068 68 -0.68 0.76, 076 76 -0.76 respectively stress factors . borer) RB96692 (RWC 60.15 601 6 1 (60.15 5 59. 40068 40 (400-6 750130 75 130 (750-13 0.68 06 -0.6 0.76 07 7 -0.7 RB9669 60.1 (60.1 4006 4 (400- 75013 13 (750-1 0.6 -0. 0.7 RB966 60. (60. (400 7501 (750- 0. -0 RB96 (60 (40 (750 - RB9 (6 (4 (75 ( (7

Abstract Purpose: To describe the participatory process of community monitoring using aquatic insects as a tool to assess environmental quality in Cuitzmala y Purificacion basins. Methodological design: A participatory environmental monitoring model is proposed, which involves key actors, covering the upper, middle and lower part of each basin. A workshop was designed in appropriate way to the context of local actors and basin characteristics. The workshop consisted of four stages, involving theory and practice. Field diary was developed thought descriptive notes about what is seen and doing the participants. Results: Six community groups were formed, five in schools and one a Citizen Environmental Committee. Most participants found the workshop beneficial and expressed a desire for an increased number of monitoring sessions and additional monitoring sites. Participants successfully assessed their river section using aquatic insects, and it is recommended to provide technical support to strengthen monitoring skills and long-term monitoring. Research limitations: Still this action is considered an extracurricular activity. For this reason, is necessary work with professor to integrate these activities in the education program of the schools. Findings: Aquatic insects community monitoring strength and complement the scientific monitoring. The methodology used can be replicated in other coastal basins.

Resumen Objetivo: Describir el proceso participativo para el monitoreo comunitario a fin de evaluar la calidad ambiental de los ríos de las cuencas Cuitzmala y Purificación mediante un índice biótico multimétrico con insectos acuáticos previamente desarrollado para esta región. Diseño metodológico: Se propone un modelo de proceso participativo para el monitoreo ambiental. Con actores clave se seleccionaron localidades que abarcaron parte alta, media y baja de cada cuenca. Se diseñó un taller con base en protocolos para monitoreo, adecuado al contexto de las cuencas y actores elegidos. El taller consistió en cuatro etapas, en las que se capacitó con teoría y práctica. En un diario de campo se tomaron notas descriptivas respecto a lo que dijeron e hicieron los participantes. Resultados: Se conformaron seis grupos comunitarios, en cinco escuelas, y un Comité Ciudadano Ambiental. A la mayoría de los participantes les pareció bien el taller y les gustaría ampliar el número de monitoreos y los sitios a monitorear. Los participantes lograron evaluar su tramo de río con los insectos acuáticos y recomendaron continuar el acompañamiento técnico para fortalecer sus habilidades y asegurar el monitoreo a largo plazo. Limitaciones de la investigación: Aún esta actividad es considerada como extracurricular, por lo que es necesario trabajar con los docentes para que quede integrada en las materias del programa curricular de cada grado. Hallazgos: El monitoreo comunitario de los insectos acuáticos fortalece y complementa al monitoreo científico. Esta metodología puede ser replicada en otras cuencas costeras.

ABSTRACT Paracoccidioidomycosis (PCM) is a systemic disease endemic to Latin American countries, with a high impact in terms of morbidity, mortality and costs for the health system if patients progress to advanced stages. This work aimed to collect data published in publications on autochthonous cases of PCM, from the first cases diagnosed in Paraguay, with a description of the historical context and identifying the pioneers in the diagnosis in Paraguay, following a chronological order, to the most recently reported cases. Methodology: search in national libraries and online databases of PCM cases in Paraguay, published in national historical scientific journals and other sources available in print format, and more recent scientific articles available in electronic format, respectively. Results: 479 cases of PCM were identified in publications between the years 1935 and 2023, corresponding to autochthonous cases and whose diagnoses were made in Paraguayan territory. Dr. Juan Boggino and collaborators were responsible for the first diagnoses in the country. The predominant clinical form was chronic. The average age was 45.78 years. The vast majority of patients diagnosed were from the Eastern Region of the country, predominantly male farmers. Conclusion: PCM is an endemic disease in Paraguay. Since the first cases were diagnosed and until today, patients with a severe and disabling course of the disease have been detected, which demonstrates the need to disseminate its knowledge and expand the early diagnostic capacity at the national level. Due to its clinical pleomorphism and its ability to simulate other diseases, it is important to include PCM as a differential diagnosis for patients who present risk factors for the development of the disease.

