RESUMEN Introducción: las enfermedades del pie relacionadas a la diabetes mellitus representan una de las causas de mayor morbilidad e incapacidad en las personas con diabetes mellitus tipo 2, siendo la causa más frecuente de ingreso hospitalario en dicho grupo. Objetivo: describir las características clínicas de los pacientes con enfermedad del pie relacionadas a la diabetes mellitus del Hospital Nacional 2022-2023. Metodología: se seleccionaron 113 pacientes portadores de diabetes mellitus tipo 2 con pie diabético mayores de 18 años. Se evaluaron las variables demográficas, medidas antropométricas, características de la enfermedad, comorbilidades y características clínicas del pie. Resultados: de los 113 estudiados 42 pacientes (37 %) correspondieron al sexo femenino y 71 (63 %) al sexo masculino, promedio de edad fue de 65 años DE 12,191. 75 pacientes (66 %) presentaron pie diabético, con lesión Wagner grado 4. El 81 % (92) tenía hipertensión arterial, sedentarismo 65 % (84), en menor frecuencia pacientes con sobrepeso 38 % (43), obesidad 25 % (38), tabaquismo 23 % (26) y dislipidemia 18 % (20). Conclusión: las características clínicas de los pacientes con diabetes tipo 2 con lesión en el pie coinciden con otros trabajos obtenidos a nivel mundial. Es muy importante prestar atención a este grupo de riesgo, mediante medidas preventivas y realizar el tratamiento precoz para disminuir las complicaciones.

ABSTRACT Introduction: foot diseases related to diabetes mellitus represent one of the causes of greatest morbidity and disability in people with type 2 diabetes mellitus, being the most frequent cause of hospital admission in said group. Objective: to describe the clinical characteristics of patients with foot disease related to diabetes mellitus at Hospital Nacional 2022-2023. Methodology: 113 patients with type 2 diabetes mellitus with diabetic foot over 18 years of age were selected. Demographic variables, anthropometric measurements, disease characteristics, comorbidities, and clinical characteristics of the foot were evaluated. Results: of the 113 studied, 42 patients (37 %) were female and 71 (63 %) were male, average age was 65 years SD 12,191. 75 patients (66 %) presented diabetic foot, with Wagner grade 4 lesion. 81 % (92) had high blood pressure, sedentary lifestyle 65 % (84), less frequently overweight patients 38 % (43), obesity 25% (38) ), smoking 23 % (26) and dyslipidemia 18 % (20). Conclusion: the clinical characteristics of patients with type 2 diabetes with foot injury coincide with other works obtained worldwide. It is very important to pay attention to this risk group, through preventive measures and carry out early treatment to reduce complications.

ABSTRACT Foundation: acute coronary syndromes constitute a health problem due to their high morbidity and mortality. It would be reasonable to assume that health workers take care of and control their own coronary risk factors, however, research results show that this is not always the case. Objective: to characterize coronary risk factors in workers at the Guillermo Domínguez López General Teaching Hospital in Las Tunas. Method: a descriptive cross-sectional study was carried out at the Guillermo Domínguez López General Teaching Hospital in Las Tunas between December 2019 and December 2022. The study population was 912 workers and the sample was 200. It was a probabilistic, simple random sampling divided into two groups: A (with acute coronary syndrome) and B (without acute coronary syndrome). The following variables were analyzed: age, sex, coronary risk factors. The information was obtained from clinical records and analyzed in percentage, mean, standard deviation and the z statistic to obtain the influence of risk factors on the disease. Results: the average age of group A: 56.5 (±5.03), group B: 46.4 (±11.33) years with a predominance of the male sex (54.5 %). The predominant risk factors were: sedentary lifestyle (57 %), smoking (36.5 %) and high blood pressure (34 %). Those with the greatest influence were: a history of ischemic heart disease, vascular disease, abdominal obesity (z: 0.99), diabetes mellitus (z: 0.92) and arterial hypertension (z: 0.70). Conclusions: coronary syndrome predominates in the fifth decade of life and is more common in males.

RESUMEN Fundamento: los síndromes coronarios agudos constituyen un problema de salud debido a su alta morbilidad y mortalidad. Sería razonable asumir que los trabajadores de la salud cuidan y controlan sus propios factores de riesgo coronario, no obstante, los resultados obtenidos en investigaciones muestran que no siempre es así. Objetivo: caracterizar los factores de riesgo coronario en trabajadores del Hospital General Docente Guillermo Domínguez López de Las Tunas. Método: se realizó un estudio descriptivo de corte transversal en el Hospital General Docente Guillermo Domínguez López de Las Tunas entre diciembre de 2019 y diciembre de 2022. La población de estudio fue de 912 trabajadores y la muestra de 200. Fue un muestreo probabilístico, aleatorio simple, dividido en dos grupos: A (con síndrome coronario agudo) y B (sin síndrome coronario agudo). Se analizaron las siguientes variables: edad, sexo, factores de riesgo coronario. La información se obtuvo de expedientes clínicos y se analizó en porcentaje, media, desviación estándar y el estadígrafo z para obtener la influencia de los factores de riesgo en la enfermedad. Resultados: la media de edad del grupo A: 56,5 (±5,03), grupo B: 46,4 (±11,33) años con predominio del sexo masculino (54,5 %). Los factores de riesgo que predominaron fueron: sedentarismo (57 %), tabaquismo (36,5 %) e hipertensión arterial (34 %). Los de mayor influencia fueron: los antecedentes de cardiopatía isquémica, la enfermedad vascular, la obesidad abdominal (z: 0,99), la diabetes mellitus (z: 0,92) y la hipertensión arterial (z: 0,70). Conclusiones: el síndrome coronario predomina en la quinta década de la vida y con mayor frecuencia en el sexo masculino.

SUMMARY: To take advantage of altitude, "intermittent hypoxia" methods have been developed that involve shorter exposures to hypoxia. In general, systemic hypoxia can be produced in two ways: (1) by lowering barometric pressure (BP, hypobaric hypoxia) or (2) by reducing the amount of oxygen in inspired air (FiO2) through oxygen filtration or nitrogen dilution (normobaric hypoxia). The objective of this analysis was to observe changes in body composition and aerobic performance after 8 weeks of intermittent hypoxia exposure at rest. A total of 20 male volunteers between the ages of 18-26 participated in the study. Participants were randomly divided into 2 groups (Control Group and Intermittent Hypoxia Group). The Intermittent Hypoxia Group completed the process by being exposed to intermittent hypoxia for 8 weeks. Each intermittent hypoxia session was planned as 3 days a week and for 1 hour. After 8 weeks of experimental process, statistically significant differences were found for lean mass, android lean mass, gynoid lean mass, the relative skeletal muscle mass index, peak lactate, 1mmol lactate threshold, 4mmol lactate threshold, and MaxVo2 variables (p<0,05). After 8 weeks of intermittent hypoxia exposure, an increase in maximal oxygen consumption capacity was observed. The increase in lean mass, especially in the gynoid and android regions, can be explained by the increase in fat burning activities due to oxygen utilization capacity. Almost every study reviewed in the literature used different intermittent hypoxia exposure protocols and different simulated altitudes. The method discussed in this study may be beneficial on the body composition and oxygen utilization capacity of sedentary individuals.

