RESUMO Objetivo: Comparar a presença de anticorpos neutralizantes contra o SARS-CoV-2 no leite materno e no sangue das lactantes vacinadas em relação àquelas não vacinadas. Fontes de dados: Foi efetuado registro no International Prospective Register of Systematic Reviews — PROSPERO (CRD42021287554) e foram seguidas as diretrizes do Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Foram elegíveis estudos de coorte, caso-controle e transversais que avaliaram anticorpos contra o SARS-CoV-2 no leite e no sangue de lactantes vacinadas e tiveram como grupo controle lactantes não vacinadas. Utilizaram-se os Descritores em Ciências da Saúde (DeCs), Medical Subject Heading (MeSH) e Emtree para as bases Biblioteca Virtual em Saúde (BVS), Medical Literature Analysis and Retrieval System Online (Medline/PubMed) e Embase, respectivamente. Na Web of Science e Scopus foi feita adaptação da estratégia. Não foram estabelecid as restrições quanto ao período de publicação e idioma. Síntese dos dados: As buscas identificaram 233 registros. Foram excluídos 128 duplicados e 101 fora dos critérios de inclusão, e quatro estudos de coorte foram elegíveis. As lactantes vacinadas com Pfizer-BioNTech e Moderna apresentaram anticorpos contra SARS-CoV-2 no sangue e no leite materno. Conclusões: As mulheres lactantes vacinadas apresentaram níveis mais elevados de imunoglobulina G (IgG) e A (IgA) no soro e no leite materno em comparação com as mulheres não vacinadas. Objetivo SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- dados CRD42021287554 CRD (CRD42021287554 MetaAnalysis Meta PRISMA. PRISMA . (PRISMA) casocontrole caso Utilizaramse Utilizaram se DeCs, DeCs , (DeCs) MeSH (MeSH BVS, BVS (BVS) Medline/PubMed MedlinePubMed Medline PubMed (Medline/PubMed Embase respectivamente estratégia idioma 23 registros 12 10 inclusão PfizerBioNTech Pfizer BioNTech Conclusões IgG (IgG IgA (IgA SARS-CoV CRD4202128755 (CRD4202128755 (PRISMA (DeCs (BVS 1 CRD420212875 (CRD420212875 CRD42021287 (CRD42021287 CRD4202128 (CRD4202128 CRD420212 (CRD420212 CRD42021 (CRD42021 CRD4202 (CRD4202 CRD420 (CRD420 CRD42 (CRD42 CRD4 (CRD4 (CRD

ABSTRACT Objective: To compare the presence of neutralizing antibodies against SARS-CoV-2 found in the breast milk and blood of vaccinated lactating women with those not vaccinated. Data source: The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021287554 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort, case-control, and cross-sectional studies that evaluated antibodies against SARS-CoV-2 in the milk and blood of vaccinated mothers and had as control group unvaccinated mothers were eligible. Health Sciences Descriptors (DeCs), Medical Subject Headings (MeSH) and Emtree descriptors were used for the Virtual Health Library (VHL), Medical Literature Analysis and Retrieval System Online (Medline/Pubmed), and Embase databases, respectively. In the Web of Science and Scopus, the strategy was adapted. No restrictions on the publication period and language were set. Data synthesis: The search identified 233 records, of which 128 duplicates and 101 papers that did not meet the inclusion criteria were excluded. Hence, four cohort studies were eligible. Nursing mothers vaccinated with the Pfizer-BioNTech and Moderna vaccines showed antibodies against SARS-CoV-2 in their blood and breast milk. Conclusions: Vaccinated lactating women had higher levels of immunoglobulin G (IgG) and A (IgA) in serum and breast milk than unvaccinated women. Objective SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- source PROSPERO (PROSPERO CRD CRD4202128755 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines Cohort casecontrol, casecontrol case control, case-control crosssectional cross sectional eligible DeCs, DeCs , (DeCs) MeSH (MeSH VHL, VHL (VHL) Medline/Pubmed, MedlinePubmed Medline/Pubmed Medline Pubmed (Medline/Pubmed) databases respectively Scopus adapted set synthesis 23 records 12 10 excluded Hence PfizerBioNTech Pfizer BioNTech Conclusions IgG (IgG IgA (IgA SARS-CoV CRD420212875 (DeCs (VHL (Medline/Pubmed 1 CRD42021287 CRD4202128 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Verificar a utilização e identificar as vantagens dos métodos moleculares para diagnóstico de infecções congênitas no líquido cefalorraquidiano de neonatos. Fontes de dados: A revisão foi registrada na base PROSPERO (International Prospective Register of Systematic Reviews) sob CRD42021274210. A busca bibliográfica foi realizada nas bases de dados PubMed, Biblioteca Virtual em Saúde/ Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde (BVS/BIREME), Scopus, Web of Science, Excerpta Medica database (EMBASE), Cochrane, ProQuest, e EBSCOhost. A busca foi feita no período de agosto a outubro de 2021 e atualizada em dezembro de 2022, respeitando as orientações do Preferred Reporting Items for Systematic Reviews e Meta-Analyises (PRISMA). A sequência da seleção dos estudos foi: 1) Remoção de duplicatas; 2) Exame de títulos e resumos; 3) Recuperação dos textos completos potencialmente relevantes; e 4) Avaliação do texto completo conforme critérios de elegibilidade por dois autores independentes. O critério de inclusão considerou ensaios clínicos randomizados e não randomizados, estudos longitudinais, transversais, revisados por pares, estudos em humanos, publicados em inglês, espanhol, italiano e português, com recém-nascidos de até 28 dias que sofreram neuroinfecções congênitas pelos agentes toxoplasmose, rubéola, citomegalovírus, herpes simples (TORCH), e outros como Treponema pallidum, Zika, parvovírus B-19, varicela zoster, Epstein-Barr, e SARS-CoV-2, diagnosticadas por reação em cadeia de polimerase (PCR). Dois avaliadores extraíram as seguintes informações: autor, ano de publicação, nacionalidade, sujeitos, tipo de estudo, métodos, resultados e conclusão. Síntese dos dados: O patógeno mais estudado foi Herpes Simples. Muitos artigos relataram somente sintomas iniciais inespecíficos, motivando a coleta de líquido cefalorraquidiano e realização da PCR para investigação etiológica. Conclusões: Os métodos moleculares são eficazes para detectar o genoma do patógeno no líquido cefalorraquidiano, o que pode impactar na evolução clínica e no prognóstico neurológico. Objetivo neonatos International CRD42021274210 CRD PubMed LatinoAmericano Latino Americano BVS/BIREME, BVSBIREME BVS/BIREME , BVS BIREME (BVS/BIREME) Scopus Science EMBASE, EMBASE (EMBASE) Cochrane ProQuest EBSCOhost 202 2022 MetaAnalyises Meta Analyises PRISMA. PRISMA . (PRISMA) 1 duplicatas 2 resumos 3 relevantes 4 independentes longitudinais transversais pares humanos inglês espanhol português recémnascidos recém nascidos toxoplasmose rubéola citomegalovírus TORCH, TORCH (TORCH) pallidum Zika B19, B19 B 19, 19 B-19 zoster EpsteinBarr, EpsteinBarr Epstein Barr, Barr Epstein-Barr SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2, SARS-CoV-2 PCR. (PCR) informações autor publicação nacionalidade sujeitos estudo conclusão Simples inespecíficos etiológica Conclusões neurológico CRD4202127421 (BVS/BIREME (EMBASE 20 (PRISMA (TORCH B1 B-1 SARS-CoV- (PCR CRD420212742 B- SARS-CoV CRD42021274 CRD4202127 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

