Abstract Within the paradigm of Spanish polar interrogative constructions, the interrogatives marked with qué used in Mexican Spanish (¿Qué Julia llamó?, ¿qué Julia no llamó?, ¿qué no Julia llamó?) have not been studied so far. This article analyzes the non-propositional meaning of these constructions based on the theoretical proposal by Sudo (2013). The paper argues that the two proposed biases, epistemic bias, and evidential bias, are necessary for analyzing these polar interrogatives. However, they are insufficient to capture the differences between the two negative polar interrogatives. The paper proposes that these interrogative constructions differ in their epistemic bias degree: with both requiring positive belief, but with different degrees of certainty.

Resumen Dentro del paradigma de construcciones interrogativas polares del español, las interrogativas marcadas con qué empleadas en el español de México (¿Qué Julia llamó?, ¿qué Julia no llamó?, ¿qué no Julia llamó?) no han sido estudiadas hasta ahora. Este artículo analiza el significado no proposicional de estas construcciones a partir de la propuesta teórica de Sudo (2013). Se muestra que los dos sesgos propuestos, sesgo epistémico y sesgo evidencial, son necesarios para el análisis de estas interrogativas polares, pero no son suficientes para capturar las diferencias entre las dos interrogativas polares negativas. El artículo propone que estas construcciones difieren en el grado de su sesgo epistémico: ambas requieren una creencia positiva, pero con diferente grado de certeza.

Resumen En el contexto de la economía política internacional, el régimen de protección de derechos humanos y el régimen de inversores extranjeros atraviesan tensiones como resultado de una arquitectura jurídica que privilegia la libertad de capitales. Un análisis de contenido del Acuerdo de Escazú revelaría, respecto al acceso a la justicia en temas ambientales, que las personas y la sociedad civil acceden a instancias judiciales y administrativas contempladas en la legislación nacional de cada país, mientras que los inversores extranjeros, bajo la figura de los tratados bilaterales de inversión (TBI) y libre comercio (TLC), recurren a la justicia mediante tribunales de arbitraje internacional que no siempre son independientes, imparciales y que privilegian los intereses del mercado. Esta arquitectura jurídica condiciona el accionar de los Estados frente a la sociedad civil y sus derechos. El Acuerdo de Escazú atraviesa desafíos jurídicos frente al régimen de protección a los inversores, en el cual las garantías económicas limitan las acciones concretas para abordar la crisis climática, proteger el medioambiente o hacer efectivos los derechos humanos.

Abstract In the context of the international political economy, the human rights protection regime and the foreign investor regime are in tension because of a legal architecture that privileges freedom of capital. A content analysis of the Escazú Agreement would reveal, with respect to access to justice in environmental matters, that individuals and civil society have access to judicial and administrative instances contemplated in national legislation, while foreign investors under bilateral investment treaties (BITs) and free trade agreements (FTAs) have access to justice through international arbitration tribunals that are not always independent, impartial and that privilege the interests of the market. This legal architecture conditions the actions of States in relation to society and its rights. The conclusions point out that the Escazú Agreement faces legal challenges in terms of the investor protection regime, where economic guarantees limit concrete actions to address the climate crisis, protect the environment or enforce human rights.

RESUMEN La Sentencia 1364-17-EP/23 de la Corte Constitucional aparentemente cerró la discusión sobre el alcance del art. 233 de la CRE en lo que respecta al peculado. Se afirma serían autores tanto servidores públicos como sujetos que no ostenten esta condición, independientemente de sus conductas. La resolución es insatisfactoria. En la misma no se confrontó si el contenido del precepto constitucional era suficiente para cumplir con la determinación que requiere la tipificación de una conducta. El debate no puede cerrarse sin alcanzar estos niveles de análisis. El objetivo de este artículo es desafiar esta decisión, presentando argumentos que no fueron considerados, y a través de estos, cuestionar las conclusiones alcanzadas. Desde la explicación de lo que es un intraneus y un extraneus, se plantea otras formas de interpretar el art. 233. Entre las alternativas, se selecciona la que se cree que guarda armonía con todo el sistema de normas. El art. 233 fija la necesidad de que en el peculado se sancione como autores a no servidores públicos y a privados, pero no es suficiente para ser aplicado directamente. Es el principio de legalidad el que cumple con el mandato de determinación. Finalmente, se resalta que la norma penal sí contempla supuestos donde pueden intervenir como autores personas sin la calidad de servidores públicos, casos en los que existe certeza sobre la conducta prohibida.

ABSTRACT Sentence 1364-17-EP/23 of Constitutional Court and article 233 of the CRE regarding embezzlement seems to be closed. It is stated that both public servants and the ones who do not hold this condition can be authors regardless of their conduct. The resolution is not acceptable as it did not confront whether the content of the constitutional precept was sufficient to comply with the determination required to classify a conduct. The debate cannot be closed without reaching these levels of analysis. The aim of this article is to challenge this decision with arguments that were not considered and can be used to question the conclusions reached. From the explanation of what an intraneus and an extraneus are, other ways of interpreting article 233 are proposed. Among the alternatives, the selected is the one that is believed to be in harmony with the entire system of regulations. Article 233 establishes the need to sanction to non-public and private servants as perpetrators of embezzlement. However, it is not enough to be applied directly. It is the principle of legality that fulfills the mandate of determination. Finally, it is highlighted that the criminal law does contemplate cases where people without the status of public servants may intervene as perpetrators, cases in which there is certainty about the prohibited conduct.