RESUMEN: Para aprovechar la altitud, se han desarrollado métodos de «hipoxia intermitente» que implican exposiciones más cortas a la hipoxia. En general, la hipoxia sistémica se puede producir de dos maneras: (1) reduciendo la presión barométrica (PA, hipoxia hipobárica) o (2) reduciendo la cantidad de oxígeno en el aire inspirado (FiO2) mediante filtración de oxígeno o dilución de nitrógeno (hipoxia normobárica). El objetivo de este análisis fue observar cambios en la composición corporal y el rendimiento aeróbico después de 8 semanas de exposición intermitente a hipoxia en reposo. Participaron en el estudio un total de 20 voluntarios varones de entre 18 y 26 años. Los participantes se dividieron aleatoriamente en 2 grupos (grupo control y grupo hipoxia intermitente). El grupo de hipoxia intermitente completó el proceso al estar expuesto a hipoxia intermitente durante 8 semanas. Cada sesión de hipoxia intermitente se planificó 3 días a la semana y durante 1 hora. Después de 8 semanas de proceso experimental, se encontraron diferencias estadísticamente significativas para la masa magra, la masa magra androide, la masa magra ginoide, el índice de masa muscular esquelético relativo, el pico de lactato, el umbral de lactato de 1 mmol, el umbral de lactato de 4 mmol y las variables MaxVo2 (p< 0,05). Después de 8 semanas de exposición intermitente a hipoxia, se observó un aumento en la capacidad máxima de consumo de oxígeno. El aumento de la masa magra, especialmente en las regiones ginoidea y androide, puede explicarse por el aumento de las actividades de quema de grasa debido a la capacidad de utilización de oxígeno. Casi todos los estudios revisados en la literatura utilizaron diferentes protocolos de exposición intermitente a la hipoxia y diferentes altitudes simuladas. El método analizado en este estudio puede ser beneficioso para la composición corporal y la capacidad de utilización de oxígeno de personas sedentarias.

ABSTRACT BACKGROUND: Research on the economic burden of sedentary behavior and abdominal obesity on health expenses associated with cardiovascular diseases is scarce. OBJECTIVE: The objective of this study was to verify whether sedentary behavior, isolated and combined with abdominal obesity, influences the medication expenditure among adults with cardiovascular diseases. DESIGN AND SETTING: This cross-sectional study was conducted in the city of President Prudente, State of São Paulo, Brazil in 2018. METHODS: The study included adults with cardiovascular diseases, aged 30-65 years, who were treated by the Brazilian National Health Services. Sedentary behavior was assessed using a questionnaire. Abdominal obesity was defined by waist circumference. Medication expenditures were verified using the medical records of each patient. RESULTS: The study included a total of 307 adults. Individuals classified in the group with risk factor obesity combined (median [IQ] USD$ 29.39 [45.77]) or isolated (median [IQ] USD$ 27.17 [59.76]) to sedentary behavior had higher medication expenditures than those belonging to the non-obese with low sedentary behavior group (median [IQ] USD$ 13.51 [31.42]) (P = 0.01). The group with combined obesity and sedentary behavior was 2.4 (95%CI = 1.00; 5.79) times more likely to be hypertensive. CONCLUSION: Abdominal obesity was a determining factor for medication expenses, regardless of sedentary behavior, among adults with cardiovascular diseases. BACKGROUND scarce OBJECTIVE SETTING crosssectional cross sectional Prudente Paulo 2018 METHODS 3065 30 65 30-6 years Services questionnaire circumference patient RESULTS median IQ [IQ USD 2939 29 39 29.3 45.77 4577 45 77 [45.77] 2717 27 17 27.1 59.76 5976 59 76 [59.76] nonobese non obese 1351 13 51 13.5 31.42 3142 31 42 [31.42] P 0.01. 001 0.01 . 0 01 0.01) 24 2 4 2. 95%CI 95CI CI 95 1.00 100 1 00 5.79 579 5 79 hypertensive CONCLUSION 201 306 3 6 30- 293 29. 45.7 457 7 [45.77 271 27. 59.7 597 [59.76 135 13. 31.4 314 [31.42 0.0 9 1.0 10 5.7 57 20 45. [45.7 59. [59.7 31. [31.4 0. 1. 5. [45. [59. [31. [45 [59 [31 [4 [5 [3 [

RESUMEN Introducción: La artrosis (OA) es una enfermedad inflamatoria degenerativa crónica, caracterizada por la degeneración progresiva del cartílago articular, que afecta principalmente a la articulación de la rodilla. La población anciana es la más afectada, intensificándose el proceso de envejecimiento. La concentración de tejido adiposo intramuscular en los músculos del muslo y la OA de rodilla a diferentes edades sigue siendo objeto de investigación. Objetivo: Investigar el área transversal de los músculos del muslo a diferentes edades con la relación de la presencia de grasa intramuscular y la OA de rodilla. Métodos: Se emparejó a 80 participantes en 4 grupos: Grupo de jóvenes con osteoartritis y Grupo de mayores con osteoartritis, ambos sedentarios y con diagnóstico de OA de rodilla II o III; Grupo de jóvenes sanos y Grupo de mayores sanos, ambos sanos y sedentarios. Los grupos fueron emparejados según sexo e índice de masa corporal, sometidos a evaluación fisioterapéutica, cuestionario WOMAC, exámenes radiográficos de las rodillas y tomografía computarizada del muslo. El análisis morfométrico se realizó manualmente con el software ITK-SNAP (versión 3.6), por un único evaluador. En el análisis estadístico se utilizó la prueba ANOVA unidireccional seguida del post-hoc de Bonferroni para las variables dependientes (p≤0,05). Resultados: La comparación del área transversal de los músculos recto femoral, vasto lateral, semitendinoso, sartorio y gracilis entre los grupos no indicó diferencias significativas (p>0,05). El estudio de la atenuación para el tejido adiposo muscular no indicó diferencias significativas en los valores de entre los grupos OA-Young y Aged-S para todos los músculos evaluados. Conclusión: Individuos jóvenes con OA de rodilla presentan características morfológicas musculares similares a las encontradas durante el proceso de envejecimiento, caracterizando el envejecimiento precoz de los músculos del muslo. Nivel de Evidencia III; Estudio transversal y observacional retrospectivo. Introducción (OA crónica articular afectada investigación Objetivo Métodos 8 III corporal fisioterapéutica WOMAC ITKSNAP ITK SNAP versión 3.6, 36 3.6 , 3 6 3.6) evaluador posthoc post hoc p≤0,05. p005 p p≤0,05 . 0 05 (p≤0,05) Resultados femoral lateral semitendinoso p>0,05. p>0,05 (p>0,05) OAYoung Young AgedS Aged S evaluados Conclusión retrospectivo 3. p00 p≤0,0 (p≤0,05 p>0,0 (p>0,05 p0 p≤0, (p≤0,0 p>0, (p>0,0 p≤0 (p≤0, p>0 (p>0, p≤ (p≤0 p> (p>0 (p≤ (p> (p

