Resumen Objetivo: este artículo estudia la relación entre la demanda turística y el crecimiento económico, el tipo de cambio real y la incertidumbre de política económica (EPU, por sus siglas en inglés) en Australia, China, Francia, Alemania, Italia, Japón, España, Estados Unidos y el Reino Unido. Metodología: se aplicaron pruebas de dependencia transversal, de raíz unitaria y de cointegración. El modelo de largo plazo se estimó con los siguientes métodos: PCSE, FGLS y FMOLS. Resultados: los resultados muestran una relación positiva entre el crecimiento económico y el tipo de cambio real respecto a la demanda turística. En el largo plazo, la relación de causalidad es de la incertidumbre, el tipo de cambio y el PIB al turismo. Se valida la hipótesis de retroalimentación. Limitaciones: la disponibilidad de datos. Originalidad: estudia la influencia conjunta del crecimiento económico y la EPU sobre la demanda de turismo en los países de los principales destinos mundiales de turismo internacional según los ingresos turísticos internacionales. Conclusiones: se sugiere que el turismo impulsará el crecimiento económico general, y de manera correspondiente la inversión en otros sectores de la economía también influirá en un aumento del turismo.

Abstract Objective: to study the relationship among tourism demand and economic growth, real exchange rate, and economic policy uncertainty (EPU) in Australia China, France, Germany, Italy, Japan, Spain, the United States, and the United Kingdom. Methodology: cross-section dependence, unit root, and cointegration tests were applied. The long-term model was estimated according to the Panel-Corrected Standard Error (PCSE), Feasible Generalised Least Squares (FGLS), and Fully Modified Ordinary Least Square (FMOLS). Results: the results show a positive relationship between economic growth and the real exchange rate concerning tourism demand. In the long term, the causality relationship is from uncertainty, exchange rate, and GDP to tourism. The feedback hypothesis is validated. Limitations: availability of data. Originality: it studies the joint influence of economic growth and the EPU on demand for tourism in the countries of the world’s leading destinations for international tourism according to international tourist income. Conclusions: tourism will drive general economic growth and, correspondingly, investment in other sectors of the economy will also influence an increase in tourism.

Abstract: Debates about the memory of traumatic historical experiences are part of contemporary public opinion and historiography. In the cases of Japan and Spain in the 21st century, the difficulties of coming to terms with a traumatic past and developing an inclusive memory of it are related to the different approaches to analyzing such a past. This article proposes a comparative reading of the two countries, based on the tensions and positions found between the present and the past in relation to the Yasukuni Shrine in Japan, and the Valle de los Caídos mausoleum in Spain.

Resumen: Los debates sobre la memoria de experiencias históricas traumáticas forman parte tanto de la opinión pública como de la historiografía actuales. En los casos de Japón y España en el siglo XXI, las dificultades para aproximarse a un pasado traumático y desarrollar una memoria incluyente acerca de él guardan relación con los distintos enfoques sobre cómo mirar ese pasado. En este artículo se propone una lectura comparada sobre ambos países, a partir de la tensión y de las posiciones encontradas entre presente y pasado respecto al santuario Yasukuni en Japón, y el Valle de los Caídos en España.

Abstract The research presents a compilation of the strategies for the handling and management of mercury (Hg) carried out by Japan as a promoter and manager of the Minamata Convention. This agreement was established to reduce anthropogenic mercury emissions and prevent pollution worldwide. Article 14 of the agreement focuses on cooperation between the governments involved and provides technical assistance. That is why the activities were developed in the training course “Capacity building for the ratification and implementation of the Minamata Convention on Mercury” carried out in Japan, in which representatives from Ecuador, China, Sudan, Brazil, and Armenia. Ecuador is one of the countries that ratified this agreement in 2013, which is why it is necessary to understand the efforts developed by other countries, with a practical perspective, to know their feasibility and implementation in the long term in the national territory. This study describes the activities implemented in Japan, such as processing contaminated waste in the company Nomura Kohsan Co., Ltd. (Hokkaido), to know high-tech centers such as the National Institute for Minamata Disease (NIMD) and the Ministry of the Environment (MEGJ), and a tour of the environmental restoration project in Minamata Bay. The results demonstrate that the actions and policies adopted in Japan have considerably reduced Hg emissions, maintaining them at stable levels, which ratifies compliance with the different articles outlined in the Minamata Convention. Although efforts have been made in Ecuador to combat illegal mining where Hg and assist in mining districts, it is still among the most polluting countries in the region. Private and government entities must put effort into action plans to mitigate pollution and carry out periodic monitoring of emissions of this metal.

