ABSTRACT Purpose: This study aimed to evaluate the morphometric and volumetric dimensions of the lacrimal gland in patients with inactive thyroid eye disease and compare them with the values reported in the literature. Methods: This case series evaluated consecutive patients with inactive thyroid eye disease treated at a tertiary eye hospital from 2015 to 2020. The patients’ baseline demographics and clinical characteristics were obtained. The axial and coronal length, width, and volume of the lacrimal gland were measured on computed tomography scan images, and the results were statistically analyzed. Results: A total of 21 patients (42 orbits) with inactive thyroid eye disease were evaluated. Their mean age was 49.0 ± 14.6 years, and 12 (57.1%) of them were men. The main complaint was dryness, and the majority of the patients had good vision and mild proptosis. The mean axial length and width of the lacrimal gland were 19.3 ± 3.9 mm and 7.5 ± 2.1 mm, respectively; coronal length and width, 20.4 ± 4.5 mm and 7.5 ± 2.1 mm, respectively; and lacrimal gland volume, 0.825 ± 0.326 mm3. Age, sex, or laterality were not found to be determinants of lacrimal gland enlargement. Conclusion: Patients with thyroid eye disease have enlarged lacrimal gland even in the nonactive phase of the disease multifactorial aspects influence the lacrimal gland in thyroid eye disease, making it difficult to establish a clear correlation with predisposing factors. Further studies are warranted to better understand the association between thyroid eye disease and the lacrimal gland. Purpose literature Methods 201 2020 obtained images analyzed Results 2 42 (4 orbits 490 49 0 49. 146 14 6 14. years 1 57.1% 571 57 (57.1% men dryness proptosis 193 19 3 19. 39 9 3. 75 7 5 7. 2. respectively 204 20 4 20. 45 4. 0825 825 0.82 0326 326 0.32 mm3 Age sex enlargement Conclusion factors 202 ( 57.1 (57.1 082 82 0.8 032 32 0.3 57. (57. 08 8 0. 03 (57 (5

Abstract Purpose: To analyze diabetes mellitus (DM) in a multifactorial manner with the consumption of sugar-sweetened beverages (SSB) and variables like nutritional status, sex, genetic predisposition, age and ethnicity; in order to determine the relationship between BGA and DM in the Mazahua Otomí (MO) community. Methodological design: This quantitative survey on social and nutritional variables was designed, validated and applied. A logistic model was developed to find the relationship of DM in relation to the variables: SSB consumption, sex, genetic predisposition, age, body mass index and ethnicity. Results: The Mazahua otomi community has a monthly family income below the extreme poverty line; they do not have disease control: 68% are obese or overweight and SSB consumption is medium to high in 90% of the population. In a multifactorial manner and according to the model, there is a probability of manifesting DM depending on the variables mentioned above; while, with the exception of nutritional status and age, the others are the most significant. In taste and preferences, 52% opt for the Coca-Cola SSB brand. Research limitations: The results found should be complemented in other case studies in communities with similar characteristics and a broader probabilistic population sample. Finding: In the MO community there is a relationship between BGA consumption and DM and there is no control of the disease. This work contributes to the design of public policies to prevent health damage because of excessive consumption of SSB and its relationship with DM; likewise, those policies that rescue and promote good nutritional practices of the communities of indigenous peoples.

Resumen Objetivo: Analizar en forma multifactorial la diabetes mellitus (DM) con el consumo de las bebidas gaseosas azucaradas (BGA) y de las variables estado nutricional, sexo, predisposición genética, edad y etnia, para determinar la relación de las BGA y la DM en la comunidad Mazahua Otomí (MO). Diseño Metodológico: El estudio fue cuantitativo. Se diseñó, validó y aplicó una encuesta estructurada sobre variables sociales y nutricionales. Se elaboró un modelo logístico para encontrar la relación de DM con las variables: consumo de BGA, sexo, predisposición genética, edad, índice de masa corporal y etnia. Resultados: En la comunidad MO que se investigó un padre de familia promedio tiene un ingreso mensual por debajo de la línea de pobreza extrema y no existe control de la enfermedad de estudio: 68% tiene obesidad o sobrepeso y el consumo de BGA es entre medio y alto en 90% de la población. En forma multifactorial, hay probabilidad de manifestar la DM en función de las variables antes señaladas; mientras que, a excepción de estado nutricional y la edad, las demás son las más significativas. En gustos y preferencias, 52% opta por la marca de BGA Coca-Cola. Limitaciones de la investigación: Los resultados encontrados deberán complementarse con estudios de caso en comunidades con características similares y una muestra poblacional probabilística más amplia. Hallazgos: En la comunidad MO existe una relación entre el consumo de BGA y la DM y no hay control de la enfermedad. Este trabajo aporta al diseño de políticas públicas de prevención del daño a la salud por el consumo excesivo de BGA y su relación con la DM. De igual manera aquellas políticas públicas que rescaten y fomenten las buenas prácticas nutritivas entre las comunidades de los pueblos originarios.

