This work developed an effective and eco-friendly analytical method to support quality control for Brazilian Bill proposal No. 5332/2009. The bill advocates the creation of the “Brazilian bread” by mandating the incorporation of cassava byproducts into wheat flour, with the aim of reducing Brazil’s external dependency on wheat imports and promoting domestic cassava family farming. For this, a handheld near-infrared (NIR) spectrophotometer was utilized for on-site determination of cassava starch in commercial wheat flour. The quantitative analysis, which utilized NIR spectra pre-processed with offset correction (OFF) combined with linear baseline correction (LBC), alongside the successive projections algorithm for interval selection in partial least squares (iSPA-PLS), exhibited superior predictive capability, achieving a relative error of prediction below 8%. Furthermore, the classification process, which involved NIR spectra pre-processed with LBC and iSPA-PLS for discriminant analysis (iSPA-PLS-DA), yielded an impressive 94% overall accuracy, with only 3 misclassifications in the test set. ecofriendly eco friendly No 53322009 5332 2009 5332/2009 bread flour Brazils Brazil s farming this nearinfrared near infrared (NIR onsite site preprocessed pre processed OFF (OFF LBC, , (LBC) iSPAPLS, iSPAPLS iSPA PLS (iSPA-PLS) capability 8 8% Furthermore process iSPAPLSDA, iSPAPLSDA DA (iSPA-PLS-DA) 94 accuracy set 5332200 533 200 5332/200 (LBC (iSPA-PLS (iSPA-PLS-DA 9 533220 53 20 5332/20 53322 5 2 5332/2 5332/

We created a fast and effective thin-layer chromatography method to detect homoisoflavones in Polygonatum odoratum (Mill.) Druce (POD), demonstrating high sensitivity, specificity, and stability. Utilizing this method, we assessed the quality of 20 commercial batches of POD. Our results indicated that homoisoflavones (III, IV, and V) were present in 8 samples, absent in 7, and detected in 5. This method facilitates the effective evaluation of POD germplasm resources, laying a strong foundation for enhancing quality standards. This advancement aids in the standardization and quality control of POD, ensuring the consistency of its active ingredients and thereby supporting its therapeutic applications. thinlayer thin layer Mill. Mill (Mill. , (POD) sensitivity specificity stability 2 III, III (III IV V samples 7 5 resources standards applications (Mill (POD

ABSTRACT The estimation of evapotranspiration (ET) and crop water requirements are crucial for the proper management and allocation of water resources in terms of quantity, quality, and timeliness. Therefore, remote sensing estimation of ET using the SEBAL algorithm (Surface Energy Balance Algorithm for Land) can provide spatio-temporal, non-punctual data, unlike traditional calculations relying on the nearest meteorological station. This research analyzed ET using SEBAL, based on ten Landsat 8 satellite images processed with a program developed in the Model Builder of ArcGis® version 10.2. The analysis was conducted during the vegetative period of starchy corn from May to October 2016. Validation of the results happened with a drainage lysimeter installed in a monitoring plot. Additionally, the statistical indices - such as percentage relative error (PRE) (0,09), root mean square error (RMSE) (0,30), R2 (0,92), and Nash-Sutcliffe efficiency (NASH) (0,91) - indicated a good correlation of ET for starchy corn in the central highlands of Peru. The ET identified at ten monitoring points ranged from 1,05 to 7,79 mm d-1. (ET quantity quality timeliness Therefore Surface Land spatiotemporal, spatiotemporal spatio temporal, temporal spatio-temporal nonpunctual non punctual data station ArcGis 102 10 2 10.2 2016 plot Additionally PRE (PRE 0,09, 009 0,09 , 0 09 (0,09) RMSE (RMSE 0,30, 030 0,30 30 (0,30) R 0,92, 092 0,92 92 (0,92) NashSutcliffe Nash Sutcliffe NASH (NASH 0,91 091 91 (0,91 Peru 105 1 05 1,0 779 7 79 7,7 d1. d1 d 1. d-1 10. 201 00 0,0 (0,09 03 0,3 3 (0,30 0,9 9 (0,92 (0,9 1, 77 7, d- 20 0, (0,0 (0,3 (0, (0 (