Resumen La investigación presenta una recopilación de las estrategias en el manejo y gestión del mercurio (Hg) que realiza Japón como promotor y gestor del Convenio de Minamata. Este acuerdo fue establecido para reducir las emisiones antropogénicas de mercurio y prevenir su polución a nivel mundial. El artículo 14 del convenio establece la cooperación entre los gobiernos involucrados y la prestación de asistencia técnica. Es por ello que las actividades se desarrollaron en el curso de capacitación “Capacity building for ratification and implementation of Minamata Convention on Mercury”, llevado a cabo en Japón, en el cual participaron representantes de Ecuador, China, Sudán, Brasil y Armenia. Ecuador es uno de los países que ratificó en el 2013 este convenio, por lo cual es necesario comprender los esfuerzos desarrollados por otros países, desde una perspectiva práctica, para poder conocer su factibilidad y ser implementadas a largo plazo en el territorio nacional. Se describen las actividades implementadas, en Japón, como la recolección y procesamiento de residuos contaminados en la empresa Nomura Kohsan Co., Ltd. (Hokkaido), visita a centros de alta tecnología como el Instituto Nacional para la Enfermedad de Minamata (NIMD) y el Ministerio del Ambiente (MEGJ), y recorrido por el proyecto de restauración ambiental en la bahía de Minamata. Los resultados demuestran que las acciones y políticas adoptadas en Japón han reducido considerablemente las emanaciones de Hg llegando a mantenerlas en niveles estables, lo que ratifica el cumplimiento de los distintos artículos expuestos en el Convenio de Minamata. A pesar de que en Ecuador se han hecho esfuerzos para mitigar el uso de Hg, aun así, se encuentra entre los principales países contaminantes de la región. Las entidades privadas y gubernamentales deben esforzarse en planes de acción para mitigar la contaminación y llevar a cabo monitoreos periódicos de las emisiones de este metal.

Resumen La geopolítica en el ámbito espacial contemporáneo se caracteriza por una compleja red de actores con intereses diversos y capacidades variables. A diferencia de la carrera espacial del siglo XX, actualmente se observa un escenario multipolar con la participación de Estados Unidos (EE. UU.), Europa, Rusia, China, India, Japón y otros actores. Sin embargo, el Derecho Internacional Espacial históricamente ha tenido características de ser reactivo a los cambios, y no proactivo en su regulación. De tal manera, este artículo analiza cuáles son las actuales tendencias en materia de geopolítica espacial y sus implicancias en el Derecho.

Abstract A complex network of actors with diverse interests and varying capacities characterizes Geopolitics in contemporary space. Unlike the space race of the 20th century, a multipolar scenario is currently observed with the active participation of the United States, Europe, Russia, China, India, Japan, and other actors. However, International Space Law has historically had characteristics of being reactive to changes, and not proactive in its regulation. Thus, this article analyses the current trends in space geopolitics and their implications for the Law.

Abstract: In the 1920s Westernization and modernism characterized the cultural life of big Japanese cities, and the cinema quickly became the main entertainment of the urban masses. In this decade studios began to shoot movies following the cinematic techniques and narrative styles of European and American cinema, and increased production of film adaptations of Western literature works popular at that time. This paper focuses on the adaptations of German literature works, specifically of Gerhart Hauptmann plays, produced in Japan during the 1920s. While those films have been lost, stills and reviews of film magazines published at the time of screening have been archived. The study draws on these materials and examines the intertextual and intercultural relations between the films and the literary works. It provides a brief overview on the reception of German literature in Japan, compares the plays and films analysing the permutations in narratological elements, and offers insights on how cultural, political, and social context influenced the directors’ adaptation process. Abstract s cities masses lost archived elements political directors process

Resumen: En los años 1920, la occidentalización y el modernismo caracterizaron la vida cultural de las grandes ciudades japonesas, y el cine rápidamente se convirtió en el principal entretenimiento de las masas urbanas. En esta década, los estudios comenzaron a rodar películas siguiendo las técnicas cinematográficas y los estilos narrativos del cine europeo y americano, y se aumentó la producción de adaptaciones de obras literarias occidentales que eran populares en ese momento. Este artículo se centra en las adaptaciones de obras literarias alemanas, específicamente de las obras de Gerhart Hauptmann, producidas en Japón durante los años 1920. Aunque esas películas se han perdido, se conservan fotogramas y reseñas publicadas en revistas de cine de la época. En este estudio se analizan estos materiales y se examinan las relaciones intertextuales e interculturales entre las películas y las obras literarias. Se proporciona una breve descripción de la recepción de la literatura alemana en Japón, se comparan las obras teatrales y las películas analizando las permutaciones en los elementos narratológicos, y se ofrece una perspectiva sobre cómo el contexto cultural, político y social influyeron en el proceso de adaptación de las obras teatrales. Resumen 1920 japonesas urbanas década americano momento alemanas Hauptmann perdido época narratológicos 192 19 1

Abstract This article offers an analysis of the qualitative transformations in East Asian welfare states since the 2000s. First, I distinguish institutional legacies in light of typologies drawn in the literature: “developmental-inclusive” (Japan and South Korea)”; “individualists” (China, Hong Kong, Malaysia, and Singapore), and “incipient” (Philippines, Indonesia, Thailand, and Vietnam). I argue that the first group has deepened the process of expanding its social policies under a universalist approach, but has redesigned the linkage between industrial policy and social policy, as well as it has fostered defamiliazation policies. China moves away from the “individualist” group towards a “hybrid” type, by greatly expanding public provision, albeit through a dual and stratified system. Finally, the “individualists” and the “incipient” expanding the role of the state on social risks through policies focused on low-income families. 2000s s First literature developmentalinclusive developmental inclusive “developmental-inclusive Japan Korea Korea)” individualists “individualists China, (China Kong Malaysia Singapore, Singapore , Singapore) incipient “incipient Philippines, Philippines (Philippines Indonesia Thailand Vietnam. Vietnam . Vietnam) approach individualist “individualist hybrid “hybrid type provision system Finally lowincome low income families Korea)

