Abstract Objective: To examine the mental health status and related factors in children and adolescents, and to assess age groups and sexes differences in factors influencing mental health. Methods: This cross-sectional study was performed on Chinese children aged 6-18 years from November 2021 to January 2022. Mental health difficulties were accessed by the Strengths and Difficulties Questionnaire. Multivariate logistic regression was used to analyze factors associated with mental health status. Multiple linear regression was used to evaluate factors associated with the scores of the Strengths and Difficulties Questionnaire. Results: The prevalence of mental health difficulties was 12.98% (n =1348). Age (OR, 0.909, [95%CI, 0.830-0.996]), sex (OR, 1.424, [95%CI, 1.033-1.963]) and screen time on weekdays (“≥2” h/d vs “< 1” h/d: OR, 2.001, [95%CI, 1.300-3.080]) were related factors for mental health difficulties. For children (year ≤ 12), the strongest related factor for mental health difficulties was screen time on weekdays (“≥ 2” h/d vs “< 1” h/d: OR, 1.821 [95%CI, 1.203-2.755]). The risk of mental health difficulties in females with ≥ 2 h/d screen time on weekends was 3.420 times higher than those with < 1 h/d (OR, 3.420, [95%CI, 1.923-6.081]). Conclusion: The prevalence of mental health difficulties among children and adolescents was relatively high. The lower age, female sex and excessive screen time were associated with a higher risk of mental health difficulties. The factors influencing mental health varied by different age groups and sexes. Thus, specific measures for different age groups and sexes should be adopted to mitigate the impact. Objective Methods crosssectional cross sectional 618 6 18 6-1 202 2022 Questionnaire Results 1298 12 98 12.98 n =1348. 1348 =1348 . =1348) OR (OR 0909 0 909 0.909 95%CI, 95CI CI 95 [95%CI 0.8300.996, 08300996 0.830 0.996 , 830 996 0.830-0.996]) 1424 424 1.424 1.0331.963 10331963 1.033 1.963 033 963 1.033-1.963] ≥2 (“≥2 hd h d “ 2001 001 2.001 1.3003.080 13003080 1.300 3.080 300 3 080 1.300-3.080] year 12, 12) (“ 1821 821 1.82 1.2032.755. 12032755 1.203 2.755 203 755 1.203-2.755]) 3420 420 3.42 1.9236.081. 19236081 1.923 6.081 923 081 1.923-6.081]) Conclusion high Thus impact 61 6- 20 129 9 12.9 134 =134 090 90 0.90 95%CI 8300 0.8300.996 0830099 0830 0.83 0996 0.99 83 99 0.830-0.996] 142 42 1.42 0331 1.0331.96 1033196 1033 1.03 1963 1.96 03 96 1.033-1.963 200 00 2.00 3003 1.3003.08 1300308 1300 1.30 3080 3.08 30 08 1.300-3.080 ( 182 82 1.8 2032 1.2032.755 1203275 1203 1.20 2755 2.75 75 1.203-2.755] 342 3.4 9236 1.9236.081 1923608 1923 1.92 6081 6.08 92 1.923-6.081] 12. 13 =13 09 0.9 0.8300.99 083009 083 0.8 099 8 0.830-0.996 14 4 1.4 1.0331.9 103319 103 1.0 196 1.9 1.033-1.96 2.0 1.3003.0 130030 130 1.3 308 3.0 1.300-3.08 1. 1.2032.75 120327 120 1.2 275 2.7 7 1.203-2.755 34 3. 1.9236.08 192360 192 608 6.0 1.923-6.081 =1 0. 0.8300.9 08300 0.830-0.99 1.0331. 10331 10 19 1.033-1.9 2. 1.3003. 13003 1.300-3.0 1.2032.7 12032 27 1.203-2.75 1.9236.0 19236 60 6. 1.923-6.08 = 0.8300. 0.830-0.9 1.0331 1.033-1. 1.3003 1.300-3. 1.2032. 1.203-2.7 1.9236. 1.923-6.0 0.8300 0.830-0. 1.033-1 1.300-3 1.2032 1.203-2. 1.9236 1.923-6. 0.830-0 1.033- 1.300- 1.203-2 1.923-6 0.830- 1.203- 1.923-

ABSTRACT Introduction: Although most individuals recover after acute infection by SARS-CoV-2, others may suffer from persistent symptoms with potential medium and long-term consequences on the performance of activities and participation, with possible implications for their fitness for work. Objective: To analyze the persistence of symptoms twelve months after SARS-CoV-2 infection, and the perception of the performance level in activities and participation in life situations, of workers in a company of the industrial sector in the Aveiro Region. Methodology: An observational study, developed in an Occupational Health Service of an industrial company in the region of Aveiro, including workers with positive SARS-COV-2 RT-PCR/TRAg test, between October/2020-January/2022. After signaling the infection, the Occupational Health Team applied a questionnaire collecting sociodemographic variables, a list of common symptoms during the acute phase of infection by SARS-COV-2, and the perceived functionality assessed by the Portuguese version of WHODAS 2.0-PT12 (where '12 points' means the most functionality). At twelve months, they filled out another list of persistent symptoms after SARS-CoV-2 infection and again WHODAS 2.0-PT12. Data analysis included descriptive statistics and univariate and multivariate linear regression. The analysis was conducted with the software JASP 0.16.3. Results: Eighty-five workers were infected with SARS-CoV-2, with a mean age of 36.1± 9.8years, 77.7% were male, 36.7% had higher education and 17.7% reported at least one chronic condition. At twelve months, thirty workers (35.3%) reported persistent symptoms, with fatigue (27.7%) and arthralgia (14.4%) being the most mentioned. The mean WHODAS 2.0 in the two evaluation moments was 19.2±8.0 vs 15.7±5.0. Significant associations between WHODAS 2.0 items and persistent symptoms of fatigue, headache, cough, myalgia, arthralgia, and previous chronic disease were found. Conclusions: Persistent symptoms twelve months after acute SARS-CoV-2 infection have repercussions on workers' self-perception of performance in some activities and participation in life situations. The occupational health team can implement continuous surveillance of the infected worker's health, assess the presence of persistent symptoms of this infection, and implement an individualized rehabilitation program, which minimizes the impact of the persistence of symptoms on their work performance, and in activities and participation in life situations.

