RESUMO Objetivo: Avaliar a associação entre comportamentos modificáveis do estilo de vida e indicadores de saúde mental em adolescentes brasileiros. Métodos: Este estudo transversal utilizou dados da Pesquisa Nacional de Saúde do Escolar de 2019, incluindo 152.860 alunos. Comportamentos de estilo de vida e indicadores de saúde mental foram obtidos por meio de um questionário autoaplicável. Análises de regressão logística foram utilizadas para examinar a associação entre comportamentos de estilo de vida e indicadores de saúde mental. Resultados: Alimentação saudável infrequente (OR 1,22; IC95% 1,14–1,31), ser inativo (OR 1,82; IC95% 1,65–2,01), tabagismo (OR 1,24; IC95% 1,10–1,40) e frequência escolar inadequada (OR 1,31; IC95% 1,22–1,40) foram associados a não ter amigos próximos. Além disso, não ter amigos próximos também foi associado com alimentação não saudável (OR 0,86; IC95% 0,81–0,92) e consumo de álcool (OR 0,81; IC95% 0,75–0,87). Alimentação saudável infrequente (OR 1,29; IC95% 1,24–1,33), alimentação não saudável frequente (OR 1,39; IC95% 1,35–1,43), ser inativo (OR 1,12; IC95% 1,07–1,18), tempo excessivo em tela e sentado (OR 1,10; IC95% 1,07–1,14 e OR 1,68; IC95% 1,63–1,73, respectivamente), tabagismo (OR 1,26; IC95% 1,19–1,34), álcool (OR 1,33; IC95% 1,28–1,37), drogas (OR 1,13; IC95% 1,05–1,22) e frequência escolar irregular (OR 1,53; IC95% 1,48–1,59) foram associados a uma pior autopercepção de saúde mental. Conclusões: Vários comportamentos de estilo de vida foram associados a diferentes indicadores de saúde mental. Objetivo brasileiros Métodos 2019 152860 152 860 152.86 alunos autoaplicável Resultados 1,22 122 1 22 IC95 IC 1,14–1,31, 114131 1,14–1,31 , 14 31 1,14–1,31) 1,82 182 82 1,65–2,01, 165201 1,65–2,01 65 2 01 1,65–2,01) 1,24 124 24 1,10–1,40 110140 10 40 1,31 131 1,22–1,40 122140 disso 0,86 086 0 86 0,81–0,92 081092 81 92 0,81 081 0,75–0,87. 075087 0,75–0,87 . 75 87 0,75–0,87) 1,29 129 29 1,24–1,33, 124133 1,24–1,33 33 1,24–1,33) 1,39 139 39 1,35–1,43, 135143 1,35–1,43 35 43 1,35–1,43) 1,12 112 12 1,07–1,18, 107118 1,07–1,18 07 18 1,07–1,18) 1,10 110 107114 1,07–1,1 1,68 168 68 163173 63 73 1,63–1,73 respectivamente, respectivamente respectivamente) 1,26 126 26 1,19–1,34, 119134 1,19–1,34 19 34 1,19–1,34) 1,33 133 1,28–1,37, 128137 1,28–1,37 28 37 1,28–1,37) 1,13 113 13 1,05–1,22 105122 05 1,53 153 53 1,48–1,59 148159 48 59 Conclusões 201 15286 15 152.8 1,2 IC9 11413 1,14–1,3 3 1,8 8 16520 1,65–2,0 6 1,10–1,4 11014 4 1,3 1,22–1,4 12214 0,8 08 0,81–0,9 08109 9 07508 0,75–0,8 7 12413 1,24–1,3 13514 1,35–1,4 1,1 11 10711 1,07–1, 1,6 16 16317 1,63–1,7 11913 1,19–1,3 12813 1,28–1,3 1,05–1,2 10512 1,5 5 1,48–1,5 14815 20 1528 152. 1, 1141 1,14–1, 1652 1,65–2, 1,10–1, 1101 1,22–1, 1221 0, 0,81–0, 0810 0750 0,75–0, 1241 1,24–1, 1351 1,35–1, 1071 1,07–1 1631 1,63–1, 1191 1,19–1, 1281 1,28–1, 1,05–1, 1051 1,48–1, 1481 114 1,14–1 165 1,65–2 1,10–1 1,22–1 0,81–0 075 0,75–0 1,24–1 135 1,35–1 107 1,07– 163 1,63–1 119 1,19–1 128 1,28–1 1,05–1 105 1,48–1 148 1,14– 1,65– 1,10– 1,22– 0,81– 0,75– 1,24– 1,35– 1,07 1,63– 1,19– 1,28– 1,05– 1,48– 1,14 1,65 0,75 1,35 1,0 1,63 1,19 1,28 1,05 1,48 0,7 1,4