ABSTRACT Proper waste management is a major worldwide concern; waste is disposed of directly into the environment, affecting water, soil and air quality. The development and production of green energy sources is strongly encouraged in modern society. The aim of this study, in accordance with Sustainable Development Goals (SDGs) 1, 2 and 7 of the 2030 Agenda of the UN, is to combine the correct disposal of animal waste with the generation of energy to mitigate the energy insecurity of families in an extremely vulnerable semi-arid region in the north-east of the country using biodigesters. To this end, a conceptual proposal was drawn up for a low-cost, easy-to-maintain and easy-to-use biodigester. A small-scale prototype was used to assess its operation by evaluating the main factors that affect biogas production (pH, temperature and the biomass properties: total solids, fixed solids, volatile solids, concentration of volatile fatty acids and C/N ratio). Evaluation of the test prototype gave satisfactory results that corroborate other studies and make it possible to propose an economically viable and efficient full-scale biodigester for biogas production. concern environment water quality society study SDGs (SDGs 1 203 UN semiarid semi arid northeast north east biodigesters end lowcost, lowcost low cost, cost low-cost easytomaintain easy maintain easytouse use smallscale small scale pH, pH (pH properties solids CN C N ratio. ratio . ratio) fullscale full 20

ABSTRACT Chia (Salvia hispanica L.) seeds have attracted great economic interest for their high levels of linoleic and α-linolenic acids. In Brazil, there is a lack of studies on the agronomic characteristics and physiological quality of chia, necessitating research on germination processes and strategies to enhance yield under field conditions. There are no studies assessing the development of seeds with different coat colors in the presence of fungicides. This study aimed to assess the physiological quality of chia seeds as a function of coat color and fungicide treatment. The experiment followed a completely randomized design with a 2 × 2 factorial arrangement and six replications. For this, seeds were divided into two groups according to coat color (black and white) and subjected or not to treatment with carboxin + thiram. Germination speed index, germination rate, and shoot length were evaluated in plants sown at 0, 90, and 180 days after seed treatment. Germination rate and speed index differed significantly between coat colors, with white seeds having higher vigor than black seeds. Shoot length, however, differed only for seeds sown on the day of treatment, indicating that treated seeds were more vigorous. Salvia L. L αlinolenic α linolenic acids Brazil conditions fungicides replications this thiram 0 90 18 however vigorous 9 1

The increase in the average temperature of the Earth due to excess CO2 and other greenhouse gases has caused glaciers to melt and sea levels to rise. The burning of fossil fuels is one of the main causes of this problem, so the use of biofuels is important for mitigating this environmental impact. In Brazil, biodiesel is mixed with mineral; however, irregularities have been detected, reducing the expected positive effects. Therefore, this study proposes the use of multivariate curve resolution with alternating least squares (MCR ALS) to quantify the content of methyl palm oil biodiesel in diesel blends and determine the concentration of the adulterant automotive lubricating oil in the blend. The model for quantifying biodiesel in diesel obtained R2 = 0.9997, root mean square error of calibration (RMSEC) = 0.56% (v v-1) and prediction (RMSEP) = 0.65% (v v-1), while the determination of adulteration in the biodiesel-diesel blend showed RMSEC = 0.67% (v v-1), RMSEP = 0.81% (v v-1) and R2 = 0.9992. These results demonstrate the ability of the models developed to predict both the content and quantity of possible adulterants in blends of palm oil biodiesel and mineral diesel, contributing to the quality control of this fuel. CO rise problem impact Brazil however detected effects Therefore MCR ALS R 09997 0 9997 0.9997 (RMSEC 056 56 0.56 v v1 1 v-1 (RMSEP 065 65 0.65 v1, , biodieseldiesel 067 67 0.67 081 81 0.81 09992 9992 0.9992 fuel 0999 999 0.999 05 5 0.5 v- 06 6 0.6 08 8 0.8 099 99 0.99 0. 09 9 0.9