RESUMO Introdução: Embora a maioria dos indivíduos recupere após a infeção aguda por SARS-CoV-2, outros podem apresentar sintomas persistentes com potenciais consequências a médio e longo prazo no desempenho de atividades e participação, com eventuais implicações na sua aptidão para o trabalho. Objetivo: Analisar a persistência de sintomas aos doze meses após infeção por SARS-CoV-2 e perceção do nível de desempenho em atividades e participação em situações de vida de trabalhadores do setor industrial numa empresa da Região de Aveiro. Metodologia: Estudo observacional, desenvolvido num Serviço de Saúde Ocupacional de uma empresa industrial da região de Aveiro, incluindo trabalhadores com teste SARS-COV-2 RT-PCR/TRAg positivo, entre outubro/2020-janeiro/2022. Após sinalização da infeção, a Equipa de Saúde Ocupacional aplicou um questionário recolhendo as variáveis sociodemográficas, uma lista de sintomas comuns durante a fase aguda da infeção por SARS-COV-2 e a funcionalidade percebida avaliada pela versão portuguesa da WHODAS 2.0-PT12 (onde '12 pontos' significa a maior funcionalidade). Aos doze meses, preencheram outra lista de sintomas persistentes após a infeção por SARS-CoV-2 e novamente a WHODAS 2.0-PT12. A análise dos dados incluiu estatística descritiva e regressão logística univariada e multivariada. A condução da análise foi realizada com o software JASP 0,16.3. Resultados: Oitenta e cinco trabalhadores encontravam-se infetados com SARS-CoV-2, com idade média de 36,1±9,8anos, 77,7% eram do sexo masculino, 36,7% possuíam escolaridade superior e 17,7% relataram pelo menos uma condição crónica. Aos doze meses, trinta trabalhadores (35,3%) relataram sintomas persistentes, sendo a fadiga (27,7%) e artralgia (14,4%) os mais mencionados. A média da WHODAS 2.0 nos dois momentos de avaliação foi 19,2±8,0 vs 15,7±5,0. Foram encontradas associações significativas entre os itens da WHODAS 2.0 e os sintomas persistentes fadiga, cefaleia, tosse, mialgia, artralgia e doença crónica prévia. Conclusões: Os sintomas persistentes doze meses após a infeção aguda por SARS-CoV-2 têm repercussão na autoperceção do desempenho em algumas atividades e participação em situações de vida dos trabalhadores. A equipa de saúde ocupacional deve realizar a vigilância contínua da saúde do trabalhador infetado, avaliando a presença de sintomas persistentes desta infeção e poderá implementar um programa de intervenção individualizado, que minimize o impacto da persistência dos sintomas no seu desempenho laboral, assim como, em atividades e participação em situações de vida.

BACKGROUND. Adolescent girls and young women (AGYW) remain vulnerable to HIV, with a higher incidence rate than their male counterparts. OBJECTIVES. To determine the prevalence of and factors associated with HIV testing among AGYW in South Africa (SA). METHODS. A cross-sectional design was used to analyse the South Africa Demographic and Health Survey 2016. Only sexually active AGYW aged 15 - 24 years residing in SA at the time of the survey were included. Descriptive statistics were used to analyse baseline sociodemographic characteristics. Univariate and multivariate logistic regression models were used to determine factors associated with HIV testing. Statistical significance was set at p<0.05, and all analyses were adjusted using survey weights to account for unequal selection probabilities. RESULTS. The overall prevalence of HIV testing among sexually active AGYW was 85.2% (95% confidence interval (CI) 83.0 - 87.1). The AGYW who had a history of pregnancy (adjusted odds ratio (aOR) 4.47; 95% CI 2.90 - 6.89), were employed (aOR 3.29; 95% CI 1.75 - 6.21), belonged to a middle wealth index (aOR 1.80; 95% CI 1.04 - 3.10), had knowledge about mother-to-child transmission of HIV (aOR 3.29; 95% CI 2.26 - 4.79), had visited a health facility during the past 12 months (aOR 2.93; 95% CI 2.09 - 4.10), or had secondary/tertiary education (aOR 2.04; 95% CI 1.04 - 3.99) had higher odds of HIV testing. CONCLUSION. The study identified an unmet need for HIV testing among sexually active AGYW in SA, especially adolescent girls aged 15 - 19 years. Increasing knowledge about HIV testing, adolescent-friendly services and other offsite strategies are therefore important for this particular key population.

ABSTRACT The program of information and communications technologies has been implemented in all the institutions belonging to the health sector in Cuba, because it favors the training through the teaching and learning environments in function of development and academic perspectives, by means of technological platforms to facilitate the exchange of information. In this work the necessity to increase the wiki use as educational tool in enhanced, that favors the collaborative learning as a process of knowledge creation through the web 2.0, where contents are not only published but also contributes to develop cooperation abilities in the training processes of public health.

RESUMEN El programa de las tecnologías de la información y las comunicaciones se ha implementado en todas las instituciones pertenecientes al sector de la salud en Cuba, pues favorece la formación a través de los entornos de enseñanza y aprendizaje en función del desarrollo y las perspectivas académicas, mediante plataformas tecnológicas para facilitar el intercambio de información. En el presente artículo se destaca la necesidad de incrementar el uso de la wiki como herramienta educativa, que favorece el aprendizaje colaborativo como un proceso de creación de conocimiento a través de la web 2.0, donde no solo se publican contenidos sino que contribuye a desarrollar habilidades de cooperación en los procesos formativos de la salud pública.

Abstract Background Atrial fibrillation (AF) and heart failure (HF) frequently coexist, resulting in adverse outcomes. However, controversies remain regarding the efficacy of catheter ablation (CA) in AF patients with severe left ventricular dysfunction. Objectives The purpose of this study was to perform a meta-analysis of prospective randomized controlled trials to evaluate the efficacy of CA versus medical therapy (MT) in AF patients with left ventricular ejection fraction (LVEF) ≤45%. Methods We searched the literature for studies that compared CA to MT in AF patients with LVEF ≤45%. A meta-analysis of 7 clinical trials was performed, including 1163 patients with AF and HF. Subgroup analysis was performed based on baseline LVEF. All tests were 2-sided; only the p-value <0.05 was considered statistically significant. Results We found that CA was associated with lower all-cause mortality (risk ratio: 0.52, 95% CI: 0.37 to 0.72; p<0.01) and greater improvements in LVEF (mean difference: 4.80%, 95% CI: 2.29% to 7.31%; p<0.01) compared to MT. Patients in the CA group had a lower risk of HF hospitalization and AF recurrence and a significantly better quality of life than those in the MT group. The results of subgroup analysis indicated that patients with milder left ventricular dysfunction improved LVEF after AF ablation (mean difference: 6.53%, 95% CI: 6.18% to 6.88%; p<0.01) compared to patients with more severe disease (mean difference: 2.02%, 95% CI: 0.87% to 3.16%; p<0.01). Conclusions Our meta-analysis demonstrated that CA was associated with significant improvements in outcomes of AF patients with LVEF ≤45%. Additionally, AF patients with milder left ventricular dysfunction could benefit more from CA. (AF (HF coexist However (CA metaanalysis meta (MT (LVEF 45 ≤45% 116 2sided sided 2 2-sided pvalue p value 005 0 05 <0.0 allcause all cause ratio 052 52 0.52 95 CI 037 37 0.3 0.72 072 72 p<0.01 p001 01 mean difference 480 4 80 4.80% 229 29 2.29 7.31% 731 31 653 6 53 6.53% 618 18 6.18 6.88% 688 88 202 02 2.02% 087 87 0.87 3.16% 316 3 16 p<0.01. . Additionally ≤45 11 00 <0. 5 0.5 9 03 0. 0.7 07 p<0.0 p00 48 8 4.80 22 2.2 7.31 73 65 6.53 61 1 6.1 6.88 68 20 2.02 08 0.8 3.16 ≤4 <0 p<0. p0 4.8 2. 7.3 6.5 6. 6.8 2.0 3.1 ≤ < p<0 4. 7. 3. p<

