Resumen La cuenca baja del río Acre se ubica en una zona de deforestación con la implementación de pastizales para ganado vacuno en suelos susceptibles a la erosión y clima ecuatorial. La existencia de mataderos y ganado vacuno en el municipio de Boca do Acre, en el estado de Amazonas, es uno de los problemas vinculados a la deforestación en la Amazonía brasileña. Ante este escenario, se presentó una estimación de las pérdidas de suelo con la aplicación de la Ecuación Universal en un sistema de información geográfica. En la metodología, se desarrolló una base de datos con información vectorizada para extraer las áreas de tipos de suelo y cobertura del suelo, incluyendo el análisis espacial de pendientes extraído del modelo digital de elevación. Como resultado del análisis de las áreas por geoprocesamiento y vectorización, se obtuvieron los cálculos de las parcelas de erosión a través de tablas con los parámetros adoptados por los referentes científicos. Se encontró que el 60% de la pérdida de suelo ocurre en el área agrícola en el 11% del territorio de la cuenca, siendo predominantemente en áreas de asentamientos rurales en el estado de Acre. Como resultado de la estimación, la pérdida de suelo en la cuenca baja del río Acre fue de 386.422 t/ha/año, con una producción de 46 millones de toneladas de sedimentos por año.

Abstract The Lower Acre River Basin is located in an area of deforestation with the implementation of pastures for beef cattle ranching in soils susceptible to erosion and equatorial climate. The existence of slaughterhouses and beef cattle in the municipality of Boca do Acre, in the state of Amazonas, is one of the problems linked to deforestation in the Brazilian Amazon. Given this scenario, an estimate of soil losses was presented with the application of the Universal Equation in a geographic information system. In the methodology, a database was elaborated with vectorized information for the extraction of the areas of the types of soils and land cover, including the spatial analysis of slopes extracted from the digital elevation model. Due to the analysis of the areas by geoprocessing occurring by vectorization, the calculations of the erosion plots were obtained through tables with the parameters adopted by the scientific references. It was found that 60% of the soil loss occurs in the area of agriculture in 11% of the territory of the watershed, being predominantly in areas of rural settlements of the state of Acre. As a result of the estimate, soil loss in the Lower Acre River Basin was 386,422 t/ha/year, with a production of 46 million tons of sediment per year.

Resumo A Bacia do Baixo Rio Acre está localizada em uma área de desflorestamento com implantação de pastagens para pecuária de corte em solos suscetíveis à erosão e clima equatorial. A existência de abatedouros e pecuária de corte implantada no município de Boca do Acre, no Amazonas, é um dos problemas vinculados ao desmatamento da Amazônia Brasileira. Diante desse cenário, foi apresentada uma estimativa de perdas de solo com aplicação da Equação Universal em sistema de informação geográfica. Na metodologia, foi elaborado um banco de dados com informações vetorizadas para extração das áreas dos tipos de solos e cobertura da terra, incluindo a análise espacial de declividades extraídas do modelo digital de elevação. Em decorrência da análise das áreas pelo geoprocessamento ocorrer pela vetorização, foram obtidos os cálculos das parcelas de erosão através de tabelas com os parâmetros adotados pelas referências científicas. Foi constatado que 60% da perda de solo ocorrem na área de agricultura em 11% do território da bacia hidrográfica, sendo predominantemente em áreas de assentamentos rurais do estado do Acre. Como resultado da estimativa, a perda de solos na Bacia do Baixo Rio Acre foi de 386.422 t/ha/ano, com uma produção de 46 milhões de toneladas de sedimentos por ano.

Resumen Introducción. La erosión acelerada del suelo es una de las principales causas de la degradación del suelo, que se ve reforzada por las actividades humanas que reducen la cobertura del suelo y aumentan su densidad. Metodologia: Por lo tanto, el objetivo de este estudio es cuantificar y comparar las pérdidas de suelo por erosión, entre áreas con agricultura convencional y vegetación natural en el sitio Potós ubicado en la zona rural del municipio de Ubajara, Ceará, Brasil. Resultados. Para monitorear la erosión, se instalan nueve pines de erosión en cada tratamiento, distribuidos en forma triangular, en el sentido de la pendiente, entre las hileras de plantas. El monitoreo se realizará mensualmente durante los años 2020 y 2021. Las pérdidas mensuales varían entre 0 y 948,73 Mg ha-1 mes, siendo las mayores en los meses más lluviosos, registrándose las mayores pérdidas en el año de mayor precipitación total acumulada.

