RESUMEN Objetivo: Determinar las características clínicas y epidemiológicas de los pacientes con uveítis no infecciosas que acuden a un hospital universitario de Paraguay. Metodología: Se realizó un estudio observacional, descriptivo de corte transversal, retrospectivo. Se incluyeron casos consecutivos de pacientes que acudieron al Servicio de Oftalmología del Hospital de Clínicas de enero del 2020 a octubre del 2021 y que fueron diagnosticados con uveítis no infecciosa. Las variables estudiadas fueron sexo, edad, procedencia, motivo de consulta, clasificación anatómica, curso clínico, asociación sistémica y ocular y bilateralidad. Resultados: Se revisó los expedientes de 78 pacientes, el 66,7% fue de sexo femenino y 42 pacientes (53,8%) procedían del departamento Central. La localización anatómica anterior de la uveítis fue la más frecuente (53,9%), seguida en orden decreciente por la panuveítis, la posterior y la intermedia. Respecto a las uveítis anteriores, en 24 pacientes (57,1%) fueron unilaterales, en 40 (95,2%) no granulomatosas, 19 (45,2%) presentaron un curso clínico agudo, el motivo de consulta más frecuente fue “ojo rojo y doloroso” con 15 pacientes (35,7%), la asociación sistémica más frecuente fue HLA- B27+ en 16 pacientes (38,1%). En cuanto, a las panuveítis, 13 pacientes (50%) se asociaron con síndrome de Vogt-Koyanagi-Harada y de las posteriores 2 pacientes relacionados a Artritis reumatoidea. Conclusión: El patrón clínico y epidemiológico observado en este estudio es en su mayor parte similar al observado en la mayoría de las series encontradas en la literatura. Llaman la atención en este estudio que las asociaciones más frecuentes son diferentes de los reportados en la literatura: de la anterior, el HLA-B27+; de la posterior, la artritis reumatoidea; y que entre las panuveítis se observa un gran porcentaje de síndrome de Vogt-Koyanagi-Harada.

ABSTRACT Objective: To determine the clinical and epidemiological characteristics of patients with noninfectious uveitis at a university hospital in Paraguay. Methodology: An observational, descriptive, cross-sectional, retrospective study was performed. Consecutive patients who attended the Ophthalmology Service of the Hospital de Clínicas from January 2020 to October 2021 and who were diagnosed with non-infectious uveitis were included. The variables studied were sex, age, origin, reason for consultation, anatomical classification, clinical course, systemic and ocular associations, and bilaterality. Results: A total of 78 medical records of patients meeting the inclusion and exclusion criteria were analyzed. Of the patients, 66.7% were female and 42 (53.8%) were from the Central Department. The anterior anatomical location of uveitis was the most frequent (53.9%), followed in decreasing order by panuveitis, posterior uveitis, and intermediate uveitis. Regarding anterior uveitis, 24 patients (57.1%) had unilateral uveitis, 40 (95.2%) were non-granulomatous, 19 (45.2%) presented an acute clinical course, the most frequent reason for consultation was "red and painful eye" with 15 patients (35.7%), the most frequent systemic association was HLA- B27+ in 16 patients (38.1%). As for panuveitis, 13 patients (50%) were associated with Vogt-Koyanagi-Harada syndrome, and of the latter, two patients were related to rheumatoid arthritis. Conclusion: The clinical and epidemiological patterns observed in this study were largely consistent with those reported in the literature. Notably, the most frequent associations differed from those reported in the literature: HLA-B27+ for anterior uveitis, rheumatoid arthritis for posterior uveitis, and a significant percentage of Vogt-Koyanagi-Harada syndrome among panuveitis cases.

Lumbar spondylolysis is an acquired defect of the pars interarticular process ('isthmus') due to the human species' erect posture. Anatomical and load factors play a role. With lumbar extension, the superior vertebra's inferior articular process drives down dorsally on the inferior pars, causing a ventral tensile stress, bone oedema, fracture, and ultimately nonunion in some. The population incidence is around 6%, where most are inconsequential as they are asymptomatic and have a favourable natural history. In the physically highly active group, especially athletes, back and radicular pain is more common, leading to a three to four times higher incidence of lysis in this group. Although X-rays are typically the first imaging modality used, computed tomography (CT) is far more sensitive and, with staging, more predictive of fusion with comparable radiation dose. Magnetic resonance imaging (MRI) allows identification of bone oedema, a precursor of fracture, and assessment of the disc status. This has replaced previously used isotope bone scans and single-photon emission computed tomography (SPECT). Management involves cessation of physical activity and bracing to block extension for three to six months, with around 90% resolution of symptoms. Union rate is negatively related to bilaterality and terminal stage (nonunion), but not necessarily correlated to symptom/functional status. Surgical intervention in those that fail nonoperative care includes pars repair or fusion, with a high fusion and return to activity rate. The young athlete poses a particular challenge due to return to play pressure, but still does well with nonoperative care and subsequent activity modification. Counselling of the family and sports staff is extremely important when planning treatment in this high-demand group. Level of evidence: Level 5