Resumo Fundamento A fibrilação atrial (FA) e a insuficiência cardíaca (IC) coexistem frequentemente, resultando em desfechos adversos. No entanto, permanecem controvérsias quanto à eficácia da ablação por cateter (AC) em pacientes com FA com disfunção ventricular esquerda grave. Objetivos O objetivo deste estudo foi realizar uma metanálise de ensaios prospectivos randomizados e controlados para avaliar a eficácia da AC versus terapia médica (TM) em pacientes com FA com fração de ejeção do ventrículo esquerdo (FEVE) ≤45%. Métodos Procuramos na literatura estudos que comparassem AC com TM em pacientes com FA com FEVE ≤45%. Foi realizada uma metanálise de 7 ensaios clínicos, incluindo 1.163 pacientes com FA e IC. A análise de subgrupo foi realizada com base na FEVE basal. Todos os testes foram bilaterais; apenas o valor p <0,05 foi considerado estatisticamente significativo. Resultados Descobrimos que a AC estava associada a menor mortalidade por todas as causas (taxa de risco: 0,52, IC 95%: 0,37 a 0,72; p<0,01) e maiores melhorias na FEVE (diferença média: 4,80%, IC 95%: 2,29% a 7,31%; p<0,01) em comparação com TM. Os pacientes do grupo AC apresentaram menor risco de hospitalização por IC e recorrência de FA e qualidade de vida significativamente melhor do que aqueles do grupo TM. Os resultados da análise de subgrupo indicaram que pacientes com disfunção ventricular esquerda mais leve melhoraram a FEVE após a ablação de FA (diferença média: 6,53%, IC 95%: 6,18% a 6,88%; p<0,01) em comparação com pacientes com doença mais grave (diferença média : 2,02%, IC 95%: 0,87% a 3,16%; p<0,01). Conclusões Nossa metanálise demonstrou que a AC foi associada a melhorias significativas nos resultados de pacientes com FA com FEVE ≤45%. Além disso, pacientes com FA com disfunção ventricular esquerda mais leve poderiam se beneficiar mais com a AC. (FA (IC frequentemente adversos entanto (AC (TM (FEVE 45 ≤45% clínicos 1163 1 163 1.16 basal bilaterais 005 0 05 <0,0 significativo taxa 052 52 0,52 95% 95 037 37 0,3 0,72 072 72 p<0,01 p001 01 diferença 480 4 80 4,80% 229 2 29 2,29 7,31% 731 31 653 6 53 6,53% 618 18 6,18 6,88% 688 88 202 02 2,02% 087 87 0,87 3,16% 316 3 16 p<0,01. . disso ≤45 116 1.1 00 <0, 5 0,5 9 03 0, 0,7 07 p<0,0 p00 48 8 4,80 22 2,2 7,31 73 65 6,53 61 6,1 6,88 68 20 2,02 08 0,8 3,16 ≤4 11 1. <0 p<0, p0 4,8 2, 7,3 6,5 6, 6,8 2,0 3,1 ≤ < p<0 4, 7, 3, p<

RESUMEN Introducción: Como la Organización Mundial de la Salud declaró el nuevo coronavirus como una pandemia en marzo de 2020, la fisioterapia es más difícil de ejecutar, el distanciamiento social es obligatorio en el sector de la salud. Objetivo: En la práctica de fisioterapia un software de análisis de vídeo online que proporcione información gráfica y numérica en tiempo real sobre las ejecuciones de movimiento del paciente sin contacto personal directo supondría una mejora significativa en el tratamiento de la eSalud. Métodos: Fue desarrollado una capa de software sobre el software de estimación de posición del cuerpo humano OpenPose que puede extraer la serie temporal de ángulos de partes arbitrarias del cuerpo utilizando las coordenadas de salida de OpenPose procesando los datos registrados por dos cámaras simultáneamente. Para validar el procedimiento de determinación de los ángulos articulares mediante el software Openpose fue utilizado el software Kinovea. Resultados: La comparación del ángulo máximo de rodilla determinado en nuestro software y Kinovea, que es ampliamente utilizado en mediciones biomecánicas, no fue significativamente diferente (2,03±1,06°, p<0,05). Conclusión: Esto indica que el software desarrollado puede calcular los ángulos articulares adecuados con la precisión que requieren los tratamientos de fisioterapia. Dado que aún no existe dicho software, con la ayuda de este desarrollo de software, los terapeutas podrían controlar y corregir los ejercicios en tiempo real, y también a distancia, y se podría aumentar la eficacia de la fisioterapia. Nivel de Evidencia II; Experimental, comparativo. Introducción 2020 ejecutar salud Objetivo eSalud Métodos simultáneamente Kinovea Resultados biomecánicas 2,03±1,06°, 203106 2 03 1 06 (2,03±1,06° p<0,05. p005 p p<0,05 . 0 05 p<0,05) Conclusión distancia II Experimental comparativo 202 2,03±1,06° 20310 (2,03±1,06 p00 p<0,0 20 2,03±1,06 2031 (2,03±1,0 p0 p<0, 2,03±1,0 203 (2,03±1, p<0 2,03±1, (2,03±1 p< 2,03±1 (2,03± 2,03± (2,03 2,03 (2,0 2,0 (2, 2, (2 (

ABSTRACT Introduction: As the World Health Organization declared the novel coronavirus as a pandemic in March 2020, physical therapy is more difficult to execute, and social distancing is mandatory in the healthcare sector. Objective: In physical therapy, an online video analysis software that provides real-time graphic and numerical information about the patient’s movement executions without direct personal contact would mean a significant improvement in eHealth treatment. Methods: We have developed a software layer on top of OpenPose human body position estimation software that can extract the time series of angles of arbitrary body parts using the output coordinates from OpenPose processing the data recorded by two cameras simultaneously. To validate the procedure of determining the joint angles using the Openpose software we have used the Kinovea software. Results: The comparison of the determined maximal knee angle in our and the Kinovea software, which is widely used in biomechanical measurements, was not significantly different (2.03±1.06°, p<0.05) Conclusion: This indicates, that the developed software can calculate the appropriate joint angles with the accuracy that physiotherapy treatments require. As, to our knowledge no such software yet exists, with the help of this software development, therapists could control and correct the exercises in real-time, and also from a distance, and physical therapy effectiveness could be increased. Level of Evidence II; Experimental, comparative. Introduction 2020 execute sector Objective realtime real patients patient s treatment Methods simultaneously Results measurements 2.03±1.06°, 203106 2 03 1 06 (2.03±1.06° p<0.05 p005 p 0 05 Conclusion indicates require exists development realtime, time, distance increased II Experimental comparative 202 2.03±1.06° 20310 (2.03±1.06 p<0.0 p00 20 2.03±1.06 2031 (2.03±1.0 p<0. p0 2.03±1.0 203 (2.03±1. p<0 2.03±1. (2.03±1 p< 2.03±1 (2.03± 2.03± (2.03 2.03 (2.0 2.0 (2. 2. (2 (

