Abstract While early studies on electoral strategies argue that Brazilian system encourages “personal vote” and the creation of geographically located electoral strongholds, latest studies show that the most effective electoral strategy is vote dispersion. According to the contextual perspective, people vote for candidates whose political messages they have access to and who correspond to the demands of the places where they live. Based on the construction of a database regarding the legislative elections from 2010 to 2018 we seek to interpret the results found using this perspective. Starting from the hypothesis of a vote ruled by the way information is diffused in space, we find that most candidates have their strongest vote in their municipality’s electoral domicile, that those with only municipal experience show a voting pattern consistent with the “friends and neighbors” effect, and that there is a party coordination in the formation of candidate lists.Keywords: localism; electoral concentration; electoral strategies; electoral behaviour; electoral geography. personal strongholds dispersion perspective live 201 space municipalitys municipality s domicile friends neighbors effect lists.Keywords listsKeywords lists Keywords localism concentration behaviour geography 20 2

Resumen Mientras que los primeros estudios sobre estrategias electorales sostenían que el sistema adoptado en Brasil fomenta el “voto personal” y la creación de bastiones electorales geográficamente localizados, estudios más recientes demuestran que la estrategia electoral más eficaz es la dispersión de los votos. Según la perspectiva contextual, las personas votan a candidatos a cuyos mensajes políticos tienen acceso y que corresponden a las exigencias de los lugares donde viven. A partir de la construcción de una base de datos sobre las elecciones legislativas de 2010 a 2018, tratamos de interpretar los resultados encontrados desde esta perspectiva. Partiendo de la hipótesis de que el voto se rige por la forma en que se difunde la información en el espacio, comprobamos que la mayoría de los candidatos obtienen el mayor número de votos en su domicilio electoral declarado, que los que sólo tienen experiencia municipal muestran un patrón de voto coherente con el efecto “amigos y vecinos” y que existe una coordinación partidista en la formación de las listas. personal localizados contextual viven 201 2018 espacio declarado amigos vecinos listas 20 2

Résumé Alors que les premières études sur les stratégies électorales soutiennent que le système adopté au Brésil encourage le “vote personnel” et la création de bastions électoraux géographiquement localisés, des études plus récentes montrent que la stratégie électorale la plus efficace est la dispersion des votes. Selon la perspective contextuelle, les électeurs votent pour les candidats dont ils ont accès aux messages politiques et qui correspondent aux demandes des lieux où ils vivent. En construisant une base de données sur les élections législatives de 2010 à 2018, nous cherchons à interpréter les résultats trouvés en utilisant cette perspective. Partant de l’hypothèse d’un vote régi par la manière dont les informations sont diffusées dans l’espace, nous constatons que la plupart des candidats obtiennent leur plus grand nombre de votes dans leur domicile électoral déclaré, que ceux ayant seulement une expérience municipale présentent un schéma de vote cohérent avec l’effet “amis et voisins” et qu’il existe une coordination partisane dans la formation des listes. personnel localisés contextuelle vivent 201 2018 lhypothèse l hypothèse dun d lespace, lespace espace, espace l’espace déclaré leffet effet amis voisins quil qu il listes 20 2

Resumo Enquanto os primeiros estudos sobre estratégias eleitorais argumentam que o sistema adotado no Brasil incentiva o “voto pessoal” e a criação de redutos eleitorais geograficamente localizados, estudos mais recentes demonstram que a estratégia eleitoral mais efetiva é a dispersão dos votos. Segundo a perspectiva contextual, as pessoas votam nos candidatos a cujas mensagens políticas têm acesso e que correspondem às demandas dos lugares onde vivem. A partir da construção de um banco de dados sobre as eleições legislativas de 2010 a 2018, buscamos interpretar os resultados encontrados utilizando essa perspectiva. Partindo da hipótese de uma votação regida pela forma como as informações são difundidas no espaço, encontramos que a maioria dos candidatos tem sua maior votação no seu domicílio eleitoral declarado, que os com apenas experiência municipal apresentam um padrão de votação condizente com o efeito de “amigos e vizinhos” e que existe uma coordenação partidária na formação das listas. voto pessoal localizados votos contextual vivem 201 2018 espaço declarado amigos vizinhos listas 20 2

Résumé Il y a toujours un scepticisme quant à savoir si un membre élu peut exercer une influence au Conseil de Sécurité des Nations Unies (CSNU). Cet article réévalue comment le Brésil, l’Inde et l’Afrique du Sud ont tenté d’influencer le processus de prise de décision du CSNU en tant que membres pendant la période 2010-2012. Il aborde la dynamique et les pratiques du Conseil, la centralité des cinq membres permanents (P5) et les moyens utilisés par les trois pays pour atteindre leurs objectifs de politique étrangère. À travers ces cas spécifiques, cet article montre que bien qu’il y ait de la place pour un membre élu pour influencer le Conseil, il est difficile de défier la prédominance du P5 même en profitant des opportunités et en s’engageant avec les principaux acteurs du CSNU. . (CSNU) Brésil lInde l Inde lAfrique Afrique dinfluencer d 20102012. 20102012 2010 2012. 2012 2010-2012 P (P5 étrangère spécifiques quil qu sengageant s engageant (CSNU 2010201 201 2010-201 (P 201020 20 2010-20 20102 2 2010-2 2010-