Resumo Este artigo oferece uma análise sobre as transformações qualitativas nos Estados de bem-estar do Leste Asiático a partir dos anos 2000. Primeiro, distingo os legados institucionais à luz das tipologias formuladas na literatura: “desenvolvimentistasinclusivos” (Japão e Coreia do Sul)”; os “individualistas” (China, Hong Kong, Malásia e Singapura) e os “incipientes” (Filipinas, Indonésia, Tailândia e Vietnã). Argumento que o primeiro grupo aprofundou o processo de expansão de suas políticas sociais, sob uma abordagem universalista, mas reconfigurou a articulação entre política industrial e política social, bem como desenvolveu substantivamente as políticas de desfamiliarização. A China desloca-se do grupo “individualista” em direção a um tipo “híbrido”, ao ampliar consideravelmente a provisão pública, reproduzindo, contudo, um sistema dual e estratificado. Finalmente, os “individualistas” e os “incipientes” promoveram mudanças residuais, ampliando o papel do Estado sobre os riscos sociais por meio de políticas focalizadas em famílias de baixa renda. JEL: H51, H52, H53, H75, P16. bemestar estar 2000 Primeiro literatura desenvolvimentistasinclusivos “desenvolvimentistasinclusivos Japão Sul Sul)” individualistas “individualistas China, (China Kong Singapura incipientes “incipientes Filipinas, Filipinas (Filipinas Indonésia Vietnã. Vietnã . Vietnã) universalista social desfamiliarização deslocase desloca se individualista “individualista híbrido, híbrido , “híbrido” pública reproduzindo contudo estratificado Finalmente residuais renda JEL H51 H H52 H53 H75 P16 P 200 Sul) “híbrido H5 H7 P1 20 2

INTRODUCTION: The use of glass ionomer cements (GIC) as a restorative material was limited to areas of low masticatory forces due to their low mechanical properties which were also affected by the powder/liquid mixing ratio of this material. Bond strength is important for the clinical success of adhesive material. The shear bond strength (SBS) is the maximum force that an adhesive joint can tolerate before fracture which is tested by SBS tests. The high bond strength helps the adhesive to resist stresses caused by resin contraction and forces for a longer time and thus prevents the problems of bond failure such as recurrent caries, tooth sensitivity and restoration failure. GIC as a restorative material has the capacity to release fluoride and shows good bonding ability. The use of GIC in anterior applications appears to be satisfactory, but they have limitations for use in permanent posterior teeth, particularly with regard to large restorations. Zirconia-reinforced GI (Zirconomer, Shofu Inc, Japan) is a new class of restorative material containing reinforced glass ionomer with special zirconia fillers that promises the strength and durability of amalgam with the protective benefits of glass ionomer while eliminating the hazards of mercury. Amalgomer CR (Advanced Health Care, Tonbridge, Kent, UK), a novel ceramic-reinforced GIC, was introduced, which combines the benefits of GIC with the high strength of ceramics. In the present study, shear bond strength to the dentin with Zirconomer, Amalgomer CR and Fuji type IX GIC (GC Tokyo) are compared. AIM: To evaluate the shear bond strength of three different aesthetic materials to dentin. METHODOLOGY: Thirty extracted human molar teeth were taken, cleaned, stored and the occlusal surfaces of the teeth were flattened with a straight fissured bur at a depth of three millimetres until dentin was exposed. Acrylic blocks were prepared by cold cure acrylic resin and the samples were embedded into the blocks and conditioning of dentin was done using dentin conditioner (GC Corporation Tokyo, Japan). Out of 30 dentin-exposed samples, 10 samples were restored with Zirconomer, the other 10 with Amalgomer CR and the remaining 10 with GIC respectively. All the specimens were transferred to the universal testing machine individually and subjected to shear bond strength analysis. RESULT: Statistical analysis was done for all three groups by using descriptive statistics that include one-way ANOVA and Tukey's multiple post hoc procedures for intergroup comparison. CONCLUSION: Zirconomer showed better shear bond strength than Amalgomer CR and GIC

Abstract Numerous indicators have demonstrated the robustness and resilience of the Chinese development process over the past decades. However, it is not uncommon to perceive, in current analyses, the Chinese process as just another case of successful catching-up, a latecomer of Asian matrix like Japan and South Korea. In fact, Chinese development is not trivial given its history and starting point: in 1949 China was the country with the lowest per capita income in the world and today it is competing with the United States for the technological frontier. In this article, we propose the categories "uneven development", "projectment", and "socialism" as fundamental supports in a background analysis of the real explanatory reasons for the Chinese success. decades However perceive analyses catchingup, catchingup catching up, up catching-up Korea fact point 194 frontier article uneven development, , development" projectment, projectment "projectment" socialism "socialism success 19 "projectment 1