ABSTRACT Objective: To verify the use and identify advantages of molecular methods for congenital infections diagnosis in cerebrospinal fluid of neonates. Data source: The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), under CRD42021274210. The literature search was performed in databases: PubMed, Virtual Health Library/ Latin American and Caribbean Center on Health Sciences Information (VHL/BIREME), Scopus, Web of Science, Excerpta Medica database (EMBASE), Cochrane, ProQuest, and EBSCOhost. The search was carried out from August to October 2021 and updated in December 2022, respecting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The selection sequence was: 1) Duplicate title removal; 2) Examination of titles and abstracts; 3) Full-text retrieval of potentially relevant reports; and 4) Evaluation of the full text according to eligibility criteria by two independent authors. Inclusion criteria considered randomized and non-randomized control trials, longitudinal, cross-sectional, and peer-reviewed studies in humans, published in English, Spanish, Italian, and Portuguese, with newborns up to 28 days old who had congenital neuroinfections by toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH), and others such as Treponema pallidum, Zika, parvovirus B-19, varicella zoster, Epstein-Barr, and SARS-CoV2, diagnosed by polymerase chain reaction (PCR). Two evaluators extracted the following information: author, year of publication, nationality, subjects, study type, methods, results, and conclusion. Data synthesis: The most studied pathogen was herpes simplex. Several articles reported only nonspecific initial symptoms, motivating the collection of cerebrospinal fluid and performing PCR for etiological investigation. Conclusions: Molecular methods are effective to detect pathogen genomes in cerebrospinal fluid, which can impact clinical evolution and neurological prognosis. Objective neonates source PROSPERO, PROSPERO , (PROSPERO) CRD42021274210 CRD databases PubMed Library VHL/BIREME, VHLBIREME VHL/BIREME VHL BIREME (VHL/BIREME) Scopus Science EMBASE, EMBASE (EMBASE) Cochrane ProQuest EBSCOhost 202 2022 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines 1 removal 2 abstracts 3 Fulltext Full reports 4 authors nonrandomized non trials longitudinal crosssectional, crosssectional cross sectional, sectional cross-sectional peerreviewed peer reviewed humans English Spanish Italian Portuguese toxoplasmosis rubella cytomegalovirus TORCH, TORCH (TORCH) pallidum Zika B19, B19 B 19, 19 B-19 zoster EpsteinBarr, EpsteinBarr Epstein Barr, Barr Epstein-Barr SARSCoV2, SARSCoV2 SARSCoV SARS CoV2, CoV2 CoV SARS-CoV2 PCR. . (PCR) information author publication nationality subjects type results conclusion synthesis symptoms investigation Conclusions prognosis (PROSPERO CRD4202127421 (VHL/BIREME (EMBASE 20 (TORCH B1 B-1 SARS-CoV (PCR CRD420212742 B- CRD42021274 CRD4202127 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

