Resumo Neste artigo é analisado o discurso produzido pelos generais das Forças Militares e pelas vozes de máxima autoridade política na extinta guerrilha das FARC-EP, que hoje se transformou no partido político Comunes. Por meio de 21 entrevistas em profundidade com atores principais são comparadas as formas opostas de legitimar, problematizar e entender o alcance e significado, tanto do Acordo de Paz assinado em novembro de 2016, quanto de sua subsequente implementação. Assim, tanto o estamento militar quanto a guerrilha desmobilizada projetam um discurso irreconciliável. Embora compartilhem um diagnóstico de descumprimento desse Acordo, as responsabilidades e acusações seguem trajetórias muito diferentes, o que reflete a situação de grande polarização e enfraquecimento do processo de paz experimentado nos últimos anos. FARCEP, FARCEP FARC EP, EP FARC-EP Comunes 2 legitimar significado 2016 implementação Assim irreconciliável diferentes anos 201 20

Resumen El siguiente trabajo analiza el discurso producido por generales de las Fuerzas Militares y voces de máxima autoridad política en la extinta guerrilla de las FARC-EP, transformada hoy en el partido político Comunes. A través de 21 entrevistas en profundidad con actores protagonistas se contrastan las formas opuestas de legitimar, problematizar y entender el alcance y significado, tanto del Acuerdo de Paz suscrito en noviembre de 2016, como de su posterior implementación. Así, tanto el estamento militar como la desmovilizada guerrilla proyectan un discurso irreconciliable. Si bien comparten un diagnóstico de incumplimiento a dicho Acuerdo, las responsabilidades y acusaciones discurren por trayectorias muy diferentes, lo cual refleja la situación de gran polaridad y el debilitamiento del proceso de paz experimentado en los últimos años. FARCEP, FARCEP FARC EP, EP FARC-EP Comunes 2 legitimar significado 2016 implementación Así irreconciliable diferentes años 201 20

Abstract The following work analyzes the discourse produced by generals of the Colombian Armed Forces and voices of the highest political authority in the now-defunct Revolutionary Armed Forces of Colombia (FARC-EP) guerrilla, which has transformed into the political party Comunes. To this end, this article analyzes the contrasting ways of legitimizing, problematizing, and understanding the scope and significance of the Peace Agreement signed in November 2016 and its subsequent implementation are examined through 21 in-depth interviews with key actors. Thus, the military establishment and the demobilized guerrilla project an irreconcilable discourse. While they share a diagnosis of non-compliance with the Agreement, the responsibilities and accusations follow very different trajectories, reflecting the great polarity and the weakening of the peace process experienced in recent years. nowdefunct now defunct FARCEP FARC EP (FARC-EP Comunes end legitimizing problematizing 201 2 indepth depth actors Thus noncompliance non compliance trajectories years 20

Résumé Le présent travail analyse le discours produit par les généraux des Forces Militaires et les voix des plus hautes autorités politiques de l’ancienne guérilla des FARC-EP, aujourd’hui transformée en le parti politique Comunes. À travers 21 entretiens approfondis avec des acteurs clés, les formes opposées de légitimation, de problématisation et de compréhension de la portée et de la signification de l’Accord de Paix signé en novembre 2016, ainsi que de sa mise en œuvre ultérieure, sont mises en contraste. De cette façon, tant l’institution militaire que la guérilla démobilisée projettent un discours irréconciliable. Bien qu’ils partagent un diagnostic de non-respect de cet Accord, les responsabilités et les accusations suivent des trajectoires très différentes, reflétant la situation de grande polarisation et l’affaiblissement du processus de paix observé ces dernières années. lancienne l ancienne FARCEP, FARCEP FARC EP, EP FARC-EP aujourdhui aujourd hui Comunes 2 clés légitimation lAccord Accord 2016 ultérieure contraste façon linstitution institution irréconciliable quils qu ils nonrespect non respect différentes laffaiblissement affaiblissement années 201 20

SUMMARY: In current study, we used Nissl staining to examine the histological structure of the juvenile Chinese alligator brain, and immunohistochemistry (IHC) staining to detail the serotonin (5-hydroxytryptamine, 5-HT) localization and morphology of neurons belonging to the serotonergic system. Nissl staining revealed that the Chinese alligator brain was divided into four regions (telencephalon, diencephalon, brainstem, and cerebellum) and a connected ventricular system (containing the pair of lateral ventricles, third ventricle, fourth ventricle and the aqueduct). According to the IHC results, 5-HT immunoreactive (5-HT-IR) neurons were primarily observed in the cerebral cortex, the hypothalamic paraventricular nucleus (PH), tectum and tegmentum of the optic lobes, the medial longitudinal fasciculus (Flm) of medulla oblongata and the cerebellar cortex. 5-HT-IR fibers were mostly located lateral to the hypothalamic paraventricular nucleus (PH), in the medial vestibular nucleus (MVe) of the medulla oblongata, and in the choroid plexus (CP) of the lateral ventricles. Additionally, our findings paralleled those results of other reptiles; nevertheless, some distinctions in terms of both histological architecture and function were identified. The layering of the cerebral cortex and tectum, as well as the arrangement of Purkinje cells, differed between reptile brains. The distribution of 5-HT-IR neurons varied in the layer of cerebral and cerebellar cortex when compared to other reptiles. Within the diencephalon, 5-HT-IR neurons formed distinct nuclei in the hypothalamic paraventricular nucleus (PH), but few in the infundibular recess.

