Abstract Concrete is a material susceptible to different degradation mechanisms that can lead to the formation of expansive products resulting from external sulfate attack (ESA). In this context, supplementary cementing materials (SCMs), like fly ash, metakaolin, silica fume, and rice husk ash, have effectively suppressed the effects caused by ESA. However, each SCM may present different behavior depending on the exposure conditions, sulfate type, SO 4 2- concentration, etc. Thus, this study presents a multicriteria decision-making analysis of fixed binder content for mortars (1: 3.2 a/agl=0.60) aiming to achieve the best performance against ESA (exposure to Na 2 SO 4 or MgSO 4 ). The criteria selected for the decision-making analysis are the sustainability impact of the mixture, economic performance, and the effect of ESA on the mechanical properties and durability of the mortars. The results indicate that the most suitable composition for aggressive environments containing Na 2 SO 4 was the mortar containing 10% rice husk ash and, for exposure to MgSO 4 , the use of fly ash in the same proportion. . (ESA) context SCMs, SCMs (SCMs) metakaolin fume However conditions type concentration etc Thus decisionmaking decision making 1 (1 32 3 3. a/agl=0.60 aagl060 aagl agl 0 60 ) mixture 10 proportion (ESA (SCMs ( a/agl=0.6 aagl06 6 a/agl=0. aagl0 a/agl=0 a/agl= a/agl

Resumo O concreto é um material suscetível a diferentes mecanismos de degradação que podem causar a formação de produtos expansivos, como o ataque externo por sulfatos. As adições minerais, como a cinza volante, o metacaulim, a sílica ativa e a sílica de casca de arroz são opções que possuem sua eficácia comprovada em argamassas e concretos expostos a ambientes com sulfatos. O presente estudo busca, por meio de um método de análise multicritérios de decisão, realizar a escolha do teor de aglomerante em argamassas (1: 3,2 a/agl=0,60) que apresentar melhor desempenho frente ao ataque externo por sulfato de sódio (Na2SO4) e magnésio (MgSO4). Tendo uma base de dados pré-definida, foram escolhidos critérios e subcritérios para composição da matriz hierárquica, levando em consideração a sustentabilidade, desempenho econômico das diferentes composições e o efeito do ataque químico nas propriedades mecânicas e na durabilidade das argamassas. Ao final da análise, a composição mais indicada para ambientes agressivos contendo Na2SO4 foi a argamassa contendo 10% de sílica da casca de arroz em substituição parcial ao cimento Portland e, para a exposição ao MgSO4, a utilização de cinza volante na mesma proporção. expansivos sulfatos minerais metacaulim busca decisão 1 (1 32 3 2 3, a/agl=0,60 aagl060 aagl agl 0 60 NaSO Na SO (Na2SO4 MgSO4. MgSO4 MgSO . (MgSO4) prédefinida, prédefinida pré definida, definida pré-definida hierárquica sustentabilidade Na2SO 10 proporção ( a/agl=0,6 aagl06 6 (Na2SO (MgSO4 a/agl=0, aagl0 (MgSO a/agl=0 a/agl= a/agl

Abstract While literature suggests more aggressive cigarette tax reforms to reduce its affordability as well as the tobacco epidemic the tobacco industry argues that these measures, would affect the economy. The goal of this study is to analyze the size of the tobacco sector in Mexico through specific relevant variables on prices and brands and simulate different tobacco excise reforms. An increase in tobacco taxes would indeed decrease consumption and would increase revenues as well, when considering different and recent tobacco price elasticities. Elasticity was estimated for the year 2020 and changes on prices were computed by considering the most recent tobacco tax reforms in 2021 which updated the price according to rise on inflation and two additional reforms by using distinct cigarette brands. The results indicate that a specific tax of an additional peso and $1.50 pesos per cigarette would reduce consumption in the range from 21.7% to 27.7% and increase revenues from 13.4% to 22.7%. The novelty of this work is that the greatest reduction in consumption would be observed in lower-priced brands.

