Methods used to determine pesticide residues in teas typically require several laborious steps for sample preparation before analysis. In this study, a simple method based on solid-liquid extraction with low-temperature partitioning (SLE/LTP) and analysis by gas chromatography coupled to mass spectrometry (GC-MS) was optimized and validated for the determination of pesticide residues (pirimiphos-methyl, flutriafol, cyproconazole, and bifenthrin) in dehydrated green tea leaves. After low-temperature partitioning (LTP), the extract in acetonitrile was subjected to a clean-up step using primary secondary amine (PSA) and octadecylsilane (C18) as sorbents for chlorophyll removal. The optimized SLE/LTP-GC-MS method was validated, and it proved to be effective and selective for extracting pesticides from green tea samples, presenting limit of detection (LOD) and limit of quantification (LOQ) of 0.015 and 0.050 mg kg-1, respectively. Recovery ranged between 81-111%, coefficients of variation were less than 16% and coefficients of determination (R2) were greater than 0.990. The optimized and validated method was applied to green tea and 13 other tea varieties sampled in South and Southeast regions of Brazil. The pesticides under study were detected in some of those samples at values higher than the maximum residue limits (MRLs) allowed by the European Union. solidliquid solid liquid lowtemperature low temperature SLE/LTP SLELTP SLE LTP (SLE/LTP GCMS GC MS (GC-MS pirimiphosmethyl, pirimiphosmethyl pirimiphos methyl, methyl (pirimiphos-methyl flutriafol cyproconazole bifenthrin leaves LTP, , (LTP) cleanup clean up PSA (PSA C18 C (C18 removal SLE/LTPGCMS SLELTPGCMS LOD (LOD LOQ (LOQ 0015 0 015 0.01 0050 050 0.05 kg1, kg1 kg 1, 1 kg-1 respectively 81111%, 81111 81 111%, 111 81-111% 16 R2 R (R2 0990 990 0.990 Brazil MRLs (MRLs Union (LTP C1 (C1 LTPGCMS 001 01 0.0 005 05 kg- 81111% 8111 8 111% 11 81-111 (R 099 99 0.99 (C 00 0. 811 81-11 09 9 0.9 81-1 81-

ABSTRACT Purpose: To describe the epidemiological and clinical profile of hospitalized patients with retinoblastoma in Brazil. Methods: Using data from the Hospital Cancer Registry of the Instituto Nacional de Câncer, patients with the morphological codes of retinoblastoma who were diagnosed between 2000 to 2018, aged 0–19 years, and followed up in registered hospitals (analytical cases) were selected. The relative and absolute frequencies of demographic, clinical, diagnostic, therapeutic, and outcome variables were described. Hospital performance indicators were calculated and compared between hospitals qualified and not qualified to treat pediatric oncology cases and between hospitals with different case volumes (<20, 20-75, >75 cases). Results: Of the 2,269 identified analytical cases from 86 institutions, 48% were from the Southeast, 54% were male, and 66% were aged <4 years. The proportion of missing data (NA) was too high for several variables. Approximately 84% of the patients were from the public health system, 40% had a positive family history, and 88% had unilateral involvement. The first treatment included surgery in 58.3% of the patients (NA=2), Approximately 36.6% of these patients achieved complete remission, 10.8% achieved partial remission, and 12.7% died (NA=59%). Hospital performance indicators were within the target in >90% of the patients. The median time between the first appointment and diagnosis (6 days, interquartile range [IQR] 1–14) was significantly lower and the median time to death was longer (343 days, IQR, 212-539) in high-volume hospitals (>75 cases) than in medium- and low-volume hospitals. Conclusions: Despite the high proportion of missing data, we found that the delay in diagnosis is due to prehospital factors. Additionally, there is a need for educational programs for healthcare professionals and families that emphasize early identification and referral to specialized centers. Future studies should focus on the impact of Hospital Cancer Registry data completeness on outcomes, causes of delay in diagnosis, regional inequalities, and barriers to accessing specialized services. Purpose Brazil Methods Câncer 200 2018 019 0 19 0–1 years selected demographic diagnostic therapeutic described <20, 20 (<20 2075, 2075 75, 75 20-75 >7 cases. . Results 2269 2 269 2,26 8 institutions 48 Southeast 54 male 66 4 < NA (NA 84 system 40 history 88 involvement 583 58 3 58.3 NA=2, NA2 NA=2 , (NA=2) 366 36 6 36.6 remission 108 10 10.8 127 12 7 12.7 NA=59%. NA59 NA=59% 59 (NA=59%) 90 >90 ( days IQR [IQR 1–14 114 1 14 343 (34 212539 212 539 212-539 highvolume volume (>7 medium lowvolume low Conclusions factors Additionally centers outcomes inequalities services 201 01 0– <20 (<2 207 20-7 > 226 26 2,2 5 58. NA= (NA=2 36. 10. 12. NA5 NA=59 (NA=59% 9 >9 1–1 11 34 (3 21253 21 53 212-53 (> <2 (< 20- 22 2, (NA= NA=5 (NA=59 1– 2125 212-5 (NA=5 212-