RESUMEN: Utilizamos la tinción de Nissl para examinar la estructura histológica del cerebro juvenil del caimán chino y la tinción inmunohistoquímica (IHC) para detallar la localización y morfología de la serotonina (5-hidroxitriptamina, 5-HT) de las neuronas que pertenecen al sistema serotoninérgico. La tinción de Nissl reveló que el cerebro del caimán chino estaba dividido en cuatro regiones (telencéfalo, diencéfalo, tronco encefálico y cerebelo) y un sistema ventricular conectado (que contiene el par de ventrículos laterales, el tercer ventrículo, el cuarto ventrículo y el acueducto). Según los resultados de IHC, las neuronas inmunorreactivas 5-HT (5-HT-IR) se observaron principalmente en la corteza cerebral, el núcleo paraventricular (PH) hipotalámico, el tectum y tegmento de los lóbulos ópticos, el fascículo longitudinal medial (Flm) de médula oblonga y la corteza cerebelosa. Las fibras 5-HT-IR se ubicaron principalmente lateral al núcleo paraventricular (PH) hipotalámico, en el núcleo vestibular medial (MVe) de la médula oblonga y en el plexo coroideo (CP) de los ventrículos laterales. Además, nuestros hallazgos fueron semejantes a los resultados obtenidos de otros reptiles; sin embargo, se identificaron algunas distinciones en términos tanto de arquitectura histológica como de función. Las capas de la corteza cerebral y el tectum, así como la disposición de las neuronas purkinjenses, diferían entre los cerebros de los reptiles. La distribución de las neuronas 5-HT-IR varió en la capa de la corteza cerebral y cerebelosa en comparación con otros reptiles. Dentro del diencéfalo, las neuronas 5-HT-IR formaron núcleos distintos en el núcleo paraventricular (PH) hipotalámico, pero pocos en el receso infundibular.

In this study, the typical azo dye methyl orange (MO) was degraded by pyrite (FeS2) activated by hydrogen peroxide (H2O2). When [MO] = 0.1 mM, [FeSJ = 2.0 g/L and [H2O2] = 22 mM, 96.4% MO was removed in 120 min and the TOC removal rate was higher than 50%. HO* was the primary radical responsible for MO degradation, in addition, the acid condition promoted the degradation of MO in the FeS2/H2O2 system. MO in tap water and river water was not effectively degraded, whereas acidification could weaken the inhibitory effect on the FeS2/ H2O2 system to enable the degradation of MO in tap and river water. The OD600 indicated that the solution was environmentally friendly after the reaction, and three degradation pathways of MO were discussed. In summary, Fe(ll) could be dissolved from FeS2, which activated H2O2 to generate Fe(lll) and HO*. FeS2 could reduce Fe(lll) into Fe(ll), thus realizing the Fe(lll)/(ll) cycle and efficiently activating H2O2 to degrade MO.

SUMMARY: The aim of this study was to compare the clinical value of vertebral artery ultrasound (VAU), Magnetic Resonance Angiography (MRA) and Digital Subtraction Angiography (DSA) on vertebral artery stenosis in patients with posterior circulation ischemia. Seventy-three patients with posterior circulation ischemia underwent vertebral artery ultrasound and magnetic resonance angiography as well as digital subtraction angiography, and the diagnosis of vertebral artery stenosis (VAS) and the degree of stenosis (normal, mild stenosis, moderate stenosis, severe stenosis, and occlusion) were recorded and compared between digital subtraction angiogram and vertebral artery ultrasound and magnetic resonance angiography. The vertebral artery stenosis rates on digital subtraction angiography and vertebral artery ultrasound were 87.30 % (55/63) and 49.20 % (31/63), respectively, and the difference was statistically significant. The rates of vertebral artery stenosis on digital subtraction angiography and, magnetic resonance angiography was 90.38 % (47/52) and 88.46 % (46/ 52), respectively, and the differences was not statistically significant. The sensitivity, accuracy, negative predictive value, and positive predictive value of vertebral artery ultrasound in diagnosing vertebral artery stenosis were 51.35 %, 54.76 %, 18.18 %, and 95.00 %, respectively, lower than those of magnetic resonance angiography, which were 91.89 %, 90.48 %, 57.14 %, and 97.14 %, respectively. Of the noninvasive imaging techniques, vertebral artery ultrasound does not accurately characterize vertebral artery stenosis and its degree of stenosis. Magnetic resonance angiography effectively screens for vertebral artery stenosis and its degree of stenosis, and can be used as a reliable tool for vertebral artery stenosis in posterior circulation cerebral infarction, and can be used in conjunction with digital subtraction angiogram in order to improve diagnostic convenience and accuracy.

