SUMMARY OBJECTIVE: Phyllodes tumors in the breast are exceptionally uncommon fibroepithelial tumors. In the literature, they are typically categorized as benign phyllodes tumor, borderline phyllodes tumor, and malignant phyllodes tumor. This study aims to assess and present the clinical and surgical outcomes of patients diagnosed with phyllodes tumor. METHODS: The outcomes of patients aged 18 years and above diagnosed with phyllodes tumor between 2006 and 2023 were retrospectively reviewed. Patients were grouped as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared by clinical and surgical results. RESULTS: Of all 57 patients with phyllodes tumor, 64.9% (n=37) were benign phyllodes tumor and 35.1% (n=20) were borderline/malignant phyllodes tumor [22.8% (n=13) borderline phyllodes tumor and 12.3% (n=7) malignant phyllodes tumor]. When the patients were divided into two groups as benign phyllodes tumor and borderline/malignant phyllodes tumor and compared, our cumulative (total) recurrence rate was 14.0%, with final surgical margin width between groups [(0<final surgical margin<2 mm vs final surgical margin≥2 mm) (p=0.154)] and recurrence [(8.1% benign phyllodes tumor vs 25.0% borderline/malignant phyllodes tumor) (p=0.080)]; there was no significant difference between our rates. CONCLUSION: Phyllodes tumors of the breast can be followed up with a narrow negative surgical margin (0 mm<final surgical margin<2 mm). However, after the initial surgery, re-excision is recommended for positive margins, while a wider surgical margin (≥10 mm) is not necessary for excision. OBJECTIVE literature METHODS 1 200 202 reviewed borderlinemalignant results RESULTS 5 649 64 9 64.9 n=37 n37 n 37 (n=37 351 35 35.1 n=20 n20 20 (n=20 22.8% 228 22 8 [22.8 n=13 n13 13 (n=13 123 12 3 12.3 n=7 n7 7 (n=7 . tumor] total (total 140 14 0 14.0% 0<final 0final margin2 2 margin< margin≥ p=0.154 p0154 p 154 (p=0.154) 8.1% 81 [(8.1 250 25 25.0 p=0.080 p0080 080 (p=0.080)] rates CONCLUSION ( mmfinal mm. However surgery reexcision re excision margins ≥10 10 (≥1 6 64. n=3 n3 (n=3 35. n=2 n2 (n=2 22.8 [22. n=1 n1 (n=1 12. n= (n= 14.0 p=0.15 p015 15 (p=0.154 8.1 [(8. 25. p=0.08 p008 08 (p=0.080) ≥1 (≥ 22. [22 (n 14. p=0.1 p01 (p=0.15 8. [(8 p=0.0 p00 (p=0.080 ≥ [2 p=0. p0 (p=0.1 [( (p=0.08 [ p=0 (p=0. (p=0.0 p= (p=0 (p= (p

Abstract French artist Sophie Calle (born in Paris in 1953) has been characterized by a hybrid and often unclassifiable body of work. In her pieces, photography, video, and installation converge, alongside autobiographical, logbook, and correspondence writing. Building upon theoretical and conceptual discussions surrounding the textual and visual shifts in thought production, as well as the autobiographical dimension in art, this article aims to explore how Calle integrates and intersects visuality and writing in her work. It delves into how these strategies shape an unprecedented and hybrid–borderline and imperfect–space for autobiographical narrative, impacting the ways in which art addresses one of its central themes: presentation and representation, as well as the notions of truth and fiction inherent within them.

Resumen La artista francesa Sophie Calle (París, 1953) se ha caracterizado por un trabajo híbrido y muchas veces inclasificable. En sus obras se dan cita de igual forma tanto la fotografía, el video y la instalación como la escritura autobiográfica, de bitácora y de correspondencia. A partir de la discusión teórica y conceptual sobre el giro textual y giro visual en la producción de pensamiento y de la dimensión autobiográfica en el arte, en este artículo me propongo explorar los modos en que se reúnen y cruzan visualidad y escritura en la obra de Calle y cómo estas estrategias configuran un lugar inédito e híbrido –fronterizo e imperfecto– para el relato autobiográfico, repercutiendo en las formas con que el arte aborda uno de sus temas centrales, esto es, la presentación y la representación, y las nociones de verdad y ficción contenidas en ellas.

BACKGROUND. Uterine balloon tamponade (UBT) is used as part of the post partum haemorrhage (PPH) algorithm for the treatment of PPH. OBJECTIVES. The free-flow Ellavi uterine balloon controls the pressure in the uterine balloon by adjusting the height of the supply bag above the patient and allows for expulsion of water from the balloon. The study quantified the volume shifts in the supply bag and assessed the optimal use of the Ellavi UBT by reducing the intrauterine pressure at regular intervals. METHODS. A prospective descriptive study of consecutive patients with refractory PPH was conducted. For group A, the supply bag was weighed every 30 minutes with a sensitive digital scale. Additionally, for group B the supply bag was lowered by 50% and the uterus gently massaged for 30 seconds. RESULTS. Thirteen patients were included in the study. The mean volume was 23.5 mL for Group A and 132.7 mL for Group B. The difference in the means of groups A and B was borderline significant (p=0.06). CONCLUSION. The study did find volume shifts in the free-flow system, which may be enhanced by lowering the supply bag halfway at regular intervals.