Abstract There is always scepticism about the extent to which an elected member of the United Nations Security Council (UNSC) can meaningfully exert influence. This article reassesses how, between 2010 and 2012, Brazil, India, and South Africa tried to leverage their membership to influence UNSC decision-making processes. It addresses the Council’s dynamics and practices, the centrality of its five permanent members (P5), and the ways these countries achieve their foreign policy objectives. Through country-specific cases, this article shows that although there is space for an elected member to influence the Council, challenging the predominance of the P5 remains difficult, even by seizing opportunities and engaging with key UNSC players. (UNSC how 201 2012 Brazil India decisionmaking decision making processes Councils s practices P5, P , (P5) objectives countryspecific country specific cases difficult players 20 (P5 2 (P

Resumen Siempre existe escepticismo sobre si un miembro electo puede ejercer influencia en el Consejo de Seguridad de las Naciones Unidas (CSNU). Este artículo reevalúa cómo Brasil, India y Sudáfrica intentaron influir en el proceso de toma de decisiones del CSNU como miembros en el periodo 2010-2012. Examina la dinámica y las prácticas del Consejo, la centralidad de los cinco miembros permanentes (P5) y las formas en que los tres países alcanzan sus objetivos de política exterior. A través de estos casos concretos, este artículo muestra que, aunque un miembro electo tiene margen para influir en el Consejo, es difícil desafiar el predominio de los P5 incluso aprovechando las oportunidades y comprometiéndose con los actores clave del CSNU. . (CSNU) Brasil 20102012. 20102012 2010 2012. 2012 2010-2012 P (P5 exterior concretos (CSNU 2010201 201 2010-201 (P 201020 20 2010-20 20102 2 2010-2 2010-

Resumo Há sempre ceticismo sobre se um membro eleito pode exercer influência no Conselho de Segurança das Nações Unidas (CSNU). Este artigo reavalia como Brasil, Índia e África do Sul tentaram influenciar o processo de tomada de decisão do CSNU como membros no período 2010-2012. Aborda a dinâmica e as práticas do Conselho, a centralidade dos cinco membros permanentes (P5) e as formas utilizadas pelos três países para atingir seus objetivos de política externa. Por meio desses casos específicos, este artigo mostra que, embora haja espaço para um membro eleito influenciar o Conselho, é difícil desafiar a predominância do P5 mesmo aproveitando oportunidades e engajando-se com os principais atores do CSNU. . (CSNU) Brasil 20102012. 20102012 2010 2012. 2012 2010-2012 P (P5 externa específicos que engajandose engajando (CSNU 2010201 201 2010-201 (P 201020 20 2010-20 20102 2 2010-2 2010-

Résumé Cet article a pour but de démontrer la pertinence de l´approche transversale des chiffres et des cartes afin de mettre en évidence le pouvoir performatif qui se dégage de leurs intersections tecnhopolitiques telles que le concept de densité de population et la régionalisation du territoire. Appliquée au Brésil, l´étude croisée met en lumière des aspects du processus de construction de l´État, de la centralisation de l´autorité politique et de la création de nouvelles catégories de personnes et d´espaces de gouvernement. Pour ce faire, les tendances qui ont rapproché la statistique et la cartographie au cours de l´Empire brésilien y sont annalysées, en comprenant leur rôle en tant qu´instruments descriptifs du pouvoir souverain. De même, l´article aborde les circonstances qui conduissent à l´importance croissante des chiffres et des cartes comme une référente commune pour l´action collective et la production d´identités sociales. Basé sur le cadre de la sociologie de la quantification, l´article s´intéresse à l´émergence de la cartographie statistique et la régionalisation croissante des données officielles entre les années 1920 et 1940, liée à une nouvelle façon de definir la «brésilité », d´ordonner le territoire et de gouverner la population. On conclut que quantifier, c´est aussi visualiser et imaginer des grandeurs démographiques et économiques dans une spatialité cohérente et unitaire une fois stabilisée par des conventions d´équivalence. lapproche l approche Brésil létude étude lÉtat État l´État lautorité autorité despaces d espaces gouvernement faire lEmpire Empire annalysées quinstruments qu instruments souverain même larticle limportance importance laction action didentités identités sociales quantification sintéresse s intéresse lémergence émergence 192 1940 brésilité » dordonner ordonner quantifier cest c est déquivalence équivalence d´équivalence 19 194 1