ABSTRACT Objective: The aim of this study was to investigate the contextual factors associated with the quality of life (QOL) of Brazilian children aged 0–12 years during the strict period of social isolation. Methods: This observational cross-sectional study was conducted between July and September 2020 using an online questionnaire on QOL-related family factors and the Pediatric Quality of Life Inventory (PedsQL™). Results were analyzed by multinomial logistic regression analysis. Results: The sample had 849 children, mostly from the South Region of Brazil (75%), white (83%), with typical development (79%), sedentary (68%), using screen (85%) for >3 h/day (44%). Their mothers were their main caregivers (90%). The following variables were significantly associated with high scores of QOL: typical health status (OR 2.38; 95%CI 1.60–3.55; screen time ≤2 h/day (OR 1.62; 95%CI 1.17–2.24); social distancing considered as “easy” (OR 1.67; 95%CI 1.20–2.32), and stimulation of the child by the family (OR 1.93; 95%CI 1.08–3.45). Conclusions: This study indicates that the family context can influence children’s QOL, especially during the COVID-19 pandemic and home environment reorganization. Objective QOL (QOL 012 0 12 0–1 isolation Methods crosssectional cross sectional 202 QOLrelated related PedsQL™. PedsQL PedsQL™ . (PedsQL™) analysis 84 75%, 75 75% , (75%) 83%, 83 83% (83%) 79%, 79 79% (79%) 68%, 68 68% (68%) 85% 85 (85% 3 > hday h day 44%. 44 44% (44%) 90%. 90 90% (90%) OR 2.38 238 2 38 95CI CI 95 1.60–3.55 160355 1 60 55 ≤ 1.62 162 62 1.17–2.24 117224 17 24 1.17–2.24) easy “easy 1.67 167 67 1.20–2.32, 120232 1.20–2.32 20 32 1.20–2.32) 1.93 193 93 1.08–3.45. 108345 1.08–3.45 08 45 1.08–3.45) Conclusions childrens s COVID19 COVID 19 COVID-1 reorganization 01 0– (PedsQL™ 8 7 (75% (83% (79% 6 (68% (85 4 (44% 9 (90% 2.3 23 1.60–3.5 16035 5 1.6 16 1.17–2.2 11722 12023 1.20–2.3 1.9 10834 1.08–3.4 COVID1 COVID- (PedsQL (75 (83 (79 (68 (8 (44 (90 2. 1.60–3. 1603 1. 1.17–2. 1172 1202 1.20–2. 1083 1.08–3. (7 (6 ( (4 (9 1.60–3 160 1.17–2 117 120 1.20–2 108 1.08–3 1.60– 1.17– 11 1.20– 10 1.08– 1.60 1.17 1.20 1.08 1.1 1.2 1.0

RESUMO Objetivo: Investigar os fatores contextuais associados à qualidade de vida (QV) de crianças brasileiras de zero a 12 anos, em momento de ápice de distanciamento social. Métodos: Estudo observacional, transversal, online, de julho a setembro de 2020, com questionário sobre fatores do contexto familiar associados à QV e Inventário Pediátrico sobre QV — PedsQL™. A análise dos dados foi feita por de regressão logística multinomial. Resultados: A amostra foi de 849 crianças, na maioria da Região Sul (75%), brancas (83%), com desenvolvimento típico (79%), sedentárias (68%), com uso de telas (85%) em tempo >3h/dia (44%). As mães eram as cuidadoras principais (90%). Foram significativamente associadas a escores mais elevados de QV: a condição de saúde típica (odds ratio — OR 2,38; intervalo de confiança de 95% — IC95% 1,60–3,55), o tempo de tela ≤2h/dia (OR 1,62; IC95% 1,17–2,24), o distanciamento social considerado “fácil” (OR 1,67; IC95% 1,20–2,32) e a família afirmar estimular a criança (OR 1,93; IC95% 1,08–3,45). Conclusões: Este estudo mostra que o contexto familiar pode influenciar a QV de crianças, especialmente no período de pandemia e de reorganização do ambiente domiciliar. Objetivo (QV 1 anos Métodos observacional transversal online 2020 PedsQL PedsQL™ multinomial Resultados 84 75%, 75 75% , (75%) 83%, 83 83% (83%) 79%, 79 79% (79%) 68%, 68 68% (68%) 85% 85 (85% 3hdia hdia 3h dia h 44%. 44 44% . (44%) 90%. 90 90% (90%) odds 2,38 238 2 38 95 IC95 IC 1,60–3,55, 160355 1,60–3,55 60 3 55 1,60–3,55) 2hdia 2h 1,62 162 62 1,17–2,24, 117224 1,17–2,24 17 24 1,17–2,24) fácil “fácil 1,67 167 67 1,20–2,32 120232 20 32 1,93 193 93 1,08–3,45. 108345 1,08–3,45 08 45 1,08–3,45) Conclusões domiciliar 202 8 7 (75% (83% (79% 6 (68% (85 4 (44% 9 (90% 2,3 23 IC9 16035 1,60–3,5 5 1,6 16 11722 1,17–2,2 1,20–2,3 12023 1,9 19 10834 1,08–3,4 0 (75 (83 (79 (68 (8 (44 (90 2, 1603 1,60–3, 1, 1172 1,17–2, 1,20–2, 1202 1083 1,08–3, (7 (6 ( (4 (9 160 1,60–3 117 1,17–2 1,20–2 120 108 1,08–3 1,60– 11 1,17– 1,20– 10 1,08– 1,60 1,17 1,20 1,08 1,1 1,2 1,0