RESUMEN La Paracoccidioidomicosis (PCM), es una enfermedad sistémica endémica de países de América Latina, con alto impacto en términos de morbilidad, mortalidad y costos para el sistema de salud si los enfermos progresan a sus estadios avanzados. Este trabajo tuvo como objetivo recopilar datos divulgados en publicaciones sobre casos autóctonos de PCM, desde los primeros casos diagnosticados en Paraguay, con una descripción del contexto histórico e identificando a los pioneros en el diagnóstico en Paraguay, siguiendo un orden cronológico, hasta los casos más recientemente informados. Metodología: búsqueda en bibliotecas nacionales y bases de datos online de casos de PCM en Paraguay, publicados en revistas científicas históricas nacionales y otras fuentes disponibles en formato impreso, y artículos científicos más recientes disponibles en formato electrónico, respectivamente. Resultados: Se identificaron 479 casos de PCM en publicaciones entre los años 1935 y 2023, correspondientes a casos autóctonos y cuyos diagnósticos fueron realizados en territorio paraguayo. El Dr. Juan Boggino y colaboradores fueron los responsables de los primeros diagnósticos en el país. La forma clínica predominante fue la crónica. La media de edad de 45,78 años. La gran mayoría de los pacientes diagnosticados fueron oriundos de la Región Oriental del país, predominantemente hombres agricultores. Conclusión: La PCM es una enfermedad endémica del Paraguay, desde los primeros casos diagnosticados y hasta hoy en día, son detectados pacientes con una evolución grave y discapacitante de la enfermedad, lo que demuestra la necesidad de la difusión de su conocimiento y ampliación de la capacidad diagnóstica precoz a nivel nacional. Debido a su pleomorfismo clínico y su capacidad de simular otras enfermedades, es importante incluir a la PCM como diagnóstico diferencial de pacientes que presenten factores de riesgo para el desarrollo de la enfermedad.

Abstract Introduction: The nursing process is the method that allows us to administer care to people with chronic diseases through the disease stages, that is, assessment, diagnostic reasoning, nursing care plan and evaluation. Objective: Evaluate a nursing care plan for an older adult with type 2 diabetes mellitus and osteoporosis with a focus on therapeutic health education. Methodology: Observational, descriptive, and longitudinal clinical case study of a 63-year-old patient with diabetes mellitus and osteoporosis; the Marjory Gordon instrument was used for assessment, and standardized language was used for diagnostic reasoning, planning, execution and evaluation. Under bioethical principles, this is a minimal risk research, and the privacy and data of the elderly are protected. Results: Alteration was found in the pattern of perception/maintenance of health, nutritional/metabolic, exercise activity and coping with stress; with the establishment of activities to control glucose, priority was given to prescribed diet, exercise, adherence to treatment and coping with stress. Acceptance of the disease, learning to take capillary glucose and glycemic control was achieved, as well as adherence to the prescribed diet and exercise. Conclusions: Therapeutic health education achieved adherence to pharmacological and non-pharmacological treatment, as well as the acceptance of the health status, which allows acquiring self-control of the disease. Continuous and long-term follow-up is important due to the pathological progress, age and general deterioration of the patient.

Abstrato Introdução. O processo de enfermagem é o método que nos permite administrar a assistência a pessoas com doenças crônicas por meio dos estágios da doença, ou seja, avaliação, raciocínio diagnóstico, plano de assistência de enfermagem e avaliação. Objetivo: Avaliar um plano de cuidados de enfermagem para um adulto mais velho com diabetes mellitus tipo 2 e osteoporose com foco na educação terapêutica em saúde. Metodologia: Estudo de caso clínico observacional, descritivo e longitudinal de uma paciente de 63 anos com diabetes mellitus e osteoporose; para a avaliação foi utilizado o instrumento Marjory Gordon para raciocínio diagnóstico, planejamento, execução e avaliação, para raciocínio diagnóstico, planejamento, execução e avaliação, foi utilizada a linguagem padronizada. De acordo com os princípios bioéticos, essa é uma pesquisa de risco mínimo, e a privacidade e os dados dos idosos são protegidos. Resultados: Foi encontrada alteração no padrão de percepção/manutenção da saúde, nutricional/metabólico, atividade física e enfrentamento do estresse; com o estabelecimento de atividades para controlar a glicose, a prioridade foi dada à dieta prescrita, aos exercícios, à adesão ao tratamento e ao enfrentamento do estresse. Houve aceitação da doença, aprendizado da medição da glicose capilar e controle glicêmico, além de adesão à dieta e aos exercícios prescritos. Conclusões: A educação terapêutica em saúde conseguiu a adesão ao tratamento farmacológico e não farmacológico, bem como a aceitação do estado de saúde, que permite adquirir o autocontrolo da doença, sendo importante a monitorização contínua e a longo prazo da evolução patológica, da idade e da deterioração geral do paciente.