Abstract This article takes a cross-disciplinary approach to numbers and maps to demonstrate the performative power that emerges from their technopolitical intersections, such as the concept of population density and regional delineation of territory. Applied to the Brazilian context, this combined analysis sheds light on aspects related to the construction of State authority and its power to create categories of people and places. To do so, this paper examines trends that bring statistics and cartography together in the Brazilian Empire, indicating a common status for maps and numbers as descriptive instruments of sovereign power, including their modes of use and conditions for producing and validating truth. Subsequently, it addresses the factors leading to the growing importance of numbers and maps for collective action and the production of shared identities. Drawing on references from the sociology of quantification, this paper focuses on the emergence of statistical cartography and the increasing regionalization of official data between the 1920s and 1940s – linked to a new way of defining Brazilian identity, organizing territory, and managing population. It concludes that quantifying is also visualizing demographic and economic quantities in a coherent and unitary spatiality, once stabilized by conventions of equivalence. crossdisciplinary cross disciplinary intersections territory context places so Empire truth Subsequently identities quantification s identity spatiality equivalence

Resumen Este artículo realiza un abordaje cruzado de números y mapas con el fin de evidenciar el poder performativo que emerge de sus intersecciones tecnopolíticas, como el concepto de densidad poblacional y el recorte regional del territorio. Aplicado al caso brasilero, el análisis combinado ilustra aspectos relativos a la construcción de la autoridad del Estado y su poder de crear categorías de personas y lugares. Para ese propósito, examinamos las tendencias que aproximan la estadística de la cartografía en Brasil Imperio y que indican un estatuto común a mapas y números como instrumentos descriptivos del poder soberano, sus modalidades de uso y sus condiciones de producción y validación de la verdad. Luego, abordamos los factores que conducen a la creciente importancia de los números y de los mapas para la acción colectiva y para la producción de identidades compartidas. Con base en las referencias de la sociología de la cuantificación, nos enfocamos en la emergencia de la cartografía estadística y en la creciente regionalización de los datos oficiales entre las décadas de 1920 y 1940, vinculadas a un nuevo modo de definir la “brasilidad”, ordenar el territorio y administrar la población. Concluimos que cuantificar es también visualizar cantidades demográficas y económicas en una espacialidad coherente y unitaria, una vez estabilizada por convenciones de equivalencia. tecnopolíticas brasilero lugares propósito soberano verdad Luego compartidas cuantificación 192 1940 brasilidad, brasilidad , “brasilidad” población unitaria equivalencia 19 194 “brasilidad 1

Resumo Este artigo realiza uma abordagem cruzada de números e mapas de modo a evidenciar o poder performativo que emerge de suas interseções tecnopolíticas, como o conceito de densidade populacional e o recorte regional do território. Aplicada ao caso brasileiro, a análise combinada ilumina aspectos relativos à construção da autoridade do Estado e seu poder de criar categorias de pessoas e lugares. Para tanto, examinamos as tendências que aproximam a estatística da cartografia no Brasil Império e que indicam um estatuto comum a mapas e números enquanto instrumentos descritivos do poder soberano, como suas modalidades de uso, e suas condições de produção e validação da verdade. Na sequência, abordamos os fatores que levam à crescente importância dos números e dos mapas para a ação coletiva e para a produção de identidades compartilhadas. Com base nas referências da sociologia da quantificação, enfocamos a emergência da cartografia estatística e a crescente regionalização dos dados oficiais, entre as décadas de 1920 e 1940, ligadas a um novo modo de definir a brasilidade, ordenar o território e gerir a população. Concluímos que quantificar é também visualizar quantidades demográficas e econômicas em uma espacialidade coerente e unitária, uma vez estabilizada por convenções de equivalência. tecnopolíticas brasileiro lugares tanto soberano uso verdade sequência compartilhadas quantificação oficiais 192 1940 brasilidade população unitária equivalência 19 194 1

Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the brain, and inhibiting this enzyme can reduce oxidative stress, stabilize neurotransmitter levels, and alleviate symptoms. In this context, a pharmacophoric model was created using PharmaGist with 31 hits extracted from BindingDB to enable a pharmacophoric-based search of potential MAO-B inhibitors in ZincPharmer’s chemical space, followed by the building of 10 conformers for each molecule in the software OMEGA, screening for structural and electrostatic similarity to safinamide using ROCS (Rapid overlay of chemical structures) and EON (Electrostatic similarity for lead-hopping), respectively. In addition, the molecular docking with Gold using the score function was performed to rank the ligands with the highest probabilities of affinity to MAO-B and then discriminate those with suitable physical chemical, pharmacokinetic, and toxicological features using the tools QikProp, SwissADME, and DEREK. Four potential ligands with selective MAO-B inhibitor properties were identified, which show promise as future therapeutic agents for MAO-B-related disorders. Worldwide schizophrenia depression diseases MAOB MAO (MAO-B brain stress levels symptoms context 3 pharmacophoricbased based ZincPharmers ZincPharmer s space 1 OMEGA Rapid structures Electrostatic leadhopping, leadhopping lead hopping , lead-hopping) respectively addition pharmacokinetic QikProp SwissADME DEREK identified MAOBrelated related disorders lead-hopping