RESUMO Introdução: Como a Organização Mundial da Saúde declarou o novo coronavírus como pandemia em março de 2020, a fisioterapia é mais difícil de executar, o distanciamento social é obrigatório no setor de saúde. Objetivo: Na prática da fisioterapia, um software de análise de vídeo online que fornece informações gráficas e numéricas em tempo real sobre as execuções de movimento do paciente sem contato pessoal direto significaria uma melhora significativa no tratamento eHealth. Métodos: Desenvolveu-se uma camada de software em cima do software de estimativa de posição do corpo humano OpenPose que pode extrair as séries temporais de ângulos de partes do corpo arbitrárias usando as coordenadas de saída do OpenPose processando os dados gravados por duas câmeras simultaneamente. Para validar o procedimento de determinação dos ângulos articulares utilizando o software Openpose utilizou-se o software Kinovea. Resultados: A comparação do ângulo máximo do joelho determinado em nosso e no software Kinovea, amplamente utilizado em medidas biomecânicas, não foi significativamente diferente (2,03±1,06°, p<0,05) Conclusão: Isso indica que o software desenvolvido pode calcular os ângulos articulares adequados com a precisão que os tratamentos de fisioterapia exigem. Como esse software ainda não existe, com a ajuda do desenvolvimento desse software, os terapeutas puderam controlar e corrigir os exercícios em tempo real, e também à distância, aumentando a eficácia da fisioterapia. Nível de Evidência II; Experimental, comparativo. Introdução 2020 executar saúde Objetivo eHealth Métodos Desenvolveuse Desenvolveu se simultaneamente utilizouse utilizou Kinovea Resultados biomecânicas 2,03±1,06°, 203106 2 03 1 06 (2,03±1,06° p<0,05 p005 p 0 05 Conclusão exigem existe distância II Experimental comparativo 202 2,03±1,06° 20310 (2,03±1,06 p<0,0 p00 20 2,03±1,06 2031 (2,03±1,0 p<0, p0 2,03±1,0 203 (2,03±1, p<0 2,03±1, (2,03±1 p< 2,03±1 (2,03± 2,03± (2,03 2,03 (2,0 2,0 (2, 2, (2 (

ABSTRACT Objective: To evaluate quality indicators of the Neonatal Screening Referral Service of the state of Mato Grosso (NSRS-MT) from 2005 to 2019. Methods: Cross-sectional, retrospective, exploratory, descriptive, and observational study from 2005 to 2019. The following parameters were analyzed: age of newborns at the first collection, time between sample collection and arrival at the laboratory, time between the arrival and release of results and time between requesting the second sample and arrival at the NSRS. The population coverage of the program and the incidence of each clinical situation screened were also analyzed. Results: NSRS-MT coverage was analyzed and recorded as 76%. The incidence was analyzed for congenital hypothyroidism (CH) 1:1867, phenylketonuria (PKU) 1:33,311, sickle cell disease (SCD) 1:2004, cystic fibrosis (CF) 1:12,663, congenital adrenal hyperplasia (CAH) 1:15,843, and biotinidase deficiency (DB) 1:25,349. The median age (days) at the first consultation was: 44 for HC, 22 for PKU, 60 for DF, 52 for FC, 79 for HAC and 79 for DB. The mean time between exam collection and delivery to the NSRS was 8.4 days; between the arrival and release of results, 9 days; and for the return of recalls, 59 days. Conclusions: Regarding the coverage of the target population and collection at the ideal age, the NSRS-MT presents values below the national average. However, regarding the mean age at the time of the first consultation, the state's performance is better than the national. Objective NSRSMT MT (NSRS-MT 200 2019 Methods Crosssectional, Crosssectional Cross sectional, sectional Cross-sectional retrospective exploratory descriptive laboratory Results 76 76% CH (CH 11867, 11867 1 1867, 1867 1:1867 PKU (PKU 133,311, 133311 33,311, 33 311 1:33,311 SCD (SCD 12004, 12004 2004, 2004 1:2004 CF (CF 112,663, 112663 12,663, 12 663 1:12,663 CAH (CAH 115,843, 115843 15,843, 15 843 1:15,843 DB (DB 125,349. 125349 25,349. 25 349 1:25,349 days (days 4 HC 2 6 DF 5 FC 7 84 8 8. recalls Conclusions average However states s 20 201 1186 186 1:186 133 133,311 13331 33311 33,311 3 31 1:33,31 1200 1:200 112 112,663 11266 12663 12,663 66 1:12,66 115 115,843 11584 15843 15,843 1:15,84 125 125,349 12534 25349 25,349 34 1:25,34 118 18 1:18 13 133,31 1333 3331 33,31 1:33,3 120 1:20 11 112,66 1126 1266 12,66 1:12,6 115,84 1158 1584 15,84 1:15,8 125,34 1253 2534 25,34 1:25,3 1:1 133,3 333 33,3 1:33, 1:2 112,6 126 12,6 1:12, 115,8 158 15,8 1:15, 125,3 253 25,3 1:25, 1: 133, 33, 1:33 112, 12, 1:12 115, 15, 1:15 125, 25, 1:25 1:3

RESUMO Objetivo: Avaliar indicadores de qualidade do Serviço de Referência em Triagem Neonatal do Estado de Mato Grosso (SRTN/MT) no período de 2005 a 2019. Métodos: Estudo transversal, retrospectivo, exploratório, descritivo e observacional, que utilizou dados do formulário FormSUS nos anos de 2005 a 2019. Foram analisados os seguintes parâmetros: idade dos recém-nascidos na primeira coleta, tempo entre coleta da amostra e chegada ao laboratório, tempo entre a chegada e a liberação dos resultados e tempo entre a solicitação da segunda amostra até a chegada ao SRTN. Foram analisadas, também, a cobertura populacional do programa e a incidência de cada situação clínica triada. Resultados: Cobertura do SRTN-MT: 76%. Incidências: hipotireoidismo congênito (HC) 1:1.867, fenilcetonúria (PKU) 1:33.311, doença falciforme (DF) 1:2.004, fibrose cística (FC) 1:12.663, hiperplasia adrenal congênita (HAC) 1:15.843 e deficiência de biotinidase (DB) 1:25.349. A mediana da idade (dias) na primeira consulta foi: 44 para HC, 22 para PKU, 60 para DF, 52 para FC, 79 para HAC e 79 para DB. A média entre a coleta do exame e a entrega no SRTN foi de 8,4 dias; entre a chegada e liberação dos resultados, de 9 dias; e para o retorno de reconvocados, de 59 dias. Conclusões: Com relação à cobertura da população alvo e a coleta na idade ideal, o SRTN apresenta valores abaixo da média nacional. Contudo, quanto à idade média no momento da primeira consulta, o desempenho de MT é melhor que a média nacional. Objetivo SRTN/MT SRTNMT (SRTN/MT 200 2019 Métodos transversal retrospectivo exploratório observacional parâmetros recémnascidos recém nascidos laboratório analisadas também triada Resultados SRTN-MT 76 76% Incidências HC (HC 11.867, 11867 1 1.867, 867 1:1.867 PKU (PKU 133.311, 133311 33.311, 33 311 1:33.311 DF (DF 12.004, 12004 2.004, 2 004 1:2.004 FC (FC 112.663, 112663 12.663, 12 663 1:12.663 (HAC 115.843 115843 15.843 15 843 1:15.84 DB (DB 125.349. 125349 25.349. 25 349 1:25.349 dias (dias 4 6 5 7 84 8 8, reconvocados Conclusões ideal nacional Contudo 20 201 11 11.867 1186 1867 1.867 86 1:1.86 133 133.311 13331 33311 33.311 3 31 1:33.31 12.004 1200 2004 2.004 00 1:2.00 112 112.663 11266 12663 12.663 66 1:12.66 115 115.84 11584 15843 15.84 1:15.8 125 125.349 12534 25349 25.349 34 1:25.34 11.86 118 186 1.86 1:1.8 13 133.31 1333 3331 33.31 1:33.3 12.00 120 2.00 0 1:2.0 112.66 1126 1266 12.66 1:12.6 115.8 1158 1584 15.8 1:15. 125.34 1253 2534 25.34 1:25.3 11.8 18 1.8 1:1. 133.3 333 33.3 1:33. 12.0 2.0 1:2. 112.6 126 12.6 1:12. 115. 158 15. 1:15 125.3 253 25.3 1:25. 11. 1. 1:1 133. 33. 1:33 12. 2. 1:2 112. 1:12 125. 25. 1:25 1: 1:3