RESUMEN: El objetivo de este estudio fue comparar el valor clínico de la ecografía de la arteria vertebral (VAU), la angiografía por resonancia magnética (ARM) y la angiografía por sustracción digital (DSA) en la estenosis de la arteria vertebral en pacientes con isquemia de la circulación posterior. A 73 pacientes con isquemia de la circulación posterior se les realizó una ecografía de la arteria vertebral y una angiografía por resonancia magnética, así como una angiografía por sustracción digital, y se les diagnosticó estenosis de la arteria vertebral (EVA) y el grado de estenosis (normal, estenosis leve, estenosis moderada, estenosis grave, y oclusión) se registraron y compararon la angiografía por sustracción digital y la ecografía de la arteria vertebral y la angiografía por resonancia magnética. Las tasas de estenosis de la arteria vertebral en la angiografía por sustracción digital y la ecografía de la arteria vertebral fueron del 87,30 % (55/63) y del 49,20 % (31/63), respectivamente, y la diferencia fue estadísticamente significativa. Las tasas de estenosis de la arteria vertebral en la angiografía por sustracción digital y la angiografía por resonancia magnética fueron del 90,38 % (47/52) y del 88,46 % (46/52), respectivamente, y las diferencias no fueron estadísticamente significativas. La sensibilidad, precisión, valor predictivo negativo y valor predictivo positivo de la ecografía de la arteria vertebral en el diagnóstico de estenosis de la arteria vertebral fueron 51,35 %, 54,76 %, 18,18 % y 95,00 %, respectivamente, inferiores a los de la angiografía por resonancia magnética, que fueron 91,89 %, 90,48 %, 57,14 % y 97,14 %, respectivamente. De las técnicas de imagen no invasivas, la ecografía de la arteria vertebral no caracteriza con precisión la estenosis de la arteria vertebral y su grado de estenosis. La angiografía por resonancia magnética detecta eficazmente la estenosis de la arteria vertebral y su grado de estenosis, y puede usarse como una herramienta confiable para la estenosis de la arteria vertebral en el infarto cerebral de circulación posterior, y puede ser utilizada junto con la angiografía por sustracción digital para mejorar el diagnóstico y la exactitud.

ABSTRACT: Rhododendron fortune belongs to a scented Rhododendron species native to China, which produces fragrant flowers of great ornamental and environmental values for landscaping or indoor beautification. However, the scents in Rhododendron fortuneihave not yet been investigated, let alone the mechanism of the formation of these fragrance in the flowers. In this study, we measured the scents in terms of its volatile components and contents (VOC) in Rhododendron fortuneiat four different flowering stages and in different tissues of the plant by headspace solid-phase micro-extraction combined (HS-SPME) with gas chromatography-mass spectrometry (GC-MS). Then the characteristic aromatic values, which reflects the degree of scent perception by human, of each VOC in the plant was calculated according to its respective aromatic thresholds. Results showed that three main VOCs measured from highest to lowest are methyl benzoates, terpenes and fatty acid derivatives. Their content increased after the flower bud opening and reached the highest at half to full blossom. In a flower most VOC contents were measured in petals and only trace amount in other tissues such as stamen, pistil. A small amount of VOCs was determined in leaves as well.All aromatic values were almost corresponded to the contents of three main VOCs, indicating that the flower fragrance arises truly from these VOC components. S-adenosyl-L-methionine: benzoic acid carboxyl methyl transferase (BAMT) catalyzes the final step to form methyl benzoates. To understand the mechanism of the formation of this main type fragrance and its regulation, we firstly isolate a gene of RfBAMT from petal of Rhododendron fortuneiby using homologous cloning and RACE technology. The full length of its cDNA was 1383 bp，with an open reading frame of 1104 bp, encoding a total of 368 amino acids. The phylogenetic tree analysis showed that RfBAMT was the closest to the BSMT of Camellia japonica, belonging to methyltransferases family. Then we measured the expression level of RfBAMT again at four flower developmental stages and in different flower tissues and leaves. The results showed that the expression level of this gene was highly positively correlated with the emitted content of methyl benzoates in the flowering, implying that RfBAMT plays a pivotal role in the formation and regulation of methyl benzoates in Rhododendron fortune.Thisresearchshowed that the RfBAMT was cloned and identified in our study and its expression level was highly positively correlated with the emitted content of methyl benzoates in the flowers and leaves, which indicated this gene may play an important role on regulation of methyl benzoate synthesis in Rhododendron fortunei.

