This study aimed to isolate, purify and characterize secondary metabolites present in Amburana acreana leaves, native to the state of Rondônia, using classical chromatographic methods and 1D, 2D nuclear magnetic resonance spectroscopy. From the hydroethanolic leaves extract of A. acreana, p-hydroxybenzoic acid, vanillic acid, coumarin, campesterol 3-β-D-glucoside and amburoside B, all known compounds, were identified. To the best of our knowledge, this is the first report of isolation and chemical characterization of secondary metabolites in A. acreana. In addition, in vitro assays indicated that amburoside B does not have inhibitory potential on the growth of gram-negative bacteria. The presence of these compounds suggests that, thus far, amburosides (A and B) could be chemotaxonomic markers of the genus Amburana. isolate Rondônia 1D D spectroscopy A phydroxybenzoic p hydroxybenzoic acid coumarin 3βDglucoside βDglucoside 3 β glucoside identified knowledge addition gramnegative gram negative bacteria far

Parthenolide (PTN) is a secondary metabolite of the plant Tanacetum parthenium (L.) Schulz Bip. and is considered the chemical marker of this species. This sesquiterpene lactone (germacrene skeleton) has been described as responsible for the biological activity of the leaf extract. In addition, several studies in the literature have demonstrated its antiparasitic and antineoplastic activity. However, there is a need for knowledge of other safety parameters, such as pharmacokinetic, pharmacodynamic and toxicity evaluations. Therefore, in this investigation, the in vitro metabolism of parthenolide was performed with rat liver microsomes and biomimetic metabolism (such as cytochrome P-450 system) using organometallic catalysts. The biomimetic procedure was validated since the major compound of biomimetic oxidative reaction with meta-chloroperbenzoic acid catalyzed by metalloporphyrin 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin iron(III) chloride was also observed with rat liver microsomes. Previous chemoenzymatic synthesis studies of PTN afforded the same epoxide formation, this major oxidative compound was isolated and fully characterized as (1 R,10R)-epoxyparthenolide based on experimental and theoretical calculations of infrared (IR) and vibrational circular dichroism (VCD) data at the B3PW91/6-311G. Furthermore, for the first time, this metabolite was evaluated for trypanocidal and leishmanicidal activity. The mean inhibitory concentration (IC50) values were lower for PTN than its metabolite and showed significant cytotoxic effects for both parasites. This finding holds promise for addressing neglected diseases. (PTN L. L (L. Bip species germacrene skeleton extract addition However parameters pharmacokinetic evaluations Therefore investigation P450 P 450 P-45 system catalysts metachloroperbenzoic meta chloroperbenzoic 5,10,15,20tetrakispentafluorophenylporphyrin 5101520tetrakispentafluorophenylporphyrin tetrakispentafluorophenylporphyrin 5,10,15,20 tetrakis pentafluorophenyl porphyrin 5 10 15 20 ironIII iron III iron(III formation 1 ( R,10Repoxyparthenolide R10Repoxyparthenolide RRepoxyparthenolide R,10R epoxyparthenolide R 10R IR (IR VCD (VCD B3PW91/6311G. B3PW916311G BPWG B3PW91/6 311G. B3PW91 6 311G B PW G B3PW91/6-311G Furthermore time IC50 IC (IC50 parasites diseases (L P45 45 P-4 20tetrakispentafluorophenylporphyrin 5101520 5,10,15,2 2 10Repoxyparthenolide Repoxyparthenolide R10R RR 6311G B3PW91/6311G B3PW916 BPW B3PW91/ B3PW9 IC5 (IC5 P4 4 P- 510152 5,10,15, B3PW (IC 51015 5,10,15 5101 5,10,1 510 5,10, 51 5,10 5,1 5,

Compared to other species, components of Combretum lanceolatum are still with few data reported in the literature. This work describes the compounds identification, antioxidant and antimicrobial activities of C. lanceolatum twigs. Ethanolic extract (EECLT) from C. lanceolatum twigs was submitted to partition obtaining: hexane (HF), diethyl ether (EEF), ethyl acetate (EAF) and hydromethanolic (HMF) fractions. They were analyzed by gas chromatography-mass spectrometry, high performance liquid chromatography coupled to mass spectrometry and direct insertion mass spectrometry and evaluated for antioxidant assay (2,2-diphenyl-1-picrylhydrazyl (DPPH) method) and antimicrobial assay. Fifty-seven compounds were identified in the fractions. In antioxidant assay, EECLT and EAF demonstrated good antioxidant potential (half maximal effective concentration (EC50): 57.9 and 45.4 µg mL–1, respectively), better than the positive control butylated hydroxytoluene (BHT) (EC50: 69.34 µg mL–1). For antimicrobial assay, all fractions presented promising minimal inhibitory concentration (MIC). EECLT presented the best values against Staphylococcus aureus (125 µg mL–1) and Escherichia coli (62.5 µg mL–1) and better than the positive control fluconazole (8 and 16 µg mL–1) against Candida albicans (3.9 µg mL–1) and Candida krusei (15.6 µg mL–1) strains. This study presents relevant chemical and biological information about C. lanceloatum expanding the knowledge of Brazilian flora. species literature identification C (EECLT obtaining HF, HF , (HF) EEF, EEF (EEF) (EAF HMF (HMF chromatographymass 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl 1 picrylhydrazyl 2 DPPH (DPPH method Fiftyseven Fifty seven half EC50 EC (EC50) 579 57 9 57. 454 45 4 45. mL1 mL mL–1 respectively, respectively respectively) BHT (BHT (EC50 6934 69 34 69.3 mL–1. . MIC. MIC (MIC) 125 (12 62.5 625 62 5 (62. 8 ( 3.9 39 3 (3. 15.6 156 15 6 (15. strains flora (HF (EEF 2diphenyl1picrylhydrazyl 22 2, EC5 mL– (EC5 693 69. (MIC 12 (1 62. (62 3. (3 15. (15 (EC (6