RESUMO Objetivo: Avaliar a sazonalidade da bronquiolite aguda no Brasil durante a temporada 2020–2022 e compará-la com a das temporadas anteriores. Métodos: Os dados de incidência de internações por bronquiolite aguda em lactentes <1 ano de idade foram obtidos do Departamento de Informática da base de dados da Saúde Pública Brasileira para o período entre 2016 e 2022. Esses dados também foram analisados por macrorregiões do Brasil (Norte, Nordeste, Sudeste, Sul e Centro-Oeste). Para descrever características sazonais e de tendência ao longo do tempo, utilizamos o Modelo de Médias Móveis Integradas Autorregressivas Sazonais. Resultados: Em comparação com o período pré-COVID-19, a incidência de hospitalizações relacionadas com bronquiolite aguda diminuiu 97% durante as intervenções não farmacológicas (março de 2020 – agosto de 2021), mas aumentou 95% após a flexibilização das intervenções não farmacológicas (setembro de 2021 – dezembro de 2022), resultando no aumento geral de 16%. Durante o período pré-COVID-19, as hospitalizações por bronquiolite aguda seguiram um padrão sazonal, que foi interrompido em 2020–2021, mas recuperaram-se em 2022, com um pico ocorrido em maio, aproximadamente 4% superior ao pico pré-COVID-19. Conclusões: Este estudo ressalta a influência significativa das intervenções contra a COVID-19 nas hospitalizações por bronquiolite aguda no Brasil. A restauração de um padrão sazonal em 2022 sublinha a interação entre as medidas de saúde pública e a dinâmica das doenças respiratórias em crianças pequenas. Objetivo 20202022 2020–202 comparála compará la anteriores Métodos 1 < 201 Norte, Norte (Norte Nordeste Sudeste CentroOeste. CentroOeste Centro Oeste . Centro-Oeste) tempo Sazonais Resultados préCOVID19, préCOVID19 préCOVID pré COVID 19, 19 pré-COVID-19 97 março 202 2021, , 2021) 95 setembro 2022) 16 16% 20202021 2020–2021 recuperaramse recuperaram se maio 4 préCOVID19. 19. Conclusões COVID19 COVID-1 pequenas 2020202 2020–20 20 Centro-Oeste préCOVID1 pré-COVID-1 9 COVID1 COVID- 202020 2020–2 2 pré-COVID- 20202 2020– pré-COVID

ABSTRACT Objective: To evaluate the seasonality of acute bronchiolitis in Brazil during the 2020–2022 season and compare it with the previous seasons. Methods: Data from the incidence of hospitalizations due to acute bronchiolitis in infants <1 year of age were obtained from the Department of Informatics of the Brazilian Public Health database for the period between 2016 and 2022. These data were also analyzed by macro-regions of Brazil (North, Northeast, Southeast, South, and Midwest). To describe seasonal and trend characteristics over time, we used the Seasonal Autoregressive Integrated Moving Averages Model. Results: Compared to the pre-COVID-19 period, the incidence of hospitalizations related to acute bronchiolitis decreased by 97% during non-pharmacological interventions (March 2020 – August 2021) but increased by 95% after non-pharmacological interventions relaxation (September 2021 – December 2022), resulting in a 16% overall increase. During the pre-COVID-19 period, hospitalizations for acute bronchiolitis followed a seasonal pattern, which was disrupted in 2020–2021 but recovered in 2022, with a peak occurring in May, approximately 4% higher than the pre-COVID-19 peak. Conclusions: This study underscores the significant influence of COVID-19 interventions on acute bronchiolitis hospitalizations in Brazil. The restoration of a seasonal pattern in 2022 highlights the interplay between public health measures and respiratory illness dynamics in young children. Objective 20202022 2020–202 seasons Methods 1 < 201 macroregions macro regions North, North (North Northeast Southeast South Midwest. Midwest . Midwest) time Model Results preCOVID19 preCOVID pre COVID 19 pre-COVID-1 97 nonpharmacological non pharmacological March 202 95 September , 2022) 16 increase 20202021 May 4 Conclusions COVID19 COVID-1 children 2020202 2020–20 20 preCOVID1 pre-COVID- 9 COVID1 COVID- 202020 2020–2 2 pre-COVID 20202 2020–

Abstract Objectives To investigate the associations between caregivers’ burden, family quality of life (QoL), and siblings’ QoL in Brazilian families of children with cerebral palsy, and to analyze siblings’ QoL using as a parameter the QoL of typically developed Brazilian children. Methods It was a cross-sectional study. The 212 families, 212 caregivers and 131 siblings completed the Family Quality of Life Scale, Burden Interview, and KIDSCREEN-27 Child and Adolescent Version and Parents Version questionnaires at a neurorehabilitation center in southeast Brazil. Univariable and multivariable models were used. Results Family QoL significantly worsened as caregivers’ burden increased (95 % CI -0.66 to -0.38). Caregivers’ burden was significantly lower with increasing family QoL scores (95 % CI -0.52 to -0.30). Self-reported siblings’ QoL was significantly worse than that of their typically developed peers (95 % CI -7.6 to -3.6). Self-reported siblings’ QoL was significantly lower as siblings’ age (95 % CI -2.52 to -0.59) and caregivers’ burden (95 % CI -0.35 to -0.05) increased. Parent-reported siblings’ QoL was significantly lower with increasing caregivers’ burden (95 % CI -0.45 to -0.16) and higher as family QoL increased (95 % CI 0.09 to 0.37). Conclusions The cross-sectional nature of these data precludes any statement of causality. Family QoL worsened with higher caregivers’ burden levels. Lower caregivers’ burden scores were associated with a higher family QoL. Siblings’ QoL was impaired as compared to typically developed peers, worse among older siblings, and as caregivers’ burden increased and better with higher family QoL levels. Future multicenter studies may validate the generalizability of the present findings. QoL, , (QoL) palsy crosssectional cross sectional study 21 13 Scale Interview KIDSCREEN27 KIDSCREEN 27 KIDSCREEN-2 Brazil used 95 (9 0.66 066 0 66 -0.6 0.38. 038 0.38 . 38 -0.38) Caregivers 0.52 052 52 -0.5 0.30. 030 0.30 30 -0.30) Selfreported Self reported 7.6 76 7 6 -7. 3.6. 36 3.6 3 -3.6) 2.52 252 2 -2.5 0.59 059 59 -0.59 0.35 035 35 -0.3 0.05 005 05 -0.05 Parentreported Parent 0.45 045 45 -0.4 0.16 016 16 -0.16 009 09 0.0 0.37. 037 0.37 37 0.37) causality levels Siblings findings (QoL 1 KIDSCREEN2 KIDSCREEN- 9 ( 0.6 06 -0. 03 0.3 -0.38 0.5 5 -0.30 7. -7 3. -3.6 2.5 25 -2. 00 -0.0 0.4 04 4 0.1 01 -0.1 0. -0 - -3. 2. -2 -3

