RESUMO Objetivo: Investigar os fatores contextuais associados à qualidade de vida (QV) de crianças brasileiras de zero a 12 anos, em momento de ápice de distanciamento social. Métodos: Estudo observacional, transversal, online, de julho a setembro de 2020, com questionário sobre fatores do contexto familiar associados à QV e Inventário Pediátrico sobre QV — PedsQL™. A análise dos dados foi feita por de regressão logística multinomial. Resultados: A amostra foi de 849 crianças, na maioria da Região Sul (75%), brancas (83%), com desenvolvimento típico (79%), sedentárias (68%), com uso de telas (85%) em tempo >3h/dia (44%). As mães eram as cuidadoras principais (90%). Foram significativamente associadas a escores mais elevados de QV: a condição de saúde típica (odds ratio — OR 2,38; intervalo de confiança de 95% — IC95% 1,60–3,55), o tempo de tela ≤2h/dia (OR 1,62; IC95% 1,17–2,24), o distanciamento social considerado “fácil” (OR 1,67; IC95% 1,20–2,32) e a família afirmar estimular a criança (OR 1,93; IC95% 1,08–3,45). Conclusões: Este estudo mostra que o contexto familiar pode influenciar a QV de crianças, especialmente no período de pandemia e de reorganização do ambiente domiciliar. Objetivo (QV 1 anos Métodos observacional transversal online 2020 PedsQL PedsQL™ multinomial Resultados 84 75%, 75 75% , (75%) 83%, 83 83% (83%) 79%, 79 79% (79%) 68%, 68 68% (68%) 85% 85 (85% 3hdia hdia 3h dia h 44%. 44 44% . (44%) 90%. 90 90% (90%) odds 2,38 238 2 38 95 IC95 IC 1,60–3,55, 160355 1,60–3,55 60 3 55 1,60–3,55) 2hdia 2h 1,62 162 62 1,17–2,24, 117224 1,17–2,24 17 24 1,17–2,24) fácil “fácil 1,67 167 67 1,20–2,32 120232 20 32 1,93 193 93 1,08–3,45. 108345 1,08–3,45 08 45 1,08–3,45) Conclusões domiciliar 202 8 7 (75% (83% (79% 6 (68% (85 4 (44% 9 (90% 2,3 23 IC9 16035 1,60–3,5 5 1,6 16 11722 1,17–2,2 1,20–2,3 12023 1,9 19 10834 1,08–3,4 0 (75 (83 (79 (68 (8 (44 (90 2, 1603 1,60–3, 1, 1172 1,17–2, 1,20–2, 1202 1083 1,08–3, (7 (6 ( (4 (9 160 1,60–3 117 1,17–2 1,20–2 120 108 1,08–3 1,60– 11 1,17– 1,20– 10 1,08– 1,60 1,17 1,20 1,08 1,1 1,2 1,0

ABSTRACT Objective: The aim of this study was to investigate the contextual factors associated with the quality of life (QOL) of Brazilian children aged 0–12 years during the strict period of social isolation. Methods: This observational cross-sectional study was conducted between July and September 2020 using an online questionnaire on QOL-related family factors and the Pediatric Quality of Life Inventory (PedsQL™). Results were analyzed by multinomial logistic regression analysis. Results: The sample had 849 children, mostly from the South Region of Brazil (75%), white (83%), with typical development (79%), sedentary (68%), using screen (85%) for >3 h/day (44%). Their mothers were their main caregivers (90%). The following variables were significantly associated with high scores of QOL: typical health status (OR 2.38; 95%CI 1.60–3.55; screen time ≤2 h/day (OR 1.62; 95%CI 1.17–2.24); social distancing considered as “easy” (OR 1.67; 95%CI 1.20–2.32), and stimulation of the child by the family (OR 1.93; 95%CI 1.08–3.45). Conclusions: This study indicates that the family context can influence children’s QOL, especially during the COVID-19 pandemic and home environment reorganization. Objective QOL (QOL 012 0 12 0–1 isolation Methods crosssectional cross sectional 202 QOLrelated related PedsQL™. PedsQL PedsQL™ . (PedsQL™) analysis 84 75%, 75 75% , (75%) 83%, 83 83% (83%) 79%, 79 79% (79%) 68%, 68 68% (68%) 85% 85 (85% 3 > hday h day 44%. 44 44% (44%) 90%. 90 90% (90%) OR 2.38 238 2 38 95CI CI 95 1.60–3.55 160355 1 60 55 ≤ 1.62 162 62 1.17–2.24 117224 17 24 1.17–2.24) easy “easy 1.67 167 67 1.20–2.32, 120232 1.20–2.32 20 32 1.20–2.32) 1.93 193 93 1.08–3.45. 108345 1.08–3.45 08 45 1.08–3.45) Conclusions childrens s COVID19 COVID 19 COVID-1 reorganization 01 0– (PedsQL™ 8 7 (75% (83% (79% 6 (68% (85 4 (44% 9 (90% 2.3 23 1.60–3.5 16035 5 1.6 16 1.17–2.2 11722 12023 1.20–2.3 1.9 10834 1.08–3.4 COVID1 COVID- (PedsQL (75 (83 (79 (68 (8 (44 (90 2. 1.60–3. 1603 1. 1.17–2. 1172 1202 1.20–2. 1083 1.08–3. (7 (6 ( (4 (9 1.60–3 160 1.17–2 117 120 1.20–2 108 1.08–3 1.60– 1.17– 11 1.20– 10 1.08– 1.60 1.17 1.20 1.08 1.1 1.2 1.0

ABSTRACT Purpose: To evaluate the predictive value of initial intraocular pressure difference of the detached and fellow eyes of patients with complex rhegmatogenous retinal detachment on postoperative persistent ocular hypotony. Methods: This retrospective observational study included 538 eyes of 538 unilateral complex rhegmatogenous retinal detachment patients with a proliferative vitreoretinopathy grade of C-1 or higher, treated with silicone oil endotamponade following pars plana vitrectomy. The patients were divided into Group A (patients having silicone oil removal without ocular hypotony; n=504) and Group B (patients with persistent ocular hypotony following silicone oil removal [n=8, 23.5%] and with retained silicone oil [n=26, 76.5%] due to the risk of persistent ocular hypotony; total n=34). Ocular hypotony was defined as an intraocular pressure of <6 mmHg on two or more occasions. Patients’ demographics, including age, sex, and follow-up time, and ocular characteristics, including ocular surgical and trauma history, initial and final best-corrected visual acuity, intraocular pressure and initial intraocular pressure difference of the detached and fellow eyes, and anatomical success rates and postoperative complications, were retrospectively collected from the electronic patient files. Results: The initial intraocular pressure was significantly lower in the detached eyes of Group B than in Group A (8.3 ± 3.5 vs. 12.9 ± 3.3, p<0.001). Also, the initial intraocular pressure difference was significantly higher in Group B than in Group A (8.9 ± 3.2 vs. 2.2 ± 2.7mmHg, p<0.001). The receiver operating characteristic curve analysis showed that the cutoff value of the initial intraocular pressure difference was 7.5mmHg for the risk of persistent ocular hypotony. The most influential factors on postoperative persistent ocular hypotony in the binary logistic regression analysis were the initial intraocular pressure difference and the need for a retinectomy. Conclusion: In eyes with complex rhegmatogenous retinal detachment treated with pars plana vitrectomy and silicone oil tamponade, the initial intraocular pressure difference could be of value in predicting postoperative persistent ocular hypotony and could guide surgeons on the decision of silicone oil removal. Purpose Methods 53 C1 C 1 C- n=504 n504 n 504 n=8, n8 8 [n=8 23.5% 235 23 5 n=26, n26 26 [n=26 76.5% 765 76 n=34. n34 n=34 . 34 n=34) 6 < occasions Patients demographics age sex followup follow up time characteristics history bestcorrected best corrected acuity complications files Results 8.3 83 3 (8. 35 3. vs 129 12 9 12. 33 3.3 p<0.001. p0001 p p<0.001 0 001 p<0.001) Also 8.9 89 32 2 22 2. 27mmHg 7mmHg 2.7mmHg 75mmHg 7 5mmHg retinectomy Conclusion tamponade n=50 n50 50 n=8 [n= 23.5 n=26 n2 [n=2 76.5 n3 n=3 8. (8 p000 p<0.00 00 n=5 n5 n= [n 23. n=2 76. ( p00 p<0.0 p0 p<0. p<0 p<