Abstract This article aims to analyze the hypotheses in which it is possible to replace a unilateral sanction resulting from contractual breaches by an administrative agreement, as well as the criteria to be observed when choosing between an agreement or a unilateral sanctioning act. To this end, an analysis will be made of the normative provisions that authorize the adoption of consensus in the Brazilian Public Administration and the cases in which it is possible to replace the unilateral administrative act with bilaterality. After defining these assumptions, the existence of authorization in Brazilian law for the replacement of unilateral sanctioning activity, within the scope of administrative contracts, by agreements will be analyzed. Then, the guiding criteria that must be used by the Administration to decide between entering into the agreement or applying the unilateral administrative sanction in the event of contractual administrative infractions will be assessed. In the end, the conclusion will assess the decision-making process by the Administration based on such guiding criteria. end bilaterality assumptions activity contracts analyzed Then assessed decisionmaking decision making

Resumo O presente artigo tem como objetivo analisar as hipóteses em que é possível a substituição de sanção unilateral decorrente de infrações contratuais pelo acordo administrativo, bem como os critérios a serem observados para escolha entre o acordo ou o ato unilateral sancionatório. Para tanto, será feita a análise dos dispositivos normativos que autorizam a adoção da consensualidade na Administração Pública brasileira e os casos em que é possível a substituição do ato administrativo unilateral pela bilateralidade. Após a definição dos referidos pressupostos, será analisada a existência de autorização no Direito brasileiro para a substituição da atividade sancionatória unilateral, no âmbito dos contratos administrativos, por acordos. Em seguida, serão apreciados os critérios balizadores que devem ser utilizados pela Administração para decidir entre celebrar o acordo ou aplicar a sanção administrativa unilateral em caso de ocorrência de infrações administrativas contratuais. Ao final, a conclusão apreciará o processo de tomada de decisão pela Administração com base em tais critérios balizadores. sancionatório tanto bilateralidade pressupostos administrativos acordos seguida final

Abstract This study aimed to analyze the root and root canal morphology of mandibular first and second molars using CBCT images. A total of 2,400 mandibular molars exams were selected from 600 patients aged between 18 and 75 years. The number of roots, number of root canals, and root canal configuration according to the Vertucci classification were verified. Overall, 94.92% of mandibular first molars and 90.17% of mandibular second molars had two separate roots. Among the biradicular molars, the first molars showed a greater incidence of type IV canals in the mesial root and type I in the distal root. In the second molars, the most common canal form was type IV in the mesial root and type I in the distal root. In the triradicular molars, the type IV and type I configurations were the most common in the mesial root of the first molar and second molar, respectively. In both triradicular molars, there was a prevalence of type I canal in the distal and DL roots. Statistical analysis was performed at a significance level of 0.05. The number of roots was correlated with gender (Spearman test), and the canal's configuration with gender and bilaterality (Wilcoxon test). The subpopulation studied has a high incidence of bilateral symmetry and mandibular molars with two roots with two distinct mesial canals and one distal canal. The bilateral configuration is possible to estimate the number of canals, especially in images that are difficult to visualize, such as atresic canals.

Resumo Objetivo Descrever o perfil epidemiológico e clínico dos pacientes com doença de Dupuytren tratados por fasciectomia seletiva e os fatores associados com a gravidade da doença. Metodologia Estudo observacional descritivo retrospectivo envolvendo 247 pacientes com doença de Dupuytren, no período de 2013 a 2019. Foi realizada regressão logística multivariada para análise dos dados. Resultados A maioria dos pacientes era do sexo masculino (83,8%), autodeclarados brancos (65,2%), etilistas (59,6%), e 49% eram tabagistas. A média de idade foi de 66 ± 9 anos, sendo que 77,2% apresentaram os sintomas da doença após os 51 anos. Aproximadamente 51,9, 29,6, e 17,3%, respectivamente, apresentaram hipertensão arterial, diabetes mellitus e dislipidemia. O acometimento bilateral das mãos foi observado em 73,3% dos pacientes. A taxa de complicações intra- e pós-fasciectomia seletiva foi de 0,6 e 24,3%, respectivamente, sendo que 5,2% dos pacientes necessitaram de reintervenção após 1 ano de acompanhamento. Após análise multivariada, o sexo masculino foi associado com acometimento bilateral das mãos (odds ratio [OR] = 2,10; intervalo de confiança [IC] 95%: 1,03–4,31) e com maior número de raios acometidos (OR = 3,41; IC 95%: 1,66–7,03). A dislipidemia foi associada com a reintervenção (OR = 5,7; CI 95%: 1,03–31,4) e a bilateralidade com maior número de complicações (35,7% versus 19,7%). Conclusão Foi observada uma baixa taxa de reintervenção e complicações operatórias nos pacientes com doença de Dupuytren tratados por fasciectomia seletiva. O sexo masculino foi associado com o quadro grave da doença (bilateralidade e mais de dois raios acometidos), e a dislipidemia com a reintervenção.