Resumo São inúmeros os indicadores demonstrando a robustez e a resiliência do processo de desenvolvimento chinês ao longo das últimas décadas. Porém, não é incomum perceber nas análises correntes o processo chinês somente como mais um caso de catching-up bem-sucedido; um latecomer de matriz asiática como o Japão e a Coreia do Sul. Na verdade, o desenvolvimento chinês não é nada trivial, tendo em vista sua história e seu ponto de partida: em 1949 a China era o país de menor renda per capita do mundo e hoje disputa a fronteira tecnológica com os Estados Unidos. Propomos, neste artigo, as categorias de “desenvolvimento desigual”, “projetamento” e “socialismo” como suportes fundamentais em uma análise de fundo sobre as reais razões explicativas do sucesso chinês. décadas Porém catchingup catching up bemsucedido bem sucedido bem-sucedido Sul verdade trivial partida 194 Unidos Propomos artigo desigual, desigual , desigual” projetamento “projetamento socialismo “socialismo 19 1

RESUMO Uma alta prevalência de periodontite apical pós-tratamento associada a variáveis como qualidade do tratamento endodôntico e fracasso do tratamento é relatada na literatura. O objetivo deste estudo foi avaliar a qualidade do tratamento endodôntico e a frequência e fracasso do tratamento associados a dentes com periodontite apical (PA) por meio de tomografia computadorizada de feixe cônico (TCFC) em uma subpopulação colombiana. Material e Método Este foi um estudo transversal que avaliou 318 tomografias computadorizadas de dentes tratados endodonticamente de indivíduos colombianos. Os exames foram realizados utilizando o tomógrafo J Morita X550, com tamanho de voxel de 0,125 a 0,20 mm. Todos os dentes tratados endodonticamente foram avaliados quanto à qualidade do tratamento, presença de canais não localizados e AP. Todas as amostras foram avaliadas por dois especialistas em endodontia e um especialista em radiologia. Foram calculados o teste qui-quadrado ou de Fisher e a razão de chances para identificar associação e relação de risco entre a presença de PA e as variáveis do estudo. Resultados Foram encontrados canais não localizados em 18,61% (86/462) e 95,3% estavam associados à PA. A frequência de AP foi de 62,34% (288/462) para todos os dentes avaliados. AP foi encontrada em 27,43% (79/288) dos dentes com tratamento endodôntico adequado, em contraste com 72,57% (209/288) dos dentes com tratamento inadequado (P<0,01). A frequência de canais não localizados foi maior nos molares superiores, com 55,23% (58/105), sendo que 96,55% apresentavam PA. O canal mésio-palatino (MB2) apresentou maior frequência de canal não localizado (88,52% - 54/61), com PA em 90,74% (49/54) dos casos. Conclusão Houve alta frequência de dentes com canais não localizados e com PA. Mais da metade dos dentes com canais não localizados eram molares superiores, sendo o MB2 é o canal com a maior frequência, comumente apresentando periodontite apical.

ABSTRACT A high prevalence of post-treatment apical periodontitis associated to variables such as endodontic treatment quality and missed canals has been reported. Aim The aim of this study was to evaluate the quality of endodontic treatment and the frequency of missed canals associated with teeth with apical periodontitis (AP) through CBCT in a Colombian sub-population. Material and Method This was a crosssectional study assessing 318 cone beam computed tomography (CBCT) scans of endodontically treated teeth from Colombian individuals. The scans were taken using J Morita X550 (J Morita Corporation, Osaka, Japan), with voxel size 0.125 to 0.20 mm. All endodontically treated teeth were assessed for quality of treatment, presence of missed canals and AP. All samples were analyzed by two endodontics specialists and an radiology specialist. Chi-square or Fisher’s test and odds ratio were calculated to identify the association and risk relationship between the presence of AP and the study variables. Results Missed canals were found in 18.61% (86/462), and 95.3% were associated with AP. The frequency of AP was 62.34% (288/462) for all the evaluated teeth. AP was found in 27.43 % (79/288) of the teeth with adequate endodontic treatment, in contrast to 72.57% (209/288) of the teeth with inadequate treatment (P<0.01). The frequency of missed canals was highest in maxillary molars, with 55.23% (58/105), with 96.55% presenting AP. The second mesiobuccal canal was the most frequently missed canal, 88.52% (54/61), with AP in 90.74% (49/54) of the cases. Conclusion There was a high frequency of teeth with missed canals and PA. More than half of the teeth with missed canals were maxillary molars, with MB2 being the most common canal, commonly presenting apical periodontitis.