ABSTRACT Desertification is the degradation process caused by climatic conditions and human activities that results in loss of soil productivity and decline in vegetation growth in the long term. Several indices related to vegetation, soil and climate are used to monitor desertification, but few studies explore qualitative and quantitative aspects of indices on desertification on spatial and hierarchical scale. This study aims to identify and measure indices related to increased risk of desertification on global, local and hierarchical scales using multinomial logistic regression models. Images from TM, ETM+ and OLI sensor from 1997 to 2018 in the end of dry and rainy seasons were used to quantify NDVI, TGSI, albedo, temperature, aridity index, evapotranspiration and precipitation on global spatial scale (Irauçuba Centro Norte) and local spatial scale (Miraíma, Canindé, Irauçuba and Santa Quitéria). GISD was calculated by geometric mean of weighted indices and segmented into 8 classes of susceptibility to desertification (hierarchical scale). The results showed that the best models were obtained on local scale and for the end of the rainy season. Temperature proved to be the most important variable for increased risk of desertification on global, local and hierarchical scales. Therefore, the increase in the risk of desertification in the studied areas is due to human activities of deforestation, overgrazing and fire. These factors contributed to reduction of vegetation cover and increase in temperature, changing the microclimatic, which led to decline in precipitation and worsening of desertification. term TM ETM 199 201 NDVI TGSI albedo temperature index Norte Miraíma, Miraíma (Miraíma Canindé Quitéria. Quitéria . Quitéria) scale) season Therefore deforestation fire microclimatic 19 20 1 2

RESUMO Objetivo: Examinar a associação entre vitimização por bullying e comportamentos de risco à saúde em adolescentes. Métodos: Uma amostra representativa de 1.020 adolescentes participou do estudo. As variáveis bullying, comportamentos de risco à saúde (tabaco, drogas, álcool, comportamento sedentário, uso de smartphone, nível de atividade física, sono) e situação econômica foram avaliadas por meio de questionários autorreportados. Razões de chance com intervalos de confiança de 95% (IC95%) foram obtidas por meio de regressão logística binária e regressão logística ordinal, bruta e ajustada (p<0,05). Resultados: As vítimas de bullying apresentaram maior probabilidade de fumar (OR 1,75; IC95% 1,28–2,40), consumir álcool (OR 1,43; IC95% 1,05–1,94), ter pior qualidade de sono (OR 1,94; IC95% 1,28–2,91) e apresentar mais comportamento sedentário (OR 1,43; IC95% 1,08–1,89) do que aqueles que não sofreram bullying. No entanto, as vítimas eram mais propensas a ter níveis elevados de atividade física do que os seus pares não vítimas de bullying (OR 1,66; IC95% 1,22–2,27). Conclusões: A vitimização por bullying esteve associada ao aumento da predisposição para a adoção de comportamentos de risco à saúde. Curiosamente, as vítimas também eram mais propensas a participar de atividades físicas. Objetivo Métodos 1020 1 020 1.02 estudo tabaco, tabaco (tabaco drogas smartphone autorreportados 95 IC95 IC (IC95% ordinal p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Resultados OR 1,75 175 75 1,28–2,40, 128240 1,28–2,40 , 28 2 40 1,28–2,40) 1,43 143 43 1,05–1,94, 105194 1,05–1,94 94 1,05–1,94) 1,94 194 1,28–2,91 128291 91 1,08–1,89 108189 08 89 entanto 1,66 166 66 1,22–2,27. 122227 1,22–2,27 22 27 1,22–2,27) Conclusões Curiosamente físicas 102 02 1.0 9 IC9 (IC95 p00 p<0,0 (p<0,05 1,7 17 7 12824 1,28–2,4 4 1,4 14 10519 1,05–1,9 1,9 19 1,28–2,9 12829 1,08–1,8 10818 8 1,6 16 6 12222 1,22–2,2 10 1. (IC9 p0 p<0, (p<0,0 1, 1282 1,28–2, 1051 1,05–1, 1,08–1, 1081 1222 1,22–2, (IC p<0 (p<0, 128 1,28–2 105 1,05–1 1,08–1 108 122 1,22–2 p< (p<0 12 1,28– 1,05– 1,08– 1,22– (p< 1,28 1,05 1,08 1,22 (p 1,2 1,0

ABSTRACT Objective: The aim of this study was to examine the association between bullying victimization and health risk behaviors in adolescents. Methods: A representative sample of 1020 adolescents participated in the study. The variables such as bullying, health risk behaviors (tobacco, drugs, alcohol, sedentary behavior, smartphone use, level of physical activity, and sleep), and economic status were assessed using self-reported questionnaires. Odds ratios with 95% confidence intervals (95%CI) were obtained using binary logistic regression and ordinal, gross, and adjusted logistic regression (p<0.05). Results: Victims of bullying were more likely to smoke (OR 1.75; 95%CI 1.28–2.40), consume alcohol (OR1.43; 95%CI 1.05–1.94), have worse sleep quality (OR 1.94; 95%CI 1.28–2.91), and more sedentary behavior (OR 1.43; 95%CI 1.08–1.89) than those who were not bullied. However, victims were more likely to have high levels of physical activity than their non-bullied peers (OR 1.66; 95%CI 1.22–2.27). Conclusions: Bullying victimization was associated with an increased predisposition for the adoption of health risk behaviors. Interestingly, victims were also more prone to participate in physical activity. Objective Methods 102 tobacco, tobacco (tobacco drugs use sleep, , sleep) selfreported self reported questionnaires 95 95CI CI (95%CI ordinal gross p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Results OR 1.75 175 1 75 1.28–2.40, 128240 1.28–2.40 28 2 40 1.28–2.40) OR1.43 OR143 OR1 43 (OR1.43 1.05–1.94, 105194 1.05–1.94 94 1.05–1.94) 1.94 194 1.28–2.91, 128291 1.28–2.91 91 1.28–2.91) 1.43 143 1.08–1.89 108189 08 89 bullied However nonbullied non 1.66 166 66 1.22–2.27. 122227 1.22–2.27 22 27 1.22–2.27) Conclusions Interestingly 10 9 p00 p<0.0 (p<0.05 1.7 17 7 12824 1.28–2.4 4 OR1.4 OR14 (OR1.4 10519 1.05–1.9 1.9 19 12829 1.28–2.9 1.4 14 1.08–1.8 10818 8 1.6 16 6 12222 1.22–2.2 p0 p<0. (p<0.0 1. 1282 1.28–2. OR1. (OR1. 1051 1.05–1. 1.08–1. 1081 1222 1.22–2. p<0 (p<0. 128 1.28–2 (OR1 105 1.05–1 1.08–1 108 122 1.22–2 p< (p<0 12 1.28– 1.05– 1.08– 1.22– (p< 1.28 1.05 1.08 1.22 (p 1.2 1.0