Resumen Introducción: El proceso de enfermería es el método que nos permite administrar los cuidados a personas con enfermedades crónicas a través de sus etapas: valoración, razonamiento diagnóstico, plan de cuidados de enfermería y evaluación. Objetivo: Evaluar un plan de cuidados de enfermería a una adulta mayor con diabetes mellitus tipo 2 y osteoporosis con enfoque a la educación para la salud terapéutica. Metodología: Estudio de caso clínico, observacional, descriptivo y longitudinal, a paciente de 63 años con diabetes mellitus y osteoporosis; para la valoración se empleó el instrumento de Marjory Gordon, para el razonamiento diagnóstico, planeación, ejecución y evaluación se utilizó el lenguaje estandarizado de enfermería. Bajo los principios bioéticos es una investigación de riesgo mínimo, se protege la privacidad y datos del adulto mayor. Resultados: Se encontró alteración en el patrón percepción / mantenimiento de la salud, nutricional / metabólico, actividad ejercicio y afrontamiento del estrés; estableciendo actividades para el control de su glucosa, se priorizó en dieta prescrita, ejercicio, adherencia al tratamiento y afrontamiento al estrés. Se logró aceptación de la enfermedad, aprendizaje de toma de glucosa capilar y control glucémico, además del apego a dieta y ejercicio prescrito. Conclusiones: La educación para la salud terapéutica logró el apego al tratamiento farmacológico y no farmacológico, así como la aceptación del estado de salud le permite adquirir el autocontrol de su enfermedad, es importante el seguimiento continuo y a largo plazo por el avance patológico, edad y deterioro general de la paciente.

Abstract Introduction: The master's degree program in nursing offered by the Universidad Autónoma de Sinaloa through the Culiacan School of Nursing contemplates that graduates should develop competencies and provide answers to problems related to nursing care. Objective: To describe experiences of graduates of the master's degree in nursing from the Culiacan School of Nursing. Methodology: Qualitative, descriptive, phenomenological, and interpretative study using the technique of in-depth interviews, supported by a semi-structured guide and with informed consent, applied to six graduates of the master's degree in nursing. The data were processed through thematic content analysis by De Souza Minayo in 3 stages: ordering and open coding, data classification, and horizontal and cross-sectional analysis, with which a category and two subcategories were obtained. The final analysis was carried out through an inflection from empirical to theoretical and vice versa. Results: In the experiences lived by the graduates, emotions experienced during the development of research competencies were identified; these emotions affected their cognitive process by living with stress, despair, fear, or depression, and these emotions led them to be competent in research, database search, use of software, and publishing skills. Conclusions: After their experiences in the master's degree program in nursing, the graduates showed that they had lived emotions that affected their mental health, facing physiological and emotional problems derived from the stress experienced. As for their research skills, they reported being able to search databases, perform critical analysis, and even publish a scientific article.