Introdução: As doenças cardiovasculares (DCV) continuam a ser a principal causa de mortalidade em todo o mundo. A adesão ao tratamento medicamentoso é uma questão importante no manejo das DCV crônicas, influenciando diretamente os resultados e os custos com saúde. Objetivos: Esta revisão sistemática, apoiada pela Sociedade Brasileira de Cardiologia, avalia o impacto da baixa adesão aos medicamentos cardiovasculares em desfechos clínicos críticos, como morte e eventos cardiovasculares. Métodos: Foi realizada uma busca abrangente em quatro bases de dados, incluindo Medline, Embase, Lilacs e Cochrane Library. A revisão incluiu revisões sistemáticas com meta-análises que relataram estimativas de risco para a adesão aos medicamentos cardiovasculares. Foram selecionadas quatro revisões sistemáticas, cada uma incorporando estudos observacionais. Resultados: Os principais achados indicam que um aumento na adesão aos medicamentos reduz significativamente o risco de eventos cardiovasculares, acidente vascular cerebral (AVC) e morte por todas as causas. Especificamente, uma melhoria de 20% na adesão a medicamentos antihipertensivos, hipolipemiantes e outros medicamentos cardiovasculares correlacionou-se com reduções nos eventos cardiovasculares de 7%, 10% e 9%, respectivamente; AVC de 17%, 13% e 18%; e morte de 12%, 9% e 10%. A certeza das evidências foi moderada, sugerindo que esses efeitos provavelmente estão presentes. Esses achados enfatizam a importância de melhorar a adesão ao tratamento medicamentoso para aprimorar os resultados clínicos no manejo das DCV. Conclusões: As evidências demonstraram reduções em desfechos duros tanto na prevenção primária quanto secundária através do controle de condições como hipertensão e concentrações elevadas de colesterol LDL, bem como os benefícios da terapia antiplaquetária em doenças ateroscleróticas. No entanto, são necessários estudos adicionais para elucidar melhor a relação entre a adesão aos medicamentos cardiovasculares e a melhoria dos desfechos clínicos críticos.

Background: Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. Medication adherence is an important issue in managing chronic CVD, directly influencing outcomes and healthcare costs. Objectives: This systematic review, supported by the Brazilian Society of Cardiology, evaluates the impact of poor adherence to cardiovascular medications on critical clinical outcomes such as death and cardiovascular events. Methods: A comprehensive search was conducted across four databases, including Medline, Embase, Lilacs, and the Cochrane Library. The review included systematic reviews with meta-analyses that reported risk estimates for adherence to cardiovascular medications. Four systematic reviews, each incorporating observational studies, were selected. Results: The principal findings indicate that an increase in adherence to medications significantly reduces the risk of cardiovascular events, stroke, and all-cause death. Specifically, a 20% improvement in adherence to antihypertensive, lipid-lowering, and other cardiovascular medications correlated with reductions in cardiovascular events by 7%, 10%, and 9%, respectively; stroke by 17%, 13%, and 18%; and death by 12%, 9%, and 10%. The certainty of the evidence was moderate, suggesting that these effects are likely present. These findings emphasize the importance of enhancing medication adherence to improve clinical outcomes in CVD management. Conclusions: Evidence has demonstrated reductions in hard endpoints in both primary and secondary prevention through the control of conditions such as hypertension and elevated LDL cholesterol concentrations, as well as the benefits of antiplatelet therapy in atherosclerotic disease. However, additional studies are needed to better elucidate the relationship between adherence to cardiovascular medications and the improvement of critical clinical outcomes.

Abstract Infection by the human immunodeficiency virus (HIV) poses a significant challenge to global health, profoundly impacting the quality of life of millions of people. Among the associated complications, periodontal diseases stand out due to their high prevalence and impact on the oral and systemic health of people living with HIV (PLWH). This systematic review aims to analyze the impact of non-surgical periodontal treatment in PLWH on quality of life, immunological status, and oral health outcomes. An exhaustive search will be conducted in multiple databases, complemented by a manual review of references. Comparative primary studies evaluating the effect of non-surgical periodontal therapy in PLWH will be included. Data synthesis will be performed through a narrative synthesis and descriptive tables to address the expected heterogeneity in the results. The certainty of the evidence will be assessed using the GRADE approach. This review will provide crucial information to guide clinical and policy decisions and identify areas for future research in this field.