Abstract Objective To describe the epidemiological and clinical profile of patients with Dupuytren disease treated by selective fasciectomy and the factors associated with the severity of the disease. Methods Retrospective descriptive observational study involving 247 patients with Dupuytren disease, from 2013 to 2019. Multivariate logistic regression was performed for data analysis. Results Most patients were male (83.8%), self-declared white (65.2%), alcoholics (59.6%) and 49% were smokers, with a mean age of 66 ± 9 years old, with 77.2% presenting symptoms of the disease after the age of 51 years old. Approximately 51.9, 29.6 and 17.3%, respectively, had arterial hypertension, diabetes mellitus and dyslipidemia comorbidities. Bilateral involvement of the hands was observed in 73.3% of the patients. The rate of intra- and post-selective fasciectomy complications was of 0.6 and 24.3%, respectively, with 5.2% of the patients needing reintervention after 1 year of follow-up. After multivariate analysis, males were associated with bilateral involvement of the hands (odds ratio [OR] = 2.10; 95% confidence interval [CI]: 1.03–4.31) and with a greater number of affected rays (OR = 3.41; 95% CI: 1.66–7.03). Dyslipidemia was associated with reintervention (OR = 5.7; 95% CI = 1.03–31.4) and bilaterality with a higher number of complications (35.7 versus 19.7%). Conclusion A low rate of reintervention and operative complications was observed in patients with Dupuytren disease treated by selective fasciectomy. Male gender was associated with severe disease (bilaterality and more than two affected rays), and dyslipidemia with reintervention.

SUMMARY: The objective of this study was to evaluate the bilaterality and symmetry in C-shaped mandibular second molars in Mexican Maya and non-Maya populations using cone-beam computed tomography (CBCT). Five-hundred-twenty-five CBCT scans of patients with left and right mandibular second molars were analyzed to determine the prevalence and bilaterality. The teeth were assessed for the presence of C-shaped root canals, according to Fan et al. (2004) criteria. The sample was subdivided by ethnicity, sex, unilateral/bilateral presence, side of the longitudinal groove, and the C-shaped root canal configuration and symmetry, at the cervical, middle, and apical cross- sections of the root. C-shaped mandibular second molars were present in 24.95% of the individuals. Most (60.30%) of those showing this trait had it bilaterally. When comparing by ethnicity, sex, and side, we detected no significant differences. The vast majority (97.33%) presented the groove along the lingual side. The C3 was the most prevalent configuration in the overall sample, while in the Maya group, the C1 was the most common configuration. When analyzed by sex and ethnic group, the non-Maya females tended to deviate from the other groups in terms of bilaterality. Overall, 55.70% of bilateral C-shaped mandibular second molars were also symmetric in the three radicular thirds. The prevalence of C-shaped mandibular second molars was similar to that reported for northernAsian populations, which is consistent with the evolutionary origins of Native American populations. Most of the sample showed bilaterality and half were symmetric. Clinicians must be aware of the ethnic background of their patients and consider the possible variations to do more predictable root canal treatments.