RESUMO: Rhododendron fortunei pertence a uma espécie de rododendro perfumada nativa da China, que produz flores perfumadas de grande valor ornamental e ambiental para paisagismo ou embelezamento de interiores. No entanto, os aromas em Rhododendron fortunei ainda não foram investigados, muito menos o mecanismo de formação dessas fragrâncias nas flores. Neste estudo, medimos os aromas em termos de seus componentes e conteúdos voláteis (VOC) em Rhododendron fortunei em quatro diferentes estágios de floração e em diferentes tecidos da planta por microextração em fase sólida headspace combinada com cromatografia gasosa-espectrometria de massa. Em seguida, foram calculados os valores aromáticos característicos, que refletem o grau de percepção olfativa pelo ser humano, de cada VOC na planta de acordo com seus respectivos limiares aromáticos. Os resultados mostraram que três COVs principais medidos do mais alto ao mais baixo são benzoatos de metila, terpenos e derivados de ácidos graxos. Seu conteúdo aumentou após a abertura do botão floral e atingiu o máximo na metade da floração total. Em uma flor, a maioria dos teores de COV foram medidos em pétalas e apenas traços em outros tecidos, como estame, pistilo. Uma pequena quantidade de COVs foi determinada nas folhas também. Todos os valores aromáticos foram quase correspondentes aos teores de três COVs principais, indicando que a fragrância da flor surge verdadeiramente desses componentes de COV. Para entender o mecanismo de formação deste tipo principal de fragrância e sua regulação, primeiramente isolamos um gene de RfBAMT da pétala de Rhododendron fortunei usando clonagem homóloga e tecnologia RACE. O comprimento total de seu cDNA era de 1383 bp, com um quadro de leitura aberto de 1104 bp, codificando um total de 368 aminoácidos. A análise da árvore filogenética mostrou que RfBAMT foi o mais próximo do BSMT de Camellia japonica, pertencente à família das metiltransferases. Em seguida, medimos o nível de expressão de RfBAMT novamente em quatro estágios de desenvolvimento da flor e em diferentes tecidos e folhas de flores. Os resultados mostraram que o nível de expressão deste gene foi altamente correlacionado positivamente com o conteúdo emitido de benzoatos de metila na floração, implicando que RfBAMT desempenha um papel fundamental na formação e regulação de benzoatos de metila em Rhododendron fortune foi clonado e identificado em nosso estudo e seu nível de expressão foi altamente correlacionado positivamente com o conteúdo emitido de benzoatos de metila nas flores e folhas, o que indicou que este gene pode desempenhar um papel importante na regulação da síntese de benzoato de metila em Rhododendron fortunei.

In hierdie studie is beoog om die S.I.E.W.G.-vraelys vir die assessering van elektroniese woordeboekgebruik (EW-gebruik) in die Chinese konteks aan te pas en te bevestig. Ses kundiges het die vraelys in Chinees vertaal en dit toe terugvertaal in Engels om die akkuraatheid daarvan te waarborg. Die Chinese weer-gawe is aan 518 deelnemers uitgedeel. 'n Faktoranalise het sewe faktore blootgelê wat van die oor-spronklike vier-faktorstruktuur afwyk. Bykomend tot faktore wat verband hou met EW-konvensies,-funksies, en strategiese vaardighede, het die studie addisionele faktore, insluitende leerdersvoor-bereiding en foutopsporing, aanvaarding en gebruikskonteks, bergingsformaat en voordele van EW, en EW-intekening, geidentifiseer. Hierdie bevindings verskaf 'n omvattende begrip van EW-gebruikstra-tegieê vanuit die perspektief van Chinese leerders wat beide leerders en opvoeders baat. Dié studie bevestig nie net die S.I.E.W.G. in die Chinese konteks nie, maar beklemtoon ook die belangrikheid van die uitbreiding van leerderstrategieê vir die effektiewe benutting van elektroniese woorde-boeke.

This study aimed to adapt and validate the S.I.E.D.U. questionnaire for assessing electronic dictionary (ED) use in the Chinese context. Six specialists translated the questionnaire into Chinese and then back-translated it into English to ensure accuracy. The Chinese version was administered to 518 participants. Factor analysis revealed seven factors, differing from the original four-factor structure. In addition to factors related to ED conventions, functions, and strategic skills, the study identified additional factors, including learners' preparation and troubleshooting, acceptance and usage context, storage format and advantages of ED, and ED subscription. These findings provide a comprehensive understanding of ED use strategies from the perspective of Chinese learners, benefiting both learners and educators. This study not only validates the S.I.E.D.U. in the Chinese context but also underscores the importance of enhancing learners' strategies for effectively utilizing electronic dictionaries.