ABSTRACT Introduction: Osteoarthritis (OA) is a chronic inflammatory degenerative disease, characterized by progressive degeneration of the articular cartilage, affecting mostly the knee joint. The elderly population is the most affected, intensifying the aging process. The concentration of intramuscular adipose tissue in the thigh muscles and knee OA at different ages remains under investigation. Objective: Investigate the cross-sectional area of thigh muscles at different ages with the relationship of the presence of intramuscular fat and knee OA. Methods: 80 participants were paired into 4 groups: Young Osteoarthritis Group and Old Osteoarthritis Group, both sedentary with knee OA diagnosis II or III; Healthy Young Group and Healthy Old Group, both healthy and sedentary. The groups were paired according to gender and body mass index, submitted to physiotherapeutic evaluation, WOMAC questionnaire, knee X-ray and thigh CT scans. Morphometric analysis was performed manually with ITK-SNAP software (version 3.6), by a single evaluator. Statistical analysis used the one-way ANOVA test followed by Bonferroni post-hoc for dependent variables (p≤0.05). Results: Comparison of the cross-sectional area of the rectus femoris, vastus lateralis, semitendinosus, sartorius and gracilis muscles between the groups indicated no significant differences (p>0.05). The study of attenuation for muscle adipose tissue indicated no significant difference in the values of between the OA-Young and Aged-S groups for all the muscles evaluated. Conclusion: Young individuals with knee OA present muscle morphological characteristics similar to those found during the aging process, characterizing early aging of the thigh muscles. Level of Evidence III; Retrospective cross-sectional and observational study. Introduction (OA disease cartilage joint affected process investigation Objective crosssectional cross sectional Methods 8 III index evaluation questionnaire Xray X ray scans ITKSNAP ITK SNAP version 3.6, 36 3.6 , 3 6 3.6) evaluator oneway one way posthoc post hoc p≤0.05. p005 p p≤0.05 . 0 05 (p≤0.05) Results femoris lateralis semitendinosus p>0.05. p>0.05 (p>0.05) OAYoung AgedS Aged S evaluated Conclusion 3. p00 p≤0.0 (p≤0.05 p>0.0 (p>0.05 p0 p≤0. (p≤0.0 p>0. (p>0.0 p≤0 (p≤0. p>0 (p>0. p≤ (p≤0 p> (p>0 (p≤ (p> (p

RESUMO Introdução: A osteoartrite (OA) é uma doença inflamatória crônico-degenerativa, caracterizada pela degeneração progressiva da cartilagem articular, acometendo em maior parte a articulação do joelho. A população idosa é a mais atingida, intensificando o processo de envelhecimento. A concentração de tecido adiposo intramuscular nos músculos da coxa e a OA de joelho em diferentes idades permanece em investigação. Objetivo: Investigar a área de secção transversa dos músculos da coxa em diferentes idades com a relação da presença de gordura intramuscular e OA de joelho. Métodos: 80 participantes foram pareados em 4 grupos: Grupo Osteoartrite Jovem e Grupo Osteoartrite Idoso, ambos sedentários com diagnóstico de OA de joelho II ou III; Grupo Jovem Saudável e Grupo Idoso Saudável, ambos saudáveis e sedentários. Os grupos foram pareados de acordo com sexo e índice de massa corporal, submetidos à avaliação fisioterapêutica, questionário WOMAC, exames de raio-x dos joelhos e tomografia computadorizada da coxa. A análise morfométrica foi realizada manualmente com software ITK-SNAP (versão 3.6), por um único avaliador. Análise estatística utilizou o teste ANOVA one-way seguido pelo post-hoc de Bonferroni, para variáveis dependentes (p≤0,05). Resultados: A comparação da área de secção transversa dos músculos reto femoral, vasto lateral, semitendinoso, sartório e grácil, entre os grupos, não indicou diferenças significativas (p>0,05). O estudo da atenuação para o tecido adiposo muscular não indicou diferença significativa nos valores de entre os grupos OA-Jovem e Idoso-S para todos os músculos avaliados. Conclusão: Indivíduos jovens com OA de joelho apresentam características morfológicas musculares semelhantes às encontradas durante o processo de envelhecimento, caracterizando um envelhecimento precoce dos músculos da coxa.Nível de Evidência III; Estudo retrospectivo transversal e observacional. Introdução (OA crônicodegenerativa, crônicodegenerativa crônico degenerativa, degenerativa crônico-degenerativa articular atingida investigação Objetivo Métodos 8 III corporal fisioterapêutica WOMAC raiox raio x ITKSNAP ITK SNAP versão 3.6, 36 3.6 , 3 6 3.6) avaliador oneway one way posthoc post hoc Bonferroni p≤0,05. p005 p p≤0,05 . 0 05 (p≤0,05) Resultados femoral lateral semitendinoso grácil p>0,05. p>0,05 (p>0,05) OAJovem IdosoS S avaliados Conclusão coxaNível Nível observacional 3. p00 p≤0,0 (p≤0,05 p>0,0 (p>0,05 p0 p≤0, (p≤0,0 p>0, (p>0,0 p≤0 (p≤0, p>0 (p>0, p≤ (p≤0 p> (p>0 (p≤ (p> (p

Abstract The aim of the present study was to analyze the relationship between time spent engaged in sedentary behaviors, type of diet, and overweight in adolescents. A cross-sectional study using data from the Longitudinal Study on Sedentary Behavior, Physical Activity, Eating Habits, and Health of Adolescents - LONCAAFS Study. A total of 1,438 adolescents (10 to 14 years old) from public schools in the city of João Pessoa, Brazil, participated in the study. To evaluate the combined effects of excessive time in sedentary behavior and consumption from two food groups: Convenience and Prudent on overweight, we performed multiple logistic regression analyses, adjusted for energy, level of physical activity, sex, and age. Excessive time in sedentary behavior increased the chance of adolescents being overweight by 37% (OR = 1.37; 95%CI: 1.04-1.80). This chance increased to 43% when the adolescents were simultaneously engaged in excessive sedentary behavior and had high consumption of the Convenience food group (OR = 1.43; 95%CI: 1.05-1.94) and increased to 39% on those who engaged in excessive sedentary behavior and had low consumption of foods from the Prudent (OR = 1.39; 95%CI: 1.04-1.84). Excessive sedentary behavior is associated with being overweight and the chance increases with the consumption of convenient foods.

Resumo O objetivo do estudo foi analisar a relação entre tempo gasto em comportamentos sedentários, dieta e excesso de peso em adolescentes. Estudo transversal com dados do Estudo Longitudinal sobre Comportamento Sedentário, Atividade Física, Hábitos Alimentares e Saúde do Adolescente - Estudo LONCAAFS. Participaram 1.438 adolescentes (10 a 14 anos) de escolas públicas de João Pessoa, Brasil. Para avaliar os efeitos combinados do tempo excessivo no comportamento sedentário e no consumo de dois grupos de alimentos: Conveniência e Prudente sobre o excesso de peso, foram realizadas análises de regressão logística múltipla, ajustadas para energia, nível de atividade física, sexo e idade. O tempo excessivo em comportamento sedentário aumentou em 37% a chance de os adolescentes apresentarem excesso de peso (OR = 1,37; IC95%: 1,04-1,80). Essa chance aumentou para 43% quando os adolescentes apresentaram, simultaneamente, comportamento sedentário excessivo e alto consumo do grupo de alimentos de conveniência (OR = 1,43; IC95%: 1,05-1,94), e aumentou para 39% naqueles com excesso de comportamento sedentário e baixo consumo de alimentos do Prudente (OR = 1,39; IC95%: 1,04-1,84). O comportamento sedentário excessivo está associado ao excesso de peso e a chance aumenta com o consumo de alimentos convenientes.