Abstract Autism Spectrum Disorders (ASD) and Attention Defi cit Hyperactivity Disorders (ADHD) are Neurodevelop mental Disorders (ND) that frequently coexist together and have etiological, biological, and clinical factors in common. The comorbidity of both neurodevelopmental disorders is associated with a delay or lack of ASD di agnosis and the development of perceptual, emotional, cognitive and behavioral alterations related to Emotional Dysregulation (ED) is common. When both TN are not diagnosed in childhood, they frequently receive wrong diagnoses at later ages, the most frequent being Border line Personality Disorder (BPD). The clinical presentation of the association of ASD and ADHD, the association with ED, differentiation of BPD, and evaluation and intervention are here analyzed. The comorbidity ASD, ADHD, ED is a more severe disorder associated to polypharmacology and hospital admissions.

Resumen Los Trastornos del Espectro Autista (TEA) y los Tras tornos por Déficit de Atención Hiperactividad (TDAH) son Trastornos del Neurodesarrollo (TN) que coexisten frecuentemente y que tienen factores etiológicos, bio lógicos, clínicos en común. La comorbilidad de ambos TN se asocia a un retraso en el diagnóstico del TEA o un diagnóstico que nunca llegan a recibir y es frecuente el desarrollo de alteraciones perceptivas, emocionales, cognitivas y conductuales relacionadas con la Desregu lación Emocional (DE). Cuando ambos TN no son diag nosticados en infancia, frecuentemente reciben diag nósticos equivocados en edades más tardías, siendo el más frecuente el Trastorno Límite de Personalidad (TLP). Se analiza la presentación clínica de la asociación del TEA y el TDAH, la asociación con DE, diferenciación del TLP y evaluación e intervención. La comorbilidad TEA, TDAH, DE, es un trastorno más severo, asociado a poli farmacología y a ingresos hospi talarios.

Resumen Los rasgos límites de personalidad (TLP) se han visto asociados a violencia en la pareja, con investigaciones centradas especialmente en quienes la ejercen. El objetivo de esta revisión sistemática es analizar esta relación tanto en víctimas como en perpetradores, utilizando 17 artículos científicos publicados entre 2017 y 2021 en distintas bases de datos. Los estudios analizados se centraron mayoritariamente en perpetradores, encontrándose tanto hombres como mujeres igualmente representadas. En cambio, los estudios sobre víctimas atendían por lo general a mujeres. A lo largo de esta revisión, se mencionan distintos factores observados en personas que presentan rasgos TLP y ejercen o son víctimas de violencia de pareja, encontrando particularidades en cada perfil. Este trabajo permite incrementar el conocimiento sobre la relación existente entre TLP y violencia de pareja, fomentando una mayor comprensión que repercuta positivamente en la intervención clínica de esta población.

Abstract Borderline personality (BPD) features and intimate partner violence (IPV) have been seen associated, focusing the research specially into perpetrators. The achievement of this systematic review is to analyze this relation in both victims and perpetrators, using 17 scientific articles published between 2017 and 2021 from different data bases. Most studies were focused on perpetrators, in which both men and women were equally represented as perpetrators. Instead, studies about victims were focused on women. Throughout this review, different factors observed in people with BPD traits who are victims or perpetrators of IPV are mentioned, finding particularities in each profile. These findings allow increase knowledge about the relationship between BPD and IPV, promoting a greater understanding that impacts positively on clinical intervention in this population.

Abstract: Extensive intraventricular hemorrhage (IVH) in very preterm newborns (VPNB) is associated with mortality and severe long-term neurological sequelae. Objectives: To know the most frequent neurological pathologies associated with extensive IVH, to determine the functional outcomes of mobility in the motor area and intellectual capacity in the cognitive area, to analyze the association between both areas and to know the schooling achieved. Patients and Method: Descriptive and longitudinal study in VPNB with extensive IVH born between 2001 and 2014. They underwent protocolized neurological follow-up until school age. The functional outcomes in mobility and intellectual capacity were categorized into 4 levels: level 1 corresponds to good functionality and autonomy; level 2, functionality that allows independence, with support in some tasks; level 3 requires constant external support; and level 4 where there is total dependence. The association was analyzed using Chi-square and Cramer’s V coefficient. Results: 74 children completed the follow-up; the most frequent associated neurological pathologies were neurodevelopmental disorders, hypertensive hydrocephalus, and epilepsy. Independent mobility (normal or with limitations) reached 74.4% while 24.3% used wheelchairs. 51.3% was categorized as normal to borderline intellectual range, 12.2% as mild intellectual disability (ID), 17.6% as moderate ID, and 19.9% as severe to profound ID. There was a strong statistical association between functional levels of mobility and intellectual capacity (p < 0.000 and V = 0.62). Schooling was proportional to intellectual capacity: 56.8% attended regular schools, 27.0% attended special schools, and 16.2% had no schooling. Conclusions: 2/3 VPNB with extensive IVH showed positive functional outcomes, from normal to mild limitations that allow an almost autonomous life; in 1/3 the outcomes were unfavorable in mobility and cognitive performance, and there was a strong statistical correlation between both areas studied. Schooling was consistent with the intellectual level.