ABSTRACT Objective: To evaluate the association between modifiable lifestyle behaviors and mental health indicators in Brazilian adolescents. Methods: This cross-sectional study used data from the 2019 National Survey of School Health including 152,860 students. The lifestyle behaviors and mental health indicators were obtained from a self-reported questionnaire. Logistic regression analyses were used to examine the association between lifestyle behaviors and mental health indicators. Results: Infrequent healthy eating (OR 1.22; 95%CI 1.14–1.31), being inactive (OR 1.82; 95%CI 1.65–2.01), smoking (OR 1.24; 95%CI 1.10–1.40), and irregular school attendance (OR 1.31; 95%CI 1.22–1.40) were associated with not having close friends. Additionally, not having close friends was also associated with unhealthy eating (OR 0.86; 95%CI 0.81–0.92) and alcohol consumption (OR 0.81; 95%CI 0.75–0.87). Infrequent healthy eating (OR 1.29; 95%CI 1.24–1.33), frequent unhealthy eating (OR 1.39; 95%CI 1.35–1.43), being inactive (OR 1.12; 95%CI 1.07–1.18), excessive screen time and sitting (OR 1.10; 95%CI 1.07–1.14 and OR 1.68; 95%CI 1.63–1.73, respectively), smoking (OR 1.26; 95%CI 1.19–1.34), alcohol (OR 1.33; 95%CI 1.28–1.37), drugs (OR 1.13; 95%CI 1.05–1.22), and irregular school attendance (OR 1.53; 95%CI 1.48–1.59) were associated with worse self-rated mental health. Conclusions: Various lifestyle behaviors are associated with different indicators of mental health. Objective adolescents Methods crosssectional cross sectional 201 152860 152 860 152,86 students selfreported self reported questionnaire Results 1.22 122 1 22 95CI CI 95 1.14–1.31, 114131 1.14–1.31 , 14 31 1.14–1.31) 1.82 182 82 1.65–2.01, 165201 1.65–2.01 65 2 01 1.65–2.01) 1.24 124 24 1.10–1.40, 110140 1.10–1.40 10 40 1.10–1.40) 1.31 131 1.22–1.40 122140 Additionally 0.86 086 0 86 0.81–0.92 081092 81 92 0.81 081 0.75–0.87. 075087 0.75–0.87 . 75 87 0.75–0.87) 1.29 129 29 1.24–1.33, 124133 1.24–1.33 33 1.24–1.33) 1.39 139 39 1.35–1.43, 135143 1.35–1.43 35 43 1.35–1.43) 1.12 112 12 1.07–1.18, 107118 1.07–1.18 07 18 1.07–1.18) 1.10 110 107114 1.07–1.1 1.68 168 68 163173 63 73 1.63–1.73 respectively, respectively respectively) 1.26 126 26 1.19–1.34, 119134 1.19–1.34 19 34 1.19–1.34) 1.33 133 1.28–1.37, 128137 1.28–1.37 28 37 1.28–1.37) 1.13 113 13 1.05–1.22, 105122 1.05–1.22 05 1.05–1.22) 1.53 153 53 1.48–1.59 148159 48 59 selfrated rated Conclusions 20 15286 15 152,8 1.2 9 11413 1.14–1.3 3 1.8 8 16520 1.65–2.0 6 11014 1.10–1.4 4 1.3 1.22–1.4 12214 0.8 08 0.81–0.9 08109 07508 0.75–0.8 7 12413 1.24–1.3 13514 1.35–1.4 1.1 11 10711 1.07–1. 1.6 16 16317 1.63–1.7 11913 1.19–1.3 12813 1.28–1.3 10512 1.05–1.2 1.5 5 1.48–1.5 14815 1528 152, 1. 1141 1.14–1. 1652 1.65–2. 1101 1.10–1. 1.22–1. 1221 0. 0.81–0. 0810 0750 0.75–0. 1241 1.24–1. 1351 1.35–1. 1071 1.07–1 1631 1.63–1. 1191 1.19–1. 1281 1.28–1. 1051 1.05–1. 1.48–1. 1481 114 1.14–1 165 1.65–2 1.10–1 1.22–1 0.81–0 075 0.75–0 1.24–1 135 1.35–1 107 1.07– 163 1.63–1 119 1.19–1 128 1.28–1 105 1.05–1 1.48–1 148 1.14– 1.65– 1.10– 1.22– 0.81– 0.75– 1.24– 1.35– 1.07 1.63– 1.19– 1.28– 1.05– 1.48– 1.14 1.65 0.75 1.35 1.0 1.63 1.19 1.28 1.05 1.48 0.7 1.4

ABSTRACT Beans are a vital component of the human diet, being able to supply a large part of the daily protein requirements of individuals, in addition to containing considerable amounts of iron, calcium, vitamins, carbohydrates, fiber, and lysine. Controlled germination is an accessible and effective technique that aims to improve the nutritional, functional, and sensory qualities of seeds intended for food consumption. This study aimed to characterize fresh and germinated beans of Phaseolus vulgaris (carioca, branco, preto, gordo varieties) and Vigna unguiculata (cowpea). The germination process was conducted in trays containing the sand substrate (350 g) in the environmental conditions of the laboratory. The fresh and germinated beans were evaluated for physicochemical variables in triplicate. The germination process increased moisture content, water activity, ash, pH, soluble alcohol acidity, proteins, ascorbic acid, phenols, tannins, flavonoids, anthocyanins, and carotenoids. On the other hand, there was a reduction in the content of lipids, starch, and total sugars in bean seeds. With the increase in bioactive compounds, it was found that the germination process is an excellent method for increasing the nutritional quality of beans. diet individuals iron calcium vitamins carbohydrates fiber lysine functional consumption carioca, carioca (carioca branco preto varieties cowpea. cowpea . (cowpea) 350 (35 g laboratory triplicate activity ash pH acidity proteins acid phenols tannins flavonoids anthocyanins carotenoids hand lipids starch compounds (cowpea 35 (3 3 (

RESUMO O feijão é um importante componente da dieta humana, sendo capaz de suprir grande parte das necessidades proteicas diárias dos indivíduos, além de conter quantidades consideráveis de ferro, cálcio, vitaminas, carboidratos, fibras e lisina. A germinação controlada é uma técnica acessível e eficaz que visa melhorar as qualidades nutricionais, funcionais e sensoriais de sementes destinadas ao consumo alimentar. O objetivo deste estudo foi caracterizar feijão Phaseolus vulgaris das variedades carioca, branco, preto, gordo e feijão-caupi (Vigna unguiculata) in natura e germinado. O processo de germinação foi realizado em bandejas contendo substrato areia (350 g), em condições ambientais de laboratório. Em seguida, os grãos in natura e germinados foram avaliados quanto às variáveis físico-químicas em triplicata. A germinação do feijão aumentou o teor de umidade, atividade de água, cinzas, pH, acidez álcool solúvel, proteínas, ácido ascórbico, fenóis, taninos, flavonóides, antocianinas e carotenóides. Por outro lado, houve redução no teor de lipídios, amido e açúcares totais nas sementes de feijão. Com o aumento dos compostos bioativos, constatou-se que o processo de germinação é um excelente método para aumentar a qualidade nutricional do feijão. humana indivíduos ferro cálcio vitaminas carboidratos lisina nutricionais alimentar carioca branco preto feijãocaupi caupi Vigna unguiculata germinado 350 (35 g, g , g) laboratório seguida físicoquímicas físico químicas triplicata umidade água cinzas pH solúvel proteínas ascórbico fenóis taninos flavonóides carotenóides lado lipídios bioativos constatouse constatou se 35 (3 3 (

SUMMARY: Drinking alcohol while pregnant can cause several diseases, belonging to an umbrella of disorders known as Fetal Alcohol spectrum disorders. Alcohol exposure during pregnancy is linked to reduced birth weights, shorter bones, delayed bone growth, decreased bone resilience, and delayed ossification of the bones. However, the specific effects on the craniofacial bones, particularly the mandible, remain less explored. This study aims to fill this gap by examining the impact of gestational alcohol consumption on mandibular structure. Time-mated pregnant Sprague Dawley dams were divided into an ethanol group (n=6) and a saline control group (n=6). The ethanol group was given 0.015ml/g of 25.2% ethanol, while the control group received 0.9% saline for the first 19 days of gestation. The presence of a vaginal plug indicated the first day of gestation. After birth, the pups were euthanized at three weeks of age, and their mandibles were harvested and analyzed using a 3D-mCT scanner to assess bone ratio, trabecular thickness, number, and spacing. Osteometric measurements for mandibular length and height were also taken. The study found no significant differences in trabecular morphometric parameters between the groups. However, one parameter for mandibular length (Cd-Bi) and two parameters for mandibular height (Cd-Ag and Cr-Ag) were significantly smaller in the ethanol group than in the controls. The study reveals that gestational alcohol consumption can significantly affect the development of the mandible, with potential implications for understanding the mechanisms behind alcohol-induced teratogenicity. The findings highlight the need for further research to explore the intricate interactions between embryological, biological, genetic, and epigenetic factors that contribute to the varied effects of alcohol exposure during pregnancy on different skeletal systems.