RESUMEN Se entiende como calidad del trabajo intrínseco a variables como: el grado de autonomía, la variedad y complejidad de las tareas, el uso de habilidades y la posibilidad de desarrollo profesional en el trabajo. En tanto que, las perspectivas futuras abordan la percepción de los trabajadores sobre su futuro laboral, incluyendo aspectos como las oportunidades de progreso profesional, la seguridad en el empleo y la satisfacción laboral. La presente investigación tiene como objetivo analizar la importancia de las variables asociadas a la calidad intrínseca del trabajo y las perspectivas futuras en relación con el estrés experimentado por los trabajadores autónomos en Ecuador. Se aplicó un enfoque cuantitativo mediante regresión logística a datos de una muestra de 1055 trabajadores de la provincia de Manabí, utilizando la Encuesta Europea sobre Condiciones de Trabajo (EWCS) 2015. Se encontró que una evaluación positiva del trabajo propio está asociada con mayor estrés, mientras resolver problemas imprevistos personalmente se relaciona con menos estrés. Además, realizar tareas complejas y ofrecer formación pagada externa o en el lugar de trabajo aumenta la probabilidad de estrés. Por otro lado, menor satisfacción en el trabajo, disfrutar ser el propio jefe, dificultades para manejar el negocio, facilidad para encontrar nuevos clientes y la percepción de que el trabajo afecta la salud también están vinculados con mayor estrés. Estos hallazgos destacan la importancia de gestionar el trabajo y el entorno laboral para mejorar el bienestar de los trabajadores autónomos.

ABSTRACT Intrinsic job quality is understood in terms of variables such as: the degree of autonomy, the variety and complexity of tasks, the use of skills, and the possibility of professional development at work. Meanwhile, future prospects address workers' perceptions of their career future, including aspects such as opportunities for professional advancement, job security, and job satisfaction. This research aims to analyze the importance of variables associated with intrinsic job quality and future prospects in relation to the stress experienced by self-employed workers in Ecuador. A quantitative approach was applied using logistic regression to data from a sample of 1055 workers in the province of Manabí, utilizing the 2015 European Working Conditions Survey (EWCS). It was found that a positive assessment of one's own work is associated with higher stress, while personally resolving unforeseen problems is related to lower stress. Additionally, performing complex tasks and providing paid external or on-the-job training increases the likelihood of stress. On the other hand, lower job satisfaction, enjoying being one's own boss, difficulties in managing the business, ease in finding new clients, and the perception that work affects health are also linked to higher stress. These findings underscore the importance of managing work and the work environment to improve the well-being of self-employed workers.

Abstract Introduction: The COVID-19 pandemic has had an important impact on the training of nursing professionals, affecting the mental health of students due to the experiences they have faced. Objective: Assess the level of academic stress in nursing students and its relationship to anxiety, depression, insomnia, post-traumatic stress disorder, and experiences during the COVID-19 pandemic. Methodology: Correlational study with 1009 nursing students who agreed to participate. A virtual survey was applied, collecting sociodemographic and COVID-19 Pandemic experiences data, in addition to questionnaires on anxiety, depression, insomnia, and post-traumatic and academic stress, with prior authorization from the research and ethics committee. Statistical analysis such as Square Chi, Spearman's Rho and logistic regression model were used. Results: 68.1 % presented anxiety, 64.3 % depression, 56.3 % insomnia and 85.7 % academic stress. Academic stress showed statistical association with sex, school period, diagnosis in a family member and contact with a person suspected or confirmed of having COVID-19. Presenting academic stress is 3.9 times higher with moderate anxiety, 10.6 times higher with moderate depression, 12.7 times higher with moderate clinical insomnia, 1.8 times higher with a family member diagnosed with the disease, and 2.6 times higher with contact of suspected or confirmed COVID-19 cases. Conclusions: Mental health problems were related to academic stress levels in nursing students during the COVID-19 pandemic. The nursing professional must design educational and training strategies to reduce the levels of these problems, applicable from educational training to the workplace.

Abstrato Introdução: A Pandemia do COVID-19 teve um impacto significativo na formação dos profissionais de enfermagem, afetando a saúde mental dos estudantes devido às vivências por eles enfrentadas. Objetivo: Avaliar o nível de estresse acadêmico em estudantes de enfermagem e sua relação com ansiedade, depressão, insônia, transtorno de estresse pós-traumático e experiências durante a pandemia de COVID-19. Metodologia: Estudo correlacional com 1009 graduandos de enfermagem que concordaram em participar. Foi aplicada uma pesquisa virtual, coletando dados sociodemográficos e experiências da Pandemia da COVID-19, além de questionários sobre ansiedade, depressão, insônia e estresse pós-traumático e acadêmico, com autorização prévia do comitê de ética e pesquisa. Foram utilizadas análises estatísticas como Qui-cuadrado, Rho de Spearman e modelo de regressão logística. Resultados: 68.1 % presented anxiety, 64.3 % depression, 56.3 % insomnia and 85.7 % academic stress. Academic stress showed statistical association with sex, school period, diagnosis in a family member and contact with a person suspected or confirmed of having COVID-19. Presenting academic stress is 3.9 times higher with moderate anxiety, 10.6 times higher with moderate depression, 12.7 times higher with moderate clinical insomnia, 1.8 times higher with a family member diagnosed with the disease, and 2.6 times higher with contact of suspected or confirmed COVID-19 cases. Conclusões: Problemas de saúde mental foram relacionados aos níveis de estresse acadêmico em estudantes de enfermagem durante a pandemia de COVID-19. O profissional de enfermagem deve traçar estratégias educacionais e de treinamento para reduzir os níveis desses problemas, aplicáveis desde a formação educacional até o ambiente de trabalho.

