This review provides an overview of the recent progress in organic electrosynthesis in Brazil, ranging from 2013 to 2023. By highlighting the principles, applications, and limitations of various electrosynthetic methodologies, this article aims to contribute to the understanding of basic principles and stimulate research in this field in Brazil. Moreover, the limitations and challenges associated with organic electrosynthesis are covered. Factors such as electrode material selection, solvent effects, and reaction optimization are discussed, highlighting the need for further research and development to overcome these obstacles. Finally, future prospects are outlined. Brazil 201 2023 applications methodologies Moreover covered selection effects discussed obstacles Finally outlined 20 202 2

In the present article, the scientific journey that led to the development of the Nernst equation, a cornerstone in modern electrochemistry, is discussed. The paper not only explores historical achievements but also traces the evolution of scientific ideas and highlights the key figures who laid the conceptual and experimental groundwork for the seminal contributions of Nernst to the understanding of electrochemical systems. In this exploration, particular attention is paid to the examination of the first three articles published by Nernst between 1888 and 1889. These essential works marked the inception of the engagement of Nernst with the Leipzig Physical Chemistry circle, comprising the distinguished quartet: van’t Hoff, Arrhenius, Ostwald, and Nernst himself. Furthermore, the present study examines the intricate relationship between the Nernst equation and the four basic laws of Thermodynamics, all in an approach accessible to undergraduate students. A concise review elucidates the interpretation and significance of these foundational thermodynamic principles and explain how they hold the formulation of the Nernst equation. article electrochemistry discussed systems exploration 188 1889 circle quartet vant van t Hoff Arrhenius Ostwald himself Furthermore Thermodynamics students 18 1

Layered double hydroxides (LDHs) and related materials have been studied for a long time and their application in catalytic processes remain attractive due to the tuned properties, morphologies and metal-support interactions obtained from a variety of composition and synthesis route. In this mini-review, some important reactions, such as photocatalysis, electrocatalysis, reduction, carbon-carbon cross-couplings and water-gas shift will be emphasized along with the role of LDHs as catalysts, co-catalysts or catalytic precursors when it was clearly indicated. (LDHs properties metalsupport metal support route minireview, minireview mini review, review mini-review reactions photocatalysis electrocatalysis reduction carboncarbon carbon crosscouplings cross couplings watergas water gas catalysts cocatalysts co indicated

RESUMO: Dentre as neoplasias hematopoiéticas, as leucemias são originadas pelas células mieloides ou linfoides na medula óssea, podendo ser de forma aguda, com um pior prognóstico, principalmente, acometendo gatos com leucemia felina (FeLV positivos) ou, de forma crônica, que apresentam um prognostico reservado, especialmente em gatos idosos. As leucemias possuem várias classificações, cujas diferenciações irão depender de exames complementares como hemograma, mielograma, citologia e citometria de fluxo, importantes para a caracterização e para o melhor tratamento do animal. RESUMO hematopoiéticas óssea aguda prognóstico principalmente FeLV positivos crônica reservado idosos classificações hemograma mielograma fluxo animal

ABSTRACT: Among the hematopoietic neoplasms, leukemias are caused by myeloid or lymphoid cells in the bone marrow, which can either be acute with an unfavorable prognosis and mostly affect cats that tested positive for feline viral leukemia (FeLV) or chronic in older cats that have a poor prognosis. Leukemias have several classifications in which the differentiation depends on complementary tests, such as blood profile, myelogram, cytology. and flow cytometry, which help determine the best treatment for the animal. ABSTRACT neoplasms marrow FeLV (FeLV tests profile myelogram cytology cytometry animal