Abstract: This study aimed to investigate the association between sociodemographic and behavioral factors and obesity from 2014 to 2021 in adults in São Paulo city, Brazil. A prospective study was carried out with 1,241 adults aged 18 years or above who lived in São Paulo and participated in the São Paulo Health Survey cohort (ISA) - Physical Activity and Environment. The outcome was obesity (yes/no), classified by body mass index and specific cut-off points for each age group. The exposure variables included sex, age, education, skin color, marital status, regional health coordination, physical activity in the four domains, and sedentary behaviors. Multilevel logistic regression models were used for longitudinal analysis. This study found a significant increase (27.7%) in the prevalence of obesity (from 22.6% to 28.9%). People who practiced at least 150 minutes of leisure-time physical activity per week (OR = 0.44; 95%CI: 0.26; 0.76), between 10 and 150 minutes per week of commuting physical activity (OR = 0.49; 95%CI: 0.30; 0.80), and had no partner (OR = 0.47; 95%CI: 0.28; 0.78) were less likely to be obese. People aged from 40 to 59 years (OR = 5.00; 95%CI: 2.02; 12.38) and who were black (OR = 4.70; 95%CI: 1.85; 11.95) were more likely to be obese. This study found an increase in the prevalence of obesity during the studied period, with increased odds for middle-aged and black people and decreased odds for those without a partner and those who practice physical activities in their leisure and as a form of commuting. These results can contribute to support programs and policies to control obesity.

Resumen: El objetivo fue investigar la asociación entre factores sociodemográficos y conductuales y la presencia de la obesidad entre 2014 y 2021 en adultos de la ciudad de São Paulo, Brasil. Se realizó un estudio prospectivo con 1.241 adultos paulistanos, con 18 años o más, participantes de la cohorte Encuesta de Salud de São Paulo (ISA) - Actividad Física y Ambiente. El resultado fue obesidad (sí/no), clasificada a través del índice de masa corporal y con puntos de corte específicos para cada grupo de edad. Las variables de exposición fueron: sexo, edad, escolaridad, color de la piel, estado civil, coordinación regional de salud, actividad física en los cuatro dominios y comportamientos sedentarios. Para los análisis longitudinales se utilizaron modelos de regresión logística multinivel. Hubo un aumento significativo del 27,7% en la prevalencia de la obesidad (del 22,6% al 28,9%). Las personas que practicaron al menos 150 minutos semanales de actividad física por ocio (OR = 0,44; IC95%: 0,26; 0,76), entre 10 y 150 minutos semanales de actividad física de desplazamiento (OR = 0,49; IC95%: 0,30; 0,80) y sin compañero(a) (OR = 0,47; IC95%: 0,28; 0,78) tuvieron menos probabilidades de tener obesidad. Las personas entre 40 y 59 años (OR = 5,00; IC95%: 2,02; 12,38) y de color de piel negra (OR = 4,70; IC95%: 1,85; 11,95) presentaron mayores probabilidades de tener obesidad. El estudio identificó un aumento en la prevalencia de la obesidad durante ese período, con un aumento en las posibilidades para las personas de mediana edad y color de la piel negra, y una disminución en las posibilidades para las personas que viven sin pareja y para las que realizan actividades físicas por ocio y como forma de desplazamiento. Estos resultados pueden contribuir a apoyar los programas y políticas para el control de la obesidad.

Resumo: O objetivo foi investigar a associação entre fatores sociodemográficos e comportamentais e a ocorrência da obesidade entre 2014 e 2021 em adultos da cidade de São Paulo, Brasil. Realizou-se estudo prospectivo com 1.241 adultos paulistanos, com 18 anos ou mais, participantes da coorte Inquérito de Saúde de São Paulo (ISA) - Atividade Física e Ambiente. O desfecho foi obesidade (sim/não), classificada por meio do índice de massa corporal e com pontos de corte específicos para cada faixa etária. As variáveis de exposição foram: sexo, idade, escolaridade, cor da pele, estado marital, coordenadoria regional de saúde, atividade física nos quatro domínios e comportamentos sedentários. Foram utilizados modelos de regressão logística multinível para a análise longitudinal. Houve aumento significativo de 27,7% na prevalência de obesidade (de 22,6% para 28,9%). Pessoas que praticavam ao menos 150 minutos semanais de atividade física no lazer (OR = 0,44; IC95%: 0,26; 0,76), entre 10 e 150 minutos semanais de atividade física de deslocamento (OR = 0,49; IC95: 0,30; 0,80) e sem companheiro(a) (OR = 0,47; IC95%: 0,28; 0,78) tiveram menos chances de ter obesidade. Pessoas entre 40 e 59 anos (OR = 5,00; IC95%: 2,02; 12,38) e de cor de pele preta (OR = 4,70; IC95%: 1,85; 11,95) apresentaram maiores chances de ter obesidade. O estudo identificou um aumento na prevalência de obesidade durante o período, com aumento nas chances para pessoas de meia idade e cor da pele preta, e diminuição nas chances para pessoas que vivem sem companheiro(a) e para praticantes de atividades físicas no lazer e como forma de deslocamento. Esses resultados podem contribuir para dar suporte a programas e políticas para o controle da obesidade.

Resumen OBJETIVO: Identificar los factores sociodemográficos, patológicos, psicosociales y de estilo de vida relacionados con la edad a la que inicia la menopausia. MATERIALES Y MÉTODOS: Estudio secundario de corte transversal de la ronda 2018 del Estudio Nacional de Salud y Envejecimiento en México (ENASEM) que cuenta con 17,114 registros de sujetos de uno y otro sexo provenientes de toda la República Mexicana. Criterios de inclusión: mujeres de 40 años, con información de las variables: edad al inicio de la menopausia, lugar de residencia, estado civil, escolaridad, peso, estatura, tabaquismo, ingesta de alcohol, sedentarismo, depresión, hipertensión arterial, diabetes mellitus, algún tipo de cáncer e histerectomía. Se hizo un análisis comparativo de la edad a la menopausia con cada uno de los factores y un análisis multivariado para determinar los factores asociados. Las mujeres con histerectomía, y un grupo de mujeres con ≤ 6 años en la posmenopausia, se analizaron aparte. RESULTADOS: De 9017 mujeres registradas (con límites de edad de 40 y 90 años), 7132 (81%) conservaban el útero y los ovarios. El promedio de edad a la menopausia, sin ajuste, fue 47.8 ± 4.5 años. La histerectomía la anticipa en 2.3 años y la escolaridad mayor a la secundaria la retrasa 5 meses. La edad ajustada fue 48.0 ± 4.3 años y en el grupo con menopausia reciente 50.0 ± 2.8 años. CONCLUSIÓN: La menopausia natural se inicia entre los 48 y 50 años, la histerectomía la adelanta hasta dos años y la escolaridad de secundaria y superior la retrasa 6 meses por cada incremento de nivel escolar. El hecho de vivir en una zona rural o urbana también influye en el tiempo en que comienza la menopausia natural.