RESUMEN: El objetivo de este estudio fue evaluar la bilateralidad y simetría de los segundos molares mandibulares en forma de C en una población Mexicana Maya y no-Maya mediante tomografía computarizada de haz cónico (CBCT). Material and Métodos: Se analizaron quinientos veinticinco tomografías de pacientes con segundos molares mandibularesderecho e izquierdo para determinar la prevalencia y bilateralidad. Los dientes fueron evaluados según la presencia de conductos en forma de C de acuerdo a los criterios de Fan et al. La muestra fue subdividida por etnicidad, sexo, presencia bilateral/unilateral, lado del surco y configuración y simetría de los conductos en los cortes transversales cervical, medio y apical. Los segundos molares mandibulares en forma de C estuvieron presentes en el 24.95 % de los individuos. La mayoría (60.30%) de los que mostraron este rasgo lo hicieron de forma bilateral. El comparar por etnicidad, sexo y lado, no se encontraron diferencias estadísticamente significativas. La gran mayoría (97.33%) presentó el surco por lingual. C3 fue la configuración más prevalente en la muestra general, mientras que en el grupo Maya el C1 fue la más común. El análisis por sexo y grupo étnico arrojó que las mujeres no Mayas tendieron a desviarse de los otros grupos en términos de bilateralidad. El 55.70% de los segundos molares mandibulares bilaterales fueron simétricos en sus tres tercios radiculares. La prevalencia de los segundos molars mandibulares en forma de C fue similar a la reportada para las poblaciones del norte de Asia, lo cual es consistente con los orígenes evolutivos de las poblaciones nativas americanas. La mayor parte de la muestra presentó el rasgo de forma bilateral y la mitad de éstos fueron simétricos. Los odontólogos deben tomar en cuenta el origen étnico de sus pacientes y considerar las posibles variaciones para realizar tratamientos endodónticos más predecibles.

Resumen Introducción: El comportamiento de locomoción de un organismo implica la integración de aspectos como la simetría corporal, los sistemas sensorial y locomotor. Además, varios factores ecológicos parecen estar relacionados con las características de la locomoción, como la estrategia de alimentación, las tendencias migratorias, la respuesta a los depredadores y competidores y el estrés ambiental. Objetivo: Analizar el patrón general de locomoción y la influencia de la simetría corporal en la locomoción y enderezamiento de la estrella de mar Asterina stellifera. Métodos: Realizamos experimentos de laboratorio en acuarios en presencia / ausencia de corriente de agua y en superficie horizontal y vertical. Resultados: La velocidad es similar a la velocidad en otras especies de tamaño similar. Tanto la velocidad como la linealidad del desplazamiento fueron independientes del tamaño corporal individual. Una corriente de agua conduce a una velocidad de desplazamiento mayor y a trayectorias más rectas, pero no hay reotaxis: una corriente de agua no afecta el patrón de locomoción. La velocidad y la linealidad del desplazamiento fueron independientes del tamaño corporal individual. El patrón de desplazamiento aquí descrito puede ser una adaptación de organismos que presentan densas poblaciones en comunidades con alta abundancia de presas, como es el caso de A. stellifera. Conclusiones: Al igual que otros asteroides, esta especie no mostró un plano de simetría Anterior / Posterior durante la locomoción o el movimiento de enderezamiento: no tiende a la bilateralidad.

Abstract Introduction: The locomotion behavior of an organism involves the integration of aspects like body symmetry, sensory and locomotor systems. Furthermore, various ecological factors seem to be related to locomotion characteristics, such as foraging strategy, migration trends, response to predators and competitors, and environmental stress. Objective: To analyze locomotion and the influence of body symmetry in the crawling and righting movements of the sea star Asterina stellifera. Methods: We carried out laboratory experiments in aquariums in the presence/absence of water current and on a horizontal and vertical surface. Results: The speed is similar to speed in other species of similar size. Both the speed and linearity of displacement were independent of individual body size. A water current leads to faster crawling and straight paths, but there is no rheotaxis: streams do not affect locomotion. Speed and linearity of displacement were independent of individual body size. The displacement pattern described here may be an adaptation of organisms that present dense populations in communities with high prey abundance, as is the case of A. stellifera. Conclusions: Like other asteroids, this species did not show an Anterior/Posterior plane of symmetry during locomotion, or righting movement: it does not tend to bilaterality.

ABSTRACT Objective: The objective of the study was to develop an association between clinicopathologic and sonographic features of patients with papillary thyroid microcarcinoma and the prevalence of lymph node metastasis. Subjects and methods: Clinicopathologic and sonographic features of 415 patients of papillary thyroid microcarcinoma with (n = 102) or without (n = 313) lymph node metastasis were retrospectively reviewed. The thickness of the lymph node ≥ 6 mm with intra-lymph nodal occupying lesions considered lymph node metastasis. Also, it was considered metastasis if lymph node perfusion or blood flow defect was found with any thickness size. Univariate following multivariate analysis was performed for the prediction of sonographic features and clinicopathologic factors for the prevalence of lymph node metastasis. Results: Male gender ( p = 0.041), age < 45 years ( p = 0.042), preoperative calcitonin > 65 pg/ mL ( p = 0.039), nodule size > 5 mm in diameter ( p = 0.038), bilaterality ( p = 0.038), tumor capsular invasion ( p = 0.048), cystic change ( p = 0.047), and hyper vascularity ( p = 0.049) of thyroid nodules were associated with lymph node metastasis. Also, thyroid nodules 5 mm and more in diameter may have high aggressiveness. Conclusion: These data helped the surgeon for individualized treatment in thyroid carcinoma and avoid unnecessary prophylactic surgery of the lymph node.