Resumen Introducción: La pandemia por COVID-19 ha generado un impacto importante en la formación de profesionales de enfermería, afectando la salud mental en estudiantes debido a las experiencias enfrentadas. Objetivo: Evaluar el nivel de estrés académico en estudiantes de enfermería y su relación con la ansiedad, depresión, insomnio, estrés postraumático y experiencias durante la pandemia de COVID-19. Metodología: Estudio correlacional con 1009 estudiantes matriculados de licenciatura en enfermería que aceptaron participar. Se aplicó encuesta virtual, recolectando datos sociodemográficos y de experiencias durante la pandemia de COVID-19, además de los cuestionarios sobre ansiedad, depresión, insomnio, estrés postraumático y académico, con previa autorización del comité de investigación y ética. El análisis se realizó con Ji cuadrada, Rho de Spearman, y el modelo de regresión logística. Resultados: El 68.1 % presentaron ansiedad, el 64.3 % depresión, el 56.3 % insomnio y el 85.7 % estrés académico. El estrés académico mostró asociación estadística con sexo, periodo académico, diagnóstico en familiar y contacto con persona sospechosa/confirmada de COVID-19. Presentar estrés académico es 3.9 veces mayor con ansiedad moderada, 10.6 veces mayor con depresión moderada, 12.7 veces mayor con insomnio clínico moderado, 1.8 veces mayor con familiar diagnosticado con la enfermedad y 2.6 veces mayor con contacto de casos sospechosos/confirmados de COVID-19. Conclusión: Problemas de salud mental mostraron relación estadística con estrés académico en estudiantes de enfermería durante la pandemia por COVID-19. El profesional de enfermería debe diseñar estrategias educativas y de capacitación para disminuir los niveles de estos problemas, aplicables desde la formación hasta lo laboral.

Resumen A partir de un estudio sociodemográfico, se describe la disolución conyugal por divorcio y separación, en familias de la región fronteriza del norte de México. Se proporciona una visión general acerca del nivel de frecuencia de la inestabilidad conyugal a nivel regional y algunas de las diferencias entre las entidades federativas que la componen. Se utiliza la Encuesta Nacional de la Dinámica Demográfica (Enadid) de 2018 y otras fuentes de información secundaria. El análisis se basa en los indicadores obtenidos de las disoluciones de la primera unión conyugal de mujeres alguna vez unidas, mediante el uso de la técnica de tablas de vida y los modelos de regresión logística. Entre otros resultados, se encontró que la región norteña tiene uno de los niveles más altos de disolución conyugal en el país, pero con interesantes diferencias que destacan entre los estados del noroeste y el noreste, generando un patrón dual en la región.

Abstract This is a descriptive socio-demographic study of the marital dissolution by divorce and separation in the northern border region of Mexico. The objective is to provide a general view of the level of this type of dissolutions in the region and some of its differences among the federal entities that form it. For this purpose, we use information from the National Survey of the Demographic Dynamics 2018 (ENADID) and secondary sources of information. The analysis is based on the indicators about the dissolution of the first conjugal union of ever-married women that were calculated through the life table technique and logistic regression models. The results evidence that the northern region has one of the highest levels of marital dissolution in the country, but with interesting differences between the states located in the northwest and the northeast generating a dual pattern in the region.

Resumen Introducción: la enfermedad renal crónica (ERC) provoca cambios irreversibles en la función del riñón o en su estructura alrededor de 3 meses . Se considera en salud pública como un grave problema, dado a su comportamiento y potencial letalidad. Objetivo: determinar los factores de riesgo asociados a la progresión de la enfermedad renal crónica en pacientes atendidos en el Hospital San Juan de Dios del municipio de Pamplona, Norte de Santander durante el período 2019 - 2021. Metodología: estudio de corte transversal, analítico, retrospectivo. Se estudiaron y analizaron características sociodemográficas y clínicas mediante métodos de estadística descriptiva e inferencial, se construyó un modelo multivariado de regresión logística con nivel de significancia de 0,05. Resultados: la prevalencia de la ERC estadio 3A fue del 74,9%. Del total de pacientes incluidos en la investigación, 186 (53,7%) tuvieron reporte de progresión. El modelo multivariado indicó que ser mujer está asociado a la progresión de la enfermedad renal cuando se ajusta por TFG (OR 1,07 (IC 1,03-1,12; p = <0,001)), la edad (OR 1,07 (IC 1,03-1,11; p = <0,001)), creatinina (OR 25,2 (IC 5,10-125,1); p = <0,001)) y albuminuria (OR 1,00 (IC 0,99 - 1,01); p= <0,001)). Conclusión: se hace necesario en un futuro estudio involucrar variables de adherencia al tratamiento, así como el tiempo de evolución de la patología y algunos elementos como hábitos, estilos de vida y calidad del control.

Abstract Introduction : Chronic kidney disease (CKD) is considered in public health as a serious problem, given its behavior and lethal potential, this is defined as irreversible changes in kidney function or its structure that last at least 3 months. Objective : To determine the risk factors associated with the progression of CKD in patients treated at the Hospital San Juan de Dios in the municipality of Pamplona Norte de Santander for the period 2019 - 2021. Methodology : Cross-sectional, analytical, retrospective study. Sociodemographic and clinical characteristics were studied and analyzed using descriptive and inferential statistical methods, a multivariate logistic regression model was constructed with a significance level of 0.05. Results : The prevalence of stage 3a chronic kidney disease (CKD) was 74.9%. Out of the total patients included in the research, 186 (53.7%) showed evidence of progression. The multivariate model indicated that being female is associated with the progression of renal disease when adjusted for glomerular filtration rate (GFR) (OR 1.07 (IC 1.03-1.12; p < 0.001)), age (OR 1.07 (IC 1.03-1.11; p < 0.001)), creatinine (OR 25.2 (IC 5.1-125.1); p < 0.001)), and albuminuria (OR 1.00 (IC 0.99-1.01); p < 0.001)). Conclusions: It is necessary in a future study to involve variables of adherence to treatment and treatment, as well as the time of evolution of the pathology and some elements such as habit, lifestyles and quality of control.

Abstract Objectives This study aims to evaluate the characteristics and treatment response of patients with pityriasis lichenoides seen in the last 43 years in a pediatric dermatology service. Methods This was a retrospective, analytical, longitudinal study of patients under 15 years of age. The medical records were reviewed and data were presented as frequencies, means and variances. Student's t-test, Mann-Whitney test, Fisher's exact test, Pearson/Yates chi-square test and multivariate logistic regression model were used, with p < 0.05 considered. Results 41 patients were included, 32 (78.0%) with pityriasis lichenoides chronica (PLC), five (12.2%) with pityriasis lichenoides et varioliformis acuta (PLEVA) and four (9.8%) with clinical PLC without biopsy. The age range of school children and adolescents was 19 (46.3%) and 13 (31.7%) respectively and 27 (65.8%) were male. Two peaks of the highest frequency were observed between 2004 and 2006 (10 patients - 24.4%) and another between 2019 and 2021 (6 patients - 14.7%). There was remission in 71.9% (n = 23), with 56.6% (n = 17) of those who used antibiotic therapy and 80% (n = 4) of those who had phototherapy. The chance of remission was 13 times greater in patients with disease onset after 5 years of age. Conclusions The clinical form most commonly found was PLC mainly in school children and adolescents. The frequency peaks coincided with infectious outbreaks. The remission rate was satisfactory with antibiotic therapy, but higher with phototherapy. Remission was greater in patients with disease onset after 5 years of age. 4 service retrospective analytical 1 frequencies variances Students Student s ttest, ttest t t-test MannWhitney Mann Whitney Fishers Fisher PearsonYates Pearson Yates chisquare chi square 005 0 05 0.0 considered included 3 78.0% 780 78 (78.0% PLC, , (PLC) 12.2% 122 12 2 (12.2% PLEVA (PLEVA 9.8% 98 9 8 (9.8% biopsy 46.3% 463 46 (46.3% 31.7% 317 31 7 (31.7% 65.8% 658 65 (65.8% male 200 10 (1 24.4% 244 24 201 202 6 ( 14.7%. 147 14.7% . 14 14.7%) 719 71 71.9 n 23, 23 23) 566 56 56.6 17 80 phototherapy outbreaks 00 0. 78.0 (78.0 (PLC 12.2 (12.2 9.8 (9.8 46.3 (46.3 31.7 (31.7 65.8 (65.8 20 24.4 14.7 71. 56. 78. (78. 12. (12. 9. (9. 46. (46. 31. (31. 65. (65. 24. 14. (78 (12 (9 (46 (31 (65 (7 (4 (3

