The inhibition of the fatty acid amide hydrolase (FAAH), an endocannabinoid system component, emerged as a potentially new therapeutic target for a range of clinical disorders such as acute and chronic pain. Some α-ketoheterocycle derivatives demonstrated interesting analgesic and anti-inflammatory activities in vitro. Ligand-Based Drug Design techniques such as knowledge graph convolutional networks (kGCN) and hologram quantitative structure-activity relationship (HQSAR) using α-ketoheterocycle derivatives from five different datasets were generated to discover the relation between the chemical structures and the inhibition activity. Meanwhile, structure-based drug design simulations as interaction fields (MIF), molecular docking, and ligand sites studies (LSI) from FAAH were performed using Autogrid software and FTmap/FTsite servers. The results of both studies were merged to propose predictive models. The resulting kGCN model demonstrated adequate accuracy area under the curve by receiver operating characteristic (AUC-ROC 0.7922). From contribution maps of the Ligand-Based Drug Design (LBDD) models and the generated probes using MIF and LSI, it was observed that the oxazole ring, the ketone group, and the apolar chain present in the structures of the inhibitors are important, besides the evidence of the Cys269 and Val270 residues importance for the potential interaction, confirmed by carried docking studies. These fragments and structural information can be used to carry out new FAAH potential inhibitors studies and report kGCN as an accurate classification technique. FAAH, , (FAAH) component pain αketoheterocycle α ketoheterocycle antiinflammatory anti inflammatory vitro LigandBased Ligand Based (kGCN structureactivity structure activity HQSAR (HQSAR Meanwhile structurebased based MIF, (MIF) LSI (LSI FTmapFTsite FTmap FTsite servers AUCROC AUC ROC 0.7922. 07922 0.7922 . 0 7922 0.7922) LBDD (LBDD ring group important Cys Cys26 Val Val27 technique (FAAH (MIF 0792 0.792 792 Cys2 Val2 079 0.79 79 07 0.7 7 0.

Resumen La agricultura es una actividad humana vital que contribuye al desarrollo sostenible. Hace unas décadas, el sector agrícola introdujo el Internet de las Cosas (IoT), desempeñando un papel relevante en la agricultura de precisión e inteligente. Los desarrollos IoT en agricultura requieren colaboración entre múltiples dispositivos, lo que incrementa su vulnerabilidad, debido principalmente a la falta de seguridad integrada por restricciones del contexto. Otras amenazas a estos dispositivos conciernen el almacenamiento y procesamiento de datos conectados a servidores periféricos o en nube. Para garantizar que las soluciones IoT cumplen los requisitos funcionales y no funcionales, especialmente los de seguridad, las empresas de software deberían adoptar un enfoque centrado en la seguridad para su especificación de requerimientos de software. El objetivo del artículo consistió en proponer un método ligero para especificar escenarios de seguridad integrando los puntos de vista de requisitos y arquitectura en el contexto del IoT en soluciones agrícolas. El método comprende cuatro actividades: (i) crear escenarios de buen uso, (ii) crear escenarios de uso incorrecto, (iii) traducir el escenario anterior en escenario de seguridad aplicando reglas y (iv) refinar el escenario de seguridad resultante. También se describe un prototipo de herramienta que utiliza el algoritmo propuesto para ayudar a reforzar el escenario de uso incorrecto basado en el escenario de uso correcto, dando al experto la posibilidad de completar la información para el análisis y posterior derivación del escenario de seguridad. Por último, se proporciona una evaluación preliminar del método propuesto. Los resultados de mostraron que el enfoque propuesto permite a los ingenieros de software definir y analizar escenarios de seguridad en los contextos de IoT y agricultura con buenos resultados. La encuesta, aplicada a cinco expertos en seguridad, encontró que el método de escenario de seguridad propuesto es generalmente útil, pero necesita mejoras en diferentes áreas.