Abstract Objective This study aimed to review literature from the past five years, focusing on the use of educational videos as a guidance tool for parents and guardians of children with lip and palate clefts. Source of data Conducted between April and July 2022, this integrative literature review was framed around the question: 'What is the evidence regarding the use of videos in health education for parents/guardians of children with cleft lip and palate? PICO strategy was used to develop the research. A literature search was undertaken across PubMed, Web of Science, Scopus, and the Virtual Health Library databases. Of the eight articles included in this review, four were sourced from the PubMed database, with three published in 2021. Summary of the findings The findings indicated that YouTube videos were moderately satisfactory and met the needs of parents or legal guardians to a partial extent. The majority of the videos analyzed in this review were characterized by a moderate level of informational content. One study particularly underscored that the content of these videos only partially satisfies the requirements of the parents or legal guardians of the children. Conclusions Nevertheless, such videos are considered viable alternatives for health education, offering numerous benefits yet facing challenges, primarily due to the scarcity of information on orofacial malformations. years clefts 2022 question What parentsguardians research Science Scopus databases database 2021 extent Nevertheless challenges malformations 202 20 2

Esta revisão de escopo buscou investigar se e como a história das facções criminais oriundas do estado do Rio de Janeiro tem sido abordada na literatura científica. A pergunta de pesquisa foi: “como a história, percursos e desdobramentos da atuação das facções criminais oriundas do estado do Rio de Janeiro são descritos pela literatura científica?”. Para respondê-la, buscou publicações nas bases da Biblioteca Virtual em Saúde (BVS), SciELO, Scopus e Web Of Science. Foi adotado o procedimento duplo-cego para a seleção de publicações e o Guia PRISMA-ScR para sumarização dos resultados. Verificou-se que a história destas facções não foi objeto principal dos estudos, sendo abordada por eles de maneira breve e pontual. As formas de conceituá-las variavam desde as que enfatizavam sua atuação no tráfico; que destacavam seu caráter cultural; seu caráter de governança; seu caráter de resistência política. Quanto à história das facções, alguns trabalhos trouxeram dados sobre sua origem; outros sobre sua trajetória no mercado do tráfico; sobre o surgimento de uma “cultura de facção”; sobre a relação entre facções e Estado. As diferentes formas de conceituá-las e o destaque de certos aspectos de sua história em detrimento de outros seguem a tendência da literatura mais abrangente sobre o tema.

This scoping review aimed to investigate whether and how the history of criminal factions originating from the state of Rio de Janeiro has been addressed in the scientific literature. The research question was: “How are the history, pathways, and developments of the activities of criminal factions from the state of Rio de Janeiro described in the scientific literature?” To answer this, publications were searched in the Virtual Health Library (BVS), SciELO, Scopus, and Web of Science databases. A double-blind procedure was adopted for the selection of publications, and the PRISMA-ScR guidelines were used to summarize the results. It was found that the history of these factions was not the main focus of the studies, being briefly and sporadically addressed. The ways of conceptualizing them varied, ranging from those that emphasized their involvement in drug trafficking, their cultural nature, their governance structure, or their role in political resistance. Regarding the history of the factions, some studies provided data on their origins, others on their trajectory in the drug market, the emergence of a “faction culture” or the relationship between factions and the state. The different ways of conceptualizing these factions and the emphasis on certain aspects of their history over others reflect trends in the broader literature on the subject.

Abstract Introduction Benign paroxysmal positional vertigo (BPPV) is the peripheral vestibular dysfunction that most affects people worldwide, but its etiopathogenesis is still not fully understood. Considering the etiological diversity, some studies highlight the association between BPPV and thyroid diseases. Objective To investigate the association between thyroid diseases and BPPV. Data Synthesis Systematic review and meta-analysis of epidemiological studies searched in the PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases. Studies that were fully available and investigated the association between BPPV and thyroid diseases were selected. The articles that composed the meta-analysis were analyzed using the dichotomous model, the Mantel-Haenszel statistical test, odds ratio (OR), and a 95% confidence interval (CI). Of the 67 articles retrieved from the databases, 7 met the eligibility criteria of the systematic review, and 4 had data necessary to perform the meta-analysis. Qualitative analysis revealed that the studies were conducted in the European and Asian continents. The predominant methodological design was the case-control type, and thyroid dysfunctions, hypothyroidism, and Hashimoto thyroiditis occurred more frequently. The meta-analysis showed no association between hypothyroidism and BPPV; however, there was a statistically significant relationship between Hashimoto thyroiditis and BPPV. Conclusion The meta-analysis results suggest a possible association between BPPV and Hashimoto thyroiditis. Nevertheless, we emphasize the need for further studies to elucidate the evidence obtained. (BPPV worldwide understood diversity metaanalysis meta PubMed Science Embase Library databases selected model MantelHaenszel Mantel Haenszel test OR, OR , (OR) 95 CI. CI . (CI) 6 metaanalysis. analysis. continents casecontrol case control type dysfunctions frequently however Nevertheless obtained (OR 9 (CI