Abstract Purpose: To analyze diabetes mellitus (DM) in a multifactorial manner with the consumption of sugar-sweetened beverages (SSB) and variables like nutritional status, sex, genetic predisposition, age and ethnicity; in order to determine the relationship between BGA and DM in the Mazahua Otomí (MO) community. Methodological design: This quantitative survey on social and nutritional variables was designed, validated and applied. A logistic model was developed to find the relationship of DM in relation to the variables: SSB consumption, sex, genetic predisposition, age, body mass index and ethnicity. Results: The Mazahua otomi community has a monthly family income below the extreme poverty line; they do not have disease control: 68% are obese or overweight and SSB consumption is medium to high in 90% of the population. In a multifactorial manner and according to the model, there is a probability of manifesting DM depending on the variables mentioned above; while, with the exception of nutritional status and age, the others are the most significant. In taste and preferences, 52% opt for the Coca-Cola SSB brand. Research limitations: The results found should be complemented in other case studies in communities with similar characteristics and a broader probabilistic population sample. Finding: In the MO community there is a relationship between BGA consumption and DM and there is no control of the disease. This work contributes to the design of public policies to prevent health damage because of excessive consumption of SSB and its relationship with DM; likewise, those policies that rescue and promote good nutritional practices of the communities of indigenous peoples.

Resumen Objetivo: Analizar en forma multifactorial la diabetes mellitus (DM) con el consumo de las bebidas gaseosas azucaradas (BGA) y de las variables estado nutricional, sexo, predisposición genética, edad y etnia, para determinar la relación de las BGA y la DM en la comunidad Mazahua Otomí (MO). Diseño Metodológico: El estudio fue cuantitativo. Se diseñó, validó y aplicó una encuesta estructurada sobre variables sociales y nutricionales. Se elaboró un modelo logístico para encontrar la relación de DM con las variables: consumo de BGA, sexo, predisposición genética, edad, índice de masa corporal y etnia. Resultados: En la comunidad MO que se investigó un padre de familia promedio tiene un ingreso mensual por debajo de la línea de pobreza extrema y no existe control de la enfermedad de estudio: 68% tiene obesidad o sobrepeso y el consumo de BGA es entre medio y alto en 90% de la población. En forma multifactorial, hay probabilidad de manifestar la DM en función de las variables antes señaladas; mientras que, a excepción de estado nutricional y la edad, las demás son las más significativas. En gustos y preferencias, 52% opta por la marca de BGA Coca-Cola. Limitaciones de la investigación: Los resultados encontrados deberán complementarse con estudios de caso en comunidades con características similares y una muestra poblacional probabilística más amplia. Hallazgos: En la comunidad MO existe una relación entre el consumo de BGA y la DM y no hay control de la enfermedad. Este trabajo aporta al diseño de políticas públicas de prevención del daño a la salud por el consumo excesivo de BGA y su relación con la DM. De igual manera aquellas políticas públicas que rescaten y fomenten las buenas prácticas nutritivas entre las comunidades de los pueblos originarios.

Abstract: Coseriu’s three-dimensional conception of varieties does not take into account all the existing varieties: some do not fit into the established categories and the status of others is diffuse; given the multifactorial nature of the varieties, the diffusion can be attributed to several dimensions. His conception ignores the dynamic character of the social status ot the varieties in the course of evolution. This paper offers a deconstructivist analysis of essential points in Koch and Oesterreicher’s “variational chain”, a theory that postulates a fixed orientation between the varieties of the diasystem. Cristicism is levelled at the mechanical character of its conception and at the rigidity of its orientation. A different vision (inspired by the energeia of Humboldt, including the role of the speaker) is proposed that considers varieties as a device that must be analyzed as a contact between varieties.

Resumen: La concepción tridimensional de variedades de Coseriu no considera todas las variedades de lengua que existen; además, algunas no caben en las categorías establecidas y el estatus de otras es difuso, lo que -por su carácter multifactorial- puede atribuirse a varias dimensiones. Tal concepción ignora el carácter dinámico de su naturaleza social a lo largo de la evolución. Mediante un análisis deconstruccionista, en este trabajo se cuestionan puntos esenciales de la “cadena variacional” (Koch y Oesterreicher) que postula una orientación fija entre las variedades del diasistema; se critica el carácter mecánico de esta concepción y la rigidez de la orientación; por último, se propone otra visión (inspirada en la energeia de Humboldt, incluido el papel del hablante) que considera las variedades un dispositivo que debe analizarse como contacto entre variedades.