Chemometrics is gaining more and more space in universities and industry. To contribute to the development and expansion of principal component analysis (PCA) teaching proposals, this work evaluated the answers of the students to a questionnaire and presented a didactic-pedagogical proposal that can contribute to solving the principal doubts achieved by students in the PCA interpretation. Based on data collected in a semi-open questionnaire, the proposal was developed based on methodological principles of historical-critical pedagogy, containing the objectives, the problems surrounding the topic, and the cultural instruments necessary for understanding and interpreting PCA in the discipline of chemometrics by using new resources and instruments, especially free software, Chemostat. This proposal covers topics related to the concept of chemometrics and PCA, the explanation of the data set, pre-processing, use of Chemostat software, and analysis of principal components. It is hoped that this proposal can promote a better understanding concerning PCA on the part of students, as well as effective incorporation of the phenomena that involve this tool and its applications, and interpretation. Likewise, it is expected that this didactic-pedagogical proposal can support new teaching practices in chemometrics subjects in higher education. industry (PCA proposals didacticpedagogical didactic pedagogical interpretation semiopen semi open historicalcritical historical critical pedagogy objectives topic software set preprocessing, preprocessing pre processing, processing pre-processing components applications Likewise education

Abstract Purpose: To analyze the role of the community assembly as a determining instrument to exercise governance in local indigenous politics, because the various disputes between political factions erode the social fabric and increase the inequality gap. Methodological design: A qualitative, ethnographic study in the municipality of San Luis Amatlán, Oaxaca. Fifteen in-depth interviews were carried out with authorities throughout the municipality and with the adult population. The analysis was done with the analytical categories of governance in the Internal Regulatory Systems, in addition to the participants’ opinion on the performance of the municipal administrator. Results: It was found that the recovery of the municipal community assembly, as well as the assemblies in agencies and rancherías caused greater trust among the participants, together with an increase in the possibility of tracing a joint route to recover local governance through the election of the municipal council. Limitations of the study: Although the ethnographic approach sought to give voice to multiple community actors and social sectors, the research had a greater relationship with the authorities because they coexist more closely with the resource administration processes and their oversight. Findings: The community assembly is a fundamental element of the Internal Regulatory Systems which are consistent with the local customs and habits. The function of the assembly is not only to build consensus, it also acts as a means of control and administrative surveillance. Also, there is persistent conflict derived from the institutional design of indigenous municipalities, which have forms of resolution in their uses and customs such as the assembly, which is a space to address problems directly and without intermediaries.

Resumen Objetivo: Analizar el rol de la asamblea comunitaria como instrumento determinante para ejercer gobernanza en la política local indígena, ya que las diversas disputas entre facciones políticas erosionan el tejido social e incrementan la brecha de desigualdad. Diseño metodológico: Es de tipo cualitativo con una etnografía en el municipio de San Luis Amatlán, Oaxaca. Se realizaron 15 entrevistas a profundidad con autoridades en todo el municipio y con población adulta. El análisis se hizo con las categorías analíticas de gobernanza en los Sistemas Normativos Internos, además de la opinión sobre la figura de administrador municipal. Resultados: Se constató que la recuperación de la asamblea comunitaria municipal, así como las asambleas en agencias y rancherías, provocó mayor confianza entre las partes y la posibilidad de trazar una ruta conjunta para recobrar la gobernanza local a través de la elección del cabildo municipal. Limitaciones del estudio: Aunque la etnografía buscó dar voz a múltiples actores y sectores sociales comunitarios, la investigación tuvo mayor relación con las personas autoridades ya que éstas conviven con mayor cercanía con los procesos de administración de los recursos y su contraloría. Hallazgos: La asamblea comunitaria es un elemento fundamental en los Sistemas Normativos Internos, los cuales están insertos en los usos y costumbres indígenas y su función no sólo es construir consensos, sino que además actúa como medio de contraloría y vigilancia administrativa. También existe persistente conflictividad derivada del diseño institucional de los municipios indígenas, los cuales tienen formas de resolución en sus usos y costumbres como la asamblea, la cual es un espacio para abordar problemas de forma directa y sin intermediarios.

RESUMEN Esta investigación aborda la validez del espacio público como auspiciador de la participación política, centrándose en las diversas formas de apropiación del espacio que pueden fomentar dicha participación. El objetivo principal consiste en demostrar las posibilidades de acción política de las y los ciudadanos al expresar su desacuerdo a través de distintos procesos de apropiación del espacio público: la apropiación por dominación, por rebelión, la apropiación vandálica y artística. Se sostiene que la legitimidad de un sistema de gobierno puede cuestionarse o debilitarse según la actuación pública del cuerpo ciudadano contra el Estado o la entidad que ejerce la soberanía sobre el espacio. El análisis se llevará a cabo desde la filosofía política de la vertiente disociativa y el realismo político a través de los conceptos de conflicto, soberanía y desacuerdo.

ABSTRACT This research addresses the validity of public space as a promoter of political participation, focusing on the various forms of appropriation of space that can foster said participation. The main objective is to demonstrate the possibilities of political action of citizens by expressing their disagreement through different processes of appropriation of public space: appropriation by domination, appropriation by rebellion, vandalic, and artistic appropriation. It will be argued that the legitimacy of a government system can be questioned or weakened depending on the public actions of the citizen body against the State or the entity that exercises sovereignty over space. The analysis will be carried out from the political philosophy of the dissociative aspect and political realism, through the concepts of conflict, sovereignty, and disagreement.