RESUMO As antocianinas presentes no açaí podem manchar o cimento de ionomero de vidro modificado por resina (CIVMR) devido a baixa resistencia ao manchamento do material. Objetivo O objetivo desse estudo foi avaliar se o açaí compromete a cor e a rugosidade de superficie de um CIVMR in vitro. Materials e Método Amostras (2 mm de espessura, 8 mm de diámetro) de Vitremer™ (3M ESPE, St Paul, MN, USA) foram preparadas de acordo com as instrugoes do fabricante. O materialfoi espatulado, inserido em um molde de silicone colocado entre duas tiras de poliestireno e fotopolimerizado. Após, as amostras foram randomizadas e alocadas em tres grupos (n=25) de acordo com as solugoes usadas para a degradagao química: saliva artificial (controle) e sorbet de açaí e suco de açaí. Utilizou-se o espectrofotometro CM-2600d/2500d (Konica Minolta, Tokyo, Japan) para a análise da cor (escala CIELa*b*) e o rugosímetro Surfcorder SE 1700 (Kosaka Corp, Tokyo, Japan) para a rugosidade de superficie (Ra, mm). As amostras foram submetidas a tres imersoes diárias (6 ml, 15 minutos) em cada solugao por 14 dias a 37°C, tendo sido lavadas em água destilada e mantidas em saliva fresca (30 minutos) nos intervalos. Após a terceira imersao no dia, as amostras foram mantidas em saliva renovada até o dia seguinte. As variáveis foram analisadas antes (L*, a*, b*, Ra) e depois da degradagao química (L’*, a’*, b’*, Ra’). Resultados Os valores de pH da saliva, sorbet e suco foram, respectivamente 7,0, 3,8 e 4,9. Houve diferenga significante para ΔE* entre saliva (p=0.005) e suco (p=0.002) e entre suco e sorbet (p=0.019), mas nao entre saliva e sorbet (p=0.401). Nao foi observada diferenga significante para Δb* entre as solugoes. Nao houve diferenga significante para Δa* entre suco e sorbet, mas eles foram significativamente diferentes da saliva (p<0.001). A luminosidade (L*) mostrou alteragao significante. O suco mostrou os maiores valores de ΔE* (7,8) e ΔL* (7,7)”. Nao houve mudanga significante para a rugosidade e nao foi observada diferenga significante entre as solugoes para ARa (p>0.05). Conclusao O açaí e a saliva causaram manchamento inaceitável do glaze do CIVMR e insignificante alteragao da rugosidade.

ABSTRACT Coloured compounds (anthocyanins) in açaí can stain resin-modified glass-ionomer cement (RMGIC) due to its low staining resistance. Aim The aim of this study was to assess whether açaí compromises the surface colour and roughness of RMGIC in vitro. Materials and Method Disc-shaped specimens (2 mm thick, 8 mm in diameter) of Vitremer™ (3M ESPE, St Paul, MN, USA) were prepared according to the manufacturer ’s instructions. The mixture was inserted into a silicone mouldplaced between two mylar strips, and light cured. Specimens were randomly divided into three groups (n=25) according to the solutions to be used for chemical degradation: artificial saliva (control), açaí sorbet and açaí juice. A spectrophotometer CM-2600d/2500d (Konica Minolta, Tokyo, Japan) was used to analyse the colour (CIELa*b* scale). Surface roughness (Ra, mm) was measuredusing theprofilometer Surfcorder SE 1700 (Kosaka Corp, Tokyo, Japan). The specimens were subjected to three daily soaks (6 ml, 15 minutes) for 14 days at 37°C. They were washed in distilled water and placed in fresh saliva (30 minutes in the interval). After the third soak in a day, they were stored in fresh saliva overnight. Outcomes were analysed at baseline (L*, a*, b*, Ra) and after degradation (L’*, a’*, b’*, Ra’). Results The pH values of saliva, sorbet, and juice were 7.0, 3.8, and 4.9, respectively. ΔE* values were 6.6 for saliva, 6.9 for sorbet and 7.8 for juice. There was a significant ΔE* difference between saliva (p=0.005) and juice (p=0.002), and between juice and sorbet (p=0.019), but none between saliva and sorbet (p=0.401). There was no significant Δb* difference between the solutions. No difference between juice and sorbet was observed for Δa*, but they were significantly different from saliva (p<0.001). Brightness (L*) changed significantly. Juice showed the highest ΔE* (7.8) and ΔL* (7.7). No significant change was observed for roughness and there was no difference between the solutions for ARa. Conclusions Açaí and saliva led to unacceptable staining, but no significant roughness changes in the resin-modified glass-ionomer cement.

RESUMEN Objetivos: mapear la producción de tecnologías destinadas al monitoreo de caídas en un ambiente hospitalario protegido por patentes registradas. Métodos: prospección tecnológica de patentes internacionales, con enfoque cuantitativo, con búsqueda realizada entre febrero y marzo de 2022 en la base de datos Derwent Innovations Index con los descriptores caída, hospital, monitoreo. Resultados: se encontraron 212 patentes, la mayoría presentadas y publicadas desde 2010, por Tran B (9) y Cerner Innovation Inc (9), enfocadas en tecnología de la salud. Las universidades fueron responsables del 13% de los depósitos. Hubo predominio de registros de Estados Unidos (43,4%), China (21,7%) y Japón (12,3%), además de estrategias tecnológicas catalogadas como dispositivos ambientales (80,7%) y para prevenir caídas (66,5%), así como la tendencia hacia recursos con múltiples funcionalidades en una misma tecnología. Conclusiones: la pluralidad de funciones en un mismo dispositivo refleja la búsqueda de optimización de recursos y la preocupación por la atención integral. Objetivos registradas Métodos internacionales cuantitativo 202 caída hospital Resultados 21 2010 9 (9 9, , salud 13 depósitos 43,4%, 434 43,4% 43 4 (43,4%) 21,7% 217 7 (21,7% 12,3%, 123 12,3% 12 3 (12,3%) 80,7% 807 80 (80,7% 66,5%, 665 66,5% 66 5 (66,5%) Conclusiones integral 20 2 201 ( 1 43,4 (43,4% 21,7 (21,7 12,3 (12,3% 80,7 8 (80,7 66,5 6 (66,5% 43, (43,4 21, (21, 12, (12,3 80, (80, 66, (66,5 (43, (21 (12, (80 (66, (43 (2 (12 (8 (66 (4 (1 (6