RESUMEN: Beber alcohol durante el embarazo puede causar varias enfermedades, pertenecientes a un conjunto de trastornos conocidos como trastornos del espectro alcohólico fetal. La exposición al alcohol durante el embarazo está relacionada con un peso reducido al nacer, huesos más cortos, retraso en el crecimiento óseo, disminución de la resistencia ósea y retraso en la osificación de los huesos. Sin embargo, los efectos específicos sobre los huesos craneofaciales, particularmente la mandíbula, siguen siendo menos analizados. Este estudio tiene como objetivo llenar este vacío examinando el impacto del consumo de alcohol gestacional en la estructura mandibular. Las madres preñadas Sprague Dawley apareadas en el tiempo, se dividieron en un grupo de etanol (n=6) y un grupo control de solución salina (n=6). El grupo de etanol recibió 0,015 ml/g de etanol al 25,2 %, mientras que el grupo control recibió solución salina al 0,9 % durante los primeros 19 días de gestación. La presencia de un tapón vaginal indicó el primer día de gestación. Después del nacimiento, las crías fueron sacrificadas a las tres semanas de edad, y sus mandíbulas fueron extraídas y analizadas utilizando un escáner 3D-mCT para evaluar la proporción ósea, el grosor trabecular, el número y el espaciado. También se tomaron medidas osteométricas de longitud y altura mandibular. El estudio no encontró diferencias significativas en los parámetros morfométricos trabeculares entre los grupos. Sin embargo, un parámetro para la longitud mandibular (Cd-Bi) y dos parámetros para la altura mandibular (Cd-Ag y Cr-Ag) fueron significativamente menores en el grupo de etanol que en los controles. El estudio revela que el consumo de alcohol gestacional puede afectar significativamente el desarrollo de la mandíbula, con implicaciones potenciales para comprender los mecanismos detrás de la teratogenicidad inducida por el alcohol. Los hallazgos resaltan la necesidad de realizar más investigaciones para explorar las intrincadas interacciones entre factores embriológicos, biológicos, genéticos y epigenéticos que contribuyen a los diversos efectos de la exposición al alcohol durante el embarazo en diferentes sistemas esqueléticos.

Abstract Background and aims: Alcohol-attributable burdens of disease and social costs are a public health concern in Chile. Besides population-wide preventive policy, individual screening and brief counseling are effective ways to lower this burden. This study aims to estimate the national coverage and characteristics of healthcare provider-led alcohol quantity consumption screening (AQS) in Chile. Methods: The study included a random national household sample of 5,240 participants of the Chilean National Health Survey 2017. Estimates -in percentages with confidence intervals (CI)- were weighted by differences in selection probability and nonresponse rates. Logistic regressions were used to test differences between subgroups, adjusting by age, sex, area and region, adjusted for confounders. Results are shown as odds ratios (OR) with CI. Results: Last year, the national AQS prevalence was 30% (95% confidence interval (CI): 27.8-32.5), 31.6% (95% CI: 28.1-35.3), and 28.8% (95% CI: 25.7-31.9) for men and women respectively. The lowest prevalence was observed in 15 to 24 year old participants (25.1%, 95% CI: 19.8-31.1) and the highest (33%, 95% IC: 29.5-37.3) in the 45-64 year old population. Only age (odd rate (OR): 1.06, IC) and hepatotoxic drug use (OR: 1.45, IC) were associated to AQS in multivariable models. Conclusion: These results show that there are low rates of healthcare provider alcohol enquiry in the Chilean health system. Updated data and a more rigorous assessment of this subject are needed to aid in future public health policy design.

Resumen Antecedentes y objetivos: la carga de enfermedad y los costos asociados al consumo de alcohol son un problema de salud pública. Formas eficaces de combatir este problema son la detección individual y la consejería breve. El objetivo de este estudio es estimar y describir la cobertura nacional de consulta sobre consumo de alcohol (CCA) dirigida por profesionales de salud en Chile. Métodos: se incluyó una muestra nacional aleatoria de 5.240 participantes de la Encuesta Nacional de Salud de Chile 2017. Las estimaciones fueron ponderadas según diferencias en la probabilidad de selección y las tasas de falta de respuesta. Resultados expresados en porcentajes con intervalo de confianza (IC). Se realizaron regresiones logísticas univariadas por edad, sexo, zona y región, ajustadas por confundentes. Resultado expresado en odds ratio (OR) junto con IC. Resultados: la prevalencia nacional de CCA fue de 30% (IC 95 %: 27,8-32,5), y de 31,6 % (IC 95 %: 28,1-35,3) y 28,8 % (IC 95%: 25,7-31,9) para hombres y mujeres respectivamente. La prevalencia más baja fue en participantes de 15 a 24 años (25,1%, IC 95%: 19,8-31,1) y la más alta (33%, IC 95%: 29,5-37,3) en la población de 45 a 64 años. En los modelos de regresión, la edad (OR: 1,06; IC 95% 1,00-1,11, por diez años de aumento en la edad) y el uso de drogas hepatotóxicas (OR: 1,45; IC 95%: 1,10-1,90), fueron las únicas variables que se asociaron significativamente con mayor CCA. Conclusión: este estudio encontró bajos porcentajes de CCA en Chile. Hace falta estudiar a mayor profundidad esta problemática para la mejoría o generación de nuevas políticas.

Resumen La presión arterial media es un indicador indirecto del grado de perfusión orgánica, la cual podría variar en pacientes con y sin diabetes mellitus-2. El objetivo fue determinar las diferencias y riesgo de alteraciones en la presión arterial media de adultos con y sin diabetes mellitus-2 de la población peruana según datos de la encuesta demográfica de salud familiar. Se realizó un estudio observacional, analítico, retrospectivo y transversal;. Los datos provinieron de la encuesta demográfica y de salud familiar-2022 (ENDES-2022), se incluyó adultos diabéticos y no diabéticos. Las variables fueron: presión arterial media, diabetes mellitus-2, sexo y se incluyeron las variables: edad, consumo de alcohol, nivel educativo e índice de masa corporal para el análisis multivariado. Se realizó la prueba de Chi-cuadrado de Pearson, la prueba T student para muestras independientes, Odds Ratio crudo y ajustado mediante regresión logística binaria. El promedio de presión arterial media en diabéticos fue de 94,81 y 93,52 mmHg en la primera y segunda medición y en no diabéticos de 89,18 y 88,02 mmHg. La presión arterial media alta fue más frecuente en diabéticos que en no diabéticos; En el modelo logístico, incluyendo las variables sexo y edad, los diabéticos tuvieron un riesgo 2 veces mayor que los no diabéticos de alteraciones en la presión arterial media tanto en la primera como en la segunda medición. En conclusión, la diabetes mellitus-2 incrementa la presión arterial media y representa un factor de riesgo para la elevación de la presión arterial media en la población peruana.