Abstract Worker cooperatives in Argentina experienced an important boom at the beginning of the 21st century in response to the economic and social crises that affected the country. This situation entailed a restructuring of social and employment policies that emphasized work as a means of social inclusion. The aim of this article is to describe and characterize the type of labor insertion that worker cooperatives propose to their members in terms of income, formalization, benefits, and labor guarantees and the ways in which they organize production and time. The findings are presented of a descriptive study, based on the application of surveys and semi-structured interviews with members of 27 worker cooperatives in the Greater Santa Fe agglomerate, located in the Argentine pampas. The study, carried out between 2019 and 2020, recognizes the possibility of labor insertion offered by cooperatives to many people who have been excluded from the formal labor market and even of becoming a space for support, meeting, and training for members and associates. However, it describes nearly generalized situations of labor precariousness among people working in cooperatives, shaped by the lack of social protections and adequate economic regulation for associative and self-managed organizations.

Resumen Las cooperativas de trabajo en Argentina tuvieron un importante auge en los inicios del siglo XXI debido a las crisis económicas y sociales que afectaron al país. Esta situación supuso una reestructuración de la política social y de empleo que puso el énfasis en el trabajo como medio de inclusión social. El objetivo del presente artículo es describir y caracterizar el tipo de inserción laboral que las cooperativas de trabajo proponen a sus miembros en términos de ingresos, formalización, beneficios, garantías laborales y modos en que organizan la producción y los tiempos. Se presentan los hallazgos de una investigación descriptiva, basada en la aplicación de encuestas y entrevistas semiestructuradas a miembros de 27 cooperativas de trabajo del aglomerado Gran Santa Fe, ubicado en la pampa argentina. En el estudio, realizado entre los años 2019 y 2020, se reconoce la posibilidad de inserción laboral que ofrecen las cooperativas a muchas personas que han quedado excluidas del mercado de trabajo formal e incluso de convertirse en un espacio de contención, de encuentro y de formación para asociadas y asociados. Sin embargo, muestra situaciones de precariedad laboral de manera casi generalizada entre las personas que trabajan en las cooperativas, enmarcadas en la falta de condiciones de protección social y de regulación económica adecuadas para las organizaciones asociativas y autogestionadas.

Abstract Light wells in residential buildings represent a context that has received relatively little attention in daylighting analyses. This study aims to analyze the daylighting performance of a residential space with a window facing a light well, in order to contribute to the revision of NBR 15575:2013. The study conducted 1,152 daylighting analyses considering windows facing a light well, located on the first and fourth floors of a 4-story building. Clear and intermediate skies were considered in four Brazilian cities with different latitudes. Both the prescriptive method and point-in-time simulations were applied. The effectiveness of achieving daylit interior spaces through light wells strongly depends on the geometry of the light well and the external illuminance conditions of the city. Narrow light wells were found to be unsuitable for adequately daylighting the lower floor spaces. Furthermore, the prescriptive method was insufficient in representing daylighting originating solely from external wall interreflections. The study found that intermediate and superior performance levels, when achieved through point-in-time or spatial daylighting availability simulations, were never attained for the first-floor space. Therefore, the authors recommend that dense urban canyon situations and light wells be carefully considered in the revision of the standard. 155752013. 155752013 15575 2013. 2013 15575:2013 1152 1 152 1,15 4story story 4 building latitudes pointintime point time applied city Furthermore interreflections levels firstfloor Therefore standard 15575201 1557 201 15575:201 115 15 1,1 1557520 155 20 15575:20 11 1, 155752 2 15575:2 15575:

Resumo Poços de luz em edifícios residenciais representam um contexto com pouca atenção nas análises de iluminação natural. Esse estudo propõe analisar o desempenho de iluminação natural de um espaço residencial com janela voltada para poço de luz visando objetivo de contribuir com a revisão da NBR 15575:2013. O estudo realizou 1.152 análises de desempenho considerando a janela voltada para o poço de luz localizada no 1º e 4º pavimentos de uma edificação de quatro pavimentos. Foram considerados céu claros e intermediários em quatro cidades brasileiras com diferentes latitudes. O método prescritivo e simulação ponto-no-tempo foram aplicados. A solução de iluminação de espaços internos por meio de poços de luz depende fortemente de sua geometria e das condições de iluminância externa da cidade. Poços estreitos mostraram-se inaptos para levar luz suficiente para os ambientes inferiores. O método prescritivo não é capaz de representar adequadamente situações de iluminação natural oriunda exclusivamente de interreflexões de paredes externas. Os níveis intermediários e superiores de desempenho por simulação ponto-no-tempo ou por análises baseadas no clima não foram atendidos no 1º pavimento. Os autores recomendam que situações de cânions urbanos densos e poços de luz sejam cuidadosamente consideradas na análise da revisão da norma. 155752013. 155752013 15575 2013. 2013 15575:2013 1152 1 152 1.15 º latitudes pontonotempo ponto tempo aplicados cidade mostraramse mostraram se inferiores externas pavimento norma 15575201 1557 201 15575:201 115 15 1.1 1557520 155 20 15575:20 11 1. 155752 2 15575:2 15575:

