RESUMO Objetivo: Avaliar a sazonalidade da bronquiolite aguda no Brasil durante a temporada 2020–2022 e compará-la com a das temporadas anteriores. Métodos: Os dados de incidência de internações por bronquiolite aguda em lactentes <1 ano de idade foram obtidos do Departamento de Informática da base de dados da Saúde Pública Brasileira para o período entre 2016 e 2022. Esses dados também foram analisados por macrorregiões do Brasil (Norte, Nordeste, Sudeste, Sul e Centro-Oeste). Para descrever características sazonais e de tendência ao longo do tempo, utilizamos o Modelo de Médias Móveis Integradas Autorregressivas Sazonais. Resultados: Em comparação com o período pré-COVID-19, a incidência de hospitalizações relacionadas com bronquiolite aguda diminuiu 97% durante as intervenções não farmacológicas (março de 2020 – agosto de 2021), mas aumentou 95% após a flexibilização das intervenções não farmacológicas (setembro de 2021 – dezembro de 2022), resultando no aumento geral de 16%. Durante o período pré-COVID-19, as hospitalizações por bronquiolite aguda seguiram um padrão sazonal, que foi interrompido em 2020–2021, mas recuperaram-se em 2022, com um pico ocorrido em maio, aproximadamente 4% superior ao pico pré-COVID-19. Conclusões: Este estudo ressalta a influência significativa das intervenções contra a COVID-19 nas hospitalizações por bronquiolite aguda no Brasil. A restauração de um padrão sazonal em 2022 sublinha a interação entre as medidas de saúde pública e a dinâmica das doenças respiratórias em crianças pequenas. Objetivo 20202022 2020–202 comparála compará la anteriores Métodos 1 < 201 Norte, Norte (Norte Nordeste Sudeste CentroOeste. CentroOeste Centro Oeste . Centro-Oeste) tempo Sazonais Resultados préCOVID19, préCOVID19 préCOVID pré COVID 19, 19 pré-COVID-19 97 março 202 2021, , 2021) 95 setembro 2022) 16 16% 20202021 2020–2021 recuperaramse recuperaram se maio 4 préCOVID19. 19. Conclusões COVID19 COVID-1 pequenas 2020202 2020–20 20 Centro-Oeste préCOVID1 pré-COVID-1 9 COVID1 COVID- 202020 2020–2 2 pré-COVID- 20202 2020– pré-COVID

ABSTRACT Objective: To evaluate the seasonality of acute bronchiolitis in Brazil during the 2020–2022 season and compare it with the previous seasons. Methods: Data from the incidence of hospitalizations due to acute bronchiolitis in infants <1 year of age were obtained from the Department of Informatics of the Brazilian Public Health database for the period between 2016 and 2022. These data were also analyzed by macro-regions of Brazil (North, Northeast, Southeast, South, and Midwest). To describe seasonal and trend characteristics over time, we used the Seasonal Autoregressive Integrated Moving Averages Model. Results: Compared to the pre-COVID-19 period, the incidence of hospitalizations related to acute bronchiolitis decreased by 97% during non-pharmacological interventions (March 2020 – August 2021) but increased by 95% after non-pharmacological interventions relaxation (September 2021 – December 2022), resulting in a 16% overall increase. During the pre-COVID-19 period, hospitalizations for acute bronchiolitis followed a seasonal pattern, which was disrupted in 2020–2021 but recovered in 2022, with a peak occurring in May, approximately 4% higher than the pre-COVID-19 peak. Conclusions: This study underscores the significant influence of COVID-19 interventions on acute bronchiolitis hospitalizations in Brazil. The restoration of a seasonal pattern in 2022 highlights the interplay between public health measures and respiratory illness dynamics in young children. Objective 20202022 2020–202 seasons Methods 1 < 201 macroregions macro regions North, North (North Northeast Southeast South Midwest. Midwest . Midwest) time Model Results preCOVID19 preCOVID pre COVID 19 pre-COVID-1 97 nonpharmacological non pharmacological March 202 95 September , 2022) 16 increase 20202021 May 4 Conclusions COVID19 COVID-1 children 2020202 2020–20 20 preCOVID1 pre-COVID- 9 COVID1 COVID- 202020 2020–2 2 pre-COVID 20202 2020–