Resumen: La hemorragia intraventricular extensa (HIVE) en niños muy prematuros (NMP) conlleva mortalidad y graves secuelas a largo plazo. Objetivos: Conocer las patologías neurológicas más frecuentes asociadas a HIVE, determinar los resultados funcionales de movilidad en el área motora y capacidad intelectual en el área cognitiva, analizar la asociación entre ambas áreas y conocer la escolaridad alcanzada. Pacientes y Método: Estudio descriptivo y longitudinal en NMP con HIVE nacidos entre 2001 y 2014, se les realizó seguimiento neurológico protocolizado hasta la edad escolar. Los resultados funcionales en movilidad y capacidad intelectual fueron categorizados en 4 niveles: nivel 1 corresponde a buena funcionalidad y autovalencia; nivel 2, funcionalidad que permite independencia, con apoyo en algunas tareas; nivel 3 requiere de un constante apoyo externo; y nivel 4 en que existe una total dependencia. Para la asociación se usó Chi cuadrado y coeficiente V de Cramer. Resultados: Se incluyeron 74 niños, las patologías neurológicas más frecuentes fueron trastornos del neurodesarrollo, hidrocefalia hipertensiva y epilepsia. La movilidad independiente (normal o con limitaciones) alcanzó un 74,4% y con silla de ruedas el 24,3%. El 51,3% se categorizó en rango intelectual normal a limítrofe, con discapacidad intelectual leve un 12,2%, moderada un 17,6% y severa a profunda un 19,9%. Hubo fuerte asociación estadística entre niveles funcionales de movilidad y capacidad intelectual (p < 0,000 y V = 0,62). La escolaridad fue proporcional a la capacidad intelectual; el 56,8% asistió a escuelas regulares, 27,0% a escuelas especiales y el 16,2% sin escolaridad. Conclusión: 2/3 de los NMP con HIVE mostraron resultados funcionales positivos, desde normal a leves limitaciones que permiten una vida casi autónoma, en 1/3 los resultados fueron desfavorables en movilidad y desempeño cognitivo, hubo fuerte correlación estadística entre ambas áreas estudiadas. La escolaridad fue concordante con el nivel intelectual.

Abstract: Extensive intraventricular hemorrhage (IVH) in very preterm newborns (VPNB) is associated with mortality and severe long-term neurological sequelae. Objectives: To know the most frequent neurological pathologies associated with extensive IVH, to determine the functional outcomes of mobility in the motor area and intellectual capacity in the cognitive area, to analyze the association between both areas and to know the schooling achieved. Patients and Method: Descriptive and longitudinal study in VPNB with extensive IVH born between 2001 and 2014. They underwent protocolized neurological follow-up until school age. The functional outcomes in mobility and intellectual capacity were categorized into 4 levels: level 1 corresponds to good functionality and autonomy; level 2, functionality that allows independence, with support in some tasks; level 3 requires constant external support; and level 4 where there is total dependence. The association was analyzed using Chi-square and Cramer’s V coefficient. Results: 74 children completed the follow-up; the most frequent associated neurological pathologies were neurodevelopmental disorders, hypertensive hydrocephalus, and epilepsy. Independent mobility (normal or with limitations) reached 74.4% while 24.3% used wheelchairs. 51.3% was categorized as normal to borderline intellectual range, 12.2% as mild intellectual disability (ID), 17.6% as moderate ID, and 19.9% as severe to profound ID. There was a strong statistical association between functional levels of mobility and intellectual capacity (p < 0.000 and V = 0.62). Schooling was proportional to intellectual capacity: 56.8% attended regular schools, 27.0% attended special schools, and 16.2% had no schooling. Conclusions: 2/3 VPNB with extensive IVH showed positive functional outcomes, from normal to mild limitations that allow an almost autonomous life; in 1/3 the outcomes were unfavorable in mobility and cognitive performance, and there was a strong statistical correlation between both areas studied. Schooling was consistent with the intellectual level.

Resumen: La hemorragia intraventricular extensa (HIVE) en niños muy prematuros (NMP) conlleva mortalidad y graves secuelas a largo plazo. Objetivos: Conocer las patologías neurológicas más frecuentes asociadas a HIVE, determinar los resultados funcionales de movilidad en el área motora y capacidad intelectual en el área cognitiva, analizar la asociación entre ambas áreas y conocer la escolaridad alcanzada. Pacientes y Método: Estudio descriptivo y longitudinal en NMP con HIVE nacidos entre 2001 y 2014, se les realizó seguimiento neurológico protocolizado hasta la edad escolar. Los resultados funcionales en movilidad y capacidad intelectual fueron categorizados en 4 niveles: nivel 1 corresponde a buena funcionalidad y autovalencia; nivel 2, funcionalidad que permite independencia, con apoyo en algunas tareas; nivel 3 requiere de un constante apoyo externo; y nivel 4 en que existe una total dependencia. Para la asociación se usó Chi cuadrado y coeficiente V de Cramer. Resultados: Se incluyeron 74 niños, las patologías neurológicas más frecuentes fueron trastornos del neurodesarrollo, hidrocefalia hipertensiva y epilepsia. La movilidad independiente (normal o con limitaciones) alcanzó un 74,4% y con silla de ruedas el 24,3%. El 51,3% se categorizó en rango intelectual normal a limítrofe, con discapacidad intelectual leve un 12,2%, moderada un 17,6% y severa a profunda un 19,9%. Hubo fuerte asociación estadística entre niveles funcionales de movilidad y capacidad intelectual (p < 0,000 y V = 0,62). La escolaridad fue proporcional a la capacidad intelectual; el 56,8% asistió a escuelas regulares, 27,0% a escuelas especiales y el 16,2% sin escolaridad. Conclusión: 2/3 de los NMP con HIVE mostraron resultados funcionales positivos, desde normal a leves limitaciones que permiten una vida casi autónoma, en 1/3 los resultados fueron desfavorables en movilidad y desempeño cognitivo, hubo fuerte correlación estadística entre ambas áreas estudiadas. La escolaridad fue concordante con el nivel intelectual.