Abstract Introduction. Accelerated soil erosion is one of the major causes of land degradation, which is exacerbated by human activities that reduce soil cover and increase its density. Objective. This study aimed to quantify and compare the levels of soil erosion between areas with conventional agriculture and natural vegetation at the Potós site located in the rural area of the municipality of Ubajara, Ceará, Brazil. Methodology. To monitor erosion, nine erosion pins were installed in each treatment area, arranged in a triangular mesh pattern, in the direction of the slope and between the rows of plants. Monitoring will occur monthly during 2020 and 2021. Results. Monthly losses range from 0 to 948.73 Mg ha-1 month, with the highest losses occurring in the driest months. The greatest losses were recorded in the year with the highest total accumulated precipitation.

Resumo Introdução: A erosão acelerada do solo é uma das principais causas de sua degradação, sendo esta potencializada por atividades antrópicas que reduzem a cobertura do solo e aumentam sua densidade. Objetivo: Ante isso, com o presente estudo objetivou-se quantificar e comparar as perdas de solos por erosão, entre áreas com agricultura convencional e vegetação natural no sítio Potós localizado na zona rural do município de Ubajara, Ceará, Brasil. Metodologia: Para monitorar a erosão foram instalados nove pinos de erosão em cada tratamento, distribuídos em malha triangular, no sentido do declive e entre as fileiras de plantas. O monitoramento ocorreu mensalmente durante os anos de 2020 e 2021. Resultados: As perdas de solos mensais variaram entre 0 e 948,73 Mg ha-1 por mês e foram maiores nos meses mais chuvosos, sendo as maiores perdas registradas no ano com maior precipitação total acumulada.

SIGNIFICANCE: Biodiversity offsetting is a last-resort scheme to prevent biodiversity loss due to development. However, measuring biodiversity is a complex endeavour, even more so in hyperdiverse landscapes. With few South African scientists able to comprehensively measure biodiversity, assuming equivalence between sacrificial and offset areas would be problematic and potentially fatal. Caution is required as the erosion of our unique biodiversity is at stake. We advise that a panel of biome-specific experts and data modellers unite to provide tools for more accurate trade-offs, based on functional diversity. In the meantime, the value of focusing on landscape heterogeneity is highlighted.

Abstract (Introduction): Coastal areas constitute the interface between land and marine environments, connected through multiple natural and socioecological processes that contribute to human well-being. (Objective): Identify land and marine uses and activities with mutual implications and biophysical processes in the northern region of the Bonaerense Coastal Ecosystem (Argentina), in order to evaluate the degree of compatibility or conflict between these activities, with emphasis on the fishing activity. (Methodology): The land-sea-land (T-M-T) methodological analysis was applied. Uses and activities (U&A) and biophysical processes of marine and land origin were determined. Interactions between marine-land and biophysical processes T-M-T were identified for further categorization and analysis. (Results): A total of 121 U&A sea-land-sea (L-S-L) interactions related to fishing were detected. Medium conflicts were mainly caused by competition for space or resources and were associated with the coexistence of U&A (tourism, fishing, and communication activities), both spatially and temporally. Of the total, 68 negative interactions were observed between biophysical processes and U&A L-S-L, which were linked to climatic events and the effects of climate change (variation in sea surface temperature, atmospheric and oceanic circulation, as well as variations in sediment transport and coastal erosion). (Conclusions): The analysis carried out constitutes an advancement in the study of U&A T-M-T in coastal-marine areas of the Atlantic coast and their interactions, with emphasis on fishing activities, as a contribution to their management with an ecosystemic approach.

Resumen (Introducción): Los espacios litorales constituyen la interfaz entre los ambientes terrestres y marinos, conectados por múltiples procesos naturales y socioecológicos, proporcionando bienes y servicios ecosistémicos para el bienestar humano. (Objetivo): Identificar los usos y actividades tanto terrestres como marinos con implicancias mutuas y los procesos biofísicos en la región norte del Ecosistema Costero Bonaerense (Argentina), con el fin de evaluar el grado de compatibilidad o conflicto entre estas actividades, con énfasis en el sector pesquero. (Metodología): Se aplicó el análisis metodológico tierra-mar-tierra (T-M-T). Se determinaron los usos y actividades (UyA), así como procesos biofísicos de origen marino y terrestre. Se identificaron las interacciones entre UyA marinos y terrestres, y procesos físicos T-M-T, para su posterior categorización y análisis de las interacciones previamente identificadas. (Resultados): Se notaron 121 interacciones de UyA T-M-T vinculadas con la pesca. Predominaron los conflictos medios por competencia de espacio o recursos y se relacionaron con la coexistencia espacial y temporal de UyA (turísticas, pesquera y comunicaciones). Se detectaron 68 interacciones negativas entre los procesos biofísicos y UyA asociados a eventos climáticos e impactos derivados del cambio climático (modificaciones en la temperatura superficial del mar, circulación atmosférica y oceánica, así como variaciones en el transporte de sedimentos y erosión costera). (Conclusiones): El análisis efectuado constituye un avance en el estudio entre UyA T-M-T en zonas litorales costero-marinas de la costa atlántica y de sus interacciones, con énfasis en la actividad pesquera, como aporte a la gestión de aquellos, con un enfoque ecosistémico.