Abstract Introduction CyberKnife (CK) radiosurgery is a treatment strategy for vestibular schwannoma (VS). Objectives To evaluate hearing preservation (HP) after CK for VS. Data Synthesis The study was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, and it was registered at the International Prospective Register of Systematic Reviews (PROSPERO, under number CRD42021250300). The inclusion criteria were based on the population, intervention, comparison, outcome, timing and study design (PICOTS) strategy: population – patients with VS; intervention – CK; Comparison – none; Outcome – serviceable HP defined by Gardner and Robertson as grades I or II, or by the American Academy of Otolaryngology and Head and Neck Surgery as classes A or B; timing – mean follow-up longer than 1 year; and study design – retrospective or prospective studies. The exclusion criteria were: studies not published in English; studies published before January 2000 and after October 2021; and studies only including patients with neurofibromatosis type 2 or submitted to a previous treatment. The PubMed/MEDLINE, EMBASE, Web of Science, Cochrane Library, LILACS, and IBECS databases were used and last searched on October 27th, 2021. Statistical heterogeneity was assessed using I2 statistics. The appraisal checklist was used to assess the risk of bias in the included studies. A total of 222 studies were analyzed, and 13 were included in the synthesis, which represents 493 participants with serviceable hearing before intervention. The mean HP rate after CK using a random effects model was of 68% (95% confidence interval [95%CI]: 59–76%) at a mean follow-up of 42.96 months. Conclusion The longer follow-up period was associated with a lower HP rate after CK radiosurgery for VS in the qualitative synthesis. (CK . (VS) (HP MetaAnalyses Meta Analyses PRISMA (PRISMA statement PROSPERO, PROSPERO (PROSPERO CRD42021250300. CRD42021250300 CRD CRD42021250300) comparison outcome PICOTS (PICOTS none II B followup follow up year English 200 2021 PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE EMBASE Science Library LILACS 27th th statistics 22 analyzed synthesis 49 68 95% 95 (95 95%CI 95CI CI [95%CI] 59–76% 5976 59 76 4296 42 96 42.9 months (VS CRD4202125030 20 202 4 6 9 (9 [95%CI 59–76 597 5 7 429 42. CRD420212503 ( 59–7 CRD42021250 59– CRD4202125 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

Abstract Objective: Emergence delirium is a common complication in children. Recorded mother’s voice, as a non-pharmacological measure, is increasingly used to prevent the emergence of delirium in pediatric patients, but sufficient evidence is still needed to prove its efficacy. Methods: Embase, PubMed, Cochrane Library, Web of Science, CINAHL, and Sinomed databases were searched for randomized controlled trials exploring the efficacy of recorded mother’s voice in preventing the emergence of delirium in pediatric patients undergoing general anesthesia. The original data were pooled for the meta-analysis with Review Manager 5.4.1. This study was conducted based on the Cochrane Review Methods. Results: Eight studies with 724 children were included in the analysis. Recorded mother’s voice reduced the incidence of emergence delirium when compared with either no voice (RR: 0.45; [95 % CI, 0.34 - 0.61]; p < 0.01; I2 = 7 %) or stranger’s voice (RR: 0.51; [95 % CI, 0.28 - 0.91]; p = 0.02; I2 = 38 %) without increasing other untoward reactions. In addition, it shortened the post-anesthesia care unit stay time when compared with no voice (MD = -5.64; [95 % CI, -8.43 to -2.58]; p < 0.01, I2 = 0 %), but not stranger’s voice (MD = -1.23; [95 % CI, -3.08 to 0.63]; p = 0.19, I2 = 0 %). It also shortened the extubation time and reduced the incidence of postoperative rescue analgesia. Conclusion: The current analysis indicated that recorded mother’s voices could reduce the incidence of emergency delirium, shorten post-anesthesia care unit stay time and extubation time, and decrease the incidence of postoperative rescue analgesia in children. Objective mothers mother s nonpharmacological non pharmacological measure Methods Embase PubMed Library Science CINAHL anesthesia metaanalysis meta 541 5 4 1 5.4.1 Results 72 RR (RR 0.45 045 45 95 [9 CI 034 34 0.3 0.61 061 61 0.61] 0.01 001 01 I strangers stranger 0.51 051 51 028 28 0.2 0.91 091 91 0.91] 0.02 002 02 3 reactions addition postanesthesia post MD 5.64 564 64 -5.64 8.43 843 8 43 -8.4 2.58 258 2 58 -2.58] %, , 1.23 123 23 -1.23 3.08 308 08 -3.0 0.63 063 63 0.63] 019 19 0.19 %. . Conclusion 54 5.4. 0.4 04 9 [ 03 0. 0.6 06 6 0.0 00 0.5 05 0.9 09 5.6 56 -5.6 8.4 84 -8. 2.5 25 -2.58 1.2 12 -1.2 3.0 30 -3. 0.1 5.4 5. -5. 8. -8 2. -2.5 1. -1. 3. -3 -5 -2. -1 -2