Abstract Mean arterial pressure is an indirect indicator of the degree of organ perfusion, which could vary in diabetics and non-diabetics. The objective of this research was to determine the differences and risk of alterations in the mean arterial pressure of adults with and without diabetes mellitus-2 of the Peruvian population according to data from the family health demographic survey. An observational, analytical, retrospective and cross-sectional study was carried out. The data came from the demographic and family health survey-2022 (ENDES-2022). Diabetic and non-diabetic adults were included. The variables were mean arterial pressure, diabetes mellitus-2, sex, and the variables age, alcohol consumption, educational level, and body mass index were included for multivariate analysis. Pearson's Chi-square test, student's T test for independent samples, crude Odds Ratio and adjusted by binary logistic regression were performed. The mean arterial pressure in diabetics was 94.81 and 93.52 mmHg in the first and second measurements, and in non-diabetics it was 89.18 and 88.02 mmHg. High mean arterial pressure was more frequent in diabetics than in non-diabetics. In the logistic model, including the variables sex and age, diabetics had a risk twice as high as non-diabetics for alterations in mean arterial pressure in both the first and second measurements. In conclusion, diabetes mellitus-2 increases mean arterial pressure and represents a risk factor for elevated mean arterial pressure in the Peruvian population.

RESUMEN: El consumo de alcohol entre menores de edad se ha convertido en una importante preocupación pública que tiene un impacto negativo en el crecimiento y desarrollo del esqueleto. La masa ósea máxima se alcanza durante la adolescencia, por lo que el objetivo del estudio fue investigar el efecto del consumo excesivo de alcohol en forma aguda sobre la morfometría trabecular y la resistencia a la tracción de la mandíbula en ratas adolescente Sprague Dawley (SD). El estudio estuvo compuesto por 24 ratas, de 7 semanas de edad, colocadas en el grupo control expuesto al alcohol [n=12 (6 machos y 6 hembras)] y alimentado en parejas [n=12 (6 machos y 6 hembras)]. El tratamiento de los grupos fue el siguiente; al grupo expuesto al alcohol y al control alimentado en parejas se les administró una dosis única diaria de 3 g/kg de alcohol al 20 % 3 días a la semana (días alternos) durante 7 días y una dosis equivalente calórica de maltosa dextrina mediante sonda oral, respectivamente. Los animales fueron sacrificados el día 7 mediante inyección de pentobarbital. Las mandíbulas se recolectaron y se escanearon utilizando un escáner 3D-microCT Nikon XTH 255L (Nikon Metrology, Lovaina, Bélgica), y las pruebas biomecánicas se realizaron utilizando una máquina de prueba de resistencia a la tracción universal Shimadzu (China). Después del escaneo y la reconstrucción, la morfometría trabecular se evaluó utilizando el software Volume Graphics Studio®. Se utilizó una prueba de flexión de 3 puntos para evaluar la resistencia a la tracción del hueso. Los hallazgos de nuestro estudio mostraron cambios en algunos parámetros trabeculares en el grupo de hembras expuestas al alcohol, mientras que los grupos de machos no se vieron afectados. No se observaron cambios en la resistencia a la tracción al comparar los grupos control de machos alimentados en parejas y los grupos expuestos al alcohol y al comparar los grupos control de las hembras alimentadas en parejas y los grupos expuestos al alcohol. Se observaron diferencias trabeculares y de resistencia a la tracción entre los sexos al comparar los grupos control de los machos alimentados en parejas y expuestos al alcohol con los grupos de control de hembras alimentadas en parejas y expuestas al alcohol. Estos hallazgos sugieren que el consumo excesivo de alcohol tiene efectos perjudiciales sobre la microarquitectura ósea en ratas hembras expuestas al alcohol y que se observan diferencias entre los sexos.

SUMMARY: Underage drinking has become a major public concern having a negative impact on the growth and development of the skeleton. Peak bone mass is attained during adolescence hence the aim of the study was to investigate the effect of acute binge alcohol consumption on trabecular morphometry and tensile strength of the adolescent mandible in the Sprague Dawley (SD) rat. The study comprised of 24 SD rats, aged 7 weeks, placed into either the alcohol-exposed [n=12 (6 males and 6 female)] or pair-fed control group [n=12 (6 male and 6 female)]. The treatment of the groups was as follows; the alcohol exposed group and the pair-fed control were administered a single daily dose of 3 g/kg of 20 % alcohol 3 days a week (alternate days) for 7 days and a caloric equivalent dose of maltose dextrin via oral gavage, respectively. The animals were terminated on day 7 via pentobarbital injection. The mandibles were harvested and scanned using a Nikon XTH 255L 3D-microCT scanner (Nikon Metrology, Leuven, Belgium), and biomechanical tests were done using a Shimadzu universal tensile strength testing machine (China). Following scanning and reconstruction, the trabecular morphometry was assessed using Volume Graphics Studio® software. A 3-point bending test was used to evaluate the tensile strength of the bone. Findings from our study showed changes in some trabecular parameters in the female alcohol-exposed group, while the male groups remained unaffected. No changes in tensile strength were seen when comparing male pair-fed control and alcohol-exposed groups and when comparing female pair-fed control and alcohol-exposed groups. Trabecular and tensile strength differences were observed between the sexes when comparing male pair-fed control and alcohol-exposed groups to female pair-fed control and alcohol-exposed groups. These findings do suggest that acute binge alcohol consumption has detrimental effects on the bone micro-architecture in female alcohol-exposed rats and that differences are seen between the sexes.