Over the last two decades, metabolomics has emerged as a pivotal tool in multidisciplinary research, providing invaluable insights into metabolome modulations and finding applications across various scientific domains, including medicine and agronomy. Nonetheless, the absence of standardized procedures in sample preparation, data acquisition, and documentation of data quality presents a significant challenge. This review underscores the critical importance of quality assurance and quality control (QA/QC) in untargeted metabolomics, advocating for the establishment of agreed-upon QA/QC reporting standards within the scientific community. We discuss the requisite quality controls at various stages of untargeted metabolomics studies, encompassing blank samples, pooled samples, and the utilization of external quality control samples. Methods for assessing accuracy, reproducibility, and identifying/correcting batch effects are addressed. Furthermore, emphasis is placed on standardizing the description of QA/QC data in scientific publications and repositories to foster reproducibility and transparency. We recommend the publication of QC data alongside studies in appropriate databases to facilitate data comparison and sharing among researchers, thereby enhancing the quality of untargeted metabolomics research. In summary, implementing standardized QA/QC data reporting, along with promoting best practices within the untargeted metabolomics community, is crucial for improving result quality and credibility and advancing research utilizing this powerful technique. decades domains agronomy Nonetheless preparation acquisition challenge QAQC QA (QA/QC agreedupon agreed upon community samples accuracy identifyingcorrecting identifying correcting addressed Furthermore transparency researchers summary technique

The history of the discovery, use, and development of dyes is closely linked to the history of humanity itself. Among the first records of human civilization are cave paintings made from, e.g., fruits, plants, minerals, and insects. Over the centuries, using different techniques, colors have been given to all types of materials and products, from clothing to food. The chemicals responsible for colors are dyes - a vast collection of molecules of the most varied compositions, but which have in common the absorption of light within the visible window of the electromagnetic spectrum. This article aims not only to review the properties of some classes of natural dyes, their origins, and their applications but also to describe the various computational chemistry methods involved in designing new bio-inspired molecules. discovery use itself eg e g e.g. fruits plants minerals insects centuries techniques products food compositions spectrum origins bioinspired bio inspired e.g

RESUMO O consumo de dióxido de carbono atmosférico pelo intemperismo tampona o efeito estufa na Terra em escala de tempo geológica. Esse mecanismo é chamado de sumidouro de carbono de silicato (SCS). Saprolito representa parte da frente de intemperismo do manto terrestre, mas historicamente não recebeu muita atenção dos geocientistas. Em escala global, o Brasil é o maior contribuinte para o SCS e o quarto maior contribuinte em número de publicações sobre saprolito. Neste estudo, a produção científica brasileira sobre o assunto de 1990 a 2022 foi avaliada, considerando publicações indexadas nas bases de dados Web of Science, SciELO e Scopus. Foram recuperados cento e oitenta artigos científicos. Na última década, sete artigos foram publicados por ano. Ao longo dos 32 anos considerados, o número de artigos sobre saprolito aumentou. A maioria dos estudos foi concentrada na região sudeste do Brasil, onde o estado de Minas Gerais liderou em termos de número de publicações (28,49%). As principais áreas em que os artigos foram publicados estavam relacionadas à ecologia, Terra e marinha; no entanto, foram citados por várias outras, incluindo as áreas de saúde e política. Uma comparação do número de publicações por bacia e o tamanho do SCS mostrou que havia menos estudos da Bacia Amazônica do que da Bacia do Paraná. Em conclusão, a fronteira geográfica para o estudo do saprolito no território brasileiro é a Bacia do Rio Amazonas, e a fronteira metodológica está relacionada à dinâmica de fluídos/gases e ao papel dos micróbios no intemperismo em profundidade. geológica SCS. . (SCS) terrestre geocientistas global 199 202 avaliada Science Scopus científicos década ano 3 considerados aumentou 28,49%. 2849 28,49% 28 49 (28,49%) ecologia marinha entanto outras política Paraná conclusão Amazonas fluídosgases fluídos gases profundidade (SCS 19 20 284 28,49 2 4 (28,49% 1 28,4 (28,49 28, (28,4 (28, (28 (2 (