Resumen Si bien la literatura sugiere establecer reformas impositivas al tabaco más agresivas con el fin de reducir su asequibilidad y combatir la epidemia del tabaquismo, la industria tabacalera argumenta que dichas medidas afectarían a la economía del país. El objetivo del estudio es analizar la dimensión del sector tabacalero en México a través de variables clave sobre precios y marcas, así como cantidades consumidas y simular reformas al impuesto especial del tabaco. Un incremento de los impuestos al tabaco permite disminuir el consumo y aumentar la recaudación considerando elasticidades-precio del tabaco recientes. Se calculó la elasticidad al 2020 y el cambio en los precios considerando la reforma reciente de 2021 que actualizó por inflación el IEPS asi como dos reformas impositivas adicionales a los cigarros y sus marcas. Los resultados indican que un impuesto específico de un peso adicional y $1.50 pesos por cigarrillo reduciría el consumo en el rango del 21.7% al 27.7% e incrementaría la recaudación del 13.4% al 22.7%. Lo novedoso de este trabajo es que la mayor reducción en consumo se observa en las marcas de menor precio.

Resumen Problema: tradicionalmente se ha excluido de la esfera de consideración moral tanto al ambiente como a otros animales, aun cuando una relación positiva con ellos reporta beneficios para la salud de unas y otras criaturas y promueve el desarrollo de empatía y la emisión de conductas prosociales (Ngai, Yu, Chau, Lee y Wong, 2021). De hecho, en las últimas décadas se han observado casos de zoonosis, uso inadecuado de recursos, deterioro del ambiente y un aumento de casos registrados de abuso animal. El abuso animal, fenómeno complejo y multideterminado, frecuentemente funciona como precursor o indicador de otras conductas calificadas como “antisociales”, violentas y no violentas. Respecto del rol que juega la empatía en la emisión o inhibición de conductas agresivas y de cuán generalizable es la empatía interespecie, existe evidencia contradictoria y se resaltan aquí tres fenómenos de interés: erosión empática, desensibilización progresiva a la violencia y fatiga por compasión. Objetivo: determinar si los niveles de empatía, la disposición a comportarse de manera abusiva contra otros animales y la conducta efectiva de abuso animal se relacionan con el contexto de formación preprofesional, el género autopercibido y la tenencia actual y/o previa de animales de compañía en estudiantes universitarios que cursan el tramo final de la Licenciatura en Psicología. Metodología: diseño ex post facto retrospectivo de grupo único (N = 241). Se aplicó un cuestionario autoadministrado que incluyó el Interpersonal Reactivity Index, la Animal Empathy Scale, la Animal Abuse Proclivity Scale y la cantidad y frecuencia de conductas efectivas de abuso animal. Contribución: se evidencia sobre el aporte del género autopercibido a la relación entre diversas medidas de empatía y el abuso hacia otros animales y se refuerza la tesis de la no generalizabilidad de la empatía interespecie.

Abstract Problem: Traditionally, both the environment and other animals have been excluded from the sphere of moral consideration, even though humans’ positive relationship with them brings benefits for the health of both creatures and promotes the development of empathy and the display of prosocial behaviors (Ngai, Yu, Chau, Lee & Wong, 2021). In fact, in recent decades there have been cases of zoonoses, inappropriate use of resources, deterioration of the environment and an increase in recorded cases of animal abuse. Animal abuse, a complex and multi-determined phenomenon, frequently works as a precursor or indicator of other behaviors classified as “antisocial”, violent and non-violent. There is conflicting evidence regarding the role that empathy plays in the emission or inhibition of aggressive behaviors and how generalizable interspecies empathy is. In this respect, three phenomena of interest stand out: empathic erosion, progressive desensitization to violence and compassion fatigue. Objective: To determine whether the levels of empathy, the willingness to behave abusively against other animals, and actual animal abuse behavior are related to the context of pre-professional training, self-perceived gender, and current and/or previous ownership of other companion animals in university students who are in the final stage of their training to obtain their university degree in Psychology. Methodology: Retrospective ex post facto single case design (N=241). A self-administered questionnaire was applied that included the Interpersonal Reactivity Index, the Animal Empathy Scale, the Animal Abuse Proclivity Scale and the quantity and frequency of effective animal abuse behaviors. Contribution: the contribution of self-perceived gender to the relationship between various measures of empathy and abuse towards other animals is evidenced, and the thesis of the non-generalizability of interspecies empathy is reinforced.

