Abstract The main causes of poor performance of cement-treated crushed stones (CTCS) pavement layers are material-related heterogeneity, porosity, and brittle cementitious matrix, leading to fast fatigue degradation. Seeking to improve CTCS mechanical properties and structural response it was studied different grading curves such as DER-SP, EN 14227-1 CBGM 2 and RCC-ACI were studied. The aim of the laboratory study was to rank and select among the classical particle size distribution models like Talbot & Richart, and analytical models as compressible packing model – CPM, the best grading curve which was capable of producing mixtures with the best aggregate interlocking and improved mechanical resistances. The effect of cement content (4% and 5%) as well as the potential of using silica fume in suspension (percentages of 5, 7 and 10% of cement mass) to improve the interfacial transition zone were evaluated. It was found that CPM is a powerful tool for aggregates ranking aggregates and designing well-graded mixtures like CTCS; the CBGM 2 EN 14227-1 mean curve achieved the best packing density. The effect of increasing the cement content from 4 to 5% in terms of mechanical strength has the same result as the addition of 7% of silica fume in mixtures with 4% cement. Eventually, mixtures with 5% cement and 10% silica fume showed modulus of elasticity similar to traditional CTCS; nonetheless, the HP-CTCS (high performance CTCS) split tensile strength was significantly higher (about 28%), leading to a lower Et,sp/fct,sp relationship, which is a highly positive outcome to improve mechanical durability of this innovative dry compacted concrete. cementtreated treated (CTCS materialrelated material related heterogeneity porosity matrix degradation DERSP, DERSP DER SP, SP DER-SP 142271 14227 1 14227- RCCACI RCC ACI Richart resistances (4 5 percentages 10 mass evaluated wellgraded graded density Eventually nonetheless HPCTCS HP high about 28%, 28 28% , 28%) Etspfctsp Et sp fct relationship concrete 1422 ( 142 14

Resumo As principais causas do desempenho insatisfatório de bases de brita graduada tratada com cimento (BGTC) está relacionada à sua matriz cimentícia heterogênea, porosa e frágil que favorece o processo de degradação por fadiga. Assim, buscando melhorar as propriedades mecânicas e resposta estrutural da BGTC, o presente estudo avaliou diferentes faixas granulométricas (DER-SP, CBGM 2 EN 14227-1 e CCR-ACI) através de modelos clássicos de distribuição de partículas como Talbot & Richart e modelo analítico do empacotamento compressível (compressible packing model – CPM) para classificar e selecionar curvas granulométricas capazes de potencializar o empacotamento das partículas e melhorar a resistência mecânica da mistura. O efeito do teor de cimento (4 e 5%) foi avaliado, bem como o potencial de se utilizar sílica ativa em suspensão (em porcentagens de 5, 7 e 10% da massa de cimento) para modificar a zona de transição interfacial. Verificou-se que o CPM é uma poderosa ferramenta para a seleção e projeto de misturas bem graduadas; a curva média para a faixa CBGM 2 da norma Europeia EN 14227-1 apresentou a maior densidade de empacotamento. O efeito do aumento do teor de cimento de 4% para 5%, em termos de resistência mecânica, poderia ser compensado pela adição de 7% de sílica ativa à mistura com 4% de cimento. Por fim, misturas com 5% de cimento e 10% de sílica ativa apresentaram valores de módulo de elasticidade muito similares àqueles tradicionalmente obtidos para BGTC; contudo, a resistência à tração indireta da BGTCAD foi significativamente maior (em torno de 28%), levando à uma relação modular (Et,sp/fct,sp) menor, o que é promissor em termos durabilidade mecânica para esse tipo de concreto seco. BGTC (BGTC heterogênea fadiga Assim DERSP, DERSP DER SP, SP (DER-SP 142271 14227 1 14227- CCRACI CCR ACI CCR-ACI compressible 4 ( 5 avaliado 10 interfacial Verificouse Verificou graduadas fim contudo 28%, 28 28% , 28%) Et,sp/fct,sp Etspfctsp Et sp fct (Et,sp/fct,sp menor seco 1422 142 14

ABSTRACT The objective of this study was to determine the energy values and standardized ileal digestibility (SID) of amino acids of corn, corn protein meal (CPM), corn germ (CG), and dried distillers' grains with solubles (DDGS) in broiler diets. In the first experiment, the apparent metabolizable energy (AME) and nitrogen-corrected apparent metabolizable energy (AMEn) values were determined using the total excreta collection method. A total of 240 14-day-old broiler chicks were randomly distributed in a completely randomized design with five treatments, including four different feed ingredients and a reference diet, each with eight replicates of six birds. In the second experiment, to determine the coefficient values of amino acids, 240 birds aged 14 to 28 days were randomly assigned to five treatments, including four different feed ingredients and a nitrogen-free diet, each with eight replicates of six birds. At 28 days of age, birds were slaughtered, and the digesta were collected to determine the standardized ileal digestibility coefficients and, subsequently, the digestibility of amino acids. The AMEn for corn, CPM, CG, and DDGS is 3178, 2171, 2473, and 3398 kcal/kg, respectively. The metabolizability coefficient of the AMEn percentages are 68.03% for corn, 46.62% for CPM, 44.15% for CG, and 73.39% for DDGS. The average digestibility of essential amino acids in corn, CPM, CG, and DDGS is 92.55, 52.63, 73.07, and 81.51%, respectively. For non-essential amino acids, the average digestibility in corn, CPM, CG, and DDGS is 90.59, 54.36, 70.20, and 79.47%, respectively, with an overall average of 85.21%. SID (SID CPM , (CPM) CG (CG) distillers (DDGS diets experiment AME (AME nitrogencorrected nitrogen corrected (AMEn method 24 14dayold dayold day old treatments diet 1 2 nitrogenfree free age slaughtered subsequently 3178 2171 2473 339 kcalkg kcal kg kcal/kg respectively 6803 68 03 68.03 4662 46 62 46.62 4415 44 15 44.15 7339 73 39 73.39 9255 92 55 92.55 5263 52 63 52.63 7307 07 73.07 8151 81 51 81.51% nonessential non 9059 90 59 90.59 5436 54 36 54.36 7020 70 20 70.20 7947 79 47 79.47% 8521 85 21 85.21% (CPM (CG 317 217 247 33 680 6 0 68.0 466 4 46.6 441 44.1 733 7 3 73.3 925 9 5 92.5 526 52.6 730 73.0 815 8 81.51 905 90.5 543 54.3 702 70.2 794 79.47 852 85.21 31 68. 46. 44. 73. 92. 52. 81.5 90. 54. 70. 79.4 85.2 81. 79. 85.