RESUMO: O ensino de anatomia vem se modificando ao longo dos anos, introduzindo métodos tecnológicos, principalmente após o período pandêmico. Questiona-se o uso exclusivo da tecnologia em comparação aos métodos tradicionais de dissecação e aulas teóricas presenciais no que diz respeito à aquisição de conhecimento. Este artigo analisou a percepção de conhecimento de alunos de diversos semestres do curso de Medicina Veterinária, comparando alunos que tiveram aulas apenas online com aqueles que tiveram aulas presenciais de Anatomia Descritiva dos Animais Domésticos. Para tanto, questões foram enviadas por meio de formulário, com preenchimento voluntário e anônimo, e posteriormente analisadas estatisticamente. Os resultados indicam que 11,5% dos alunos que cursaram a disciplina remotamente falharam na aplicação dos conhecimentos em outras disciplinas, enquanto nenhum aluno do ensino presencial relatou o mesmo. A maioria dos alunos, tanto dos grupos remotos quanto dos presenciais, lembram-se do assunto, mas revisam o conteúdo com frequência. Em relação ao conhecimento teórico, o grupo online (80,8%) compreendeu melhor à medida que o curso avançava, comparado a 59,6% do grupo presencial. A ligação entre Anatomia e outras disciplinas foi mais destacada pelo grupo presencial (30,8%) em comparação ao online (15,4%). Ambos os grupos concordam que o contacto físico com peças anatômicas é essencial, mas alguns consideram possível ter um primeiro contacto com imagens ou fotografias 3D. Baseado nesse estudo preliminar, conclui-se que as interações iniciais com a área de Anatomia devem incluir técnicas pedagógicas diversificadas com comunicação empática. A utilização de recursos tecnológicos modernos é um aliado do processo de ensino-aprendizagem, e após a abstração dos conteúdos é possível o uso singular da tecnologia na manutenção e atualização do conhecimento anatômico. RESUMO anos pandêmico Questionase Questiona Veterinária Domésticos formulário anônimo estatisticamente 115 11 5 11,5 mesmo lembramse lembram assunto frequência teórico 80,8% 808 80 8 (80,8% avançava 596 59 6 59,6 30,8% 308 30 (30,8% 15,4%. 154 15,4% . 15 4 (15,4%) essencial 3D D preliminar concluise conclui empática ensinoaprendizagem, ensinoaprendizagem aprendizagem, aprendizagem ensino-aprendizagem anatômico 1 11, 80,8 (80,8 59, 30,8 3 (30,8 15,4 (15,4% 80, (80, 30, (30, 15, (15,4 (80 (30 (15, (8 (3 (15 ( (1

ABSTRACT: Anatomy teaching has been changing over the years, introducing technological methods especially after the pandemic period. An ongoing debate revolves around whether exclusive reliance on technology for anatomy classes, as opposed to traditional methods and face-to-face instruction, enhances knowledge acquisition. This study analyzed the knowledge perception of students from various semesters throughout the Veterinary Medicine course, comparing students who only had online classes with those who had face-to-face classes in Gross Anatomy of Domestic Animals. For this purpose, a questionnaire was distributed for voluntary and anonymous completion, and the responses were subsequently analyzed statistically. The results indicated that 11.5% of the students who took Anatomy remotely failed to apply the knowledge in other subjects, while no face-to-face learning student reported the same. Most students, both remote and face-to-face groups, remember the subject but review the content frequently. Regarding theoretical knowledge, the online group (80.8%) understood better as the course progressed, compared to 59.6% of the face-to-face group. The connection between Anatomy and other subjects was more highlighted by the face-to-face group (30.8%) compared to the online group (15.4%). Both groups agree that physical contact with anatomical specimens is essential; however, some believe that initial exposure through 3D images or photographs is feasible. We concluded based on this preliminary study that the initial interactions with the Anatomy field should include diversified pedagogical techniques with empathetic communication. The use of modern technological resources are allies in the teaching-learning process. Furthermore, after abstracting the contents, technology alone can effectively maintain and update anatomical knowledge. ABSTRACT years period facetoface face instruction acquisition Animals purpose completion statistically 115 11 5 11.5 same frequently 80.8% 808 80 8 (80.8% progressed 596 59 6 59.6 30.8% 308 30 (30.8% 15.4%. 154 15.4% . 15 4 (15.4%) essential however D feasible communication teachinglearning process Furthermore contents 1 11. 80.8 (80.8 59. 30.8 3 (30.8 15.4 (15.4% 80. (80. 30. (30. 15. (15.4 (80 (30 (15. (8 (3 (15 ( (1