Abstract Agriculture is a vital human activity that contributes to sustainable development. A few decades ago, the agricultural sector adopted the Internet of Things (IoT), which has played a relevant role in precision and smart farming. The IoT developments in agriculture require that numerous connected devices work cooperatively. This increases the vulnerability of IoT devices, mainly because they lack the necessary built-in security because of their context and computational capacity. Other security threats to these devices are related to data storage and processing connected to edge or cloud servers. To ensure that IoT-based solutions meet functional and non-functional requirements, particularly those concerning security, software companies should adopt a security-focused approach to their software requirements specification. This paper proposes a method for specifying security scenarios, integrating requirements and architecture viewpoints into the context of IoT for agricultural solutions. The method comprises four steps: (i) describe scenarios for the intended software, (ii) describe scenarios with incorrect uses of the system, (iii) translate these scenarios into security scenarios using a set of rules, and (iv) improve the security scenarios. This paper also describes a prototype application that employs the proposed algorithm to strengthen the incorrect use scenario based on the correct use scenario. Then, the expert can complete the information for the analysis and subsequent derivation of the security scenario. In addition, this paper describes a preliminary validation of our approach. The results show that the proposed approach enables software engineers to define and analyze security scenarios in the IoT and agricultural contexts with good results. A survey administered to five security experts found that the proposed security scenario method is generally useful for specifying agricultural IoT solutions but needs improvement in different areas.

In this research, a meticulous screening process was conducted using four servers: Drug Target Explorer, Swiss Target Predictor, SEA Predictor, and Target Hunter. The primary objective was to identify a series of potential biological targets related to the regulation of cell growth and apoptosis in cancer cells using cinnamic acid derivatives. This study focused on five specific targets, matrix metallopeptidase 9 (MMP9), apoptosis inducing factor (AIF), aldo-keto reductase family 1 member C3 (AKR1C3), aldo-keto reductase family 1 member B10 (AKR1B10), mitogen-activated protein kinase 14 (MAPK14), all of which are well known to play a significant role in cancer cell dynamics. To explore both molecular recognition and molecular dynamics, a series of in silico investigations (docking and molecular dynamics) were carried out using a collection of 14 cinnamic acid derivatives, including cinnamic acid phenethyl ester (CAPE) as a notable reference molecule due to its widely recognized anticancer effects. Furthermore, preliminary in vitro data revealed a potentially promising cytotoxic effect of (E)-N-[(3,4-dichlorophenyl)methyl]-3-(4-phenoxyphenyl)-2-propenamide (LQM755) on a human gastric adenocarcinoma cell-line (AGS cells), which are characterized by the overexpression of the MMP9 protein. Therefore, the chemical compound LQM755 provides an initial perspective in the field of cancer therapy. research servers Explorer Predictor Hunter derivatives MMP9, MMP , (MMP9) AIF, AIF (AIF) aldoketo aldo keto C AKR1C3, AKR1C3 AKRC AKR (AKR1C3) B B1 AKR1B10, AKR1B10 AKRB (AKR1B10) mitogenactivated mitogen activated MAPK14, MAPK14 MAPK (MAPK14) dynamics docking CAPE (CAPE effects Furthermore EN3,4dichlorophenylmethyl34phenoxyphenyl2propenamide EN34dichlorophenylmethyl34phenoxyphenyl2propenamide ENdichlorophenylmethylphenoxyphenylpropenamide E N 3,4 dichlorophenyl methyl 3 4 phenoxyphenyl 2 propenamide LQM (LQM755 cellline line AGS cells, cells) Therefore LQM75 therapy (MMP9 (AIF AKR1C (AKR1C3 AKR1B1 (AKR1B10 MAPK1 (MAPK14 EN3 4dichlorophenylmethyl34phenoxyphenyl2propenamide EN dichlorophenylmethyl 34 3, (LQM75 LQM7 (MMP (AKR1C AKR1B (AKR1B1 (MAPK1 dichlorophenylmethylphenoxyphenylpropenamide (LQM7 (AKR1B (MAPK (LQM

Abstract The Internet of Things (IoT) security is a highly challenging research domain. The IoT user devices frequently function in vulnerable platforms that cause many security problems that can be considered. The model lightweight cryptographic (LWC) method stake place to reflect the importance of cryptographic systems which offer safety with the employ of an effectual count of resources. The purpose of the lightweight system's design is to strike a balance in many features like low resource demand, performance, and cryptographic algorithm stability and strength. Therefore, this study develops a new Improved Lightning Search Algorithm based End-to-End Lightweight Partially Homomorphic Encryption Approach (ILSA-LPHEA) for Securing the IoT Environment. For securing the data in the IoT environment, a lightweight partially homomorphic encryption (PHE) approach is used. Since key generation remains an important process to establish secure data transmission among IoT devices and servers, the ILSA is used. The hybridization of lightweight encryption with PHE strategy provides better security by enhancing privacy, confidentiality, and authentication, enabling end-to-end encryption. A detailed experimental result analysis highlighted the better solution of the ILSA-LPHEA algorithm with recent models. (IoT domain considered LWC (LWC resources system s demand performance strength Therefore EndtoEnd End ILSALPHEA LPHEA (ILSA-LPHEA Environment environment (PHE used servers privacy confidentiality authentication endtoend end models