Abstract This article tackles the forms of appropriation of the recent past by new generations through the analysis of a corpus composed of productions made by youth groups from different localities of the province of Buenos Aires, performed within the framework of the Jóvenes y Memoria program organized by the CPM since the year 2002. The goal is to demonstrate that the transmission of the past to the new generations is not limited to the teaching of history or a legacy of lessons, but that it is possible for new generations to establish themselves as active subjects in the process of elaboration of past experiences. These re-elaborations pick up stories, protagonists and pieces of the past that are not part of the canonical memories that are prominent in the public sphere and in school.

Resumen El artículo aborda las formas de apropiación de las nuevas generaciones del pasado reciente a través del análisis de un corpus compuesto por producciones de grupos de jóvenes de distintas localidades de la provincia de Buenos Aires realizadas en el marco de la experiencia del Programa Jóvenes y memoria articulado por la Comisión Provincial por la Memoria desde el año 2002. Lo que se pretende demostrar es que la transmisión del pasado a las nuevas generaciones no se reduce a la enseñanza de la historia o al legado de lecciones, sino que es posible que las nuevas generaciones se constituyan en sujetos activos en el proceso elaboración de las experiencias pasadas, de modo tal que las reconstruyan recogiendo historias, protagonistas y dimensiones del pasado que no son parte de las memorias canonícas que mayor predominancia tienen en la esfera pública y en la escuela.

Abstract This paper evaluates the impact of government support and containment measures on the manufacturing production cycle (MPC) of 39 countries during the COVID-19 pandemic. To the best of our knowledge, the effects of these variables on the MPC have not been studied. To obtain reliable evidence, we resort to two complementary econometric techniques: the Arellano-Bond Generalized Method of Moments (GMMs) and the Arellano-Bover GMMs. The evidence is consistent across econometric methods in showing that: 1) Closure and containment measures have been recessionary, 2) Income support measures and interest rate cuts have been effective in raising manufacturing production, and 3) Real exchange rate depreciations do not stimulate (and could even discourage) manufacturing production, presumably because they make imported intermediate inputs more expensive. Therefore, raising consumption through higher income and investment through lower interest rates can alleviate the recessionary effects of closure and containment policies, whereas depreciating the currency may not be effective to boost manufacturing production amid falling world trade and disrupted global supply chains, which could interact with a weaker currency to make imported intermediate inputs even more costly.

Resumen Este trabajo evalúa el impacto de las medidas de reactivación económica y de contención de la pandemia de COVID-19 en el ciclo de la producción manufacturera (CPM) de 39 naciones. El impacto de estas variables en el CPM no ha sido estudiado. Para obtener evidencia robusta, se emplea el Método Generalizado de Momentos en dos versiones: la Arellano-Bond y la Arellano-Bover. La evidencia indica que: 1) Las medidas de cierre y contención han sido recesivas, 2) Las medidas de apoyo al ingreso y los recortes de tasas de interés han reactivado la producción manufacturera, y 3) Las depreciaciones cambiarias reales no estimulan (e incluso podrían desalentar) la producción manufacturera al encarecer los insumos intermedios importados. Esto implica que los efectos recesivos de las medidas de contención pueden efectivamente atenuarse mediante recortes de tasas de interés para incentivar la inversión y mediante apoyo a los ingresos para elevar el consumo. Asimismo, las depreciaciones cambiarias pueden no estimular la producción con un comercio mundial en caída y cadenas globales de valor interrumpidas, que tienden a encarecer todavía más los insumos intermedios importados.

Resumen Introducción: Las malformaciones pulmonares congénitas son poco frecuentes en niños. El objetivo de este estudio fue describir las características clínicas, imagenológicas y tratamiento de los pacientes con esta patología. Métodos: Se llevó a cabo un estudio descriptivo y retrospectivo con datos de los pacientes con malformaciones pulmonares congénitas diagnosticados en el Instituto Nacional de Salud del Niño-Breña (Lima-Perú) entre enero 2010 y diciembre 2020. Se describieron las características clínicas, imagenológicas, el tipo de malformación pulmonar congénita y el tratamiento. Resultados: La muestra fue de 70 pacientes. La mediana de edad fue 29 meses, la relación masculino/femenino fue 1.4. En la tomografía de tórax se encontró compromiso parenquimal en 50 (71.4%) casos, y compromiso mixto (parenquimal y vascular) en 18 (25.7%). La malformación congénita de la vía aérea pulmonar se observó en 39 (55.7%) casos, seguida del quiste broncogénico en 10 (14.3%), secuestro pulmonar intralobar en 9 (12.9%) y secuestro pulmonar extralobar en 7 (10%). La lobectomía fue realizada en 61 (87.1%) casos, la quistectomía en 5 (7.1%), segmentectomía en 2 (2.9%) y embolización en 2 (2.9%). La complicación posquirúrgica más frecuente fue la neumonía en 9 (12.9%) casos. La mediana de estancia hospitalaria fue de 26 días. Ningún paciente falleció durante la hospitalización. Conclusiones: En nuestra institución, la malformación pulmonar congénita más frecuente fue la malformación congénita de la vía aérea pulmonar, y la lobectomía el procedimiento quirúrgico más comúnmente realizado. Las malformaciones pulmonares congénitas representan un grupo diverso de trastornos del desarrollo pulmonar con variados patrones imagenológicos y manifestaciones clínicas.