Resumen La infección por el virus de la inmunodeficiencia humana (VIH) constituye un desafío significativo para la salud global, con un impacto profundo en la calidad de vida de millones de personas. Entre las complicaciones asociadas, las enfermedades periodontales destacan por su alta prevalencia y su impacto en la salud bucal y sistémica de las personas viviendo con VIH (PVVIH). Esta revisión sistemática tiene como objetivo analizar el impacto del tratamiento periodontal no quirúrgico en PVVIH en desenlaces relacionados con la calidad de vida, estado inmunológico y salud oral. Se realizará una búsqueda exhaustiva en múltiples bases de datos, complementada con una revisión manual de referencias. Se incluirán estudios primarios comparativos que evalúen el efecto de la terapia periodontal no quirúrgica en PVVIH. La síntesis de datos se realizará mediante una síntesis narrativa junto con tablas descriptivas para abordar la heterogeneidad esperada en los resultados. La evaluación de la certeza de la evidencia se realizará utilizando el enfoque GRADE. Esta revisión proporcionará información crucial para orientar decisiones clínicas y de políticas, así como identificar áreas para futuras investigaciones en este campo.

In hierdie bydrae sal aangetoon word op welke wyse Hegel in die Phänomenologie des Geistes (1988; hierma FvdG (2013)) betoog dat subjek en objek nie afsonderlik van mekaar bedink kan word nie. Die antwoord op hierdie vraagstuk lê in 'n bepaalde toeëiening van die begrip van die absolute wat as dialektiese bemiddeling tussen subjek en objek dien, waaruit die begrip van selfbewussyn na vore tree. Selfbewussyn is nie alleen 'n hoër vorm van subjektiwiteit nie, maar vorm deel van die groter werklikheid van subjek en objek. Enersyds is die belangrikheid van hierdie vraagstuk van so 'n aard dat dit verdien om geïsoleerd binne Hegel se Phänomenologie bespreek te word, en andersyds moet die vraagstuk gekontekstualiseer word sodat die wyer debatte waarbinne Hegel se antwoord op hierdie aangeleentheid neerslag vind, ook die nodige aandag kry. Ten slotte moet daar ook gewys word op die posisie wat hierdie onderwerp binne Hegel se eie sisteem beklee, naamlik as oorgang tot die begrip van Anerkennung, bloot om die problematiek van denke oor die selfbewussyn as geïsoleerde onderwerp uit te wys. Die debat rondom die verhouding tussen subjek en objek sal vanaf Kant gerekonstrueer word, met die twee sleutelfigure van Fichte en Schelling as verteenwoordigers van uiteenlopende strominge waaruit Hegel geput het. Beide staan egter 'n bemiddelende, spekulatiewe toevoeging tot die subjek-objek-verhouding, die absolute, voor. By Fichte staan die absolute nader aan die subjek en by Schelling die objek, oftewel die natuur. Hegel neem elemente by beide oor maar behou die absolute as bemiddeling. In die eerste drie hoofstukke van Hegel se Fenomenologie van die Gees (FvdG) word die objektiewe aanspraak wat die wetenskap op die waarheid maak ondersoek en word dit as ontoereikend aangebied aan die hand van die inherent weersprekende begrippe (dat 'n ding tegelyk uit 'n eenheid en veelheid van kragte kan bestaan) waarvan dit noodwendig gebruik maak om wetenskap te kan wees. Hiermee wil Hegel nie die wetenskaplike metode as sodanig irrelevant verklaar nie, maar poog om die groter beweging wat die begrip van objektiewe eksterne werklikheid moontlik maak, te identifiseer en uiteindelik te inkorporeer by 'n meer omvangryke begrip van waarheid. Sodanige omvangryke begrip sal noodwendig rekening moet hou met die subjektiewe; die verstandsaktiwiteit waaruit begrippe gevorm word. Anders as by sy voorgangers (Descartes en Kant) beweer Hegel egter nie dat die subjektiwiteit die werklikheid omvat nie, vandaar sy gebruik van die begrip van die fenomenologie, wat op die gebeurtenis van die verskynsels fokus. Die ware is nie 'n afgesonderde noumenale sfeer wat nooit deur die subjek geken kan word nie, maar ontvou as dít wat ten dele deur die subjektiewe, die interpreterende selfbewus-syn, oopgemaak word. Ten slotte dra die besef van die wederkerigheid van subjek en objek by tot die totstandkoming van die selfbewussyn, 'n begrip wat wys op die verweefdheid van bestaan (syn) en self. Drie fases van die objektiewe opvatting van die werklikheid word in die proses van die totstandkoming van selfbewussyn uitgedaag: die aansprake van die sintuiglike sekerheid, die waarneming (gegrond op Hume se sogenaamde "secondary impressions") en ten laaste die begrip van krag as dit wat onderliggend aan alle liggame is. Hegel wys daarop dat die selfbewussyn nie die resultaat, of passiewe waarnemer is van die werklikheid soos dit in die wetenskap voorgestel word nie, maar dat dit 'n noodsaaklike bydrae lewer om die werklikheid van die wetenskap te postuleer sonder om die gewaarwording tot subjektiwiteit te reduseer. Die objektiewe en die subjektiewe is nie twee geskeide domeine van die werklikheid nie, maar gee gelyktydig aan mekaar oorsprong. Laastens sal daarop gewys word dat selfbewussyn nie eenduidig is nie, maar in verhouding staan tot ander selfbewussyne.