ABSTRACT Objectives: to map the production of technologies aimed at monitoring falls in a hospital environment protected by registered patents. Methods: a technological prospecting of international patents, with a quantitative approach, with search carried out between February and March 2022 in the Derwent Innovations Index database with descriptors fall, hospital, monitoring. Results: 212 patents were found, with the majority filed and published since 2010, by Tran B (9) and Cerner Innovation Inc (9), focused on health technology. Universities were responsible for 13% of deposits. There was a predominance of records from the United States (43.4%), China (21.7%) and Japan (12.3%), in addition to technological strategies classified as devices for the environment (80.7%) and for preventing falls (66.5%) as well as trend towards resources with multiple functionalities in the same technology. Conclusions: the plurality of functions in the same device reflects the search for optimizing resources and the concern with comprehensive care. Objectives Methods approach 202 fall Results 21 found 2010 9 (9 9, , technology 13 deposits 43.4%, 434 43.4% 43 4 (43.4%) 21.7% 217 7 (21.7% 12.3%, 123 12.3% 12 3 (12.3%) 80.7% 807 80 (80.7% 66.5% 665 66 5 (66.5% Conclusions care 20 2 201 ( 1 43.4 (43.4% 21.7 (21.7 12.3 (12.3% 80.7 8 (80.7 66.5 6 (66.5 43. (43.4 21. (21. 12. (12.3 80. (80. 66. (66. (43. (21 (12. (80 (66 (43 (2 (12 (8 (6 (4 (1

RESUMO Objetivos: mapear a produção de tecnologias voltadas para monitoramento de quedas em ambiente hospitalar protegidas por patentes registradas. Métodos: prospecção tecnológica de patentes internacionais, com abordagem quantitativa, com busca realizada entre fevereiro e março de 2022 na base Derwent Innovations Index com os descritores fall, hospital, monitoring. Resultados: foram encontradas 212 patentes, com maioria depositada e publicada a partir de 2010, por Tran B (9) e Cerner Innovation Inc (9), focadas em tecnologia em saúde. As universidades foram responsáveis por 13% dos depósitos. Houve predomínio de registros dos Estados Unidos (43,4%), da China (21,7%) e Japão (12,3%), além de estratégias tecnológicas classificadas como dispositivos para ambiente (80,7%) e para prevenção de quedas (66,5%), bem como a tendência de recursos com múltiplas funcionalidades em uma mesma tecnologia. Conclusões: a pluralidade de funções em um mesmo dispositivo reflete a busca pela otimização dos recursos e a preocupação com a integralidade do cuidado. Objetivos registradas Métodos internacionais quantitativa 202 fall hospital monitoring Resultados 21 2010 9 (9 9, , saúde 13 depósitos 43,4%, 434 43,4% 43 4 (43,4%) 21,7% 217 7 (21,7% 12,3%, 123 12,3% 12 3 (12,3%) 80,7% 807 80 (80,7% 66,5%, 665 66,5% 66 5 (66,5%) Conclusões cuidado 20 2 201 ( 1 43,4 (43,4% 21,7 (21,7 12,3 (12,3% 80,7 8 (80,7 66,5 6 (66,5% 43, (43,4 21, (21, 12, (12,3 80, (80, 66, (66,5 (43, (21 (12, (80 (66, (43 (2 (12 (8 (66 (4 (1 (6

Bordeaux S is a food dye still allowed in Brazil, being present in soft drinks, gelatins, chewing gums, candies and many other industrialized foodstuffs. Because of its carcinogenic potential, it is forbidden to be added to food in Japan, in the USA and in most of the European Union. Many studies related to the employment of digital images analysis to food quality control have been published in recent years mainly due to its low costs of implementation. Nevertheless, one of the few drawbacks of applying this technique is its poor sensitivity, which can be significantly improved by employing solid substrates, such as chitosan films. In this work, chitosan sorbent films were synthesized, characterized and used to retain Bordeaux S present in gelatin samples, followed by recording the films’ images and quantifying the analyte by digital images analysis. The proposed method was able to extract the analyte and eliminate interferences present in the matrixes in a single step. LOD of 20 µg L-1 and LOQ of 74 µg L-1 were obtained, allowing adequate quantification when considering the recommendations of the Brazilian Health Regulatory Agency (ANVISA). Brazil drinks gelatins gums foodstuffs potential Japan Union implementation Nevertheless sensitivity substrates work synthesized samples step 2 L1 L 1 L- 7 obtained ANVISA. ANVISA . (ANVISA) (ANVISA