ABSTRACT Introduction: We aim to compare the safety and effectiveness of the KangDuo (KD)-Surgical Robot-01 (KD-SR-01) system and the da Vinci (DV) system for robot-assisted radical nephroureterectomy (RARNU). Materials and Methods: This multicenter prospective randomized controlled trial was conducted between March 2022 and September 2023. Group 1 included 29 patients undergoing KD-RARNU. Group 2 included 29 patients undergoing DV-RARNU. Patient demographic and clinical characteristics, perioperative data, and follow-up outcomes were collected prospectively and compared between the two groups. Results: There were no significant differences in patient baseline demographic and preoperative characteristics between the two groups. The success rates in both groups were 100% without conversion to open or laparoscopic surgery or positive surgical margins. No significant difference was observed in docking time [242 (120-951) s vs 253 (62-498) s, P = 0.780], console time [137 (55-290) min vs 105 (62-220) min, P = 0.114], operative time [207 (121-460) min vs 185 (96-305) min, P = 0.091], EBL [50 (10-600) mL vs 50 (10-700) mL, P = 0.507], National Aeronautics and Space Administration Task Load Index scores, and postoperative serum creatinine levels between the two groups. None of the patients showed evidence of distant metastasis, local recurrence, or equipment-related adverse events during the four-week follow-up. One (3.4%) patient in Group 2 experienced postoperative enterovaginal and enterovesical fistulas (Clavien-Dindo grade III). Conclusions: The KD-SR-01 system is safe and effective for RARNU compared to the DV Si or Xi system. Further randomized controlled studies with larger sample sizes and longer durations are required. Introduction KDSurgical KD Surgical Robot01 Robot 01 Robot-0 KDSR01 KDSR SR (KD-SR-01 (DV robotassisted robot assisted RARNU. . (RARNU) Methods 202 2023 KDRARNU. KDRARNU KD-RARNU DVRARNU. DVRARNU DV-RARNU data followup follow up Results 100 margins 242 [24 120951 120 951 (120-951 25 62498 62 498 (62-498 0.780, 0780 0.780 , 0 780 0.780] 137 [13 55290 55 290 (55-290 10 62220 220 (62-220 0.114, 0114 0.114 114 0.114] 207 [20 121460 121 460 (121-460 18 96305 96 305 (96-305 0.091, 0091 0.091 091 0.091] [5 10600 600 (10-600 5 10700 700 (10-700 0.507, 0507 0.507 507 0.507] scores metastasis recurrence equipmentrelated equipment related fourweek four week followup. up. 3.4% 34 3 4 (3.4% ClavienDindo Clavien Dindo III. III III) Conclusions KD-SR-0 required Robot0 Robot- KDSR0 (KD-SR-0 (RARNU 20 24 [2 12095 12 95 (120-95 6249 6 49 (62-49 078 0.78 78 13 [1 5529 (55-29 6222 22 (62-22 011 0.11 11 12146 46 (121-46 9630 9 30 (96-30 009 0.09 09 [ 1060 60 (10-60 1070 70 (10-70 050 0.50 3.4 (3.4 KD-SR- (KD-SR- 1209 (120-9 624 (62-4 07 0.7 7 552 (55-2 622 (62-2 0.1 1214 (121-4 963 (96-3 00 0.0 106 (10-6 107 (10-7 05 0.5 3. (3. KD-SR (KD-SR (120- (62- 0. (55- (121- (96- (10- (3 (120 (62 (55 (121 (96 (10 ( (12 (6 (5 (9 (1

ABSTRACT Introduction: The introduction of Single-Port (SP) platform opened the field to new surgical options, allowing to perform major urological robot-assisted procedures extraperitoneally and with a supine patient positioning (1–3). Nevertheless, a comprehensive description of different supine access options is still lacking (4–6). In this light, we provided a step-by-step guide of SP extraperitoneal supine access options also exploring preliminary surgical outcomes. Materials and methods: Transvesical access was performed by a transversal incision 3cm above the pubic bone, after the anterior abdominal sheet incision, the bladder was insufflated with a flexible cystoscope and the detrusor muscle was incised at the level of the bladder dome. Similarly, the extraperitoneal access was carried out with a 4cm incision above the pubic bone, once visualized the preperitoneal space the prevesical fat was gently spread. The Low Anterior Access was performed with a 3cm incision at the McBurney point, the abdominal muscles were then spread. A gentle dissection was used laterally to develop the retroperitoneal space. Results: Overall, sixteen different procedures were performed with supine extraperitoneal access on 623 consecutive patients. No intraoperative conversions occurred. The median access time was 16 (IQR 12-21), 11 (IQR 7-14) and 14 (IQR 10-18) minutes in case of transvesical, extraperitoneal and low anterior access, respectively. Notably, 81.5 % of patients were discharged on the same day with a postoperative opioid free rate of 73%. Conclusion: The Atlas provides a comprehensive step-by-step guide to successfully perform all major urological SP procedures extraperitoneally and with supine patient positioning. Introduction SinglePort Single Port (SP robotassisted robot assisted 1–3. 13 1–3 . 1 3 (1–3) Nevertheless 4–6. 46 4–6 4 6 (4–6) light stepbystep step outcomes methods cm bone dome Similarly spread point Results Overall 62 occurred IQR 1221, 1221 12 21 , 12-21) 714 7 7-14 1018 10 18 10-18 transvesical respectively Notably 815 81 5 81. 73 73% Conclusion 1– (1–3 4– (4–6 122 2 12-21 71 7-1 101 10-1 8 (1– (4– 12-2 7- 10- (1 (4 12- (