Resumo Introdução: A deficiência de crescimento na doença renal crônica está relacionada à elevada morbidade e mortalidade. O retardo do crescimento nessa doença é multifatorial. É fundamental conhecer os fatores modificáveis e estabelecer estratégias para melhorar o atendimento às crianças afetadas. Objetivos: Descrever padrões de crescimento em crianças com DRC e fatores de risco associados à baixa estatura. Métodos: Analisamos retrospectivamente dados antropométricos e epidemiológicos, peso ao nascer, prematuridade e níveis de bicarbonato, hemoglobina, cálcio, fosfato, fosfatase alcalina e paratormônio de crianças com DRC estágios 3–5, não submetidas a diálise, acompanhadas por pelo menos um ano. Resultados: Incluímos 43 crianças, a maioria meninos (65%). O escore z médio de altura/comprimento/idade das crianças no início e no acompanhamento foi de –1,89 ± 1,84 e –2,4 ± 1,67, respectivamente (p = 0,011). Cinquenta e um por cento das crianças apresentaram baixa estatura, e essas crianças eram mais jovens que aquelas com estatura adequada (p = 0,027). Níveis de PTH no início do acompanhamento correlacionados com escore z de altura/comprimento/idade. Uma subanálise com crianças menores de cinco anos (n = 17) mostrou que 10 (58,8%) delas apresentaram déficit de desenvolvimento e escore z de peso/idade mais baixo (0,031) e escore z de IMC/idade mais baixo (p = 0,047). Conclusão: Crianças, especialmente mais jovens, com DRC, que não estavam em diálise, apresentaram elevada prevalência de baixa estatura. Níveis de PTH foram correlacionados com escore z de altura, e deficiência de crescimento foi associada a pior estado nutricional. Portanto, é essencial monitorar o crescimento dessas crianças, controlar o hiperparatireoidismo e fornecer suporte nutricional. Introdução mortalidade multifatorial afetadas Objetivos Métodos epidemiológicos nascer bicarbonato hemoglobina cálcio fosfato 35 3 5 3–5 diálise ano Resultados 4 65%. 65 65% . (65%) alturacomprimentoidade altura comprimento idade 189 1 89 –1,8 184 84 1,8 24 2 –2, 167 67 1,67 p 0,011. 0011 0,011 0 011 0,011) 0,027. 0027 0,027 027 0,027) n 17 58,8% 588 58 8 (58,8% pesoidade 0,031 0031 031 (0,031 IMCidade IMC 0,047. 0047 0,047 047 0,047) Conclusão Crianças nutricional Portanto 3– 6 (65% 18 –1, 1, –2 16 1,6 001 0,01 01 002 0,02 02 58,8 (58,8 0,03 003 03 (0,03 004 0,04 04 (65 –1 – 00 0,0 58, (58, (0,0 (6 0, (58 (0, ( (5 (0

Abstract Introduction: Growth failure in chronic kidney disease is related to high morbidity and mortality. Growth retardation in this disease is multifactorial. Knowing the modifiable factors and establishing strategies to improve care for affected children is paramount. Objectives: To describe growth patterns in children with chronic kidney disease and the risk factors associated with short stature. Methods: We retrospectively analyzed anthropometric and epidemiological data, birth weight, prematurity, and bicarbonate, hemoglobin, calcium, phosphate, alkaline phosphatase, and parathormone levels of children with stages 3–5 CKD not on dialysis, followed for at least one year. Results: We included 43 children, the majority of which were boys (65%). The mean height/length /age z-score of the children at the beginning and follow-up was –1.89 ± 1.84 and –2.4 ± 1.67, respectively (p = 0.011). Fifty-one percent of the children had short stature, and these children were younger than those with adequate stature (p = 0.027). PTH levels at the beginning of the follow-up correlated with height/length/age z-score. A sub-analysis with children under five (n = 17) showed that 10 (58.8%) of them failed to thrive and had a lower weight/age z-score (0.031) and lower BMI/age z-score (p = 0.047). Conclusion: Children, particularly younger ones, with chronic kidney disease who were not on dialysis had a high prevalence of short stature. PTH levels were correlated with height z-score, and growth failure was associated with worse nutritional status. Therefore, it is essential to monitor the growth of these children, control hyperparathyroidism, and provide nutritional support. Introduction mortality multifactorial paramount Objectives Methods data weight prematurity bicarbonate hemoglobin calcium phosphate phosphatase 35 3 5 3– year Results 4 65%. 65 65% . (65%) heightlength length age zscore z score followup follow up 189 1 89 –1.8 184 84 1.8 24 2 –2. 167 67 1.67 p 0.011. 0011 0.011 0 011 0.011) Fiftyone Fifty 0.027. 0027 0.027 027 0.027) heightlengthage zscore. score. subanalysis sub analysis n 17 58.8% 588 58 8 (58.8% weightage 0.031 0031 031 (0.031 BMIage BMI 0.047. 0047 0.047 047 0.047) Conclusion Children ones zscore, score, status Therefore hyperparathyroidism support 6 (65% 18 –1. 1. –2 16 1.6 001 0.01 01 002 0.02 02 58.8 (58.8 0.03 003 03 (0.03 004 0.04 04 (65 –1 – 00 0.0 58. (58. (0.0 (6 0. (58 (0. ( (5 (0