The in silico study aimed to suggest phytochemicals from Commiphora leptophloeos leaves essential oil as therapies against coronavirus disease (COVID-19) (or severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). For that, we used molecular docking (MD), absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters, and pharmacokinetic analysis. MD showed the presence of hydrophobic and hydrogen bonds for nine compounds. β-Selinene and bicyclogermacrene showed the best interaction values with the protein Mpro (ID: 6Y2F) (-5.9) and chimeric receptor complexed with its receptor human ACE2 (ID: 6VW1) (-6.1 and -5.5) proteins, as well as low gastrointestinal and high epithelial absorptions, medium permeability for Caco-2 cells and high epithelial permeability, low oral excretion, and were inhibitors of CYP2C19 and CYP2C9 enzymes. On the other hand, both were not permeable to the blood-brain barrier and inhibitors or substrates for glycoprotein-D, and showed carcinogenic potential, but only β-selinene was considered mutagenic. Although little bioavailable, both presented aspects structurally adequate, being compounds with moderate synthesis difficulty. Therefore, more analyses are necessary to evaluate the mechanism of action and unsatisfactory parameters foreseen in bioinformatic assays. COVID19 COVID 19 (COVID-19 2 SARSCoV2. SARSCoV2 SARSCoV SARS CoV . SARS-CoV-2) that MD, , (MD) absorption distribution metabolism excretion ADMET (ADMET analysis βSelinene β Selinene ID (ID 6Y2F YF Y F 5.9 59 5 9 (-5.9 ACE 6VW1 VW 6.1 61 6 1 (-6. 5.5 55 -5.5 proteins absorptions Caco2 Caco Caco- CYPC CYP C CYP2C1 CYP2C enzymes hand bloodbrain blood brain glycoproteinD, glycoproteinD glycoprotein D, D glycoprotein-D potential βselinene selinene mutagenic bioavailable adequate difficulty Therefore assays COVID1 (COVID-1 SARS-CoV-2 (MD 5. (-5. 6VW 6. (-6 -5. (COVID- SARS-CoV- (-5 (- -5 (COVID SARS-CoV ( -

RESUMO Objetivo: Comparar a presença de anticorpos neutralizantes contra o SARS-CoV-2 no leite materno e no sangue das lactantes vacinadas em relação àquelas não vacinadas. Fontes de dados: Foi efetuado registro no International Prospective Register of Systematic Reviews — PROSPERO (CRD42021287554) e foram seguidas as diretrizes do Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Foram elegíveis estudos de coorte, caso-controle e transversais que avaliaram anticorpos contra o SARS-CoV-2 no leite e no sangue de lactantes vacinadas e tiveram como grupo controle lactantes não vacinadas. Utilizaram-se os Descritores em Ciências da Saúde (DeCs), Medical Subject Heading (MeSH) e Emtree para as bases Biblioteca Virtual em Saúde (BVS), Medical Literature Analysis and Retrieval System Online (Medline/PubMed) e Embase, respectivamente. Na Web of Science e Scopus foi feita adaptação da estratégia. Não foram estabelecid as restrições quanto ao período de publicação e idioma. Síntese dos dados: As buscas identificaram 233 registros. Foram excluídos 128 duplicados e 101 fora dos critérios de inclusão, e quatro estudos de coorte foram elegíveis. As lactantes vacinadas com Pfizer-BioNTech e Moderna apresentaram anticorpos contra SARS-CoV-2 no sangue e no leite materno. Conclusões: As mulheres lactantes vacinadas apresentaram níveis mais elevados de imunoglobulina G (IgG) e A (IgA) no soro e no leite materno em comparação com as mulheres não vacinadas. Objetivo SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- dados CRD42021287554 CRD (CRD42021287554 MetaAnalysis Meta PRISMA. PRISMA . (PRISMA) casocontrole caso Utilizaramse Utilizaram se DeCs, DeCs , (DeCs) MeSH (MeSH BVS, BVS (BVS) Medline/PubMed MedlinePubMed Medline PubMed (Medline/PubMed Embase respectivamente estratégia idioma 23 registros 12 10 inclusão PfizerBioNTech Pfizer BioNTech Conclusões IgG (IgG IgA (IgA SARS-CoV CRD4202128755 (CRD4202128755 (PRISMA (DeCs (BVS 1 CRD420212875 (CRD420212875 CRD42021287 (CRD42021287 CRD4202128 (CRD4202128 CRD420212 (CRD420212 CRD42021 (CRD42021 CRD4202 (CRD4202 CRD420 (CRD420 CRD42 (CRD42 CRD4 (CRD4 (CRD

ABSTRACT Objective: To compare the presence of neutralizing antibodies against SARS-CoV-2 found in the breast milk and blood of vaccinated lactating women with those not vaccinated. Data source: The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under CRD42021287554 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cohort, case-control, and cross-sectional studies that evaluated antibodies against SARS-CoV-2 in the milk and blood of vaccinated mothers and had as control group unvaccinated mothers were eligible. Health Sciences Descriptors (DeCs), Medical Subject Headings (MeSH) and Emtree descriptors were used for the Virtual Health Library (VHL), Medical Literature Analysis and Retrieval System Online (Medline/Pubmed), and Embase databases, respectively. In the Web of Science and Scopus, the strategy was adapted. No restrictions on the publication period and language were set. Data synthesis: The search identified 233 records, of which 128 duplicates and 101 papers that did not meet the inclusion criteria were excluded. Hence, four cohort studies were eligible. Nursing mothers vaccinated with the Pfizer-BioNTech and Moderna vaccines showed antibodies against SARS-CoV-2 in their blood and breast milk. Conclusions: Vaccinated lactating women had higher levels of immunoglobulin G (IgG) and A (IgA) in serum and breast milk than unvaccinated women. Objective SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- source PROSPERO (PROSPERO CRD CRD4202128755 MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines Cohort casecontrol, casecontrol case control, case-control crosssectional cross sectional eligible DeCs, DeCs , (DeCs) MeSH (MeSH VHL, VHL (VHL) Medline/Pubmed, MedlinePubmed Medline/Pubmed Medline Pubmed (Medline/Pubmed) databases respectively Scopus adapted set synthesis 23 records 12 10 excluded Hence PfizerBioNTech Pfizer BioNTech Conclusions IgG (IgG IgA (IgA SARS-CoV CRD420212875 (DeCs (VHL (Medline/Pubmed 1 CRD42021287 CRD4202128 CRD420212 CRD42021 CRD4202 CRD420 CRD42 CRD4