Abstract Introduction: Emphysematous pyelonephritis (EP) is a necrotizing infection of the upper urinary tract, associated with enterobacteria, whose progression is subacute and insidious. Diagnosis is clinical and is corroborated and staged through computed tomography. Management depends on the severity of the case and can range from antimicrobial therapy and surveillance to emergency nephrectomy. Aim: To describe the factors associated with the severity of EP in a population seen at the Urology Service of the Hospital General de México. Materials and methods: A retrospective, observational, analytic study was conducted. The qualitative variables were expressed through simple frequencies and percentage distribution and the quantitative variables were expressed through measures of central tendency. The variables with non-normal distribution were expressed through median and interquartile range. Group comparisons were carried out using the Fisher’s exact test (qualitative variables), the Mann-Whitney U test, and 95% confidence intervals (95% CIs). Odds ratios (ORs) were utilized for the inferential statistics to obtain the relation of each factor to severity. Calculations were made with a 95% CI and a 5% alpha error. Results: The factors associated with EP severity were: bilaterality (OR 7.5, 95% CI 1.56-36.8, p 0.011), renal colic (OR 2.9, 95% CI 0.70-12.4, p 0.01), leukocytosis (OR 1.5, 95% CI 0.44-4.92, p 0.04), thrombocytopenia (OR 3.2, 95% CI 0.29-34.7, p 0.04), Glasgow coma score < 15 (OR 1.3, 95% CI 0.31-3.39, p 0.001), and azotemia (OR 1.5, 95% CI 0.44-4.92, p 0.04). Conclusion: The early identification of those factors can reduce the risk for complications and improve disease progression in patients with EP.

Resumen Introducción: La Pielonefritis Enfisematosa (PE) es una infección necrotizante del tracto urinario superior, asociada a enterobacterias con una evolución subaguda e insidiosa. El diagnóstico es clínico, corroborándose y estadificándose mediante estudio tomográfico. El manejo dependerá de la gravedad del caso, puede ameritar manejo antimicrobiano y vigilancia hasta nefrectomía de urgencia. Objetivo: Describir los factores asociados a gravedad para PE en la población atendida en el servicio de Urología del Hospital General de México. Material y métodos: Estudio observacional, retrospectivo, analítico, obteniéndose para variables cualitativas frecuencias simples y distribución porcentual; para variables cuantitativas, se obtuvieron medidas de tendencia central; para variables con distribución no normal, se obtuvieron mediana y rango intercuartil. La comparación entre grupos se realizó mediante prueba exacta de Fisher (variables cualitativas), y test de U de Mann Whitney e intervalos de confianza al 95% (IC 95%) (variables cuantitativas). La estadística inferencial utilizó razón de momios (RM) para obtener la relación de cada factor para gravedad. Los cálculos fueron realizados con un nivel de confiabilidad de 95% y error alfa de 5%. Resultados: Los factores asociados a gravedad para PE son: bilateralidad (RM 7.5, IC 95 % 1.56-36.8, p 0.011), cólico nefrítico (RM 2.9, IC 95 % 0.70-12.4, p 0.01), leucocitosis (RM 1.5, IC 95 % 0.44-4.92, p 0.04), trombocitopenia (RM 3.2, IC 95% 0.29-34.7, p 0.04), Glasgow <15 (RM 1.3, IC 95 % 0.31-3.39, p 0.001) y Azoemia (RM 1.5, IC 95% 0.44-4.92, p 0.04). Conclusión: La temprana identificación de estos factores permitirá disminuir el riesgo de complicaciones y mejorar la evolución de los pacientes con PE.

SUMMARY: The study of the thyroid veins has not received an investigation as extensive as the thyroid arteries and laryngeal nerves did in relation to thyroid surgery. Of the three veins pedicles of the gland the middle is far the least studied. This vein is inconstant and is the first vascular element of the gland that must be sectioned before the medial lobe is dislocated to evaluate ist posterior relationships. His injury can cause intraoperative bleeding, making it difficult to identify the inferior laryngeal nerve and the parathyroid glands, proximal to it. A descriptive crossseccional study was carried aot evaluating the presence, number, symmetricity and association of the middle thyroid vein with variables such as age and sex of the patient, as well as the hyperfunctionality of the gland and the presence of the Zuckerkandl tubercle in 100 total thyroidectomies undergoing at the National Cancer Institute and the ENT Service of the Social Security Institute´s Central Hospital. The overall prevalence of the middle thyroid vein was 74%. In the right lobe the vein appeared in 60% while in the left lobe in 53 %. Double middle thyroid vein was found in 4 patients, in one of them it was bilateral. The highest percentage of the middle thyroid veins originated in the middle third of the lobe, 72 % on the right and 70% on the left side. No association was found between the presence of the vain and age and sex, the state of glandular hyperfunstion, as well as the presence of Zuckerkandl tubercle.