Abstract Objective: To describe the changes in alcohol and drug use by Brazilian adolescents during the COVID-19 pandemic (April-August 2021), and to analyze the relationship between alcohol use changes and psychiatric symptomatology. Methods: A secondary analysis with a longitudinal approach was performed with data from a cluster-randomized controlled trial, conductedin73publicmiddleschoolsinthreeBrazilian cities, to evaluate the effectiveness of a drug use prevention program. The sample included 535 students (61% girls; Mage = 15.2 years). Data were collected pre-intervention (February-March 2019), after 9 months (November-December 2019), and after 26 months (April-August 2021), when the students were in their first year of high school. The authors analyzed drug use prevalence (alcohol, binge drinking, tobacco, inhalants, marijuana, cocaine, and crack) in a lifetime, past year, and past month periods, and the association between alcohol use change subsamples with psychiatric symptoms. Logistic regressions were adjusted by sex, age, socioeconomic status, city, and group (control and intervention). Results: The present findings suggest that the COVID-19 pandemic led to a decrease in past-year substance use and in past-month substance use frequency, despite the gradually increased (but decelerating) prevalence of lifetime use. However, some adolescents initiated, maintained, or increased the frequency of their alcohol use. Mainly, they were more likely to present behavioral problems, as well as symptoms of inattentive hyperactivity, and peer and emotional problems. Conclusions: Despite the extensive decline in substance use during the pandemic period, these results suggest an association between previous mental health conditions and behavioral risk factors, leading to increased alcohol consumption and behavioral disorders manifestations. Objective COVID19 COVID 19 COVID-1 AprilAugust April August 2021, 2021 , 2021) symptomatology Methods clusterrandomized cluster randomized trial conductedinpublicmiddleschoolsinthreeBrazilian conductedin publicmiddleschoolsinthreeBrazilian cities program 53 61% 61 (61 girls 152 15 2 15. years. years . years) preintervention pre intervention FebruaryMarch February March 2019, 2019 2019) NovemberDecember November December school alcohol, (alcohol drinking tobacco inhalants marijuana cocaine crack periods sex age status city control intervention. intervention) Results pastyear pastmonth but decelerating However initiated maintained Mainly problems hyperactivity Conclusions period factors manifestations COVID1 1 COVID- 202 5 6 (6 201 20 (

Resumen El consumo de sustancias psicoactivas (SPA) trae efectos de adicción que modifican el pensamiento, la mente y el espíritu del adicto, no solo está generando un riesgo latente que afecta la salud de las personas, también trae consecuencias negativas para la sociedad misma, como mayor inversión económica en salud, presencia de habitantes de calle, aumento de delincuencia, entre otros aspectos. El objetivo del presente estudio consistió en evaluar las estadísticas relacionadas con el consumo de sustancias psicoactivas a nivel mundial en las últimas tres décadas. Para el análisis de la información se utilizó la técnica multivariada de la varianza MANOVA con contraste canónica ortogonal, se empleó el paquete estadístico SAS University en el proceso de la información. Como resultado destacado, se encontró divergencia estadística entre regiones, donde Norteamérica ocupa el primer lugar seguido de Asia y Oceanía. El mayor número de muertes por trastornos relacionados por el consumo de SPA se da en personas menores a los 49 años. El acelerado incremento y abuso en el consumo de SPA está generando altos índices de morbilidad y mortalidad a nivel global. Es una prioridad actuar con urgencia desde todos los frentes, profesionales de la salud, líderes políticos y comunitarios, entes educativos y núcleo familiar, para controlar esta problemática y tratar de disminuir el consumo y abuso de SPA.

Abstract The consumption of psychoactive substances (PAS) has addictive effects that modify the addict's thinking, mind and spirit, and not only generates a latent risk that affects people's health, but also has negative consequences for society itself, such as greater economic investment in health, the presence of street dwellers, and an increase in crime, among other aspects. The objective of this study was to evaluate the statistics related to the consumption of psychoactive substances worldwide in the last three decades. For the analysis of the information, the multivariate technique of variance MANOVA with orthogonal canonical contrast was used, and the SAS University statistical package was used to process the information. As an outstanding result, statistical divergence was found between regions, with North America occupying the first place followed by Asia and Oceania. The highest number of deaths due to disorders related to PAS consumption occurs in people under 49 years of age. The accelerated increase and abuse of PAS is generating high rates of morbidity and mortality globally. It is a priority to act urgently from all fronts, health professionals, political and community leaders, educational entities and the family nucleus, to control this problem and try to reduce the consumption and abuse of PAS.

Abstract: Introduction: The increasing acceptance of cannabinoids for therapeutic purposes has been linked to changes in legislation, high prevalence and ineffective control of chronic pain with conventional analgesics. Objective: Determine the prevalence of chronic pain, the analgesic treatment modality with herbal therapies (cannabis) in adults in southeastern Mexico. Material and methods: A cross-sectional and ethnographic study was carried out on 267 people with chronic pain and regular use of herbal medicine for analgesic purposes. Hypothesis tests were carried out to evaluate differences between average values, age and pain intensity, comparing the use of cannabis with the type of pain, gender, algological diagnoses and comorbidities. Results: An association was observed between chronic pain: diabetes, hypertension, neoplasms in women, in older adults. 46% of the participants suffered from osteoarthritis and 20.9% had other diagnoses. The preferred modality for the topical administration of cannabis was tinctures in Mezcal or alcohol and to a lesser extent macerated in oils and inhalation. Conclusions: The findings do not allow cannabis to be considered as monotherapy for chronic pain in patients with chronic pain. However, they offer a promising field in the search for analgesic alternatives that avoid the chronic consumption of opiates or non-steroidal anti-inflammatory drugs (NSAIDs).

Resumen: Introducción: La creciente aceptación de los cannabinoides con fines terapéuticos se ha vinculado a cambios en la legislación, alta prevalencia y control ineficaz de dolor crónico con analgésicos convencionales. Objetivo: Determinar la prevalencia del dolor crónico, la modalidad de tratamiento analgésico con terapias herbales (cannabis) en adultos del sureste de México. Material y métodos: Se efectuó un estudio transversal y etnográfico en 267 personas con dolor crónico y empleo regular de la herbolaria con fines analgésicos. Se efectuaron pruebas de hipótesis para evaluar diferencias entre valores promedio, edad e intensidad del dolor, comparándose el empleo de cannabis con el tipo de dolor, género, diagnósticos algológicos y comorbilidades. Resultados: Se observó asociación entre dolor crónico con: diabetes, hipertensión, neoplasias en mujeres, adultos mayores. El 46% de los participantes padecía osteoartritis y 20.9% presentaba otros diagnósticos. Las modalidades preferidas para la administración tópica de cannabis fueron tinturas en mezcal o en alcohol y, en menor proporción, macerados en aceites e inhalación. Conclusiones: Los hallazgos no permiten considerar a la cannabis como monoterapia para pacientes con dolor crónico. Sin embargo, ofrecen un campo promisorio en la búsqueda de alternativas analgésicas que eviten el consumo crónico de opiáceos o antiinflamatorios no esteroideos (AINE).