ABSTRACT Purpose To investigate if the narrative score of the ProNOH protocol allows for discriminating age groups, as well as its relation with the global coherence level of the story. The performance of preschool and schoolchildren on the macrostructure aspects. Methods Participants were 97 preschoolers and schoolchildren with typical language development, aged between five and 12 years old, and both sexes who attended public schools. The “Protocolo de Avaliação da Narrativa Oral de História (ProNOH)” (Protocol for the Evaluation of Oral Storytelling) was applied and the narrative score in the macrostructure dimension was calculated with story grammar elements. These same story elements were used to obtain the global coherence level of the story, as proposed by Spinillo and Martins (1997). Results A statistically significant difference was found between age groups, mainly between the borderline ages of 5-6 years, 7-8 years, 9-10 years, and 11-12 years. Positive and statistically significant correlations were found between the narrative score and global coherence and age, as well as between the narrative score and global coherence. Conclusion The protocol proved to be useful for identifying the repertoire of typical story grammar elements as an objective measure that differs in oral narrative across age groups. The results also indicate that the narrative score can provide an idea about the global coherence of the story, although this value does not replace a specific analysis. groups aspects 9 development 1 old schools Protocolo (ProNOH) Protocol Storytelling 1997. 1997 . (1997) 56 5 6 5- 78 7 8 7- 910 10 9-1 1112 11 11-1 analysis (ProNOH 199 (1997 91 9- 111 11- 19 (199 (19 (1 (

RESUMO Objetivo Investigar se o escore narrativo obtido por meio da aplicação do “Protocolo de Avaliação da Narrativa Oral de História (ProNOH)” permite discriminar os grupos etários estudados, bem como sua relação com o nível de coerência global da história. Método Participaram 97 pré-escolares e escolares com desenvolvimento típico de linguagem, entre 5 e 12 anos, ambos os sexos que frequentavam escola pública. Foi aplicado o “Protocolo de Avaliação da Narrativa Oral de História (ProNOH)” e calculado o escore narrativo na dimensão macroestrutural a partir dos elementos estruturais previstos no modelo da gramática de história. Esses mesmos elementos foram usados para obter o nível de coerência global da história, segundo proposta de análise de Spinillo e Martins (1997). Resultados Diferença estatisticamente significante foi encontrada entre os grupos etários, principalmente entre as idades fronteiriças de 5-6 anos, 7-8 anos, 9-10 anos e 11-12 anos. Correlação positiva e estatisticamente significante foi encontrada com a idade e o escore narrativo e a coerência global, bem como entre o escore narrativo e o nível de coerência global. Conclusão O protocolo mostrou ser útil para identificar o repertório de elementos típicos da gramática de história na narrativa oral como uma medida objetiva que diferenciou a narrativa oral de grupos etários. Os resultados indicaram ainda que o escore narrativo pode ser uma medida norteadora do nível de coerência da história, apesar deste valor não substituir uma análise específica. Protocolo ProNOH (ProNOH) estudados 9 préescolares pré linguagem 1 pública 1997. 1997 . (1997) 56 6 5- 78 7 8 7- 910 10 9-1 1112 11 11-1 específica (ProNOH 199 (1997 91 9- 111 11- 19 (199 (19 (1 (

ABSTRACT Phyllodes Tumor is a rare fibroepithelial neoplasm that represents 0.3 to 1% of all breast neoplasms. According to histopathologic classification, 12 to 26% are borderline type and approximately 15% of these tumors recur after surgical excision. The recommended treatment for all types of Phyllodes Tumor is surgical excision, and in the case of giant tumors, the treatment should be multidisciplinary. We present the case of a 46-year-old woman with a Phyllodes Tumor in the left breast that recurred 4 years after surgical excision. The anatomopathological study qualified it as a giant tumor and the histopathological study reported a Borderline Phyllodes Tumor. She underwent surgical excision with a left mastectomy and breast reconstruction employing a latissimus dorsi flap plus fat graft. The patient presented a favorable evolution without recurrence. In conclusion, the Recurrent Giant Borderline Phyllodes tumor is rare and its surgical management represents a challenge both in breast excision and reconstruction. 03 0 3 0. 1 neoplasms classification 26 15 multidisciplinary 46yearold yearold 46 year old graft recurrence conclusion 2

RESUMO O tumor filoide é uma neoplasia fibroepitelial rara que representa 0,3 a 1% de todas as neoplasias mamárias. De acordo com a classificação histopatológica, 12 a 26% são do tipo borderline e aproximadamente 15% desses tumores recorrem após excisão cirúrgica. O tratamento recomendado para todos os tipos de tumor filoide é a excisão cirúrgica, e no caso de tumores gigantes o tratamento deve ser multidisciplinar. Apresentamos o caso de uma mulher de 46 anos com tumor filoide na mama esquerda que recorreu 4 anos após a excisão cirúrgica. O estudo anatomopatológico qualificou-o como tumor gigante e o estudo histopatológico relatou tumor filoide borderline. Foi submetida a excisão cirúrgica com mastectomia esquerda e reconstrução mamária com retalho de grande dorsal mais enxerto de gordura. A paciente apresentou evolução favorável sem recidiva. Concluindo, o tumor filoide gigante borderline recorrente é raro e seu manejo cirúrgico representa um desafio tanto na excisão quanto na reconstrução mamária. 03 0 3 0, 1 mamárias histopatológica 26 15 multidisciplinar qualificouo qualificou gordura recidiva Concluindo 2