ABSTRACT Background: Immunomodulatory drugs and immunotherapies are being evaluated in clinical trials for the treatment of neuroinflammation, as the latter is an essential mechanism for the development and progression of Parkinson´s disease. Objective: The objective of the study is to review recent evidence on the evaluation of immunomodulators in randomized controlled clinical trials measuring improvement of motor symptoms. Methods: A meta-analysis of Movement Disorder Society-Unified Parkinson´s disease Rating Scale (MDS-UPDRS III) scores extracted from seven articles selected after an online search of PubMed, Cochrane Library, and Clarivate's Web of Science for randomized controlled clinical trials published between 2000 and July 2023 was performed. The selected articles reported clinical trials evaluating the effects of specific immunomodulators or treatments with known effects on the immune system and inflammation. MDS-UPDRS III scores were reported in these studies, and the results of the placebo groups were compared with those of the treatment groups. Results: A total of 590 patients treated with immunomodulators and 622 patients treated with placebo were included. A test for heterogeneity yielded an I2 value > 50%. The mean standard difference for change in MDS-UPDR III score was −0.46 (CI [95%] = −0.90 - −0.02, p < 0.01). No significant differences were found in the change in mean MDS-UPDR III score between the treatment and placebo groups; however, two studies showed a trend toward separation from the mean. Conclusion: The immunomodulatory treatments included in this study showed no efficacy in improving motor symptoms in Parkinson´s disease patients. Further clinical trials with larger patient populations are needed.

Resumen El presente trabajo tiene como objetivo analizar las implicaciones para las ciencias sociales que presentan los delitos en línea, específicamente la estafa y la pederastia en Ecuador. La metodología utilizada se justifica en la concepción de las revisiones sistematizadas, empleándose el marco analítico de revisiones sistematizadas en Ciencias Humanas y Sociales. Se utilizaron bases de datos como Google Scholar, SCOPUS, Web of Science (WOS), Scientific Electronic Library Online (Scielo), entre otras. Las conclusiones señalan la necesidad de incrementar las investigaciones sobre estos delitos desde las ciencias sociales, la aplicación del enfoque fenomenológico, la investigación de los mitos y creencias sobre estos fenómenos, el fomento de políticas públicas y fomento de la interdisciplinariedad con otras ciencias del comportamiento.

Abstract The objective of this paper is to analyze the implications for the social sciences of online crimes, specifically fraud and pedophilia in Ecuador. The methodology used is justified in the conception of systematized reviews, using the analytical framework of systematized reviews in Human and Social Sciences. Databases such as Google Scholar, SCOPUS, Web of Science (WOS), Scientific Electronic Library Online (Scielo), among others, were used. The conclusions point to the need to increase research on these crimes from the social sciences, the application of the phenomenological approach, the investigation of myths and beliefs about these phenomena, the promotion of public policies and the promotion of interdisciplinarity with other behavioral sciences.

ABSTRACT Background: Parasacral Transcutaneous Electrical Nerve Stimulation (PTENS) is a treatment used in enuresis refractory to first-line treatment. This review aimed to evaluate the effectiveness of PTENS in treating monosymptomatic enuresis (MNE) in children and adolescents. Methods: The study followed the Preferred Reporting Items for Systematic (PRISMA) guidelines. The search was carried out in the following databases: MEDLINE (via PubMed), Web of Science, SCOPUS, Central Cochrane Library and Physiotherapy Evidence Database (PEDro). The selected studies were randomized clinical trials (RCTs). The "Risk of Bias tool for randomized trials" and the "Risk of Bias VISualization" were used to analyze the risk of bias. Results: Of the 624 studies selected, four RCTs were eligible. Three included 146 children and adolescents aged between six and 16.3 years and used similar PTENS protocols with a frequency of 10 Hz, pulse duration of 700 µs and 20 minutes three times/week. One study enrolled 52 patients aged seven to 14 years used PTENS at home, with a pulse duration of 200 µs and 20 to 60 minutes twice/day. Risk of bias was observed in three studies due to results’ randomization and measurement. Two studies showed a partial response with a reduction in wet nights, one a complete response in 27% of patients, and one showed no improvement. Conclusion: PTENS reduces wet nights’ frequency but does not cure them, except in 27% of patients in one study. Limited RCTs and data heterogeneity are limitations. Background (PTENS firstline first line MNE (MNE Methods PRISMA (PRISMA guidelines databases via PubMed, PubMed , PubMed) Science SCOPUS PEDro. PEDro . (PEDro) RCTs. (RCTs) VISualization Results 62 eligible 163 16 3 16. 1 Hz 70 2 timesweek times week times/week 5 home 6 twiceday twice day twice/day results measurement nights 27 improvement Conclusion them limitations (PEDro (RCTs 7

Bibliometrics is the application of statistical methods to analyze books, articles and other publications, especially scientific ones. Closely related to scientometrics and informetrics, to the point of overlapping and confusing. Bibliometrics refers to the study of the dynamics of the disciplines reflected in the production of their literature. It includes everything from the record of changes in the production of an academic discipline over time and between countries or regions, to the problem of the library collection. In this article some historical concepts, definitions and objectives of bibliometrics will be explained; as well as the Laws of bibliometrics; the types of analysis and bibliometric indicators most used; to finish with some examples of different types of published bibliometric studies, so that the reader can form a general idea of what he can do in this field, applying these methodologies to surgical disciplines and others as well. The aim of this manuscript was to generate a study document regarding bibliometrics as an alternative to develop research in surgery and related disciplines.