ABSTRACT The consumption of atmospheric carbon dioxide by weathering buffers the greenhouse effect on Earth on a geological timescale. This mechanism is called the silicate carbon sink (SCS). Saprolite represents part of the weathering front of the Earth’s mantle, but historically, it has not received much attention from geoscientists. On a global scale, Brazil is the largest contributor to the SCS and the fourth largest contributor to the number of saprolite publications. In this study, Brazilian scientific production on the subject from 1990 to 2022 was assessed, considering publications indexed in the Web of Science, SciELO and Scopus databases. One hundred-eighty scientific articles were retrieved. In the last decade, seven articles were published per year. Over the 32 years under consideration, the number of articles on saprolite has increased. Most of the studies were concentrated in the southeastern region of Brazil, where the state of Minas Gerais led in terms of the number of publications (28.49%). The main areas in which the articles were published were related to ecology, Earth, and marine; however, they were cited by several others, including the areas of health and politics. A comparison of the number of publications per basin and the size of the SCS showed that there were fewer studies from the Amazon Basin than from the Paraná Basin. In conclusion, the geographical frontier for the study of saprolite in the Brazilian territory is the Amazon River Basin, and the methodological frontier is related to fluid/gas dynamics and the role of microbes in weathering at depth. timescale SCS. . (SCS) Earths s mantle historically geoscientists scale 199 202 assessed Science databases hundredeighty hundred eighty retrieved decade year 3 consideration increased 28.49%. 2849 28.49% 28 49 (28.49%) ecology marine however others politics conclusion fluidgas fluid gas depth (SCS 19 20 284 28.49 2 4 (28.49% 1 28.4 (28.49 28. (28.4 (28. (28 (2 (

ABSTRACT Purpose: This study aimed to evaluate the morphometric and volumetric dimensions of the lacrimal gland in patients with inactive thyroid eye disease and compare them with the values reported in the literature. Methods: This case series evaluated consecutive patients with inactive thyroid eye disease treated at a tertiary eye hospital from 2015 to 2020. The patients’ baseline demographics and clinical characteristics were obtained. The axial and coronal length, width, and volume of the lacrimal gland were measured on computed tomography scan images, and the results were statistically analyzed. Results: A total of 21 patients (42 orbits) with inactive thyroid eye disease were evaluated. Their mean age was 49.0 ± 14.6 years, and 12 (57.1%) of them were men. The main complaint was dryness, and the majority of the patients had good vision and mild proptosis. The mean axial length and width of the lacrimal gland were 19.3 ± 3.9 mm and 7.5 ± 2.1 mm, respectively; coronal length and width, 20.4 ± 4.5 mm and 7.5 ± 2.1 mm, respectively; and lacrimal gland volume, 0.825 ± 0.326 mm3. Age, sex, or laterality were not found to be determinants of lacrimal gland enlargement. Conclusion: Patients with thyroid eye disease have enlarged lacrimal gland even in the nonactive phase of the disease multifactorial aspects influence the lacrimal gland in thyroid eye disease, making it difficult to establish a clear correlation with predisposing factors. Further studies are warranted to better understand the association between thyroid eye disease and the lacrimal gland. Purpose literature Methods 201 2020 obtained images analyzed Results 2 42 (4 orbits 490 49 0 49. 146 14 6 14. years 1 57.1% 571 57 (57.1% men dryness proptosis 193 19 3 19. 39 9 3. 75 7 5 7. 2. respectively 204 20 4 20. 45 4. 0825 825 0.82 0326 326 0.32 mm3 Age sex enlargement Conclusion factors 202 ( 57.1 (57.1 082 82 0.8 032 32 0.3 57. (57. 08 8 0. 03 (57 (5

RESUMO A produção de grãos apresenta crescimento constante, entretanto, a capacidade estatística de armazenamento permanece deficitária no Brasil. A falta de estruturas e a precariedade e inadequação no armazenamento ocasionam perdas na pós-colheita, devido ação de fatores que interagem com os grãos, culminando na sua deterioração. Para reversão desses efeitos, o tratamento químico é realizado, contudo, busca-se por sua substituição por substâncias naturais devido a implicações ambientais e medicinais. Objetivou-se com esta revisão, a discussão de uma potencial estratégia sustentável para o tratamento de grãos armazenados, com foco no uso de compostos naturais com propriedades bioativas como antifúngica, antioxidante e inseticida, que os torna potenciais para serem estudados. Foram delineados compostos naturais que possuem propriedades úteis para aplicação no armazenamento de grãos. Pesquisas a respeito do emprego dos compostos naturais no tratamento de grãos são incipientes, carecendo de avanços na identificação de novos compostos promissores, melhor compreensão dos mecanismos de ação e otimização/desenvolvimento de processos de extração, aplicação e formulação eficazes que viabilizem o futuro uso das substâncias. constante entretanto Brasil póscolheita, póscolheita pós colheita, colheita pós-colheita deterioração efeitos realizado contudo buscase busca se medicinais Objetivouse Objetivou revisão armazenados antifúngica inseticida estudados incipientes promissores otimizaçãodesenvolvimento otimização desenvolvimento extração