This article will explore in what sense subject and object are considered reciprocally in Hegel's first three chapters in the Phenomenology of Spirit. The third chapter, although notoriously difficult to read, is one of the most important epistemological documents in modern philosophy. Hegel's approach will be traced within the debate stemming from Kant's transcendental philosophy mainly through Fichte and Schelling. It will be shown that Hegel incorporated elements from all these figures to arrive at his unique position. Kant's transcendental philosophy established the idea that the thinking consciousness contributes fundamentally to knowledge to the extent that knowledge is fully produced by the subject, and the true nature of the object is unattainable to consciousness. The widely held conclusion was that Kant S thought amounted to a too strong divide between subject and object. Fichte and Schelling managed, thanks to the notion of the absolute, to mediate between subject and object, thereby opening the door to Hegel's dialectics as a philosophy of mediation. Both Fichte and Schelling, as was the case, broadly speaking, with German Idealism taken as a whole, still considered thinking as an activity of being that contributes to the fulfilment of being, linking objects to consciousness. Fichte's "absolute I", a consciousness that precedes the consciousness of the self, standing over the self and the object, was deemed to resemble the Kantian subject too closely. Schelling's natural philosophy, on the other hand, situates the absolute within nature and consciousness as developing from within nature towards the deployment of the self. This approach was considered potentially falling back into a dogmatic mode of thinking. Even if these positions remain caught in problems they seek to overcome, they did make notable progress in addressing the question of the relation of the subject to the object in a modern context. Hegel develops his initial answer to this question in the Phenomenology of Spirit first as an inheritor of the Enlightenment, notably empiricism, but stands critical of its basic suppositions. He does not accept that complete knowledge is immediately accessible, and resorts to the notion of the Absolute to indicate that mediated knowledge leads to truth. Unlike Fichte, Reinhold and Schelling, he does not immediately introduce the absolute as a mediator of knowledge but arrives at it through counterarguments for the positions put forward by the assumption of immediate objective knowledge. This dialectic approach leads to the unfolding of consciousness, self-consciousness and Spirit. Our subjective contribution to knowledge production is also not assumed beforehand, like in Kant, but is the result of the confrontation with the assumptions made by experiential knowledge. Without subjectivity, knowledge of the unity of reality is impossible, as is knowledge of the difference between objects. Knowing objects according to their nature requires subjectivity from which order is established, but the subject experiences itself as standing in relation to objects. Consciousness is confronted by an outside world that must be made sense of. Not only is the establishment of the relation between subject and object important but according to Hegel, the subject's relation to the object is reflected in his self-understanding and self-consciousness. The notion of self-consciousness is revealed precisely by the relation between subject and object, but not before this relation. Hegel therefore starts his journey to the absolute through natural consciousness, a consciousness that takes immediate knowledge of objects around us as authoritative. One can call this immediate knowledge objective in the sense that it takes no queues from subjectivity. Hegel proceeds to critique objective knowledge, claiming that immediate knowledge doesn't reckon with the factor of time, and therefore cannot be the ultimate source of truth. This critique is ambivalent, as it does recognise the world of objects as a source for knowledge, however, this must be supplemented by our own consciousness in order to arrive at a deeper understanding of this knowledge. Consciousness becomes an essential ingredient necessary for understanding. The second chapter introduces perception as the measure of reality. Perception brings a multitude of things under a general principle, thereby creating an understanding between things and their general substance. This second approach to truth cannot explain how generality and particularity exist in the first place. Hegel moves to the notoriously difficult third chapter in which he describes the dynamic relation between force and understanding. Force is identified as the underlying dimension of external reality, but it has in turn to be postulated, making necessary the involvement of the understanding as hypothesising activity. At first, force is merely described in terms of its expressions, but acknowledgement of its fundamental trait as underlying the whole of physical reality without being a tangible thing, leads to the realisation of the role of the understanding. This realisation is self-consciousness. Self-consciousness becomes aware of its participative role in its determination of the underlying structures of reality, structures that are postulated, and not apparent. In the last section, it is pointed out that self-consciousness is not to be understood as standing alone concerning objects - self-consciousness also stands in relation to other-selves. Self-consciousness is not an object and cannot be fully determined as is the case with things. This does not form the primary concern of the article and will merely be described to point to the position of self-consciousness within the larger scheme of Hegel's thinking. This does not take away the importance that the topic under discussion here has for the development of Hegel's system, which is the reason for the focus given here.

Abstract: Catalan Jesuit Andrés Febrés’ Art of the General Tongue of the Kingdom of Chile (1765) contains the earliest examples of two explicitly Mapuche discourse genres. These are the ‘dialogue between two chiefs’ or dungulun and the ‘discourse’ or coyaghtun. Despite the role they were given as exemplification or protreptic texts, it remains clear that religious biases and a gaze from linguistic and cultural othering have produced a reimagining of the interactions and communities they seek to portray. This ‘clean-up’ of the material raises questions about their value as testimonies to Mapuche language and culture of the time. In this article we propose a critical reading of the material in which we seek out without denying foreign influence - the linguistic threads that may, with a modicum of certainty, be identified as part of contemporary speakers’ repertoires. This task is particularly relevant in current efforts to strengthen the role of textual sources in Mapudungun historical linguistics, that is, in establishing a philological tradition for the tongue. The novel method we propose entails the verification of historical linguistic material by contemporary native speakers of the language. As such, we present the results of a shared reading of the target texts, conducted by a historical linguist and a contemporary speaker. As a result, we highlight a series of under-described linguistic structures (lexicon, morphology, phonology, discourse) which show parallels between contemporary usage or lived memory and materials from over a quarter of a millennium ago.