Abstract Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the role of ERS in the anterior cingulate cortex (ACC) in NP and the effect of EA on ERS in the ACC have not yet been investigated. In this study, an NP model was established by chronic constriction injury (CCI) of the left sciatic nerve in rats, and mechanical and cold tests were used to evaluate behavioral hyperalgesia. The protein expression and distribution were evaluated using western blotting and immunofluorescence. The results showed that glucose-regulated protein 78 (BIP) and inositol-requiring enzyme 1α (IRE-1α) were co-localized in neurons in the ACC. After CCI, BIP, IRE-1α, and phosphorylation of IRE-1α were upregulated in the ACC. Intra-ACC administration of 4-PBA and Kira-6 attenuated pain hypersensitivity and downregulated phosphorylation of IRE-1α, while intraperitoneal injection of 4-PBA attenuated hyperalgesia and inhibited the activation of P38 and JNK in ACC. In contrast, ERS activation by intraperitoneal injection of tunicamycin induced behavioral hyperalgesia in naive rats. Furthermore, EA attenuated pain hypersensitivity and inhibited the CCI-induced overexpression of BIP and pIRE-1α. Taken together, these results demonstrate that EA attenuates NP by suppressing BIP- and IRE-1α-mediated ERS in the ACC. Our study presents novel evidence that ERS in the ACC is implicated in the development of NP and provides insights into the molecular mechanisms involved in the analgesic effect of EA.

Abstract Background Dermatomyositis (DM) is an infrequent disease subgroup of idiopathic inflammatory myopathies characterized by distinct skin lesions. However, high heterogeneity makes clinical diagnosis and treatment of DM very challenging. Objectives Unsupervised classification in DM patients and analysis of key factors related to clinical outcomes. Methods This retrospective study was conducted between 2017 and 2022 at the Department of Rheumatology, Xiangya Hospital, Central South University. 162 DM patients were enrolled for unsupervised hierarchical cluster analysis. In addition, we divided the clinical outcomes of DM patients into four subgroups: withdrawal, stabilization, aggravation, and death, and compared the clinical profiles amongst the subgroups. Results Out of 162 DM patients, three clusters were defined. Cluster 1 (n = 40) was mainly grouped by patients with prominent muscular involvement and mild Interstitial Lung Disease (ILD). Cluster 2 (n = 72) grouped patients with skin rash, anti-Melanoma Differentiation Associated protein 5 positive (anti-MDA5+), and Rapid Progressive Interstitial Lung Disease (RP-ILD). Cluster 3 (n = 50) grouped patients with the mildest symptoms. The proportion of death increased across the three clusters (cluster 3 < cluster 1 < cluster 2). Study limitations The number of cases was limited for the subsequent construction and validation of predictive models. We did not review all skin symptoms or pathological changes in detail. Conclusions We reclassified DM into three clusters with different risks for poor outcome based on diverse clinical profiles. Clinical serological testing and cluster analysis are necessary to help clinicians evaluate patients during follow-up and conduct phenotype-based personalized care in DM. (DM lesions However challenging 201 202 Rheumatology Hospital University 16 addition subgroups withdrawal stabilization aggravation defined n 40 ILD. ILD . (ILD) 72 rash antiMelanoma anti Melanoma antiMDA5+, antiMDA5 antiMDA MDA5+ , MDA5 MDA (anti-MDA5+) RPILD. RPILD RP (RP-ILD) 50 2. 2) models detail followup follow up phenotypebased phenotype 20 4 (ILD 7 antiMDA5+ (anti-MDA5+ (RP-ILD (anti-MDA5 (anti-MDA

Resumos A recuperação da esquizofrenia é um vasto campo à ser ainda explorado. A revisão da literatura mostra que as teorias evoluíram consideravelmente desde que a daementia praecox foi descrita. O estudo de Kraepelin teve como consequência associar a esquizofrenia à uma evolução adversa — e assim é o caso para a doença mental grave como um todo. Os estudos catamnésicos contradizem essa concepção, no entanto é principalmente graças aos pacientes e seus familiares, assim como às associações de pacientes e à relatos em primeira pessoa, que os campos da psiquiatria e da psicologia devem essas mudanças. Assim, diferentes paradigmas foram usados para modelar a remissão, a recuperação ou a reabilitação. Se as perspectivas de recuperação estão hoje bastante difundidas, os becos sem saída com que se depara, no que diz respeito à evolução dos campos médicos das doenças de longa duração, indicam o caminho para a investigação tendo em conta os factores subjectivos, e isso constitui um caminho para futuras pesquisas em psicanálise explorado descrita todo concepção familiares pessoa mudanças Assim remissão reabilitação difundidas depara duração subjectivos