ABSTRACT Grain production is steadily increasing; however, the static storage capacity remains inadequate in Brazil. The lack of proper facilities and the precarious and inadequate storage conditions lead to post-harvest losses due to factors interacting with the grains, causing their deterioration. Chemical treatments are commonly used to reverse these effects; however, their replacement with natural substances has been sought due to environmental and human health concerns. The objective of this review was to discuss a sustainable strategy for treating stored grains, focusing on the use of natural compounds with bioactive properties, such as antifungal, antioxidant, and insecticidal activities, with potential for further studies. Natural compounds with useful properties for application in grain storage were outlined. Research on the use of natural compounds in grain treatment is still in its early stages, requiring progress in identifying new promising compounds, understanding the mechanisms of action, and developing and optimizing effective extraction, application, and formulation processes to make the use of these substances viable. increasing however Brazil postharvest post harvest grains deterioration effects concerns antifungal antioxidant activities studies outlined stages action extraction viable

RESUMO Objetivo: O objetivo deste estudo foi realizar a correlação genótipo-fenótipo entre os resultados de cariótipos e as alterações neurológicas e psiquiátricas apresentadas em pacientes com síndrome de Turner (ST). Métodos: Um estudo retrospectivo foi conduzido nos registros médicos de 10/140 pacientes com ST e deficiências neuropsicológicas atendidos pelo Serviço de Genética Clínica de um hospital do sul do Brasil. Ademais, uma revisão foi realizada pelas plataformas científicas PubMed e Biblioteca Virtual em Saúde (BVS) de artigos publicados entre 1o de janeiro de 2012 e 1o de janeiro de 2023. Foram selecionados 14 artigos em uma análise em duas etapas. Resultados: Nossa pesquisa mostrou potencial correlação entre alterações neurológicas e psiquiátricas em pacientes com ST. Esses achados corroboram os descritos por outros autores — como a elevada prevalência de dificuldades de aprendizagem ou intelectuais. Entretanto, nossa amostra encontrou mais episódios convulsivos do que os descritos em outros estudos. Conclusões: A correlação estabelecida pode ser devida ao efeito dose-dependente do cromossomo X, visto que nossa revisão sugere que o número de cromossomos sexuais ou o desenvolvimento hormonal está associado a habilidades ou deficiências verbais, sociais e cognitivas. Objetivo genótipofenótipo genótipo fenótipo . (ST) Métodos 10140 10 140 10/14 Brasil Ademais BVS (BVS 201 2023 1 etapas Resultados intelectuais Entretanto estudos Conclusões dosedependente dose dependente X verbais cognitivas (ST 1014 10/1 20 202 101 10/ 2

ABSTRACT Objective: The objective of this study was to establish the genotype-phenotype correlation between karyotype results and the neurological and psychiatric alterations presented in patients with Turner syndrome (TS). Methods: A retrospective study was conducted on the medical records of 10/140 patients with TS and neurophysiological abnormalities seen at a university hospital in southern Brazil. In addition, a literature review spanning the period from January 1, 2012 to January 1, 2023 was carried out using the PubMed and Virtual Health Library databases. Results: Our study showed a potential correlation between neurological and psychiatric alterations in patients with TS. These findings are in accordance with those described in literature such as a high prevalence of learning or intellectual disabilities. However, our sample found more seizure episodes than those reported in other studies. Conclusions: The correlation established could be due to X chromosome dose–effect, as the review suggests that sex chromosome number and hormonal development can be associated with verbal, social, and cognitive skills or impairments. Objective genotypephenotype genotype phenotype . (TS) Methods 10140 10 140 10/14 Brazil addition 1 201 202 databases Results disabilities However studies Conclusions doseeffect dose effect dose–effect verbal social impairments (TS 1014 14 10/1 20 101 10/ 2