Abstract Objective To evaluate the association between inflammatory markers and abdominal fat assessed by ultrasound in prepubertal children with and without excess weight. Methods A cross-sectional study involving 241 prepubertal children, 156 with obesity, 37 with overweight, and 48 with normal weight, aged five to ten years, who were followed at a research unit on Childhood Obesity from a teaching hospital belonging to a public health system. The concentration of interleukin-6, tumor necrosis factor-α and C-reactive protein were assessed and regression analyses, considering outcome variables such as abdominal wall and intra-abdominal fat thickness measured by ultrasound, were performed. Results The findings highlighted an association between abdominal fat and inflammatory markers, even in children at this young age group. Subcutaneous fat showed a stronger association with inflammatory biomarkers compared to intra-abdominal fat when performing logistic regression, with a positive association between tumor necrosis factor-α and abdominal wall thickness equal to or greater than the 75th percentile in adjusted logistic regression (OR: 18.12; CI 95 %: 1.57: 209.55). Conclusions Abdominal wall fat, in contrast to what is often observed in adults, appears to have a greater impact on chronic inflammation related to excessive weight in very young children. crosssectional cross sectional 24 15 obesity 3 overweight 4 years system interleukin6, interleukin6 interleukin 6, 6 interleukin-6 factorα factor α Creactive C reactive analyses intraabdominal intra performed group th OR (OR 18.12 1812 18 12 9 % 1.57 157 1 57 209.55. 20955 209.55 . 209 55 209.55) adults 2 interleukin- 18.1 181 1.5 5 2095 209.5 20 18. 1. 209.

Abstract Objective Platelet to albumin ratio (PAR) and prognostic nutritional index (PNI) are potential indicators for evaluating nutritional and inflammatory status. This study aimed to examine the relationship between PAR and PNI and the acute complicated course of acute hematogenous osteomyelitis (AHO). Methods AHO patients were divided into the simple course group and the acute complicated course group. The patient's gender, age, site of infection, body temperature, laboratory results, and pathogen culture results were collected and compared. Multivariate logistic regression analysis was used to determine the independent risk factors of the acute complicated course group. The receiver operating characteristic curve was applied to determine the optimal cut-off value. Results In total, 101 AHO patients with a median age of 7.58 years were included. There were 63 cases (62.4 %) in the simple course group and 38 cases (37.6 %) in the complicated course group. Binary logistic regression analysis revealed that PAR and PNI were independent risk factors for predicting the acute complicated course of AHO (p = 0.004 and p < 0.001, respectively). Receiver operating characteristic curve analysis demonstrated that the combination of PAR and PNI had an area under the curve of 0.777 (95 % CI: 0.680-0.873, p < 0.001) with a cut-off value of 0.51. Conclusions The incidence of acute complicated courses was significantly higher in patients with high PAR and low PNI. A combined factor greater than 0.51, derived from PAR and PNI measurements within 24 h of admission, may be useful for predicting AHO patients who are likely to develop severe disease. (PAR (PNI status AHO. . (AHO) patient s gender infection temperature compared cutoff cut off total 10 758 7 58 7.5 included 6 62.4 624 62 4 (62. 3 37.6 376 37 (37. 0004 0 004 0.00 0001 001 0.001 respectively. respectively respectively) 0777 777 0.77 95 (9 CI 0.6800.873, 06800873 0.680 0.873, 680 873 0.680-0.873 051 51 0.51 2 admission disease (AHO 1 75 5 7. 62. (62 37. (37 000 00 0.0 077 77 0.7 9 ( 6800 0.6800.873 0680087 0680 0.68 0873 0.873 68 87 0.680-0.87 05 0.5 (6 (3 0. 07 0.6800.87 068008 068 0.6 087 0.87 8 0.680-0.8 0.6800.8 06800 06 08 0.8 0.680-0. 0.6800. 0.680-0 0.6800 0.680-

Objetivos: Investigar os fatores associados à disposição para conhecer o estado sorológico para a sífilis entre estudantes do ensino superior. Métodos: Estudo transversal e analítico realizado com estudantes do ensino superior de Portugal. A coleta de dados ocorreu por meio de questionário on- line. Os dados foram analisados pela regressão logística de Poisson com variância robusta, utilizando o SPSS-24. Resultados: Incluídos 413 estudantes, maioria do sexo feminino, idade média de 20,5 anos e matriculada em cursos de saúde. Observou -se vulnerabilidades comportamentais como não uso do preservativo e uso de álcool/outras drogas; baixa percepção de risco e conhecimento ruim sobre sífilis. Menos da metade dos estudantes se dispuseram a realizar o teste para sífilis. Conclusões: A adesão ao rastreio para sífilis foi baixa e associada a fatores incomuns como menor conhecimento, baixa percepção de risco, menor idade e número de parcerias sexuais e frequentar cursos de áreas diferentes da saúde.

Objectives: To investigate the factors associated with the willingness to know the serological status for syphilis among higher education students. Methods: A cross-sectional and analytical study was conducted with higher education students in Portugal. Data collection was carried out through an online questionnaire. The data were analyzed using Poisson logistic regression with robust variance, utilizing SPSS-24. Results: A total of 413 students were included, the majority of whom were female, with an average age of 20.5 years, and enrolled in health-related courses. Behavioral vulnerabilities such as not using condoms and using alcohol/other drugs were observed; there was also a low-risk perception and poor knowledge about syphilis. Less than half of the students were willing to undergo the syphilis test. Conclusions: Adherence to syphilis screening was low and associated with uncommon factors such as lower knowledge, low risk perception, younger age, fewer sexual partnerships, and enrollment in courses outside the health field.

Objetivos: Investigar los factores asociados con la disposición a conocer el estado serológico para sífilis entre estudiantes de educación superior. Métodos: Estudio transversal y analítico realizado con estudiantes de educación superior en Portugal. La recogida de datos se realizó a través de un cuestionario en línea. Los datos se analizaron mediante regresión logística de Poisson con varianza robusta, utilizando SPSS-24. Resultados: Se incluyeron 413 estudiantes, la mayoría del sexo femenino, la edad promedio fue de 20,5 años y matriculados en carreras de salud. Observar vulnerabilidades de comportamiento como no usar condones y consumir alcohol u otras drogas; baja percepción de riesgo y escaso conocimiento sobre la sífilis. Menos de la mitad de los estudiantes estaban dispuestos a realizar la prueba de sífilis. Conclusiones: La adherencia al tamizaje de sífilis fue baja y se asoció con factores obvios como menor conocimiento, baja percepción de riesgo, menor edad y número de parejas sexuales y asistencia a cursos en áreas distintas a la salud.