Resumo O estudo analisou a distribuição espacial e as desigualdades sociais na cobertura vacinal para COVID-19 entre crianças de 5 a 11 anos no Brasil. As coberturas vacinais foram calculadas para os municípios brasileiros e analisadas por região geográfica e decis com base no Índice de Desenvolvimento Humano (IDH-M) e expectativa de escolaridade aos 18 anos. Modelos multiníveis foram usados para determinar o coeficiente de partição da variância, e a estatística local bivariada de Moran I foi usada para avaliar a associação espacial. Os resultados mostraram diferenças significativas nas taxas de cobertura vacinal entre os municípios, com menor cobertura nas regiões Norte e Centro-Oeste. Municípios com menor IDH e anos de escolaridade esperados apresentaram menores taxas de cobertura vacinal. A análise de agrupamento bivariado identificou extensas concentrações de municípios nas regiões Norte e Nordeste com baixa cobertura vacinal e baixo desenvolvimento humano, enquanto alguns aglomerados de municípios nas regiões Sudeste e Sul com baixa cobertura localizavam-se em áreas com alto IDH-M. Essas descobertas destacam as desigualdades persistentes em nível municipal na cobertura vacinal entre crianças e a necessidade de intervenções para melhorar o acesso e a cobertura vacinal em áreas mais vulneráveis. COVID19 COVID 19 COVID-1 1 Brasil IDHM M (IDH-M variância CentroOeste. CentroOeste Centro Oeste. Oeste Centro-Oeste humano localizavamse localizavam se IDHM. M. IDH-M vulneráveis COVID1 COVID-

Abstract This study examined the spatial distribution and social inequalities in COVID-19 vaccine coverage among children aged 5-11 in Brazil. First and second dose vaccine coverage was calculated for all Brazilian municipalities and analyzed by geographic region and deciles based on human development index (HDI-M) and expected years of schooling at 18 years of age. Multilevel models were used to determine the variance partition coefficient, and bivariate local Moran’s I statistic was used to assess spatial association. Results showed significant differences in vaccine coverage rates among Brazilian municipalities, with lower coverage in the North and Midwest regions. Municipalities with lower HDI and expected years of schooling had consistently lower vaccine coverage rates. Bivariate clustering analysis identified extensive concentrations of municipalities in the Northern and Northeastern regions with low vaccine coverage and low human development, while some clusters of municipalities in the Southeast and South regions with low coverage were located in areas with high HDI-M. These findings highlight the persistent municipal-level inequalities in vaccine coverage among children in Brazil and the need for targeted interventions to improve vaccine access and coverage in underserved areas. COVID19 COVID 19 COVID-1 511 5 11 5-1 HDIM M (HDI-M 1 age coefficient Morans Moran s association HDIM. M. HDI-M municipallevel municipal level COVID1 COVID- 51 5-

Abstract This study seeks to point out the different configurations of Health Care Networks in primary care (AB) and Hospital Care (AH), dimensioned based on coverage, quality, and resolvability characteristics in health macro-regions. Cross-sectional study used the cluster analysis and segmented 103 macro-regions into different profiles of coverage, quality and resolubility: group 1 (high coverage/AB and medium/AH; low quality AB-AH with high resolubility); group 2 (high coverage/AB and low/AH; low quality AB-AH with medium resolubility) and group 3 (high coverage/AB and medium/AH; high quality AB-AH with high resolubility). Coverage in AB was classified as high for 100% of the Brazilian population and in AH low to 9.70% and medium to 90.29%. Quality/AB-AH is low for 58.54% and high for 41.15%. Resolubility is high for 90.29% and medium for 9.70%. In Brazil, there is expansion of coverage with low quality/AB; shortage of hospital beds and low quality/HA with high resolution. However, in the Southeast and South, high AB-AH quality prevails. The structuring of health networks is still characterized by low resolution, demanding incentives for the governance of inter-federal arrangements. (AB AH, , (AH) macroregions. macroregions macro regions. regions Crosssectional Cross sectional 10 resolubility coverageAB medium/AH mediumAH ABAH low/AH lowAH resolubility. . 100 970 9 70 9.70 9029 90 29 Quality/ABAH QualityABAH Quality/AB Quality 5854 58 54 58.54 4115 41 15 41.15% 90.29 Brazil quality/AB qualityAB qualityHA HA resolution However South prevails interfederal inter federal arrangements (AH 97 7 9.7 902 QualityAB 585 5 58.5 411 4 41.15 90.2 9. 58. 41.1 90. 41.

Resumo O estudo procura apontar diferentes configurações de Redes de Atenção à Saúde na atenção básica e hospitalar, a partir de características de cobertura, qualidade e resolubilidade nas macrorregiões de saúde. Estudo transversal, utilizou a técnica de análise de cluster e segmentou 103 macrorregiões em distintos perfis de cobertura, qualidade e resolubilidade: grupo 1 (alta cobertura/AB e média/AH; baixa qualidade AB-AH com alta resolubilidade); grupo 2 (alta cobertura/AB e baixa/AH; baixa qualidade AB-AH com média resolubilidade); e o grupo 3 (alta cobertura/AB e média/AH; alta qualidade AB-AH com alta resolubilidade). A cobertura na AB foi classificada como alta para 100% da população brasileira, e na AH, baixa para 9,70% e média para 90,29%. Qualidade/AB-AH é baixa para 58,54% e alta para 41,15%. A resolubilidade é alta para 90,29% e média para 9,70%. No Brasil, verifica-se expansão da cobertura com baixa qualidade/AB, insuficiência de leitos hospitalares e baixa qualidade/AH com alta resolubilidade. Todavia, prevalece alta qualidade AB-AH no Sudeste e no Sul. A estruturação das redes de saúde ainda se configura de baixa resolutividade, demandando estímulos à governança de arranjos interfederativos. hospitalar transversal 10 coberturaAB média/AH médiaAH AH ABAH resolubilidade) baixa/AH baixaAH . 100 brasileira 970 9 70 9,70 9029 90 29 Qualidade/ABAH QualidadeABAH Qualidade/AB Qualidade 5854 58 54 58,54 4115 41 15 41,15% 90,29 Brasil verificase verifica qualidadeAB qualidade/AB qualidadeAH Todavia Sul resolutividade interfederativos 97 7 9,7 902 QualidadeAB 585 5 58,5 411 4 41,15 90,2 9, 58, 41,1 90, 41,