Abstract OBJECTIVE: To identify sociodemographic, pathological, psychosocial, and lifestyle factors associated with age at menopause onset. MATERIALS AND METHODS: Secondary cross-sectional study of the 2018 round of the National Study of Health and Aging in Mexico (ENASEM), with 17,114 records of male and female subjects from all over Mexico. Inclusion criteria: women aged 40 years with information on the following variables: age at onset of menopause, place of residence, marital status, education, weight, height, smoking, alcohol consumption, sedentary lifestyle, depression, hypertension, diabetes mellitus, any type of cancer and hysterectomy. A comparative analysis of age at menopause was made with each of these factors and a multivariate analysis was performed to determine the associated factors. Women with hysterectomy and a group of women ≤ 6 years postmenopausal were analyzed separately. RESULTS: Of 9017 women enrolled (with age limits of 40 and 90 years), 7132 (81%) retained uterus and ovaries. The mean age at menopause without adjustment was 47.8 ± 4.5 years. Hysterectomy brought it forward by 2.3 years and education beyond high school delayed it by 5 months. The adjusted age was 48.0 ± 4.3 years and in the recent menopause group 50.0 ± 2.8 years. CONCLUSION: Natural menopause occurs between 48 and 50 years of age, hysterectomy brings it forward by up to two years, and secondary and higher education delays it by 6 months for each additional year of schooling. Living in a rural or urban area also influences the time of onset of natural menopause.

ABSTRACT Introduction: Systemic arterial hypertension is a chronic disease with high prevalence, and at the same time a disease and a risk factor for other chronic non-communicable diseases, due to its potential to cause hidden damage in target organs. Objective: To determine subclinical morbidity in hypertensive patients treated in a medical consultation of a penitentiary unit of the Ministry of Interior in the province of Camagüey, between 2020 and 2022. Materials and methods: An observational, descriptive and longitudinal study was carried out on the relationship between hidden target organ lesion and blood tension levels, in a sample of 82 hypertensive patients with normal clinical examination. From them, age, skin color, blood pressure figures, personal pathological antecedents, toxic habits, glomerular filtration, electrocardiogram and Mini-Mental State Examination were obtained, which were managed according to descriptive statistics. Results: The age group between 31 and 50 years, white, sedentary, and obese people predominated, also finding a high percent of smokers, with a small number of alcoholic and drug addicts; a high percentage of patients suffered from renal damage according to glomerular filtration. Cardiovascular damage diagnosed by electrocardiographic alterations appeared in a third of the sample, and neurological damage from the Mini-Mental test, was observed in more than half of the sample. Conclusions: All the studied patients presented some type of subclinical organic damage.

RESUMEN Introducción: La hipertensión arterial sistémica es una enfermedad crónica con alta prevalencia, y a la vez una enfermedad y un factor de riesgo para otras enfermedades crónicas no trasmisibles, debido a su potencialidad de ocasionar daño oculto en órganos diana. Objetivo: Determinar la morbilidad subclínica en el paciente hipertenso atendido en un consultorio del Ministerio del Interior de una unidad penitenciaria en la provincia de Camagüey, entre los años 2020 y 2022. Materiales y métodos: Se realizó un estudio observacional, descriptivo, longitudinal sobre la relación existente entre lesión oculta de órgano diana y las cifras de tensión arterial, en una muestra dada por 82 pacientes hipertensos, con examen clínico normal. De estos se obtuvo edad, color de la piel, cifras de tensión arterial, antecedentes patológicos personales, hábitos tóxicos, filtrado glomerular, electrocardiograma y Mini-Mental State Examination, los cuales fueron manejados según estadísticas descriptivas. Resultados: Predominó el grupo de edades entre 31 y 50 años, blancos, sedentarios y obesos, encontrando, además, un elevado por ciento de fumadores, con un reducido número de alcohólicos y drogadictos; un alto por ciento de pacientes sufría de daño renal según filtrado glomerular. El daño cardiovascular diagnosticado por alteraciones electrocardiográficas apareció en un tercio de la muestra, y el daño neurológico por el test Mini-Mental, se observó en más de la mitad. Conclusiones: La totalidad de los pacientes estudiados presentaba algún tipo de daño orgánico subclínico.

Resumo Fundamento O óxido nítrico (NO) desempenha um papel importante na regulação da pressão arterial (PA), atuando diretamente na resistência vascular periférica por meio da vasodilatação. O treinamento físico (via eNOS/NO) e a ingestão de nitrito foram considerados os principais estímulos para o aumento do NO. Objetivo No presente estudo, examinamos os efeitos da administração oral de nitrito e do treinamento com exercícios aeróbicos sobre a PA e rigidez arterial de ratos Wistar. Métodos Trinta e nove (39) ratos Wistar machos jovens foram divididos nos seguintes grupos (n=9 ou 10 por grupo): Sedentário-Controle (SC), Sedentário-Nitrito (SN), Treinado-Controle (TC) e Treinado-Nitrito (TN). Eles foram submetidos a treinamento físico aeróbico em esteiras por 8 semanas (50-60% da capacidade física, 1h/dia, 5 dias/semana) ou mantidos sedentários. Nos últimos 6 dias de treinamento, nitrito foi administrado oralmente (15 mg/Kg por gavagem). A PA, a rigidez arterial e as concentrações plasmáticas e teciduais de nitrito foram avaliadas após o treinamento e o período de administração oral de nitrito. O nível de significância foi definido como p < 0,05. Resultados A administração oral de nitrito foi eficaz na redução dos valores de rigidez arterial (TN, -23%; e SN, -15%). Ambos os grupos que tiveram apenas um tipo de intervenção apresentaram PA sistólica menor em comparação com o controle (TC vs. SC, -14,23; e SN vs. SC, - 12,46). Conclusão Assim, concluímos que a administração oral de curta duração (6 dias), associada a um programa de treinamento físico aeróbico promovem diversos benefícios hemodinâmicos em ratos Wistar machos, como melhorias na rigidez arterial e na PA. Essas respostas sugerem que o treinamento físico e a suplementação de nitrito de sódio podem ser alternativas satisfatórias para a prevenção e tratamento da hipertensão. NO (NO , (PA) vasodilatação via eNOS/NO eNOSNO eNOS estudo 39 (39 n=9 n9 n 9 (n= 1 grupo grupo) SedentárioControle Sedentário Controle SC (SC) SedentárioNitrito Nitrito (SN) TreinadoControle Treinado TC TreinadoNitrito TN. TN . (TN) 5060% 5060 50 60% 60 (50-60 física 1hdia hdia 1h dia h 1h/dia dias/semana diassemana semana sedentários 15 (1 mgKg mg Kg gavagem. gavagem gavagem) 005 0 05 0,05 TN, (TN 23% 23 -23% 15%. 15% -15%) vs 14,23 1423 14 -14,23 12,46. 1246 12,46 12 46 12,46) Assim ( dias, dias) hipertensão (PA 3 (3 n= (n (SC (SN 506 (50-6 00 0,0 2 -23 -15% 14,2 142 -14,2 124 12,4 4 (50- 0, -2 -15 14, -14, 12, (50 -1 -14 (5