Resumen Marco contextual: La pandemia de SARS- CoV-2 ha planteado numerosos retos a las madres de niños y jóvenes de hasta 18 años, debido a la gestión de las responsabilidades inherentes a su papel social. Objetivo: Comprender los significados y contextos de las experiencias de las madres portuguesas de niños y jóvenes adolescentes de hasta 18 años, durante la situación de pandemia de COVID-19. Metodología: Estudio cualitativo, descriptivo y retrospectivo mediante el análisis de contenido de Bardin. Participaron en el estudio 16 mujeres, madres de niños y jóvenes adolescentes de hasta 18 años. Resultados: Surgieron un total de nueve categorías - Sentimientos; Percepción de la salud; Cambios en el estado de salud; Experiencias notables; Significado de las experiencias; Dificultades sentidas durante la situación de pandemia; Dificultades sentidas en la educación; Dificultades sentidas como madre y esposa, e Impactos en la educación de los hijos. Conclusión: La mayoría de las madres entrevistadas consideraron que el periodo de la pandemia de COVID-19 fue una fase impactante en sus vidas, lo que dio lugar a una ambivalencia de sentimientos y diferentes contextos experienciales.

Abstract Background: The COVID-19 pandemic has posed many challenges for mothers of children and adolescents up to 18 years of age in managing the responsibilities associated with their social roles. Objective: To understand the meanings and contexts of the experiences of Portuguese mothers of children and adolescents up to 18 years of age during the COVID-19 pandemic. Methodology: Qualitative, descriptive, and retrospective study using Bardin’s content analysis. The sample consisted of 16 mothers of children and adolescents up to 18 years of age. Results: Nine categories emerged - Feelings; Perception of health; Changes in health status; Significant experiences; Meaning of experiences; Difficulties felt during the pandemic; Difficulties felt in education; Difficulties felt as a mother and wife; and Impact on children’s education. Conclusion: Most of the interviewed mothers considered the COVID-19 pandemic a significant period in their lives, giving rise to ambivalent feelings and distinct life contexts.

Resumo Enquadramento: A pandemia por COVID-19 trouxe inúmeros desafios às mães de crianças e jovens até aos 18 anos de idade, pela gestão de responsabilidades a que o seu papel social se encontra inerente. Objetivo: Compreender quais são os significados e os contextos das vivências de mães portuguesas de crianças e jovens adolescentes até aos 18 anos de idade, no período de situação pandémica por COVID-19; Metodologia: Estudo qualitativo, descritivo e retrospetivo recorrendo à análise de conteúdo de Bardin. Participaram no estudo 16 mulheres, mães de crianças e jovens adolescentes até aos 18 anos de idade. Resultados: Emergiram um total de nove categorias, sendo elas - Sentimentos; Perceção de saúde; Alterações no estado de saúde; experiências marcantes; Significado das experiências; Dificuldades sentidas durante o período de situação pandémica; dificuldades sentidas na educação; dificuldades sentidas enquanto mãe e mulher e impactos na educação dos filhos. Conclusão: A maioria das mães entrevistadas considerou o período pandémico por COVID-19 como uma fase impactante nas suas vidas, originando ambivalência de sentimentos e contextos vivenciais distintos.

Resumen Marco contextual: En tiempos de pandemia, las citas de enfermería para el seguimiento del embarazo cambiaron, sobre todo la restricción de acompañantes. Por esta razón, es importante evaluar la satisfacción de las mujeres embarazadas con los cuidados de enfermería durante este contexto pandémico. Objetivo: Evaluar la satisfacción de las mujeres embarazadas con la atención prestada por las enfermeras obstétricas en las consultas de seguimiento del embarazo durante la pandemia de COVID-19. Metodología: Estudio descriptivo transversal de carácter cuantitativo, con una muestra de 196 mujeres embarazadas. Se aplicó la Escala de Satisfacción de los Pacientes con Asistencia de Enfermería (General Practice Nurse Satisfaction Scale - GPNS), compuesta por las siguientes dimensiones: relaciones interpersonales y comunicación, confianza, credibilidad y dedicación. Resultados: Las mujeres embarazadas están, de media, más satisfechas en la dimensión relaciones interpersonales y comunicación, y menos satisfechas en la dimensión dedicación. Conclusión: Las embarazadas se mostraron satisfechas con los cuidados de enfermería y se dieron cuenta de su importancia. Esto refuerza la pertinencia de que las consultas sean realizadas por una enfermera especializada en Enfermería de Salud Materna y Obstétrica.

Abstract Background: Prenatal nursing appointments underwent changes during the COVID-19 pandemic, namely in the restriction of companions. For this reason, it is important to assess pregnant women’s satisfaction with nursing care during this period. Objective: To assess pregnant women’s satisfaction with nurse midwife-led prenatal appointments during the COVID-19 pandemic. Methodology: A qualitative descriptive cross-sectional study was conducted with a sample of 196 pregnant women. The Portuguese version of the General Practice Nurse Satisfaction Scale (Escala de Satisfação dos Pacientes com a Assistência de Enfermagem) was administered to the sample. The tool consists of the following dimensions: interpersonal relationship and communication, confidence, credibility, and dedication. Results: Pregnant women are, on average, more satisfied in the interpersonal relationship and communication dimension and less satisfied in the dedication dimension. Conclusion: Pregnant women are satisfied with nursing care and acknowledge its importance. This finding reinforces the importance of nurse midwife-led consultations.