Abstract (Introduction): Coastal areas constitute the interface between land and marine environments, connected through multiple natural and socioecological processes that contribute to human well-being. (Objective): Identify land and marine uses and activities with mutual implications and biophysical processes in the northern region of the Bonaerense Coastal Ecosystem (Argentina), in order to evaluate the degree of compatibility or conflict between these activities, with emphasis on the fishing activity. (Methodology): The land-sea-land (T-M-T) methodological analysis was applied. Uses and activities (U&A) and biophysical processes of marine and land origin were determined. Interactions between marine-land and biophysical processes T-M-T were identified for further categorization and analysis. (Results): A total of 121 U&A sea-land-sea (L-S-L) interactions related to fishing were detected. Medium conflicts were mainly caused by competition for space or resources and were associated with the coexistence of U&A (tourism, fishing, and communication activities), both spatially and temporally. Of the total, 68 negative interactions were observed between biophysical processes and U&A L-S-L, which were linked to climatic events and the effects of climate change (variation in sea surface temperature, atmospheric and oceanic circulation, as well as variations in sediment transport and coastal erosion). (Conclusions): The analysis carried out constitutes an advancement in the study of U&A T-M-T in coastal-marine areas of the Atlantic coast and their interactions, with emphasis on fishing activities, as a contribution to their management with an ecosystemic approach.

Resumen (Introducción): Los espacios litorales constituyen la interfaz entre los ambientes terrestres y marinos, conectados por múltiples procesos naturales y socioecológicos, proporcionando bienes y servicios ecosistémicos para el bienestar humano. (Objetivo): Identificar los usos y actividades tanto terrestres como marinos con implicancias mutuas y los procesos biofísicos en la región norte del Ecosistema Costero Bonaerense (Argentina), con el fin de evaluar el grado de compatibilidad o conflicto entre estas actividades, con énfasis en el sector pesquero. (Metodología): Se aplicó el análisis metodológico tierra-mar-tierra (T-M-T). Se determinaron los usos y actividades (UyA), así como procesos biofísicos de origen marino y terrestre. Se identificaron las interacciones entre UyA marinos y terrestres, y procesos físicos T-M-T, para su posterior categorización y análisis de las interacciones previamente identificadas. (Resultados): Se notaron 121 interacciones de UyA T-M-T vinculadas con la pesca. Predominaron los conflictos medios por competencia de espacio o recursos y se relacionaron con la coexistencia espacial y temporal de UyA (turísticas, pesquera y comunicaciones). Se detectaron 68 interacciones negativas entre los procesos biofísicos y UyA asociados a eventos climáticos e impactos derivados del cambio climático (modificaciones en la temperatura superficial del mar, circulación atmosférica y oceánica, así como variaciones en el transporte de sedimentos y erosión costera). (Conclusiones): El análisis efectuado constituye un avance en el estudio entre UyA T-M-T en zonas litorales costero-marinas de la costa atlántica y de sus interacciones, con énfasis en la actividad pesquera, como aporte a la gestión de aquellos, con un enfoque ecosistémico.

Résumé: Cet article étudie la polarisation socio-territoriale du vote à Mexico, dans une perspective comparative et historique. La polarisation politique touche un nombre croissant de démocraties. Cependant, malgré le caractère intuitif du concept, il n’existe pas de consensus sur sa définition, ni sur ses origines et ses conséquences. Le débat est marqué par le cas américain, caractérisé par une polarisation due au bipartisme et centrifuge vers deux extrêmes opposés, lesquels s’éloignent et se rapprochent de plus en plus. Au Mexique, en revanche, la polarisation s’opère dans un contexte d’érosion, de volatilité et de fragmentation partisane, avec une dynamique centripète qui oppose une coalition gouvernementale pragmatique et hybride à un front d’opposition encore plus hétérogène en termes idéologiques, géographiques et socioculturels. L’étude de ce cas crucial fournit des outils pour saisir et mesurer la polarisation socio-territoriale du vote dans la capitale, et pour la situer dans le contexte fédéral et international.