Abstract Introduction: Living donor kidney transplantation is considered the ideal renal replacement therapy because it has a lower complication rate and allows an efficient response to the high demand for grafts in the healthcare system. Careful selection and adequate monitoring of donors is a key element in transplantation. Individuals at greater risk of developing kidney dysfunction after nephrectomy must be identified. Objective: To identify risk factors associated with a renal compensation rate (CR) below 70% 12 months after nephrectomy. Methods: This observational retrospective longitudinal study included living kidney donors followed up at the Lower Amazon Regional Hospital between 2016 and 2022. Data related to sociodemographic variables, comorbid conditions and kidney function parameters were collected. Results: The study enrolled 32 patients. Fourteen (43.75%) had a CR < 70% 12 months after kidney donation. Logistic regression found obesity (Odds Ratio [95%CI]: 10.6 [1.7–65.2]), albuminuria (Odds Ratio [95%CI]: 2.41 [1.2–4.84]) and proteinuria (Odds Ratio [95%CI]: 1.14 [1.03–1.25]) as risk factors. Glomerular filtration rate was a protective factor (Odds Ratio [95% CI]: 0.92 [0.85–0.99]). Conclusion: Obesity, albuminuria and proteinuria adversely affected short-term renal compensation rate. Further studies are needed to uncover the prognostic implications tied to these risk factors. Our findings also supported the need for careful individualized assessment of potential donors and closer monitoring of individuals at higher risk. Introduction system identified Objective (CR 70 1 Methods 201 2022 variables collected Results 3 patients 43.75% 4375 43 75 (43.75% donation Odds 95%CI 95CI CI 95 [95%CI] 106 10 6 10. 1.7–65.2, 17652 1.7–65.2 , 7 65 2 [1.7–65.2]) 241 41 2.4 1.2–4.84 12484 4 84 [1.2–4.84] 114 14 1.1 1.03–1.25 103125 03 25 [1.03–1.25] 95% [95 CI] 092 0 92 0.9 0.85–0.99. 085099 0.85–0.99 . 85 99 [0.85–0.99]) Conclusion Obesity shortterm short term 20 202 43.75 437 (43.75 9 [95%CI 1765 1.7–65. [1.7–65.2] 24 2. 1.2–4.8 1248 8 [1.2–4.84 11 1. 1.03–1.2 10312 [1.03–1.25 [9 09 0. 08509 0.85–0.9 [0.85–0.99] 43.7 (43.7 176 1.7–65 [1.7–65.2 1.2–4. 124 [1.2–4.8 1.03–1. 1031 [1.03–1.2 [ 0850 0.85–0. [0.85–0.99 43. (43. 17 1.7–6 [1.7–65. 1.2–4 [1.2–4. 1.03–1 103 [1.03–1. 085 0.85–0 [0.85–0.9 (43 1.7– [1.7–65 1.2– [1.2–4 1.03– [1.03–1 08 0.85– [0.85–0. (4 1.7 [1.7–6 1.2 [1.2– 1.03 [1.03– 0.85 [0.85–0 ( [1.7– [1.2 1.0 [1.03 0.8 [0.85– [1.7 [1. [1.0 [0.85 [1 [0.8 [0. [0

Resumo Introdução: O transplante de rim de doador vivo é considerado a terapia renal substitutiva ideal por oferecer menor taxa de complicações e possibilitar uma resposta eficiente à grande demanda por enxertos no sistema de saúde. A seleção criteriosa e o acompanhamento adequado dos doadores constituem um pilar fundamental dessa modalidade terapêutica, sendo essencial a identificação dos indivíduos em maior risco de disfunção renal pós-nefrectomia. Objetivo: Identificar fatores de risco para uma Taxa de Compensação (TC) da função renal inferior a 70% 12 meses após a nefrectomia. Métodos: Estudo observacional, retrospectivo e longitudinal conduzido com doadores de rim vivo acompanhados no Hospital Regional do Baixo Amazonas entre 2016 e 2022. Foram coletados dados correspondentes a variáveis sociodemográficas, comorbidades e parâmetros de função renal. Resultados: Foram incluídos 32 pacientes na amostra final. Destes, 14 (43,75%) obtiveram TC < 70% 12 meses após a doação. A regressão logística identificou a obesidade (Odds Ratio [IC95%]: 10.6 [1.7–65.2]), albuminúria (Odds Ratio [IC95%]: 2.41 [1.2–4.84]) e proteinúria (Odds Ratio [IC95%]: 1.14 [1.03–1.25]) como fatores de risco. A taxa de filtração glomerular atuou como fator de proteção (Odds Ratio [IC95%]: 0.92 [0.85–0.99]). Conclusão: Obesidade, albuminúria e proteinúria demonstraram impacto negativo na taxa de compensação renal em curto prazo, o que reitera a necessidade de estudos acerca das implicações prognósticas desses fatores. Além disso, reforça-se a necessidade de avaliação cuidadosa e individualizada dos possíveis doadores, com acompanhamento rigoroso, especialmente para indivíduos de maior risco. Introdução saúde terapêutica pósnefrectomia. pósnefrectomia pós nefrectomia pós-nefrectomia Objetivo (TC 70 1 Métodos observacional 201 2022 sociodemográficas Resultados 3 final Destes 43,75% 4375 43 75 (43,75% doação Odds IC95% IC95 IC [IC95%] 106 10 6 10. 1.7–65.2, 17652 1.7–65.2 , 7 65 2 [1.7–65.2]) 241 41 2.4 1.2–4.84 12484 4 84 [1.2–4.84] 114 1.1 1.03–1.25 103125 03 25 [1.03–1.25] 092 0 92 0.9 0.85–0.99. 085099 0.85–0.99 . 85 99 [0.85–0.99]) Conclusão Obesidade prazo disso reforçase reforça se rigoroso 20 202 43,75 437 (43,75 IC9 [IC95% 1765 1.7–65. [1.7–65.2] 24 2. 1.2–4.8 1248 8 [1.2–4.84 11 1. 1.03–1.2 10312 [1.03–1.25 09 9 0. 08509 0.85–0.9 [0.85–0.99] 43,7 (43,7 [IC95 176 1.7–65 [1.7–65.2 1.2–4. 124 [1.2–4.8 1.03–1. 1031 [1.03–1.2 0850 0.85–0. [0.85–0.99 43, (43, [IC9 17 1.7–6 [1.7–65. 1.2–4 [1.2–4. 1.03–1 103 [1.03–1. 085 0.85–0 [0.85–0.9 (43 [IC 1.7– [1.7–65 1.2– [1.2–4 1.03– [1.03–1 08 0.85– [0.85–0. (4 1.7 [1.7–6 1.2 [1.2– 1.03 [1.03– 0.85 [0.85–0 ( [1.7– [1.2 1.0 [1.03 0.8 [0.85– [1.7 [1. [1.0 [0.85 [1 [0.8 [ [0. [0