Resumen La bibliometría es la aplicación de métodos estadísticos para analizar libros, artículos y otras publicaciones, especialmente científicos. Muy relacionada con la cienciometría e informetría, al punto de superponerse y confundirse. La bibliometría se refiere al estudio de la dinámica de las disciplinas reflejado en la producción de su literatura. Incluye desde el registro de cambios en la producción de una disciplina académica a lo largo del tiempo y entre países, hasta el problema de la colección bibliotecaria. En este artículo se explicarán algunos conceptos históricos, definiciones y objetivos de la bibliometría; así como las Leyes de la bibliometría; los tipos de análisis e indicadores bibliométricos más utilizados; para terminar con algunos ejemplos de diferentes tipos de estudios bibliométricos publicados, para que el lector pueda formarse una idea general de lo que puede hacer en este campo, aplicando estas metodologías a disciplinas quirúrgicas y otras también. El objetivo de este manuscrito fue generar un documento de estudio respecto de la bibliometría como alternativa para desarrollar investigación en cirugía y disciplinas afines.

RESUMEN Introducción: El entrenamiento de fuerza está asociado con cambios positivos hacia un envejecimiento saludable y con calidad de vida, dado que previenen las lesiones, fragilidad, así como las caídas. Objetivo: El objetivo de este estudio fue evaluar la evidencia científica disponible sobre los efectos del entrenamiento de fuerza en la prevención de caídas en personas mayores. Metodología: Se realizó una búsqueda de artículos científicos en las bases de datos Medline vía PubMed, Web of Science (WOS) y Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS) vía Biblioteca Virtual de Salud (BVS) que cumplieran con los criterios de elegibilidad; el análisis se realizó entre el 8 de mayo de 2022 hasta el 11 de octubre de 2022. Resultados: Se seleccionaron 10 artículos; el promedio de edad fue de 75,3 años; en el 90 % de los artículos predominó el sexo femenino. Con respecto a los programas, el 70 % duró 60 minutos y en el 50% predominó ejercicios principalmente de miembros inferiores, y el 60 % de los artículos usó el Timed Up and Go para evaluar sus programas. La totalidad de los artículos demuestran que el entrenamiento de fuerza redujo el riesgo de caídas a corto plazo. Conclusión: Las principales conclusiones apuntan a un cambio favorable en la prevención de caídas a través del análisis de la fuerza, el equilibrio, la tasa de caídas, la aptitud física y/o el miedo a caer tras realizar entrenamiento de fuerza.

ABSTRACT Introduction: Strength training is associated with positive changes towards healthy aging and quality of life since it prevents injuries, frailty, as well as falls. Objective: The objective of this study was to evaluate the available scientific evidence on the effects of strength training in the prevention of falls in the elderly. Methodology: A search for scientific articles was carried out in the databases: Medline via PubMed, Web of Science (WOS) and Latin American and Caribbean Literature in Health Sciences (LILACS) via the Virtual Health Library (VHL) that meet the the eligibility criteria, the analysis was carried out between the date of May 8, 2022 until October 11, 2022. Results: 10 articles were selected; the average age was 75.3 years; in 90 % of the articles the female sex predominated. With respect to the programs, 70 % lasted 60 minutes and in 50 % exercises mainly of the lower limbs predominated, and 60 % of the articles used Timed Up and Go to evaluate their programs. All the articles show that the training of strength reduced the risk of falls in the short term. Conclusion: The main conclusions point to a favorable change in the prevention of falls through the analysis of strength, balance, rate of falls, physical fitness and/or fear of falling after performing strength training.

Abstract This report analyses the distribution of online attention received by uncited articles of Information Science (InfoSci). Specifically, it aims to understand citation evolution in conjunction with altmetric scores over the years of publication. As a methodology, 45 616 articles -published between 2012 and 2021 in the 'Information Science & Library Science' category in the Web of Science database (WOS)- were collected. The publication year, citations received in each article and their respective altmetric scores were extracted from this sample. Subsequently, descriptive statistical analyses -related to altmetric scores- were conducted based on the publication year. The difference in the proportion of articles without altmetric scores among citation classes was assessed using the Student's T-test. Besides, the Mann-Whitney test was applied to examine whether there were significant differences between citation classes according to the year of publication based on altmetric scores. Results showed that, regardless of citation class and publication year, the most frequent altmetric score among articles is zero. In conclusion, there are altmetric differences between cited and uncited articles; uncited articles tend to receive less altmetric attention than those with citations. Additionally, altmetric attention is not distributed symmetrically, since there is a predominant frequency of zero across all analysed citation classes and years.