The inhibition of the fatty acid amide hydrolase (FAAH), an endocannabinoid system component, emerged as a potentially new therapeutic target for a range of clinical disorders such as acute and chronic pain. Some α-ketoheterocycle derivatives demonstrated interesting analgesic and anti-inflammatory activities in vitro. Ligand-Based Drug Design techniques such as knowledge graph convolutional networks (kGCN) and hologram quantitative structure-activity relationship (HQSAR) using α-ketoheterocycle derivatives from five different datasets were generated to discover the relation between the chemical structures and the inhibition activity. Meanwhile, structure-based drug design simulations as interaction fields (MIF), molecular docking, and ligand sites studies (LSI) from FAAH were performed using Autogrid software and FTmap/FTsite servers. The results of both studies were merged to propose predictive models. The resulting kGCN model demonstrated adequate accuracy area under the curve by receiver operating characteristic (AUC-ROC 0.7922). From contribution maps of the Ligand-Based Drug Design (LBDD) models and the generated probes using MIF and LSI, it was observed that the oxazole ring, the ketone group, and the apolar chain present in the structures of the inhibitors are important, besides the evidence of the Cys269 and Val270 residues importance for the potential interaction, confirmed by carried docking studies. These fragments and structural information can be used to carry out new FAAH potential inhibitors studies and report kGCN as an accurate classification technique. FAAH, , (FAAH) component pain αketoheterocycle α ketoheterocycle antiinflammatory anti inflammatory vitro LigandBased Ligand Based (kGCN structureactivity structure activity HQSAR (HQSAR Meanwhile structurebased based MIF, (MIF) LSI (LSI FTmapFTsite FTmap FTsite servers AUCROC AUC ROC 0.7922. 07922 0.7922 . 0 7922 0.7922) LBDD (LBDD ring group important Cys Cys26 Val Val27 technique (FAAH (MIF 0792 0.792 792 Cys2 Val2 079 0.79 79 07 0.7 7 0.

Lantana caatingensis Moldenke (Verbenaceae) is an endemic plant from northeastern Brazil. However, its chemical composition is almost unknown. This study aimed to characterize the chemical compounds found in L. caatingensis and investigate the antileishmanial potential of its hydroalcoholic extract and polar fractions. Compounds present in the hydroalcoholic extract obtained from L. caatingensis leaves and its polar fractions (ethyl acetate and methanolic) were analyzed by liquid chromatography with a photodiode-array detector coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. An antileishmanial assay was performed in a 96-well plate against Leishmania major promastigotes using resazurin on a plate spectrophotometer and the results were expressed as percentage of growth inhibition. Nine compounds were determined in the investigated extract and fractions, classified as flavonoids, flavonoid C-glycosides and phenylethanoid glycosides. The antileishmanial activity revealed that the hydroalcoholic extract and the ethyl acetate fraction were active against L. major promastigotes with inhibitory concentration of 71.78 and 26.86 µg mL-1, respectively, while the methanolic fraction was inactive (478.40 µg mL-1). This is the first report on the chemical composition and antileishmanial activity of L. caatingensis extracts. These results contribute to further knowledge of species belonging to the Lantana genus. Verbenaceae (Verbenaceae Brazil However unknown L photodiodearray photodiode array timeofflight time flight spectrometry 96well well 96 inhibition flavonoids Cglycosides C glycosides 7178 71 78 71.7 2686 26 86 26.8 mL1, mL1 mL 1, 1 mL-1 respectively 478.40 47840 478 40 (478.4 mL1. . mL-1) extracts genus 9 717 7 71. 268 2 8 26. mL- 478.4 4784 47 4 (478. 478. (478 (47 (4 (

Palicourea tomentosa (Aubl.) Borhidi (Rubiaceae, Palicoureeae), earlier classified as Psychotria poeppigiana Müll. Arg., is used in folk medicine for a variety of diseases. Biological studies on the plant describes their vasorelaxant, antiplasmodial, antitumoural and anticholinesterase activities. To expand the knowledge on the chemical and biological potential of this species, in this work, phytochemical and dereplication studies, as well as antimicrobial and anticholinesterase evaluation of Palicourea tomentosa were carried out. Phytochemical investigation deals with the isolation of lutein (1), a mixture of dehydrovomifoliol (2) and megastigma-4,7-dien-3-one (3), loliolide (4), 5,13-epoxy-9-hydroxy-megastigma-7-en,3-one (5), vomifoliol (6), asperuloside (7), 3-O-p-coumaroylquinic acid (8), and a mixture of the pyrrolizidinoindoline alkaloids hodgkinsine (9), chimonanthine (10) and psychotriasine (11). The ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC HRMS/MS) based on molecular networking dereplication of dichloromethane fraction led to putative identification of other two megastigmanes, one terpene lactone and three carotenoids, besides seven triterpenes and four indole alkaloids. The dichloromethane, ethyl acetate and hydromethanol fractions of P. tomentosa were able to inhibit Candida albicans with minimum inhibitory concentrations (MICs) of 125, 250 and 125 µg mL-1, respectively. The methanol crude extract, dichloromethane and alkaloid fractions inhibited selectively the butyrilcholinesterase (BuChE) at percentages of 63.09, 60.39 and 56.22%, respectively. Aubl. Aubl (Aubl. Rubiaceae, Rubiaceae (Rubiaceae Palicoureeae, Palicoureeae , Palicoureeae) Müll Arg Arg. diseases vasorelaxant antiplasmodial activities species work out 1, 1 (1) 2 (2 megastigma4,7dien3one megastigma47dien3one megastigmadienone megastigma 4,7 dien 3 4 7 3, (3) 4, (4) 5,13epoxy9hydroxymegastigma7en,3one 513epoxy9hydroxymegastigma7en3one epoxyhydroxymegastigmaenone 5,13 epoxy 9 hydroxy en,3 5 13 en 5, (5) 6, 6 (6) 7, (7) 3Opcoumaroylquinic Opcoumaroylquinic O p coumaroylquinic 8, 8 (8) 9, (9) 10 (10 11. 11 . (11) ultrahigh ultra high highresolution resolution UHPLC HRMS/MS HRMSMS HRMS MS megastigmanes carotenoids P MICs (MICs 25 12 mL1, mL1 mL mL-1 respectively extract BuChE (BuChE 6309 63 09 63.09 6039 60 39 60.3 5622 56 22 56.22% (Aubl (1 ( megastigma4 7dien3one 47 (3 (4 13epoxy9hydroxymegastigma7en 3one hydroxymegastigma 513 5,1 en3 en, (5 (6 (7 (8 (9 (11 mL- 630 0 63.0 603 60. 562 56.22 dienone epoxyhydroxymegastigmaen 51 63. 56.2 56.