Abstrato Introdução: O programa de mestrado em enfermagem oferecido pela Universidade Autônoma de Sinaloa, por meio da Faculdade de Enfermagem de Culiacán, contempla que os graduados desenvolvam competências que respondam aos problemas relacionados ao cuidado de enfermagem. Objetivo: Descrever as experiências da egressa do mestrado em enfermagem da Faculdade de Enfermagem de Culiacán. Metodologia: Estudo qualitativo, descritivo, fenomenológico e interpretativo, técnica: entrevistas em profundidade, com apoio de roteiro semiestruturado, sob consentimento informado a seis egressos do programa de mestrado em enfermagem. Dados processados através da análise de conteúdo temática de Souza Minayo em 3 etapas: ordenação e codificação aberta, classificação dos dados, análise horizontal e transversal, obtenção de uma categoria e duas subcategorias, análise final através da inflexão do empírico para o teórico e vice-versa. Resultados: Nas experiências vividas pelos egressos foram identificadas emoções vivenciadas durante o desenvolvimento das competências de pesquisa, onde as emoções afetaram seu processo cognitivo ao conviver com estresse, desespero, medo ou depressão e nas competências de pesquisa os levaram a serem competentes, realizar banco de dados pesquisa, uso de software e capacidade de publicar. Conclusões: Os egressos evidenciaram após suas vivências no mestrado em enfermagem que vivenciaram emoções que afetaram sua saúde mental, ao enfrentarem problemas fisiológicos e emocionais derivados do estresse vivenciado, para o desenvolvimento de habilidades de pesquisa que relataram ser capazes de realizar uma busca em bases de dados, uma análise crítica, até a publicação de um artigo científico.

Resumen Introducción: El programa de maestría en enfermería que oferta la Universidad Autónoma de Sinaloa a través de la Facultad de Enfermería Culiacán, contempla que los egresados desarrollen competencias, que den respuesta a problemas relacionados con el cuidado enfermero. Objetivo: Describir las experiencias del egresado de la maestría en enfermería de la Facultad de Enfermería Culiacán. Metodología: Estudio cualitativo, descriptivo, fenomenológico e interpretativo, empleando la técnica de entrevistas a profundidad, con apoyo de guía semiestructurada, bajo consentimiento informado a seis egresados del programa de maestría en enfermería. Datos procesados a través de análisis de contenido tipo temático por de Souza Minayo en 3 etapas: ordenamiento y codificación abierta, clasificación de datos, análisis horizontal y transversal, obteniendo una categoría y dos subcategorías, análisis final a través de inflexión de empírico a teórico y viceversa. Resultados: En las experiencias vividas por los egresados se identificaron emociones vividas durante el desarrollo de competencias en investigación, donde las emociones afectaron su proceso cognitivo al vivir con estrés, desesperación, temor o depresión y en competencias en investigación los llevaron a ser competentes, al realizar búsqueda en bases de datos, uso de software, y habilidad para publicar. Conclusiones: Los egresados evidenciaron tras sus experiencias en la maestría en enfermería haber vivido emociones que afectaron su salud mental, al enfrentar problemas fisiológicos y emocionales derivados del estrés experimentado, al desarrollo de competencias en investigación refirieron ser capaces de realizar una búsqueda en bases de datos, un análisis crítico, hasta lograr publicar un artículo científico.

Abstract Introduction: Almost 800 female deaths occur daily due to preventable causes associated with complications during or after pregnancy or childbirth, equivalent to two maternal deaths per minute. Objective: To develop a nursing care process for a pregnant woman who suffered from hyperthyroidism using diagnostic taxonomies, results and nursing interventions with a focus on Orem's theory. Methodology: Case study of a pregnant woman treated in a second level care hospital, the Orem assessment guide was used, developing the stages: assessment, diagnosis, planning, execution and evaluation, individualized care plans were designed and executed. Privacy was protected by omitting identity, respecting the rights and well-being of the participant. Results: The risk conditioning factor that compromised the health of the mother-child binomial gave way to care planning aimed at the process of ineffective motherhood and ineffective self-management of health, establishing interventions such as high-risk pregnancy care and teaching the process of illness and prescribed medications, an improvement was obtained in the patient's health status, which allowed her discharge and adequate management of the high-risk pregnancy. Conclusion: The nursing care process exposed the context in which the pregnant woman with known uncontrolled pathology is admitted, which compromised maternal-fetal well-being. Nursing education is required to promote preconception maternal health for future pregnancies.