Resumo Enquadramento: Em tempo de pandemia, as consultas de enfermagem de vigilância da gravidez sofreram alterações, nomeadamente na restrição de acompanhantes. Por esse motivo, é importante a avaliação da satisfação das grávidas com a assistência de enfermagem durante este contexto pandémico. Objetivo: Avaliar a satisfação da grávida com a assistência das enfermeiras obstétricas nas consultas de vigilância da gravidez durante o contexto de pandemia COVID-19. Metodologia: Estudo transversal descritivo de natureza quantitativa, com uma amostra de 196 grávidas. Aplicado a Escala de Satisfação dos Pacientes com a Assistência de Enfermagem (General Practice Nurse Satisfaction Scale - GPNS), constituída pelas dimensões: relacionamento interpessoal e comunicação, confiança, credibilidade e dedicação. Resultados: As grávidas apresentam-se em média mais satisfeitas na dimensão relacionamento interpessoal e comunicação e menos satisfeitas na dimensão dedicação. Conclusão: As grávidas apresentam-se satisfeitas com a assistência de enfermagem percecionando a sua importância. Tal reforça a pertinência das consultas serem realizadas por um Enfermeiro Especialista em Enfermagem de Saúde Materna e Obstétrica.

Resumen: La pandemia por COVID-19 influyó en el proceso de educación superior generando una transición entre la modalidad presencial a la modalidad en línea-emergente en la que se identificaron varias dificultades para el acceso debido a la inequidad, problemas tecnológicos, crisis de salud y económica a nivel mundial, y en Ecuador a nivel de docentes y estudiantes. El descubrimiento de conocimiento en bases de datos de KDD - Educacional, el análisis de técnicas de minería de datos de clasificación y agrupación, y el complemento de análisis de datos con la inteligencia de negocios determinaron los factores desde la perspectiva de la institución, del docente y de los estudiantes que inciden en el proceso de educación en línea, donde se demuestra además, la importancia del modelo de educación, la metodología del proceso de enseñanza aprendizaje, el entorno de aprendizaje y el bienestar de los docentes y estudiantes que garantizan una educación superior en línea de calidad con igualdad de oportunidades en el acceso.

Abstract: The COVID-19 pandemic significantly impacted higher education, forcing a rapid transition from face-to-face modality to the emerging online learning modality. This transition exposed several challenges, including, inequitable access to technology, global health and economic crisis, and specific difficulties faced by both teachers and students in Ecuador. Knowledge discovery in KDD - Educational databases, the analysis of classification and clustering data mining techniques and the complement of data analysis with business intelligence determined the factors from the perspective of the institution, teachers and students that influence the online education process. In addition, the importance of the education model, the teaching-learning process methodology, the learning environment, and the well-being of teachers and students that guarantee quality online higher education with equal access opportunities is demonstrated.

Abstract The present study aims to identify the impact generated by the information media, social networks and the media on Peruvian university students in the context of the COVID19 quarantine in Peru, and to know how it relates to the emotional state, and to the compliance with health recommendations. This retrospective correlational study collected information from 396 students from a Peruvian university, Universidad Nacional Mayor de San Marcos, through a virtual survey conducted during two weeks of the Peruvian quarantine (March 13 - May 13, 2021). The main results show that there is an association between the effects of the media and compliance with health recommendations. The most reassuring messages came from authorities such as the president of Peru, the university, and government text messages; as well as television; while the most disturbing messages were spread through social networks and other media. Furthermore, the findings show that university students mostly complied with the main recommendations of the Peruvian government and the WHO.

Resumen El presente estudio tiene como objetivo identificar el impacto que generan los medios de información, las redes sociales y los medios de comunicación en los estudiantes universitarios peruanos en el contexto de la cuarentena de COVID19 en Perú, y conocer cómo se relaciona con el estado emocional y el cumplimiento de las recomendaciones de salud. Este estudio correlacional retrospectivo recopiló información de 396 estudiantes de una universidad peruana, la Universidad Nacional Mayor de San Marcos, a través de una encuesta virtual realizada durante dos semanas de la cuarentena peruana (del 13 de marzo al 13 de mayo del 2021). Los principales resultados muestran que existe una asociación entre los efectos de los medios y el cumplimiento de las recomendaciones sanitarias. Los mensajes más tranquilizadores vinieron de autoridades como el presidente del Perú, la universidad y los mensajes de texto del gobierno; así como de la televisión; mientras que los mensajes más inquietantes se difundieron a través de las redes sociales y los otros medios de comunicación. Además, los hallazgos muestran que los estudiantes universitarios cumplieron mayormente con las recomendaciones principales del gobierno peruano y de la OMS.