Abstract Genomic effect variants associated with survival and protection against complex diseases vary between populations due to microevolutionary processes. The aim of this study was to analyse diversity and distribution of effect variants in a context of potential positive selection. In total, 475 individuals of Lithuanian origin were genotyped using high-throughput scanning and/or sequencing technologies. Allele frequency analysis for the pre-selected effect variants was performed using the catalogue of single nucleotide polymorphisms. Comparison of the pre-selected effect variants with variants in primate species was carried out to ascertain which allele was derived and potentially of protective nature. Recent positive selection analysis was performed to verify this protective effect. Four variants having significantly different frequencies compared to European populations were identified while two other variants reached borderline significance. Effect variant in SLC30A8 gene may potentially protect against type 2 diabetes. The existing paradox of high rates of type 2 diabetes in the Lithuanian population and the relatively high frequencies of potentially protective genome variants against it indicate a lack of knowledge about the interactions between environmental factors, regulatory regions, and other genome variation. Identification of effect variants is a step towards better understanding of the microevolutionary processes, etiopathogenetic mechanisms, and personalised medicine. processes total 47 highthroughput throughput andor or technologies preselected pre selected polymorphisms nature significance SLCA SLC A SLC30A factors regions variation mechanisms medicine 4

Abstract Objectives To assess the prevalence and pattern of behavioral problems in children and adolescents with atopic dermatitis (AD) and to study their associations with clinical data and severity. Methods This was a single-center, cross-sectional study of patients (6-17 years) with AD. Assessment of competencies and syndrome scale scores of behavioral problems was performed by applying the Child Behavior Checklist 6-18 (CBCL 6-18) and AD severity using the Eczema Area Severity Index (EASI) score. Results Of the 100 patients with AD, 56% were male, with a mean age of 11±3 years, and 43% had moderate/severe AD. Borderline or abnormal values were found in 75% of the patients for total social competence, 57% for internalization, 27% for externalization, and 18% for aggressive behavior. A higher prevalence of aggressive behavior (27.9% vs. 10.5%; p= 0.02) and sleep disorders (32.6% vs. 15.8%; p= 0.04) was observed in patients with moderate/severe AD than in those with mild AD. Children with current or previous use of immunosuppressants/immunobiological tests had a lower frequency of normal social competence (53% vs. 83%, p= 0.012). Regarding the critical questions, 8% responded affirmatively to suicidal ideation. Conclusion A high prevalence of behavioral problems was observed among children and adolescents with AD, with a predominance of internalizing profiles, mainly anxiety and depression. Children with moderate/severe AD have a higher prevalence of aggressive behaviors and sleep disorders. These findings highlight the importance of multidisciplinary teams, including mental health professionals, in caring for patients with AD. (AD singlecenter, singlecenter single center, center single-center crosssectional cross sectional 617 6 17 (6-1 years 618 18 6-1 CBCL EASI (EASI score 10 56 male 113 11 3 11± 43 moderatesevere moderate severe 75 57 internalization 27 externalization 27.9% 279 9 (27.9 vs 10.5% 105 5 p 0.02 002 0 02 32.6% 326 32 (32.6 15.8% 158 15 8 0.04 004 04 immunosuppressantsimmunobiological immunosuppressants immunobiological 53% 53 (53 83 83% 0.012. 0012 0.012 . 012 0.012) questions ideation profiles depression teams professionals 61 1 (6- 6- 4 7 2 27.9 (27. 10.5 0.0 00 32.6 (32. 15.8 (5 001 0.01 01 (6 27. (27 10. 0. 32. (32 15. ( (2 (3

SUMMARY OBJECTIVE: The aim of this study was to evaluate the effects of permanent placental injury due to a severe acute respiratory syndrome coronavirus 2 infection during pregnancy on feto-placental circulation. METHODS: In this cross-sectional study, 83 pregnant women with planned deliveries were divided into two groups according to their severe acute respiratory syndrome coronavirus 2 infection statuses during pregnancy. Their demographic parameters, obstetric histories, and prenatal risks were evaluated. A prenatal fetal Doppler ultrasound examination was performed for all participants, and umbilical artery and middle cerebral artery Doppler parameters were obtained. Postpartum placentas were examined for pathological findings under appropriate conditions. All placentas were evaluated according to the Amsterdam consensus criteria. Mann-Whitney U test, Student’s t-test, and chi-square test were used for comparisons. RESULTS: Demographic parameters were statistically similar, except that they were borderline significant for gestational weeks at delivery (p=0.044). In the pathological examination of the placenta, regardless of the trimester of exposure to viral infection, perivillous fibrin deposition and villus dystrophic calcification were more common in group 2 (p=0.016 and p=0.048, respectively) than in group 1. In the prenatal Doppler examination between the groups, no statistically significant difference was found for all of the umbilical artery pulsatile index, middle cerebral artery pulsatile index, and cerebro-placental ratio values. CONCLUSION: Severe acute respiratory syndrome coronavirus 2 infection during pregnancy causes an increase in perivillous fibrin deposition and villus dystrophic calcification in the placenta. Placental injury caused by the severe acute respiratory syndrome coronavirus 2 virus does not affect fetal Doppler parameters. OBJECTIVE fetoplacental feto circulation METHODS crosssectional cross sectional 8 histories participants obtained conditions criteria MannWhitney Mann Whitney Students Student s ttest, ttest t t-test chisquare chi square comparisons RESULTS similar p=0.044. p0044 p p=0.044 . 0 044 (p=0.044) placenta p=0.016 p0016 016 (p=0.01 p0048 048 p=0.048 respectively 1 index cerebroplacental cerebro values CONCLUSION p004 p=0.04 04 (p=0.044 p=0.01 p001 01 (p=0.0 p00 p=0.0 (p=0.04 (p=0. p0 p=0. (p=0 p=0 (p= p= (p