Recuperarse de la esquizofrenia queda aún un vasto campo por explorar. La revisión de la literatura muestra que las teorías han evolucionado considerablemente desde que se describió la daementia praecox. La descripción de Kraepelin llevó a asociar la esquizofrenia con una evolución deficiente/deficitaria, y lo mismo ocurre con cualquier enfermedad mental grave. Los conocidos estudios catamnésicos van a contradecir esta concepción. Sin embargo, la transformación de la psiquiatría y la psicología se debe en gran parte a las asociaciones de pacientes, a los testimonios de familiares o relatos en primera persona. Si hoy las perspectivas de recuperación de la esquizofrenia se conocen bastante bien, los callejones sin salida a los que se enfrentan así como la evolución de los especialidades médicas dedicadas a las enfermedades de larga duración, apuntan en esta investigación la necesidad de integrar los factores subjetivos de la evolución, lo que constituye una vía / una pista/ que seguir para futuras investigaciones en psicoanálisis. explorar praecox deficientedeficitaria deficiente deficitaria deficiente/deficitaria grave concepción embargo pacientes persona bien duración pista psicoanálisis

Recovering from schizophrenia is a vast field yet to be explored. Review of literature shows that theories have considerably evolved since daementia praecox has been described. Kraepelin’s description has had the consequence of associating schizophrenia to an adverse evolution — and so it is for the severe mental illness as a whole. Catamnestic studies have contradicted this conception, but it is mainly due to the patients and families of patients associations and first person accounts that the fields of psychiatry and psychology will owe these changes. Then, different paradigms were used to model remitting, recovering or rehabilitation. If the outlooks of recovery are today quite well spread, the blind alleys that it encounters, as far as the evolution of medical fields are concerned by long-run illnesses, show the way to research towards taking account of subjective factors, and that constitutes one avenue for future research in psychoanalysis explored described Kraepelins Kraepelin s whole conception changes Then remitting rehabilitation spread encounters longrun long run illnesses factors

Malgré les résultats des premiers aliénistes démontrant les potentialités de guérison de la maladie mentale, la description de la démence précoce par Kraepelin aura pour conséquence d’associer la psychose à une évolution déficitaire. De grandes études catamnestiques viendront contredire cette conception, mais c’est surtout aux associations d’usagers, et aux témoignages à la première personne, que la psychiatrie devra sa mutation dans le domaine. Si les perspectives de rétablissement sont maintenant assez bien diffusées en ce qui concerne la schizophrénie, les impasses qu’elles rencontrent, de même que l’évolution des disciplines médicales s’occupant des maladies au long cours, orientent actuellement la recherche vers une prise en compte de facteurs subjectifs d’évolution, ce qui constitue une piste pour de futures recherches en psychanalyse. mentale dassocier d associer déficitaire conception cest c est dusagers, dusagers usagers, usagers d’usagers personne domaine schizophrénie quelles qu elles rencontrent lévolution l soccupant s occupant cours dévolution, dévolution évolution, d’évolution psychanalyse

Resumo Este artigo propõe o estudo de alguns elementos trazidos por pesquisadores atuantes nas universidades brasileiras para o desenvolvimento de um pensamento crítico contemporâneo sobre a poesia. Perspectivas como a endereçamento do poema, as suas múltiplas vozes e gestos (coralidade, teatralidade), a sua relação com a alteridade, da qual o “feminino” constitui uma das figuras-chave, serão aqui revisitadas de forma a explorar uma pensatividade paradoxal, presente nas práticas poéticas ou “pós-poéticas” da poesia brasileira que nos desafiam hoje e que fazem a poesia derivar para uma tensão produtiva com os seus outros: outras linguagens artísticas e outras instâncias de produção e recepção que serão convocadas no processo. O estudo aborda alguns textos críticos sobre a poesia publicados no Brasil entre os anos de 2015 e 2022, lidos a partir da diversidade de suas próprias referências teóricas, eventualmente acompanhadas por algumas propostas que unem um pensamento sobre a poesia a um pensamento sobre o pensamento, como as de Michel Deguy e de Jacques Derrida. poema coralidade, coralidade (coralidade teatralidade, teatralidade , teatralidade) alteridade feminino “feminino figuraschave, figuraschave figuras chave, chave figuras-chave paradoxal póspoéticas pós “pós-poéticas outros processo 201 2022 teóricas Derrida 20 202 2

Abstract This article proposes a study of some elements brought by active researchers from Brazilian universities for the development of contemporary critical thinking on poetry. Perspectives such as the address of the poem, its multiple voices and gestures (chorality, theatricality), its relationship to otherness, of which the “feminine” constitutes one of the key figures, will thus be revisited here in order to exploit a paradoxical pensiveness, present in poetic or “post-poetic” practices of Brazilian poetry which challenge us today and which cause poetry to drift towards a productive tension with its others: other artistic languages and other instances of production and reception which will be summoned in the process. The study involves some critical works on poetry published in Brazil between the years 2015 and 2022, read in the diversity of their own theoretical references, accompanied by some propositions which join a thought on poetry and a thought on thought itself, as those of Michel Deguy and Jacques Derrida. poem chorality, chorality (chorality theatricality, theatricality , theatricality) otherness feminine “feminine figures pensiveness postpoetic post “post-poetic others process 201 2022 references itself Derrida 20 202 2