RESUMEN Introducción: el SARS-CoV-2 desde el 2020 generó innumerables desafíos. El decúbito prono se utilizó para mejorar la oxigenación, y la terapia nutricional se adaptó para cubrir los requerimientos y reducir complicaciones. Objetivos: evaluar la tolerancia de la nutrición enteral y su adecuación energética en pacientes ventilados en decúbito prono con infección por SARS-CoV-2, en sala respiratoria del Departamento de Cuidados Intensivos Adultos del Hospital de Clínicas-Facultad de Ciencias Médicas - Universidad Nacional de Asunción, de marzo a julio 2021. Metodología: estudio observacional, descriptivo, retrospectivo, de corte transversal, de casos consecutivos, con información obtenida de fichas de pacientes de terapia intensiva, que recibieron soporte nutricional en posición prona. Se tomaron datos demográficos, clínicos y nutricionales. Se evaluó la tolerancia nutricional durante la posición prona, definiéndola como la presencia de un volumen de residuo gástrico < 500 mL cada 6 h.. La adecuación energética fue determinada teniendo en cuenta el porcentaje cumplido de la prescripción nutricional. Resultados: se reclutaron 41 pacientes. El 60,9 % eran hombres; la mediana de edad fue 55 años (RIC=23). Las principales comorbilidades fueron obesidad (57,3 %) e hipertensión arterial (43,9 %). El 85,4 % presentó buena tolerancia gástrica en posición prono, con residuo gástrico menor a 500 ml. El porcentaje de adecuación energética fue de 84 %. Conclusión: la terapia nutricional enteral en decúbito prono fue bien tolerada por la mayoría de nuestros pacientes, posibilitando alcanzar los requerimientos nutricionales indicados.

ABSTRACT Introduction: SARS-CoV-2 since 2020 has generated countless challenges. Prone position was used to improve oxygenation, and nutritional therapy was adapted to meet requirements and reduce complications. Objectives: evaluate the tolerance of enteral nutrition and its energetic adequacy in ventilated patients in the prone position with SARS-CoV-2 infection, in the respiratory room of the Adult Intensive Care Department of the Hospital de Clínicas - Facultad de Ciencias Médicas - Universidad Nacional de Asunción, from March to July 2021. Methodology: observational, descriptive, retrospective, cross-sectional study of consecutive cases, with information obtained from records of intensive care patients, who received nutritional support in a prone position. Demographic, clinical and nutritional data were taken. Nutritional tolerance was evaluated during the prone position, defining it as the presence of a volume of gastric residue < 500 mL every 6 h. Energy adequacy was determined taking into account the percentage fulfilled of the nutritional prescription. Results: 41 patients were recruited. 60.9 % were men; the median age was 55 years (IQR=23). The main comorbidities were obesity (57.3 %) and high blood pressure (43.9 %). 85.4 % had good gastric tolerance in the prone position, with gastric residue less than 500 ml. The percentage of energy adequacy was 84 %. Conclusion: enteral nutritional therapy in the prone position was well tolerated by the majority of our patients, making it possible to achieve the indicated nutritional requirements.

Abstract As a result of COVID-19, new dynamics emerged in many urban systems, including the acquisition and distribution of food. The pandemic revealed vulnerabilities in the functioning of facilities and intensified problems such as informality, insecurity, and immigration. In order to contribute to the identification and characterization of these dynamics within food markets, a case study methodology was adopted for this article using mixed techniques - a quantitative approach using a survey and a qualitative approach featuring a focus group. Both methods were applied in the San Roque market in the Metropolitan District of Quito, an iconic food market and distribution facility. The results highlight new commercial dynamics and preferences, as in recent years informal trade and the presence of supermarket chains have proliferated; new logistic means have been created; and wholesale trade has intensified. In addition, the pandemic accentuated the vulnerability of the market at the administrative level and the precariousness of some informal jobs, in turn, accelerated changes among traders. It is concluded that these dynamics merit new conceptual, organizational, and spatial approaches in architectural and urban terms, as well as different policies that favor the sustainable management of markets.

Resumen A raíz de la covid-19 se dieron nuevas dinámicas en muchos sistemas urbanos entre las que destaca la de adquisición y distribución de alimentos. La pandemia mostró la vulnerabilidad en el funcionamiento de equipamientos e intensificó problemáticas como la informalidad, la inseguridad y la inmigración. Con el objetivo de aportar a la identificación y caracterización de estas dinámicas dentro de los mercados de alimentos, para el presente artículo se adoptó una metodología de caso de estudio con técnicas mixtas: cuantitativas por medio de una encuesta y cualitativas a partir de un grupo focal. Ambas técnicas se aplicaron en el mercado San Roque en el Distrito Metropolitano de Quito, equipamiento icónico en cuanto a la comercialización y distribución de alimentos. En los resultados sobresalen las nuevas dinámicas y preferencias comerciales, ya que en los últimos años han proliferado el comercio informal y la presencia de cadenas de supermercados, se han creado nuevos medios logísticos y se ha intensificado el comercio mayorista. Además, la pandemia acentuó la vulnerabilidad del mercado a nivel administrativo y la precarización de algunos trabajos informales, a su vez, aceleró un cambio entre el grupo de comerciantes. Se concluye que estas dinámicas ameritan nuevas aproximaciones conceptuales, organizativas y espaciales a escala arquitectónica y urbana, y también distintas políticas que favorezcan la gestión sostenible de los mercados.