This paper elucidates the inseparable connection between the pursuit of a more ecologically sustainable society and the quest for socioeconomic justice. It also demonstrates why Unconditional Basic Income (UBI) is an effective policy to act on both fronts. First, the corresponding theory on environmental and socioeconomic oppression sheds light on the argument that both types of domination stem from the same historical process and are inherently interconnected. Addressing one without considering the other is essentially flawed; they are both features and consequences of present society. Acknowledging the historical debt owed to vulnerable economic classes and developing countries is imperative. Green republicanism could potentially establish a theoretical foundation for social-ecological thinking. Defining freedom as non-domination and applying this concept to nature are essential prerequisites for overcoming socioeconomic and environmental oppression. UBI is presented and discussed theoretically as a strong solution to address these two challenges. It serves not only as a means to facilitate the transition to a post-productivist society, transforming labor relations, but also as a catalyst for the development of circular economies and more sustainable occupations. Additionally, the basic income policy implemented in the city of Maricá, Brazil, is cited as empirical evidence showcasing the environmental and socioeconomic values of UBI. justice (UBI fronts First interconnected flawed imperative socialecological social ecological thinking nondomination non challenges postproductivist post productivist relations occupations Additionally Maricá Brazil

It is well known that during times of social unrest, replacing the constitution is one of the first proposals to emerge, at least in Latin America, as if this constitutional shift could resolve any problem. Constitutional substitution is not a new phenomenon in Latin America; it actually began after the region’s redemocratization. However, it is striking that, despite similar conditions of social unrest, many other countries in the region have not undergone such an encompassing constitutional reform. Our main focus here is to analyze the persistence of constitutions in Latin American countries. We thus ask: What conditions lead democratic countries to keep their constitutions? Using a configurational approach, our preliminary results are promising. Together, four pathways explain why some countries have not replaced their constitutions in democratic contexts, with special emphasis on the number of rights enshrined in these fundamental laws. unrest emerge America problem regions s redemocratization However reform ask approach promising Together contexts laws

RESUMO O trabalho teve como objetivo analisar a influência da atenção e do ceticismo na avaliação do falso discurso mercadológico com apelo ambiental (greenwashing). O suporte teórico da pesquisa assentou-se no estudo do processo da atenção (compreendido em termos de pré-atenção e atenção), assim como da prática de greenwashing e o ceticismo do consumidor. O procedimento metodológico adotou uma abordagem hipotético-dedutiva, realizada por meio de dois experimentos presenciais (n=129 e n=159) com desenho fatorial 2 (atenção/pré-atenção) x 2 (ceticismo presente/ausente), com a mensuração de quatro métricas de interesse (avaliação dos atributos, julgamento acerca da prática de greenwashing, reação emocional ao anúncio e comportamento ambiental de compra), somada ao monitoramento ocular (eyetracker). Foram empregadas a ANOVA one-way para as análises unidimensionais e a ANOVA pelo modelo linear geral (GLM) para as análises multivariadas, com o teste post hoc de Tukey. Como resultado, foi possível observar uma melhor avaliação da prática de greenwashing quando da junção da pré-atenção e da ausência do ceticismo, o que configura um cenário de potencialidade da capacidade de influência desse falso discurso mercadológico no comportamento do consumidor. greenwashing. . (greenwashing) assentouse assentou se compreendido préatenção pré atenção, , atenção) consumidor hipotéticodedutiva, hipotéticodedutiva hipotético dedutiva, dedutiva hipotético-dedutiva n=129 n129 n 129 (n=12 n=159 n159 159 atenção/préatenção atençãopréatenção atenção/pré (atenção/pré-atenção presente/ausente, presenteausente presente/ausente presente ausente presente/ausente) atributos compra, compra compra) eyetracker. eyetracker (eyetracker) oneway one way GLM (GLM multivariadas Tukey resultado (greenwashing n=12 n12 12 (n=1 n=15 n15 15 atençãopré (eyetracker n=1 n1 1 (n= n= (n