APPLICATION OF MASS SPECTROMETRY WITH PAPER SPRAY IONIZATION AND THE OPLS-DA CHEMOMETRIC METHOD FOR THE DIAGNOSIS OF PROSTATE CANCER BY ANALYSIS OF URINE SAMPLES. In this study, paper spray ionization mass spectrometry (PSI-MS) allied to orthogonal projections on the latent structure-discrimination analysis (OPLS-DA) was employed to differentiate urine samples from patients with prostate cancer and control individuals (without prostate cancer). The parameters of sensitivity, specificity, efficiency and Matthew’s correlation coefficient determined to analyze the efficiency and quality of the OPLS-DA model obtained a value equal to 1, which means, respectively, that the model has a good performance to correctly classify true positive samples and true negatives. These results showed 100% correct classification of the samples from the training and test set, demonstrating a high efficiency of the OPLS-DA model when classifying all samples considered as belonging to the class of interest (urine from control patient) into class 1 and all samples considered as belonging to the non-interest class (urine from patients with prostate cancer) in class 0. This efficiency resulting from the application of this model suggests that the PSI-MS combined to OPLS-DA is a promisor approach for a rapid diagnosis of prostate cancer, via chemical fingerprints of urine samples. OPLSDA OPLS DA SAMPLES study PSIMS PSI MS (PSI-MS structurediscrimination structure discrimination (OPLS-DA without cancer. . sensitivity specificity Matthews Matthew s means respectively negatives 100 set patient noninterest non 0 10

ABSTRACT Purpose: This prospective, randomized, unmasked, clinical trial aimed to report the visual outcomes of cataract surgery on both eyes versus cataract surgery on one eye in Brazilian patients. Methods: This study included patients with bilateral cataracts and binocular visual acuity worse than or equal to 0.3 logarithm of the minimum angle of resolution. The patients were randomly assigned to undergo surgery on one (Control Group) or both eyes (one eye at a time; Intervention Group). Postoperatively, self-reported visual function using Catquest-9SF (primary outcome measure), binocular visual acuity, stereopsis, and ocular dominance (secondary outcome measures) were compared. Results: A total of 151 patients (77 and 148 eyes in the Control and Intervention Groups, respectively) completed the follow-up. Patients who underwent surgery on both eyes exhibited significantly better self-reported visual function (p=0.036) and stereopsis (p=0.026) than those who underwent surgery on one eye. Binocular visual acuity and ocular dominance did not affect the group comparisons. Conclusions: Surgery on both eyes resulted in significantly better self-reported visual function and stereopsis than surgery on one eye. Purpose prospective randomized unmasked Methods 03 0 3 0. resolution Group time Group. . Postoperatively selfreported self reported Catquest9SF CatquestSF Catquest 9SF SF primary measure, measure , measure) secondary measures compared Results 15 77 (7 14 Groups respectively followup. followup follow up. up follow-up p=0.036 p0036 p 036 (p=0.036 p=0.026 p0026 026 (p=0.026 comparisons Conclusions 1 7 ( p=0.03 p003 (p=0.03 p=0.02 p002 02 (p=0.02 p=0.0 p00 (p=0.0 p=0. p0 (p=0. p=0 (p=0 p= (p= (p

ABSTRACT Langerhans cell histiocytosis comprises a heterogeneous range of clinical manifestations secondary to clonal proliferation of histiocytes, characterized by the accumulation of these cells in various organs and tissues. The ophthalmological component commonly involved is the orbit. Herein, we report a rare case of Langerhans cell histiocytosis with eyelid involvement, which resulted in severe ocular surface complications, which subsequently significantly impacted the patient’s quality of life. This case report highlights the fact that despite being rare, Langerhans cell histiocytosis should be included in the differential diagnosis of eyelid lesions. Furthermore, a multidisciplinary approach with a systemic overview is crucial for managing the ocular complications. histiocytes tissues orbit Herein involvement complications patients patient s life lesions Furthermore