RESUMEN: El estudio de las venas tiroideas no ha recibido una investigación tan exhaustiva como lo tuvieron las arterias tiroideas y los nervios laríngeos en relación a la cirugía tiroidea.De los tres pedículos venosos de la glándula tiroides, el medio, de lejos es el menos estudiado. La vena tiroidea media es inconstante y es el primer elemento vascular de la glándula tiroides que debe ser seccionado antes de luxar el lóbulo hacia medial para evaluar sus relaciones posteriores. Su lesión puede provocar sangrado intraoperatorio dificultando secundariamente la identificación del nervio laríngeo inferior y las glándulas paratiroides, próximas a la misma. Se realizó un estudio descriptivo de corte transversal evaluando la pesencia, número, simetría y asociación de la vena tiroidea media con variables tales como edad y sexo del paciente, así como la hiperfuncionalidad de la glándula tiroides y la presencia del tubérculo de Zuckerkandl en 100 tiroidectomías totales llevadas a cabo en el Instituto Nacional del Cáncer y en el Servicio de Otorrinolaringología del Hospital Central del Instituto de Previsión Social del Paraguay. La prevalencia global de vena tiroidea media fue del 74 %. En el lóbulo derecho, la vena se presentó en el 60 %, mientras que en el lóbulo izquierdo en el 53 %. En el 38 % se encontró la vena en ambos lóbulos. En 4 pacientes se localizaron venas tiroideas medias dobles, en una de ellas fue bilateral. El mayor porcentaje de las venas tiroideas medias se originó en el tercio medio del lóbulo, el 72 % en el lado derecho y el 70% en el izquierdo. No se encontró asociación entre la presencia de la vena tiroidea media y la edad, sexo, estado de hiperfunción glandular, así como tampoco con la presencia del tubérculo de Zuckerkandl.

Resumo Esclerite Posterior (EP) é uma inflamação do segmento escleral posterior, de etiologia inflamatória ou infecciosa, pouco diagnosticada, com evolução rápida, progressiva e irreversível com severo comprometimento visual, principalmente se o diagnóstico e o tratamento da (EP) não forem realizados a tempo hábil. A dor ocular, dor à movimentação ocular, cefaléia e embaçamento visual são os principais sinais e sintomas. Pode ser de causa Idiopática ou associada a doença sistêmica em até 45% dos caso. A Artrite Reumatoide é descrita como a associação mais comum. Causas infecciosas podem estar presente tais como: Herpes Simples, Herpes Zoster Oftálmico, Sífilis e Tuberculose. A bilateralidade pode ocorrer em até 35% dos casos sendo mais prevalente em mulheres a partir da quinta década de vida.

Abstract Posterior Scleritis (PS) is an inflammation of the posterior scleral segment, of low inflammatory or infectious etiology, with a rapid, progressive and irreversible evolution with severe visual impairment, especially if the diagnosis and treatment of (PS) are not performed in time skillful. Ocular pain, eye movement pain, headache and visual haze are the main signs and symptoms. It can be of idiopathic cause or associated with systemic disease in up to 45% of the cases. Rheumatoid arthritis is described as the most common association. Infectious causes may be present such as: Simple Herpes, Ophthalmic Herpes Zoster, Syphilis and Tuberculosis. Bilaterality can occur in up to 35% of cases being more prevalent in women from the fifth decade of life.

Abstract OBJECTIVE: To analyze the Negative Predictive Value of the Sentinel Lymph Node Selective Biopsy Technique in Endometrial Carcinoma. MATERIALS AND METHODS: Prospective cohort observational study. Carried out in the General University Hospital of Ciudad Real between 2011 and 2016. Patients diagnosed with endometrial carcinoma with stage I-II, suitable for surgical intervention with uterine cervix accessible for marker injection, were included. Patients with involvement of adjacent or distant organs were excluded. 34 variables were studied, for the statistical analysis the SPSS computer program was used. RESULTS: 65 patients were included in the study. 59 of the tumors were endometrial carcinoma type 1 and 6 type 2. The rate of identification of sentinel lymph node in the SPECT TAC was 84% and with dual staining (radiocolloid and methylene blue) of 100%. The sentinel lymph node was located in the pelvic region in 60/65 and in the para-aortic region in 5/65 of the cases, whose most frequent lymph node territory was the lymph nodes adjacent to the external iliac vessels. No cases of metastasis in non-sentinel lymph nodes were detected. The bilaterality rate was 9.2%. The tumor recurrence rate was 3%, with a 5-year survival of 96.9%. CONCLUSIONS: The Negative Predictive Value of the technique was 100%, it is a good alternative to lymphadenectomy. We recommend dual staining injected into the cervix to achieve greater localization of sentinel lymph node.