RESUMO Vários estudos têm vinculado diferentes outcomes organizacionais como antecedentes às capacidades dinâmicas, sendo que se destacam o empreendedorismo, o dinamismo ambiental, os recursos, a gestão do conhecimento, a aprendizagem organizacional e o planejamento estratégico. O presente estudo tem por objetivo avaliar de forma completa, considerando todas as dimensões conceituais, como se relacionam o modelo das alavancas de controle estratégico e as capacidades dinâmicas, considerando o perfil dos empregados da ITAIPU Binacional. Os dados foram coletados por meio de um survey e as hipóteses avaliadas com o auxílio da modelagem de equações estruturais, empregando-se o método de estimação por mínimos quadrados parciais. Os resultados obtidos validaram a hipótese central de que as alavancas de controle influenciam positivamente a presença das capacidades dinâmicas, além de uma das hipóteses complementares de que o sistema interativo influencia positivamente a presença da capacidade de sentir as oportunidades. As alavancas de controle estratégico podem ser tratadas agora pelas organizações como possíveis fontes de capacidades dinâmicas. dinâmicas empreendedorismo ambiental recursos conhecimento completa conceituais Binacional estruturais empregandose empregando parciais oportunidades

ABSTRACT Several studies have thus far linked diverse organizational outcomes as antecedents to dynamic capabilities, with an emphasis on entrepreneurship, environmental dynamism, resources, knowledge management, organizational learning, and strategic planning. This study aims to fully assess how the model of strategic levers of control and dynamic capabilities framework are related, considering all conceptual dimensions and the profile of ITAIPU Binacional employees. The data was collected through a survey, and the hypotheses evaluated with the assistance of structural equation modelling, using the partial least squares estimation method. The findings validated the central hypothesis, that the levers of control do positively influence the presence of the dynamic capabilities, in addition to one other complementary hypothesis- that the interactive system also positively influences the ability to sense opportunities. The strategic levers of control can now be treated by organizations as possible sources of dynamic capabilities. entrepreneurship dynamism resources management learning planning related employees survey modelling method hypothesis opportunities

RESUMO: Os estudos visando o melhoramento de lúpulo (Humulus lupulus) no Brasil são recentes e buscam estabelecer a autossuficiência da produção. O conhecimento da variabilidade dos genótipos disponíveis no país é de fundamental importância para o desenvolvimento de um programa de melhoramento de lúpulo. O objetivo do trabalho foi identificar genitores de lúpulo com potencial agronômico e cervejeiro para o Planalto Catarinense, Brasil. Foi utilizado o delineamento em blocos casualizados em esquema fatorial 3x4 com 12 tratamentos: Fator 1: três anos de cultivo (2019, 2020 e 2021) e combinado com o fator 2: quatro genótipos (Cascade, Chinook, Columbus e Hallertau). Os caracteres avaliados foram a massa fresca de plantas (MFP, g), massa verde de cones (MTV, g), a massa seca de cones (MSC, g), os teores de alfa-ácidos (ALFA, %) e a produção (PROD, g per planta). O genótipo Hallertauer demonstrou melhor desempenho e comportamento diferenciado para os caracteres de massa fresca de plantas, massa seca de cones e produção, quando comparado aos demais. Assim, a partir destes resultados observou-se que, existe variação disponível ao melhoramento genético do lúpulo para esses caracteres, fator que permitirá obter ganhos produtivos no desenvolvimento de novas cultivares, a partir deste genótipo promissor. RESUMO Humulus lupulus Catarinense x 3x 1 tratamentos 2019, 2019 (2019 202 2021 2 Cascade, Cascade (Cascade Chinook Hallertau. Hallertau . Hallertau) MFP, MFP (MFP g, , g) MTV, MTV (MTV MSC, MSC (MSC alfaácidos alfa ácidos ALFA, ALFA (ALFA % PROD, PROD (PROD planta. planta planta) demais Assim observouse observou se cultivares promissor 201 (201 20 (20 (2 (

ABSTRACT: Studies on the improvement of hops (Humulus lupulus) in Brazil are recent and seek to establish self-sufficiency in production. Knowledge of the variability of genotypes available in the country is of fundamental importance for the development of a hop improvement program. The objective of the research was to characterize and identify hop parents with agronomic and brewing potential for the Planalto Catarinense region, Brazil. The randomized block design arranged in a 3x4 factorial scheme was used with 12 treatments: (Factor 1: three years of cultivation (2019, 2020 and 2021) and combined with factor: four genotypes (Cascade, Chinook, Columbus and Hallertau). The characters evaluated were fresh mass of plants (MFP, g), green mass of cones (MTV, g), dry mass of cones (MSC, g), alpha-acid content (ALFA, %) and production (PROD, g per plant). The Hallertauer genotype showed better performance and differentiated behavior for the characters of fresh mass of plants, dry mass of cones and production, when compared to the others. Thus, from these results it was observed that there is variation available for the genetic improvement of hops for these characters, a factor that will allow obtaining productive gains in the development of new cultivars, based on this promising genotype. ABSTRACT Humulus lupulus selfsufficiency self sufficiency program region x 3x 1 treatments Factor 2019, 2019 (2019 202 2021 Cascade, Cascade (Cascade Chinook Hallertau. Hallertau . Hallertau) MFP, MFP (MFP g, , g) MTV, MTV (MTV MSC, MSC (MSC alphaacid alpha acid ALFA, ALFA (ALFA % PROD, PROD (PROD plant. plant plant) others Thus cultivars 201 (201 20 (20 2 (2 (