Resumen: El Arte de la Lengua General del Reyno de Chile (1765), del jesuita Andrés Febrés, contiene los ejemplos más tempranos que poseemos de dos géneros discursivos explícitamente mapuches. Se trata del ‘diálogo entre dos caciques’ o dugulun y el ‘parlamento’ o coyaghtun. A pesar del rol ejemplificador o protréptico que se le da a este material, no cabe duda que el sesgo religioso y la mirada desde la otredad lingüística y cultural producen una reimaginación de la interacciones y las comunidades que se buscan caracterizar. Este ‘depuramiento’ del material pone en cuestión el valor del mismo en cuanto testimonio de la lengua y cultura mapuche de la época. En este artículo proponemos una lectura crítica del material en la cual buscamos, sin desmentir los elementos foráneos, seguir los hilos lingüísticos que podamos, con cierto grado de certeza, identificar como propios de los hablantes de la época. Esta tarea es particularmente relevante en los esfuerzos por fortalecer el rol del material textual en la lingüística histórica del mapudungun, esto es, de establecer una tradición filológica para la lengua. Proponemos como método innovador la verificación del material lingüísticos histórico por parte de los hablantes actuales. En tanto, presentamos los resultados de una lectura compartida de los dos textos en cuestión, realizada por un lingüista histórico y una hablante contemporánea. Destacamos una serie de elementos lingüísticos (léxico, morfología, fonología, discurso) poco descritos que muestran paralelos entre la usanza o memoria actual y los materiales de hace más de un cuarto de milenio.

Resumen En Argentina, el virus del dengue ha experimentado un aumento en los últimos años. Este estudio se propone realizar una revisión sistemática para evaluar la efectividad y seguridad de la vacuna TAK-003 tetravalente contra el dengue en este contexto. Se llevó a cabo una revisión sistemática de ensayos clínicos controlados aleatorizados que comparaban la efectividad y seguridad de la vacuna con placebo en la población general. La búsqueda se efectuó en Epistemonikos y dos investigadores evaluaron los estudios de manera independiente. El riesgo de sesgo se evaluó con la herramienta Rob 2 de Cochrane. Se realizó un metaanálisis de los resultados y la certeza en la evidencia se evaluó mediante la metodología GRADE. Concluimos, con alta certeza de evidencia, que la vacuna tetravalente contra el dengue reduce las infecciones graves (RR 0.17, IC 95% 0.12 a 0.24) e infecciones por el virus del dengue (RR 0.40, IC 95% 0.36 a 0.45) en una población de ≤17 años. La vacuna podría no incrementar el riesgo de eventos adversos serios, aunque es importante destacar la baja certeza de evidencia (RR 1.04, IC 95%: 0.69-1.55). La aplicación de la vacuna tetravalente contra el dengue disminuye el riesgo de infecciones graves y no graves por el dengue en esa población. No obstante, existe baja certeza en la evidencia en relación a la seguridad de la vacuna. La decisión de la vacunación debe considerar la magnitud de los beneficios en función del riesgo de infección.

Abstract In Argentina, the dengue virus has experienced an increase in recent years. This study aims to conduct a systematic review to assess the effectiveness and safety of the tetravalent dengue vaccine TAK-003 in this context. A systematic review of randomized controlled clinical trials comparing the effectiveness and safety of the vaccine with a placebo in the general population was conducted. The search was carried out on Epistemonikos, and two investigators independently evaluated the studies. Bias risk was assessed using Cochrane’s Rob 2 tool. A meta-analysis of the results was performed, and the certainty of evidence was evaluated using the GRADE methodology. We concluded, with high certainty of evidence, that the tetravalent dengue vaccine reduces severe infections (RR 0.17, 95% CI 0.12 to 0.24) and infections by the dengue virus (RR 0.40, 95% CI 0.36 to 0.45) in a population aged ≤17 years. The vaccine may not increase the risk of serious adverse events, although it is important to note the low certainty of evidence (RR 1.04, 95% CI: 0.69-1.55). The use of the tetravalent dengue vaccine decreases the risk of severe and non-severe dengue infections in this population. However, there is low certainty of evidence regarding the vaccine’s safety. The decision to vaccinate should consider the magnitude of benefits relative to the risk of infection.

