Abstract: Passive Optical Networks (PONs) are essential in optical communications to meet the increasing demand for network capacity and connected users, ensuring reliable and adaptable connections for data transmissions. These networks also simplify infrastructures and efficiently utilize energy by eliminating the need for active devices. In this context, Ultra- Dense Wavelength Division Multiplexing (UDWDM) is one of the most prominent solutions for data transmission. This technology uses the narrow separation between channels from 25GHz and even as small as 6.25GHz to increase the transmission capacity. This document analyzes the performance of UDWDM considering the transmission of three simultaneous channels in a PON network for which three different scenarios have been considered for the analysis with the following parameters: i) transmission speed from 10 Gbps to 17 Gbps, ii) the distance from 10 km to 20 km and iii) the separation between channels of 15GHz, 20GHz, and 25GHz. The performance metrics for the analyzed scenario are the bit error rate and the eye diagram. To ensure the reception of the transmitted channel, an analysis of raised cosine and Gauss filters is also discussed. Including these filters allows for verifying whether their use enhances the performance of the channels compared to transmission without a filter. This is crucial for understanding how filters can optimize the quality and reliability of data transmission in a PON, which is of great importance in environments where high efficiency and connection quality are required.

Resumen: Las redes ópticas pasivas (PON) son esenciales en las comunicaciones ópticas para satisfacer la creciente demanda de capacidad de red y usuarios conectados, garantizando conexiones fiables y adaptables para la transmisión de datos. Estas redes también ofrecen un uso eficiente de la energía y la simplificación de las infraestructuras, eliminando la necesidad de dispositivos activos. En este contexto, la multiplexación por división de longitud de onda ultradensa (UDWDM) es una de las soluciones más destacadas para la transmisión de datos; esta tecnología aprovecha la estrecha separación entre canales a partir de 25GHz e incluso de tan solo 6,25GHz para aumentar la capacidad de transmisión. Este documento analiza el rendimiento de UDWDM considerando la transmisión de tres canales simultáneos en una red PON para la que se han considerado tres escenarios diferentes para el análisis con los siguientes parámetros: i) velocidad de transmisión de 10 Gbps a 17 Gbps; ii) la distancia de 10 km a 20 km; y iii) la separación entre canales de 15GHz, 20GHz, y 25GHz. Las métricas de rendimiento para el escenario analizado son la tasa de errores de bit y el diagrama de ojo. Para garantizar la recepción del canal transmitido, también se analiza la utilización de filtros coseno elevado y Gauss. La inclusión de estos filtros permite comprobar si su uso mejora el rendimiento de los canales en comparación con la transmisión sin filtro. Esto es crucial para entender cómo los filtros pueden optimizar la calidad y fiabilidad de la transmisión de datos en una PON, lo que es de gran importancia en entornos donde se requiere una alta eficiencia y calidad de conexión.

ABSTRACT Objective: To study associations between polymorphisms in the angiotensin converting enzyme (ACE I/D), actinin 3 (ACTN3 R577X) and paraoxonase 1 (PON1 T(-107)C) genes and chronic diseases (diabetes and hypertension) in women. Materials and methods: Genomic DNA was extracted from saliva samples of 78 women between 18 and 59 years old used for genetic polymorphism screening. Biochemical data were collected from the medical records in Basic Health Units from Southern Brazil. Questionnaires about food consumption, physical activity level and socioeconomic status were applied. Results: The XX genotype of ACTN3 was associated with low HDL levels and high triglycerides, total cholesterol and glucose levels. Additionally, high triglycerides and LDL levels were observed in carriers of the TT genotype of PON1, and lower total cholesterol levels were associated to the CC genotype. As expected, women with diabetes/hypertense had increased body weight, BMI (p = 0.02), waist circumference (p = 0.01), body fat percentage, blood pressure (p = 0.02), cholesterol, triglycerides (p = 0.02), and blood glucose (p = 0.01), when compared to the control group. Conclusion: Both ACTN3 R577X and PON1 T(-107)C polymorphisms are associated with nutritional status and blood glucose and lipid levels in women with diabetes/hypertense. These results contribute to genetic knowledge about predisposition to obesity-related diseases. Objective ACE I/D, ID I/D , I D I/D) ACTN (ACTN RX R X PON (PON T107C TC T 107 C diabetes hypertension methods 7 5 screening Brazil consumption applied Results Additionally expected diabeteshypertense hypertense weight p 0.02, 002 0.02 0 02 0.02) 0.01, 001 0.01 01 0.01) percentage group Conclusion obesityrelated obesity related 10 00 0.0 0.

Abstract Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the effects of agomelatine on cisplatin-induced toxicity in the kidney and liver. Animals were administered with a single dose of cisplatin (7 mg/kg, i.p.) and treated with agomelatine (20 and 40 mg/kg, p.o) for seven days. Renal and hepatic functions were evaluated by measuring concentrations of creatinine, BUN, AST and ALT in the serum. Oxidative stress and protein peroxidation were assessed by measuring SOD, CAT, GSH and AOPP levels in both tissues. Serum PON-1 levels were also evaluated. Histopathological analysis was performed to determined structural changes in the kidney and liver. Agomelatine (20 mg/kg) treatment approximately halved cisplatin-related increase in serum creatinine, BUN, AST and ALT levels. Agomelatine (20 mg/kg) significantly prevented the cisplatin-induced excessive decrease in SOD, CAT, GSH in both tissues and serum PON-1 levels. Agomelatine (20 and 40 mg/kg) protected the structural integrity of the kidney against cisplatin-insult. Although agomelatine (40 mg/kg) protected the kidney and showed parallel results with 20 mg/kg biochemically, it failed to show the same liver tissue effects in both analyses. Although agomelatine protected against cisplatin-induced toxicity in the kidney and liver, care should be taken with higher doses for possible hepatotoxicity. chemotherapy study cisplatininduced induced 7 ( mgkg mg kg i.p. ip i p (2 4 p.o po o days creatinine BUN SOD CAT PON1 PON 1 PON- cisplatinrelated related cisplatininsult. cisplatininsult insult. insult cisplatin-insult (4 2 biochemically analyses i.p