Effective pandemic decision-making depends on scientific expert evidence, transparency about public health policy decision-making, its rationales and the evidence on which it is based. The South African government laudably committed its COVID-19 response to be guided by science and evidence. Yet, the expert advice that it received was not always readily made available to the public. This submission analyses the time elapsed between the submission of COVID-19 Ministerial Advisory Committees memoranda to the Minister of Health, and the Department of Health's subsequent publication of these for the period August 2020 - January 2024. It also summarises the outcomes of the Health Justice Initiative's access to information legal action against the department on expert advice and government decision-making during the pandemic.

BACKGROUND. South Africa (SA) has committed to eliminating malaria by 2028. However, the initial target was set for 2023. Additionally, the ongoing COVID-19 pandemic and the emergence of drug and insecticide resistance have been identified as potential stumbling blocks in the achievement of this goal. The impact of COVID-19 on the prevalence and distribution of malaria in SA is unclear. OBJECTIVE. To describe the trends and distribution of malaria before and during the pandemic and its associated lockdown strategies in one of the country's malaria-endemic provinces, Mpumalanga Province. METHOD. A descriptive, retrospective and cross-sectional study was conducted using Mpumalanga provincial malaria case data extracted from the provincial District Health Information System 2. The impact of COVID-19 on the prevalence and distribution of malaria was assessed in Mpumalanga Province between 2017 and 2022 using descriptive trend analysis. Malaria cases before (2017 - 2019) and post-COVID-19 (2020 - 2022) were cross-tabulated using Stata version 17. We used χ² tests to test for significant differences, set at p<0.05. RESULTS. During the study period, 25 380 malaria cases were reported, with the majority men (61%) >26 years old, with reported international travel, primarily to Mozambique. Limpopo Province (93%) accounted for most of the locally imported cases. Headaches and fever were the most common symptoms before and post COVID-19, while asymptomatic malaria carriage was higher during and post COVID (p<0.05). Prior to the pandemic reporting of the preferred treatment for uncomplicated malaria, Coartem use was at 53%, declining to 21% thereafter. Although COVID-19-related restrictions on human movement greatly reduced the malaria burden in Mpumalanga Province, the high-risk group (young mobile men) remained unchanged over the study period. Of concern were the marked reduction in the reporting of Coartem doses administered and the increased prevalence of asymptomatic carriage since 2020. The importation of malaria poses one of the biggest challenges to malaria elimination in Mpumalanga Province. CONCLUSION. This study highlighted the impact of COVID-19 and its related lockdown restrictions on the delivery of malaria health services in Mpumalanga Province. If malaria elimination is to be achieved, all aspects of the malaria programme must be strengthened urgently. Additionally, the health system and cross-border collaborations must also be strengthened.

ABSTRACT The aim of this study was to determine the differences in perceptions of learning in virtual and in-person modalities experienced during and after the COVID-19 pandemic in a group of pre-service teachers at the National University of the Altiplano (Puno - Peru). The method used was the hypothetical-deductive approach, of a descriptive nature, with an intrinsic comparative design, and data collection was conducted cross-sectionally. The sample consisted of 116 students from the fifth to the tenth semester during the academic period of 2022-II. A validated instrument with an internal consistency of 0.978 on the Cronbach's alpha was employed. Data processing was carried out using descriptive statistics and Student's t-tests to determine significant differences. The results reveal the presence of significant differences in the perception of learning between virtual and in-person modalities, with an average score of 3.20 and 2.88, respectively, on a scale of 1 to 4. In conclusion, these findings imply that, at least during the academic period of 2022-II at this institution, students experienced more effective and satisfying learning in the in-person modality. This could be attributed to several factors, such as direct interaction with teachers and peers, access to physical resources on the university campus, and greater structure in in-person classes.

RESUMEN El objetivo fue determinar las diferencias sobre las percepciones del aprendizaje en la modalidad virtual y presencial experimentadas durante y después de la pandemia por COVID-19 en un grupo de profesores en formación de la Universidad Nacional del Altiplano (Puno - Perú). El método empleado fue el hipotético deductivo, de tipo descriptivo, de diseño comparativo intrínseco y su forma de obtención de datos fue la transversal. La muestra estuvo conformada por 116 estudiantes del quinto al décimo ciclo correspondientes al periodo académico de 2022-II. Se empleó un instrumento validado con una consistencia interna de 0.978 en el alfa de Cronbach. El procesamiento de datos se realizó mediante pruebas de estadística descriptiva y pruebas t de Student para determinar si existen diferencias significativas. Los resultados indican la presencia de diferencias significativas en la percepción del aprendizaje entre las modalidades virtual y presencial, con una puntuación media de 3.20 y 2.88, respectivamente, en una escala del 1 al 4. En conclusión, estos hallazgos sugieren que, al menos durante el periodo académico de 2022-II en esta institución, los estudiantes experimentaron un aprendizaje más efectivo y satisfactorio en la modalidad presencial. Esto podría deberse a una serie de factores, como la interacción directa con profesores y compañeros, la accesibilidad a recursos físicos en el campus universitario y una mayor estructura en las clases presenciales.