Abstract Background: Cardiovascular diseases (CVD) have significant health and economic burdens. In South America, the loss of productivity related to these diseases has not yet been well explored. Objective: Estimate the potentially productive years of life lost (PPYLL) and loss of productivity related to premature mortality associated with CVD in South America, in 2019. Methods: Mortality data available from the 2019 Global Burden of Disease Study were used to estimate the burden of disease attributable to CVD. For monetary calculations of productivity loss, a proxy of the human capital approach was used. Data were stratified by sex, in working age groups. Results: The total number of deaths due to CVD in South America in 2019 was 754,324, and the total number of PPYLL was 2,040,973. The total permanent loss of productivity was approximately US$ 3.7 billion and US$ 7.8 billion in purchasing power parity, equivalent to 0.11% of the gross domestic product. The cost per death was US$ 22,904, and the ratio between men and women for the cost per death was 1.45. The variation in scenarios indicates that the estimates are robust, even with important differences between countries. Conclusions: CVD impose a significant economic burden on countries in South America. The characterization of this burden can support governments in the allocation of resources for the planning and execution of health policies and interventions in promotion, prevention, and recovery. Background (CVD burdens explored Objective (PPYLL Methods 201 sex groups Results 754324 754 324 754,324 2040973 2 040 973 2,040,973 US 37 3 7 3. 78 8 7. parity 011 0 11 0.11 product 22904 22 904 22,904 145 1 45 1.45 robust Conclusions promotion prevention recovery 20 75432 75 32 754,32 204097 04 97 2,040,97 01 0.1 2290 90 22,90 14 4 1.4 7543 754,3 20409 9 2,040,9 0. 229 22,9 1. 754, 2040 2,040, 22, 204 2,040 2,04 2,0 2,

Resumo Fundamento: As doenças cardiovasculares (DCV) têm ônus sanitário e econômico significativos. Na América do Sul (AS), a perda de produtividade relacionada a estas enfermidades ainda não foi bem explorada. Objetivo: Estimar os anos de vida produtiva perdidos (AVPP) e a perda de produtividade relacionados a mortalidade prematura associada as DCV na AS, em 2019. Métodos: Empregou-se dados de mortalidade disponíveis no Global Burden of Disease Study 2019 na estimativa da carga de doença atribuível a DCV. Para os cálculos monetários da perda da produtividade usou-se uma proxy da abordagem de capital humano. Estratificou-se por sexo, nas faixas etárias de trabalho. Resultados: O número total de mortes por DCV na AS no ano de 2019 foi de 754.324 e os AVPP foram 2.040.973. A perda permanente de produtividade total foi de aproximadamente US$ 3,7 bilhões e US$ 7,8 bilhões em paridade do poder de compra, equivalente a 0,11% do produto interno bruto. O custo por morte foi de US$ 22.904, e a razão desse custo por óbito, entre homens e mulheres foi 1,45. A variação dos cenários aponta robustez nas estimativas, mesmo com diferenças importantes entre os países. Conclusões: As DCV impõem um ônus econômico significativo a este bloco de países. A caracterização deste fardo pode amparar os governos na alocação de recursos destinados ao planejamento e execução de políticas e intervenções sanitárias, sejam de promoção, prevenção ou recuperação. Fundamento (DCV significativos , (AS) explorada Objetivo (AVPP Métodos Empregouse Empregou se 201 usouse usou humano Estratificouse Estratificou sexo trabalho Resultados 754324 754 324 754.32 2040973 2 040 973 2.040.973 US 37 3 7 3, 78 8 7, compra 011 0 11 0,11 bruto 22904 22 904 22.904 óbito 145 1 45 1,45 estimativas países Conclusões sanitárias promoção recuperação (AS 20 75432 75 32 754.3 204097 04 97 2.040.97 01 0,1 2290 90 22.90 14 4 1,4 7543 754. 20409 9 2.040.9 0, 229 22.9 1, 2040 2.040. 22. 204 2.040 2.04 2.0 2.

ABSTRACT This experiment was carried out to evaluate the effects of organic acids on the intestinal integrity and productive performance of broiler chickens experimentally inoculated with Salmonella Enteritidis. Additionally, Salmonella colonization levels in internal organs were evaluated. The study included 576 one-day-old CobbTM male broilers, distributed into eight treatment groups and six replicates. A completely randomized experimental design (encapsulated butyric acid × inoculation by Salmonella Enteritidis) was used. Poultry was orally inoculated with Salmonella Enteritidis in the first day (0 or 2.0 × 106 CFU/mL) and after 22 days of age (0 or 1.0 × 109 CFU/ mL). The butyric acid was added to the feed in different concentration (treatments 0.03, 0.075, and 0.15%), and the chickens were raised up to 42 days old. Encapsulated butyric acid at 0.03% increased the body weight gain and the average weight of the chickens up to 21 days old. After 14 days old, the butyric acid had a positive effect on jejunum villus. Encapsulated butyric acid at 0.03% in feed improves the performance and intestinal integrity of chickens. Additionally evaluated 57 onedayold one old broilers replicates encapsulated used 0 ( 20 2 2. 10 CFU/mL CFUmL CFU mL 1 1. mL. . mL) treatments 003 03 0.03 0075 075 0.075 0.15%, 015 0.15% , 15 0.15%) 4 villus 5 00 0.0 007 07 0.07 01 0.15 0. 0.1

Abstract Introduction: Academic Leagues (ALs) are not-for-profit groups commonly organized by graduate students and advisors in Brazilian universities, that follow the principles of the academic triad (teaching, research, and service). Historically found in medical schools, they have also been widespread in several health courses. However, knowledge about ALs is limited. Objectives: To conduct a systematic review on academic health leagues in Brazil, analyze the demographic profile and performance of ALs in Brazil, proposing concomitantly a checklist guide for the writing of experience reports on the subject. Methods: The study consists of a systematic review following the PRISMA guidelines and using the BVS Health and Medline databases. Details of ALs, their historical evolution, demographic profile, and bibliometric evaluation of the obtained data were described. In addition, a checklist was developed to guide new reports on AL experiences. Results: A total of 2,064 studies were selected, with 74 articles included in 20 years of analysis (2003-2022). The profile of health ALs has changed over the years, reaching the current model based on the triad of activities. However, ALs are heterogeneous in Brazil, concentrated in some regions, especially in the Southeast. Moreover, the heterogeneity of the studies, absence of a central scientific journal, and lack of quantitative uni/multicentric studies that assess the impact of ALs on student education were observed. Conclusion: New studies within this theme are still necessary to clarify the activities developed and their academic and social impacts. Introduction (ALs notforprofit not profit universities teaching, teaching (teaching research service. service . service) schools courses However limited Objectives Brazil subject Methods databases evolution described addition experiences Results 2064 2 064 2,06 selected 7 20032022. 20032022 2003 2022 (2003-2022) regions Southeast Moreover journal unimulticentric uni multicentric observed Conclusion impacts 206 06 2,0 2003202 200 202 (2003-2022 0 2, 200320 (2003-202 20032 (2003-20 (2003-2 (2003- (2003 (200 (20 (2 (