Résumé Cet article propose l’étude de quelques éléments apportés par des chercheurs actifs dans des universités brésiliennes pour l’élaboration d’une pensée critique contemporaine sur la poésie. Des perspectives telles que l’adresse du poème, ses multiples voix et gestes (choralité, théâtralité), son rapport à l’altérité, dont le “féminin” constitue l’une des figures-clé, seront ainsi révisitées ici afin d’exploiter une pensivité paradoxale, présente dans des pratiques poétiques ou “post-poétiques” de la poésie brésilienne qui nous interpellent aujourd’hui et qui font dériver la poésie vers une tension productive avec ses autres: d’autres langages artistiques et d’autres instances de production et de réception qui seront convoqués dans le processus. L’étude concerne quelques textes critiques sur la poésie publiés au Brésil entre les années 2015 et 2022, lus dans la diversité de leurs propres références théoriques, éventuellement accompagnées par quelques propositions alliant une pensée de la poésie à une pensée de la pensée, comme celles de Michel Deguy et de Jacques Derrida. létude l étude lélaboration élaboration dune d ladresse adresse poème choralité, choralité (choralité théâtralité, théâtralité , théâtralité) laltérité, laltérité altérité, altérité l’altérité féminin “féminin lune figuresclé, figuresclé figures clé, clé figures-clé dexploiter exploiter paradoxale postpoétiques post “post-poétiques aujourdhui aujourd hui autres dautres processus Létude L 201 2022 théoriques Derrida 20 202 2

ABSTRACT Currently, the incidence of esophageal cancer continues to rise around the world. Because of its good early prognosis, it is of great significance to establish an effective model for predicting the survival of EC patients. The purpose of this study was to predict survival after diagnosis in Esophageal Cancer (EC) patients by constructing a valid clinical nomogram. In this study, 5037 EC patient samples diagnosed from 2010 to 2015 were screened by accessing the SEER database, and 8 independent prognostic factors were screened by various methods, and Cox multivariate regression was included to construct a prognostic model and nomogram for esophageal cancer. to estimate esophageal cancer recurrence and overall survival. Calibration of the nomogram predicted probabilities of 1-year, 3-year and 5-year survival probability, which were closely related to actual survival. In conclusion, this study validated that the column-line graphical model can be considered an individualized quantitative tool for predicting the prognosis of patients with EC in order to assist clinicians in making therapeutic decisions. Currently world (EC 503 201 database methods 1year, 1year year 1 year, 1-year 3year 3 5year 5 probability conclusion columnline column line decisions 50 20 2

Abstract Background Neonatal Intrahepatic Cholestasis (NICCD), as the early-age stage of Citrin deficiency involving liver dysfunction, lacks efficient diagnostic markers. Procalcitonin (PCT) has been identified as a biomarker for infection as well as various organ damage. This study aimed to explore the potential of PCT as a biomarker for NICCD. Methods In a single-center retrospective case-control study. Serum PCT concentrations before and after treatment of 120 NICCD patients, as the study group, were compared to the same number of cholestatic hepatitis patients, as the control group. The potential value of PCT to discriminate NICCD from control disease was further explored using Receiver Operating Characteristic (ROC) curve analysis and compared to those of other inflammatory markers. Results There was a significantly higher level of PCT in NICCD patients than in the control group. PCT concentrations were only weakly correlated with neutrophil counts and CRP levels (p ˂ 0.05). At a cut-off value of 0.495 ng/mL, PCT exhibited a significantly higher diagnostic value compared to other inflammatory markers for discriminating NICCD from the control, with a sensitivity of 90.8 % and specificity of 98.3 %. Conclusion PCT might be used as an initial biomarker to discriminate children with NICCD from another hepatitis disease. NICCD, , (NICCD) earlyage early age dysfunction (PCT damage singlecenter single center casecontrol case 12 group ROC (ROC p 0.05. 005 0.05 . 0 05 0.05) cutoff cut off 0495 495 0.49 ngmL ng mL ng/mL 908 90 8 90. 983 98 3 98. (NICCD 1 00 0.0 049 49 0.4 9 0. 04 4