ABSTRACT The purpose of this study was to analyze the influence of attention and skepticism in the evaluation of false market discourse with an environmental appeal (greenwashing). The theoretical support for the research was based on the study of the attention process (understood in terms of pre-attention and attention), as well as the practice of greenwashing and consumer skepticism. The methodological procedure adopted a hypothetical-deductive approach, carried out through two face-to-face experiments (n=129 and n=159) with a 2 factorial design (attention/pre-attention) x 2 (present/absent skepticism), with the measurement of four interest metrics (attribute evaluation, judgment about the practice of greenwashing, emotional reaction to the advertisement, and environmental purchase behavior), added to eye tracking. One-way ANOVA was used for one-dimensional analyzes and general linear model (GLM) ANOVA for multivariate analyses, with Tukey's post hoc test. As a result, it was possible to observe a better evaluation of the practice of greenwashing when pre-attentiveness and the absence of skepticism were combined, which sets up a potential scenario for the influence of this false marketing discourse on consumer behavior. greenwashing. . (greenwashing) understood preattention pre attention, , attention) hypotheticaldeductive hypothetical deductive approach facetoface face n=129 n129 n 129 (n=12 n=159 n159 159 attention/preattention attentionpreattention attention/pre (attention/pre-attention present/absent presentabsent present absent skepticism, skepticism) attribute advertisement behavior, behavior behavior) tracking Oneway One way onedimensional one dimensional GLM (GLM analyses Tukeys Tukey s test result preattentiveness attentiveness combined (greenwashing n=12 n12 12 (n=1 n=15 n15 15 attentionpre n=1 n1 1 (n= n= (n

RESUMO Objetivo: Comparar a presença de anticorpos neutralizantes contra o SARS-CoV-2 no leite materno e no sangue das lactantes vacinadas em relação àquelas não vacinadas. Fontes de dados: Foi efetuado registro no International Prospective Register of Systematic Reviews — PROSPERO (CRD42021287554) e foram seguidas as diretrizes do Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Foram elegíveis estudos de coorte, caso-controle e transversais que avaliaram anticorpos contra o SARS-CoV-2 no leite e no sangue de lactantes vacinadas e tiveram como grupo controle lactantes não vacinadas. Utilizaram-se os Descritores em Ciências da Saúde (DeCs), Medical Subject Heading (MeSH) e Emtree para as bases Biblioteca Virtual em Saúde (BVS), Medical Literature Analysis and Retrieval System Online (Medline/PubMed) e Embase, respectivamente. Na Web of Science e Scopus foi feita adaptação da estratégia. Não foram estabelecid as restrições quanto ao período de publicação e idioma. Síntese dos dados: As buscas identificaram 233 registros. Foram excluídos 128 duplicados e 101 fora dos critérios de inclusão, e quatro estudos de coorte foram elegíveis. As lactantes vacinadas com Pfizer-BioNTech e Moderna apresentaram anticorpos contra SARS-CoV-2 no sangue e no leite materno. Conclusões: As mulheres lactantes vacinadas apresentaram níveis mais elevados de imunoglobulina G (IgG) e A (IgA) no soro e no leite materno em comparação com as mulheres não vacinadas. Objetivo SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- dados CRD42021287554 CRD (CRD42021287554 MetaAnalysis Meta PRISMA. PRISMA . (PRISMA) casocontrole caso Utilizaramse Utilizaram se DeCs, DeCs , (DeCs) MeSH (MeSH BVS, BVS (BVS) Medline/PubMed MedlinePubMed Medline PubMed (Medline/PubMed Embase respectivamente estratégia idioma 23 registros 12 10 inclusão PfizerBioNTech Pfizer BioNTech Conclusões IgG (IgG IgA (IgA SARS-CoV CRD4202128755 (CRD4202128755 (PRISMA (DeCs (BVS 1 CRD420212875 (CRD420212875 CRD42021287 (CRD42021287 CRD4202128 (CRD4202128 CRD420212 (CRD420212 CRD42021 (CRD42021 CRD4202 (CRD4202 CRD420 (CRD420 CRD42 (CRD42 CRD4 (CRD4 (CRD