Abstract Background: Congenital pulmonary malformations (CPMs) are rare in children. This study aimed to describe the clinical, imaging characteristics, and treatment of patients with this pathology. Methods: We conducted a descriptive and retrospective study with data from patients with CPMs diagnosed at Instituto Nacional de Salud del Niño-Breña (Lima-Peru), from January 2010 to December 2020. We described CPM clinical and imaging characteristics, type and treatment. Results: The sample was formed of 70 patients. The median age was 29 months (range 15 days-14 years) and the male/female ratio was 1.4. The chest tomography found parenchymal involvement in 50 (71.4%) cases and mixed involvement (parenchymal and vascular) in 18 (25.7%) cases. Congenital malformation of the pulmonary airway was present in 39 (55.7%) cases, followed by bronchogenic cyst in 10 (14.3%), intralobar pulmonary sequestration in 9 (12.9%), and extralobar pulmonary sequestration in 7 (10%). Lobectomy was performed in 61 (87.1%) cases, cystectomy in 5 (7.1%), segmentectomy in 2 (2.9%), and embolization in 2 (2.9%). The most frequent post-operative complication was pneumonia, found in 9 (12.9%) cases. The median hospital stay was 26 days. No patient died during hospitalization. Conclusions: In our institution, the most frequent CPM was congenital malformation of the pulmonary airway, and lobectomy was the most frequently performed surgical procedure. CPMs represent a diverse group of disorders of lung development with varied imaging patterns and clinical manifestations.

ABTRACT Introduction: Recent efforts in the diagnosis of SARS-CoV-2 have focused on the development of rapid tests for the detection of SARS-CoV-2 antigens (RTD-Ag), due to the low cost of these methods and the speed to provide a primary diagnosis at the point of care outside the laboratory. In this study, the utility of five methods for detecting the nucleocapsid protein (N) of SARS-CoV-2 as an antigen (Ag) for the positive diagnosis of this virus was evaluated. Methods: Five kits for the detection of SARS-CoV-2 Ag based on two molecular principles (immunochromatography and immunofluorescence) were evaluated. A total of 587 samples from nasal and nasopharyngeal swab of patients confirmed by RT-PCR to SARS-CoV-2 and negative samples to this virus were analyzed. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), concordance and Kappa index parameters were calculated for each assay evaluated. Results: The ABBOTT, CPM, CORE and WANTAI SARS-CoV-2 (IFA) assays performed well (sensitivity: 80-95 % and specificity 90-98 %) when evaluated with samples from suspected patients. In the KEWEI trial, the results of these parameters differed (75 % sensitivity and 90 % specificity) from those recommended by the WHO. According to the Kappa index rating scale, all the trials analyzed showed good and very good agreement. Conclusions: The results obtained in this research support the utility of the tests evaluated and their use in the network of laboratories for the diagnosis of SARS-CoV-2.

RESUMEN Introducción: Los esfuerzos recientes en el diagnóstico del SARS-CoV-2 se han centrado en el desarrollo de pruebas rápidas de detección de antígenos SARS-CoV-2 (PRD-Ag), debido al bajo costo de estos métodos y a la rapidez para brindar un diagnóstico primario en el punto de atención médica fuera del laboratorio. En este estudio se evaluó la utilidad de cinco métodos de detección de la proteína de la nucleocápside (N) del SARS-CoV-2 como antígeno (Ag) para el diagnóstico de este virus. Métodos: Se evaluaron cinco estuches para la detección de Ag SARS-CoV-2 basados en dos principios moleculares (inmunocromatografía e inmunofluorescencia). Se analizó un total de 587 muestras procedentes de exudado nasal y nasofaríngeo de pacientes confirmados por la Reacción en Cadena de la Polimerasa en Tiempo Real (RT-PCR) al SARS-CoV-2 y muestras negativas a este virus. Se calcularon los parámetros de sensibilidad, especificidad, Valor Predictivo Positivo (VPP), Valor Predictivo Negativo (VPN), concordancia e índice Kappa para cada ensayo evaluado. Resultados: Los ensayos ABBOTT, CPM, CORE y WANTAI SARS-CoV-2 (IFA) presentaron un buen desempeño (sensibilidad: 80-95 % y especificidad 90-98 %) al ser evaluados con muestras de pacientes sospechosos. En el ensayo KEWEI los resultados de estos parámetros difirieron (sensibilidad del 75 % y especificidad del 90 %) de los recomendados por la OMS. Según la escala de valoración del índice de Kappa, todos los ensayos analizados presentaron un grado de concordancia Buena y Muy buena. Conclusiones: Los resultados obtenidos en la presente investigación, avalan la utilidad de los ensayos evaluados y su uso en la red de laboratorios para el diagnóstico del SARS-CoV-2.