Resumo: Introdução: A hipertensão arterial (HA) é a principal causa de morte por doenças cardiovasculares. Apesar dos avanços, o percentual de hipertensos não diagnosticados e não tratados é de 58,4%. A avaliação do dano cognitivo na hipertensão concentra-se na prevenção do acidente vascular cerebral, enquanto o dano funcional é ignorado. Esse manejo inadequado pode ser multifatorial. É objetivo fue analisar a opinião dos médicos sobre a relação entre hipertensão arterial e danos cognitivos. Metodologia: Estudo observacional, descritivo, transversal desenvolvido no período entre agosto de 2020 e agosto de 2023. Análise de dados obtidos a partir de questionário autoaplicável, anônimo e voluntário. Revelar informações sobre o perfil profissional, conhecimento sobre a HA, sua ligação com o comprometimento cognitivo (DC), diagnóstico e tratamento. Resultados: Foram incluídos 222 profissionais, 215 (96,8%) concordam com a existência de ligação entre hipertensão e outros fatores de risco cardiovascular na DC e 218 (98,1%) reconhecem ajudar pacientes com risco de sofrer de D.C. A avaliação da DC é realizada em casos selecionados por 132 (59,4%) participantes e 59 (26,7%) a fazem sempre. Dos que realizam avaliação, 103 (54%) utilizam o Mini Exame do Estado Mental (MEEM), 10 (5,2%) utilizam a Avaliação Cognitiva de Montreal (MoCA) e 9 (4,7%) utilizam o Clock Drawing Test. Em relação à diminuição da pressão arterial em pacientes idosos e a ligação com o risco de DC: 54 (24,3%) não reconhecem risco e 65 (29,2%) reconhecem risco moderado-alto. Em referência à implicação do tratamento de doenças cardiovasculares e DC: 217 (97,7%) reconheceram o efeito benéfico. Discussão: Dado o reconhecimento da ligação entre hipertensão e DC, seria de esperar que a DC fosse investigada na grande maioria, no entanto apenas 26,7% sempre a avaliam. Não há consenso sobre o método, sendo o MEEM o mais utilizado, com baixa aplicação do teste MoCA e/ou Clock Drawing Test, sendo estes últimos os que avaliam a função executiva, majoritariamente alterada nos DC vinculados à HA. Embora o tratamento das doenças cardiovasculares seja reconhecido como benéfico em relação à DC, o controle da HA em idosos é considerado arriscado. É feito um diagnóstico de uma situação em que é evidente uma disparidade entre o que se reconhece como saber e o que se afirma fazer. Conclusões: O papel da doença vascular no dano cerebral funcional é reconhecido, considerando-se necessário conhecer o estado cognitivo dos pacientes, porém há baixa aplicação de testes de triagem que avaliam a função executiva. Nesse contexto, evidencia-se uma lacuna entre o conhecimento e a prática médica.

Abstract: Introduction: High blood pressure (HBP) is the leading cause of death from cardiovascular disease. Despite the advances, the percentage of undiagnosed and untreated hypertensive patients is 58.4%. The evaluation of cognitive damage in HBP focuses on preventing stroke, while functional damage is ignored. This inadequate management may be multifactorial. The objective was to analyze the opinions that doctors have about the relationship between high blood pressure and cognitive damage. Methodology: Observational, descriptive, cross-sectional study developed in the period between August 2020 and August 2023. Analysis of data obtained from a self-administered, anonymous and voluntary questionnaire. Revealing information on the professional profile, knowledge of HBP, its link with cognitive impairment (CD), diagnosis and treatment. Results: 222 professionals were included, 215 (96.8%) agree with the existence of a link between HBP and other cardiovascular risk factors in CD, and 218 (98.1%) acknowledge assisting patients at risk of suffering from CD. The CD evaluation is carried out in selected cases by 132 (59.4%) participants and 59 (26.7%) always do it. Of those who perform evaluation, 103 (54%) use the Mini Mental State Examination (MMSE), 10 (5.2%) use the Montreal Cognitive Assessment (MoCA) and 9 (4.7%) use the Clock Drawing Test. Regarding the decrease in blood pressure in elderly patients and the link with risk of CD: 54 (24.3%) do not recognize risk and 65 (29.2%) recognize a moderate-high risk. In reference to the implication of the treatment of cardiovascular disease and CD: 217 (97.7%) recognized a beneficial effect. Discussion: Given the recognition of the link between HBP and CD, it would be expected that CD would be investigated in the vast majority, however only 26.7% always evaluate it. There is no consensus on the method, the MMSE being the most used, with a low application of the MoCA test and/or Clock Drawing Test, the latter being the ones that evaluate executive function, mostly altered in CD linked to HBP. Although the treatment of cardiovascular disease is recognized as beneficial with respect to CD, the control of HBP in older adults is considered risky. A diagnosis is made of a situation where a disparity is evident between what one recognizes as knowing and what one claims to do. Conclusions: The role of vascular disease in functional brain damage is recognized, considering it necessary to know the cognitive status of patients, however there is a low application of screening tests that evaluate executive function. In this context, a gap between medical knowledge and practice is shown.