Resumen: Este artículo estudia la polarización socioterritorial del voto en la Ciudad de México, en perspectiva comparada e histórica. La polarización política afecta a un número creciente de democracias. Empero, pese al carácter intuitivo del concepto, no existe un consenso sobre su definición, ni sobre sus orígenes y consecuencias. El debate está marcado por el caso estadounidense, caracterizado por una polarización bipartidista y centrífuga hacia dos extremos opuestos que se distancian y se cohesionan de manera creciente. En México, en cambio, la polarización se produce en un contexto de erosión, volatilidad y fragmentación partidista, con una dinámica centrípeta que opone una coalición de gobierno pragmática e híbrida, a un frente opositor todavía más heterogéneo en términos ideológicos, geográficos y socioculturales. El estudio de este caso crucial proporciona herramientas para captar y medir la polarización socioterritorial del voto capitalino, y para situarla en el contexto federal e internacional.

Abstract: This article studies the socio-territorial polarization of the vote in Mexico City, in comparative and historical perspective. Political polarization affects a growing number of democracies. However, despite the intuitive nature of the concept, there is no consensus on its definition, nor on its origins and consequences. The debate is marked by the case of the United States, characterized by a bipartisan and centrifugal polarization towards two opposing extremes that are becoming both increasingly distant from each other as well as more cohesive. In Mexico, by contrast, polarization occurs in a context of party erosion, volatility and fragmentation, with a centripetal dynamic that sets a pragmatic and hybrid government coalition against an even more heterogeneous opposition front in ideological, geographic, and socio-cultural terms. The study of this key case provides tools to understand and measure the socio-territorial polarization of the vote in the capital, and to place it in the Mexican and international context.

ABSTRACT This article proposes to reflect on the relevance of the militarization process in educational centers in Honduras, in its relationship with the paradigm of peace education. Considering a documentary review and the analysis of data on the events following the 2009 coup d'état from a content analysis, militarization is approached as a more subtle phenomenon that is not only based on the imposition of force, but also occurs invisibly in society. This perspective raises significant concerns, such as the possible worsening of social inequalities and the erosion of fundamental rights. The connection between the military and education poses an ethical dilemma since it can put children's rights at risk and limit opportunities to develop spaces for democratic learning and harmonious coexistence. The vision of militarizing society continues to occupy and invade spaces in multiple Honduran social settings.

RESUMEN Este artículo propone reflexionar sobre la relevancia del proceso de militarización en los centros educativos de Honduras, en su relación con el paradigma de la educación para la paz. Considerando una revisión documentaria y el análisis de los datos sobre los acontecimientos posteriores al golpe de Estado de 2009 desde un análisis de contenido, se aborda la militarización como un fenómeno más sutil que no solo se basa en la imposición de la fuerza, sino que también se presenta de manera invisible en la sociedad. Esta perspectiva plantea preocupaciones significativas, como el posible recrudecimiento de las desigualdades sociales y la erosión de los derechos fundamentales. La conexión entre lo militar y lo educativo plantea un dilema ético, ya que puede poner en riesgo los derechos de la niñez y limitar las oportunidades de desarrollar espacios de aprendizaje democrático y de convivencia armoniosa. La visión de militarizar la sociedad continúa ocupando e invadiendo espacios en múltiples escenarios sociales hondureños.

In this paper we develop a physics-based model for lining erosion in steel ladles. The model predicts the temperature evolution in the liquid slag, steel, refractory bricks, and outer steel shell of the ladle. The flow of slag and steel is due to forced convection induced by inert gas injection, vacuum treatment (extreme bubble expansion), natural convection, and waves caused by the gas stirring. The lining erosion takes place by dissolution of refractory elements into the steel or slag. The mass and heat transfer coefficients inside the ladle during gas stirring are modelled based on wall functions which take the distribution of wall shear velocities as a critical input. The wall shear velocities are obtained from computational fluid dynamics (CFD) simulations for a sample of scenarios, spanning out the operational space, and a model is developed using curve fitting. The model is capable of reproducing both thermal and erosion evolution well. Deviations between model predictions and industrial data are discussed. The model is fast and has been tested successfully in a 'semi-online' application. The model source code is available to the public at [https://github.com/SINTEF/refractorywear].

A methodology for building pragmatic physics-based models is here adapted to predict the erosion of ladle linings in the steel industry, in order to support operators when deciding whether the lining can be used safely for another heat. A defective lining may allow 140 t of molten steel to spill, with disastrous consequences for workers and plant. The adopted work flow for the development, challenges faced, and some model results are presented. One key learning outcome is that model development should allow time for maturing the process understanding, as well as for many iterations by 'questions-responses and actions' at various stages in the model development. Good interaction between the development team and industry case owner is an important success factor. Combining or extending the model with the use of machine learning and cognition-related methods, such as knowledge graphs and self-adaptive algorithms, is discussed.