ABSTRACT BACKGROUND AND OBJECTIVES: The hormonal impact on pain perception during the menstrual cycle is a major focus of study, and further elucidation in temporomandibular disorders (TMD) field is necessary. Thus, this cross-sectional study evaluated experimental pain thresholds, psychosocial features, and clinical pain report on TMD women across menstrual cycle versus healthy controls. METHODS: A total of 220 women’s clinical files were screened, with 80 selected and divided into control group (healthy individuals, n=40) and TMD group (myofascial pain, n=40). Regarding the menstrual cycle phases, the files were divided into Pre-Luteal and Luteal. The Perceived Stress Scale (PSS), Pain Catastrophizing Scale (PCS), Mechanical Pain Threshold (MPT), Wind-up (WUR), Pressure Pain Threshold (PPT), Conditioned Pain Modulation (CPM) and Visual Analogue Scale (VAS) were analyzed at a 5% significance level, by Two-Way ANOVA test and post hoc Tukey test. RESULTS: PSS and PCS were significantly different between TMD and control group (p<0.001), regardless of menstrual cycle. Healthy individuals in the Luteal phase presented higher MPT values compared to the other phases (p<0.001). PPT showed significant difference across menstrual phases (p=0.022), but no differences in multiple comparisons. VAS values showed no difference between menstrual cycle phases (p=0.376). CONCLUSION: Finally, healthy individuals in the Luteal phase have higher MPT and PPT values on the orofacial region. Pain report in patients with TMD showed no difference throughout the menstrual cycle, showing that small alterations on experimental pain thresholds may not be clinically relevant. The presence of chronic pain seems to be more related to psychosocial features than hormonal fluctuations. OBJECTIVES (TMD necessary Thus crosssectional cross sectional controls METHODS 22 womens s screened 8 n=40 n40 n 40 myofascial n=40. . PreLuteal Pre PSS, , (PSS) PCS, (PCS) MPT, (MPT) Windup Wind up WUR, WUR (WUR) PPT, (PPT) CPM (CPM (VAS 5 level TwoWay Two Way RESULTS p<0.001, p0001 p p<0.001 0 001 (p<0.001) p<0.001. p=0.022, p0022 p=0.022 022 (p=0.022) comparisons p=0.376. p0376 p=0.376 376 (p=0.376) CONCLUSION Finally region relevant fluctuations 2 n=4 n4 4 (PSS (PCS (MPT (WUR (PPT p000 p<0.00 00 (p<0.001 p002 p=0.02 02 (p=0.022 p037 p=0.37 37 (p=0.376 n= p00 p<0.0 (p<0.00 p=0.0 (p=0.02 p03 p=0.3 3 (p=0.37 p0 p<0. (p<0.0 p=0. (p=0.0 (p=0.3 p<0 (p<0. p=0 (p=0. p< (p<0 p= (p=0 (p< (p= (p

RESUMO JUSTIFICATIVA E OBJETIVOS: O impacto do ciclo menstrual na percepção da dor é um foco importante de estudo, sendo necessária uma maior elucidação na disfunção temporomandibular (DTM). Assim, este estudo transversal avaliou limiares de dor experimental, características psicossociais e relatos de dor em mulheres com DTM ao longo do ciclo menstrual, comparadas com controles saudáveis. MÉTODOS: 220 prontuários de mulheres foram analisados, sendo 80 selecionados para os grupos de controle (saudáveis, n=40) e DTM (dor miofascial, n=40). Nas fases do ciclo menstrual, as pacientes foram divididas nas categorias Pré-Luteal e Luteal. Os instrumentos Escala de Estresse Percebido (PSS), Escala de Pensamentos Catastróficos (PCS), Limiar de Dor Mecânica (MPT), Wind-up Ratio (WUR), Limiar de Dor à Pressão (PPT), Modulação Condicionada da Dor (CPM) e Escala analógica visual (EAV) foram analisados com nível de significância de 5%, pelos testes ANOVA de dois fatores e Tukey post hoc. RESULTADOS: As escalas PSS e PCS foram significativamente diferentes entre os grupos DTM e controle (p<0,001), independentemente do ciclo menstrual. Indivíduos saudáveis na fase luteal apresentaram MPT maior em comparação com outras fases (p,0,001). O PPT mostrou diferença significativa entre as fases menstruais (p=0,022), sem diferença nas comparações múltiplas. Os valores da EAV não apresentaram diferença entre as fases menstruais (p=376). CONCLUSÃO: Indivíduos saudáveis na fase luteal têm MPT e PPTl maior na região orofacial. Os relatos de dor em pacientes com DTM não mostraram diferença ao longo do ciclo menstrual, indicando que pequenas alterações nos limiares experimentais podem ser clinicamente relevantes. A presença de dor crônica parece estar mais relacionada com características psicossociais do que com flutuações hormonais. OBJETIVOS DTM. . (DTM) Assim experimental MÉTODOS 22 8 saudáveis, (saudáveis n=40 n40 n 40 miofascial n=40. PréLuteal Pré Luteal PSS, , (PSS) PCS, (PCS) MPT, (MPT) Windup Wind up WUR, WUR (WUR) PPT, (PPT) CPM (CPM (EAV 5 5% hoc RESULTADOS p<0,001, p0001 p p<0,001 0 001 (p<0,001) p,0,001. p,0,001 (p,0,001) p=0,022, p0022 p=0,022 022 (p=0,022) múltiplas p=376. p376 p=376 376 (p=376) CONCLUSÃO orofacial relevantes hormonais (DTM 2 n=4 n4 4 (PSS (PCS (MPT (WUR (PPT p000 p<0,00 00 (p<0,001 p,0,00 (p,0,001 p002 p=0,02 02 (p=0,022 p37 p=37 37 (p=376 n= p00 p<0,0 (p<0,00 p,0,0 (p,0,00 p=0,0 (p=0,02 p3 p=3 3 (p=37 p0 p<0, (p<0,0 p,0, (p,0,0 p=0, (p=0,0 p= (p=3 p<0 (p<0, p,0 (p,0, p=0 (p=0, (p= p< (p<0 p, (p,0 (p=0 (p (p< (p,

This study aims to describe how the advanced campus of Patos de Minas (CPM) of the Federal University of Uberlândia (UFU) is managed, identify and analyze the positive and negative aspects of the administrative management model adopted. This is a qualitative study developed from semi-structured interviews with servers with experience in university management, and online sessions that obtained 298 participants (45.78% of the CPM faculty, students and technicians). The research followed Bardin's content analysis guidelines. As a result, it was concluded that the CPM presents a bureaucratic administrative management, but with elements of the political model in its decision-making processes. The main positive points are the good relationship and dialogue between the CPM and the headquarters and among the negative aspects are the low autonomy and high centralization in the management of the Patos de Minas campus. Among the main recommendations for improvement pointed out by the study, the following stand out: bringing the decision-making structure closer to the student, increasing the decision-making power of local managers, formalizing a policy of good relationship between the advanced campus and the headquarters, and making administrative management more flexible.