Abstract Introduction: Living donor kidney transplantation is considered the ideal renal replacement therapy because it has a lower complication rate and allows an efficient response to the high demand for grafts in the healthcare system. Careful selection and adequate monitoring of donors is a key element in transplantation. Individuals at greater risk of developing kidney dysfunction after nephrectomy must be identified. Objective: To identify risk factors associated with a renal compensation rate (CR) below 70% 12 months after nephrectomy. Methods: This observational retrospective longitudinal study included living kidney donors followed up at the Lower Amazon Regional Hospital between 2016 and 2022. Data related to sociodemographic variables, comorbid conditions and kidney function parameters were collected. Results: The study enrolled 32 patients. Fourteen (43.75%) had a CR < 70% 12 months after kidney donation. Logistic regression found obesity (Odds Ratio [95%CI]: 10.6 [1.7–65.2]), albuminuria (Odds Ratio [95%CI]: 2.41 [1.2–4.84]) and proteinuria (Odds Ratio [95%CI]: 1.14 [1.03–1.25]) as risk factors. Glomerular filtration rate was a protective factor (Odds Ratio [95% CI]: 0.92 [0.85–0.99]). Conclusion: Obesity, albuminuria and proteinuria adversely affected short-term renal compensation rate. Further studies are needed to uncover the prognostic implications tied to these risk factors. Our findings also supported the need for careful individualized assessment of potential donors and closer monitoring of individuals at higher risk. Introduction system identified Objective (CR 70 1 Methods 201 2022 variables collected Results 3 patients 43.75% 4375 43 75 (43.75% donation Odds 95%CI 95CI CI 95 [95%CI] 106 10 6 10. 1.7–65.2, 17652 1.7–65.2 , 7 65 2 [1.7–65.2]) 241 41 2.4 1.2–4.84 12484 4 84 [1.2–4.84] 114 14 1.1 1.03–1.25 103125 03 25 [1.03–1.25] 95% [95 CI] 092 0 92 0.9 0.85–0.99. 085099 0.85–0.99 . 85 99 [0.85–0.99]) Conclusion Obesity shortterm short term 20 202 43.75 437 (43.75 9 [95%CI 1765 1.7–65. [1.7–65.2] 24 2. 1.2–4.8 1248 8 [1.2–4.84 11 1. 1.03–1.2 10312 [1.03–1.25 [9 09 0. 08509 0.85–0.9 [0.85–0.99] 43.7 (43.7 176 1.7–65 [1.7–65.2 1.2–4. 124 [1.2–4.8 1.03–1. 1031 [1.03–1.2 [ 0850 0.85–0. [0.85–0.99 43. (43. 17 1.7–6 [1.7–65. 1.2–4 [1.2–4. 1.03–1 103 [1.03–1. 085 0.85–0 [0.85–0.9 (43 1.7– [1.7–65 1.2– [1.2–4 1.03– [1.03–1 08 0.85– [0.85–0. (4 1.7 [1.7–6 1.2 [1.2– 1.03 [1.03– 0.85 [0.85–0 ( [1.7– [1.2 1.0 [1.03 0.8 [0.85– [1.7 [1. [1.0 [0.85 [1 [0.8 [0. [0

Resumo Introdução: O transplante de rim de doador vivo é considerado a terapia renal substitutiva ideal por oferecer menor taxa de complicações e possibilitar uma resposta eficiente à grande demanda por enxertos no sistema de saúde. A seleção criteriosa e o acompanhamento adequado dos doadores constituem um pilar fundamental dessa modalidade terapêutica, sendo essencial a identificação dos indivíduos em maior risco de disfunção renal pós-nefrectomia. Objetivo: Identificar fatores de risco para uma Taxa de Compensação (TC) da função renal inferior a 70% 12 meses após a nefrectomia. Métodos: Estudo observacional, retrospectivo e longitudinal conduzido com doadores de rim vivo acompanhados no Hospital Regional do Baixo Amazonas entre 2016 e 2022. Foram coletados dados correspondentes a variáveis sociodemográficas, comorbidades e parâmetros de função renal. Resultados: Foram incluídos 32 pacientes na amostra final. Destes, 14 (43,75%) obtiveram TC < 70% 12 meses após a doação. A regressão logística identificou a obesidade (Odds Ratio [IC95%]: 10.6 [1.7–65.2]), albuminúria (Odds Ratio [IC95%]: 2.41 [1.2–4.84]) e proteinúria (Odds Ratio [IC95%]: 1.14 [1.03–1.25]) como fatores de risco. A taxa de filtração glomerular atuou como fator de proteção (Odds Ratio [IC95%]: 0.92 [0.85–0.99]). Conclusão: Obesidade, albuminúria e proteinúria demonstraram impacto negativo na taxa de compensação renal em curto prazo, o que reitera a necessidade de estudos acerca das implicações prognósticas desses fatores. Além disso, reforça-se a necessidade de avaliação cuidadosa e individualizada dos possíveis doadores, com acompanhamento rigoroso, especialmente para indivíduos de maior risco. Introdução saúde terapêutica pósnefrectomia. pósnefrectomia pós nefrectomia pós-nefrectomia Objetivo (TC 70 1 Métodos observacional 201 2022 sociodemográficas Resultados 3 final Destes 43,75% 4375 43 75 (43,75% doação Odds IC95% IC95 IC [IC95%] 106 10 6 10. 1.7–65.2, 17652 1.7–65.2 , 7 65 2 [1.7–65.2]) 241 41 2.4 1.2–4.84 12484 4 84 [1.2–4.84] 114 1.1 1.03–1.25 103125 03 25 [1.03–1.25] 092 0 92 0.9 0.85–0.99. 085099 0.85–0.99 . 85 99 [0.85–0.99]) Conclusão Obesidade prazo disso reforçase reforça se rigoroso 20 202 43,75 437 (43,75 IC9 [IC95% 1765 1.7–65. [1.7–65.2] 24 2. 1.2–4.8 1248 8 [1.2–4.84 11 1. 1.03–1.2 10312 [1.03–1.25 09 9 0. 08509 0.85–0.9 [0.85–0.99] 43,7 (43,7 [IC95 176 1.7–65 [1.7–65.2 1.2–4. 124 [1.2–4.8 1.03–1. 1031 [1.03–1.2 0850 0.85–0. [0.85–0.99 43, (43, [IC9 17 1.7–6 [1.7–65. 1.2–4 [1.2–4. 1.03–1 103 [1.03–1. 085 0.85–0 [0.85–0.9 (43 [IC 1.7– [1.7–65 1.2– [1.2–4 1.03– [1.03–1 08 0.85– [0.85–0. (4 1.7 [1.7–6 1.2 [1.2– 1.03 [1.03– 0.85 [0.85–0 ( [1.7– [1.2 1.0 [1.03 0.8 [0.85– [1.7 [1. [1.0 [0.85 [1 [0.8 [ [0. [0