ABSTRACT Purpose: To analyze the prevalence of lower urinary tract symptoms (LUTS) in patients who survived moderate and severe forms of COVID-19 and the risk factors for LUTS six months after hospitalization. Materials and Methods: In this prospective cohort study, patients were evaluated six months after hospitalization due to COVID-19. LUTS were assessed using the International Prostate Symptom Score. General health was assessed through the Hospital Anxiety and Depression Scale and the EQ5D-L5 scale, which evaluates mobility, ability to perform daily activities, pain and discomfort and completed a self-perception health evaluation. Results: Of 255 participants, 54.1% were men and the median age was 57.3 [44.3 – 66.6] years. Pre-existing comorbidities included diabetes (35.7%), hypertension (54.5%), obesity (30.2%) and physical inactivity (65.5%). One hundred and twenty-four patients (48.6%) had a hospital stay >15 days, 181 (71.0%) were admitted to an ICU and 124 (48.6%) needed mechanical ventilation. Median IPSS was 6 [3-11] and did not differ between genders. Moderate to severe LUTS affected 108 (42.4%) patients (40.6% men and 44.4% women; p=0.610). Nocturia (58.4%) and frequency (45.9%) were the most prevalent symptoms and urgency was the only symptom that affected men (29.0%) and women (44.4%) differently (p=0.013). LUTS impacted the quality of life of 60 (23.5%) patients with women more severely affected (p=0.004). Diabetes, hypertension, and self-perception of worse general health were associated with LUTS. Conclusions: LUTS are highly prevalent and bothersome six months after hospitalization due to COVID-19. Assessment of LUTS may help ensure appropriate diagnosis and treatment in these patients. Purpose (LUTS COVID19 COVID 19 COVID-1 Methods study COVID19. 19. Score EQ5DL5 EQDL EQ5D L5 EQ D L EQ5D-L scale mobility activities selfperception self perception evaluation Results 25 participants 541 54 1 54.1 573 57 3 57. 44.3 443 44 [44. 66.6 666 66 years Preexisting Pre existing 35.7%, 357 35.7% , 35 7 (35.7%) 54.5%, 545 54.5% 5 (54.5%) 30.2% 302 30 2 (30.2% 65.5%. 655 65.5% . 65 (65.5%) twentyfour twenty four 48.6% 486 48 (48.6% 15 >1 days 18 71.0% 710 71 0 (71.0% 12 ventilation 311 11 [3-11 genders 10 42.4% 424 42 4 (42.4% 40.6% 406 40 (40.6 444 44.4 p=0.610. p0610 p p=0.610 610 p=0.610) 58.4% 584 58 (58.4% 45.9% 459 45 9 (45.9% 29.0% 290 29 (29.0% (44.4% p=0.013. p0013 p=0.013 013 (p=0.013) 23.5% 235 23 (23.5% p=0.004. p0004 p=0.004 004 (p=0.004) Diabetes Conclusions COVID1 COVID- DL EQ5DL EQD 54. 44. [44 66. 35.7 (35.7% 54.5 (54.5% 30.2 (30.2 65.5 (65.5% 48.6 (48.6 > 71.0 (71.0 31 [3-1 42.4 (42.4 40.6 (40. p061 p=0.61 61 58.4 (58.4 45.9 (45.9 29.0 (29.0 (44.4 p001 p=0.01 01 (p=0.013 23.5 (23.5 p000 p=0.00 00 (p=0.004 [4 35. (35.7 (54.5 30. (30. 65. (65.5 48. (48. 71. (71. [3- 42. (42. 40. (40 p06 p=0.6 58. (58. 45. (45. 29. (29. (44. p00 p=0.0 (p=0.01 23. (23. (p=0.00 [ (35. (54. (30 (65. (48 (71 [3 (42 (4 p0 p=0. (58 (45 (29 (44 (p=0.0 (23 (35 (54 (3 (65 (7 ( p=0 (5 (2 (p=0. (6 p= (p=0 (p= (p

ABSTRACT The COVID-19 pandemic has reduced access to food and increased food insecurity. The objectives were to analyse the prevalence of Food and Nutritional Insecurity (FNI) in Brazilian adolescents during the COVID-19 pandemic according to sociodemographic characteristics and to examine the association between FNI and risk and protective behaviours in Brazilian adolescents during the that period. Cross-sectional study with data from the ‘ConVid teenagers – Behaviour Survey,’ carried out between June and October 2020, using a self-administered questionnaire via mobile phone or computer. The population was made up of teenagers aged 12 to 17, totalling 9,470. The Prevalence Ratio (PR) and 95% Confidence Interval (95% CI) were used, using Poisson regression with robust variance. The prevalence of FNI (26.1%) was higher among adolescents of black and mixed race/colour and who study in public schools. Adolescents who reported FNI had lower consumption of vegetables and fruits, less physical activity, and greater use of cigarettes and alcohol. FNI was more prevalent in adolescents with worse socioeconomic conditions, and adolescents with FNI showed a higher frequency of health risk behaviours, highlighting the importance of intersectoral public policies to reduce inequalities. COVID19 COVID 19 COVID-1 insecurity (FNI period Crosssectional Cross sectional ConVid Survey, Survey 2020 selfadministered self administered computer 1 17 9470 9 470 9,470 PR (PR 95 (95 CI used variance 26.1% 261 26 (26.1% racecolour race colour schools fruits activity alcohol conditions inequalities COVID1 COVID- 202 947 47 9,47 (9 26.1 2 (26.1 20 94 4 9,4 ( 26. (26. 9, (26 (2