Abstract Objective: To evaluate the usefulness of an Index of Suspicion Scale (ISS) based on the endoscopic and imaging correlation of the findings commonly observed in patients with conclusive histopathological confirmation of sinonasal papilloma (SPs). Study Design: Retrospective and correlational study. Material and Methods: A cohort of 103 consecutive patients with confirmed histopathological diagnosis of SPs were analyzed during the period 2000-2019, in which the endoscopic and radiological features were evaluated through a bimodal CT/MRM protocol, with whose uncovering a correlative scale of findings was developed that can allow to deduce its diagnosis. Results: All patients with SPs had endonasal polypoidal masses, of which only 91% of the cases showed opacified tomographic images coinciding with the endoscopic finding. Focal hyperostosis was observed in 79% patients. Sinonasal bony wall erosion was observed in 84%. Contoured cerebriform pattern images were identified in 86% of T1-weighted and T2-weighted MRI studies. Correlation of endoscopic and imaging findings, based on sensitivity measures and positive predictive values, showed results of diagnostic probability and reliability with an overall average global mean of 90%. The SPs assessment criteria in the proposed SIS considered all above-mentioned findings. Through this correlative scale, 19% of patients were detected with early SPs (low suspicion), 31% were found to have moderately growing SPs (moderate suspicion) and 50% were identified with SPs of greater size (high suspicion). Conclusion: The proposed ISS was able to allow a satisfactory clinical diagnosis of SPs. The correlation of the clinical criteria considered proved that it can be a useful guide in the timely clinical assessment of these neoplasms.

Abstract Primary ciliary dyskinesia (PCD) is a rare genetic disease characterized by an abnormality in the function or structure of the cilia, coursing with pulmonary, otological and nasosinusal manifestations. Hypoacusis affects 60% of patients with PCD and results mainly from otitis media with effusion (OME) and otological complications such as simple or cholesteatomatous chronic otitis media (COM). Clinical case: Female patient, 52 years old, with PCD, followed in the Otorhinolaryngology department for bilateral COM and chronic rhinosinusitis. Her surgical history includes nasosinusal endoscopic surgery and repeated myringotomies with placement of transtympanic ventilation tubes (TVTT), bilaterally. Despite the placement of TVTT, the simple tone audiogram revealed bilateral severe chronic mixed deafness, with mean bone thresholds of 36.25 dB on the right and 30 dB on the left. Ear tomography excluded erosion or discontinuity of ossicular chains, presence of cholesteatoma and pathology of the inner ear. The patient underwent surgery to place a bone conduction implant in her right ear. After 4 weeks, the processor was activated. The free field audiogram revealed a mean threshold of 26.25dB. Conclusion: In PCD patients, insertion of TVTT is still a controversial treatment for OME. Persistent postoperative otorrhea is a frequent side effect and may complicate the use and tolerance of hearing aids. Bone conduction implants should be considered in auditory rehabilitation, with excellent results.

Resumo A discinésia ciliar primária (DCP) é uma doença genética rara caracterizada por uma anormalidade da função ou da estrutura dos cílios, cursando com manifestações pulmonares, otológicas e nasossinusais. A hipoacusia afeta 60% dos pacientes com DCP e resulta sobretudo de otite média com efusão (OME) e de complicações otológicas, como otite média crónica (OMC) simples ou colesteatomatosa. Caso clínico: Doente do sexo feminino, 52 anos, portadora de DCP, seguida na consulta de Otorrinolaringologia por OMC bilateral e rinossinusite crónica. Tem como antecedentes cirúrgicos, cirurgia endoscópica nasossinusal e repetidas miringotomias com colocação de tubos de ventilação transtimpânicos (TVTT), bilateralmente. Apesar da colocação de TVTT, o audiograma tonal simples revelava uma surdez mista severa crónica bilateralmente, com limiares ósseos médios de 36,25 dB à direita e de 30 dB à esquerda. A tomografia computorizada dos ouvidos excluiu erosão ou descontinuidade das cadeias ossiculares, presença de colesteatoma e patologia do ouvido interno. A doente foi submetida a cirurgia para colocação de implante de condução óssea no ouvido direito. Após 4 semanas da cirurgia, foi feita a ativação do processador. O audiograma tonal simples, em campo livre, revelou um limiar aéreo médio de 26,25dB. Conclusão: Nos doentes com DCP, a inserção de TVTT é ainda um tratamento controverso da OME. A otorreia pós-operatória persistente é um efeito colateral frequente, podendo complicar o uso e tolerância dos aparelhos auditivos. Por este motivo deverão ser considerados os implantes de condução óssea na reabilitação auditiva, apresentando excelentes resultados.