Résumé Quel est le rôle de la Justice Électorale au Brésil ? Cette question a guidé de nombreux travaux sur la période démocratique actuelle. Cependant, la connaissance de la phase initiale de la Justice Électorale est presque inexistante. Cet article constitue une tentative préliminaire visant à élucider les “premiers pas” de la Justice Électorale dans la conduite de l’élection de 1933. En partant d’un cadre analytique centré sur quatre aspects - l’organisation de l’élection, l’impartialité, l’indépendance et l’élaboration des règles -, et grâce à une collecte de données inédites dans les journaux et les sources officielles, l’étude montre qu’à l’époque, la Justice Électorale présentait 1) un fort engagement dans les aspects organisationnels, bien qu’elle agissait dans des conditions de 2) partialité relative, surtout au niveau administratif local. Je conclus en proposant un programme de recherche pour les années à venir dans lequel le rôle de la Justice Électorale dans la conduite des élections est considéré comme l’axe central pour problématiser la démocratisation au Brésil au-delà des dimensions classiques (suffrage, vote secret, compétition politique) discutées dans la littérature. actuelle Cependant inexistante premiers pas lélection l élection 1933 dun d lorganisation organisation lélection, élection, limpartialité, limpartialité impartialité, impartialité l’impartialité lindépendance indépendance lélaboration élaboration , officielles létude étude quà qu lépoque, lépoque époque, époque l’époque 1 organisationnels quelle elle 2 relative local laxe axe audelà delà suffrage, suffrage (suffrage secret politique littérature 193 19

Resumo Qual o papel da Justiça Eleitoral na condução das eleições? Esta pergunta orientou vários trabalhos sobre o período democrático atual. Entretanto, o conhecimento sobre a fase inicial da Justiça Eleitoral é quase que inexistente. Este artigo constitui uma tentativa preliminar de elucidar os “primeiros passos” da Justiça Eleitoral na condução da eleição de 1933. Partindo de um arcabouço analítico centrado em quatro aspectos – organização da eleição, imparcialidade, independência e rule-making –, e por meio de um levantamento de dados inéditos em jornais e fontes oficiais, o estudo revela que em 1932 a Justiça Eleitoral apresentava 1) um elevado comprometimento nos aspectos organizacionais, ainda que atuasse em condições de 2) relativa parcialidade, sobretudo no âmbito administrativo local. O artigo conclui propondo que o tema da democratização no Brasil deva ir além das dimensões clássicas discutidas pela literatura (sufrágio, voto secreto, competição política) e passe a incorporar o papel da Justiça Eleitoral, contribuindo para a construção de uma agenda de pesquisa em torno deste ramo especializado do Poder Judiciário. eleições atual Entretanto inexistente primeiros passos 1933 imparcialidade rulemaking rule making oficiais 193 1 organizacionais 2 parcialidade local sufrágio, sufrágio (sufrágio secreto política Judiciário 19

Resumen ¿Cuál es el papel de la Justicia Electoral en Brasil? Esta cuestión ha guiado varios trabajos sobre el actual periodo democrático. Sin embargo, los conocimientos sobre la fase inicial de la justicia electoral son casi inexistentes. Este artículo es un intento preliminar de dilucidar los “primeros pasos” de la Justicia Electoral en la conducción de las elecciones de 1933. A partir de un marco analítico centrado en cuatro aspectos – organización de la elección, imparcialidad, independencia y elaboración de normas – y mediante un estudio de datos inéditos procedentes de periódicos y fuentes oficiales, el estudio demuestra que en aquella época la Justicia Electoral estaba 1) muy comprometida con sus aspectos organizativos, aunque actuaba en condiciones de 2) relativa parcialidad, especialmente en el ámbito administrativo local. Concluyo proponiendo una agenda de investigación para los próximos años en la que sea considerado el papel de la Justicia Electoral en la conducción de las elecciones como un eje central para problematizar la democratización en Brasil más allá de las dimensiones clásicas (sufragio, voto secreto, competencia política) discutidas en la literatura. Cuál democrático embargo inexistentes primeros pasos 1933 elección imparcialidad oficiales 1 organizativos 2 parcialidad local sufragio, sufragio (sufragio secreto política literatura 193 19

Abstract What is the role of the Electoral Justice in Brazil? This question has guided several studies on the current democratic period. However, there is almost no knowledge about the initial phase of the Electoral Justice. This article is a preliminary attempt to elucidate the “first steps” of the Electoral Justice in the conduct of the 1933 election. Based on an analytical framework centered on four aspects - organization of the election, impartiality, independence and rule-making - and through a survey of unpublished data from newspapers and official sources, the study shows that at the time the Electoral Justice was highly committed to organizational aspects, even though it acted in conditions of relative partiality, especially at the local administrative level. I conclude by proposing a research agenda for the coming years in which the role of the Electoral Justice in the conduct of elections is considered as a central axis for problematizing democratization in Brazil beyond the classic dimensions (suffrage, secret ballot, political competition) discussed in the literature. period However first steps 193 election impartiality rulemaking rule making sources partiality level suffrage, suffrage (suffrage ballot competition literature 19 1