Thyroid cancer (TC) is the first malignant tumor in endocrine glands, and it is estimated that by 2030 it will be in the top five cancers worldwide. In Chile, TC was recently included as pathology No. 82 with Explicit Health Guarantees, which implies allocating significant public and private resources to the treatment of patients with a cancer that is on the rise. There are groups of young patients with small tumors that present a more aggressive clinical behavior, where decision-making could be advanced. Specifically, a group of patients under 55 years of age with tumors less than 2 cm in size but with regional metastases, that lack indication for radioiodine therapy and could require complementary treatment or present a worse evolution. Clinical and molecular tools to guide appropriate treatment in patients with lymph node metastases are limited and have not been updated. There are tumorigenicity and prognostic factors, such as EpithelialMesenchymal Transition (EMT) and Cancer Stem Cells (CSC) markers that have been incorporated into the study of other tumors and recently in thyroid cancer. Studies linking EMT and CSC with TC currently point to molecular and genetic description, with few reports clinically correlating these findings (particularly in subgroups with particular characteristics of aggressiveness) and proposing them as tumorigenicity and prognosis markers. The description of these biomarkers in the described population could facilitate decision-making regarding follow-up, surgical therapy, and radioiodine therapy.

Resumen El cáncer de tiroides (CT) es el primer tumor maligno en glándulas endocrinas, y se estima que al 2030 estará en el top cinco de cáncer a nivel mundial. En Chile, el CT fue incluido, recientemente, como la patología N° 82 con Garantías Explícitas de Salud, lo que implica destinar importantes recursos públicos y privados al tratamiento de pacientes con un cáncer que va en aumento en el mundo. Existen grupos de pacientes jóvenes con tumores pequeños que presentan un comportamiento clínico más agresivo desde el inicio, donde se podría adelantar la toma de decisiones. Específicamente, destaca un grupo de pacientes menores de 55 años con tumores pequeños menores de 2 cm, pero con metástasis regionales, que quedan fuera de la indicación de radioyodoterapia y podrían requerir tratamiento complementario o presentar peor evolución. Las herramientas clínicas y moleculares para guiar el tratamiento adecuado en pacientes con metástasis linfonodales son limitadas y no han sido actualizadas hasta el momento. Existen factores de tumorigenicidad y pronóstico, tales como los marcadores de Transición Epitelio-Mesenquimal (TEM) y Cáncer Stem Cells (CSC) que se han incorporado al estudio de otros tumores y recientemente en cáncer de tiroides. Actualmente estudios que relacionan TEM y CSC con CT apuntan a la descripción molecular y genética, con escasos reportes que correlacionen, clínicamente, estos hallazgos, (particularmente en subgrupos con características particulares de agresividad) y que los propongan como marcadores de tumorigenicidad y pronóstico. La descripción de estos biomarcadores en la población descrita podría facilitar la toma de decisiones en cuanto a seguimiento, terapia quirúrgica y radioyodoterapia.

Abstract Gestational trophoblastic disease (GTD) is a condition in which the trophoblast, a layer of cells surrounding the embryo, develops abnormally. GTD includes both pre-malignant and malignant pathologies, such as hydatidiform mole, choriocarcinoma, invasive mole, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Although GTD is rare, it affects about 1 to 3 out of every 1,000 pregnancies in North America and Europe. Choriocarcinoma is the most aggressive form of GTD, as it can quickly invade blood vessels and metastasize to other parts of the body. However, it is highly responsive to chemotherapy, with a cure rate of over 90%. In this case, a 40-year-old patient presented to the emergency department with sudden dyspnea due to pulmonary embolism. After starting anticoagulation therapy, she developed hemoperitoneum due to the spread of choriocarcinoma to her liver, as well as pulmonary metastases. This case is noteworthy because of its unusual presentation and aggressive nature, underscoring the importance of early diagnosis and treatment.

Resumen La enfermedad trofoblástica gestacional (ETG) es un trastorno proliferativo del trofoblasto. Incluye la mola hidatidiforme, el coriocarcinoma, la mola invasiva, el tumor trofoblástico del lecho placentario y el tumor trofoblástico epitelioide. Las últimas cuatro hacen parte de la neoplasia trofoblástica gestacional, que agrupa menos del 1% de todos los tumores ginecológicos. La incidencia de la ETG puede variar, siendo aproximadamente de 1 a 3 de cada 1.000 embarazos en América del Norte y Europa. El coriocarcinoma es la forma más agresiva por su rápida invasión vascular y compromiso metastásico. Sin embargo, es un tumor muy quimiosensible con una alta tasa de respuestas y posibilidad de curación superior al 90%. Se presenta el caso de una paciente de 40 años quien ingresó al servicio de urgencias por disnea súbita secundaria a tromboembolia pulmonar y posteriormente tras el inicio de anticoagulación presentó hemoperitoneo debido a lesiones hepáticas metastásicas de un coriocarcinoma, además de compromiso metastásico pulmonar. Se presenta este caso por ser una patología poco frecuente, agresiva y con presentaciones inusuales, con el fin de mostrar la importancia de un diagnóstico y tratamiento oportuno.