Resumen El propósito es analizar la distribución de la atención en línea recibida por artículos no citados en el campo de la Ciencia de la Información (CI). Específicamente, tiene como objetivo comprender la evolución de las citas en conjunto con las puntuaciones altmétricas a lo largo de los años de publicación. Como metodología se recopilaron un total de 45 616 artículos publicados entre 2012 y 2021 en la categoría 'Ciencia de la Información y Biblioteconomía' en la base de datos Web of Science (WOS). De esta recolección se extrajeron el año de publicación, las citas recibidas para cada artículo y sus respectivas puntuaciones altmétricas. Posteriormente, se realizaron análisis estadísticos descriptivos relacionados con las puntuaciones altmétricas en función del año de publicación. La diferencia en la proporción de artículos sin puntuaciones altmétricas entre las clases de citas también se evaluó utilizando la prueba T de Student. Además, se aplicó la prueba de Mann-Whitney para examinar si existen diferencias significativas entre las clases de citas de acuerdo con el año de publicación en función de las puntuaciones altmétricas. Los resultados muestran que, independientemente de la clase de cita y el año de publicación, la puntuación altmétrica más frecuente entre los artículos es cero. Como conclusión, encontramos que existen diferencias altmétricas entre los artículos citados y no citados, siendo los artículos no citados los que tienden a recibir menos atención altmétrica que aquellos con citas. Además, la atención altmétrica no se distribuye simétricamente, pues existe una frecuencia predominante de cero en todas las clases de citas y años analizados.

Resumo O objetivo é analisar a distribuição da atenção online recebida por artigos não citados no campo da Ciência da Informação (CI). Especificamente, tem como propósito compreender a evolução das citações juntamente com as pontuações altmétricas ao longo dos anos de publicação. Na metodologia foram coletados um total de 45 616 artigos publicados entre 2012 e 2021 na categoria 'Ciência da Informação e Biblioteconomia' na base de dados Web of Science (WOS). Dessa coleta, foram extraídos o ano de publicação, as citações recebidas para cada artigo e suas respectivas pontuações altmétricas. Em seguida, foram realizadas análises estatísticas descritivas relacionadas às pontuações altmétricas em função do ano de publicação. A diferença na proporção de artigos sem pontuações altmétricas entre as classes de citações também foi avaliada usando o Teste T de Student. Além disso, o teste de Mann-Whitney foi aplicado para examinar se existem diferenças significativas entre as classes de citações de acordo com o ano de publicação, com base nas pontuações altmétricas. Os resultados mostraram que, independentemente da classe de citação e do ano de publicação, a pontuação altmétrica mais frequente entre os artigos é zero. Em conclusão, existem diferenças altmétricas entre os artigos citados e não citados, sendo os artigos não citados aqueles que tendem a receber menos atenção altmétrica do que os citados. Além disso, a atenção altmétrica não é distribuída simetricamente, com uma frequência predominante de zero em todas as classes de citações e anos analisados.

Resumo Introdução: este estudo traz evidências científicas inéditas para a ampliação do letramento em saúde, como uma ferramenta capaz de aumentar a segurança do paciente através da comunicação eficaz entre os profissionais de saúde e seus pacientes, em especial nos cuidados primários em saúde. Objetivo: mapear evidências sobre o impacto do letramento em saúde na segurança do cuidado de pacientes adultos da atenção primária à saúde. Materiais e método: revisão de escopo de acordo com o método do Instituto Joanna Briggs, em que foram contemplados cuidados, técnicas, protocolos ou métodos de letramento em saúde utilizados para melhorar a assistência primária à saúde. Utilizaram- se as bases Medline (PubMed), Web of Science, Scientific Electronic Library Online (SciELO), Biblioteca Virtual em Saúde, Scopus, Cinahl e Google Acadêmico na literatura cinzenta. Foram incluídos estudos originais disponíveis na íntegra, publicados até janeiro de 2023, em todos os idiomas que englobassem a temática. Dois revisores realizaram a triagem por título e resumo, e três revisores leram os textos completos e extraíram dados dos artigos selecionados, sendo apresentados através de fluxo, tabela e narrativa descritiva. Resultados: foram encontrados 3749 estudos, dos quais 23 foram selecionados. Destes, surgiram as seguintes categorias: “impacto do letramento em saúde no engajamento e desfechos de saúde de usuários da atenção primária à saúde”; “intervenções que contribuem para o letramento em saúde na atenção primária à saúde” e “avaliação das perspectivas de usuários e profissionais quanto ao letramento em saúde”. Conclusões: intervenções para o letramento em saúde com foco nos cuidados primários devem ser estimuladas dentro dos serviços de saúde a fim de promover o cuidado, prevenir agravos e inspirar o processo de transformação da população, impactando diretamente na segurança do paciente.