ABSTRACT Knowledge of the complicated correlation between meteorological variables and crop yield is crucial for food security and agricultural sustainability. This study aimed to investigate how incident solar radiation has affected crop production in the Gadarif region of Sudan over the last 41 years. Using a predictive framework, trends in annual incident solar radiation and temporal variations during sorghum and sesame growing seasons were examined and machine learning (ML) with Extreme Gradient Boosting (XGBoost), Boosted Regression Forest (BRF), and K-Nearest Neighbors (K-NN) was used to predict crop yield. Significant relationships between incident solar radiation indicators and crop yields were identified via detrending approaches and correlation analyses. Results indicate a significant inverse correlation between solar radiation and sorghum yield, and a positive correlation between sesame yield and solar radiation. For both sorghum and sesame yield, K-NN was the most accurate model, demonstrating the significance of incident solar radiation and temperature in predicting crop yield. These findings highlight the potential of ML to improve agricultural forecasting models and inform adaptive agricultural practices in the region. In general, this study provides valuable insights into the dynamic relationship between incident solar radiation and crop yield, emphasizing the importance of considering meteorological factors in agricultural planning and management. sustainability 4 years framework (ML XGBoost, XGBoost , (XGBoost) BRF, BRF (BRF) KNearest K Nearest KNN NN (K-NN analyses model general management (XGBoost (BRF

RESUMO O conhecimento da complicada correlação entre as variáveis meteorológicas e o rendimento das culturas é crucial para a segurança alimentar e a sustentabilidade agrícola. Este estudo está centrado na investigação de como a radiação solar incidente afetou a produção agrícola na região de Gadarif, no Sudão, nos últimos quarenta anos. Usando uma estrutura preditiva, a pesquisa avalia tendências recentes na radiação solar incidente anual, examina variações temporais durante as estações de cultivo de sorgo e gergelim e utiliza técnicas de aprendizado de máquina para prever o rendimento das culturas. Além disso, ML, incluindo Extreme Gradient Boosting (XGBoost), Boosted Regression Forest (BRF) e K-Nearest Neighbours (K-NN), foram empregados para previsão de rendimento. Através de abordagens de redução de tendências e análises de correlação, foram identificadas relações significativas entre os indicadores de radiação solar incidente e o rendimento das culturas. Os resultados indicam uma correlação inversa substancial entre a radiação solar e a produção de sorgo, enquanto a produção de gergelim demonstra uma correlação positiva com a radiação solar. Tanto para o rendimento do sorgo como do gergelim, o K-NN surge como o modelo mais preciso, mostrando a importância da radiação solar incidente e da temperatura na previsão do rendimento das culturas. Estas descobertas destacam o potencial da aprendizagem de máquina para melhorar os modelos de previsão agrícola e informar as práticas agrícolas adaptativas na região. Em geral, este estudo fornece informações valiosas sobre a relação dinâmica entre a radiação solar incidente e o rendimento das culturas, enfatizando a importância de considerar fatores meteorológicos no planeamento e gestão agrícola. Gadarif Sudão anos preditiva anual disso ML XGBoost, XGBoost , (XGBoost) BRF (BRF KNearest K Nearest KNN, KNN NN (K-NN) preciso geral (XGBoost (K-NN

Resumen Marco contextual: La alfabetización en salud (AS) es la capacidad de una persona para obtener y traducir información con el fin de mantener y mejorar su salud. Objetivo: Caracterizar el nivel de AS de las personas ingresadas en un hospital oncológico; evaluar la fiabilidad del instrumento European Health Literacy Survey in Portuguese (HLS-EU-PT). Metodología: Estudio transversal, cuantitativo, descriptivo y metodológico. Muestra de 188 personas ingresadas en un servicio de cirugía oncológica entre mayo y septiembre de 2020, se recogieron datos mediante un formulario de caracterización sociodemográfica y de salud, y una herramienta de evaluación de AS. Resultados: El HLS-EU-PT mostró un alto nivel de consistencia interna. Todos los dominios y niveles de procesamiento del instrumento correlacionaron positivamente entre sí. Por término medio, los participantes tienen un nivel problemático de AS. Conclusión: Los resultados indican la necesidad de una mayor inversión en formación en AS. Son necesarios más estudios en esta y otras poblaciones, y en entornos sanitarios para orientar la práctica asistencial hacia una respuesta eficaz a los problemas de salud.

Resumo Enquadramento: A literacia em saúde (LS) é a capacidade da pessoa obter e traduzir informações a fim de manter e melhorar a saúde. Objetivo: Caracterizar o nível de LS da pessoa internada num hospital oncológico; avaliar a fiabilidade do instrumento European Health Literacy Survey in Portuguese (HLS-EU-PT). Metodologia: Estudo transversal, quantitativo, descritivo e metodológico. Amostra de 188 pessoas internados num serviço de cirurgia oncológica entre maio e setembro de 2020, os dados foram colhidos através de formulário de caracterização sociodemográfica, de saúde e instrumento de avaliação da LS. Resultados: O HLS-EU-PT apresentou elevado nível de consistência interna. Todos os domínios e níveis de processamento do instrumento se correlacionam positivamente entre si. Os participantes apresentam em média um nível problemático de LS. Conclusão: Os resultados indiciam a necessidade de um maior investimento na capacitação da LS. São necessários mais estudos nesta e noutras populações e contextos de prestação de cuidados de saúde, de forma a direcionar a prática de cuidados na resposta eficaz aos problemas de saúde.