Abstract Background Nitric Oxide (NO) plays an important role in blood pressure (BP) regulation, acting directly on peripheral vascular resistance through vasodilation. Physical training (via eNOS/NO) and intake of nitrite have been considered major stimuli to increase NO. Objective We examined the effects of oral nitrite administration and aerobic exercise training on BP and arterial stiffness in Wistar rats. Methods Thirty-nine (39) young male Wistar rats were divided into the following groups (n = 9 or 10 per group): Sedentary-Control (SC), Sedentary-Nitrite (SN), Trained-Control (TC), and Trained-Nitrite (TN). They were submitted to aerobic physical training on treadmills for 8 weeks (50-60% of physical capacity, 1h/day, 5 days/week) or kept sedentary. In the last 6 days of training, oral nitrite was administered (15 mg/Kg by gavage). BP, arterial stiffness, and plasma and tissue nitrite concentrations were assessed after the training and oral nitrite administration period. The significant level was defined as p < 0.05. Results Oral administration of nitrite was effective in reducing arterial stiffness values (TN, -23%; and SN, -15%). Both groups that had only one type of intervention showed lower systolic BP compared with control (TC vs. SC, -14.23; and SN vs. SC, - 12.46). Conclusion We conclude that short-term oral administration for 6 days and an aerobic physical training program promote several hemodynamic benefits in male Wistar rats, such as improvements in arterial stiffness and BP. These responses suggest that physical training and sodium nitrite supplementation can be alternatives for the prevention and treatment of hypertension. NO (NO (BP regulation vasodilation via eNOS/NO eNOSNO eNOS Thirtynine Thirty nine 39 (39 n 1 group group) SedentaryControl Sedentary Control SC , (SC) SedentaryNitrite Nitrite (SN) TrainedControl Trained TC, TC (TC) TrainedNitrite TN. TN . (TN) 5060% 5060 50 60% 60 (50-60 capacity 1hday hday 1h day h 1h/day days/week daysweek week sedentary 15 (1 mgKg mg Kg gavage. gavage gavage) period 005 0 05 0.05 TN, (TN 23% 23 -23% 15%. 15% -15%) vs 14.23 1423 14 -14.23 12.46. 1246 12.46 12 46 12.46) shortterm short term hypertension 3 (3 (SC (SN 506 (50-6 ( 00 0.0 2 -23 -15% 14.2 142 -14.2 124 12.4 4 (50- 0. -2 -15 14. -14. 12. (50 -1 -14 (5

Resumo Fundamento A obesidade está associada ao desenvolvimento de doenças cardiovasculares e constitui um grave problema de saúde pública. Em modelos animais, a alimentação com uma dieta hiperlipídica (DH) compromete a estrutura e a função cardíaca e promove estresse oxidativo e apoptose. O treinamento resistido (TR), entretanto, tem sido recomendado como coadjuvante no tratamento de doenças cardiometabólicas, incluindo a obesidade, porque aumenta o gasto energético e estimula a lipólise. Objetivo Na presente revisão sistemática, nosso objetivo foi avaliar os benefícios do TR no coração de ratos e camundongos alimentados com DH. Métodos Foram identificados estudos originais por meio de busca nas bases de dados PubMed, Scopus e Embase de dezembro de 2007 a dezembro de 2022. O presente estudo foi conduzido de acordo com os critérios estabelecidos pelo PRISMA e registrado no PROSPERO (CRD42022369217). O risco de viés e a qualidade metodológica foram avaliados pelo SYRCLE e CAMARADES, respectivamente. Os estudos elegíveis incluíram artigos originais publicados em inglês que avaliaram desfechos cardíacos em roedores submetidos a mais de 4 semanas de TR e controlados por um grupo controle sedentário alimentado com DH (n = 5). Resultados Os resultados mostraram que o TR atenua o estresse oxidativo cardíaco, a inflamação e o estresse do retículo endoplasmático. Também modifica a atividade de marcadores de remodelamento estrutural, apesar de não alterar parâmetros biométricos, parâmetros histomorfométricos ou a função contrátil dos cardiomiócitos. Conclusão Nossos resultados indicam que o TR parcialmente neutraliza o remodelamento cardíaco adverso induzido pela DH, aumentando a atividade dos marcadores de remodelamento estrutural; elevando a biogênese mitocondrial; reduzindo o estresse oxidativo, marcadores inflamatórios e estresse do retículo endoplasmático; e melhorando os parâmetros hemodinâmicos, antropométricos e metabólicos. pública animais (DH apoptose TR, , (TR) entretanto cardiometabólicas lipólise sistemática PubMed 200 2022 CRD42022369217. CRD42022369217 CRD . (CRD42022369217) CAMARADES respectivamente n 5. 5 5) endoplasmático estrutural biométricos cardiomiócitos mitocondrial hemodinâmicos metabólicos (TR 20 202 CRD4202236921 (CRD42022369217 2 CRD420223692 (CRD4202236921 CRD42022369 (CRD420223692 CRD4202236 (CRD42022369 CRD420223 (CRD4202236 CRD42022 (CRD420223 CRD4202 (CRD42022 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

Abstract Background Obesity is associated with the development of cardiovascular diseases and is a serious public health problem. In animal models, high-fat diet (HFD) feeding impairs cardiac structure and function and promotes oxidative stress and apoptosis. Resistance exercise training (RT), however, has been recommended as coadjutant in the treatment of cardiometabolic diseases, including obesity, because it increases energy expenditure and stimulates lipolysis. Objective In this systematic review, we aimed to assess the benefits of RT on the heart of rats and mice fed HFD. Methods Original studies were identified by searching PubMed, Scopus, and Embase databases from December 2007 to December 2022. This study was conducted in accordance with the criteria established by PRISMA and registered in PROSPERO (CRD42022369217). The risk of bias and methodological quality was evaluated by SYRCLE and CAMARADES, respectively. Eligible studies included original articles published in English that evaluated cardiac outcomes in rodents submitted to over 4 weeks of RT and controlled by a sedentary, HFD-fed control group (n = 5). Results The results showed that RT mitigates cardiac oxidative stress, inflammation, and endoplasmic reticulum stress. It also modifies the activity of structural remodeling markers, although it does not alter biometric parameters, histomorphometric parameters, or the contractile function of cardiomyocytes. Conclusion Our results indicate that RT partially counteracts the HFD-induced adverse cardiac remodeling by increasing the activity of structural remodeling markers; elevating mitochondrial biogenesis; reducing oxidative stress, inflammatory markers, and endoplasmic reticulum stress; and improving hemodynamic, anthropometric, and metabolic parameters. problem models highfat high fat HFD (HFD apoptosis RT, , (RT) however obesity lipolysis review PubMed Scopus 200 2022 CRD42022369217. CRD42022369217 CRD . (CRD42022369217) CAMARADES respectively sedentary HFDfed n 5. 5 5) inflammation markers parameters cardiomyocytes HFDinduced induced biogenesis hemodynamic anthropometric (RT 20 202 CRD4202236921 (CRD42022369217 2 CRD420223692 (CRD4202236921 CRD42022369 (CRD420223692 CRD4202236 (CRD42022369 CRD420223 (CRD4202236 CRD42022 (CRD420223 CRD4202 (CRD42022 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

Resumo: O objetivo foi analisar o efeito de diferentes estratégias de intervenção nas aulas de educação física sobre a redução do tempo em comportamento sedentário. Trata-se de uma intervenção randomizada, de base escolar e característica fatorial, realizada com estudantes de 1º ano do ensino médio de 11 escolas de tempo integral, em três situações de intervenção: (A) escolas com duas aulas extras de educação física por semana; (B) escolas com ações de treinamento e engajamento para professores de educação física; (C) escolas com a união das estratégias A e B; e (D) um grupo de escolas controle. Acelerometria foi utilizada para obter a medida de efeito do desfecho principal (comportamento sedentário). Regressão linear foi utilizada tanto para a análise da variação do tempo em comportamento sedentário entre o baseline e pós-intervenção como para a análise de potenciais fatores mediadores da relação entre exposição e desfecho. Participaram do estudo 1.295 estudantes. A intervenção B foi capaz de reduzir significativamente o tempo em comportamento sedentário de meninos (61,5 minutos, p < 0,01) e meninas (34,8 minutos, p = 0,04) em comparação ao grupo controle, demonstrando respectivamente tamanhos de efeitos médio (0,61) e pequeno (0,32). A redução do tempo em comportamento sedentário entre os estudantes do grupo B foi significativamente mediada pela redução da amotivação (AMO) (meninos c: -0,402; e meninas c: -0,376). A oferta de formação continuada para professores de educação física se mostrou estratégia fundamental para reduzir o tempo em comportamento sedentário dos adolescentes, sendo essa redução mediada pela diminuição da AMO para as aulas de educação física.