Abstrato Introdução: Quase 800 mortes femininas ocorrem diariamente por causas evitáveis associadas a complicações durante ou após a gravidez ou o parto, o equivalente a duas mortes maternas por minuto. Objetivo: Desenvolver um processo de cuidado de enfermagem a uma gestante portadora de hipertireoidismo utilizando taxonomias diagnósticas, resultados e intervenções de enfermagem com enfoque na teoria de Orem. Metodologia: Estudo de caso de uma gestante atendida em um hospital de atenção secundária, utilizou-se o guia de avaliação de Orem, desenvolvendo as etapas: avaliação, diagnóstico, planejamento, execução e avaliação, foram desenhados e executados planos de cuidados individualizados. A privacidade foi protegida pela omissão da identidade, respeitando os direitos e o bem-estar do participante. Resultados: O fator condicionante de risco que comprometia a saúde do binômio mãe-filho deu lugar ao planejamento do cuidado voltado ao processo de maternidade ineficaz e à autogestão ineficaz da saúde, estabelecendo intervenções como o cuidado à gravidez de alto risco e ensinando o processo e medicamentos prescritos, houve uma melhora no estado de saúde da paciente, o que permitiu sua alta e o gerenciamento adequado da gravidez de alto risco. Conclusão: O processo de cuidado de enfermagem expôs o contexto em que a gestante com patologia conhecida não controlada é internada, o que compromete o bem-estar materno-fetal. A educação em enfermagem é necessária para promover a saúde materna pré-concepcional em futuras gestações.

Resumen Introducción: Casi 800 muertes de mujeres en forma diaria ocurren por causas prevenibles asociadas a complicaciones durante o después del embarazo o el parto, equivaliendo dos muertes maternas por minuto. Objetivo: Desarrollar un proceso de atención de enfermería a gestante que cursó con hipertiroidismo empleando las taxonomías diagnósticas, resultados e intervenciones de enfermería con enfoque de la teoría de Orem. Metodología: Estudio de caso a mujer gestante atendida en hospital de segundo nivel de atención, se empleó la guía de valoración de Orem desarrollando las etapas: valoración, diagnóstico, planeación, ejecución y evaluación, se diseñaron y ejecutaron planes de cuidados individualizados. Se protegió la privacidad omitiendo identidad, respetando los derechos y bienestar de la participante. Resultados: El factor condicionante de riesgo que comprometía la salud del binomio madre-hijo, dio paso a la planificación del cuidado encaminado al proceso de maternidad ineficaz y autogestión ineficaz de la salud, estableciendo intervenciones como cuidados del embarazo de alto riesgo y enseñanza del proceso de enfermedad y medicamentos prescritos, se obtuvo mejora en el estado de salud de la paciente, lo que permitió su alta y un adecuado manejo del embarazo de alto riesgo. Conclusión: El proceso de atención de enfermería expuso el contexto en el que ingresa la mujer gestante con patología conocida no controlada, lo que comprometía el bienestar materno-fetal. Se requiere educación por parte de enfermería para fomentar la salud materna preconcepcional para futuros embarazos.

RESUMEN El artículo tiene por objetivo caracterizar la evolución histórica de la formación permanente de los directivos de las escuelas pedagógicas en Cuba y su gestión. Para ello se establecieron las siguientes etapas: la primera desde 1959- 1974, la segunda de 1975- 2009 y la tercera del 2010 hasta la actualidad. Además, para en análisis del mencionado proceso, se plantean indicadores homogéneos que permitieron describir su comportamiento en cada uno de las etapas establecidas.

ABSTRACT The article aims to characterize the historical evolution of the permanent training of the directors of the pedagogical schools in Cuba and their management. For this, the following stages were established. The first from 1959-1974, the second form 1975-2009 and the third from 2010 to the present. In addition, for the analysis of the aforementioned process, homogeneous indicators are proposed that allow describing its behavior in each of the established stages.

RESUMEN La presente investigación parte de un análisis empírico y teórico vinculando estos con los componentes de la preparación del tiro con arco, lo que permite diagnosticar el estado actual del problema y el desempeño profesional, que permitió arribar a conclusiones. La importancia radica en las potencialidades que se puede lograr en el proceso de interiorización para el desarrollo de los profesores. La estrategia está estructurada por cinco etapas: diagnóstico, planificación de las formas organizativas de superación, ejecución, evaluación y control, así como un conjunto de acciones que garantizan su operatividad en la práctica.

ABSTRACT The present research starts from an empirical and theoretical analysis linking these, with the components of archery preparation, which allows diagnosing the current state of the problem and the professional performance, which allowed arriving at conclusions. The importance lies in the potentialities that can be achieved in the internalization process for the development of teachers. The strategy is structured in five stages: diagnosis, planning of the organizational forms of professional development, execution, evaluation and control, as well as a set of actions that guarantee its operability in practice.