ABSTRACT The objective of this work is to compare the quality of life of precarious quarry and brick-kiln workers in the municipality of San Luis Potosí and artisanal mercury mining in Camargo, Querétaro. Field work and non-participatory observation were carried out. During the field research period in 2019-2020, a questionnaire was applied to a total of 118 workers. The data were organized and processed with the Excel program (Microsoft Office 365) and analyzed within the framework of environmental anthropology and everyday-life approaches. In both contexts, it was found that the workers present a high level of marginalization, chronic diseases, physical inactivity, alcohol and tobacco consumption, in addition to the lack of protective equipment. According to the activity performed, they suffer from different occupational hazards. Furthermore, they are not employed under a labor contract, and their families also participate in the work. The identified situations of occupational precariousness presented various diagnosed chronic degenerative comorbidities, lack of protective equipment to perform their activities, occupational hazards and little access to health services. Therefore, multidisciplinary efforts and approaches are required to assess, address and draw attention to their conditions, in order to prevent, intervene and transform labor precariousness into decent work. Rev Arg Antrop Biol 26 (1), 2024. https://doi.org/10.24215/18536387e072

RESUMEN Este objetivo de este trabajo es comparar la calidad de vida de los trabajos precarios de cantera y ladrillo del municipio de San Luis Potosí y minería artesanal de mercurio en Camargo, Querétaro. Se realizó trabajo de campo y observación no participativa. Durante el periodo de investigación de campo en 2019-2020 se aplicó un cuestionario a un total de 118 trabajadores. Los datos fueron organizados y tratados con el programa Excel (versión Microsoft Office 365) y analizados dentro del marco de los enfoques de la antropología ambiental y de la vida cotidiana. En ambos contextos, se encontró que los trabajadores presentan un nivel alto de marginación, enfermedades crónicas, inactividad física, consumo de alcohol y tabaco, además de que no cuentan con equipo de protección, de acuerdo con la ocupación, tienen diferentes riesgos laborales. Además, no cuentan con contrato laboral. Aunado a ello, la familia participa en las labores. Los escenarios de precariedad laboral identificados presentaron algunas comorbilidades crónico-degenerativas diagnosticadas, nulo equipo de protección para realizar sus actividades, riesgos laborales y poco acceso a servicios de salud. Por lo tanto, requieren de esfuerzos y abordajes multidisciplinarios que permitan evaluar, atender y visibilizar sus condiciones con la finalidad de prevenir, intervenir y transformar la precariedad laboral en trabajo decente. Rev Arg Antrop Biol 26 (1), 2024. https://doi.org/10.24215/18536387e072

Abstract Introduction: Alcohol consumption is a complex social practice that plays a role in building and consolidating friendships, as well as creating gender identities. The latter determines the limits of behaviors and defines what is considered appropriate or inappropriate in our daily routine; therefore, alcohol consumption patterns are not independent of gender. Objective: To identify and describe available evidence on the influence of gender on youth alcohol consumption. Materials and method: A review was conducted under JBI and Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Extension for Scoping Reviews (PRISMA-ScR) guidelines. Original full-text articles published between 2018 and 2023 in the VHL, PubMed, EBSCOhost, Web of Sciences, Epistemonikos, ScienceDirect, and ProQuest databases, without language limitations, were analyzed. The search categories were "Alcohol Drinking" AND "Young Adult" AND "Gender Identity" OR "Gender role". Results: A total of 403 records were identified, but only 12 studies were included in the synthesis. The main results of these studies showed that both gender identity and gender roles influence alcohol consumption in young adults. Social gender norms may pressure young women to maintain a physical image and young men to maintain a normative public image. Conclusions: Social gender norms influence alcohol consumption behaviors; therefore, it is necessary to take these gender differences into account in nursing interventions and prevention strategies.

Resumen Introducción: El consumo de alcohol es una práctica social compleja que desempeña un papel en la construcción y consolidación de amistades, así como en la formación de identidades de género. Este último determina los límites de los comportamientos y define lo que se considera apropiado o inapropiado en nuestra rutina diaria; por lo tanto, los patrones de consumo de alcohol no son independientes del género. Objetivo: Identificar y describir la evidencia disponible sobre la influencia del género en el consumo de alcohol de los jóvenes. Materiales y método: Se realizó una revisión bajo las pautas del Instituto Joanna Briggs (JBI) y los lineamientos del Preferred Reporting Items for Systematic reviews and Meta-Analyses, Extension for Scoping Reviews (PRISMA-ScR). Se analizaron artículos originales a texto completo, publicados entre 2018 y 2023 en las bases BVS, PubMed, EBSCOhost, Web of Sciences, Epistemonikos, ScienceDirect, y ProQuest, sin limitación de idioma; las categorías de búsqueda fueron "Alcohol Drinking" AND "Young Adult" AND "Gender Identity" OR "Gender role". Resultados: Se identificaron 403 registros, pero solo se incluyeron 12 estudios en la síntesis. Los resultados principales de estos estudios mostraron que tanto la identidad de género como los roles de género influyen en el consumo de alcohol en adultos jóvenes. Las normas sociales de género pueden presionar a las mujeres jóvenes a mantener una imagen física y a los hombres jóvenes a mantener una imagen pública normativa. Conclusiones: Las normas sociales de género influyen en los comportamientos de consumo de alcohol, por ello, es necesario tener en cuenta estas diferencias de género en las intervenciones de enfermería y estrategias de prevención.

Resumo Introdução: O consumo de bebida alcoólica é uma prática social complexa que desempenha um papel na construção e na consolidação de amizades, bem como na formação de identidades de gênero. Este último determina os limites dos comportamentos e define o que é considerado apropriado ou inapropriado em nossas rotinas diárias; portanto, os padrões de consumo de álcool não são independentes do gênero. Objetivo: Identificar e descrever as evidências disponíveis sobre a influência do gênero no consumo de álcool pelos jovens. Materiais e métodos: Foi realizada uma revisão de acordo com as diretrizes do Joanna Briggs Institute (JBI) e dos lineamentos do Preferred Reporting Items for Systematic Reviews and Meta-Analyses, Extension for Scoping Reviews (PRISMA-ScR). Foram analisados artigos originais de texto completo, publicados entre 2018 e 2023 nos bancos de dados BVS, PubMed, EBSCOhost, Web of Sciences, Epistemonikos, ScienceDirect e ProQuest, sem limitação de idioma; as categorias de pesquisa foram "alcohol drinking" AND "young adult" AND "gender identity" OR "gender role". Resultados: Foram identificados 403 registros, mas apenas 12 estudos foram incluídos na síntese. Os principais resultados desses estudos mostraram que tanto a identidade de gênero quanto as funções de gênero influenciam o consumo de bebida alcoólica por jovens adultos. As normas sociais de gênero podem pressionar as mulheres jovens a manter uma imagem física e os homens jovens a manter uma imagem pública normativa. Conclusões: As normas sociais de gênero influenciam os comportamentos de consumo de álcool; portanto, essas diferenças de gênero precisam ser levadas em conta nas intervenções de enfermagem e nas estratégias de prevenção.