Abstract In conjunction with emergency public health actions to control the new coronavirus pandemic, there are several efforts to reduce the negative impact on workers’ mental health. The objective of the research is to understand if there is an impact relationship between the Covid-19 pandemic and the mental health of the servers of the Federal University of Goiás. Through the case study, a descriptive analysis, frequency distribution and correspondence analysis were performed using the Sphinx® system, for variables with the same categories of secondary data responses, from an institutional survey carried out by UFG. The study shows that there is an impact relationship between the Covid-19 pandemic and the mental health of servers, in addition, the work regime, which placed most servers in remote work, was a catalyst for mental disorders such as anxiety, depression and others. Communication presents itself as a problem and some groups of servers felt the impact at a higher level such as the elderly, professionals who have children, especially female individuals, and outsourced workers. Finally, an internal communication program for the health care of the UFG server is presented. workers Covid19 Covid 19 Covid-1 Goiás Sphinx system responses addition regime anxiety others elderly children individuals Finally presented Covid1 1 Covid-

Resumo Em conjunto com as ações emergenciais de saúde pública para controlar a pandemia do novo coronavírus, há vários esforços para reduzir o impacto negativo na saúde mental dos trabalhadores. O objetivo da pesquisa é compreender se existe uma relação de impacto entre a pandemia de Covid-19 e a saúde mental dos servidores da Universidade Federal de Goiás. Por meio do estudo de caso, foi realizada uma análise descritiva, distribuição de frequência e análise de correspondência a partir do sistema Sphinx®, para as variáveis com as mesmas categorias de respostas de dados secundários, oriundos de uma pesquisa institucional realizada pela UFG. O estudo mostra que há uma relação de impacto entre a pandemia de Covid-19 e a saúde mental dos servidores, além disso, o regime de trabalho, que inseriu a maior parte dos servidores em trabalho remoto, foi um catalisador de transtornos mentais como ansiedade, depressão e outros. A comunicação se apresenta como uma problemática e alguns grupos de servidores sentiram o impacto em maior nível como os idosos, os profissionais que possuem filhos, em especial, os indivíduos do gênero feminino, e os terceirizados. Por fim, apresenta-se um programa de comunicação interna de atenção à saúde do servidor da UFG. coronavírus trabalhadores Covid19 Covid 19 Covid-1 Goiás caso descritiva Sphinx Sphinx® secundários UFG disso remoto ansiedade outros idosos filhos especial feminino terceirizados fim apresentase Covid1 1 Covid-

Resumen Junto con las acciones de salud pública de emergencia para controlar la pandemia del nuevo coronavirus, existen varios esfuerzos para reducir el impacto negativo en la salud mental de los trabajadores. El objetivo de la investigación es comprender si existe una relación de impacto entre la pandemia de Covid-19 y la salud mental de los servidores de la Universidad Federal de Goiás. A través del estudio de caso, se realizó un análisis descriptivo, distribución de frecuencias y análisis de correspondencias utilizando el sistema Sphinx®, para variables con las mismas categorías de respuestas de datos secundarios, de una encuesta institucional realizada por la UFG. El estudio muestra que existe una relación de impacto entre la pandemia del Covid-19 y la salud mental de los servidores, además, el régimen de trabajo, que colocó a la mayoría de los servidores en trabajo remoto, fue un catalizador de trastornos mentales como ansiedad, depresión y otros. La comunicación se presenta como un problema y algunos grupos de servidores sintieron el impacto en un nivel superior como los ancianos, profesionales que tienen hijos, especialmente mujeres, y trabajadores subcontratados. Finalmente, se presenta un programa de comunicación interna para el cuidado de la salud del servidor de la UFG. coronavirus Covid19 Covid 19 Covid-1 Goiás caso descriptivo Sphinx Sphinx® secundarios UFG además remoto ansiedad otros ancianos hijos mujeres subcontratados Finalmente Covid1 1 Covid-