Resumo Introdução: As ligas acadêmicas (LA) são grupos organizados sem fins lucrativos que seguem os princípios do trinômio universitário (ensino, pesquisa e extensão) por discentes e profissionais orientadores, historicamente presentes em faculdades de Medicina, mas também difundidas em diversos cursos de saúde. No entanto, o conhecimento sobre as LA é limitado. Objetivo: Este estudo teve como objetivos realizar uma revisão sistemática sobre as LA de saúde no Brasil, analisar o perfil demográfico e atuação delas no país, e propor concomitantemente um checklist norteador para a redação de relatos de experiência sobre a temática. Método: O estudo consiste em uma revisão sistemática que adotou as orientações do PRISMA e utilizou como banco de dados a BVS e Medline. Realizaram-se a descrição de detalhes das LA, a evolução histórica, o perfil demográfico e a avaliação bibliométrica dos dados obtidos. Além disso, elaborou-se um checklist (Crelas) para orientar novos relatos de experiência de LA. Resultado: Foram selecionados 2.064 estudos, e incluíram-se 74 artigos em 20 anos de análise (2003-2022). O perfil das LA em saúde se alterou com o passar dos anos, chegando ao modelo atual pautado no tripé de atividades. Ainda assim, as LA são heterogêneas no país, concentradas em algumas regiões, especialmente no Sudeste. Ademais, observaram-se uma heterogeneidade dos estudos, ausência de uma revista central e carência de estudos quantitativos uni/multicêntricos que avaliassem o impacto das LA na formação dos estudantes. Conclusão: Ainda são necessários novos estudos sobre essa temática com o propósito de esclarecer a lacuna acerca das atividades desenvolvidas e seus impactos acadêmicos e sociais. Introdução (LA ensino, ensino (ensino extensão orientadores Medicina entanto limitado Objetivo Brasil país Método Medline Realizaramse Realizaram histórica obtidos disso elaborouse elaborou Crelas (Crelas Resultado 2064 2 064 2.06 incluíramse incluíram 7 20032022. 20032022 2003 2022 . (2003-2022) assim regiões Sudeste Ademais observaramse observaram unimulticêntricos uni multicêntricos estudantes Conclusão sociais 206 06 2.0 2003202 200 202 (2003-2022 0 2. 200320 (2003-202 20032 (2003-20 (2003-2 (2003- (2003 (200 (20 (2 (

Abstract The aim of this study was to assess temporal trends in the quality of health care during the first-week child check-up in primary care services stratified by municipal, health team and maternal characteristics. We conducted a cross-sectional study using data from the three cycles of the National Program for the Improvement of Access and Quality (PMAQ) (2012, 2014 and 2018). Adult service users with children aged up to 2 were interviewed. The outcome was “good quality health care in the first week of life”. Descriptive and time trend analyses were performed using variance-weighted least squares regression. The frequency of good quality care during the first-week check-up was 47.9% (95%CI 46.6-49.3) in 2012, 52.5% (95%CI 51.3-53.7) in 2014 and 53.3% (95%CI 52.2-54.4) in 2018, with an annual increase of 0.73 pp (p<0.001). The annual increase was greater in the Northeast (2.06 pp) and in municipalities with very low/low HDI (1.48 pp) and 100% family health strategy coverage (0.98 pp). Trends in the frequency of good quality health care during the first-week child check-up were favorable. firstweek checkup check municipal characteristics crosssectional cross sectional PMAQ (PMAQ 2012 (2012 201 2018. 2018 . 2018) interviewed life. life life” varianceweighted variance weighted regression 479 47 9 47.9 95%CI 95CI CI 95 46.649.3 466493 46.6 49.3 46 6 49 3 46.6-49.3 525 52 5 52.5 51.353.7 513537 51.3 53.7 51 53 7 51.3-53.7 533 53.3 52.254.4 522544 52.2 54.4 54 4 52.2-54.4 073 0 73 0.7 p<0.001. p0001 p p<0.001 001 (p<0.001) 2.06 206 06 (2.0 lowlow low 1.48 148 1 48 (1.4 100 0.98 098 98 (0.9 pp. favorable (201 20 47. 649 46.649. 46649 466 46. 493 49. 46.6-49. 52. 353 51.353. 51353 513 51. 537 53. 51.3-53. 254 52.254. 52254 522 544 54. 52.2-54. 07 0. p000 p<0.00 00 (p<0.001 2.0 (2. 1.4 14 (1. 10 0.9 09 (0. (20 64 46.649 4664 46.6-49 35 51.353 5135 51.3-53 25 52.254 5225 52.2-54 p00 p<0.0 (p<0.00 2. (2 1. (1 (0 46.64 46.6-4 51.35 51.3-5 52.25 52.2-5 p0 p<0. (p<0.0 ( 46.6- 51.3- 52.2- p<0 (p<0. p< (p<0 (p< (p

Resumo O objetivo deste estudo foi avaliar a tendência temporal da qualidade da atenção à saúde da criança na consulta da primeira semana de vida no nível da Atenção Primária à Saúde, segundo características dos municípios, do processo de trabalho das equipes e das usuárias responsáveis pelas crianças. Foram realizadas análises transversais com dados dos três ciclos do Programa Nacional de Melhoria do Acesso e da Qualidade (PMAQ) (2012, 2014 e 2018). Usuárias adultas com filhos de até dois anos foram entrevistadas. O desfecho foi a “boa qualidade da atenção à saúde na primeira semana de vida”. Foram realizadas análises descritivas e de tendência temporal por meio de regressão de mínimos quadrados ponderados por variância. A frequência de boa qualidade na consulta da primeira semana de vida foi 47,9% (IC95% 46,6-49,3) em 2012, 52,5% (IC95% 51,3-53,7) em 2014 e 53,3% (IC95% 52,2-54,4) em 2018, com um aumento anual de 0,73 ponto percentual (p<0,001). O aumento anual foi maior na região Nordeste (2,06 pp) e com IDH muito baixo/baixo (1,48 pp) e com 100% de cobertura de ESF (0,98 pp). Ao longo dos três ciclos do PMAQ-AB houve uma evolução favorável na frequência da boa qualidade na atenção à saúde na primeira semana de vida. Saúde municípios crianças PMAQ (PMAQ 2012 (2012 201 2018. 2018 . 2018) entrevistadas vida” variância 479 47 9 47,9 IC95% IC95 IC (IC95 46,649,3 466493 46,6 49,3 46 6 49 3 46,6-49,3 525 52 5 52,5 51,353,7 513537 51,3 53,7 51 53 7 51,3-53,7 533 53,3 52,254,4 522544 52,2 54,4 2 54 4 52,2-54,4 073 0 73 0,7 p<0,001. p0001 p p<0,001 001 (p<0,001) 2,06 206 06 (2,0 pp baixobaixo baixo 1,48 148 1 48 (1,4 100 0,98 098 98 (0,9 pp. PMAQAB AB (201 20 47, IC9 (IC9 649 46,649, 46649 466 46, 493 49, 46,6-49, 52, 353 51,353, 51353 513 51, 537 53, 51,3-53, 254 52,254, 52254 522 544 54, 52,2-54, 07 0, p000 p<0,00 00 (p<0,001 2,0 (2, 1,4 14 (1, 10 0,9 09 (0, (20 (IC 64 46,649 4664 46,6-49 35 51,353 5135 51,3-53 25 52,254 5225 52,2-54 p00 p<0,0 (p<0,00 2, (2 1, (1 (0 46,64 46,6-4 51,35 51,3-5 52,25 52,2-5 p0 p<0, (p<0,0 ( 46,6- 51,3- 52,2- p<0 (p<0, p< (p<0 (p< (p