ABSTRACT Objective : To evaluate the remineralizing effect of synthetic saliva on eroded bovine dental enamel. Materials and methods : 50 enamel blocks were prepared from bovine teeth. The specimens were divided into 5 study groups according to treatment: group A (Colgate Total®, toothpaste containing fluoride), group B (MI Paste Plus®, toothpaste containing casein phosphopeptide, amorphous calcium phosphate [CPP-ACP] with fluoride), group C (Salival® Solution, synthetic saliva), group D (distilled water) and group E (no treatment). All specimens in groups A, B, C and D received 0.5% citric acid attacks for 2 minutes at 0, 8, 24 and 32 hours. After each acid attack, toothpastes corresponding to each treatment group were applied. The degree of mineralization was then evaluated by Raman microscopy and surface microhardness by Vickers microhardness. Results : Regarding the degree of mineralization and surface hardness, no significant differences (p > 0.05) were found in the eroded bovine tooth enamel treated with Colgate Total®, Mi Paste Plus® and Salival® Solution in comparison with the healthy enamel samples. But all presented a significantly higher degree of mineralization and surface hardness than the eroded bovine tooth enamel samples preserved in distilled water (p < 0.05). Conclusion : This in vitro study shows that the synthetic saliva Salival® Solution has a remineralizing potential on eroded bovine enamel.

RESUMEN Objetivo : Evaluar el efecto remineralizante de una saliva sintética en el esmalte dental bovino erosionado. Materiales y métodos : Se prepararon 50 bloques de esmalte de dientes de bovino. Las muestras fueron divididas en 5 grupos de estudio según el tratamiento: grupo A (Colgate Total®, pasta de dientes que contiene fluoruro), grupo B (MI Paste Plus®, pasta de dientes que contiene fosfopéptido de caseína-fosfato de calcio amorfo [CPP-ACP] con fluoruro), grupo C (Salival® Solución, saliva sintética), grupo D (agua destilada) y grupo E (sin tratamiento). Todos los especímenes de los grupos A, B, C y D recibieron ataques con ácido cítrico al 0,5 % durante 2 minutos a las 0, 8, 24 y 32 horas. Después de cada ataque ácido, se aplicaron las pastas de dientes correspondientes a cada grupo de tratamiento. Luego se procedió a evaluar el grado de mineralización mediante microscopía Raman y la microdureza superficial mediante microdureza Vickers. Resultados : Respecto al grado de mineralización y la dureza superficial, no se encontraron diferencias significativas (p > 0,05) en el esmalte dental bovino erosionado tratado con Colgate Total®, MI Paste Plus® y Salival® Solución en comparación con las muestras de esmalte sano; sin embargo, todas presentaron un grado de mineralización y dureza superficial significativamente mayor que las muestras de esmalte de dientes bovinos erosionados conservados en agua destilada (p < 0,05). Conclusión : Este estudio in vitro muestra que la saliva sintética Salival® Solución tiene un potencial remineralizante en el esmalte bovino erosionado.

RESUMO Objetivo : Avaliar o efeito remineralizante de uma saliva sintética no esmalte dentário bovino erodido. Materiais e métodos : Foram preparados 50 blocos de esmalte de dentes de bovinos. As amostras foram divididas em 5 grupos de estudo de acordo com o tratamento: grupo A (Colgate Total®, pasta dentífrica contendo flúor), grupo B (MI Paste Plus®, pasta dentífrica contendo fosfopeptídeo de caseína, fosfato de cálcio amorfo [CPP-ACP] com flúor), grupo C (Salival® Solution, saliva sintética), grupo D (água destilada) e grupo E (sem tratamento). Todos os espécimes dos grupos A, B, C e D receberam um ataque ácido cítrico a 0,5% durante 2 minutos às 0, 8, 24 e 32 horas. Após cada ataque ácido, foram aplicadas as pastas dentífricas correspondentes a cada grupo de tratamento. O grau de mineralização foi então avaliado por microscopia Raman e a microdureza superficial por microdureza Vickers. Resultados : Relativamente ao grau de mineralização e à dureza da superfície, não foram encontradas diferenças significativas (p > 0,05) no esmalte dentário bovino erodido tratado com Colgate Total®, Mi Paste Plus® e Salival® Solution em comparação com as amostras de esmalte saudável. Mas todos mostraram um grau significativamente mais elevado de mineralização e dureza superficial do que as amostras de esmalte de dentes de bovinos erodidos preservados em água destilada (p < 0,05). Conclusão : Este estudo in vitro mostra que a saliva sintética Salival® Solution tem um potencial remineralizante no esmalte bovino erodido.