Resumen : OBJETIVO: Evaluar la utilidad de la biopsia selectiva de ganglio centinela en pacientes con carcinoma de endometrio en estadio inicial, mediante la inyección de tecnecio 99-azul de metileno en el cuello uterino, el valor predictivo negativo de la técnica y conocer la distribución y su tasa de bilateralidad. MATERIALES Y MÉTODOS: Estudio observacional, prospectivo, de cohortes, efectuado en el Hospital General Universitario de Ciudad Real (2011-2016). Criterios de inclusión: pacientes con diagnóstico de carcinoma de endometrio estadio I-II, aptas para intervención quirúrgica con cuello uterino accesible para la inyección del marcador. Criterios de exclusión: pacientes con afectación de órganos adyacentes o a distancia. Se estudiaron 34 variables, para el análisis estadístico se utilizó el programa informático SPSS. RESULTADOS: Se estudiaron 65 pacientes y de éstas 59 tenían carcinoma de endometrio tipo 1 y 6 tipo 2. La tasa de identificación de ganglio centinela en el SPECT TAC fue de 84% y con tinción dual (radiocoloide y azul de metileno) de 100%. El ganglio centinela se localizó en la región pélvica en 60 de 65 y en la región paraaórtica en 5 de 65 casos; el territorio ganglionar más frecuente fueron los ganglios adyacentes a los vasos iliacos externos. No se identificó ningún caso de metástasis en ganglios no centinela. La tasa de bilateralidad fue de 9.2% y la de recidiva tumoral de 3%, con supervivencia a 5 años de 96.9%. CONCLUSIONES: El valor predictivo negativo de la técnica fue de 100%, lo que la convierte en una buena alternativa a la linfadenectomía. Se recomienda la tinción dual inyectada en el cuello uterino para conseguir mayor localización de ganglio centinela.

RESUMO Objetivo: Avaliar a relação entre a razão neutrófilo/linfócito e a presença de sinais de artrose em ambos os quadris em pacientes acompanhados neste serviço. Métodos: Estudo transversal, retrospectivo, que usou análise de prontuários e revisão de banco de dados de pacientes maiores de 18 anos com diagnóstico de artrose de quadril acompanhados no ambulatório deste hospital. Resultado: Com relação à análise do teste de Mann-Whitney para correlacionar a razão neutrófilo/linfócito e a lateralidade, observou-se um resultado de teste bilateral de 0,036, evidenciou desse modo a diferença entre os grupos. Quando os valores absolutos de neutrófilos e linfócitos foram analisados, observaram-se p = 0,14 e p = 0,24, não foi possível observar diferenças estatisticamente significativas entre os valores absolutos nos dois grupos. Conclusões: Considerando-se as interações entre os mecanismos inflamatórios na osteoartrose e o fato de que a interação entre os neutrófilos e os linfócitos tem diferenças com relação à lateralidade da coxartrose, é possível levantar a hipótese de que a etiologia inflamatória da osteoartrose unilateral e da bilateral tem dinâmicas diferentes. Entretanto, são necessários estudos mais aprofundados, com citometria de fluxo, para avaliar o impacto com relação às diferenças nos mecanismos inflamatórios observados nesse estudo.

ABSTRACT Objective: The objective of this study was to evaluate the relationship between the neutrophil/lymphocyte ratio and the presence of signs of arthrosis in both hips in patients followed at this medical center. Methods: This was a cross-sectional, retrospective study through the analysis of medical records and database review of patients over 18 years of age with hip arthrosis, followed at the outpatient clinic of this hospital. Results: Regarding the analysis of the Mann-Whitney test to correlate the neutrophil/lymphocyte ratio and laterality, a bi-lateral test result of p = 0.036 was obtained, thus demonstrating a significant difference between the observed groups. When we analyzed the absolute values of neutrophils and lymphocytes, the authors obtained results of p = 0.14 and p = 0.24. Therefore, it was not possible to observe statistically significant differences between the absolute values in the two groups. Conclusion: Considering the interactions between the inflammatory mechanisms in osteoarthritis and the fact that the interaction between neutrophils and lymphocytes has differences in relation to the laterality of the coxarthrosis, it is hypothesized that the inflammatory etiology of unilateral and bilateral osteoarthritis could have different dynamics. However, more in-depth studies with flow cytometry are needed to assess the possible impact of these differences in the inflammatory mechanisms observed in this study.