Abstract The aim of this article is to outline the organizational commitment and entrenchment profiles of civil servants from the Brazilian Federal Revenue Office, comparing sociodemographic and occupational variables in the identified profiles. A quantitative, descriptive, cross-sectional study was carried out, collecting data via an online survey responded by 1,126 civil servants. Latent profile analysis was used to study the data, revealing four distinct organizational attachment profiles: i) moderately attached; ii) low attachment (predominantly uncommitted); iii) low attachment; iv) attached (predominantly committed). Most of the participants belonged to profiles with moderate and high levels of affective commitment. A shorter length of service and younger age predicted low attachment profiles, while senior positions were associated with profiles with higher levels of commitment and adjustment to social position (a dimension of entrenchment). Identifying these differences in profiles is a relevant contribution to more personalized and focused management of people and relationships. Office quantitative descriptive crosssectional cross sectional out 1126 1 126 1,12 i ii predominantly uncommitted uncommitted) iii iv committed. committed . committed) entrenchment. entrenchment) relationships 112 12 1,1 11 1,

Resumo Este artigo tem como objetivo delinear os perfis de comprometimento e entrincheiramento organizacional de servidores públicos da Receita Federal do Brasil, comparando as variáveis sociodemográficas e ocupacionais nos perfis identificados. Para tanto, foi realizada uma pesquisa quantitativa, descritiva e com corte transversal. Os dados foram coletados via survey online, e participaram 1.126 servidores. Para o estudo dos dados, utilizou-se a técnica de análise de perfis latentes. Como resultado, foram identificados quatro perfis de vínculos organizacionais: i) moderadamente vinculado; ii) baixo vínculo, predominantemente descomprometido; iii) baixo vínculo; iv) vinculado, predominantemente comprometido. A maior parte dos participantes pertence aos perfis com níveis moderados e altos de comprometimento afetivo. Menor tempo de serviço e menos idade predisseram perfis de baixo vínculo, enquanto ocupantes de cargo de chefia estiveram associados aos perfis com maiores níveis de comprometimento e de ajustamento à posição social (dimensão do entrincheiramento). A identificação dessas diferenças nos perfis é uma contribuição relevante para uma gestão de pessoas e de vínculos mais personalizada e focada. Brasil tanto quantitativa transversal online 1126 1 126 1.12 utilizouse utilizou se latentes resultado organizacionais i vinculado ii vínculo descomprometido iii iv comprometido afetivo dimensão entrincheiramento. . entrincheiramento) focada 112 12 1.1 11 1.

Resumen El objetivo de este artículo es delinear los perfiles de compromiso y arraigo organizacional de funcionarios de la Hacienda Nacional de Brasil, comparando variables sociodemográficas y ocupacionales en los perfiles identificados. Para ello, se realizó un estudio cuantitativo, descriptivo y transversal. Los datos se recogieron por medio de una encuesta en línea y participaron 1.126 funcionarios. Se utilizó la técnica de análisis de perfiles latentes para estudiar los datos. Como resultado, se identificaron cuatro perfiles de apego organizativo: i) moderadamente apegado; ii) poco apegado, predominantemente no comprometido; iii) poco apegado; iv) apegado, predominantemente comprometido. La mayoría de los participantes pertenece a los perfiles con niveles moderados y altos de compromiso afectivo. La menor antigüedad en el servicio y la menor edad predijeron perfiles de bajo apego, mientras que los cargos superiores se asociaron a perfiles con mayores niveles de compromiso y ajuste a la posición social (dimensión de arraigo). La identificación de estas diferencias en los perfiles es una contribución relevante para una gestión más personalizada y centrada en las personas y las relaciones. Brasil identificados ello cuantitativo transversal 1126 1 126 1.12 resultado organizativo i apegado ii comprometido iii iv afectivo dimensión arraigo. . arraigo) relaciones 112 12 1.1 11 1.