Abstract: This study aimed to analyze the effect of different intervention strategies in physical education classes on the reduction of sedentary time. This is a randomized, school-based intervention with factorial characteristics, carried out with freshmen high school students from 11 full-time schools, allocated in three intervention situations: (A) schools with two extra physical education classes per week; (B) schools with training and engagement actions for physical education teachers; (C) Schools with both A and B strategies; and (D) a group of control schools. Accelerometry was used to obtain the effect measure of the main outcome (sedentary behavior). Linear regression was used to analyze the time variation in sedentary behavior between baseline and post-intervention, as well as to analyze potential mediating factors of the relation between exposure and outcome. A total of 1,295 students participated in the study. Intervention B significantly reduced the time in sedentary behavior of boys (61.5 minutes, p < 0.01) and girls (34.8 minutes, p = 0.04) when compared to the control group, showing respectively medium (0.61) and small (0.32) effect size. The reduction in time in sedentary behavior among students in group B was significantly mediated by reduced lack of motivation (AMO) (boys c: -0.402, and girls c: -0.376). The offer of continuing training for physical education teachers proved to be a fundamental strategy to reduce the sedentary time of adolescents, which was mediated by the AMO reduction for physical education classes.

Resumen: El objetivo fue analizar el efecto de diferentes estrategias de intervención en las clases de educación física en la reducción del tiempo de comportamiento sedentario. Se trata de una intervención escolar, aleatorizada y con características factoriales, realizada con alumnos de 1.º de secundaria de 11 colegios de jornada completa, asignados a 3 situaciones de intervención: (A) escuelas con dos clases extras de educación física por semana; (B) escuelas con acciones de formación y compromiso para profesores de educación física; (C) escuelas con la combinación de las estrategias A y B; y (D) un grupo de escuelas de control. Se utilizó acelerometría para obtener la medida del efecto del desenlace principal (comportamiento sedentario). Se utilizó la regresión lineal tanto para analizar la variación en el tiempo en el comportamiento sedentario entre el inicio y la posintervención, como para analizar los posibles factores mediadores de la relación entre la exposición y el desenlace. Participaron en el estudio 1.295 estudiantes. La intervención B logró reducir significativamente el tiempo dedicado a comportamiento sedentario en niños (61,5 minutos, p < 0,01) y niñas (34,8 minutos, p = 0,04) en comparación con el grupo control, lo que demuestra respectivamente tamaños de efecto mediano (0,61) y pequeño (0,32). La reducción del tiempo de comportamiento sedentario entre los estudiantes del grupo B fue significativamente mediana por la reducción de la desmotivación (AMO) (niños c: -0,402 y niñas c: -0 376). La oferta de formación continua para profesores de educación física resultó ser una estrategia fundamental para reducir el tiempo de conducta sedentaria entre los adolescentes, y esta reducción mediada por la disminución de la AMO para las clases de educación física.

Abstract Background Recently, a new heart failure (HF) classification was made considering the left ventricular ejection fraction (LVEF) phenotype. Comprehensive assessments of the groups are required to guide patient management. Objective To determine the differences in sociodemographic, clinical, functional aerobic capacity, and health-related quality of life (HRQOL) variables in patients with HF classified with different LVEFs and to explore the correlations between the variables. Methods This work is a cross-sectional descriptive and correlational study. Three groups of patients with HF (LVEF≥50%, LVEF<40%, and LVEF40-49%) were compared. Sociodemographic, clinical variables and functional aerobic capacity with Sit to Stand (STS), 6-minute walk test (6MWT), Duke Activity Status Index (DASI), Minnesota Living with HF Questionnaire (MLFHQ), and Patient Health Questionnaire 9 (PHQ-9) were considered. The Chi-square test, one-way analysis of variance (ANOVA) test, and Spearman's correlation were used for statistical analysis. The statistical significance level was set at 5%. Results A total of 209 patients were admitted with a diagnosis of HF, with a more significant number of men. Marital status was a predominantly stable union in the HF with preserved ejection fraction (HFpEF) and HF with mid-range ejection fraction (HFmrEF) groups. A sedentary lifestyle was lower in the HF with reduced ejection fraction (HFrEF) group 59 (84.3%), p-value = 0.033, and the angina pectoris was higher in the HFpEF 30 (42.9%). Systolic blood pressure at the end of the 6MWT evidenced a higher score in HFpEF 132.0±17.25 concerning HFrEF 128.0±16.57, p-value=0.043. The fat percentage was higher in HFpEF 30.20±8.80 regarding the HFmrEF group 26.51±7.60, p-value = 0.028. Conclusion There were significant differences according to the LVEF classification in marital status, angina symptoms, fat percentage, and blood pressure at rest. Recently (HF (LVEF phenotype management sociodemographic healthrelated health related HRQOL (HRQOL crosssectional cross sectional study LVEF≥50%, LVEF50 50 (LVEF≥50% LVEF40 40 LVEF<40% LVEF4049% LVEF4049 49% 49 LVEF40-49% compared Sociodemographic STS, STS , (STS) 6minute minute 6 6MWT, MWT (6MWT) DASI, DASI (DASI) MLFHQ, MLFHQ (MLFHQ) PHQ9 PHQ (PHQ-9 considered Chisquare Chi square oneway one way ANOVA (ANOVA Spearmans Spearman s 5 5% 20 men (HFpEF midrange mid range (HFmrEF (HFrEF 84.3%, 843 84.3% 84 3 (84.3%) pvalue p value 0033 0 033 0.033 42.9%. 429 42.9% . 42 (42.9%) 13201725 132 17 25 132.0±17.2 12801657 128 16 57 128.0±16.57 pvalue=0.043. pvalue0043 value=0.043. 043 p-value=0.043 3020880 8 80 30.20±8.8 2651760 26 51 7 60 26.51±7.60 0028 028 0.028 symptoms rest LVEF≥50% LVEF5 (LVEF≥50 LVEF4 4 LVEF<40 LVEF404 LVEF40-49 (STS (6MWT (DASI (MLFHQ (PHQ- 2 84.3 (84.3% 003 03 0.03 42.9 (42.9% 1320172 13 1 132.0±17. 1280165 12 128.0±16.5 pvalue=0.043 pvalue004 value0043 value=0.043 04 p-value=0.04 302088 30.20±8. 265176 26.51±7.6 002 02 0.02 LVEF≥50 (LVEF≥5 LVEF<4 LVEF40-4 (PHQ 84. (84.3 00 0.0 42. (42.9 132017 132.0±17 128016 128.0±16. pvalue=0.04 pvalue00 value004 value=0.04 p-value=0.0 30208 30.20±8 26517 26.51±7. LVEF≥5 (LVEF≥ LVEF< LVEF40- (84. 0. (42. 13201 132.0±1 12801 128.0±16 pvalue=0.0 pvalue0 value00 value=0.0 p-value=0. 3020 30.20± 2651 26.51±7 LVEF≥ (84 (42 1320 132.0± 1280 128.0±1 pvalue=0. value0 value=0. p-value=0 302 30.20 265 26.51± (8 (4 132.0 128.0± pvalue=0 value=0 p-value= 30.2 26.51 ( 132. 128.0 pvalue= value= 30. 26.5 128. 26.