Over the last two decades, metabolomics has emerged as a pivotal tool in multidisciplinary research, providing invaluable insights into metabolome modulations and finding applications across various scientific domains, including medicine and agronomy. Nonetheless, the absence of standardized procedures in sample preparation, data acquisition, and documentation of data quality presents a significant challenge. This review underscores the critical importance of quality assurance and quality control (QA/QC) in untargeted metabolomics, advocating for the establishment of agreed-upon QA/QC reporting standards within the scientific community. We discuss the requisite quality controls at various stages of untargeted metabolomics studies, encompassing blank samples, pooled samples, and the utilization of external quality control samples. Methods for assessing accuracy, reproducibility, and identifying/correcting batch effects are addressed. Furthermore, emphasis is placed on standardizing the description of QA/QC data in scientific publications and repositories to foster reproducibility and transparency. We recommend the publication of QC data alongside studies in appropriate databases to facilitate data comparison and sharing among researchers, thereby enhancing the quality of untargeted metabolomics research. In summary, implementing standardized QA/QC data reporting, along with promoting best practices within the untargeted metabolomics community, is crucial for improving result quality and credibility and advancing research utilizing this powerful technique. decades domains agronomy Nonetheless preparation acquisition challenge QAQC QA (QA/QC agreedupon agreed upon community samples accuracy identifyingcorrecting identifying correcting addressed Furthermore transparency researchers summary technique

RESUMO Regiões com climas semiáridos apresentam condições ambientais que resultam em estresses abióticos às plantas. A maior área de produção de melão (Cucumis melo L.) do Brasil, o Estado do Rio Grande do Norte, possui essas características climáticas. O uso de bioestimulantes nesses sistemas de produção pode mitigar os efeitos dos estresses abióticos e aumentar a produtividade e a qualidade dos frutos. O objetivo neste estudo foi avaliar as características fisiológicas e de produção do meloeiro, sob aplicação de bioestimulantes. Os bioestimulantes Acadian®, Folicist® e Nov@® foram aplicados e comparados ao tratamento controle (sem bioestimulantes), em melões ‘Goldex’ e ‘McLaren’. Nov@® proporcionou maior assimilação de CO2, transpiração e condutância estomática, assim como ascorbato peroxidase em ‘Goldex’ e ‘McLaren’. Maior catalase foi obtida pela aplicação de Nov@®, enquanto que o uso de Folicist® resultou em maior teor de malondialdeído. A cultivar McLaren apresentou o melhor desempenho fisiológico e bioquímico e a ‘Goldex’ o melhor rendimento. Folicist® promove adaptações fisiológicas aos estresses sem prejudicar a atividade fotossintética. Os bioestimulantes aumentaram a produtividade e o número de frutos por planta e promoveram adaptações fisiológicas às condições semiáridas. plantas Cucumis L. L Brasil Norte climáticas meloeiro Acadian Acadian® Folicist Nov Nov@ bioestimulantes, , bioestimulantes) ‘Goldex Goldex ‘McLaren. ‘McLaren . ‘McLaren’ CO2 CO estomática malondialdeído rendimento fotossintética semiáridas

ABSTRACT Regions with semi-arid climates have environmental conditions that result in abiotic stress to plants. The largest melon (Cucumis melo L.) production area in Brazil, the state of Rio Grande do Norte, has these climatic characteristics. Use of biostimulants in these production systems can mitigate effects of abiotic stress and increase yield and fruit quality. The objective in this study was to evaluate the physiological and production characteristics of melon, under the application of biostimulants. The biostimulants Acadian®, Folicist® and Nov@® were applied and compared to the control treatment (no biostimulants), in ‘Goldex’ and ‘McLaren’ melons. Nov@® led to higher CO2 assimilation, transpiration and stomatal conductance, as well as ascorbate peroxidase, in ‘Goldex’ and ‘McLaren’. Greater catalase was obtained with the application of Nov@®, while the use of Folicist® resulted in higher malondialdehyde content. The cultivar ‘McLaren’ exhibited the best physiological and biochemical performance, and ‘Goldex’ the best yield. Folicist® promotes physiological adaptations to stress without impairing photosynthetic activity. The biostimulants increased yield and number of fruits per plant and promoted physiological adaptations to semi-arid conditions. semiarid semi arid plants Cucumis L. L Brazil Norte quality Acadian Acadian® Folicist Nov Nov@ no biostimulants, , biostimulants) ‘Goldex Goldex ‘McLaren McLaren melons CO assimilation conductance peroxidase ‘McLaren. . content performance activity