ABSTRACT The temporal bin packing problem with fire-ups (TBPP-FU) is a two-dimensional packing problem where one geometric dimension is replaced by a time horizon. The given items (jobs) are characterized by a resource consumption, that occurs exclusively during an activity interval, and they have to be placed on servers so that the capacity constraint is respected at any time. For energy efficiency reasons, an optimal assignment shall minimize a weighted sum of the number of servers in use and the number of switch-on processes (so-called fire-ups) resulting from the selected configuration. The associated ILP formulations are typically large in size, so that, in the recent past, several model improvements have already been proposed in the literature. However, with only one exception, all these techniques do not address the quality of the LP bound which is another crucial factor for the size of the branch-and-bound trees generated during the solution process. To this end, we present a new class of valid inequalities, contributing to a stronger LP relaxation, and discuss their numerical benefits by computational experiments based on benchmark instances and new test sets. Remarkably, the new cuts also lead to theoretical results about the optimal value of the LP relaxation. fireups fire ups TBPPFU TBPP FU (TBPP-FU twodimensional two dimensional horizon jobs (jobs consumption interval reasons switchon switch socalled called configuration past literature However exception branchandbound branch process end inequalities relaxation sets Remarkably

ABSTRACT The general objective of the research was to describe the practice of ethics and labor law of workers. It was developed from a quantitative approach. In addition, it was supported by documentary-bibliographic analysis, consisting of refereed articles, theses and standards, for their respective analysis and interpretation. The survey technique was used, which was applied to a sample of 164 servers and officials of the Local Educational Management Unit, Chepén, 2023. It is concluded that the practice of ethics in the labor law of the workers of the Chepén Local Educational Management Unit is directly related as evidenced in the results obtained. This leads to an efficient labor activity, related to the respect for individual and collective rights and values, which allows facing difficulties in the exercise of the public function.

RESUMEN El objetivo general de la investigación fue describir la práctica de la ética y el derecho laboral de los trabajadores. Se desarrolló desde el enfoque cuantitativo. Además, se apoyó en el análisis documental-bibliográfico, conformados por artículos arbitrados, tesis y normas, para su respectivo análisis e interpretación. Se utilizó la técnica de la encuesta, la cual fue aplicada a una muestra de 164 servidores y funcionarios de la Unidad de Gestión Educativa Local, Chepén, 2023. Se concluye que, la práctica de la ética en el derecho laboral de los trabajadores de la Unidad de gestión Educativa Local Chepén, guarda relación directa como se evidencia en los resultados obtenidos. Lo que conduce a una eficiente actividad laboral, guardando relación con el respeto de los derechos y valores individuales y colectivos, lo que permite enfrentar las dificultades en el ejercicio de la función pública.

Abstract: Energy consumption in cloud datacenters is an alarming issue in recent times. Although handful of researches have been conducted in this domain during virtual machine placement in cloud milieu, efficient techniques are still scarce. Hence, we have worked on a novel approach to propose a hybrid metaheuristic technique combining the salp swarm optimization and emperor penguins colony algorithm, i.e. SSEPC to place the virtual machines in the most suitable datacenters as well as servers in a cloud environment, while optimizing the energy consumption. The method we propose has been compared with certain relevant hybrid algorithms in this direction like Sine Cosine Algorithm and Salp Swarm Algorithm (SCA-SSA), Genetic Algorithm and Tabu-search Algorithm (GATA), and Order Exchange & Migration algorithm and Ant Colony System algorithm (OEMACS) to test its efficacy. It is found that proposed SSEPC is consuming 4.4%, 8.2%, and 16.6% less energy as compared to its counterparts GATA, OEMACS, and SCA-SSA respectively.

RESUMEN Introducción: Las opciones de tratamiento para la hidrocefalia relacionada con tumores de fosa posterior han sido ampliamente estudiadas en la población pediátrica, pero es controvertido el valor de la tercer ventriculostomía endoscópica, en la hidrocefalia secundaria a schwanoma vestibular en adultos, previo a la resección del tumor. Se realizó una búsqueda sistemática de la literatura médica en Pubmed/Medline y SciElo para la identificación e inclusión de artículos, además de los servidores de preprint bioRxiv y medRxiv. Se utilizaron los siguientes descriptores: “hydrocephalus” y “vestibular schwannomas” o “acoustic neuromas” o “acoustic neurinomas” y “endoscopic third ventriculostomy”. La búsqueda inicial encontró 195 artículos. Después de la selección, se eligieron 5 artículos para el estudio. Objetivo: Especificar el papel de la tercer ventriculostomía endoscópica en la hidrocefalia secundaria a schwanomas vestibulares. Desarrollo: Los artículos incluyeron un total de 82 pacientes, en los que se logró una mejoría de los síntomas en el 86,6 % de los casos. La disminución del diámetro ventricular se reportó en el 82,9 % de los casos y solo se encontró explícita en 3 artículos. Aunque los criterios de fracaso utilizados fueron variados, predominaron dos de ellos: la persistencia de hidrocefalia sintomática progresiva o la necesidad de colocación de derivación. La falla de la tercer ventriculostomía endoscópica solo representó el 14,6 %. Conclusiones: La tercera ventriculostomía endoscópica es una técnica aceptable y con relativo éxito para el tratamiento de la hidrocefalia obstructiva sintomática secundaria a schwanomas vestibulares.