Abstract Research which evaluates Social Housing (SH) in Brazil often points out unfavorable conditions expressed by residents, in terms of the residential unit and common spaces, as well as surroundings. Participatory processes to improve projects are considered essential for political, social and economic reasons, and user values need to be prioritized. Processes to develop improvements for existing SH, that include residents as protagonists, with active participation, may guide more effective actions. However, participatory processes for home and public area renovations require procedures to effectively achieve their technical objectives and meet the needs and desires of their residents with feasibility of implementation. This research developed a case study with the participation of residents of a small SH project in Campinas - SP, with a specific focus on improvements for the children's leisure areas. The study involved the public targeted, children living in the analyzed SH complex, in defining their leisure space through dynamics and playful activities. Qualitative results are presented of this participatory process, involving children. Knowledge gained is methodological, with lessons learned for the planning and development of participatory co-design projects with children. (SH spaces surroundings political reasons prioritized protagonists actions However implementation SP childrens s areas targeted complex activities process methodological codesign co design

Resumo Pesquisas que avaliam Habitação de Interesse Social (HIS) no Brasil em geral apontam condições desfavoráveis expressas pelos moradores em relação à sua moradia, em termos de unidade habitacional e espaços comuns, assim como seu entorno. Processos participativos para melhorias são considerados essenciais por razões políticas, sociais e econômicas, priorizando os valores do usuário. Considera-se que o desenvolvimento de processos de introdução de melhorias de HIS existentes, no qual o morador é protagonista,participando ativamente, pode orientar ações efetivas. No entanto, processos participativos com foco em melhorias residenciais e em áreas comuns necessitam de procedimentos que de fato atinjam objetivos técnicos e atendam as necessidades e desejos dos moradores, priorizando a viabilidade de execução. A pesquisa desenvolveu um estudo de caso com participação de moradores de um conjunto habitacional em Campinas, SP, com foco específico na área recreativa de uso infantil. O estudo envolveu o público-alvo, crianças moradoras do conjunto habitacional, na definição do seu espaço de lazer, a partir de dinâmicas e atividades lúdicas. São apresentados resultados qualitativos deste processo participativo, envolvendo as crianças. O conhecimento adquirido é metodológico, com lições aprendidas para o planejamento e desenvolvimento de projetosparticipativos de co-design com crianças. (HIS moradia entorno políticas econômicas usuário Considerase Considera se existentes protagonistaparticipando protagonista participando ativamente efetivas entanto execução Campinas SP infantil públicoalvo, públicoalvo público alvo, alvo público-alvo lazer lúdicas participativo metodológico codesign co design

Resumé Le télétravail à domicile a atteint 11% de la population occupée du pays dans le contexte de la pandémie de COVID-19. Il s'agissait en majorité de femmes, de personnes blanches, diplômées de l'enseignement supérieur, et travaillant dans les secteurs des services et de la communication. La réalité des télétravailleurs à domicile est différente de celle de la plupart des travailleurs à domicile d'avant la pandémie: femmes noires, peu scolarisées et travaillant dans l'industrie manufacturière. Cependant, en examinant les données du PNAD entre 1992 et 2019, on peut observer la croissance, dans ce type de travail, de la participation des hommes ayant une formation et une rémunération supérieures et travaillant dans les secteurs des services et de la communication. En ce sens, bien que le travail à domicile ait peu varié dans le période, certaines tendances d'évolution de ce type de travail se dégagent des données, réalisées à domicile et sur le profil du travailleur à domicile. Nous comprenons que ces changements observés dans la pré pandémie contribuent à comprendre l'espace que le télétravail à domicile a gagné dans la pandémie, à se renforcer comme modalité de travail et à se justifier comme alternative pour organiser l'espace de travail. 11 COVID19. COVID19 COVID 19. 19 COVID-19 sagissait s agissait blanches lenseignement l enseignement supérieur communication davant d avant noires lindustrie industrie manufacturière Cependant 199 2019 croissance sens période dévolution évolution lespace espace 1 COVID1 COVID-1 201 COVID- 20 2