Abstract Objective: To analyze the prevalence evolution of Guthrie, hearing, and eye screening testing among newborns in Brazil, between 2013 and 2019, according to demographic and socioeconomic characteristics. Methods: This is a cross-sectional study with data from 5231 infants from the Pesquisa Nacional de Saude (PNS), in 2013, and 6637 infants, in 2019, for the Guthrie test, hearing, and red reflex tests. The authors analyzed the outcomes according to the region of residence, self-reported color/race, having health insurance, and per capita household income. By using bivariate and multivariate Poisson regression models, the prevalence ratios and their respective 95 % Confidence Intervals (CI95%) were calculated for each year. Results: In 2013, Guthrie test, hearing, and red reflex tests were performed in 96.5 % (95%CI 95,8;97,0), 65.8 % (95%CI 63,9;67,7), and 60.4 % (95%CI 58,5;62,3) of infants, respectively. In 2019, the prevalence was 97.8 % (95%CI 97,3;98,2) in the Guthrie test, 81.6 % (95%CI 80,3;82,9) in the hearing test, and 78.6 % (95%CI 77,1;79,9) in the red reflex test. The testing frequency was higher among residents of the Southeast and South regions of Brazil, among infants whose mother or guardian was white, had health insurance, and was in the higher income strata; and the most evident differences were in the eye and hearing testing. Conclusions: The coverage inequalities according to the region of residence, income, and having health insurance highlight the need to use strategies that enable exams to be carried out, with more information about their importance, encompassing actions from primary care, prenatal care to the puerperium, aiming at universal access and equity. Objective Brazil 201 2019 characteristics Methods crosssectional cross sectional 523 PNS, PNS , (PNS) 663 test residence selfreported self reported colorrace color race color/race models 9 CI95% CI95 CI (CI95% year Results 965 96 5 96. 95%CI 95CI 95,897,0, 958970 95,8 97,0 8 97 0 95,8;97,0) 658 65 65. 63,967,7, 639677 63,9 67,7 63 67 7 63,9;67,7) 604 60 4 60. 58,562,3 585623 58,5 62,3 58 62 3 58,5;62,3 respectively 978 97. 97,398,2 973982 97,3 98,2 98 2 97,3;98,2 816 81 6 81. 80,382,9 803829 80,3 82,9 80 82 80,3;82,9 786 78 78. 77,179,9 771799 77,1 79,9 77 1 79 77,1;79,9 white strata Conclusions out importance puerperium equity 20 52 (PNS 66 CI9 (CI95 897 95,897,0 95897 958 95, 970 97, 95,8;97,0 967 63,967,7 63967 639 63, 677 67, 63,9;67,7 562 58,562, 58562 585 58, 623 62, 58,5;62, 398 97,398, 97398 973 982 98, 97,3;98, 382 80,382, 80382 803 80, 829 82, 80,3;82, 179 77,179, 77179 771 77, 799 79, 77,1;79, (CI9 89 95,897, 9589 95,8;97, 63,967, 6396 63,9;67, 56 58,562 5856 58,5;62 39 97,398 9739 97,3;98 38 80,382 8038 80,3;82 17 77,179 7717 77,1;79 (CI 95,897 95,8;97 63,967 63,9;67 58,56 58,5;6 97,39 97,3;9 80,38 80,3;8 77,17 77,1;7 95,89 95,8;9 63,96 63,9;6 58,5; 97,3; 80,3; 77,1; 95,8; 63,9;

Resumo O estudo procura apontar diferentes configurações de Redes de Atenção à Saúde na atenção básica e hospitalar, a partir de características de cobertura, qualidade e resolubilidade nas macrorregiões de saúde. Estudo transversal, utilizou a técnica de análise de cluster e segmentou 103 macrorregiões em distintos perfis de cobertura, qualidade e resolubilidade: grupo 1 (alta cobertura/AB e média/AH; baixa qualidade AB-AH com alta resolubilidade); grupo 2 (alta cobertura/AB e baixa/AH; baixa qualidade AB-AH com média resolubilidade); e o grupo 3 (alta cobertura/AB e média/AH; alta qualidade AB-AH com alta resolubilidade). A cobertura na AB foi classificada como alta para 100% da população brasileira, e na AH, baixa para 9,70% e média para 90,29%. Qualidade/AB-AH é baixa para 58,54% e alta para 41,15%. A resolubilidade é alta para 90,29% e média para 9,70%. No Brasil, verifica-se expansão da cobertura com baixa qualidade/AB, insuficiência de leitos hospitalares e baixa qualidade/AH com alta resolubilidade. Todavia, prevalece alta qualidade AB-AH no Sudeste e no Sul. A estruturação das redes de saúde ainda se configura de baixa resolutividade, demandando estímulos à governança de arranjos interfederativos.

Abstract This study seeks to point out the different configurations of Health Care Networks in primary care (AB) and Hospital Care (AH), dimensioned based on coverage, quality, and resolvability characteristics in health macro-regions. Cross-sectional study used the cluster analysis and segmented 103 macro-regions into different profiles of coverage, quality and resolubility: group 1 (high coverage/AB and medium/AH; low quality AB-AH with high resolubility); group 2 (high coverage/AB and low/AH; low quality AB-AH with medium resolubility) and group 3 (high coverage/AB and medium/AH; high quality AB-AH with high resolubility). Coverage in AB was classified as high for 100% of the Brazilian population and in AH low to 9.70% and medium to 90.29%. Quality/AB-AH is low for 58.54% and high for 41.15%. Resolubility is high for 90.29% and medium for 9.70%. In Brazil, there is expansion of coverage with low quality/AB; shortage of hospital beds and low quality/HA with high resolution. However, in the Southeast and South, high AB-AH quality prevails. The structuring of health networks is still characterized by low resolution, demanding incentives for the governance of inter-federal arrangements.