Resumen Introducción: el estudio aporta evidencias científicas sin precedentes para la expansión de la alfabetización en salud como herramienta capaz de aumentar la seguridad del paciente a través de una comunicación eficaz entre los profesionales de la salud y sus pacientes, especialmente en atención primaria. Objetivo: mapear la evidencia sobre el impacto de la alfabetización en salud en la seguridad de la atención a pacientes adultos en atención primaria. Material y método: revisión exploratoria según el método del Instituto Joanna Briggs, en la que se contemplaron cuidados, técnicas, protocolos o métodos de alfabetización en salud utilizados para mejorar la atención primaria de salud. Se utilizaron las bases de datos Medline (PubMed), Web of Science, Scientific Electronic Library Online (SciELO), Virtual Health Library, Scopus, Cinahl y Google Scholar para la literatura gris. Se incluyeron los estudios originales disponibles en su totalidad, publicados hasta enero de 2023, en todos los idiomas que cubrían el tema. Dos pares seleccionaron por título y resumen, y tres pares leyeron los textos completos y extrajeron los datos de los artículos seleccionados, que se presentaron en flujogramas, tablas y narrativas descriptivas. Resultados: se encontraron 3749 estudios, de los que se seleccionaron 23. De ellos surgieron las siguientes categorías: “impacto de la alfabetización en salud sobre el compromiso y los resultados en salud de los usuarios de atención primaria”; “intervenciones que contribuyen a la alfabetización en salud en atención primaria” y “evaluación de las perspectivas de los usuarios y los profesionales sobre la alfabetización en salud”. Conclusiones: las intervenciones de alfabetización en salud centradas en la atención primaria deben fomentarse en los servicios de salud para promover la atención, prevenir enfermedades e inspirar el proceso de transformación de la población, lo que repercute directamente en la seguridad de los pacientes.

Abstract Introduction: This study provides unprecedented scientific evidence for the expansion of health literacy as a tool capable of increasing patient safety through effective communication between health care professionals and their patients, especially in primary health care. Objective: To map the evidence available regarding the impact of health literacy on care safety for adult patients in primary health care. Materials and methods: This is a scoping review in line with the Joanna Briggs Institute method, which covers care, techniques, protocols, or health literacy methods used to improve primary health care. The Medline (PubMed), Web of Science, Scientific Electronic Library Online (SciELO), Virtual Health Library, Scopus, Cinahl, and Google Scholar databases were used for the gray literature search. Original studies available in full and published until January 2023, in all languages covering the topic, were included. Two reviewers screened them by title and abstract, and three reviewers read the full texts and extracted data from the selected articles presented in flowcharts, tables, and descriptive narratives. Results: A total of 3749 studies were found, of which 23 were selected. From these, the following categories emerged: ‘The impact of health literacy on the engagement and health outcomes of primary health care users;’ ‘Interventions that contribute to health literacy in primary health care;’ and ‘Evaluation of users’ and professionals’ perspectives on health literacy.’ Conclusions: Health literacy interventions focused on primary care should be encouraged within health care services to promote care, prevent illnesses, and inspire the population’s transformation process, with a direct impact on patient safety.

ABSTRACT Purpose: This study aims to evaluate the safety and efficacy of ultrasound-guided balloon dilation compared to non-balloon dilation for percutaneous nephrolithotomy (PCNL). Materials and methods: A systematic review and meta-analysis were conducted by searching PubMed, EMBASE, and the Cochrane Library. Results were filtered using predefined inclusion and exclusion criteria as described and meta-analysis was performed using Review Manager 5.4 software. Results: A total of six studies involving 1189 patients who underwent PCNL were included. The meta-analysis results demonstrated that compared to non-balloon dilation, balloon dilation was associated with reduced haemoglobin drop [mean difference (MD) = -0.26, 95% CI = -0.40 ~ -0.12, P = 0.0002], decreased transfusion rate [odds ratio (OR) = 0.47, 95% CI = 0.24 ~ 0.92, P = 0.03], shorter tract establishment time (MD = -1.30, 95% CI = -1.87 ~ -0.72, P < 0.0001) and shorter operation time (MD = -5.23, 95% CI = -10.19 ~ -0.27, P = 0.04). Conclusions: Overall, ultrasound-guided balloon dilatation offered several advantages in PCNL procedures. It facilitated faster access establishment, as evidenced by shorter access creation time. Additionally, it reduced the risk of kidney injury by minimizing postoperative haemoglobin drop and decreasing the need for transfusions. Moreover, it enhanced the efficiency of surgery by reducing the operation time. However, it is important to note that the quality of some included studies was subpar, as they did not adequately control for confounding factors that may affect the outcomes. Therefore, further research is necessary to validate and strengthen these findings. Purpose ultrasoundguided ultrasound guided nonballoon non PCNL. . (PCNL) methods metaanalysis meta analysis PubMed EMBASE Library 54 5 4 5. software 118 mean MD 0.26, 026 0 26 -0.26 95 0.40 040 40 -0.4 0.12, 012 12 -0.12 0.0002, 00002 0.0002 , 0002 0.0002] odds OR (OR 047 47 0.47 024 24 0.2 092 92 0.92 0.03, 003 0.03 03 0.03] 1.30, 130 1 30 -1.30 1.87 187 87 -1.8 0.72, 072 72 -0.72 0.0001 00001 0001 5.23, 523 23 -5.23 10.19 1019 10 19 -10.1 0.27, 027 27 -0.27 0.04. 004 0.04 04 0.04) Conclusions Overall procedures Additionally transfusions Moreover However subpar outcomes Therefore findings (PCNL 11 0.26 02 2 -0.2 9 0.4 -0. 0.12 01 -0.1 0000 0.000 000 0. 09 0.9 00 0.0 1.30 13 3 -1.3 1.8 18 8 -1. 0.72 07 7 -0.7 5.23 52 -5.2 10.1 101 -10. 0.27 -0 0.1 0.00 1.3 1. -1 0.7 5.2 -5. 10. -10 - -5