ABSTRACT Introduction: Treatment options for hydrocephalus related to posterior fossa tumors have been extensively studied in the pediatric population, but the value of endoscopic third ventriculostomy in hydrocephalus secondary to vestibular schwannoma in adults, is controversial. A systematic search of the medical literature was carried out in Pubmed/Medline and SciElo for the identification and inclusion of articles, in addition to the preprint servers bioRxiv and medRxiv. The following descriptors were used: “hydrocephalus” and “vestibular schwannomas” or “acoustic neuromas” or “acoustic neurinomas” and “endoscopic third ventriculostomy”. The initial search found 195 articles. After selection, 5 articles were chosen for the study. Objective: To specify the role of the endoscopic third ventriculostomy in hydrocephalus secondary to vestibular schwannomas. Development: The articles included a total of 82 patients, in which an improvement of the symptoms was achieved in 86.6% of the cases. The decrease in ventricular diameter was reported in 82.9% of the cases and was only found explicit in 3 articles. Although the failure criteria used were varied, 2 of them predominated: the persistence of progressive symptomatic hydrocephalus and/or the need for shunt placement. Endoscopic third ventriculostomy failure only represented 14.6%. Conclusions: Third ventriculostomy is an acceptable technique with relative success for the treatment of symptomatic obstructive hydrocephalus secondary to vestibular schwannomas.

RESUMEN Introducción: Los schwanomas vestibulares son lesiones clasificadas como grado I por la Organización Mundial de la Salud. Las opciones conductuales incluyen la observación, la radiocirugía o la resección microquirúrgica endoscópica. Objetivo: Describir el rol del tratamiento multimodal en los schwanomas vestibulares. Métodos: Se realizó una búsqueda sistemática de literatura médica para la identificación e inclusión de artículos en las siguientes bases de datos: PubMed/Medline, SciELO y Google Scholar, además de los servidores de preprints BioRvix y MedRvix. Se usaron los siguientes descriptores: vestibular schwanoma OR acoustic neuroma AND nerve centered approach OR combined approach AND partial resection OR subtotal resection OR near total resection. Se excluyeron editoriales, cartas al editor, libros, revisiones, metaanálisis y aquellos artículos con método deficiente de más de 20 años de publicación o sin mención al tema de interés. Fueron incluidos 16 artículos. Desarrollo: Los artículos incluyeron un total de 699 pacientes, de los cuales solo 228 (32,6 %) recibieron radioterapia en el período posoperatorio. El período de seguimiento promedió 49,6 meses. La preservación de la función facial se logró en el 88,3 % de los casos y el control tumoral en el 80,7 %. El estado de la preservación auditiva solo fue informado en el 50 % de los estudios. El uso de la radioterapia adyuvante mostró gran variabilidad. Conclusiones: El tratamiento multimodal para los schwanomas vestibulares grandes -compuesto por la resección subtotal, vaciamiento intratumoral, seguido de radiocirugía- se ha convertido en una opción plausible. Se necesita la publicación de mayor cantidad de reportes para ofrecer recomendaciones y estratificar la conducta.

ABSTRACT Introduction: Vestibular schwannomas are lesions classified as grade I by the World Health Organization. Behavioral options include observation, radiosurgery or endoscopic microsurgical resection. Objective: To describe the role of multimodal treatment for vestibular schwannomas. Methods: A systematic search of medical literature, for the identification and inclusion of articles, was carried out in the databases PubMed/Medline, SciELO and Google Scholar, as well as in the preprint servers BioRvix and MedRvix. The following descriptors were used: vestibular schwannoma OR acoustic neuroma AND nerve centered approach OR combined approach AND partial resection OR subtotal resection OR near total resection. Editorials, letters to the editor, books, reviews and metaanalyses were excluded, as well as articles with deficient method of more than 20 years of publication or not mentioning the topic of interest. Sixteen articles were included. Development: The articles included a total of 699 patients, of which only 228 (32.6 %) received radiotherapy in the postoperative period. The average follow-up period was 49.6 months. Preservation of facial function was achieved in 88.3 % of cases; and tumor control, in 80.7 %. Hearing preservation status was reported in only 50 % of the studies. The usage of adjuvant radiotherapy showed great variability. Conclusions: Multimodal treatment for large vestibular schwannomas -composed of subtotal resection and intratumoral draining, followed by radiosurgery- has become a plausible option. The publication of a greater amount of reports is necessary to provide recommendations and stratify the behavior.