ABSTRACT Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and to explore the potential correlations between parameters of QoL and clinical indices. Subjects and methods: We enrolled a total of 109 patients with craniopharyngioma. We utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Questionnaire Depression (PHQ9) and Pittsburgh Sleep Quality Index to prospectively evaluated their QoL. Parameters of QoL along with clinical indices were compared among sub-groups divided according to Puget classification. Correlation analyses and regression analyses were performed to detect influential determinants to self-reported wellness. Results: Patients presented impaired QoL compared with general population ( p < 0.001), as assessed by SF-36. Correlation analyses indicated the detrimental influence resulting from central diabetes insipidus (CDI). Multivariate linear regression unveiled the adverse effect of CDI on Mental Component Summary (coefficient = −13.869, p = 0.007), GAD7 total score (coefficient = 2.072, p = 0.049) as well as PHQ9 total score (coefficient = 3.721, p = 0.001). Multivariate logistic regression verified CDI as a risk factor of developing depressive symptoms (OR = 6.160, p = 0.001). Conclusion: QoL of patients with craniopharyngioma was remarkably compromised before operation. CDI exerted detrimental influences on patients’ QoL and it might serve as a marker for early identification of patients at risk of depression. Objective (QoL oncology preoperative pre operative methods 10 3 SF36, SF36 SF , (SF-36) List90, List90 List 90, 90 List-90 GAD7, GAD (GAD7) PHQ (PHQ9 subgroups sub groups classification selfreported self reported wellness Results 0.001, 0001 0.001 0 001 0.001) SF36. 36. SF-36 CDI. . (CDI) coefficient 13869 13 869 −13.869 0.007, 0007 0.007 007 0.007) 2072 2 072 2.072 0.049 0049 049 3721 721 3.721 0.001. OR 6160 6 160 6.160 Conclusion operation depression 1 SF3 (SF-36 List9 9 List-9 (GAD7 (PHQ 000 0.00 00 SF-3 (CDI 1386 86 −13.86 207 07 2.07 0.04 004 04 372 72 3.72 616 16 6.16 (SF-3 List- (GAD 0.0 SF- 138 8 −13.8 20 2.0 37 7 3.7 61 6.1 (SF- 0. −13. 2. 3. 6. (SF −13 −1 −

ABSTRACT Objective: To verify the COVID-19 clinical characteristics, associated comorbidities, and outcomes in adolescents. Data source: This is a systematic review study based on articles published between 2020 and 2022 in the United States National Library of Medicine - PubMed (MedLine), Virtual Health Library – VHL (LILACS), Science Direct, Web of Science, and Scopus (Elsevier) databases. The study was registered in the International Prospective Register of Systematic Reviews, under No. CRD42022309108. Data synthesis: A total of 1188 studies were identified. After applying the selection criteria, 13 articles were included. Prevalence was 25%; mild cases were predominant; and fever, cough, headache, anosmia, nasal congestion, and ageusia were frequent. Fever and cough were proportionally higher in hospitalized cases: 81 and 68%, respectively. Dyspnea (odds ratio [OR] 6.3; confidence interval 95%[CI] 2.8–14.3), fever (OR 3.8; 95%CI 2.0–7.4), and cough (OR 3.4; 95%CI 2.0–6.0) were associated with severe cases. Up to 28% required intensive care and 38% required mechanical ventilation. Pre-existing comorbidities increased the risk of hospitalization and death. Severe cases were associated with the risk of death (relative risk [RR] 4.6; 95%CI 2.8–7.5). The black, mixed, and indigenous races/skin colors represented risk groups, as well as residents of poorer regions. Conclusions: The review provided a better understanding of the disease profile and may favor the development of public policies, in addition to contributing to the current literature in the field of adolescent health. Objective COVID19 COVID 19 COVID-1 characteristics adolescents source 202 MedLine, MedLine , (MedLine) LILACS, LILACS (LILACS) Direct Elsevier (Elsevier databases Reviews No CRD42022309108 CRD synthesis 118 identified criteria 1 included 25% 25 predominant headache anosmia congestion frequent 8 68 68% respectively odds OR [OR 6.3 63 6 3 95CI CI 95% 95 95%[CI 2.8–14.3, 28143 2.8–14.3 2 14 2.8–14.3) 3.8 38 2.0–7.4, 2074 2.0–7.4 0 7 4 2.0–7.4) 3.4 34 2.0–6.0 2060 28 ventilation Preexisting Pre existing relative RR [RR 4.6 46 2.8–7.5. 2875 2.8–7.5 . 5 2.8–7.5) black mixed racesskin races skin groups regions Conclusions policies health COVID1 COVID- 20 (MedLine (LILACS CRD4202230910 11 6. 9 2814 2.8–14. 3. 207 2.0–7. 2.0–6. 206 4. 287 2.8–7. CRD420223091 281 2.8–14 2.0–7 2.0–6 2.8–7 CRD42022309 2.8–1 2.0– 2.8– CRD4202230 2.0 2.8 CRD420223 2. CRD42022 CRD4202 CRD420 CRD42 CRD4

RESUMO Objetivo: Verificar as características clínicas, as comorbidades associadas e os desfechos da COVID-19 em adolescentes. Fontes de dados: Trata-se de uma revisão sistemática elaborada com base em artigos publicados entre 2020 e 2022 nas bases de dados United States National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS), Science Direct, Web of Science e Scopus. O estudo foi registrado no International Prospective Register of Systematic Reviews, n° CRD42022309108. Síntese dos dados: Foram identificados 1.188 estudos. Após a aplicação dos critérios de seleção, 13 artigos foram incluídos. A prevalência foi de 25%; os casos leves foram predominantes; e febre, tosse, cefaleia, anosmia, congestão nasal e ageusia foram frequentes. Febre e tosse foram proporcionalmente maiores em casos hospitalizados, com 81 e 68%, respectivamente. Dispneia (OR 6,3; IC95% 2,8–14,3), febre (OR 3,8; IC95% 2,0–7,4) e tosse (OR 3,4; IC95% 2,0–6,0) foram associados a casos graves. Até 28% necessitaram de cuidados intensivos e 38% de ventilação mecânica. A preexistência de comorbidade aumentou o risco de internação e óbito. Os casos graves estão associados ao risco de óbito (risco relativo — RR 4,6; IC95% 2,8–7,5). As raças/cores preta, parda e indígena e os moradores de regiões mais pobres foram grupo de risco. Conclusões: A revisão permitiu conhecer o perfil da doença e poderá favorecer a elaboração de políticas públicas, além de contribuir para a literatura atual no campo da saúde do adolescente. Objetivo clínicas COVID19 COVID 19 COVID-1 adolescentes Tratase Trata se 202 PubMed, PubMed , (PubMed) BVS, BVS (BVS) Direct Scopus Reviews n CRD42022309108 CRD 1188 1 188 1.18 estudos seleção incluídos 25% 25 predominantes cefaleia anosmia frequentes hospitalizados 8 68 68% respectivamente OR 6,3 63 6 3 IC95 IC 2,8–14,3, 28143 2,8–14,3 2 14 2,8–14,3) 3,8 38 2,0–7,4 2074 0 7 4 3,4 34 2,0–6,0 2060 28 mecânica 4,6 46 2,8–7,5. 2875 2,8–7,5 . 5 2,8–7,5) raçascores raças cores preta Conclusões públicas adolescente COVID1 COVID- 20 (PubMed (BVS CRD4202230910 118 18 1.1 6, IC9 2814 2,8–14, 3, 2,0–7, 207 2,0–6, 206 4, 287 2,8–7, CRD420223091 11 1. 281 2,8–14 2,0–7 2,0–6 2,8–7 CRD42022309 2,8–1 2,0– 2,8– CRD4202230 2,0 2,8 CRD420223 2, CRD42022 CRD4202 CRD420 CRD42 CRD4