Resumo O trabalho remoto atingiu 11% da população ocupada do Brasil no contexto da pandemia da COVID-19: uma maioria de mulheres, pessoas brancas, com nível superior de escolaridade, e atuantes no setor de educação e serviços. Esse perfil é distinto do padrão predominante de trabalhadores em domicílio: mulheres negras com baixo nível de escolaridade e atuantes na indústria de transformação. Mas, ao revisar os dados da PNAD entre 1992 e 2019, encontramos algumas transformações nos setores da economia e atividades ocupacionais realizados em domicílio, bem como uma mudança no perfil do trabalhador em domicílio: crescimento na participação de homens com maior nível de escolaridade e remuneração e atuantes no setor de serviços e de comunicação. Defendemos, neste artigo, que essas mudanças no trabalho em domicílio observadas na pré-pandemia contribuem para compreender o espaço que o trabalho remoto ganhou durante e após a pandemia para se fortalecer enquanto modalidade de trabalho e se justificar enquanto alternativa de organização de espaço de trabalho. 11 COVID19 COVID 19 COVID-19 brancas transformação Mas 199 2019 comunicação Defendemos artigo prépandemia pré 1 COVID1 COVID-1 201 COVID- 20 2

Abstract Remote work reached 11% of Brazil's employed population in the context of the COVID-19 pandemic: the majority being women, white individuals with higher education levels, and working in the education and services sectors. This profile is distinct from the predominant pattern of home-based workers: black women with lower education levels and working in the manufacturing industry. However, upon reviewing PNAD data from 1992 to 2019, we found some transformations in home-based economic sectors and occupational activities. Additionally, there has been a shift in the profile of home-based workers: an increase in the participation of men with higher education and income levels, working in the services and communication sectors. In this article, we argue that these pre-pandemic changes in home-based work contribute to understanding the space that remote work has gained during and after the pandemic to strengthen itself as a work modality and justify itself as an alternative for organizing workspaces. 11 Brazils Brazil s COVID19 COVID 19 COVID-1 homebased home based workers industry However 199 2019 activities Additionally article prepandemic pre workspaces 1 COVID1 COVID- 201 20 2

Abstract: Healthcare buildings can be complicated to navigate, causing patients to experience stress and lose time if not adequately planned. This study aims to identify the relationship between the spatial layout in healthcare buildings and wayfinding for users, by utilizing Behavioral Sequence Analysis (BSA) and Space Syntax through Immersive Virtual Reality (iVR). The methodology is based on behavioral and spatial data and was tested by using the experimental setups in VR environments. Space syntax analysis is applied to collect spatial data. Experiments were conducted by assigning wayfinding tasks in virtual hospitals with various plan configurations. Behavioral data obtained from BSA was associated with the spatial data driven by the space syntax analysis to gain a comprehensive understanding of the participants' wayfinding behavior. The results indicate that the semi-centralized floor plan layout with high visibility levels performs better in wayfinding while the decentralized layout with low visibility values performs worse.

Resumen: Los edificios de atención médica pueden ser complicados de navegar, causando estrés y pérdida de tiempo a los pacientes si no están planificados adecuadamente. Este estudio busca identificar la relación entre la disposición espacial en estos edificios y la orientación de los usuarios, utilizando Análisis de Secuencia Comportamental (BSA) y Sintaxis Espacial a través de Realidad Virtual Inmersiva (iVR). La metodología se basa en datos comportamentales y espaciales, probada en configuraciones experimentales en entornos de iRV. El análisis de sintaxis espacial se emplea para recopilar datos. Se realizaron experimentos con tareas de orientación en hospitales virtuales con diversas configuraciones de plano. Los datos conductuales del BSA se asociaron con los datos espaciales, obteniendo una comprensión completa del comportamiento de orientación. Los resultados indican que la disposición semi-centralizada con alta visibilidad es más eficaz en la orientación, mientras que la distribución descentralizada con baja visibilidad lo es menos.

Abstract: Some terms such as "neighbourhood," "doorstep philosophy," or "space between" hold special significance in the work of Alison and Peter Smithson. Especially the latter is a recurrent term in their writings and works. Exploring the origin of their interest in this concept, the influence of Nigel Henderson, and its impact on Team X, as well as their considerations on the quality of the intermediate space based on the paintings of Pieter de Hooch, is the main objective of this writing. It is thus proposed to delve into some approaches that invite to unravel the concept: through emptiness, the sky, strata and frameworks, trees, we can observe how the space between enriches the architecture of the Smithsons to attend to each person and place in a precise way and, thus, offer responses to the specific; an approach that is ultimately at the origin of all their reflections.

Resumen: Algunos términos como neighbourhood, doorstep philosophy o space between, cobran especial importancia en la obra de Alison y Peter Smithson. Especialmente el último es un término recurrente en sus escritos y trabajos. Explorar el origen de su interés por este concepto, la influencia de Nigel Henderson y su repercusión en el Team X, así como sus consideraciones sobre la cualidad del espacio intermedio a partir de las pinturas de Pieter de Hoch, es el objetivo principal de este escrito. Se propone así ahondar en algunas aproximaciones que invitan a desentrañar el concepto: a través del vacío, del cielo, de los estratos y entramados, de los árboles, podemos observar como el space between enriquece la arquitectura de los Smithson para atender a cada persona y lugar de forma precisa y, de esta manera, ofrecer respuestas a lo específico; un planteamiento que está, en definitiva, en el origen de todas sus reflexiones.