Resumen Objetivo: comprobar si el seguimiento telefónico agrega efecto a la aplicación de Intervenciones Breves para el uso de alcohol entre las mujeres embarazadas. Metodología: se trata de un ensayo clínico controlado y aleatorizado, abierto, paralelo, de dos brazos. Los datos fueron recolectados en la atención primaria de salud en São Carlos y el Centro de Referencia para la Salud de la Mujer en Ibaté (São Paulo, Brasil). Se realizó un seguimiento de las mujeres embarazadas que consumieron cualquier cantidad de alcohol durante el embarazo. Posteriormente, fueron distribuidos aleatoriamente en dos grupos. El grupo de control recibió solo una breve intervención; el grupo experimental recibió una intervención breve y fue monitoreado semanalmente por teléfono durante dos semanas después de la intervención. Se utilizó un programa estadístico para realizar estadísticas descriptivas e inferenciales (Test de Wilcoxon). Resultados: Hubo una reducción en el consumo en ambos grupos. Sin embargo, solo en el grupo experimental en el que se implementó la intervención con seguimiento, hubo abstinencia en todo el grupo (AUDIT-C: p-valor=0,011; T-ACE: p-valor=0,010). Conclusiones: Las intervenciones breves asociadas al seguimiento telefónico durante el embarazo demostraron ser efectivas para detener el consumo de alcohol. El seguimiento continuo después de intervenciones breves mejora las tasas de abstinencia de alcohol. Registro Brasileño de Ensayos Clínicos: RBR-4y4k7w.

Abstract Objective: to test whether telephone monitoring adds effect to the application of Brief Interventions for alcohol use among pregnant women. Methodology: this is a controlled and randomized clinical trial, open, parallel, with two arms. Data were collected in primary health care in São Carlos and Reference Center for Women's Health in Ibaté (São Paulo, Brazil). Pregnant women who consumed any amount of alcohol during pregnancy were tracked. Afterwards, they were randomly allocated into two groups. The control group received only a brief intervention; the experimental group received a brief intervention and were monitored weekly by telephone for two weeks after the intervention. A statistical program was used to perform descriptive and inferential statistics (Wilcoxon Test). Results: There was a reduction in consumption in both groups. However, only in the experimental group in which the intervention with monitoring was implemented, there was abstinence in the entire group (AUDIT-C: p-value=0.011; T-ACE: p-value=0.010). Conclusions: Brief interventions associated with telephone monitoring during pregnancy proved to be effective in stopping alcohol consumption. Continuous monitoring after brief interventions improves alcohol abstinence rates. Brazilian Registry of Clinical Trials: RBR-4y4k7w.

Resumo Objetivo: testar se o monitoramento por telefone acrescenta efeito à aplicação de Intervenções Breves para o uso de álcool entre gestantes. Metodologia: trata-se de ensaio clínico controlado e randomizado, aberto, paralelo, com dois braços. Os dados foram coletados na atenção primária à saúde de São Carlos e Centro de Referência de Saúde da Mulher em Ibaté (São Paulo, Brasil). Foram rastreadas gestantes que consumiram qualquer quantidade de álcool na gestação. Após, foram alocadas aleatoriamente em dois grupos. O grupo controle recebeu apenas uma intervenção breve; o grupo experimental recebeu uma intervenção breve e foi monitorado semanalmente por telefone nas duas semanas posteriores à intervenção. Utilizou-se programa estatístico para realização de estatísticas descritivas e inferencial (Teste de Wilcoxon). Resultados: Houve redução do consumo nos dois grupos. Porém, apenas no grupo experimental em que foi implementado intervenção com monitoramento, houve abstinência de todo o grupo (AUDIT-C: p-valor=0,011; T-ACE: p-valor=0,010). Conclusões: Intervenções breves associadas a monitoramento telefônico durante a gestação se mostraram efetivas para a cessação do consumo de álcool. O monitoramento contínuo após intervenções breves melhora as taxas de abstinência de álcool. Registro Brasileiro de Ensaios Clínicos: RBR-4y4k7w.

ABSTRACT The COVID-19 pandemic has reduced access to food and increased food insecurity. The objectives were to analyse the prevalence of Food and Nutritional Insecurity (FNI) in Brazilian adolescents during the COVID-19 pandemic according to sociodemographic characteristics and to examine the association between FNI and risk and protective behaviours in Brazilian adolescents during the that period. Cross-sectional study with data from the ‘ConVid teenagers – Behaviour Survey,’ carried out between June and October 2020, using a self-administered questionnaire via mobile phone or computer. The population was made up of teenagers aged 12 to 17, totalling 9,470. The Prevalence Ratio (PR) and 95% Confidence Interval (95% CI) were used, using Poisson regression with robust variance. The prevalence of FNI (26.1%) was higher among adolescents of black and mixed race/colour and who study in public schools. Adolescents who reported FNI had lower consumption of vegetables and fruits, less physical activity, and greater use of cigarettes and alcohol. FNI was more prevalent in adolescents with worse socioeconomic conditions, and adolescents with FNI showed a higher frequency of health risk behaviours, highlighting the importance of intersectoral public policies to reduce inequalities. COVID19 COVID 19 COVID-1 insecurity (FNI period Crosssectional Cross sectional ConVid Survey, Survey 2020 selfadministered self administered computer 1 17 9470 9 470 9,470 PR (PR 95 (95 CI used variance 26.1% 261 26 (26.1% racecolour race colour schools fruits activity alcohol conditions inequalities COVID1 COVID- 202 947 47 9,47 (9 26.1 2 (26.1 20 94 4 9,4 ( 26. (26. 9, (26 (2