RESUMO A densidade de plantas e o espaçamento correto são fatores fundamentais para alcançar produtividade rentável e qualidade dos frutos em culturas agrícolas. Este estudo teve como objetivo avaliar a produtividade do tomateiro de crescimento determinado e as características físico-químicas dos frutos, em diferentes arranjos de plantio e densidades de plantas. Foram realizados dois experimentos, sendo que no primeiro experimento e no segundo experimento foram utilizados os híbridos CVR-2909 (CVR Plant Breeding) e HMX 7885 (Agristar), respectivamente. Os experimentos foram conduzidos em delineamento de blocos casualizados, com quatro repetições. Foram avaliados dez tratamentos em esquema fatorial duplo (2 × 5). No primeiro fator, foram avaliados dois arranjos de plantio: linhas simples e linhas duplas. No segundo fator, foram avaliadas cinco densidades de plantas: 15, 20, 25, 30 e 35 mil plantas ha-1. Para o híbrido CVR-2909, o cultivo em linhas simples proporcionou maior produtividade, já as maiores densidades de plantas resultaram em menor produção e número de frutos por planta. Para o híbrido HMX-7885, maiores densidades de plantas proporcionaram maior produtividade, porém com menor produção por planta, massa média e número de frutos por planta. Para esse híbrido o arranjo de plantio proporcionou maior taxa de frutos verdes. agrícolas físicoquímicas físico químicas CVR2909 CVR 2909 CVR-290 Breeding 788 Agristar, Agristar , (Agristar) respectivamente casualizados repetições 2 ( 5. 5 . 5) fator duplas 15 20 25 3 ha1. ha1 ha 1. 1 ha-1 CVR2909, 2909, planta HMX7885, HMX7885 7885, HMX-7885 verdes CVR290 290 CVR-29 78 (Agristar ha- HMX788 HMX-788 CVR29 29 CVR-2 7 HMX78 HMX-78 CVR2 CVR- HMX7 HMX-7 HMX-

ABSTRACT Plant density and correct row spacing are fundamental factors for achieving profitable yield and fruit quality in crops. This study aimed to evaluate the yield of tomato plants of determinate growth and the physicochemical characteristics of the fruits in different planting arrangements and plant densities. Two experiments were conducted using the hybrids CVR-2909 (CVR Plant Breeding) and HMX 7885 (Agristar) in the first and second experiments, respectively. The experiments were conducted in a randomized block design with four replicates. Ten treatments were evaluated in a double factorial scheme (2 × 5). Two planting arrangements were evaluated in the first factor: single and double rows. The second factor comprised five plant densities: 15, 20, 25, 30, and 35 thousand plants ha-1. For the CVR-2909 hybrid, single-row cultivation resulted in the highest yield, while higher planting densities gave the lowest yield and number of fruits per plant. For the HMX-7885 hybrid, it was found that higher densities gave higher yields but caused a decreasing effect on fruit production per plant, average fruit mass, and number of fruits per plant. For this hybrid, the planting arrangement provided a higher rate of green fruits. crops CVR2909 CVR 2909 CVR-290 Breeding 788 Agristar (Agristar respectively replicates 2 ( 5. 5 . 5) rows 15 20 25 30 3 ha1. ha1 ha 1. 1 ha-1 hybrid singlerow HMX7885 HMX-788 mass CVR290 290 CVR-29 78 ha- HMX788 HMX-78 CVR29 29 CVR-2 7 HMX78 HMX-7 CVR2 CVR- HMX7 HMX-