Abstract Objective Borderline personality disorder (BPD) is a serious and extremely prevalent mental disorder. Early diagnosis is vital for treatment. However, there are no specific screening instruments validated for Brazilian Portuguese. This study aimed to adapt the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD) to the Brazilian context. The MSI-BPD is a self-report instrument based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), that enables fast and reliable assessment of BPD, with measures of sensitivity (SN) and specificity (SP) similar to the diagnostic interview for the DSM-5 (Structured Clinical Interview for DSM-V Axis II Disorders [SCID-II]), taken as the gold standard. Methods Two independent translations, a synthesis version, back-translation, and analysis by experts were employed to create the final version of the instrument in Brazilian Portuguese. The translated instrument was administered to 1,702 adults aged 18-59 years to verify evidence of validity relating to content, internal structure, relationship with other variables, and reliability. Results The exploratory and confirmatory factor analyses show that the one-factor structure is adequate. The scale showed satisfactory internal consistency (Kuder-Richardson coefficient [KR-20] of Cronbach’s alpha = 0.691) and good test-retest reliability (intraclass correlation coefficient [ICC] = 0.802). Logistic regression analysis using the Personality Inventory for the DSM-5-Brief Form (PID-5-BF) (DSM-5) as reference established an ideal cut-off point of eight symptoms, with adequate SN (0.79) and SP (0.75), similar to the original instrument. The area under the curve (AUC) was 0.830 (95% confidence interval: 0.802-0.858), with a positive predictive value of 89.2%. Conclusion The Brazilian version of the MSI-BPD has adequate psychometric properties for use as a BPD screening tool by clinicians. (BPD treatment However Portuguese MSIBPD MSI (MSI-BPD context selfreport self report th DSM5, DSM5 DSM 5 , (SN (SP DSM- Structured DSMV V SCIDII, SCIDII SCID [SCID-II]) standard translations backtranslation, backtranslation back translation, translation back-translation 1702 1 702 1,70 1859 18 59 18-5 content variables onefactor one KuderRichardson Kuder Richardson KR20 KR 20 [KR-20 Cronbachs Cronbach s 0.691 0691 0 691 testretest test retest intraclass ICC [ICC 0.802. 0802 0.802 . 802 0.802) DSM5Brief DSMBrief Brief PID5BF PIDBF PID BF (PID-5-BF (DSM-5 cutoff cut off symptoms 0.79 079 79 (0.79 0.75, 075 0.75 75 (0.75) AUC (AUC 0830 830 0.83 95% 95 (95 interval 0.8020.858, 08020858 0.858 858 0.802-0.858) 892 89 2 89.2% clinicians [SCID-II] 170 70 1,7 185 18- KR2 [KR-2 0.69 069 69 080 0.80 80 (DSM- 0.7 07 7 (0.7 (0.75 083 83 0.8 9 (9 8020 0.8020.858 0802085 0858 0.85 85 0.802-0.858 8 89.2 [SCID-II 17 1, [KR- 0.6 06 6 08 (DSM 0. (0. ( 0.8020.85 080208 085 0.802-0.85 89. [KR (0 0.8020.8 08020 0.802-0.8 0.8020. 0.802-0. 0.8020 0.802-0 0.802-