RESUMO A pandemia de covid-19 reduziu o acesso aos alimentos e aumentou a insegurança alimentar. Objetivouse analisar a prevalência de Insegurança Alimentar e Nutricional (IAN) em adolescentes brasileiros durante a pandemia de covid-19 segundo características sociodemográficas e examinar a associação entre IAN e comportamentos de risco e proteção em adolescentes brasileiros durante esse período. Estudo transversal com dados da ‘ConVid Adolescentes – Pesquisa de Comportamentos’, realizada entre junho e outubro de 2020, utilizando-se um questionário autoaplicado por meio de celular ou computador. A população foi adolescentes de 12 a 17 anos, totalizando 9.470. Utilizou-se a Razão de Prevalência (RP) e Intervalo de Confiança de 95% (IC95%), por meio da regressão de Poisson com variância robusta. A prevalência de IAN (26,1%) foi mais elevada entre os adolescentes da raça/cor preta e parda e que estudam em escola pública. Os adolescentes que relataram IAN tiveram menor consumo de hortaliças e frutas, menor prática de atividade física e maior uso de cigarros e álcool. A IAN foi mais prevalente em adolescentes com piores condições socioeconômicas, e, adolescentes com IAN apresentaram maior frequência de comportamentos de risco para a saúde evidenciando a importância de políticas públicas intersetoriais para a redução de desigualdades. covid19 covid 19 covid-1 alimentar (IAN período ConVid Comportamentos, Comportamentos , Comportamentos’ 2020 utilizandose utilizando se computador 1 anos 9470 9 470 9.470 Utilizouse Utilizou RP (RP 95 IC95%, IC95 IC IC95% (IC95%) robusta 26,1% 261 26 (26,1% raçacor raça cor pública frutas álcool socioeconômicas desigualdades covid1 covid- 202 947 47 9.47 IC9 (IC95% 26,1 2 (26,1 20 94 4 9.4 (IC95 26, (26, 9. (IC9 (26 (IC (2 (

ABSTRACT The COVID-19 pandemic has reduced access to food and increased food insecurity. The objectives were to analyse the prevalence of Food and Nutritional Insecurity (FNI) in Brazilian adolescents during the COVID-19 pandemic according to sociodemographic characteristics and to examine the association between FNI and risk and protective behaviours in Brazilian adolescents during the that period. Cross-sectional study with data from the ‘ConVid teenagers – Behaviour Survey,’ carried out between June and October 2020, using a self-administered questionnaire via mobile phone or computer. The population was made up of teenagers aged 12 to 17, totalling 9,470. The Prevalence Ratio (PR) and 95% Confidence Interval (95% CI) were used, using Poisson regression with robust variance. The prevalence of FNI (26.1%) was higher among adolescents of black and mixed race/colour and who study in public schools. Adolescents who reported FNI had lower consumption of vegetables and fruits, less physical activity, and greater use of cigarettes and alcohol. FNI was more prevalent in adolescents with worse socioeconomic conditions, and adolescents with FNI showed a higher frequency of health risk behaviours, highlighting the importance of intersectoral public policies to reduce inequalities.

RESUMO A pandemia de covid-19 reduziu o acesso aos alimentos e aumentou a insegurança alimentar. Objetivouse analisar a prevalência de Insegurança Alimentar e Nutricional (IAN) em adolescentes brasileiros durante a pandemia de covid-19 segundo características sociodemográficas e examinar a associação entre IAN e comportamentos de risco e proteção em adolescentes brasileiros durante esse período. Estudo transversal com dados da ‘ConVid Adolescentes – Pesquisa de Comportamentos’, realizada entre junho e outubro de 2020, utilizando-se um questionário autoaplicado por meio de celular ou computador. A população foi adolescentes de 12 a 17 anos, totalizando 9.470. Utilizou-se a Razão de Prevalência (RP) e Intervalo de Confiança de 95% (IC95%), por meio da regressão de Poisson com variância robusta. A prevalência de IAN (26,1%) foi mais elevada entre os adolescentes da raça/cor preta e parda e que estudam em escola pública. Os adolescentes que relataram IAN tiveram menor consumo de hortaliças e frutas, menor prática de atividade física e maior uso de cigarros e álcool. A IAN foi mais prevalente em adolescentes com piores condições socioeconômicas, e, adolescentes com IAN apresentaram maior frequência de comportamentos de risco para a saúde evidenciando a importância de políticas públicas intersetoriais para a redução de desigualdades.

ABSTRACT Introduction: Different parameters of suicide attempts treated since the implementation of the Attention to Suicide Risk Program (ARSUIC) in 2012 at the Hospital Ramón y Cajal in Madrid Region are described in this paper. Method: The sample was composed of 107 patients and the information was collected through a questionnaire created ad hoc with the following variables: type of suicidal ideation; drug use immediately prior to the attempt; method (in case of drug overdosing: drug/s used); location; accessibility to rescue; planning; intentionality; criticism; and brakes. Results: Descriptive statistics were obtained and a comparison by gender was made through the x2 and contingency coefficients tests. The data from the retrospective longitudinal study showed that the most common profile was of patients with unstructured ideas of death and no previous drug use who took an unplanned drug overdose in the family home, with the intention of self-harm or avoidance of discomfort, especially with benzodiazepines. Patients tend to ask for help afterwards and criticise the attempt, but potential restraints are often not recorded in the clinical report. Regarding the dissimilarities based on gender, statistically significant differences were found in prior alcohol consumption, in favour of men and in the overdose method, specifically with benzodiazepines, in favour of women. Conclusions: Knowing the types of attempts at self-harm is essential for improving prevention, understanding and patient management.

RESUMEN Introducción: En el presente trabajo se describen distintos parámetros de las tentativas de suicidio atendidas desde la implementación del programa de Atención al Riesgo Suicida (ARSUIC) en 2012 en el Hospital Ramón y Cajal de la Comunidad de Madrid, España. Métodos: La muestra estuvo compuesta por 107 pacientes y la información se recogió a través de un cuestionario creado ad hoc con las siguientes variables: tipo de ideación suicida, consumo de tóxicos inmediatamente antes, método (en caso de sobreingesta medicamentosa: fármaco/s utilizado/s), ubicación, accesibilidad al rescate, planificación, intencionalidad, crítica y frenadores. Resultados: Se obtuvieron estadísticos descriptivos y se realizó una comparación por sexo a través de las pruebas de x2 y coeficientes de contingencia. Los datos del estudio longitudinal retrospectivo mostraron como perfil más frecuente el de pacientes con ideas de muerte no estructuradas, sin consumo previo de tóxicos, que se realizan en el domicilio familiar de manera no planificada y con intención autolítica o evitativa del malestar de una sobreingesta medicamentosa, especialmente con benzodiacepinas. Los pacientes tienden a solicitar auxilio posterior y realizar crítica del intento, y los potenciales frenadores con frecuencia no se recogen en el informe clínico. Respecto a las disimilitudes en función del sexo, se encontraron diferencias estadísticamente significativas en el consumo previo de alcohol, a favor de los hombres, y en el método sobreingesta, concretamente con benzodiacepinas, a favor de las mujeres. Conclusiones: Profundizar en las tipologías de los intentos autolíticos resulta fundamental para mejorar la prevención, la comprensión y el abordaje sanitario.