Introduction: In our country, hernioplasty for inguinocrural hernia is one of the most frequent surgical procedures, but there are scanty studies bring over of the long-term results. Materials and method: Observational retrospective cohort study, using clinical data base of patient's clinical history, in order to analyze the cause of reoperations on our inguinocrural hernioplasty data base, from the year 2000 to the year 2010, and with a follow up until June 2015. Results and discussion: In total they were performed 1,765 interventions coded crural and inguinal hernia, 100 cases required reoperation, 84 men and 16 women with an average age of 62 years for the first surgery. In a third hypertension was found, and in 38% of men, obstructive uropathy, not statistically significant (P=.6). Reoperation for contralateral hernia was performed in 38% of the cases, with predominant appearance within the first three years after the first surgery; in 37% of the cases, hernia recurrence was demonstrated. Patients, who recurred, were equivalent to 2.7% of all surgeries performed, but considering Lichtenstein technique, it was only 1.7% of all hernioplasties, occurring within the first three years. In 5 cases, we found double recurrence, and triple recurrence in two. Five patients had complications: two bruising, seroma, chronic inguinal pain and one death by postoperative intestinal obstruction. Conclusion: Our results were similar to those reported in our country in relation to the type of patients, comorbidities and recurrence at long-term, but with a lower rate of complications.

Introducción: En nuestro país la hernioplastia inguinocrural es una de las intervenciones quirúrgicas más frecuentes, pero hay escasos estudios acerca de los resultados a largo plazo. Materiales y método: Estudio observacional de cohorte retrospectiva utilizando base de datos, fichas clínicas y electrónicas, con el objeto de analizar las causas de reintervenciones en hernioplastias inguinocrurales desde el año 2000 hasta el 2010, con seguimiento hasta junio del 2015. Resultados y discusión: Se realizaron 1.765 intervenciones con los códigos de hernia inguinal y femoral, de los cuales 100 casos requirieron reintervención: 84 hombres y 16 mujeres, con edad promedio de 62 años para la primera cirugía. En un tercio se encontró HTA, y en el 38% de los hombres uropatía obstructiva, sin ser estadísticamente significativo (p = 0,6). Se demostró intervención por hernia contralateral en el 38% de los casos, con aparición predominante dentro de los 3 primeros años desde la primera cirugía; en el 37% se demostró recidiva herniaria. Los pacientes que recidivaron equivalen al 2,7% del total de cirugías realizadas, pero al considerar las recidivas solo con técnica de Lichtenstein, esta fue del 1,7% con respecto al total de hernioplastias realizadas, presentándose dentro de los 3 primeros años. En 5 casos se demostró doble recidiva y en 2 casos triple recidiva. Cinco pacientes presentaron complicaciones: 2 hematomas, un seroma, una inguinodinia crónica y un paciente falleció por obstrucción intestinal postoperatoria. Conclusión: Nuestros resultados son similares a casuísticas nacionales y metaanálisis reportados en cuanto a tipo de pacientes, comorbilidades asociadas y porcentaje de recidiva a largo plazo, con menor tasa de complicaciones.

OBJECTIVE: Ovarian mucinous metastases commonly present as the first sign of the disease and are capable of simulating primary tumors. Our aim was to investigate the role of intratumoral lymphatic vascular density together with other surgical-pathological features in distinguishing primary from secondary mucinous ovarian tumors. METHODS: A total of 124 cases of mucinous tumors in the ovary (63 primary and 61 metastatic) were compared according to their clinicopathological features and immunohistochemical profiles. The intratumoral lymphatic vascular density was quantified by counting the number of vessels stained by the D2-40 antibody. RESULTS: Metastases occurred in older patients and were associated with a higher proportion of tumors smaller than 10.0 cm; bilaterality; extensive necrosis; extraovarian extension; increased expression of cytokeratin 20, CDX2, CA19.9 and MUC2; and decreased expression of cytokeratin 7, CA125 and MUC5AC. The lymphatic vascular density was increased among primary tumors. However, after multivariate analysis, the best predictors of a secondary tumor were a size of 10.0 cm or less, bilaterality and cytokeratin 7 negativity. Lack of MUC2 expression was an important factor excluding metastasis. CONCLUSIONS: The higher intratumoral lymphatic vascular density in primary tumors when compared with secondary lesions suggests differences in the microenvironment. However, considering the differential diagnosis, the best discriminator of a secondary tumor is the combination of tumor size, laterality and the pattern of expression of cytokeratin 7 and MUC2.