Resumen En Argentina, el virus del dengue ha experimentado un aumento en los últimos años. Este estudio se propone realizar una revisión sistemática para evaluar la efec tividad y seguridad de la vacuna TAK-003 tetravalente contra el dengue en este contexto. Se llevó a cabo una revisión sistemática de ensayos clínicos controlados aleatorizados que comparaban la efectividad y seguridad de la vacuna con placebo en la población general. La búsqueda se efectuó en Episte monikos y dos investigadores evaluaron los estudios de manera independiente. El riesgo de sesgo se evaluó con la herramienta Rob 2 de Cochrane. Se realizó un metaa nálisis de los resultados y la certeza en la evidencia se evaluó mediante la metodología GRADE. Concluimos, con alta certeza de evidencia, que la vacuna tetravalente contra el dengue reduce las infec ciones graves (RR 0.17, IC 95% 0.12 a 0.24) e infecciones por el virus del dengue (RR 0.40, IC 95% 0.36 a 0.45) en una población de ≤17 años. La vacuna podría no incre mentar el riesgo de eventos adversos serios, aunque es importante destacar la baja certeza de evidencia (RR 1.04, IC 95%: 0.69-1.55). La aplicación de la vacuna tetravalente contra el dengue disminuye el riesgo de infecciones graves y no graves por el dengue en esa población. No obstante, existe baja certeza en la evidencia en relación a la se guridad de la vacuna. La decisión de la vacunación debe considerar la magnitud de los beneficios en función del riesgo de infección.

Abstract In Argentina, the dengue virus has experienced an increase in recent years. This study aims to conduct a systematic review to assess the effectiveness and safety of the tetravalent dengue vaccine TAK-003 in this context. A systematic review of randomized controlled clini cal trials comparing the effectiveness and safety of the vaccine with a placebo in the general population was conducted. The search was carried out on Epistemoni kos, and two investigators independently evaluated the studies. Bias risk was assessed using Cochrane’s Rob 2 tool. A meta-analysis of the results was performed, and the certainty of evidence was evaluated using the GRADE methodology. We concluded, with high certainty of evidence, that the tetravalent dengue vaccine reduces severe infections (RR 0.17, 95% CI 0.12 to 0.24) and infections by the den gue virus (RR 0.40, 95% CI 0.36 to 0.45) in a population aged ≤17 years. The vaccine may not increase the risk of serious adverse events, although it is important to note the low certainty of evidence (RR 1.04, 95% CI: 0.69-1.55). The use of the tetravalent dengue vaccine decreases the risk of severe and non-severe dengue infections in this population. However, there is low certainty of evidence regarding the vaccine’s safety. The decision to vaccinate should consider the magnitude of benefits relative to the risk of infection.

Abstract In forestry, accurate estimation of timber volume is essential for forest management in temperate forests. The objective of the present research was to generate equations of the total tree volume (Vtt), stem volume (Vs), and stem profile for Pinus ayacahuite, Pinus leiophylla, Pinus hartwegii, Pinus montezumae, Pinus patula, Pinus pseudostrobus, Pinus teocote, Abies religiosa and Quercus sp. in productive landscapes of a temperate ecosystem in the state of Puebla, Mexico. A sample of 1 676 trees was collected by destructive sampling. Based on the dendrometric type, the Vs, Vtt, and crown volume (Vc) were obtained. The volume of branches and twigs with diameters less than 5 cm was estimated using a xylometer and the Berkhout nonlinear model. The Schumacher-Hall model was fitted for the Vtt and the Vs with weighted regression in order to correct for heteroscedasticity. The Biging function was used to describe the stem profile, fitted with nonlinear generalized least squares to correct for autocorrelation. The goodness of fit of the equations are above 96 %, and the bias is below 0.04 m3. The statistical results show that the differential equation system predicts with certainty the Vtt, Vs, as well as the taper of commercial species in the temperate forests of Puebla, Mexico.

Resumen En silvicultura, la estimación precisa del volumen maderable es fundamental para el manejo forestal en bosques templados. El objetivo de la presente investigación fue generar ecuaciones de volumen total árbol (Vta), volumen fustal (Vf) y perfil del fuste para Pinus ayacahuite, Pinus leiophylla, Pinus hartwegii, Pinus montezumae, Pinus patula, Pinus pseudostrobus, Pinus teocote, Abies religiosa y Quercus sp. en paisajes productivos de un ecosistema templado en Puebla, México. Mediante un muestreo destructivo se recolectó una muestra de 1 676 árboles. Con base en el tipo dendrométrico se obtuvo el Vf, Vta y volumen de copa (Vc). Con un xilómetro y el modelo no lineal de Berkhout se estimó el volumen de ramas y ramillas con diámetros menores a 5 cm. Para Vta y Vf se ajustó el modelo Schumacher-Hall con regresión ponderada para corregir la heterocedasticidad. La función de Biging se usó para describir el perfil fustal, ajustado con mínimos cuadrados generalizados no lineales para corregir la autocorrelación. La bondad de ajuste de las ecuaciones fue superior a 96 % y un sesgo menor a 0.04 m3. Los resultados estadísticos muestran que el sistema de ecuaciones diferenciado predice con certidumbre el Vta, Vf y ahusamiento de las especies maderables comerciales en los bosques templados de Puebla, México.