Abstract Background: Health literacy (HL) is the ability of an individual to obtain and translate information in order to maintain and improve their health. Objective: To characterize the level of HL of patients admitted to an oncology hospital and assess the reliability of the Portuguese version of the European Health Literacy Survey (HLS-EU-PT). Methodology: Cross-sectional, quantitative, descriptive, and methodological study. Sample of 188 patients admitted to a surgical oncology unit between May and September 2020. Data were collected through a sociodemographic and health characterization form and a HL assessment tool. Results: The HLS-EU-PT had a high level of internal consistency. All domains and information-processing levels correlated positively with each other. Participants had on average a problematic level of HL. Conclusion: The results indicate the need for greater investment in HL training. Further studies are needed in this population and in other populations and healthcare settings to provide an effective response to health problems.

Resumen Marco contextual: La implantación de la Práctica Basada en la Evidencia (PBE) es esencial para la calidad de los cuidados de enfermería. Las acciones emprendidas por los líderes formales son esenciales para implantar la PBE, y es fundamental conocer sus percepciones. Objetivo: Conocer las percepciones de los líderes formales de enfermería sobre la PBE. Metodología: Estudio exploratorio descriptivo con enfoque cualitativo. Se realizaron entrevistas semiestructuradas a 17 líderes de tres hospitales portugueses. Los datos se analizaron mediante análisis de contenido y el programa MAXQDA Analytic Pro 2022. Se garantizaron los presupuestos éticos. Resultados: Surgieron dos temas con sus respectivas categorías − Conocimiento sobre la PBE (Concepto de la PBE, Impacto de la PBE en los resultados sanitarios y Autopercepción del conocimiento sobre la PBE); Papel en la aplicación de la PBE (comportamientos y características). Conclusión: Los líderes describieron su percepción del concepto de PBE y la relación del Impacto de la PBE con los resultados sanitarios, la necesidad de conocimientos y su inversión formativa, así como su papel en este proceso. Los futuros programas de formación deberían aplicarse en este ámbito.

Resumo Enquadramento: A implementação da Prática Baseada na Evidência (PBE) é crucial para a qualidade dos cuidados de enfermagem. As ações desenvolvidas pelos líderes formais são essenciais para implementar a PBE, tornando-se determinante conhecer as suas perceções. Objetivo: Conhecer as perceções de líderes formais de enfermagem sobre a PBE. Metodologia: Estudo descritivo exploratório com abordagem qualitativa. Foram realizadas entrevistas semiestruturadas a 17 líderes de três hospitais portugueses. Os dados foram analisados através de análise de conteúdo e do software MAXQDA Analytics Pro 2022. Salvaguardados os pressupostos éticos. Resultados: Emergiram dois temas com respetivas categorias − Conhecimento sobre PBE (Conceito de PBE, Impacto da PBE nos resultados em saúde e Autoperceção do conhecimento sobre PBE); Papel na implementação da PBE (comportamentos e caraterísticas). Conclusão: Os líderes descreveram a sua perceção sobre o Conceito de PBE e a relação do Impacto da PBE com resultados em saúde, a necessidade de conhecimento e o seu investimento formativo, bem como o seu papel neste processo. Futuros programas formativos deverão ser implementados nesta área.

Abstract Background: The implementation of Evidence-Based Practice (EBP) is critical to the quality of nursing care. Formal leaders play a crucial role in developing interventions to implement EBP, so it is important to understand their perceptions. Objective: To examine formal nurse leaders’ perceptions of EBP. Methodology: Descriptive exploratory study with a qualitative approach. Semi-structured interviews were conducted with 17 leaders from three Portuguese hospitals. Data were analyzed using content analysis and MAXQDA Analytics Pro 2022 software. All ethical principles were observed. Results: Two themes and their categories emerged − Knowledge of EBP (Concept of EBP, Impact of EBP on health outcomes, and Self-perception of the knowledge about EBP) and Role in EBP implementation (behaviors and characteristics). Conclusion: The leaders described their perception of the concept of EBP and the association between the impact of EBP and health outcomes, the need for knowledge, and the investment in training, as well as their role in this process. Future training programs should be implemented in this area.

Resumen Marco contextual: Las ambulancias de soporte vital inmediato (SVI) permiten al personal de enfermería intervenir en un contexto prehospitalario, con el apoyo de sus conocimientos técnico-científicos y de complejos protocolos de actuación y regulación médica a través de la telemedicina. Objetivo: Analizar las aportaciones de la intervención del personal de enfermería del SVI en la evolución del estado clínico de la persona en situación crítica (PSC). Metodología: Estudio cuantitativo, descriptivo-correlacional, retrospectivo, realizado en centros de SVI del norte de Portugal. Se analizaron 574 historias clínicas electrónicas entre el 1 de noviembre y el 31 de diciembre de 2019, correspondientes al mismo número de personas evaluadas. Se utilizó la escala National Early Warning Score (NEWS) para evaluar la evolución clínica de la PSC. Resultados: Se observó una evolución positiva en el score NEWS de la PSC, tras la intervención del personal de enfermería del SVI (M = 4,43 ± 3,901 vs 3,34 ± 3,329; sig < 0,001). Por el contrario, el riesgo clínico disminuyó significativamente tras la intervención del personal de enfermería. Conclusión: Se demostró la relevancia de la intervención del personal de enfermería del SVI en el contexto prehospitalario, como garantía de seguridad, calidad y mejora continua en la atención a la PSC.