Resumo Este estudo transversal teve como objetivo investigar a associação entre defeitos de desenvolvimento do esmalte (DDE) e polimorfismos de nucleotídeo único (SNPs) nos genes que codificam o receptor da vitamina D (VDR) e o hormônio da paratireoide (PTH). Pacientes ortodônticos em tratamento em uma escola Odontologia foram selecionados por amostragem de conveniência. Os DDEs foram avaliados e classificados por um examinador calibrado (Kappa>0,80) através de fotografias intraorais de acordo com os critérios propostos por Ghanim et al. (2015). Os tipos de DDE considerados para análise foram: hipoplasia de esmalte, hipomineralização molar-incisivo (HMI), hipomineralização de segundos molares decíduos (HSMD) e opacidades demarcadas não-HMI/HSMD. O DNA gnômico foi extraído de células bucais. Os SNPs em VDR (rs7975232) e PTH (rs694, rs6256 e rs307247) foram genotipados por PCR em tempo real. As análises estatísticas foram realizadas utilizando o software PLINK (versão 1.03, concebido por Shaun Purcell, EUA). Foram feitos teste de qui-quadrado e teste exato de Fisher com um nível de significância de 5%. Foram incluídos noventa e um (n=91) pacientes (49 do sexo feminino e 42 do sexo masculino) (idade média de 14,1±5,8 anos). A frequência de DDE foi de 38,5% (35 pacientes). As distribuições genotípicas estavam em equilíbrio de Hardy-Weinberg. Não foi encontrada associação estatisticamente significante entre os DDEs e os SNPs avaliados. Foi observada uma associação limítrofe (p=0,09) entre a DDE e o haplótipo CC para o SNP rs7975232 no VDR. Em conclusão, os SNPs seleccionados nos genes VDR e PTH não foram associados à DDE nas amostras estudadas. (DDE (SNPs (VDR PTH. . (PTH) conveniência Kappa>0,80 Kappa080 Kappa 0 80 (Kappa>0,80 al 2015. 2015 (2015) molarincisivo molar incisivo HMI, HMI , (HMI) HSMD (HSMD nãoHMI/HSMD. nãoHMIHSMD HMI/HSMD. não-HMI/HSMD bucais rs (rs7975232 rs694, rs694 (rs694 rs625 rs307247 real versão 103 1 03 1.03 Purcell EUA. EUA EUA) quiquadrado qui quadrado 5 5% n=91 n91 n 91 (n=91 49 (4 4 masculino idade 14158 14 8 14,1±5, anos. anos anos) 385 38 38,5 35 (3 pacientes. pacientes) HardyWeinberg. HardyWeinberg Hardy Weinberg. Weinberg Hardy-Weinberg p=0,09 p009 p 09 (p=0,09 rs797523 conclusão estudadas (PTH Kappa>0,8 Kappa08 (Kappa>0,8 201 (2015 (HMI nãoHMI nãoHMI/HSMD HMIHSMD HMI/HSMD (rs797523 rs69 (rs69 rs62 rs30724 10 1.0 n=9 n9 9 (n=9 ( 1415 14,1±5 3 38, p=0,0 p00 (p=0,0 rs79752 Kappa>0, Kappa0 (Kappa>0, 20 (201 (rs79752 rs6 (rs6 rs3072 1. n= (n= 141 14,1± p=0, p0 (p=0, rs7975 Kappa>0 (Kappa>0 2 (20 (rs7975 (rs rs307 (n 14,1 p=0 (p=0 rs797 Kappa> (Kappa> (2 (rs797 rs30 14, p= (p= rs79 (Kappa (rs79 rs3 (p rs7 (rs7

Abstract This cross-sectional study aimed to investigate the association between developmental defects of enamel (DDE) and single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and parathyroid hormone (PTH). Orthodontic patients receiving treatment at a dental school were selected through convenience sampling. Intra-oral photographs were used to assess DDE, which were classified according to the criteria proposed by Ghanim et al. (2015) by a single calibrated examiner (Kappa>0.80). Enamel hypoplasia, molar-incisor hypomineralization (MIH), hypomimineralized second primary molar (HSPM), and non-MIH/HSPM demarcated opacities were considered for the analysis. Genomic DNA was extracted from buccal cells. The SNPs in VDR (rs7975232) and PHT (rs694, rs6256, and rs307247) were genotyped using real-time polymerase chain reactions (PCR). Statistical analyses were performed using the PLINK software (version 1.03, designed by Shaun Purcell, EUA). Chi-square or Fisher's exact tests were performed at a significance level of 5%. Ninety-one (n=91) patients (49 females and 42 males) (mean age of 14.1±5.8 years) were included. The frequency of DDE was 38.5% (35 patients). Genotype distributions were in Hardy-Weinberg equilibrium. No significant statistical association was found between DDE and the SNPs evaluated. A borderline association (p=0.09) was observed between DDE and the CC haplotype for SNP rs7975232 in VDR. In conclusion, the selected SNPs in VDR and PTH genes were not associated with DDE in the studied samples. crosssectional cross sectional (DDE (SNPs (VDR PTH. . (PTH) sampling Intraoral Intra oral al 2015 (2015 Kappa>0.80. Kappa080 Kappa Kappa>0.80 0 80 (Kappa>0.80) hypoplasia molarincisor incisor MIH, MIH , (MIH) HSPM, HSPM (HSPM) nonMIH/HSPM nonMIHHSPM non MIH/HSPM analysis cells rs (rs7975232 rs694, rs694 (rs694 rs6256 rs307247 realtime real time PCR. PCR (PCR) version 103 1 03 1.03 Purcell EUA. EUA EUA) Chisquare Chi square Fishers Fisher s 5 5% Ninetyone Ninety one n=91 n91 n 91 (n=91 49 (4 4 males mean 14158 14 8 14.1±5. years included 385 38 38.5 35 (3 patients. patients) HardyWeinberg Hardy Weinberg equilibrium evaluated p=0.09 p009 p 09 (p=0.09 rs797523 conclusion samples (PTH 201 (201 Kappa08 Kappa>0.8 (Kappa>0.80 (MIH (HSPM nonMIH MIHHSPM (rs797523 rs69 (rs69 rs625 rs30724 (PCR 10 1.0 n=9 n9 9 (n=9 ( 1415 14.1±5 3 38. p=0.0 p00 (p=0.0 rs79752 20 (20 Kappa0 Kappa>0. (Kappa>0.8 (rs79752 rs6 (rs6 rs62 rs3072 1. n= (n= 141 14.1± p=0. p0 (p=0. rs7975 2 (2 Kappa>0 (Kappa>0. (rs7975 (rs rs307 (n 14.1 p=0 (p=0 rs797 Kappa> (Kappa>0 (rs797 rs30 14. p= (p= rs79 (Kappa> (rs79 rs3 (p rs7 (Kappa (rs7