To control vehicle emissions, the new homologation process must be reported according to the California Maximum Incremental Reactivity (MIR) scale’s procedure to calculate the ozone forming potential (OFP) of each new vehicle. This work calculates an MIR scale suitable for the Brazilian reality. Meteorological and hourly pollutant data from the Bangu Automatic Air Quality Station was inventoried and processed from March to September 2020 to adjust OZIPR Lagrangean model and obtain the MIR scale by making small increments in the concentrations of each volatile organic compounds (VOC) and calculate the ozone increase/decrease. It was found that the VOC that had the greatest impact on ozone formation was 1,2,4-trimethylbenzene, with 2.06 ppb O3 ppbC-1 VOC. The OFP was calculated based on the VOC emissions of a vehicle and it was found a value of 9.421 mg O3 km-1, a much lower value when compared using the California MIR scale of 136.608 mg O3 km-1. It is concluded that meteorological conditions and VOC speciation data in the air mixture in the studied region directly affect the photochemical reactions of ozone formation. (MIR scales s (OFP reality 202 (VOC increasedecrease increase decrease increase/decrease 1,2,4trimethylbenzene, 124trimethylbenzene trimethylbenzene 1,2,4 trimethylbenzene, 1 2 4 1,2,4-trimethylbenzene 206 06 2.0 O ppbC1 ppbC ppbC- 9421 9 421 9.42 km1, km1 km 1, km-1 136608 136 608 136.60 km1. 1. 20 4trimethylbenzene 1,2,4trimethylbenzene 124 1,2, 0 2. 942 42 9.4 km- 13660 13 60 136.6 12 1,2 94 9. 1366 6 136.

RESUMO Objetivo: Descrever como aplicativos de smartphone podem contribuir para o gerenciamento de quadros de epilepsia em crianças e adolescentes. Fontes de dados: Trata-se de uma revisão integrativa realizada nas bases de dados Medline; PubMed e SciELO, com base nos descritores “epilepsy” e “smartphone”. Foram incluídos estudos originais publicados entre 2017–2023 em português ou inglês que respondessem à pergunta de investigação. Teses e dissertações, estudos duplicados, revisões de literatura e estudos que não responderam à questão de pesquisa foram excluídos. Síntese dos dados: Foram localizados 178 estudos, dos quais seis foram selecionados para compor esta revisão. A amostra incluiu 731 participantes (631 infantojuvenis com epilepsia e 100 cuidadores). Os aplicativos permitem a coleta da frequência de convulsões; momento e o tipo de crise; lembretes para a administração de medicamentos; e informações sobre a qualidade do sono, sendo capazes de armazenar esses dados para profissionais da saúde, cuidadores e usuários acompanharem a evolução do quadro. Conclusões: O uso de aplicativos no manejo das convulsões de crianças e adolescentes com epilepsia apresenta resultados promissores ao promoverem um monitoramento contínuo e personalizado. Novos estudos são necessários para otimizar os resultados benéficos e superar desafios. Objetivo Tratase Trata se Medline SciELO epilepsy “epilepsy smartphone. . “smartphone” 20172023 2017 2023 2017–202 investigação dissertações duplicados excluídos 17 73 631 (63 10 cuidadores. cuidadores) crise medicamentos sono saúde quadro Conclusões personalizado desafios “smartphone 2017202 201 202 2017–20 1 7 63 (6 201720 20 2017–2 6 ( 20172 2 2017–

ABSTRACT Objective: To describe how smartphone applications can contribute to the management of epilepsy in children and adolescents. Data source: This is an integrative review conducted on the Medline, PubMed, and SciELO databases, based on the descriptors “epilepsy” and “smartphone.” Original studies published between 2017–2023 in Portuguese or English that addressed the research question were included. Theses and dissertations, duplicate studies, literature reviews, and studies that did not answer the research question were excluded. Data synthesis: A total of 178 studies were located, of which six were selected for this review. The sample included 731 participants (631 children and adolescents with epilepsy and 100 caregivers). The applications allow for the collection of seizure frequency; timing and type of crisis; reminders for medication administration; and information about sleep quality. They can store these data for healthcare professionals, caregivers, and users to monitor the progress of the condition. Conclusions: The use of applications in managing seizures in children and adolescents with epilepsy shows promising results by promoting continuous and personalized monitoring. Further studies are needed to optimize beneficial outcomes and overcome challenges. Objective source Medline PubMed databases “epilepsy smartphone. “smartphone. 20172023 2017 2023 2017–202 dissertations reviews excluded synthesis 17 located 73 631 (63 10 caregivers. caregivers . caregivers) frequency crisis administration quality professionals condition Conclusions monitoring challenges “smartphone 2017202 201 202 2017–20 1 7 63 (6 201720 20 2017–2 6 ( 20172 2 2017–