Este estudio tiene como objetivo describir cómo se gestiona el campus avanzado de Patos de Minas (CPM) de la Universidad Federal de Uberlândia (UFU), para identificar y analizar las fortalezas y debilidades del modelo de gestión administrativa adoptado. Se trata de un estudio cualitativo desarrollado a partir de entrevistas semiestructuradas a funcionarios, con experiencia en gestión universitaria, y cuestionarios online que obtuvieron 298 participantes (45,78% del profesorado, estudiantes y técnicos del CPM). La investigación siguió las pautas de análisis de contenido de Bardin. Como resultado, se concluyó que el CPM presenta una gestión administrativa mayoritariamente burocrática, pero con fuertes elementos del modelo político en sus procesos de toma de decisiones. Las principales fortalezas involucran la buena relación y diálogo entre el CPM y la sede y entre los puntos negativos se destaca la baja autonomía y alta centralización en la gestión del campus de Patos de Minas. Entre las principales recomendaciones de mejora señaladas por el estudio destacan: acercar la estructura de toma de decisiones al alumno, incrementar el poder de decisión de los gestores locales, formalizar una política de buena relación entre el campus avanzado y el sede y flexibilización de la gestión administrativa.

Este estudo visa descrever como é administrado o campus avançado de Patos de Minas (CPM) da Universidade Federal de Uberlândia (UFU) e analisar os aspectos positivos e negativos do modelo de gestão administrativa adotado. Trata-se de um estudo qualitativo desenvolvido a partir de entrevistas semiestruturadas com servidores, com experiência em gestão universitária, e questionários online que obteve 298 participantes (45,78% do corpo docente, discente e técnico do CPM). A pesquisa observou as diretrizes da análise de conteúdo de Bardin. Como resultados, concluiu-se que o CPM apresenta uma gestão administrativa burocrática, mas com elementos do modelo político em seus processos de tomada de decisão. Os principais aspectos positivos envolvem o bom relacionamento e diálogo entre o CPM e a sede e entre os aspectos negativos destacam-se a baixa autonomia e elevada centralização na gestão do campus Patos de Minas. Dentre as principais recomendações de melhoria apontadas pelo estudo, destacam-se: aproximar a estrutura decisória do estudante, aumentar o poder de decisão dos gestores locais, formalizar política de bom relacionamento entre o campus avançado e a sede e flexibilizar a gestão administrativa.

ABSTRACT The Triplet-Septet (TS) set of melon cucurbit powdery mildew (CPM) race differentials (CPMRD) was established to provide an international means for objective and uniform identification and designation on CPM races. The Area Under Disease Progress Stairs (AUDPS) method for disease progress estimation was derived from the Area Under Disease Progress Curve (AUDPC) method, and both have been used to evaluate disease progress on other crops. We aimed to identify a melon CPM race on the TS melon CPMRD, and estimate disease progress thereon using AUDPC and AUDPS. Plants were inoculated at the 3 to 4 true leaf stage. Severity of CPM infection was evaluated on the 21 TS melon CPMRD at 15, 22, 32, and 41 days after inoculation (DAI) using a visual scale. The CPM population in the greenhouse was identified as race S based on reactions of a set of 11 commonly used melon CPMRD, and it may also be designated as 127.127.126 on the TS melon CPMRD. AUDPS identified higher levels of disease than AUDPC, and its results agreed with those obtained by the commonly used melon CPMRD conventional race identification methods (current and Triplet-Septet). AUDPS can be used to evaluate the disease progress on CPM. TripletSeptet Triplet Septet (TS (CPM (CPMRD races (AUDPS (AUDPC crops stage 2 15 22 32 DAI (DAI scale 1 127127126 127 126 127.127.12 current TripletSeptet. . Triplet-Septet) 12712712 12 127.127.1 1271271 127.127. 127127 127.127 12712 127.12 1271 127.1 127.

Abstract: Capability analysis seeks to estimate the probability that a process will produce compliant products. The capability indices are dimensionless parameters that measure how well the process can meet specifications. In the literature, eight capability indices are listed, among others, considering a stable process under statistical control and based on the normal probability distribution, defined by: Cp, Pp, Cpk, Ppk, Cpm, Ppm, Cpmk, and Ppmk. Basically, the index formulas differ in the calculations of the variability within and total, and of the shifts of the mean in relation to the nominal value and the nearest specification limit. The objective of this article was to compare these capacity indexes, and for that, it was chosen the most consistent estimator, that is, the one that improved the accuracy and efficiency as the number of observations increased. Thus, a simulation of 30,000 values of a normal random variable with a mean equal to zero and a standard deviation equal to one was performed. This made it possible to sample this process 1,000 times using 5, 10, 15, 20, 25, and 30 rational subgroups with individual observations or sample elements. Subsequently, 20 mean shifts were provoked, with values ranging from 0.1 to 2 and varying by 0.1 unit. According to the results, it was concluded that the indexes Cpk and Ppk were the most consistent in presenting higher accuracy and efficiency for at least 15 rational subgroups or sample elements, regardless of the magnitude of the mean displacement in relation to the nominal value. Abstract products specifications literature listed others distribution Cp Pp Cpm Ppm Cpmk Ppmk Basically total limit estimator is increased Thus 30000 000 30,00 performed 1000 1 1,00 5 10 25 3 elements Subsequently provoked 01 0 0. unit results 3000 00 30,0 100 1,0 300 30, 1,