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Resumo: A compreensão dos princípios de inclusão e diversidade é um processo dialógico e recursivo que os sujeitos constroem e reconstroem ao longo de suas trajetórias de vida. Os dissensos críticos sobre inclusão são entendidos a partir das relações de alteridade, vista como um processo interpelativo. Por sua vez, a diversidade é entendida como um processo de reconhecimento das diferenças e diversidades dos sujeitos. O objetivo da pesquisa é desvendar a configuração de significado em relação à inclusão e à diversidade a partir dos discursos ativos do corpo acadêmico que forma educadores com base nas experiências vividas. A pesquisa foi enquadrada em um paradigma interpretativo de natureza qualitativa, com um delineamento fenomenológico hermenêutico. Foi utilizada uma amostra de conveniência de dez participantes e foram realizadas entrevistas semiestruturadas. Os participantes configuram o significado de inclusão e diversidade como um espaço multifatorial para a expressão da singularidade, no qual o corpo acadêmico e os estudantes podem expressar sua diversidade como elemento enriquecedor do processo educacional. Isso ocorre por meio da construção de experiências formativas que respondem a um desenho universal de ensino e aprendizagem

Resumen: La comprensión de los principios de inclusión y diversidad es un proceso dialógico y recursivo que los sujetos construyen y reconstruyen a lo largo de su trayectoria de vida. Los disensos críticos de inclusión la comprenden desde las relaciones de alteridad, mirada como un proceso interpelativo. A su vez, la diversidad es comprendida como un proceso de reconocimiento de las diferencias y diversidades de los sujetos. El objetivo de la investigación es develar la configuración de significado respecto a la inclusión y diversidad desde los discursos activos del cuerpo académico que forma educadores desde las experiencias vividas. La investigación se enmarcó en un paradigma interpretativo de naturaleza cualitativa, con un diseño fenomenológico hermenéutico. Se utilizó una muestra por conveniencia de diez participantes a los que se les realizó una entrevista semiestructurada. Los participantes configuran el significado de inclusión y diversidad como un espacio multifactorial para la expresión de la singularidad, en la que el cuerpo académico y el estudiantado pueden expresar su diversidad como elemento enriquecedor del proceso educativo. Esto se produce por la construcción de experiencias formativas que responden a un diseño universal de la enseñanza y del aprendizaje

Abstract: The understanding of the principles of inclusion and diversity is a dialogic and recursive process that individuals construct and reconstruct throughout their life journey. Critical perspectives on inclusion view it through the lens of otherness, seeing it as an interpellative process. Similarly, diversity is understood as the recognition of differences and diversities among individuals. The aim of this research is to uncover how the meaning of inclusion and diversity is configured through the active discourses of higher education faculty who train educators, drawing from their lived experiences. The study is framed within an interpretive, qualitative paradigm, using a hermeneutic-phenomenological design. A convenience sample of ten participants was selected, each of whom participated in a semi-structured interview. The participants define inclusion and diversity as a multifactorial space for the expression of individuality, where both faculty and students can express their diversity as an enriching element of the educational process. This occurs through the creation of formative experiences that align with a universal design for teaching and learning

BACKGROUND. Adverse events are common, and impact patients and healthcare systems negatively. Large international systems investigate adverse events at length, but South African data are lacking. OBJECTIVES. To classify all adverse events that have occurred in our department over the last decade. METHODS. Ten years of data from a prospectively collated electronic medical record system were analysed for adverse events. All admitted patients were included. Duplicate entries and those that did not describe adverse events were excluded. RESULTS. The study period was from December 2012 to January 2023. There were 52 835 distinct admissions covering 321 385 inpatient days. After categorisation, a total of 14 537 adverse events were captured, giving an adverse event rate of 22%. Adverse events were categorised into four groups. Of the total, 8 027 events were clinical care related, 3 106 were pathology related, 2 662 were system related and 442 miscellaneous. A total of 300 were excluded. Clinical care-related adverse events comprised 57.3% of the total number. Of those, adverse events related to indwelling devices (32.4%), iatrogenic injuries (12.5%) and intravenous therapy administration (12.5%) contributed most. Pathology-related adverse events contributed 21.4% of the total, of which wound sepsis (29.5%), anastomotic leak (15.1%) and nosocomial pneumonia (14.4%) were the most common. There was a general downward trend in reported adverse events from 2016 to 2022. CONCLUSION. Adverse events are common, and their aetiology is multifactorial. A sustained and multi-faceted approach is needed to address the challenge they pose.

BACKGROUND: Academic exclusion is practised in many national and international higher education institutions (HEIs), significantly impacting students' futures. Associated stress and anxiety remain a source of conflict between all role players. Reasons for, and the rationale behind, academic exclusion are complex and multifactorial OBJECTIVES: To investigate and describe contemporary practices and core themes relating to academic exclusion by reviewing the academic policies and procedures in a sample of six South African HEIs within a health professions education context METHODS: A prospective, pragmatic design was followed. This involved simple content analysis of source documents to identify similarities and differences in approach to academic exclusion, including the rationale and potential implications thereof RESULTS: The rationale for exclusion remains multifactorial. The majority of institutions linked exclusion to continued poor performance and failure to complete qualifications within the maximum time. All institutions allowed for an appeal process; however, this differed significantly between institutions CONCLUSION: There is a clear, defendable rationale for the exclusion, and practices that seek to prevent students from continuing should be guided by policies and procedures that are clear and contextually relevant. While the right to appeal exclusion is supported, arbitrary support for such appeals in the absence of merit defeats the aims, objectives and rationale for exclusion