RESUMO A pandemia de covid-19 reduziu o acesso aos alimentos e aumentou a insegurança alimentar. Objetivouse analisar a prevalência de Insegurança Alimentar e Nutricional (IAN) em adolescentes brasileiros durante a pandemia de covid-19 segundo características sociodemográficas e examinar a associação entre IAN e comportamentos de risco e proteção em adolescentes brasileiros durante esse período. Estudo transversal com dados da ‘ConVid Adolescentes – Pesquisa de Comportamentos’, realizada entre junho e outubro de 2020, utilizando-se um questionário autoaplicado por meio de celular ou computador. A população foi adolescentes de 12 a 17 anos, totalizando 9.470. Utilizou-se a Razão de Prevalência (RP) e Intervalo de Confiança de 95% (IC95%), por meio da regressão de Poisson com variância robusta. A prevalência de IAN (26,1%) foi mais elevada entre os adolescentes da raça/cor preta e parda e que estudam em escola pública. Os adolescentes que relataram IAN tiveram menor consumo de hortaliças e frutas, menor prática de atividade física e maior uso de cigarros e álcool. A IAN foi mais prevalente em adolescentes com piores condições socioeconômicas, e, adolescentes com IAN apresentaram maior frequência de comportamentos de risco para a saúde evidenciando a importância de políticas públicas intersetoriais para a redução de desigualdades. covid19 covid 19 covid-1 alimentar (IAN período ConVid Comportamentos, Comportamentos , Comportamentos’ 2020 utilizandose utilizando se computador 1 anos 9470 9 470 9.470 Utilizouse Utilizou RP (RP 95 IC95%, IC95 IC IC95% (IC95%) robusta 26,1% 261 26 (26,1% raçacor raça cor pública frutas álcool socioeconômicas desigualdades covid1 covid- 202 947 47 9.47 IC9 (IC95% 26,1 2 (26,1 20 94 4 9.4 (IC95 26, (26, 9. (IC9 (26 (IC (2 (

Abstract: The Research Ethics Committee (CEP) has become an essential mechanism for social control in Brazilian research involving human subjects, contributing to the development of studies guided by ethical standards and to the protection of research participants. This article analyzes the performance of CEP in Western Amazonian institution, its history, operating conditions, trends, and different aspects between 2018 to 2022. The theoretical framework addresses the history of research involving human subjects, the origins and evolution of bioethics in the international context, bioethics in Brazil, and regulations on the ethical analysis of research. The data were collected through the Brazil Platform and reports from the institution's CEP. The CEP evaluated 865 research protocols, most of which were from Health Sciences. Additionally, it was observed that during 2018 to 2022 the covid-19 pandemic had a negative impact on the number of projects submitted for evaluation to the CEP. The 57% drop in the number of projects registered during 2020/2022 reveals the negative impact of this event on the execution of projects with human participants.

Resumo: Os Comitês de Ética em Pesquisa (CEPs) tornaram-se um mecanismo essencial para o controle social em pesquisas brasileiras envolvendo sujeitos humanos, contribuindo para o desenvolvimento de estudos regido por padrões éticos e para a proteção de participantes de pesquisas. Esse artigo analisa o desempenho de CEP em instituição da Amazonia Ocidental, sua história, condições operativas, tendências e diferentes aspectos entre 2018 e 2022. O enquadre teórico visa a história da pesquisa envolvendo sujeitos humanos, as origens e evolução da bioética no contexto internacional, bioética no Brasil e regulamentos de análise ética de pesquisa. Os dados foram coletados através da Plataforma Brasil e relatórios do CEP da instituição. O CEP avaliou 865 protocolos de pesquisa, a maioria deles de Ciências da Saúde. Adicionalmente, foi observado que de 2018 a 2022 a pandemia da covid-19 teve um impacto negativo no número de projetos submetidos para avaliação do CEP. A queda de 57% no número de projetos registrados em 2020/2022 revela o impacto negativo desse evento na execução de projetos com participantes humanos.

Resumen: El Comité de Ética en Investigación (CEP) se ha convertido en un mecanismo esencial para el control social en la investigación brasileña con seres humanos, contribuyendo al desarrollo de estudios guiados por normas éticas y a la protección de los participantes en la investigación. Este artículo analiza el desempeño del CEP en la institución amazónica occidental, su historia, condiciones de funcionamiento, tendencias y diferentes aspectos entre 2018 y 2022. El marco teórico aborda la historia de la investigación con seres humanos, los orígenes y la evolución de la bioética en el contexto internacional, la bioética en Brasil y la normativa sobre el análisis ético de la investigación. Los datos se recogieron a través de la Plataforma Brasil y de informes del CEP de la institución. El CEP evaluó 865 protocolos de investigación, la mayoría de los cuales eran de Ciencias de la Salud. Además, se observó que durante 2018 a 2022 la pandemia de covid-19 tuvo un impacto negativo en el número de proyectos presentados para evaluación al CEP. La caída del 57% en el número de proyectos registrados durante 2020/2022 revela el impacto negativo de este evento en la ejecución de proyectos con participantes humanos.