Resumo Enquadramento: As ambulâncias de suporte imediato de vida (SIV) possibilitam ao enfermeiro capacidade de intervenção em contexto pré-hospitalar, suportada pelo seu conhecimento técnico-científico, protocolos complexos de atuação e regulação médica por telemedicina. Objetivo: Analisar os contributos da intervenção dos enfermeiros SIV, na evolução do estado clínico da pessoa em situação crítica (PSC). Metodologia: Estudo quantitativo, descritivo-correlacional, retrospetivo, realizado em meios SIV, na região norte de Portugal. Analisados 574 registos clínicos eletrónicos, entre 01 de novembro e 31 de dezembro de 2019, que correspondem ao mesmo número de pessoas avaliadas. Utilizada a escala National Early Warning Score (NEWS) para avaliar a evolução clínica da PSC. Resultados: Observou-se uma evolução positiva do score NEWS da PSC, após a intervenção do enfermeiro SIV (M = 4,43 ± 3,901 vs 3,34 ± 3,329; sig < 0,001). Em sentido inverso, o risco clínico diminuiu significativamente após a intervenção do enfermeiro. Conclusão: Demonstrou-se a relevância da intervenção do enfermeiro SIV no contexto pré-hospitalar, enquanto garantia de segurança, qualidade e melhoria contínua dos cuidados à PSC.

Abstract Background: Immediate life support (ILS) ambulances allow nurses to intervene in pre-hospital settings, supported by their technical-scientific knowledge and complex protocols of action and regulation through telemedicine. Objective: To analyze the contributions of nursing interventions in the evolution of the clinical state of critical patients. Methodology: Quantitative, descriptive-correlational, retrospective, and observational study conducted in ILS settings in northern Portugal. A total of 574 electronic clinical records were analyzed between 1 November and 31 December 2019, corresponding to the same number of people evaluated. The National Early Warning Score (NEWS) was used to assess the clinical evolution of critical patients. Results: There was a positive evolution of the NEWS score of critical patients after the intervention of ILS nurses (M = 4.43 ± 3.901 vs. 3.34 ± 3.329; sig < 0.001). Similarly, the clinical risk of critical patients decreased after the nurse’s intervention. Conclusion: This study demonstrated the importance of nurses in prehospital care, as a guarantee of safety, quality, and continuous improvement of care for critical patients.

Resumen Marco contextual: La participación del equipo en la acción educativa, problematizando su realidad profesional, mejora los conocimientos teóricos, lo que permite reducir el número de catéteres retirados prematuramente. Objetivo: Evaluar el efecto de una intervención educativa para el equipo de enfermería de una unidad de cuidados intensivos pediátricos para mejorar los conocimientos teóricos sobre la prevención de las complicaciones que causan la retirada no electiva del catéter central de inserción periférica. Metodología: Estudio cuasiexperimental mediante cuestionario antes y después de la intervención educativa, con aplicación de la prueba t Student Pareado, considerando un nivel de significación del 95% y valores p < 0,05 como significativos. Resultados: Aumento del conocimiento teórico tras la intervención educativa, con un aumento de la puntuación media de los técnicos de enfermería de 5,30 (DP = 1,49) para 9,10 (DP = 1,79) y dos enfermeros de 11,83 (DP = 2,12) para 20,67 (DP = 2,46). Conclusión: Se espera que este conocimiento teórico sobre la prevención de complicaciones se haga efectivo en la práctica asistencial, mejorando así las prácticas de mantenimiento y, en consecuencia, reduciendo la retirada prematura del catéter.

Resumo Enquadramento: A participação da equipe de enfermagem nas intervenções educativas utilizando a metodologia da problematização melhora o conhecimento teórico, reduzindo o número de cateteres retirados precocemente. Objetivo: Avaliar o efeito da intervenção educativa na equipa de enfermagem na unidade de terapia intensiva pediátrica na melhoria do conhecimento teórico sobre a prevenção de complicações que ocasionam a remoção não eletiva do cateter central de inserção periférica. Metodologia: Estudo quase-experimental com aplicação de questionário antes e após intervenção educativa, com aplicação do teste t de Student Pareado, considerando-se o nível de significância de 95% e os valores de p < 0,05 significativos. Resultados: Aumento do conhecimento teórico após intervenção, com aumento da média da pontuação dos técnicos em enfermagem de 5,30 (DP = 1,49) para 9,10 (DP = 1,79) e enfermeiros de 11,83 (DP = 2,12) para 20,67 (DP = 2,46). Conclusão: Espera-se que esse conhecimento teórico sobre a prevenção de complicações se efetive no ato de cuidar, promovendo a melhoria da prática de manutenção e, consequentemente, redução das perdas prematuras do cateter.

Abstract Background: The nursing team’s participation in educational interventions using the problematization methodology improves theoretical knowledge, reducing the number of catheters removed early. Objective: To evaluate the effect of an educational intervention on the nursing team of a pediatric intensive care unit in improving theoretical knowledge about the prevention of complications resulting from the unplanned removal of peripherally inserted central catheters. Methodology: A quasi-experimental study was conducted using a questionnaire before and after the educational intervention. The paired Student’s t-test was applied, with a significance level of 95% and a p-value of p < 0.05. Results: Theoretical knowledge increased significantly after the educational intervention. The mean score for nursing technicians increased from 5.30 (SD = 1.49) to 9.10 (SD = 1.79), while the mean score for nurses increased from 11.83 (SD = 2.12) to 20.67 (SD = 2.46). Conclusion: The theoretical knowledge about the prevention of complications should be used to improve catheter maintenance practices and reduce premature catheter loss.