Enhanced corrosion-resistant Ni-Cu-P amorphous coatings were applied to AZ91D magnesium alloy substrates using an integrated approach that included direct-current (DC) copper pre-plating and electroless Ni-Cu-P plating at varying CuSO4 concentrations. The effects of CuSO4 concentration on the microstructure, electrochemistry behavior and corrosion rate of Ni-Cu-P coatings and the adhesion between the Ni-Cu-P coating and the magnesium alloys substrate were investigated. The results indicated that the surface of the Ni-Cu-P ternary coating which integrated well with the magnesium alloys substrate exhibited heterogeneous cell structure with relatively flat and dense structure. When the CuSO4 concentration was 0.8 g/L, the mass fraction of P in the coating was 9.06 wt% meaning amorphous Ni-Cu-P coating. The results of the Nyquist and Bode graph, corrosion rate, corrosion morphologies and of the Ni-Cu-P coatings with different CuSO4 addition indicated that the corrosion resistance reached optimization with corrosion potential of -0.31 V, the corrosion current density of 0.0039 A/cm2 when the CuSO4 concentration is 0.8 g/L. Furthermore, the adhesion test confirmed that the adhesion of Ni-Cu-P coatings improved gradually as the CuSO4 concentration increased and exhibited optimum when added 1.0 g/L CuSO4. The obtained Ni-Cu-P coating with amorphous structure prevented effectively magnesium alloy from corrosion. corrosionresistant resistant NiCuP Ni Cu AZD AZ D directcurrent direct DC (DC preplating pre CuSO concentrations microstructure investigated 08 0 8 0. gL g L 906 9 06 9.0 wt graph 0.31 031 31 -0.3 V 00039 0039 0.003 Acm2 Acm A cm2 cm A/cm Furthermore 10 1 1. 90 9. 0.3 03 3 -0. 0003 003 0.00 -0 000 00 0.0 -

RESUMO Objetivos: A osteoartrite (OA) é uma doença degenerativa acompanhada de lesão dos condrócitos. Este estudo examinou a desregulação do microRNA-650 (miR-650) nos tecidos da cartilagem de doentes com OA. A sua função e mecanismo também foram explorados em modelos celulares de OA. Métodos: Os níveis de miR-650 foram examinados em 15 tecidos de cartilagem de OA e em 10 tecidos de cartilagem normal saudável. As células SW1353 foram utilizadas para experiências de função celular, e a IL-1β atua sobre as células para imitar as condições da OA in vitro. Foram detectadas funções celulares, incluindo a proliferação, a apoptose e a inflamação. O gene alvo a jusante do miR-650 foi reconhecido e confirmado por meio de análise bioinformática e ensaio de atividade da luciferase. Foram efetuadas experiências de recuperação para verificação do mecanismo. Resultados: Foi testada uma expressão oprimida do miR-650 tanto em doentes com OA como em modelos celulares. A sobreexpressão do miR-650 aumentou a proliferação celular, mas suprimiu a apoptose e a inflamação da SW1353. Como gene alvo do miR-650, a sobreexpressão do WNT1 contrariou o papel do miR-650 na função do SW1353. Conclusão: O miR-650 pode proteger contra a lesão da cartilagem articular na OA através da ação sobre o WNT1. Nível de Evidência I, Estudo de Experimental. Objetivos (OA condrócitos microRNA650 microRNA 650 microRNA-65 miR650 miR (miR-650 Métodos miR-65 1 saudável SW SW135 celular IL1β ILβ IL 1β β vitro luciferase Resultados miR650, 650, WNT Conclusão I Experimental microRNA65 65 microRNA-6 miR65 (miR-65 miR-6 SW13 microRNA6 6 microRNA- miR6 (miR-6 miR- SW1 (miR- (miR

ABSTRACT Objectives: Osteoarthritis (OA) is a degenerative disease associated with chondrocyte injury. This study investigated the dysregulation of microRNA-650 (miR-650) in cartilage tissues of patients with OA. Its function and mechanism were also investigated in OA cell models. Methods: miR-650 levels were examined in 15 OA cartilage tissues and ten healthy cartilage tissues. SW1353 cells were used for cell function experiments and IL-1β was applied to the cells to mimic OA conditions in vitro. Cell functions such as proliferation, apoptosis, and inflammation were detected. The downstream target gene of miR-650 was identified and confirmed by bioinformatic analysis and luciferase activity assay. Rescue experiments were performed to verify the mechanism. Results: Suppressed expression of miR-650 was tested in patients with OA and cell models. Overexpression of miR-650 increased cell proliferation but suppressed apoptosis and inflammation of SW1353. As the target gene of miR-650, WNT1 overexpression counteracted the role of miR-650 in the function of SW1353. Conclusion: miR-650 can protect against articular cartilage injury in OA by targeting WNT1. Level of Evidence I, Experimental Study. Objectives (OA microRNA650 microRNA 650 microRNA-65 miR650 miR (miR-650 models Methods miR-65 1 SW SW135 IL1β ILβ IL 1β β vitro detected assay Results miR650, 650, WNT Conclusion I Study microRNA65 65 microRNA-6 miR65 (miR-65 miR-6 SW13 microRNA6 6 microRNA- miR6 (miR-6 miR- SW1 (miR- (miR