Abstract Background The COVID-19 pandemic has triggered crises in the public health sector that have complex and multifaceted interrelationships with antimicrobial resistance. It is important to evaluate the impact of COVID-19 on microbiological profile, antibiotic and alcohol gel consumption in Intensive Care Units (ICU). Methods This is a retrospective study undertaken in an infectious disease hospital located in Bahia/Brazil during three periods: from March 2019 to February 2020; from March 2020 to February 2021; and from March 2021 to February 2022. It was evaluated the incidence density of Candida spp and of multidrug-resistant Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE group) in blood, urine and tracheal secretion isolated 48 h after the patient's admission to the ICU, as well as the use of alcohol gel (in milliliters) and consumption of antibiotics in Defined Daily Dose (DDD) per 1,000 ICU patient-days in the previous year and in the first two years of COVID-19 pandemic. Results There was an increase in Candida spp. (5.81, p < 0.001, IRR = 10.47, 95 % CI 2.57‒42.62) and in carbapenem-resistant A. baumannii in clinical cultures (4.71, p < 0.001, IRR = 8.46, 95 % CI 2.07‒34.60), the latter mainly in tracheal secretions (3.18, p =0.02, IRR = 11.47, 95 % CI 1.58‒83.39). A rise in the consumption of ceftriaxone and piperacillin-tazobactam, along with an increase in the utilization of alcohol gel were observed. Conclusion The shifting microbiological profile can be attributed to both the unique characteristics of patients with COVID-19 and the adjustments made to healthcare facilities' structural and work routines. Understanding these changes is essential in addressing the accelerated impact of antimicrobial resistance during the pandemic. Therefore, conducting thorough reviews of institutional practices and routines becomes critical in mitigating the consequences of antimicrobial resistance and its implications for patient care. COVID19 COVID 19 COVID-1 ICU. . (ICU) BahiaBrazil Bahia Brazil periods 201 202 2022 multidrugresistant multidrug resistant faecium aureus pneumoniae aeruginosa ESKAPE group blood 4 s milliliters DDD (DDD 1000 1 000 1,00 patientdays days 5.81, 581 5 81 (5.81 0001 0 001 0.001 1047 10 47 10.47 9 2.57‒42.62 2574262 2 57 42 62 carbapenemresistant carbapenem 4.71, 471 71 (4.71 846 8 46 8.46 2.07‒34.60, 2073460 2.07‒34.60 , 07 34 60 2.07‒34.60) 3.18, 318 3 18 (3.18 002 02 =0.02 1147 11 11.47 1.58‒83.39. 1588339 1.58‒83.39 58 83 39 1.58‒83.39) piperacillintazobactam, piperacillintazobactam piperacillin tazobactam, tazobactam piperacillin-tazobactam observed facilities Therefore care COVID1 COVID- (ICU 20 100 00 1,0 5.81 (5.8 0.00 104 10.4 2.57‒42.6 257426 6 4.71 7 (4.7 84 8.4 207346 2.07‒34.6 3.18 31 (3.1 =0.0 114 11.4 158833 1.58‒83.3 1, 5.8 (5. 0.0 10. 2.57‒42. 25742 4.7 (4. 8. 20734 2.07‒34. 3.1 (3. =0. 11. 15883 1.58‒83. 5. (5 0. 2.57‒42 2574 4. (4 2073 2.07‒34 3. (3 =0 1588 1.58‒83 ( 2.57‒4 257 207 2.07‒3 158 1.58‒8 2.57‒ 25 2.07‒ 15 1.58‒ 2.57 2.07 1.58 2.5 2.0 1.5 2. 1.

Aim The study aimed to evaluate the association between oral health and academic performance and/or school absenteeism. Methods Electronic searches were performed of the PubMed, Web of Science, SCOPUS and LILACS/BVS databases. We included observational studies that evaluated the association between dental caries, tooth loss, dental pain or oral health status with school absenteeism or academic performance. The studies had to contain a representative sample of the population: schoolchildren, children or adolescents. After the removal of duplicates, the electronic searches produced 3,789 articles. Of these, 25 studies were included in the systematic review and 13 in the meta-analysis. Results Considering all the studies evaluated in the meta-analysis, seven articles satisfied 100% of the Joanna Briggs Institute Critical Appraisal checklist, and six contained between 90% and 75% positive answers. The pooled effects showed that the chances of school absenteeism were 31% higher in subjects with dental caries (OR 1.31; 95%CI 1.12-1.54). Students with fair/poor dental health had a 50% higher chance of suffering poor academic performance (OR 1.50; 95%CI 1.22-1.84) and 34% higher chance of having problems at school (OR 1.34; 95%CI 1.06-1.70). Students with a history of toothache had a 3.7 higher chance of being absent from school (OR 6.65; 95%CI 1.60-8.32) and 71% higher chance of missing class due to toothache (OR 1.71; 95%CI 1.15-2.56). Subjects with a history of toothache had a 2.5 times higher chance of suffering poor academic performance (OR 2.58; 95% CI 2.04-3.27). Conclusion Therefore, students with oral problems were more likely to take time off school and present inferior academic performance. andor PubMed Science LILACSBVS LILACS BVS databases loss population schoolchildren adolescents duplicates 3789 3 789 3,78 these 2 1 metaanalysis. metaanalysis meta analysis. analysis meta-analysis metaanalysis, analysis, 100 checklist 90 75 answers 31 OR 1.31 131 95CI 95 1.121.54. 112154 1.12 1.54 . 12 54 1.12-1.54) fairpoor fair 50 1.50 150 1.221.84 122184 1.22 1.84 22 84 1.22-1.84 34 1.34 134 1.061.70. 106170 1.06 1.70 06 70 1.06-1.70) 37 7 3. 6.65 665 6 65 1.608.32 160832 1.60 8.32 60 8 32 1.60-8.32 71 1.71 171 1.152.56. 115256 1.15 2.56 15 56 1.15-2.56) 5 2. 2.58 258 58 2.043.27. 204327 2.04 3.27 04 27 2.04-3.27) Therefore 378 78 3,7 10 9 1.3 121 1.121.54 11215 112 1.1 154 1.5 1.12-1.54 221 1.221.8 12218 122 1.2 184 1.8 1.22-1.8 061 1.061.70 10617 106 1.0 170 1.7 0 1.06-1.70 6.6 66 608 1.608.3 16083 160 1.6 832 8.3 1.60-8.3 17 152 1.152.56 11525 115 256 1.15-2.56 043 2.043.27 20432 204 2.0 327 3.2 2.04-3.27 3, 1. 1.121.5 1121 11 1.12-1.5 1.221. 1221 18 1.22-1. 1.061.7 1061 1.06-1.7 6. 1.608. 1608 16 83 8. 1.60-8. 1.152.5 1152 1.15-2.5 2.043.2 2043 20 2.04-3.2 1.121. 1.12-1. 1.221 1.22-1 1.061. 1.06-1. 1.608 1.60-8 1.152. 1.15-2. 2.043. 2.04-3. 1.121 1.12-1 1.22- 1.061 1.06-1 1.60- 1.152 1.15-2 2.043 2.04-3 1.12- 1.06- 1.15- 2.04-