Resumo Este estudo teve como objetivo identificar o perfil de grupos brasileiros de Ginástica para Todos (GPT). Para isto, foi realizada uma pesquisa de caráter quantitativo, na qual foi utilizada um questionário online (Google Forms) respondido por 378 integrantes adultos de 22 grupos. A análise dos dados foi realizada por meio de Estatística Descritiva. Os dados colocam em evidência o protagonismo da região Sudeste, bem como confirmam a forte atuação das universidades públicas no desenvolvimento desta prática gímnica no contexto brasileiro. Ainda que em projetos extensionistas esta diferença seja mais tímida, há um predomínio de integrantes do sexo feminino na composição dos grupos. Quanto a idade dos praticantes, confirmamos a adesão da prática por diferentes faixas etárias, inclusive dentro de um mesmo grupo, porém com uma expressiva dominância de jovens adultos. Por fim, os dados também corroboram a hipótese de que a GPT pode consagrar-se como uma prática de longa permanência, uma vez que mais de um terço dos integrantes relatam fazer parte de seus respectivos grupos a mais de quatro anos.

Abstract This study aimed to identify the profile of Brazilian Gymnastics for All (GfA) groups. Quantitative research was carried out using an online questionnaire (Google Forms) answered by 378 adult members from 22 GfA groups. Data analysis was made using Descriptive Statistics. The data confirm the protagonism of the Southeast region, as well as confirming the strong role of public universities in the GfA development in the Brazilian context. There is a predominance of female participants in the composition of the groups, although in extension projects this difference is lowered. Regarding the age of participants, adherence to the GfA activities by different age groups was confirmed, even within the same group, but with a significant predominance of young adults. Finally, the data also support the hypothesis that GfA can be practiced as a long-term physical activity, as more than a third of the members report being part of their respective groups for over four years.

Abstract The study, focusing on the New Economy, aims to analyze the location of Information Technology (IT) activities in Brazil. Discusses this service sector and its installation in cities and analyzes the presence of companies and employees in Brazil in a comparison on a national scale between the federation units; and between municipalities; while, on a regional scale, it addresses the state of São Paulo. The work uses, above all, the official databases of the Annual List of Social Information (RAIS), linked to the Ministry of Labor and Employment of the federal government, managing to reveal the entire Brazilian territory. The theoretical basis is related to studies of innovation and territory, pointing out that the transformation of the technological base with global contours, from the second half of the 20th century, led to the emergence of a New Economy, which has an emphasis on information, knowledge, learning and innovation. As a result of the study, the presence of IT in Brazilian capitals is presented, especially in the South and Southeast of the country, with the supremacy of São Paulo and its metropolitan region. The study highlights a large concentration of IT activities in large centers, demonstrating the permanence or deepening of territorial inequalities in Brazil.

Resumo O estudo, com foco na Nova Economia, tem por objetivo analisar a localização das atividades de Tecnologias da Informação (TI) no Brasil. Discute este setor de serviços e sua instalação nas cidades, e analisa a presença de empresas e de empregados no Brasil numa comparação em escala nacional entre as unidades da federação; e entre os municípios; enquanto, na escala regional, aborda o estado de São Paulo. O trabalho se vale, sobretudo, dos bancos de dados oficiais da Relação Anual de Informações Sociais (RAIS), vinculada ao Ministério do Trabalho e Emprego do governo federal, conseguindo revelar todo o território brasileiro. A base teórica se relaciona com estudos de inovação e território, apontando que a transformação da base tecnológica com contornos globais, a partir da segunda metade do século XX, propiciou o surgimento de uma Nova Economia, que tem ênfase na informação, no conhecimento, na aprendizagem e na inovação. Como resultado do estudo, é apresentada a presença da TI nas capitais brasileiras, em especial, no Sul e Sudeste do país, com a supremacia de São Paulo e sua região metropolitana. O estudo evidencia uma grande concentração de atividades de TI nos grandes centros, manifestando a permanência ou o aprofundamento das desigualdades territoriais no Brasil.

Resumen El estudio, centrado en la Nueva Economía, tiene como objetivo analizar la localización de las actividades de Tecnologías de la Información (TI) en Brasil. Discute este sector de servicios y su instalación en las ciudades, y analiza la presencia de empresas y empleados en Brasil en una comparación a escala nacional entre las unidades de la federación; y entre municipios; mientras que, a escala regional, aborda el estado de São Paulo. El trabajo utiliza, sobre todo, las bases de datos oficiales de la Lista Anual de Informaciones Sociales (RAIS), vinculada al Ministerio de Trabajo y Empleo del Gobierno Federal, logrando revelar todo el territorio brasileño. La base teórica está relacionada con estudios de innovación y territorio, señalando que la transformación de la base tecnológica con contornos globales, a partir de la segunda mitad del siglo XX, propició el surgimiento de una Nueva Economía, que tiene énfasis en la información, conocimiento, aprendizaje e innovación. Como resultado del estudio, se presenta la presencia de TI en las capitales brasileñas, especialmente en el Sur y Sudeste del país, con supremacía de São Paulo y su región metropolitana. El estudio destaca una gran concentración de actividades de TI en grandes centros, lo que demuestra la permanencia o profundización de las desigualdades territoriales en Brasil.

RESUMO Na pandemia da COVID-19, os povos indígenas do sudeste do Pará enfrentaram, dentre tantas emergências, o agravamento das violações territoriais e as precarizações de atenção à saúde e à educação, sem privá-los da resiliência ao capitalismo da fronteira na região. As informações obtidas por entrevistas junto a lideranças indígenas, consulta de dados oficiais e aqueles publicizados pela Articulação dos Povos Indígenas do Brasil (APIB), além de anotações de campo sobre a atuação da Rede de Apoio Mútuo aos Povos Indígenas do Sudeste do Pará, evidenciam o uso estratégico do território para isolamento e recrudescimento de práticas culturais, e a formulação de políticas de resistência às crises sistêmicas agravadas pelo governo nacional fascistóide do período.

ABSTRACT In the COVID-19 pandemic, indigenous peoples in the southeast of Pará faced, among many emergencies, the worsening of territorial violations and precarious health care and education, without depriving them of resilience to frontier capitalism in the region. The information obtained through interviews with indigenous leaders, consultation of official data and those published by the Articulation of Indigenous Peoples of Brazil (APIB), as well as field notes on the performance of the Mutual Support Network to Indigenous Peoples of Southeastern Brazil Pará, highlights the strategic use of the territory for isolation and resurgence of cultural practices, and the formulation of policies to resist the systemic crises aggravated by the fascist national government of the period.