ABSTRACT The objective of this review article is to determine, through a database, the level of the work climate of health personnel from public institutions in Latin America, generated through scientific publications from 2019 to 2022. The research is of descriptive quantitative character. A total of 1,069,976 articles found were obtained, leaving 12 articles through systematic purification as the final result. The results of this article show that, at the Latin American level, in eight of them (three from Mexico, two from Peru, two from Ecuador and one from Brazil) health professionals perceive an inadequate work environment, unlike the four remaining investigations (one from Brazil, Colombia, Venezuela and Chile) that perceive an optimal work environment. And the factors that affect the work environment in health personnel as identified public servants are, in the first place, the remuneration factor, inadequate decision making, lack of leadership, lack of recognition and outstanding achievements.

RESUMEN El presente artículo de revisión tiene como objetivo determinar a través de una base de datos el nivel del clima laboral del personal de salud de las instituciones públicas en Latinoamérica, generados a través de las publicaciones científicas del año 2019 hasta el 2022. La investigación es de carácter cuantitativa descriptiva. Se obtuvo un total de 1,069,976 artículos encontrados, quedando con 12 artículos mediante una depuración sistemática como resultado final. Los resultados del presente artículo muestran que, a nivel de Latinoamérica, en ocho de ellos (tres de México, dos de Perú, dos de Ecuador y uno de Brasil) los profesionales de la salud perciben un clima laboral inadecuado, a diferencia de las cuatro investigaciones restantes (uno de Brasil, Colombia, Venezuela y Chile) que perciben un clima laboral óptimo. Y los factores que afectan el clima laboral en el personal de salud como servidores públicos identificados son en primer lugar el factor remunerativo, toma de decisiones inadecuadas, falta de liderazgo, falta de reconocimientos y logros destacados.

Abstract: Mobile cloud computing is currently an encouraging field in the cyber-physical world. It is an amalgamation of mobile computing and cloud computing. Computational offloading is one feature in the mobile cloud application that offloads the task to the cloud server, processes it, and gets the results back on the mobile device. During offload, the job needs to be queued on the cloud servers and allocated to the virtual machines. Task scheduling is an important step where the mobile task is assigned to the servers and processed somehow. In the overall offloading process, energy conservation is a significant concern. The scheduling problem involves mapping the offloaded task to the cloud server while satisfying the energy and time constraints. This paper proposes a hybrid scheduling scheme based on Gaussian-based multi-objective particle swarm optimization(GMOPSO) and bacterial foraging optimization(BFO). This scheme performs better when compared to other variants of PSO in terms of makespan and energy efficiency.

This study aims to describe how the advanced campus of Patos de Minas (CPM) of the Federal University of Uberlândia (UFU) is managed, identify and analyze the positive and negative aspects of the administrative management model adopted. This is a qualitative study developed from semi-structured interviews with servers with experience in university management, and online sessions that obtained 298 participants (45.78% of the CPM faculty, students and technicians). The research followed Bardin's content analysis guidelines. As a result, it was concluded that the CPM presents a bureaucratic administrative management, but with elements of the political model in its decision-making processes. The main positive points are the good relationship and dialogue between the CPM and the headquarters and among the negative aspects are the low autonomy and high centralization in the management of the Patos de Minas campus. Among the main recommendations for improvement pointed out by the study, the following stand out: bringing the decision-making structure closer to the student, increasing the decision-making power of local managers, formalizing a policy of good relationship between the advanced campus and the headquarters, and making administrative management more flexible.