Abstract In this study, we have carried out a variationist analysis of the use of mitigation resources in oral narrations of personal experiences both individually and conversationally constructed by speakers from Santiago de Chile. For this purpose, we have followed the model proposed in González Riffo yand Guerrero González (2017), who have classified the mitigation resources in three pragmatic axes: ‘certainty’, ‘veracity’, and ‘esteem’. The extralinguistic factors are the informants’ sex, their socioeconomic status, and the type of narrative construction. We have contrasted 36 individual narrations and 54 conversational (or co-constructed) narrations. Results have shown that speakers from high socioeconomic status mitigate more than those in medium or low status; females mitigate more than males in individual narrations; and, in conversational narrations, females mitigate less in those constructed by two males in comparison with those constructed by two females or a male and a female. Lastly, it is possible to observe that in individual narrations speakers mitigate less than in conversational narrations, which can be explained by a ‘conversational validation’ that can be found in the latter.

Resumen En este trabajo se realiza un análisis variacionista del empleo de recursos de atenuación en narraciones orales de experiencia personal construidas individual y conversacionalmente por hablantes de Santiago de Chile. Para esto, se sigue el modelo expuesto en González Riffo y Guerrero González (2017), quienes clasifican los recursos de atenuación según tres ejes pragmáticos: ‘certeza’, ‘veracidad’ y ‘estima’. Los factores extralingüísticos corresponden al sexo de los informantes, su grupo socioeconómico y el tipo de construcción narrativa. Se contrastan 36 narraciones individuales y 54 narraciones conversacionales (o co-construidas). Los resultados muestran que los hablantes del grupo socioeconómico alto atenúan más que los de los grupos bajo y medio; las mujeres atenúan más que los hombres en narraciones individuales; y en las conversacionales aquellas construidas por dos hombres presentan menos atenuadores que las construidas por dos mujeres y un hombre y una mujer. Por último, es posible observar que en las narraciones individuales los hablantes atenúan menos que en las conversacionales, lo que se explicaría por una ‘validación conversacional’ que es apreciable en las últimas.

Resumen La comida popular al alcance de las personas tiene relevancia social, nutricional e impacta en la salud de forma importante. Este trabajo aborda el uso tanto de la metodología del Design Thinking y de la teoría de la pirámide de la sostenibilidad para mejorar el valor nutritivo y saludable de un alimento popular, buscando al mismo tiempo conservar e incrementar el valor de ese alimento y beneficiar al consumidor. El análisis de la pirámide de sostenibilidad en el diseño de un alimento funcional utilizando la metodología Design Thinking enfatiza el valor nutricional para promover la participación en el diseño de alimentos nutritivos y saludables para la población. Al aplicar este método para el diseño y mejora de alimentos se cubren las expectativas básicas del usuario final de forma empática, permitiendo obtener una mayor certidumbre respecto al emprendimiento en nuevos productos alimentarios con un enfoque sustentable.

Abstract Popular food available to people has social and nutritional relevance and impacts health in an important way. This work addresses the use of both the Design Thinking methodology and the sustainability pyramid theory to improve the nutritional and healthy value of a popular food, seeking at the same time to preserve and increase the value of that food and benefit the consumer. The analysis of the sustainability pyramid in the design of a functional food using the Design Thinking methodology emphasizes nutritional value to promote participation in the design of nutritious and healthy foods for the population. By applying this method to the design and improvement of food, the basic expectations of the end user are met in an empathetic way, allowing greater certainty to be obtained regarding entrepreneurship in new food products with a sustainable approach.

Abstract Introduction : Coverage for colorectal cancer screening in Argentina is very low. The objective of this review is to assess and synthesize the evidence on the effectiveness of strategies aimed at increasing adherence to colorectal cancer screening among healthcare personnel and the general population at average risk. Methods : A review of systematic reviews (SRs) that evaluated the effectiveness of these strategies was con ducted. Searches were performed in electronic data bases, meta-search engines, the Cochrane Library, and through manual searching. Eligibility and inclusion criteria were applied, with assessment of the quality of the SRs using AMSTAR II and the certainty of evidence using the GRADE approach. Thematic synthesis was con ducted based on the taxonomy of strategies proposed by Dougherty (patient/community-targeted, professional-targeted, and other types of strategies). Results : A total of 635 studies were identified, with 36 deemed eligible and 11 excluded due to insufficient quality, resulting in the inclusion of 10 SRs. A multi plicity of strategies with varying effectiveness were identified, with the majority targeting the population. Among these, education, self-testing with specimen collection at specific locations, and reminders stood out. For professionals, only education and reminders showed effectiveness. Combined strategies demonstrated greater effectiveness than isolated strategies. Conclusions : There is more evidence on strategies targeting the population than professionals. Combined strategies showed greater effectiveness, highlighting the need to explore barriers in both the population and professionals in each specific context in order to priori tize and combine those that have proven effective and would have a greater impact.