RESUMEN En la pandemia de COVID-19, los pueblos indígenas del sureste de Pará enfrentaron, entre muchas emergencias, el agravamiento de las violaciones territoriales y la precariedad en la atención de salud y educación, sin privarlos de resiliencia al capitalismo de frontera en la región. Mediante la información obtenida a través de entrevistas con líderes indígenas, consulta de datos oficiales y publicados por la Articulación de los Pueblos Indígenas de Brasil (APIB), así como de notas de campo sobre el desempeño de la Red de Apoyo Mutuo a los Pueblos Indígenas del Sudeste de Pará en Brasil, se resalta el uso estratégico del territorio para el aislamiento y el resurgimiento de prácticas culturales, y la formulación de políticas para resistir las crisis sistémicas agravadas por el gobierno nacional fascista del período.

Abstract This study describes and illustrates the biodiversity of macroinvertebrates associated to Sargassum and Dictyota seaweed habitats in the Alcatrazes archipelago, the largest Marine Protected Area (MPA) in the state of São Paulo, southeast Brazil. Assemblages were sampled during the summers of 2018, 2019 and 2020 and winter of 2018 at two sites on the main island. Macroalgae containing the associated fauna were collected at approximately 10 meters deep, with six samples at each site and in each sampling campaign. Sargassum fronds prevailed during summer collections, whilst were absent in the winter campaigns, when Dictyota was the most frequent seaweed. Among invertebrates, 32 species were exclusively found on summer months, associated to Sargassum beds, while 12 species were only registered on winter collection, in association with Dictyota. In total, 91 species were identified, belonging to 60 families, 19 orders, 7 classes and 3 phyla, including Arthropoda (Malacostraca and Pycnogonida), Mollusca (Gastropoda, Bivalvia and Polyplacophora), and Echinodermata (Ophiuroidea and Echinoidea). Among the 91 species found, 73 species are new records for the Alcatrazes archipelago marine area, thus revealing the expressive invertebrate biodiversity living in association with macroalgae beds in that area, which has still been little explored. No significant difference in species diversity was found between the two sites of Alcatrazes. In addition, few specimens of two invasive species were found: Perna perna (Mollusca: Bivalvia) and Ophiothela mirabilis (Echinodermata: Ophiuroidea), which underscores the importance of monitoring different habitats within MPAs to check for possible changes in the fauna over the years. As far as our knowledge, this is the first illustrated inventory of the seaweed-associated macroinvertebrate fauna within the Alcatrazes Archipelago, one of the largest MPAs in the Brazilian coast; besides unravelling its notorious biodiversity, this can act as a reference for future monitoring of local coastal diversity. MPA (MPA Paulo Brazil 201 202 island 1 deep campaign collections campaigns invertebrates months collection total 9 identified 6 families orders phyla Malacostraca Pycnogonida, Pycnogonida , Pycnogonida) Gastropoda, Gastropoda (Gastropoda Polyplacophora, Polyplacophora Polyplacophora) Ophiuroidea Echinoidea. Echinoidea . Echinoidea) area explored addition (Mollusca (Echinodermata Ophiuroidea, Ophiuroidea) years knowledge seaweedassociated Archipelago coast 20 2

Resumo Este estudo descreve e ilustra a biodiversidade de macroinvertebrados associados a habitats de macroalgas pardas marinhas dos gêneros Sargassum e Dictyota no Arquipélago de Alcatrazes, a maior Área Marinha Protegida (AMP) do estado de São Paulo, sudeste do Brasil. As assembleias foram amostradas durante os verões de 2018, 2019 e 2020 e no inverno de 2018 em dois locais na ilha principal. As macroalgas contendo a fauna associada foram coletadas a aproximadamente 10 metros de profundidade, com seis amostras em cada local e em cada campanha amostral. Frondes de Sargassum predominaram nas coletas de verão, enquanto estiveram ausentes nas campanhas de inverno, quando Dictyota foram predominantes. Entre os invertebrados, 32 espécies foram encontradas exclusivamente nos meses de verão, associadas aos bancos de Sargassum, enquanto 12 espécies foram registradas apenas na coleta de inverno, em associação com Dictyota. No total, foram identificadas 91 espécies, pertencentes a 60 famílias, 19 ordens, 7 classes e 3 filos, incluindo Arthropoda (Malacostraca e Pycnogonida), Mollusca (Gastropoda, Bivalvia e Polyplacophora) e Echinodermata (Ophiuroidea e Echinoidea). Das 91 espécies encontradas, 73 espécies são novos registos para a área marinha do arquipélago de Alcatrazes, revelando assim a expressiva biodiversidade de invertebrados que vivem em associação com bancos de macroalgas naquela área ainda pouco explorada. Nenhuma diferença significativa de diversidade de espécies foi encontrada entre os dois locais de Alcatrazes. Além disso, foram encontrados poucos exemplares de duas espécies invasoras: Perna perna (Mollusca: Bivalvia) e Ophiothela mirabilis (Echinodermata: Ophiuroidea), o que ressalta a importância do monitoramento de diferentes habitats dentro das AMPs para verificar possíveis alterações na fauna ao longo dos anos. Até onde sabemos, este é o primeiro inventário ilustrado da fauna de macroinvertebrados associados a algas marinhas no Arquipélago de Alcatrazes, uma das maiores AMPs da costa brasileira; além de desvendar a sua notória biodiversidade, pode servir de referência para futuro monitoramento da diversidade costeira local. Alcatrazes AMP (AMP Paulo Brasil 201 202 principal 1 profundidade amostral verão predominantes total 9 6 famílias ordens filos Malacostraca Pycnogonida, Pycnogonida , Pycnogonida) Gastropoda, Gastropoda (Gastropoda Polyplacophora Ophiuroidea Echinoidea. Echinoidea . Echinoidea) explorada disso invasoras (Mollusca (Echinodermata Ophiuroidea, Ophiuroidea) anos sabemos brasileira 20 2