RESUMO Objetivo O objetivo deste estudo foi examinar os efeitos das características sociodemográficas e do estado de saúde de adultos sobre o letramento nutricional. Métodos Este estudo transversal foi realizado entre adultos (>20 anos) em Ancara, Turquia, entre Abril a Junho de 2022. No formulário, na primeira parte, havia perguntas para determinar características sociodemográficas e estado de saúde dos indivíduos. na segunda parte, o Instrumento de Alfabetização Nutricional adotado em turco foi usado para determinar o estado de alfabetização nutricional dos indivíduos. De acordo com essa escala, uma pontuação acima de 38 foi classificada como “adequada”, uma pontuação entre 29 e 38 como “limítrofe” e uma pontuação abaixo de 29 como “inadequada”. Resultados Participaram deste estudo 676 indivíduos, dos quais 50,6% (n=342) eram mulheres e 49,4% (n=334) eram homens. A média do escore total de alfabetização nutricional dos indivíduos foi de 33,06±3,49. Verificou-se que 9,3% dos indivíduos tinham alfabetização nutricional inadequada, 87,4% tinham alfabetização nutricional limítrofe e 3,3% tinham alfabetização nutricional adequada. Os níveis de alfabetização nutricional foram estatisticamente significativos entre os gêneros, sendo que os níveis de alfabetização nutricional das mulheres foram maiores do que os dos homens (p<0,05). Encontrou-se relação significativa entre escolaridade e alfabetização nutricional (p<0,05). O nível de alfabetização nutricional dos indivíduos com Ensino Médio e Superior se mostrou mais adequado em relação aos indivíduos com Ensino Fundamental e Médio. Conclusão Foi determinado que o gênero e a educação entre as características sociodemográficas têm um efeito significativo na alfabetização nutricional. >20 20 (>2 anos Ancara Turquia 2022 formulário parte escala 3 adequada, adequada , “adequada” 2 “limítrofe inadequada. inadequada . “inadequada” 67 506 50 6 50,6 n=342 n342 n 342 (n=342 494 49 4 49,4 n=334 n334 334 (n=334 3306349 33 06 33,06±3,49 Verificouse Verificou 93 9 9,3 874 87 87,4 3,3 gêneros p<0,05. p005 p p<0,05 0 05 (p<0,05) Encontrouse Encontrou >2 (> 202 “adequada “inadequada 5 50, n=34 n34 34 (n=34 49, n=33 n33 (n=33 330634 33,06±3,4 9, 8 87, 3, p00 p<0,0 (p<0,05 > ( n=3 n3 (n=3 33063 33,06±3, p0 p<0, (p<0,0 n= (n= 3306 33,06±3 p<0 (p<0, (n 330 33,06± p< (p<0 33,06 (p< 33,0 (p 33,

ABSTRACT Objective The aim of this study was examined the effects of sociodemographic characteristics and health status of adults on nutritional literacy. Methods This cross-sectional study was conducted among adults (aged >20 years) in Ankara, Turkey between April to June 2022. The first part of the survey consisted ofquestions aimed at determining the socidemographic characteristics and health status of the individuals. In the second part, the Nutrition Literacy Instrument adopted in Turkish was utilized to assess the nutrition literacy status of the participants. Based on this scale, a score above 38 was classified as “adequate”, a score between 29 and 38 as “borderline” and a score below 29 as “inadequate”. Results In this study 676 individuals was participated, among whom 50.6% (n=342) were women and 49.4% (n=334) were men. The average total nutritional literacy score of the individuals was 33.06±3.49. It was found 9.3% of Individuals had inadequate nutrition literacy, 87.4% had borderline nutrition literacy, and 3.3% had adequate nutrition literacy. Nutrition literacy levels were found to be statistically significant between genders, with women exhibiting greater levels of nutrition literacy than men (p<0.05). Furthermore, a significant relationship was found between education levels and nutritional literacy (p<0.05). Specifically, individuals who graduated from high school and university demonstrated higher levels of nutritional literacy compared to those who graduated from primary and secondary school. Conclusion It has been determined that gender and education among socio-demographic characteristics have a significant effect on nutritional literacy. crosssectional cross sectional aged 20 >2 years Ankara 2022 participants scale 3 adequate, , “adequate” 2 “borderline inadequate. . “inadequate” 67 participated 506 50 6 50.6 n=342 n342 n 342 (n=342 494 49 4 49.4 n=334 n334 334 (n=334 3306349 33 06 33.06±3.49 93 9 9.3 874 87 87.4 3.3 genders p<0.05. p005 p p<0.05 0 05 (p<0.05) Furthermore Specifically socio demographic > 202 “adequate “inadequate 5 50. n=34 n34 34 (n=34 49. n=33 n33 (n=33 330634 33.06±3.4 9. 8 87. 3. p00 p<0.0 (p<0.05 n=3 n3 (n=3 33063 33.06±3. p0 p<0. (p<0.0 n= (n= 3306 33.06±3 p<0 (p<0. (n 330 33.06± p< (p<0 33.06 (p< 33.0 (p 33.