Resumo: A análise de capacidade busca estimar a probabilidade de um processo produzir produtos em conformidade. Os índices de capacidade são parâmetros adimensionais que medem o quanto o processo consegue atender às especificações. Na literatura são listados, além de outros, oito índices da capacidade, considerando um processo estável sob controle estatístico e baseado na distribuição normal de probabilidades, definidos por: Cp, Pp, Cpk, Ppk, Cpm, Ppm, Cpmk, e Ppmk. Basicamente, as fórmulas dos índices se diferenciam nos cálculos da variabilidade dentro e total, e dos deslocamentos da média em relação ao valor nominal e ao limite de especificação mais próximo. O objetivo deste artigo foi comparar estes índices de capacidade, e para isso, buscou-se escolher o estimador mais consistente, ou seja, que melhora a acurácia e a eficiência à medida que se aumenta o número de observações. Desse modo, foi realizada uma simulação de 30.000 valores de uma variável aleatória normal com média igual a zero e desvio-padrão igual a um. Isso possibilitou amostrar este processo em 1.000 vezes utilizando-se, para isso, 5, 10, 15, 20, 25 e 30 subgrupos racionais com observações individuais ou elementos amostrais. Posteriormente, foram provocados 20 deslocamentos da média, com valores de 0,1 a 2 e variando 0,1 unidade. De acordo com os resultados, concluiu-se que os índices Cpk e Ppk foram os mais consistentes, por apresentarem maiores acurácias e eficiências para pelo menos 15 subgrupos racionais ou elementos amostrais, independentemente da magnitude do deslocamento da média em relação ao valor nominal. Resumo conformidade especificações listados outros probabilidades Cp Pp Cpm Ppm Cpmk Ppmk Basicamente total próximo isso buscouse buscou consistente seja modo 30000 000 30.00 desviopadrão desvio padrão 1000 1 1.00 utilizandose, utilizandose utilizando se, utilizando-se 5 10 3 amostrais Posteriormente 01 0 0, unidade resultados concluiuse concluiu consistentes 3000 00 30.0 100 1.0 300 30. 1.

ABSTRACT This article aims to analyze the influence of medical doctors as social actors on developing a policy for the medical workforce in Brazil. The analysis focuses on the years following 2003, when a seeking to include this policy within the scope of the National Health System took office at the Ministry of Health and met with resistance from medical societies. The study adopted sources were process tracing methodology, documents, and interviews. It is based on a neo-institutionalist theoretical approach. Findings reveal long-standing stability (1960-2002) in the policy and its institutional arrangement under the policy community formed by Liberal Medicine advocates (LM-PC); a period (2003-2009) when a thwarted attempt at change by the Ministry of Health met with the opposition of the LM-PC; a period (2010-2016) when such stability was undermined, and the policy was changed despite the opposition of the LM-PC; and, finally, a period when stability was recovered favoring the policy mentioned above community again, reversing several previous changes. However, the LM-PC could not implement its propositions since it faced opposition from other actors influencing the policy. Stability tended towards reproducing the status quo. Brazil 2003 societies methodology documents interviews neoinstitutionalist neo institutionalist approach longstanding long standing 19602002 1960 2002 (1960-2002 LMPC LM PC (LM-PC) 20032009 2009 (2003-2009 20102016 2010 2016 (2010-2016 undermined finally again changes However quo 200 1960200 196 (1960-200 (LM-PC 2003200 (2003-200 2010201 201 (2010-201 20 196020 19 (1960-20 200320 (2003-20 201020 (2010-20 2 19602 1 (1960-2 20032 (2003-2 20102 (2010-2 (1960- (2003- (2010- (1960 (2003 (2010 (196 (200 (201 (19 (20 (1 (2 (

RESUMO O artigo analisa a influência dos médicos, como ator social, na produção da Política para a Força de Trabalho em Saúde no Brasil, especialmente a partir de 2003, quando assume a direção do Ministério da Saúde (MS) um grupo interessado em fazer o Sistema Único de Saúde (SUS) ordenar essa política, mas sofre a resistência das organizações médicas. Trata-se de um estudo de caso que utilizou o process tracing como metodologia, documentos e entrevistas como fontes, e o Neoinstitucionalismo como recurso teórico. Os principais resultados são a identificação de um longo período de estabilidade na política (1960-2002), devido à atuação da Comunidade de Política Defesa da Medicina Liberal (CP-M Liberal). A análise de um período (2003-2009) no qual houve tentativa de mudança por parte da direção do MS, mas sem sucesso naquilo que sofria a oposição da CP-M Liberal; de um período no qual essa estabilidade foi rompida (2010-2016); e, por fim, de um período no qual foi restaurada a estabilidade em favor da CP-M Liberal, revertendo diversas mudanças feitas no período anterior. Porém, tampouco esta comunidade conseguiu implementar suas propostas que sofriam a oposição dos demais atores que influenciam a política. A estabilidade tendeu à reprodução do status quo. médicos social Brasil 2003 MS (MS SUS (SUS médicas Tratase Trata se metodologia fontes teórico 19602002, 19602002 1960 2002 , (1960-2002) CPM CP M Liberal. . Liberal) 20032009 2009 (2003-2009 20102016 2010 2016 (2010-2016) fim anterior Porém quo 200 1960200 196 (1960-2002 2003200 (2003-200 2010201 201 (2010-2016 20 196020 19 (1960-200 200320 (2003-20 201020 (2010-201 2 19602 1 (1960-20 20032 (2003-2 20102 (2010-20 (1960-2 (2003- (2010-2 (1960- (2003 (2010- (1960 (200 (2010 (196 (20 (201 (19 (2 (1 (