Resumen Introducción : En Argentina la cobertura al tamizaje de cáncer colorrectal (CCR) es muy baja. El objetivo de esta revisión fue relevar y sintetizar la evidencia sobre la efectividad de estrategias dirigidas a incrementar la adherencia al tamizaje de CCR del personal de salud y población con riesgo promedio. Métodos : Revisión de revisiones sistemáticas (RS) que evaluaron la efectividad de dichas estrategias. Bús queda en bases de datos electrónicas, meta-buscadores, biblioteca Cochrane y búsqueda manual. Aplicación de criterios de elegibilidad e inclusión; con evaluación de la calidad de las RS a través del AMSTAR-II y la certeza de la evidencia por el método GRADE. Síntesis temática sobre la base de la taxonomía de estrategias propuesta por Dougherty (dirigidas al paciente/comunidad; a pro fesionales; otro tipo de estrategias). Resultados : Se identificaron 635 estudios; 36 fueron elegibles y 11 se descartaron por no contar con cali dad suficiente, incluyéndose 10 RS. Se identificó una multiplicidad de estrategias de efectividad variada, la mayoría dirigida a la población. Entre estas, destacan la educación, el auto-test con recolección en lugares específicos y recordatorios. En el caso de profesionales, solo educación y recordatorios mostraron ser efectivas. La combinación de estrategias mostró tener mayor efec tividad que las estrategias aisladas. Conclusiones : Es mayor la evidencia sobre estrategias dirigidas a la población que a profesionales. Las estrate gias combinadas demostraron tener mayor efectividad, lo que destaca la necesidad de explorar, en cada con texto, las barreras en la población y en los profesionales para priorizar y combinar aquellas que demostraron ser efectivas y tendrían mayor impacto.

Resumen El presente artículo analiza uno de los temas trascendentales que todo país que aspira seguir la senda del desarrollo económico debe enfrentar, este es, el relativo a la seguridad, celeridad y eficiencia que el sistema registral respectivo otorga al tráfico jurídico inmobiliario. En efecto, el actual dinamismo económico exige una libre circulación de la riqueza en todo ámbito; es decir, en lo que atañe a esta investigación, que las operaciones inmobiliarias sean expeditas y que el Derecho Registral Inmobiliario otorgue una adecuada seguridad jurídica a los agentes que intervienen en ellas. En este sentido, la presente investigación tiene por objeto determinar si el sistema registral chileno otorga la debida seguridad jurídica al tráfico inmobiliario en su respectivo registro de propiedad y en la calificación registral. Para cumplir con ese objetivo, se exponen algunas particularidades presentes en nuestro sistema, considerando la normas legales y reglamentarias actualmente vigentes en cuanto al catastro inmobiliario.

Abstract The article analyses one of the transcendental issues that every country that aspires to follow the path of economic development must face, that is, the security, speed, and efficiency that the respective registry system grants to the real estate legal traffic. In fact, the current economic dynamism demands a free circulation of wealth in all areas as far as this research is concerned, that real estate transactions be expeditious and that the Real Estate Registry Law grants an adequate legal security to the agents involved in them. In this sense, the purpose of this research is to determine whether the Chilean registry system provides adequate legal certainty to the real estate traffic in its respective property registry and in the registry qualification. To meet this objective, some particularities present in our system are presented, considering the legal and regulatory norms currently in force regarding the real estate cadaster.

Abstract In Paraguay, even if the doctrine of "stare decisis" does not apply, jurisprudence still plays an important role in generating legal certainty through the uniform application of the law in the courts. This occurs thanks to the work of the Supreme Court of Justice, which, as the highest judicial instance, rules on the validity of judicial resolutions issued by courts and tribunals. This position in the judicial pyramid has a persuasive effect on the other jurisdictional bodies, generating a system of interpretation and uniform application of the law. However, at present, courts and tribunals make little use of the rulings handed down by the Supreme Court. The consequence is a judicial system with contradictory rulings, which fails in its duty to generate legal certainty. In this article we seek to analyze the causes of this situation and propose possible solutions to overcome it. Among these, the proposal to implement a simple access tool to the Court's rulings to facilitate their use is to be highlighted. In this way, this article intends to help generate legal certainty in the country, in order to guarantee the rule of law.

Resumen Aunque en Paraguay no rige la doctrina del “stare decisis”, la jurisprudencia igualmente juega un rol importante en la generación de seguridad jurídica, a través de la uniforme aplicación de la ley en los tribunales. Esto ocurre gracias al trabajo de la Corte Suprema de Justicia que, en su carácter de máxima instancia judicial, resuelve sobre la validez de las resoluciones judiciales dictadas por tribunales y juzgados. Esa posición en la pirámide judicial asume un efecto persuasivo en los demás órganos jurisdiccionales, generando un sistema de interpretación y aplicación uniforme de la ley. Sin embrago, en la actualidad, tribunales y juzgados utilizan escasamente los fallos dictados por la Corte Suprema. La consecuencia es un sistema judicial con sentencias contradictorias, que incumple con su deber de generar seguridad jurídica. En este artículo buscamos analizar las causas de esta situación, y proponemos posibles soluciones para su superación. Entre estas, se destaca la propuesta de implementación de una herramienta de acceso simple a las sentencias de la Corte para facilitar su utilización. De esa manera, se pretende ayudar a generar seguridad jurídica en el país, para así garantizar el estado de derecho.