Este estudio tiene como objetivo describir cómo se gestiona el campus avanzado de Patos de Minas (CPM) de la Universidad Federal de Uberlândia (UFU), para identificar y analizar las fortalezas y debilidades del modelo de gestión administrativa adoptado. Se trata de un estudio cualitativo desarrollado a partir de entrevistas semiestructuradas a funcionarios, con experiencia en gestión universitaria, y cuestionarios online que obtuvieron 298 participantes (45,78% del profesorado, estudiantes y técnicos del CPM). La investigación siguió las pautas de análisis de contenido de Bardin. Como resultado, se concluyó que el CPM presenta una gestión administrativa mayoritariamente burocrática, pero con fuertes elementos del modelo político en sus procesos de toma de decisiones. Las principales fortalezas involucran la buena relación y diálogo entre el CPM y la sede y entre los puntos negativos se destaca la baja autonomía y alta centralización en la gestión del campus de Patos de Minas. Entre las principales recomendaciones de mejora señaladas por el estudio destacan: acercar la estructura de toma de decisiones al alumno, incrementar el poder de decisión de los gestores locales, formalizar una política de buena relación entre el campus avanzado y el sede y flexibilización de la gestión administrativa.

Este estudo visa descrever como é administrado o campus avançado de Patos de Minas (CPM) da Universidade Federal de Uberlândia (UFU) e analisar os aspectos positivos e negativos do modelo de gestão administrativa adotado. Trata-se de um estudo qualitativo desenvolvido a partir de entrevistas semiestruturadas com servidores, com experiência em gestão universitária, e questionários online que obteve 298 participantes (45,78% do corpo docente, discente e técnico do CPM). A pesquisa observou as diretrizes da análise de conteúdo de Bardin. Como resultados, concluiu-se que o CPM apresenta uma gestão administrativa burocrática, mas com elementos do modelo político em seus processos de tomada de decisão. Os principais aspectos positivos envolvem o bom relacionamento e diálogo entre o CPM e a sede e entre os aspectos negativos destacam-se a baixa autonomia e elevada centralização na gestão do campus Patos de Minas. Dentre as principais recomendações de melhoria apontadas pelo estudo, destacam-se: aproximar a estrutura decisória do estudante, aumentar o poder de decisão dos gestores locais, formalizar política de bom relacionamento entre o campus avançado e a sede e flexibilizar a gestão administrativa.

ABSTRACT Purpose: This study analyzes the effects of organizational justice on the performance of tasks in the justice sector, divided by activity and position. Design/methodology/approach: We applied structural equations to a sample of 474 employees of the Public Prosecutor. Findings: A direct and positive effect of distributive justice and interactional justice on task performance was discovered. However, aspects of procedural justice do not have a significant relationship with task performance. The performance of non-core activities is positively influenced by interactional justice and the final activity by distributive justice. As for the positions, the interactional dimension has a significant magnitude in the position of analyst, while the distributive and procedural justice affect the performance of the technician's positions. Practical implications: These findings provide an understanding of how organizations can build their organizational structure between middle and end activities, to increase the perception of justice of their servers, and consequently improving the performance of activities. Originality: The article explores in an unprecedented way the perception of organizational justice in different work functions - the core activity and the non-core activity. Purpose sector Design/methodology/approach Designmethodologyapproach Design methodology approach 47 Prosecutor Findings discovered However noncore non positions analyst technicians technician s implications servers Originality 4

RESUMO Objetivo: Este estudo analisa os efeitos da justiça organizacional no desempenho das tarefas do setor de justiça, segmentados pelo tipo de atividade e cargo. Desenho/metodologia/abordagem: Aplicou-se a análise por equações estruturais a uma amostra de 474 funcionários do Ministério Público. Resultados: Foi descoberto um efeito direto e positivo da justiça distributiva e da justiça interacional no desempenho da tarefa. No entanto, os aspectos da justiça processual não têm uma relação significativa com o desempenho da tarefa. O desempenho das atividades meio ou administrativas é influenciado positivamente pela justiça interacional enquanto o servidor em atividade finalística pela justiça distributiva. Quanto aos cargos, a dimensão interacional tem uma magnitude significativa no cargo de analista, enquanto a justiça distributiva e processual afetam o desempenho dos cargos de técnico. Implicações práticas: Esses achados proporcionam uma compreensão de como as organizações podem construir sua estrutura organizacional entre atividades intermediárias e finais, com vistas a aumentar a percepção de justiça de seus servidores e, consequentemente, melhorar o desempenho das atividades. Originalidade: O artigo explora de forma inédita a percepção de justiça organizacional em distintas funções laborais - a atividade fim e a atividade meio. Objetivo Desenho/metodologia/abordagem Desenhometodologiaabordagem Desenho metodologia abordagem Aplicouse Aplicou se 47 Público Resultados tarefa entanto analista técnico práticas finais consequentemente Originalidade 4