Abstract Introduction Fibromyalgia is a complex, generalized, and diffuse chronic musculoskeletal pain. Pharmacological approaches are widely used to relieve pain and increase quality of life. Low-Dose Naltrexone (LDN) was shown to increase the nociceptive threshold in patients with fibromyalgia. Transcranial Direct Current Stimulation (tDCS) is effective for pain management. Objective The purpose of this study was to evaluate the analgesic and neuromodulatory effects of a combination of LDN and tDCS in patients with fibromyalgia. Methods This was a randomized, double-blinded, parallel, placebo/sham-controlled trial (NCT04502251; RBR-7HK8N) in which 86 women with fibromyalgia were included, and written informed consent was obtained from them. The patients were allocated into four groups: LDN + tDCS (n = 21), LDN + tDCS Sham (n = 22), placebo + tDCS (n = 22), and placebo+tDCS Sham (n = 21). The LDN or placebo (p.o.) intervention lasted 26 days; in the last five sessions, tDCS was applied (sham or active, 20 min, 2 mA). The following categories were assessed: sociodemographic, Visual Analog Pain Scale (VAS), Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory (STAI), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI-II), Profile of Chronic Pain Scale (PCP:S), Pain Pressure Threshold (PPT), and Conditioned Pain Modulation (CPM). Blood samples were collected to analyze BDNF serum levels. Results At baseline, no significant difference was found regarding all measurements. VAS pain was significantly reduced in the LDN + tDCS (p = 0.010), LDN + tDCS Sham (p= 0.001), and placebo+tDCS Sham (p= 0.009) groups. In the PCP:S, the LDN+tDCS group showed reduced pain frequency and intensity (p= 0.001), effect of pain on activities (p= 0.014) and emotions (p= 0.008). Depressive symptoms reduced after all active interventions (p > 0.001). Conclusion Combined LDN+tDCS has possible benefits in reducing pain frequency and intensity; however, a placebo effect was observed in pain using VAS, and further studies should be performed to analyze the possible association. complex generalized life LowDose Low Dose (LDN (tDCS management randomized doubleblinded, doubleblinded double blinded, blinded double-blinded parallel placebo/shamcontrolled placeboshamcontrolled placebo/sham controlled sham NCT04502251 NCT (NCT04502251 RBR7HK8N RBRHKN RBR 7HK8N HK N RBR-7HK8N 8 included them groups n 21, 21 , 21) 22, 22 22) placebotDCS 21. . p.o. po p o (p.o. days sessions min mA. mA mA) assessed sociodemographic (VAS) PCS, PCS (PCS) StateTrait State Trait STAI, STAI (STAI) FIQ, FIQ (FIQ) BDIII, BDIII BDI II (BDI-II) PCPS, PCPS PCP S (PCP:S) PPT, PPT (PPT) CPM. CPM (CPM) levels baseline measurements 0.010, 0010 0.010 0 010 0.010) p= 0.001, 0001 0.001 001 0.001) 0.009 0009 009 S, PCP:S LDNtDCS 0.014 0014 014 0.008. 0008 0.008 008 0.008) 0.001. however association shamcontrolled placebosham NCT0450225 (NCT0450225 HKN p.o (p.o (VAS (PCS (STAI (FIQ (BDI-II (PCP:S (PPT (CPM 0.01 01 000 0.00 00 NCT045022 (NCT045022 0.0 NCT04502 (NCT04502 0. NCT0450 (NCT0450 NCT045 (NCT045 NCT04 (NCT04 NCT0 (NCT0 (NCT

Resumen Los productos fabricados actualmente tienen varias características de calidad, todas tienen importancia para el cliente, y controlarlas y evaluarlas se ha convertido en una actividad de primer interés. La industria automotriz establece índices de capacidad para evaluar la capacidad de los procesos donde se tiene únicamente una variable de respuesta, y cuando estos son estables se recomienda utilizar el Cp y el Cpk como medibles de la capacidad del proceso de manufactura para manufacturar productos que cumplan con las especificaciones y sean catalogados como productos de calidad. Para evaluar la calidad completa de un producto, la cual depende de que se cumpla con varias características de calidad simultáneamente, existen propuestas en la literatura de cómo medir la capacidad de procesos multivariados; la mayoría de estas coinciden en que se debe establecer claramente una región de especificación que represente lo que establece el cliente y otra región que muestre la variación como medida de desempeño del proceso. En la definición de ambas regiones existe una gran controversia entre los autores, lo que lleva a presentar esta nueva propuesta, mediante la cual se definen de manera confiable estas dos regiones mencionadas, y al hacer una comparación entre ellas se pueden obtener los índices de capacidad multivariados Cpm y el Cpkm y el como una extensión de los índices univariados Cp y el Cpk. El documento incluye el análisis de datos de un proceso donde el producto, para ser de buena calidad, debe cumplir con dos características de calidad simultáneamente. Las mediciones obtenidas del proceso se pueden representar por una distribución normal multivariada, lo que permite medir la capacidad del proceso utilizando los índices propuestos y realizar una interpretación de estos en relación con el desempeño del proceso.

Abstract Currently manufactured products have several quality characteristics, all of which are important to the customer, and controlling and evaluating them has become an activity of prime interest. The automotive industry establishes capacity indices to evaluate the capacity of processes where there is only one response variable, and when these are stable, it recommends using Cp and Cpk as measures of the capacity of the manufacturing process to manufacture products that comply with specifications and are cataloged as quality products. To evaluate the complete quality of a product, which depends on meeting several quality characteristics simultaneously, there are proposals in the literature on how to measure the capability of multivariate processes; most of these agree that a specification region should be clearly established to represent the customer's requirements and another region to show the variation as a measure of process performance. In the definition of both regions there is a great controversy among the authors, which leads to present this new proposal, by which these two regions are defined in a reliable way, and by making a comparison between them, the multivariate capacity indexes Cpm and Cpkm can be obtained as an extension of the univariate indexes Cp and Cpk. The document includes the data analysis of a process where the product to be of good quality must meet two quality characteristics simultaneously. The measurements obtained from the process can be represented by a multivariate normal distribution, which allows measuring the process capability using the proposed indexes and interpreting them in relation to the process performance.

Resumo Os produtos fabricados atualmente possuem diversas características de qualidade, todas importantes para o cliente, e controlá-los e avaliá-los tornou-se uma atividade de grande interesse. A indústria automotiva estabelece índices de capacidade para avaliar a capacidade de processos onde há apenas uma variável de resposta, e quando estes estão estáveis, recomenda o uso de Cp e Cpk como medidas da capacidade do processo de fabricação em fabricar produtos que atendam às especificações e sejam catalogados como produtos de qualidade. Para avaliar a qualidade completa de um produto, que depende do cumprimento de várias características de qualidade simultaneamente, existem propostas na literatura sobre como medir a capacidade de processos multivariados; a maioria concorda que uma definição clara deve ser estabelecida. que representa o que o cliente estabelece e outra região que mostra a variação como medida de desempenho do processo. Na definição de ambas as regiões há grande controvérsia entre os autores, o que leva a apresentar esta nova proposta, pela qual estas duas regiões são definidas de forma fiável, e fazendo uma comparação entre elas é possível obter os índices de capacidade multivariados Cpm e Cpkm como uma extensão dos índices univariados Cp e Cpk. O documento inclui a análise de dados de um processo onde o produto para ser de boa qualidade deve atender a duas características de qualidade simultaneamente. As medições obtidas a partir do processo podem ser representadas por uma distribuição normal multivariada, permitindo que a capacidade do processo seja medida utilizando os índices propostos e uma interpretação destes índices em relação ao desempenho do processo.