Resumo Introdução: Nonagenários constituem um percentual de pacientes internados em ascensão, sendo a injúria renal aguda (IRA) frequente nesses pacientes. Sendo assim, é importante analisar as características clínicas dessa população e seu impacto na mortalidade. Métodos: Estudo retrospectivo de pacientes nonagenários com IRA entre 2013 e 2022 em um hospital terciário. Apenas o último internamento foi considerado e pacientes com dados incompletos foram excluídos. Uma análise por regressão logística foi realizada para definir fatores de risco para mortalidade. Um valor de p < 0,05 foi considerado significativo. Resultados: Foram incluídos 150 pacientes com mediana de idade 93,0 anos (91,2–95,0) e sexo masculino em 42,7%. Sepse foi a causa mais comum de IRA (53,3%), seguida de desidratação/hipovolemia (17,7%) e insuficiência cardíaca (17,7%). Admissão na UTI ocorreu em 39,3% dos pacientes, ventilação mecânica em 14,7%, uso de vasopressores em 22,7% e realização de terapia renal substitutiva (TRS) em 6,7%. Óbito ocorreu em 56,7% dos pacientes. Desidratação/hipovolemia como etiologia da IRA foi associado a menor risco de mortalidade (OR 0,18; IC 95% 0,04–0,77, p = 0,020). Estágio KDIGO 3 (OR 3,15; IC 95% 1,17–8,47, p = 0,023), admissão na UTI (OR 12,27; IC 95% 3,03–49,74, p < 0,001) e oligúria (OR 5,77; IC 95% 1,98–16,85, p = 0,001) foram associados à mortalidade. Conclusão: Nonagenários com IRA apresentaram alta mortalidade e IRA KDIGO 3, oligúria e admissão na UTI foram associadas ao óbito. Introdução ascensão (IRA assim Métodos 201 202 terciário excluídos 005 0 05 0,0 significativo Resultados 15 930 93 93, 91,2–95,0 912950 91 2 95 (91,2–95,0 427 42 7 42,7% 53,3%, 533 53,3% , 53 (53,3%) desidrataçãohipovolemia desidratação hipovolemia 17,7% 177 17 (17,7% 17,7%. . 393 39 39,3 147 14 14,7% 227 22 22,7 TRS (TRS 67 6 6,7% 567 56 56,7 Desidrataçãohipovolemia Desidratação OR 0,18 018 18 004077 04 77 0,04–0,77 0,020. 0020 0,020 020 0,020) 3,15 315 117847 1 8 47 1,17–8,47 0,023, 0023 0,023 023 0,023) 12,27 1227 12 27 3034974 03 49 74 3,03–49,74 0,001 0001 001 5,77 577 5 1981685 98 16 85 1,98–16,85 Conclusão óbito 20 00 0, 9 91,2–95, 91295 (91,2–95, 4 42,7 53,3 (53,3% 17,7 (17,7 39, 14,7 22, 6,7 56, 0,1 01 00407 0,04–0,7 002 0,02 02 3,1 31 11784 1,17–8,4 12,2 122 303497 3,03–49,7 0,00 000 5,7 57 198168 1,98–16,8 91,2–95 9129 (91,2–95 42, 53, (53,3 17, (17, 14, 6, 0040 0,04–0, 1178 1,17–8, 12, 30349 3,03–49, 5, 19816 1,98–16, 91,2–9 912 (91,2–9 (53, (17 004 0,04–0 117 1,17–8 3034 3,03–49 1981 1,98–16 91,2– (91,2– (53 (1 0,04– 11 1,17– 303 3,03–4 198 1,98–1 91,2 (91,2 (5 ( 0,04 1,17 30 3,03– 19 1,98– 91, (91, 1,1 3,03 1,98 (91 1, 3,0 1,9 (9

Abstract Introduction: Nonagenarians constitute a rising percentage of inpatients, with acute kidney injury (AKI) being frequent in this population. Thus, it is important to analyze the clinical characteristics of this demographic and their impact on mortality. Methods: Retrospective study of nonagenarian patients with AKI at a tertiary hospital between 2013 and 2022. Only the latest hospital admission was considered, and patients with incomplete data were excluded. A logistic regression analysis was conducted to define risk factors for mortality. A p-value < 0.05 was considered statistically significant. Results: A total of 150 patients were included, with a median age of 93.0 years (91.2–95.0), and males accounting for 42.7% of the sample. Sepsis was the most common cause of AKI (53.3%), followed by dehydration/hypovolemia (17.7%), and heart failure (17.7%). ICU admission occurred in 39.3% of patients, mechanical ventilation in 14.7%, vasopressors use in 22.7% and renal replacement therapy (RRT) in 6.7%. Death occurred in 56.7% of patients. Dehydration/hypovolemia as an etiology of AKI was associated with a lower risk of mortality (OR 0.18; 95% CI 0.04–0.77, p = 0.020). KDIGO stage 3 (OR 3.15; 95% CI 1.17–8.47, p = 0.023), ICU admission (OR 12.27; 95% CI 3.03–49.74, p < 0.001), and oliguria (OR 5.77; 95% CI 1.98–16.85, p = 0.001) were associated with mortality. Conclusion: AKI nonagenarians had a high mortality rate, with AKI KDIGO stage 3, oliguria, and ICU admission being associated with death. Introduction inpatients (AKI population Thus Methods 201 2022 excluded pvalue value 005 0 05 0.0 significant Results 15 included 930 93 93. 91.2–95.0, 912950 91.2–95.0 , 91 2 95 (91.2–95.0) 427 42 7 42.7 sample 53.3%, 533 53.3% 53 (53.3%) dehydrationhypovolemia dehydration hypovolemia 17.7%, 177 17.7% 17 (17.7%) 17.7%. . 393 39 39.3 147 14 14.7% 227 22 22.7 RRT (RRT 67 6 6.7% 567 56 56.7 Dehydrationhypovolemia Dehydration OR 0.18 018 18 004077 04 77 0.04–0.77 0.020. 0020 0.020 020 0.020) 3.15 315 117847 1 8 47 1.17–8.47 0.023, 0023 0.023 023 0.023) 12.27 1227 12 27 3034974 03 49 74 3.03–49.74 0.001, 0001 0.001 001 5.77 577 5 1981685 98 16 85 1.98–16.85 Conclusion rate death 20 202 00 0. 9 91295 91.2–95. (91.2–95.0 4 42. 53.3 (53.3% 17.7 (17.7% 39. 14.7 22. 6.7 56. 0.1 01 00407 0.04–0.7 002 0.02 02 3.1 31 11784 1.17–8.4 12.2 122 303497 3.03–49.7 000 0.00 5.7 57 198168 1.98–16.8 9129 91.2–95 (91.2–95. 53. (53.3 17. (17.7 14. 6. 0040 0.04–0. 3. 1178 1.17–8. 12. 30349 3.03–49. 5. 19816 1.98–16. 912 91.2–9 (91.2–95 (53. (17. 004 0.04–0 117 1.17–8 3034 3.03–49 1981 1.98–16 91.2– (91.2–9 (53 (17 0.04– 11 1.17– 303 3.03–4 198 1.98–1 91.2 (91.2– (5 (1 0.04 1.17 30 3.03– 19 1.98– 91. (91.2 ( 1.1 3.03 1.98 (91. 1. 3.0 1.9 (91 (9