Abstract Context: Female Sexual Dysfunctions (FSD) are prevalent conditions, can occur in any stage of life and can severely affect women’s quality of life. The etiology of FSD is often multifactorial, including biologic, psychological, interpersonal and sociocultural factors. Objectives: To evaluate FSD in a Portuguese population and what factors can influence the female sexual function. Methods: A cross-sectional study was conducted between August and September of 2023. Participants filled an anonymous online survey, including a demographic questionnaire and the Female Sexual Function Index (FSFI) for evaluation of sexual function. Inclusion criteria: age between 18 and 75 years old, residence in Portugal and being in a heterosexual relationship. The total score FSFI and domain scores (desire, arousal, lubrification, orgasm, satisfaction and discomfort) were analyzed using SPSS 22®. Results: A total of 401 women completed the questionnaire, 393 fulfilled the inclusion criteria. Women had a mean age of 41,6 years (range: 20-71 years). From these, 48% of women reported being moderately satisfied or very satisfied with their sex life and 9,6% reported no sexual intercourse in the past 4 weeks. Among sexually active women, the mean total FSFI score was 27.37 (range: 7.5-34.5±4.99) and 36% met the criteria for sexual dysfunction (FSFI score ≤ 26.55). Post-menopausal participants, when compared to women in reproductive age, had a lower mean total score and also had lower mean scores across all domains, except for discomfort (p<0.05). Women with children or a BMI ≥ 25 had lower mean total score and lower mean scores for desire, arousal and satisfaction domains (p<0.05). Conclusions: The prevalence of FSD was 36%. These findings highlight the importance of addressing FSD as a significant concern for women health and quality of life and the need for training and awareness among healthcare professionals.

Resumo Introdução: As disfunções sexuais femininas (DSF) são condições prevalentes. Estas podem ocorrer em qualquer fase da vida e podem afetar negativamente a qualidade de vida de muitas mulheres. A etiologia das DSF é frequentemente multifatorial, incluindo fatores biológicos, psicológicos, interpessoais e socioculturais. Objetivos: Avaliar as DSF em mulheres portuguesas e identificar possíveis fatores que possam influenciar a sexualidade feminina. Métodos: Estudo transversal observacional realizado entre agosto e setembro de 2023, através do preenchimento de questionário online anónimo, que incluía um questionário demográfico e o Female Sexual Function Index (FSFI) para avaliação da resposta sexual. A pontuação total e dos domínios (desejo, excitação, lubrificação, orgasmo, satisfação e desconforto) foram analisados utilizando o SPSS 22®. Resultados: De um total de 401 mulheres que completaram o questionário, 393 preenchiam os critérios de inclusão no estudo. A idade média das inquiridas foi de 41,6 anos (20-71 anos). Quando questionadas, 74% das mulheres referiram estar moderadamente satisfeitas ou muito satisfeitas com a sua vida sexual e 9,6% das mulheres referiu ausência de relações sexuais nas últimas quatro semanas. Entre as mulheres sexualmente ativas, a pontuação média total do FSFI foi de 27,37 (7,5-34,5±4,99) e 36% preenchiam os critérios para disfunção sexual (Pontuação FSFI ≤ 26,55). As participantes na pós-menopausa, em comparação com as mulheres em idade reprodutiva, apresentaram uma pontuação média total inferior, assim como pontuações médias inferiores em todos os domínios, exceto no desconforto (p<0,05). Mulheres com filhos ou com IMC ≥25 tiveram uma pontuação média total e pontuações médias inferiores nos domínios do desejo, excitação e satisfação (p<0,05). Conclusões: A prevalência de problemas sexuais na população em estudo foi de 36%. Estes achados destacam a importância de abordar as DSF como uma preocupação na saúde e qualidade de vida das mulheres e da necessidade de formação e sensibilização dos profissionais de saúde.

Resumen Este artículo analiza el problema del aumento de la violencia en Ecuador durante los últimos años. Para ello, se presenta el tema a través de dos ejes. En primer lugar, se ofrece una aproximación general a la violencia desde la perspectiva transnacional y global del crimen organizado. Se debate la estructura general de las economías ilícitas y se propone varias explicaciones a la dinámica de la violencia, que relaciona los problemas globales con los locales. En segundo lugar, se presentan datos de la situación de la violencia en el país, y se discute la evolución en los diferentes escenarios que se suscitan en cada región. Se muestran estadísticos descriptivos y además se propone, de forma exploratoria, un modelo que vincula diferentes variables de la estructura socioeconómica interna de los cantones del país para relacionarlos con la violencia. Por último, se hace un repaso de la situación general de las cárceles en el país.

Abstract This paper seeks a multifactorial explanation to the problem of the increase in violence in Ecuador in recent years. To this end, the topic is presented along two axes. First, it offers a general approach to violence from the transnational and global perspective of organized crime. The general structure of illicit economies is discussed and several explanations for the dynamics of violence are proposed, linking global and local problems. Secondly, data about violence in the country is presented, and the evolution of the different scenarios that arise in each region is discussed. Descriptive statistics are shown, and a model is also proposed, in an exploratory manner, that links different variables of the socioeconomic structure of the country's cantons to relate them to violence. Finally, a review is made of the general situation of prisons in the country.