Resumo Este trabalho analisa as ações e parcerias estabelecidas entre os integrantes das Secretarias Estaduais de Saúde e da Assistência Social do Rio de Janeiro e outras organizações da área da saúde e assistência para atender à emergência sanitária desencadeada pela síndrome congênita do vírus Zika entre os anos de 2015 e 2018. O contexto caracterizava-se por acentuada crise econômica, erosão da capacidade de governança das autoridades políticas no estado, e reduzido conhecimento técnico-científico sobre a epidemia. Além de análise de documentos relativos ao tema, foram feitas 17 entrevistas com gestores e profissionais das duas secretarias. Roteiros semiestruturados focalizaram ações intersetoriais e processos de cooperação e coordenação inter e intraorganizacional. A grade analítica contemplou aspectos dos papéis interpessoais, informacionais e de tomada de decisão dos gestores e técnicos. Os resultados mostram que, apesar da crise política e econômica, os atores das secretarias conseguiram criar um fluxo de atenção aos pacientes. Observou-se que mecanismos informais de cooperação e coordenação foram fundamentais para a criação de estratégias intersetoriais de longo prazo.

Abstract This paper focuses on the actions and partnerships established between members of the State Secretariats of Health and Social Assistance in Rio de Janeiro and other organizations in the health and assistance areas to respond to the health emergency triggered by the congenital Zika virus syndrome between 2015 and 2018. Some characteristics of the context were: a severe economic crisis, the erosion of the governance capacities of the state political authorities as well and scarce technical-scientific knowledge about the epidemic. The study was grounded on an analysis of documents related to the topic, 17 semi-structured interviews with managers and professionals from the two secretariats. Interview scripts focused on intersectoral actions and processes of cooperation and coordination within and between organizations. The analytical grid included aspects of the interpersonal, informational, and decision-making roles of managers and technicians. The results show that, despite the political and economic crisis, the Secretariat actors managed to create a flow of care for patients. Informal cooperation and coordination mechanisms were crucial for the creation of long-term intersectoral strategies.

ABSTRACT: Canine leishmaniasis (CanL) is a multifaceted disease triggered by the protozoan Leishmania infantum, characterized by diverse clinical presentations, including osteoarticular complications. Immune-mediated joint diseases invariably initiate at the synovial membrane, implicating its pivotal role in arthritis pathogenesis. This study aimed to investigate the influence of natural L. infantum infection on synovial fluid characteristics and the expression of immune markers, including TLR-2, FOXP3, and COX-2, in the synovial membrane. Twenty naturally infected dogs (NID) with L. infantum were sourced from the Zoonosis Surveillance Unit (ZSU). Clinical-orthopedic assessments were conducted, encompassing lameness, joint edema, crepitus, patellar luxation, and the drawer test. Synovial fluid (SF) parameters, including volume, appearance, viscosity, total nucleated cell count (TNC), neutrophil count, and total protein (TP) content, were determined. After anesthesia and euthanasia, synovial membrane specimens were obtained. SF protein concentrations categorized dogs into three groups: GI (2 to 2.5g/dL), GII (2.5 to 6.0g/dL), and GIII (>6g/dL). Inflammatory infiltrates and synovial membrane changes were assessed, and immunohistochemistry evaluated TLR-2, FOXP3, and COX-2 marker expressions. Clinical evaluations revealed various osteoarticular abnormalities in NID dogs, including lameness (55%), joint edema (25%), crepitus (30%), patellar luxation (20%), and positive drawer test (25%). Post mortem examinations revealed bilateral subchondral bone, meniscus, and trochlea erosion in 30% of cases. Amastigotes of L. infantum were identified extracellularly and within macrophages (60%). An inflammatory infiltrate was predominant in 70% of dogs, with varying intensity among the groups. Mononuclear cells, chiefly macrophages and lymphocytes, and neutrophils comprised the infiltrate. TLR-2 and COX-2 expression levels were elevated in GIII compared to GII and GI. Conversely, FOXP3 showed moderate expression in GI and minimal expression in GII and GIII. This study underscores the contributory role of L. infantum infection in the development of joint lesions in CanL. Additionally, alterations in the expression of immune markers TLR2, FOXP3, and COX2 within the synovial membrane imply the perpetuation and exacerbation of the inflammatory processes, shedding light on the intricate pathogenesis of CanL-induced arthritis. ABSTRACT CanL (CanL presentations complications Immunemediated Immune mediated L TLR2 TLR 2, 2 FOXP COX2, COX (NID ZSU. ZSU . (ZSU) Clinicalorthopedic orthopedic conducted (SF parameters volume appearance viscosity TNC, TNC , (TNC) TP (TP content determined euthanasia obtained groups ( 2.5g/dL, 25gdL gdL 2.5g/dL 5g dL g 2.5g/dL) 2.5 25 5 (2. 6.0g/dL, 60gdL 6.0g/dL 6 0g 6.0g/dL) >6g/dL. 6gdL >6g/dL 6g (>6g/dL) assessed COX- expressions 55%, 55 55% (55%) 25%, 25% (25%) 30%, 30 (30%) 20%, 20 20% (20%) 25%. bone meniscus cases 60%. 60 60% (60%) 70 cells lymphocytes TLR- Conversely Additionally processes CanLinduced induced (ZSU (TNC 2. (>6g/dL (55% (25% 3 (30% (20% (60% 7 (55 (25 (30 (20 (60 (5 (3 (6