Resumo Dentre as espécies de Bemisia tabaci, as espécies invasoras MEAM1 e MED se destacam como pragas de grande importância para várias culturas. No Brasil, a maior parte dos surtos populacionais de mosca-branca são associados a presença da espécie MEAM1, que a partir 1990 se espalhou por todo o país. Por outro lado, em 2014 a espécie MED foi identificada no Brasil, inicialmente restrita a casas de vegetação, mas rapidamente se difundindo em novas áreas nas regiões Sul e Sudeste do Brasil. Assim, nosso objetivo foi investigar a distribuição geográfica das espécies MEAM1 e MED em grandes culturas no Brasil. A espécie MEAM1 continua sendo predominante nas monoculturas como algodão, soja e tomate. O sequenciamento de um fragmento do gene citocromo c oxidase subunidade I (COI) revelou a presença de um haplótipo para MEAM1, sugerindo o estabelecimento de apenas uma linhagem no país. Os haplótipos encontrados para MEAM1 e MED são geneticamente relacionados as linhagens globalmente dispersas Jap1 e Mch1, respectivamente. O monitoramento contínuo das espécies de B. tabaci é crucial pois as mudanças na paisagem, mudanças climáticas e métodos de manejo das pragas podem alterar a dominância e a distribuição dessas espécies nas áreas agrícolas do Brasil.

Abstract Among Bemisia tabaci species, the invasive MEAM1 and MED species are key agricultural pests for many crops. In Brazil, most part of B. tabaci population outbreaks were associated with MEAM1, which, since 1990s quickly spread across the entire country. Later in 2014, the MED was identified in Brazil, initially more restricted to greenhouses, but suddenly reaching new areas in the South and Southeast open regions. Thus, our objective was to investigate the geographical distribution of MEAM1 and MED on open field crops in Brazil. MEAM1 is still the predominant species on open field crops such as soybean, cotton, and tomato. The sequencing of a cytochrome c oxidase subunit I (COI) gene fragment revealed a single haplotype of MEAM1, suggesting the establishment of a single MEAM1 strain in the country. The haplotypes found for MEAM1 and MED are genetically related to the globally dispersed strains, Jap1 and Mch1, respectively. Continuous monitoring of B. tabaci species is crucial because landscape alterations, climatic changes, and pest management methods may shift the B. tabaci species distribution and dominance in Brazilian crop areas.

RÉSUMÉ L’article présente et analyse l’histoire et les liens de différentes expériences de commerce du livre à São Paulo, Minas Gerais et Rio de Janeiro, entre 1972 et 2018, à savoir : Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra , Iná Livros et Livraria Africanidades. Des librairies spécifiquement noires, avec des propriétaires noirs, dédiées à la littérature en circulation produite et éditée par des auteurs noirs et/ou africains. Parfois, avec des liens avec des associations et des mouvements noirs contemporains. Compte tenu de la rareté des recherches sur cet objet spécifique, la principale méthode utilisée a été l’entretien structuré avec les sujets impliqués dans l’activité, l’analyse des sources secondaires, ainsi que l’utilisation de la recherche dans les journaux, qui s’est avérée très importante pour comprendre certaines des les significations sociales attribuées par les commerçants noirs à leur activité, leur portée, leurs liens de sens et limites. Larticle L article lhistoire l histoire Paulo Janeiro 197 2018 Contexto Eboh Griot Café Africanidades noires etou ou africains Parfois contemporains spécifique lentretien entretien lactivité, lactivité activité l’activité lanalyse secondaires lutilisation utilisation journaux sest s est portée limites 19 201 1 20 2

RESUMEN El artículo presenta y analiza la historia y las conexiones de diferentes experiencias de comercio de libros en São Paulo, Minas Gerais y Rio de Janeiro, entre 1972 y 2018, a saber: Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra, Iná Livros, Livraria Africanidades . Estas son, específicamente, librerías negras, de propietarias negras y dueños negros, que se dedicaron a hacer circular la literatura producida y editada por autoría negra y/o africana. En ocasiones, estas librerías han tenido conexiones con asociaciones y movimientos negros coetáneos. Considerando la escasez de investigaciones sobre este objeto de estudio en específico, fue utilizado como método principal la entrevista estructurada con los sujetos involucrados en esta actividad, el análisis de fuentes secundarias, así como la investigación en periódicos, que se reveló bastante importante para comprender algunos de los sentidos sociales atribuidos por los comerciantes negros a su actividad, sus alcances, conexiones de sentidos y límites. Paulo Janeiro 197 2018 saber Contexto Eboh Griot Café Negra Livros son específicamente yo o africana ocasiones coetáneos específico actividad secundarias periódicos alcances límites 19 201 1 20 2

ABSTRACT This article presents and analyzes the history and connections among various black bookstore experiences in Southeast Brazil between 1972 and 2018. Given the lack of research on the topic in Brazil, this study relies heavily on structured interviews with some of the individuals in the sector, as well as on the analysis of secondary data and news. The stores studied are Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra, Iná Livros and Livraria Africanidades, located in the states of São Paulo, Minas Gerais and Rio de Janeiro. They are owned by black women and men devoted to selling black and African literature, some of whom have been activists in different segments of Brazil’s black movements. Our findings have advanced a deeper understanding of the social meanings black traders assign to their activity, their reach, the connections among their purposes, and their limitations. 197 2018 sector news Contexto Eboh Griot Café Negra Africanidades Paulo Janeiro literature Brazils s movements activity reach purposes limitations 19 201 1 20 2

RESUMO O artigo apresenta e analisa a história e as conexões de diferentes experiências de comércio livreiro em São Paulo, Minas Gerais e Rio de Janeiro, entre 1972 e 2018, a saber: Livraria Contexto, Livraria Eboh, Livraria Griot, Sobá Livraria e Café, Kitabu Livraria Negra, Iná Livros, Livraria Africanidades. Especificamente livrarias negras, de proprietárias negras e donos negros, que se dedicaram a fazer circular a literatura produzida e editada pela autoria negra e/ou africana. Por vezes, com conexões com associações e movimentos negros coetâneos. Considerando a escassez de pesquisas sobre este objeto específico, foi utilizado como método principal a entrevista estruturada com os sujeitos envolvidos na atividade, análise de fontes secundárias bem como o recurso a pesquisa em jornais, que se revelou bastante importante para compreender alguns dos sentidos sociais atribuídos pelos comerciantes negros em sua atividade, seus alcances, conexões de sentidos e limites. Paulo Janeiro 197 2018 saber Contexto Eboh Griot Café Negra Livros Africanidades eou ou africana vezes coetâneos específico atividade jornais alcances limites 19 201 1 20 2