ABSTRACT Introduction: Although the cause of childhood obesity is multifactorial, it is known that breastfeeding (BF) could be a protective element. Objective: To determine the association of obesity in children with the duration of BF, parental educational levels and types of employment and family formation in a group of children from Encarnación, Paraguay. Methodology: This was a longitudinal, retrospective and descriptive study with an analytical component carried out in 200 children of both sexes. Nutritional status was evaluated at 2, 4 and 6 years, duration of BF. Families were grouped according to parental education levels and types of employment (Group A: up to 6th grade of Elementary Education [EE] and informal economy work; Group B: up to 12th grade of EE and public/commercial employment; Group C: tertiary education and managerial employment positions or business ownership. A value of p <0.05 was considered significant. Results: 50% (n=100) were men, 96.5% (n=193) from urban areas, 70% (n=140) came from nuclear families, 73% (n=146) were families from group B. BF duration was ≤4 months 5.5% (n=11), up to 6 months 9% (n=18), 7 to 11 months 20.5% (n=41), continued BF (≥1 year) 63 .5%(n=127). 14.5%, 18% and 18.5% were obese at 2, 4 and 6 years respectively. There was greater obesity at 4 years with BF <6 months (42.9% vs 16.1% Chi2 p=0.02), but not at 2 or 6 years. No significant association of obesity with parental employment or educational level or with the presence of a partner (Chi2 p≥0.05). Conclusion: Breastfeeding duration of less than 6 months is associated with a higher frequency of obesity at 4 years of age.

RESUMEN Introducción: Aunque la causa de la obesidad infantil es multifactorial, se sabe que la lactancia materna (LM) podría ser un elemento protector. Objetivo: Determinar la asociación de obesidad en los niños con la duración de la LM, escolaridad y tipo de empleo de padres y conformación familiar en un grupo de niños de Encarnación-Paraguay. Metodología: estudio longitudinal, retrospectivo y descriptivo con componente analítico realizado con 200 niños de ambos sexos. Se evaluó estado nutricional a los 2, 4 y 6 años, duración de LM, agrupación familiar según nivel de escolaridad y tipo de empleo (Grupo A: hasta 6° grado de la Educación Escolar Básica (EEB) y trabajo informa; 2)Grupo B: hasta 3° de EEB y empleados públicos/comerciales; 3)Grupo C: educación terciaria y cargos jerárquicos o dueños de corporaciones.Se consideró valor de p<0,05 como significativo. Resultados: 50%(n=100) fueron varones, 96,5%(n=193) del área urbana, 70%(n=140) con familia nuclear, 73%(n=146) fueron familias del grupo B. Tuvo LM ≤4 meses el 5,5%(n=11), hasta 6 meses 9%(n=18), 7 a 11 meses el 20,5%(n=41), LM continuada (≥1 año) el 63,5%(n=127). Presentaron obesidad el 14,5%, 18% y 18,5% a los 2, 4 y 6 años respectivamente. Hubo mayor obesidad a los 4 años con LM <6 meses (42,9% vs 16,1% Chi2 p=0,02), no así a los 2 o 6 años. Sin asociación significativa de obesidad con tipo de empleo y escolaridad de los padres o con presencia de pareja (Chi2 p≥0,05). Conclusión: La duración de lactancia materna menor a 6 meses se asocia con mayor frecuencia de obesidad a los 4 años.

RESUMEN El desarrollo profesional en la escuela básica, como evidencia del nivel de desempeño profesional pedagógico, es objeto de atención en contextos nacionales y locales centrados en la elevación de la calidad educativa al considerar las exigencias de la Agenda 2030. Resulta necesario que el docente asuma el reto fijado desde la concreción de los objetivos en cada sistema nacional de educación en su derivación para la escuela básica. Desde una perspectiva dialéctico-materialista se utilizan los métodos: análisis documental, encuesta, entrevista y se aplica la triangulación metodológica para favorecer el desempeño profesional pedagógico observable en el sistema de relaciones de la institución, educandos y familias en el tránsito hacia el desarrollo profesional que se aspira proponer un resultado científico que desde las acciones de preparación. En tal sentido, el artículo socializa los elementos relativos al proceso de profesionalización que propician el desarrollo profesional desde el desempeño profesional pedagógico en la escuela básica a partir de elementos generales y contextuales que previo diagnóstico inicial, ofrecen la base para proponer una estrategia pedagógica. Como resultado se establecen los elementos multifactoriales que influyen en el desarrollo profesional a partir de la estrategia pedagógica postgraduada potencia desempeños exitosos en las funciones de instruir y educar.

ABSTRACT Professional development in basic school, as evidence of the level of professional pedagogical performance, is the object of attention in national and local contexts focused on raising educational quality when considering the demands of the 2030 Agenda. It is necessary for the teacher to assume the challenge set from the realization of the objectives in each national education system in its derivation to basic school. From a dialectical-materialist perspective, the methods are used: documentary analysis, survey, interview and methodological triangulation is applied to promote professional pedagogical performance observable in the system of relationships of the institution, students and families in the transition towards professional development that. The aim is to propose a scientific result from the preparatory actions. In this sense, the article socializes the elements related to the professionalization process that promote professional development from professional pedagogical performance in basic school based on general and contextual elements that, after an initial diagnosis, offer the basis for proposing a pedagogical strategy. As a result, the multifactorial elements that influence professional development are established based on the postgraduate pedagogical strategy that enhances successful performances in the functions of instructing and educating.