ABSTRACT Objective: To investigate the effects of two different dentifrice fluoride concentrations on the color stability of the composite. Material and Methods: Twenty-seven specimens (2×4×5 mm) each of microfilled (Gradia, GC, Japan) and nanohybrid (Grandio, VOCO, Germany) composites were prepared. The specimens were randomly divided into six groups (control, Fluoflor caries protection toothpaste with 1450ppm Fluoride (EXW, France), and Fluoflor kids toothpaste with 500ppm Fluoride (EXW, France) (n = 9). The specimens were immersed in a mixture of artificial saliva and toothpaste in a ratio of 1:3 and applied for 60 seconds every 12 hours for 42 days. The control samples were incubated in artificial saliva at 37°C. Primary and secondary color measurements were performed using color parameters (L∗a∗b) with a spectrophotoshade (MHT Optic Research AG, Niederhasli, Switzerland). Data were analyzed using a two-way analysis of variance at a significance level of 0.05. Results: According to the two-way ANOVA analysis, there was no significant difference in color change between the composites and no difference in the level of discoloration between different fluoride concentrations(p>0.05). Also, None of the dentifrices caused clinically significant color changes(∆E˂3.3). Conclusion: No clinically unacceptable color changes were observed in the microfilled and nanofilled composites with different concentrations of fluoride toothpaste. Objective composite Methods Twentyseven Twenty seven 2×4×5 245 2 4 5 (2×4× mm Gradia, Gradia (Gradia GC Japan Grandio, Grandio (Grandio VOCO Germany prepared control, (control ppm EXW, EXW (EXW France, France , n 9. 9 . 9) 13 1 3 1: 6 days 37C C 37 37°C L∗a∗b Lab L b (L∗a∗b MHT AG Niederhasli Switzerland. Switzerland Switzerland) twoway way 005 0 05 0.05 Results concentrationsp>0.05. concentrationsp005 concentrationsp p>0.05 p concentrations(p>0.05) Also changes∆E˂3.3. changesE33 changesE ∆E˂3.3 E changes(∆E˂3.3) Conclusion 2×4× 24 (2×4 00 0.0 concentrationsp>0.05 concentrationsp00 p005 p>0.0 concentrations(p>0.05 changes∆E˂3.3 changesE3 E33 ∆E˂3. changes(∆E˂3.3 2×4 (2× 0. concentrationsp>0.0 concentrationsp0 p00 p>0. concentrations(p>0.0 changes∆E˂3. E3 ∆E˂3 changes(∆E˂3. 2× (2 concentrationsp>0. p0 p>0 concentrations(p>0. changes∆E˂3 ∆E˂ changes(∆E˂3 ( concentrationsp>0 p> concentrations(p>0 changes∆E˂ ∆E changes(∆E˂ concentrationsp> concentrations(p> changes∆E changes(∆E concentrations(p

Abstract Background This study examines the association of standard-of-care systemic lupus erythematosus (SLE) medications with key outcomes such as low disease activity attainment, flares, damage accrual, and steroid-sparing, for which there is current paucity of data. Methods The Asia Pacific Lupus Collaboration (APLC) prospectively collects data across numerous sites regarding demographic and disease characteristics, medication use, and lupus outcomes. Using propensity score methods and panel logistic regression models, we determined the association between lupus medications and outcomes. Results Among 1707 patients followed over 12,689 visits for a median of 2.19 years, 1332 (78.03%) patients achieved the Lupus Low Disease Activity State (LLDAS), 976 (57.18%) experienced flares, and on most visits patients were taking an anti-malarial (69.86%) or immunosuppressive drug (76.37%). Prednisolone, hydroxychloroquine and azathioprine were utilised with similar frequency across all organ domains; methotrexate for musculoskeletal activity. There were differences in medication utilisation between countries, with hydroxychloroquine less frequently, and calcineurin inhibitors more frequently, used in Japan. More patients taking leflunomide, methotrexate, chloroquine/ hydroxychloroquine, azathioprine, and mycophenolate mofetil/mycophenolic acid were taking ≤ 7.5 mg/day of prednisolone (compared to > 7.5 mg/day) suggesting a steroid-sparing effect. Patients taking tacrolimus were more likely (Odds Ratio [95% Confidence Interval] 13.58 [2.23-82.78], p = 0.005) to attain LLDAS. Patients taking azathioprine (OR 0.67 [0.53-0.86], p = 0.001) and methotrexate (OR 0.68 [0.47-0.98], p = 0.038) were less likely to attain LLDAS. Patients taking mycophenolate mofetil were less likely to experience a flare (OR 0.79 [0.64-0.97], p = 0.025). None of the drugs was associated with a reduction in damage accrual. Conclusions This study suggests a steroid-sparing benefit for most commonly used standard of care immunosuppressants used in SLE treatment, some of which were associated with an increased likelihood of attaining LLDAS, or reduced incidence of flares. It also highlights the unmet need for effective treatments in lupus. standardofcare (SLE attainment flares accrual steroidsparing, steroidsparing steroid sparing, sparing APLC (APLC characteristics use models 170 12689 12 689 12,68 219 2 19 2.1 years 133 78.03% 7803 78 03 (78.03% LLDAS , (LLDAS) 97 57.18% 5718 57 18 (57.18% antimalarial anti malarial 69.86% 6986 69 86 (69.86% 76.37%. 7637 76.37% . 76 37 (76.37%) Prednisolone domains countries frequently Japan leflunomide chloroquine mofetilmycophenolic mycophenolic 75 7 5 7. mgday mg day compared effect Odds 95% 95 [95 Interval 1358 13 58 13.5 2.2382.78, 2238278 2.23 82.78 23 82 [2.23-82.78] 0.005 0005 0 005 OR 067 67 0.6 0.530.86, 053086 0.53 0.86 53 [0.53-0.86] 0.001 0001 001 068 68 0.470.98, 047098 0.47 0.98 47 98 [0.47-0.98] 0.038 0038 038 079 79 0.7 0.640.97, 064097 0.64 0.97 64 [0.64-0.97] 0.025. 0025 0.025 025 0.025) treatment 17 1268 1 12,6 21 2. 78.03 780 (78.03 (LLDAS 9 57.18 571 (57.18 69.86 698 6 8 (69.86 763 76.37 3 (76.37% [9 135 13. 2382 2.2382.78 223827 223 2.2 8278 82.7 [2.23-82.78 0.00 000 00 06 0. 530 0.530.86 05308 053 0.5 086 0.8 [0.53-0.86 470 0.470.98 04709 047 0.4 098 0.9 4 [0.47-0.98 0.03 003 07 640 0.640.97 06409 064 097 [0.64-0.97 002 0.02 02 126 12, 78.0 (78.0 57.1 (57.1 69.8 (69.8 76.3 (76.37 [ 238 2.2382.7 22382 22 827 82. [2.23-82.7 0.0 0.530.8 0530 05 08 [0.53-0.8 0.470.9 0470 04 09 [0.47-0.9 0.640.9 0640 [0.64-0.9 78. (78. 57. (57. 69. (69. 76. (76.3 2.2382. 2238 [2.23-82. 0.530. [0.53-0. 0.470. [0.47-0. 0.640. [0.64-0. (78 (57 (69 (76. 2.2382 [2.23-82 0.530 [0.53-0 0.470 [0.47-0 0.640 [0.64-0 (7 (5 (6 (76 2.238 [2.23-8 [0.53- [0.47- [0.64- ( [2.23- [0.53 [0.47 [0.64 [2.23 [0.5 [0.4 [0.6 [2.2 [0. [2. [0 [2