Resumo O objetivo do estudo foi analisar a relação entre tempo gasto em comportamentos sedentários, dieta e excesso de peso em adolescentes. Estudo transversal com dados do Estudo Longitudinal sobre Comportamento Sedentário, Atividade Física, Hábitos Alimentares e Saúde do Adolescente - Estudo LONCAAFS. Participaram 1.438 adolescentes (10 a 14 anos) de escolas públicas de João Pessoa, Brasil. Para avaliar os efeitos combinados do tempo excessivo no comportamento sedentário e no consumo de dois grupos de alimentos: Conveniência e Prudente sobre o excesso de peso, foram realizadas análises de regressão logística múltipla, ajustadas para energia, nível de atividade física, sexo e idade. O tempo excessivo em comportamento sedentário aumentou em 37% a chance de os adolescentes apresentarem excesso de peso (OR = 1,37; IC95%: 1,04-1,80). Essa chance aumentou para 43% quando os adolescentes apresentaram, simultaneamente, comportamento sedentário excessivo e alto consumo do grupo de alimentos de conveniência (OR = 1,43; IC95%: 1,05-1,94), e aumentou para 39% naqueles com excesso de comportamento sedentário e baixo consumo de alimentos do Prudente (OR = 1,39; IC95%: 1,04-1,84). O comportamento sedentário excessivo está associado ao excesso de peso e a chance aumenta com o consumo de alimentos convenientes. sedentários Sedentário Física LONCAAFS 1438 1 438 1.43 10 (1 anos Pessoa Brasil múltipla energia física idade 37 OR 1,37 137 IC95% IC95 IC 1,041,80. 104180 1,04 1,80 . 04 80 1,04-1,80) 43 apresentaram simultaneamente 1,43 143 1,051,94, 105194 1,05 1,94 , 05 94 1,05-1,94) 39 1,39 139 1,041,84. 104184 1,84 84 1,04-1,84) convenientes 1.4 ( 3 1,3 13 IC9 041 1,041,80 10418 104 1,0 180 1,8 0 8 1,04-1,80 4 1,4 051 1,051,94 10519 105 194 1,9 9 1,05-1,94 1,041,84 184 1,04-1,84 1. 1, 1,041,8 1041 18 1,04-1,8 1,051,9 1051 19 1,05-1,9 1,041, 1,04-1, 1,051, 1,05-1, 1,041 1,04-1 1,051 1,05-1 1,04- 1,05-

Abstract The aim of the present study was to analyze the relationship between time spent engaged in sedentary behaviors, type of diet, and overweight in adolescents. A cross-sectional study using data from the Longitudinal Study on Sedentary Behavior, Physical Activity, Eating Habits, and Health of Adolescents - LONCAAFS Study. A total of 1,438 adolescents (10 to 14 years old) from public schools in the city of João Pessoa, Brazil, participated in the study. To evaluate the combined effects of excessive time in sedentary behavior and consumption from two food groups: Convenience and Prudent on overweight, we performed multiple logistic regression analyses, adjusted for energy, level of physical activity, sex, and age. Excessive time in sedentary behavior increased the chance of adolescents being overweight by 37% (OR = 1.37; 95%CI: 1.04-1.80). This chance increased to 43% when the adolescents were simultaneously engaged in excessive sedentary behavior and had high consumption of the Convenience food group (OR = 1.43; 95%CI: 1.05-1.94) and increased to 39% on those who engaged in excessive sedentary behavior and had low consumption of foods from the Prudent (OR = 1.39; 95%CI: 1.04-1.84). Excessive sedentary behavior is associated with being overweight and the chance increases with the consumption of convenient foods. behaviors diet crosssectional cross sectional Behavior Activity Habits 1438 1 438 1,43 10 (1 old Pessoa Brazil groups analyses energy activity sex age 37 OR 1.37 137 95%CI 95CI CI 95 1.041.80. 104180 1.04 1.80 . 04 80 1.04-1.80) 43 1.43 143 1.051.94 105194 1.05 1.94 05 94 1.05-1.94 39 1.39 139 1.041.84. 104184 1.84 84 1.04-1.84) 1,4 ( 3 1.3 13 9 041 1.041.80 10418 104 1.0 180 1.8 0 8 1.04-1.80 4 1.4 051 1.051.9 10519 105 194 1.9 1.05-1.9 1.041.84 184 1.04-1.84 1, 1. 1.041.8 1041 18 1.04-1.8 1.051. 1051 19 1.05-1. 1.041. 1.04-1. 1.051 1.05-1 1.041 1.04-1 1.05- 1.04-

Abstract Background The clinical findings of patients with Chronic Kidney Disease (CKD), which is characterized by malnutrition, sedentary lifestyle, uremia, and catabolism associated with dialysis produce changes in Body Composition (BC), causing increased Fat Mass (FM), decreased in both Lean Mass (LM) and Body Mineral Density (BMD), even despite uremic reversal after a Kidney Transplant (KT); immunosuppressive medications alter BC, increasing the risk of loss of the kidney transplant and cardiovascular diseases. Objective To demonstrate whether there are differences in BC between a group of patients with KT and a group of patients on Hemodialysis (HD), when comparing them with a control group without the disease. Materials and methods In the present observational study, with a comparative design; 125 patients were evaluated (46 with KT, 47 on HD, and 32 from the healthy control group). The BC was evaluated with the full-body Dual-Energy X-Ray Absorptiometry (DEXA) method. Results The mean age and standard deviation (X±SD) of the study subjects were: 28.89 ± 5.76, 27.39 ± 5.04, and 29.63 ± 6.34 years for the HD, KT, and control subjects, respectively. The HD patients presented a total FM of 14.98 ± 6.96 kg in comparison with 20.1 ± 6.5 kg for the control group (p = 0.007), and 19.06 ± 7.94 kg for the group with KT (p = 0.02). The total LM was lower in the KT patients in comparison with the control group (p = 0.023). The content and total BMD were lower in both groups of patients with KT and HD. Conclusions Although a comprehensive improvement in BC was expected after kidney transplantation, the results are not close to “normal’ values, when compared with those of healthy subjects of the same age. CKD, CKD , (CKD) malnutrition lifestyle uremia (BC) FM, (FM) (LM BMD, (BMD) (KT) diseases (HD) disease design 12 46 (4 4 3 group. . group) fullbody full body DualEnergy Dual Energy XRay X Ray DEXA (DEXA method X±SD XSD SD (X±SD 2889 28 89 28.8 576 5 76 5.76 2739 27 39 27.3 504 04 5.04 2963 29 63 29.6 634 6 34 6.3 respectively 1498 14 98 14.9 696 96 6.9 201 20 1 20. 65 6. p 0.007, 0007 0.007 0 007 0.007) 1906 19 06 19.0 794 7 94 7.9 0.02. 002 0.02 02 0.02) 0.023. 0023 0.023 023 0.023) transplantation normal “normal values (CKD (BC (FM (BMD (KT (HD ( 288 2 8 28. 57 5.7 273 27. 50 5.0 296 29. 149 9 14. 69 000 0.00 00 190 19. 79 7. 0.0 5. 0.