RESUMEN Aprender constituye uno de los mayores desafíos que enfrenta el sujeto. Un suceso biológico, psicológico y social multifactorial que implica: las potencialidades del sujeto, la motivación para aprender, la calidad de los servicios educacionales, la psicomotricidad y las capacidades cognitivas. Las limitaciones en estas últimas, caracterizan a los educandos con dificultades en el aprendizaje y demandan la búsqueda de recursos atemperados a los adelantos de la ciencia y a las particularidades del sujeto. A partir de la indagación teórica, es objetivo presentar un cuaderno de actividades basado en la expresión corporal para contribuir a potenciar las capacidades cognitivas básicas para aprender de los educandos de segundo grado con esta desviación del desarrollo intelectual, desde lo más natural y propio; aquello que para ellos es potencialidad: el movimiento. Se utilizaron métodos del nivel teórico, empírico y matemáticos. La propuesta se orienta al trabajo correctivo compensatorio que realiza la institución educativa de la Educación Especial: Batalla de Ogaden para educandos con Retardo en el desarrollo psíquico del municipio San Miguel del Padrón. Su instrumentación es factible en cualquier espacio del proceso pedagógico y el entorno familiar; además de contextualizarse a otros grados y situaciones de aprendizaje, previa preparación del docente.

ABSTRACT Learning constitutes one of the greatest challenges faced by the subject. It is a multifactorial biological, psychological and social event that involves: the subject's potential, motivation to learn, the quality of educational services, psychomotor skills and cognitive abilities. The limitations in the latter characterize students with learning difficulties and demand the search for resources adjusted to the advances of science and the particularities of the subject. From the theoretical inquiry, the objective is to present a notebook of activities based on corporal expression to contribute to enhance the basic cognitive capacities to learn of second grade students with this deviation of intellectual development, from what is most natural and proper; that which for them is potentiality: movement. Theoretical, empirical and mathematical methods were used. The proposal is oriented to the compensatory corrective work carried out by the educational institution of Special Education: Batalla de Ogaden for students with retarded mental development in the municipality of San Miguel del Padrón. Its instrumentation is feasible in any space of the pedagogical process and the family environment; it can also be contextualized to other grades and learning situations, prior preparation of the teacher.

Resumen La neumatosis intestinal y el neumoperitoneo no son entidades patológicas en sí mismas, son signos radio lógicos que resultan de alguna condición subyacente. En general, estos se asocian con procesos graves intra-abdominales que resultan en cirugías de urgencias con resecciones de intestino. A continuación, presentamos el caso de una mujer de 80 años, con diagnóstico de cáncer de mama estadio IV en tratamiento con ful vestrant y ribociclib, que ingresó a nuestro centro por dolor abdominal y vómitos. Se diagnosticó neumatosis intestinal y neumoperitoneo por lo que se procedió a laparotomía exploradora por sospecha de isquemia intestinal. No hubo evidencia de necrosis o perforación intestinal por lo que no se realizó resección. Evolucionó durante la internación de forma satisfactoria y en el control tomográfico al mes del egreso hubo resolución completa del cuadro. Si bien está descrito esta afectación en relación a los episodios de aumento de presión intraabdominal, como en la emesis, también se describió en pacientes con neoplasias, principalmente del tubo digestivo, ya sea por daño local o por toxicidad asociada a la quimioterapia. No encontramos reportes en la literatura de neumatosis intestinal vinculada a esta medicación antineoplásica en humanos. Probablemente en nuestro caso la etiolo gía haya sido multifactorial. Es posible que el ribociclib haya jugado un rol, ya sea por un mecanismo indirecto asociado a los vómitos y la inmunosupresión o directo sobre el enterocito debido a su mecanismo de acción celular no específico.

Abstract Pneumatosis intestinalis and pneumoperitoneum are not pathological entities in themselves, they are radiological signs that result from some underlying condition. In general, these are associated with serious intra-abdominal processes that result in emergency surgeries with bowel resections. Below, we present the case of an 80-year-old woman, diagnosed with stage IV breast cancer under treatment with fulvestrant and ribociclib, who was admitted to our center due to abdominal pain and vomiting. She was diagnosed with intestinal pneumatosis and pneumoperitoneum, so she underwent exploratory laparotomy for sus pected intestinal ischemia. There was no evidence of intestinal necrosis or perforation, so resection was not performed. She progressed satisfactorily during hospitalization and in the tomographic control one month after discharge there was complete resolution of the condition. Although this condition has been described in relation to episodes of increased intra-abdominal pressure, such as emesis, it has also been described in patients with neoplasms, mainly of the digestive tract, either due to lo cal damage or toxicity associated with chemotherapy. We found no reports in the literature of pneumatosis intesti nalis linked to this antineoplastic medication in humans. Probably in our case the etiology was multifactorial. It is possible that ribociclib played a role, either through an indirect mechanism associated with vomiting and im munosuppression or directly on the enterocyte due to its non-specific cellular mechanism of action.