Resumo Objetivo O objetivo deste estudo foi avaliar o perfil nociceptivo e o uso de analgésicos em pacientes submetidos à cirurgia de reparo do manguito rotador. Além disso, os limiares nociceptivos e a integridade do sistema inibidor descendente, o catastrofismo da dor e a prevalência de dor nociceptiva ou neuropática também foram analisados. Métodos Este estudo foi aprovado pelo Comitê de Ética da Universidade La Salle (1.325.433/2015). Quarenta pacientes (maiores de 18 anos) submetidos à cirurgia de reparo do manguito rotador (divididos entre aqueles com lesões pequenas e grandes) participaram do estudo. Os instrumentos utilizados foram o Questionário Sociodemográfico, a Escala Funcional de Dor, a Escala Visual Análoga (EVA), o Teste Sensorial Quantitativo (QST) e a Tarefa de Modulação Condicionada da Dor (CPM). Resultados Os pacientes apresentaram diferenças significativas nos limiares de dor e QST de calor (teste t de amostras independentes) e qualidade do sono, humor e ansiedade (teste t pareado) nos grupos pré-operatórios. Houve uma correlação significativa entre CPM pré-operatória e EVA pós-operatória (correlação de Pearson). Observou-se que, no período pré-operatório, 38 pacientes utilizavam analgésico de forma contínua. Além disso, no período pós-operatório, o uso de opioides foi maior nos pacientes com lesões pequenas (13 pacientes) em comparação àqueles com lesões grandes (nove pacientes). Conclusão Os pacientes com lesão do manguito rotador não apresentaram alterações no sistema inibidor descendente, mas sim alterações nos limiares de dor, o que pode interferir no período pós-operatório e estar relacionado ao consumo de analgésicos.

Abstract Objective This study aimed to evaluate the nociceptive profile and the intake of analgesic drugs of patients submitted to rotator cuff repair surgery. Also, to evaluate the nociceptive thresholds and the integrity of the descending inhibitory system, pain catastrophism and prevalence of nociceptive or neuropathic pain. Methods Approved by the Ethics Committee of La Salle University (1.325.433/2015). 40 patients (>18 years old) who underwent rotator cuff repair surgery (divided in small and large injuries) were recruited. The used instruments were: Sociodemographic Questionnaire, Functional Pain Scale, Visual Analogue Scale (VAS), Quantitative Sensory Test (QST) and Conditioned Pain Modulation Task (CPM). Results Patients had a significant difference in pain thresholds QST heat (independent samples t test) and quality of sleep, mood and anxiety (paired t test) in groups preoperative. There was a significant correlation between preoperative CPM and postoperative VAS (Pearson Correlation). It was observed that, in preoperative, 38 patients used analgesics continuously. Besides that, in postoperative, use of opioid drugs was higher in patients with small injury (13 patients) than in those with large injury (9 patients). Conclusion Therefore, patients with rotator cuff injuries did not present alterations in the descending inhibitory system, but showed alterations in pain thresholds, which may interfere in the postoperative period and still be related to the consumption of analgesics.

SUMMARY The aims of this work were to monitor the dissipation dynamics of the organophosphate insecticides applied to corn grains stored in supervised experiments, establish the dissipation dynamics and determine the minimum period post application necessary to comply with the established commercial standards. The insecticides dichlorvos (DDVP), chlorpyrifos-methyl+deltamethrin (CPM) and pirimiphos-methyl (PMM) were applied to maize grains, which were then stored for 120 days. The samples were processed and extracted using the QuEChERS technique and the pesticide residues were ¡dentified and quantified by gas chromatography-mass spectrometry. Deltamethrin residues were not analized. After 90 days of storage, more than 80 % of the initial residue had been degraded, and after 120 days the residues were below the detection limit (LoD). DDVP, CPM and PMM residues followed a first order degradation dynamics [Ct=C0xe(-kt)], with k values of 0.384, 0.025 and 0.020 and estimated half-lives of 1.8, 27.7 and 34.7 days, respectively. These results show that at recommended dosages, the insecticides CPM and PMM are safe for use on stored maize grains; DDVP results provide additional evidence further reasserting its prohibition, which dates back to 2018.

RESUMEN Los objetivos del trabajo fueron monitorear la degradación de insecticidas organofosforados aplicados a granos de maíz almacenados en ensayos experimentales, establecer las dinámicas de degradación y determinar el tiempo mínimo de espera post aplicación necesario para cumplir con los estándares comerciales. Se aplicaron los insecticidas diclorvós (DDVP), clorpirifós-metil+deltametrina (CPM) y pirimifós-metil (PMM) a granos de maíz almacenados durante 120 días. Las muestras se procesaron y extrajeron mediante la técnica QuEChERS y los residuos de plaguicidas se identificaron y cualificaron mediante cromatografía de gases-espectrometría de masas. Los residuos de deltametrina no fueron determinados. Luego de 90 días de almacenamiento, más del 80 % del contenido inicial de residuos se había degradado y a los 120 días se encontraban por debajo del límite de detección (LoD). Los residuos de DDVP CPM y PMM siguieron una dinámica de degradación de primer orden [Ct=C0xe(-kt)], con valores de k de 0,384, 0,025 y 0,020 y vidas medias estimadas de 1;8; 27,7 y 34,7 días respectivamente. Estos resultados permiten concluir que a la dosis recomendada, los insecticidas CPM y PMM se pueden usar de manera segura en granos de maíz almacenados, mientras que los resultados de DDVP aportan información adicional que ratifica su prohibición, que data del año 2018.