ABSTRACT Objective: To compare the presence of neutralizing antibodies against SARS-CoV-2 found in the breast milk and blood of vaccinated lactating women with those not vaccinated. Data source: The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021287554 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort, case-control, and cross-sectional studies that evaluated antibodies against SARS-CoV-2 in the milk and blood of vaccinated mothers and had as control group unvaccinated mothers were eligible. Health Sciences Descriptors (DeCs), Medical Subject Headings (MeSH) and Emtree descriptors were used for the Virtual Health Library (VHL), Medical Literature Analysis and Retrieval System Online (Medline/Pubmed), and Embase databases, respectively. In the Web of Science and Scopus, the strategy was adapted. No restrictions on the publication period and language were set. Data synthesis: The search identified 233 records, of which 128 duplicates and 101 papers that did not meet the inclusion criteria were excluded. Hence, four cohort studies were eligible. Nursing mothers vaccinated with the Pfizer-BioNTech and Moderna vaccines showed antibodies against SARS-CoV-2 in their blood and breast milk. Conclusions: Vaccinated lactating women had higher levels of immunoglobulin G (IgG) and A (IgA) in serum and breast milk than unvaccinated women. Objective SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- source PROSPERO (PROSPERO CRD CRD4202128755 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines Cohort casecontrol, casecontrol case control, case-control crosssectional cross sectional eligible DeCs, DeCs , (DeCs) MeSH (MeSH VHL, VHL (VHL) Medline/Pubmed, MedlinePubmed Medline/Pubmed Medline Pubmed (Medline/Pubmed) databases respectively Scopus adapted set synthesis 23 records 12 10 excluded Hence PfizerBioNTech Pfizer BioNTech Conclusions IgG (IgG IgA (IgA SARS-CoV CRD420212875 (DeCs (VHL (Medline/Pubmed 1 CRD42021287 CRD4202128 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Descrever como aplicativos de smartphone podem contribuir para o gerenciamento de quadros de epilepsia em crianças e adolescentes. Fontes de dados: Trata-se de uma revisão integrativa realizada nas bases de dados Medline; PubMed e SciELO, com base nos descritores “epilepsy” e “smartphone”. Foram incluídos estudos originais publicados entre 2017–2023 em português ou inglês que respondessem à pergunta de investigação. Teses e dissertações, estudos duplicados, revisões de literatura e estudos que não responderam à questão de pesquisa foram excluídos. Síntese dos dados: Foram localizados 178 estudos, dos quais seis foram selecionados para compor esta revisão. A amostra incluiu 731 participantes (631 infantojuvenis com epilepsia e 100 cuidadores). Os aplicativos permitem a coleta da frequência de convulsões; momento e o tipo de crise; lembretes para a administração de medicamentos; e informações sobre a qualidade do sono, sendo capazes de armazenar esses dados para profissionais da saúde, cuidadores e usuários acompanharem a evolução do quadro. Conclusões: O uso de aplicativos no manejo das convulsões de crianças e adolescentes com epilepsia apresenta resultados promissores ao promoverem um monitoramento contínuo e personalizado. Novos estudos são necessários para otimizar os resultados benéficos e superar desafios. Objetivo Tratase Trata se Medline SciELO epilepsy “epilepsy smartphone. . “smartphone” 20172023 2017 2023 2017–202 investigação dissertações duplicados excluídos 17 73 631 (63 10 cuidadores. cuidadores) crise medicamentos sono saúde quadro Conclusões personalizado desafios “smartphone 2017202 201 202 2017–20 1 7 63 (6 201720 20 2017–2 6 ( 20172 2 2017–

ABSTRACT Objective: To describe how smartphone applications can contribute to the management of epilepsy in children and adolescents. Data source: This is an integrative review conducted on the Medline, PubMed, and SciELO databases, based on the descriptors “epilepsy” and “smartphone.” Original studies published between 2017–2023 in Portuguese or English that addressed the research question were included. Theses and dissertations, duplicate studies, literature reviews, and studies that did not answer the research question were excluded. Data synthesis: A total of 178 studies were located, of which six were selected for this review. The sample included 731 participants (631 children and adolescents with epilepsy and 100 caregivers). The applications allow for the collection of seizure frequency; timing and type of crisis; reminders for medication administration; and information about sleep quality. They can store these data for healthcare professionals, caregivers, and users to monitor the progress of the condition. Conclusions: The use of applications in managing seizures in children and adolescents with epilepsy shows promising results by promoting continuous and personalized monitoring. Further studies are needed to optimize beneficial outcomes and overcome challenges. Objective source Medline PubMed databases “epilepsy smartphone. “smartphone. 20172023 2017 2023 2017–202 dissertations reviews excluded synthesis 17 located 73 631 (63 10 caregivers. caregivers . caregivers) frequency crisis administration quality professionals condition Conclusions monitoring challenges “smartphone 2017202 201 202 2017–20 1 7 63 (6 201720 20 2017–2 6 ( 20172 2 2017–