ABSTRACT Objective: To describe the epidemiological profile and prevalence of live births with orofacial clefts in Brazil between 1999 and 2020. Methods: Descriptive study. The population corresponded to live births with isolated orofacial clefts in Brazil registered in the Live Birth Information System between 1999 and 2020. Descriptive variables were selected according to their availability and grouped into socioeconomic and demographic, maternal and child health care, and biological variables. Data were submitted to a descriptive analysis using the Software for Statistics and Data Science (STATA). Results: During the period, 33,699 children were born with orofacial clefts, and 82.1% (27,677) of them were isolated clefts. Regarding these cases, the majority were cleft lip and palate (9,619 or 34.7%), followed by cleft palate (9,442 or 34.1%), and by cleft lip (8,616 or 31.3%). Conclusions: Live births with orofacial clefts in Brazil were male, white, with birthweight ≥2,500 g and gestational age ≥37 weeks, born by cesarean section, and with Apgar scores ≥7. The cases were more frequent among mothers who were in their first and single pregnancy and had seven or more prenatal appointments. The mothers were 20 and 29 years old, had eight to ten years of study, and were single. The national prevalence of clefts was 4.24/10,000. The South and Southeast regions of Brazil had the highest prevalence, while the lowest prevalence was recorded in the Northeast and North regions. For the Federative Units, the highest and lowest prevalences were found, respectively, in Paraná and Acre. Objective 199 2020 Methods study demographic care STATA. STATA . (STATA) Results period 33699 33 699 33,69 821 82 1 82.1 27,677 27677 27 677 (27,677 9,619 9619 9 619 (9,61 34.7%, 347 34.7% , 34 7 34.7%) 9,442 9442 442 (9,44 34.1%, 341 34.1% 34.1%) 8,616 8616 8 616 (8,61 31.3%. 313 31.3% 31 3 31.3%) Conclusions male white 2500 2 500 ≥2,50 37 ≥3 weeks section ≥7 appointments old 42410000 4 24 10 000 4.24/10,000 Units found respectively Acre 19 202 (STATA 3369 69 33,6 82. 27,67 2767 67 (27,67 9,61 961 61 (9,6 34.7 9,44 944 44 (9,4 34.1 8,61 861 (8,6 31.3 250 50 ≥2,5 ≥ 4241000 00 4.24/10,00 336 6 33, 27,6 276 (27,6 9,6 96 (9, 34. 9,4 94 8,6 86 (8, 31. 25 5 ≥2, 424100 0 4.24/10,0 27, (27, 9, (9 8, (8 ≥2 42410 4.24/10, (27 ( 4241 4.24/10 (2 424 4.24/1 42 4.24/ 4.24 4.2 4.

RESUMO Objetivo: Descrever o perfil epidemiológico e a prevalência dos nascidos vivos com fissuras orofaciais no Brasil entre 1999 e 2020. Métodos: Estudo descritivo. A população correspondeu aos nascidos vivos com fissuras orofaciais isoladas no Brasil registrados no Sistema de Informação de Nascidos Vivos entre 1999 e 2020. As variáveis descritivas foram selecionadas de acordo com a sua disponibilidade e agrupadas em variáveis socioeconômicas e demográficas, de atenção à saúde materno-infantil e biológicas. Os dados foram submetidos a análise descritiva utilizando o Software for Statistics and Data Science (STATA). Resultados: No período, 33.699 indivíduos nasceram com fissura orofacial no Brasil, e 82,1% (27.677) deles foram fissuras isoladas. Com relação a esses casos, a maioria foi de fissuras de lábio e palato (9.619 ou 34,7%), seguidas por fissura de palato (9.442 ou 34,1%) e por fissura de lábio (8.616 ou 31,1%). Conclusões: O perfil epidemiológico dos nascidos vivos com fissuras orofaciais no Brasil foi de nascidos do sexo masculino, da raça/cor branca, por parto cesáreo, com peso ao nascer ≥2,500 g, idade gestacional ≥37 semanas e com índices de Apgar ≥7. Os casos foram mais frequentes entre mães que estavam na primeira gestação, única e que haviam realizado sete ou mais consultas de pré-natal. As mães, com maior frequência, tinham entre 20 e 29 anos, apresentavam oito ou mais anos de estudo, eram solteiras e residiam em cidades do interior. A prevalência nacional de fissuras foi de 4,24/10.000. As Regiões Sul e Sudeste apresentaram as maiores prevalências, enquanto as menores foram registradas nas Regiões Nordeste e Norte. Para as Unidades Federativas, as maiores e menores prevalências foram encontradas, respectivamente, no Paraná e no Acre. Objetivo 199 2020 Métodos descritivo demográficas maternoinfantil materno infantil biológicas STATA. STATA . (STATA) Resultados período 33699 33 699 33.69 821 82 1 82,1 27.677 27677 27 677 (27.677 9.619 9619 9 619 (9.61 34,7%, 347 34,7% , 34 7 34,7%) 9.442 9442 442 (9.44 34,1% 341 8.616 8616 8 616 (8.61 31,1%. 311 31,1% 31 31,1%) Conclusões masculino raçacor raça cor branca cesáreo 2500 2 500 ≥2,50 g 37 ≥3 ≥7 gestação prénatal. prénatal pré natal. natal pré-natal frequência estudo interior 42410000 4 24 10 000 4,24/10.000 Norte Federativas encontradas respectivamente Acre 19 202 (STATA 3369 3 69 33.6 82, 27.67 2767 67 (27.67 9.61 961 61 (9.6 34,7 9.44 944 44 (9.4 34,1 8.61 861 (8.6 31,1 250 50 ≥2,5 ≥ 4241000 00 4,24/10.00 336 6 33. 27.6 276 (27.6 9.6 96 (9. 34, 9.4 94 8.6 86 (8. 31, 25 5 ≥2, 424100 0 4,24/10.0 27. (27. 9. (9 8. (8 ≥2 42410 4,24/10. (27 ( 4241 4,24/10 (2 424 4,24/1 42 4,24/ 4,24 4,2 4,