RESUMO: A leishmaniose canina (LC) é uma doença causada pelo protozoário Leishmania infantum com diversas manifestações clínicas, incluindo alterações osteoarticulares. A membrana sinovial é o local inicial de eventos patogênicos em todos os tipos de doenças articulares mediadas pelo sistema imunológico. Devido a essa relação, o objetivo foi avaliar a influência da infecção natural por L. infantum nas características do líquido sinovial e na expressão de TLR-2, FOXP3 e COX-2 na membrana sinovial. Cães naturalmente infectados por L. infantum (NID, N=20) foram obtidos na Unidade de Vigilância de Zoonoses (UVZ). Critérios clínicos ortopédicos foram avaliados, assim como foram obtidas amostras de líquido sinovial por artrocentese. O volume, aspecto, viscosidade, contagem total de células nucleadas (TNC) e contagem de neutrófilos e proteína total (PT) no líquido sinovial (LS) foram determinados. Os cães foram anestesiados e posteriormente eutanasiados para obtenção da membrana sinovial. Os animais do estudo apresentaram claudicação (55%), edema (25%), crepitação na articulação do joelho (30%) e luxação patelar medial (20%) e foram positivos no teste da gaveta (25%). Trinta por cento (30%) dos cães apresentaram erosão bilateral do osso subcondral, menisco e tróclea. Amastigotas de L. infantum foram visualizadas extracelularmente e dentro de macrófagos (60% dos animais). Os cães foram ainda divididos em três grupos de acordo com a concentração de proteína no líquido sinovial: GI: 2 a 2,5g/dL (valor de referência normal), GII: 2,5 a 6,0g/dL, GIII: >6g/dL. Infiltrado celular inflamatório, bem como aumento da camada da membrana sinovial, foram identificados em 70% (14/20) dos cães. O infiltrado inflamatório estava ausente em membranas sinoviais originadas de GI, presente em GII com intensidade moderada e presente em GIII com intensidade alta. O infiltrado inflamatório era predominantemente composto por macrófagos, linfócitos e neutrófilos. Houve um aumento na expressão dos marcadores TLR2 e COX2 em GIII em comparação com os grupos GII e GI. Contudo, em relação à expressão de FOXP3, houve uma marcação moderada em GI e apenas uma marcação leve em GII e GIII. Este trabalho reforça o papel da infecção por L. infantum no desenvolvimento de lesões articulares em cães. Além disso, nosso estudo indica que a LC modifica a expressão de TLR2, FOXP3 e COX2 na membrana sinovial, o que implica a manutenção e progressão do processo inflamatório. RESUMO (LC clínicas osteoarticulares imunológico L TLR 2, TLR-2 FOXP COX COX- NID, NID (NID N=20 N20 N 20 UVZ. UVZ . (UVZ) avaliados artrocentese volume aspecto viscosidade TNC (TNC PT (PT LS (LS determinados 55%, 55 55% , (55%) 25%, 25 25% (25%) 30% 30 (30% 20% (20% 25%. subcondral tróclea 60% 60 (60 animais. animais) 25gdL gdL 5g dL g valor normal, normal normal) 5 60gdL 6 0g 6,0g/dL 6gdL 6g >6g/dL 70 14/20 1420 14 (14/20 alta Contudo disso TLR- N=2 N2 (UVZ (55% (25% 3 (30 (20 (6 7 14/2 142 1 (14/2 N= (55 (25 (3 (2 ( 14/ (14/ (5 (14 (1

ABSTRACT This study aimed to model nutrient losses in an Oxisol under varied soil properties and vegetation cover. The experimental area was located at the Paraná Rural Development Institute, in Santa Tereza do Oeste, Paraná, Brazil. The treatments consisted of six cover crops in summer, six cover crops in winter, and management systems no-tillage (NT) traditional (control), NT with gypsum, and NT with scarification. Nutrient data were collected at each natural rainfall through sample collection from collection troughs. The design was completely randomized, and the data were adjusted using an exponential function of two variables, as a function of soil density, macroporosity, straw dry mass, green cover, and rainfall. Greater losses of Mg and Ca was related to higher soil density and lower macroporosity. Lower losses of Mg, Ca, K, and P were associated with lower straw dry mass and higher green cover. K and P losses were stable for all soil density values, but they decreased with an increase in macroporosity. Institute Oeste Brazil summer winter notillage no tillage (NT control, control , (control) gypsum scarification troughs randomized variables macroporosity values (control