ABSTRACT Fasciola species are the causative agents of liver fluke disease (fasciolosis) which is primarily found in domestic and wild ruminants but also are causal agents of fascioliasis in humans. Few reports for the genotyping of Fasciola species in Saudi Arabia were available. This study aimed to identify the Fasciola species infecting sheep using morphology and molecular tools. For that, livers of 500 imported sheep were slaughtered at abattoirs located in Riyadh (Saudi Arabia), and parasite species were isolated from 28 liver samples and then preserved for subsequent stages in this study. These parasite species were identified as Fasciola hepatica and Fasciolagigantica via morphology and confirmed via the 28S rRNA, ITS-1, COI, and NDI sequences with a close identity for other Fasciola species within the family Fasciolidae. Phylogenetic analysis of the obtained sequences showed that Fasciola isolates from the current study were clustered in one subclade closely related to isolates from Iran, Vietnam, Australia, South Africa, Eastern Europe, India, Egypt, Sudan, Japan, Poland, Spain, Armenia, and Turkey. A combination of data from morphology and molecular analysis could be considered a useful tool for identifying Fasciola species infecting sheep in Saudi Arabia. fasciolosis (fasciolosis humans available tools 50 Arabia, , Arabia) 2 S rRNA ITS1, ITS1 ITS 1, 1 ITS-1 COI Fasciolidae Iran Vietnam Australia Africa Europe India Egypt Sudan Japan Poland Spain Armenia Turkey 5 ITS-

RESUMO As espécies de Fasciolasãoosagentescausadores da doença da fascíolahepática (fasciolose), encontradaprincipalmenteemruminantesdomésticos e selvagens, mas tambémsãoagentescausadores da fasciolíaseemhumanos. Haviapoucosrelatos de genotipagem de espécies de FasciolanaArábiaSaudita. O objetivodesteestudofoiidentificar as espécies de Fasciola que infectamovinosusando ferramentas morfológicas e moleculares. Para isso, fígados de 500 ovelhasimportadasforamabatidosemmatadouroslocalizadosemRiad (ArábiaSaudita), e espécies de parasitasforamisoladas de 28 amostras de fígado e preservadas para as etapassubsequentesdesteestudo. Essasespécies de parasitasforamidentificadascomoFasciola hepatica e Fasciolagigantica por meio da morfologia e confirmadas por meio das sequências 28S rRNA, ITS-1, COI e NDI com umaidentidadepróximaaoutrasespécies de Fasciola dentro da famíliaFasciolidae. A análisefilogenética das sequênciasobtidasmostrou que osisolados de Fasciola do presenteestudoforamagrupadosem um subcladointimamenterelacionado a isolados do Irã, Vietnã, Austrália, África do Sul, Europa Oriental, Índia, Egito, Sudão, Japão, Polônia, Espanha, Armênia e Turquia. Uma combinação de dados de morfologia e análise molecular pode ser consideradauma ferramenta útil para identificarespécies de Fasciola que infectamovinosnaArábiaSaudita. fasciolose, fasciolose , (fasciolose) selvagens fasciolíaseemhumanos FasciolanaArábiaSaudita moleculares isso 50 ArábiaSaudita, ArábiaSaudita (ArábiaSaudita) 2 etapassubsequentesdesteestudo S rRNA ITS1, ITS1 ITS 1, 1 ITS-1 famíliaFasciolidae Irã Vietnã Austrália Sul Oriental Índia Egito Sudão Japão Polônia Espanha Turquia infectamovinosnaArábiaSaudita (fasciolose 5 (ArábiaSaudita ITS-