Abstract Frequently, aggressiveness and violence are used as synonymous. However, these are two complex and different phenomena that scientists and philosophers have studied. In this paper, we make a difference between aggressiveness and violence. Aggressiveness must be considered utilitarian behavior that harms or destroys objects or subjects. Aggressiveness is a primitive way to conduct, and here, we discuss anatomic and functional encephalic systems. This involuntary and instinctive behavior is triggered when the animal is required to hunt a press, defend its territory when young, or compete for a mate for reproductive purposes. The aggressiveness will be violence when it pursues a social, political, economic, or criminal goal. A violent or aggressive act is not distinguished by the outcome but by intentionality. Indeed, a violent action could have the same material consequences as an aggressive act with a different goal. Aggression-violence is a biological phenomenon and the result of culture, societal life, political relations, and current moral conditions. We often tend to simplify the phenomena, and we have discussed aggressiveness-violence, but there are also other phenomena, such as empathy and mirror behavior. Empathy, compassion, and affection should be studied alongside the aggressive-violent process.

Abstract The aim of this study was to analyze the conditions of both failing and non-failing students in relation to the disciplinary measures and sanctions implemented in secondary schools in the city of Chihuahua. Data from 479 students were examined, including 109 who currently had at least one failing subject. The instrument used was a Likert-scale survey focused on the perception of violence-related situations in the school environment. The survey was divided into three sections: Performance and school environment; Behavior and Bullying. The most notable results indicate that punishments and sanctions are more closely related to situations within the school environment that become monotonous, as well as the presence of aggressive behaviors from teachers and the application of various types of sanctions. These circumstances lead to learning difficulties for the students and, consequently, higher rates of school failure.

Resumo O objetivo deste estudo foi analisar as condições dos alunos reprovados e não reprovados em relação às medidas disciplinares e sanções implementadas nas escolas secundárias da cidade de Chihuahua. Para isso, foram examinados dados de 479 alunos, incluindo 109 que naquele momento tinham pelo menos uma disciplina reprovada. O instrumento utilizado foi uma pesquisa com escala tipo Likert focada na percepção de situações violentas no ambiente escolar. A pesquisa foi dividida em três seções: desempenho escolar e ambiente, comportamento e bullying. Os resultados mais notáveis indicam que as punições e sanções estão mais relacionadas com situações do ambiente escolar que se tornam monótonas, bem como com a presença de comportamentos agressivos por parte dos professores e a aplicação de diferentes tipos de sanções. Estas circunstâncias acarretam dificuldades no processo de aprendizagem dos alunos e, consequentemente, maiores índices de fracasso escolar.

Resumen El objetivo de este estudio fue analizar las condiciones de los estudiantes reprobados y no reprobados en relación con las medidas disciplinarias y sanciones implementadas en escuelas secundarias de la ciudad de Chihuahua. Para ello, se examinaron los datos de 479 estudiantes, incluyendo 109 que en ese momento tenían al menos una materia reprobada. El instrumento utilizado fue una encuesta con escala tipo Likert enfocada en la percepción de situaciones de violencia en el entorno escolar. La encuesta se dividió en tres secciones: desempeño y ambiente escolar, comportamiento y bullying. Los resultados más destacados señalan que los castigos y sanciones están más relacionadas con situaciones en el entorno escolar que se vuelven monótonas, así como con la presencia de comportamientos agresivos por parte de los docentes y la aplicación de distintos tipos de sanciones. Estas circunstancias conducen a dificultades en el proceso de aprendizaje por parte de los estudiantes y, como resultado, a tasas más altas de reprobación escolar.

BACKGROUND: Hereditary breast cancer is characterised by the presence of a pathogenic sequence variant passed from one generation to the next. These cancers are aggressive, develop early, and account for 5 - 10% of all breast cancer cases. In South Africa (SA), the common variants that predispose to hereditary breast cancer have been well documented among white patients and form part of screening panels during targeted testing. For non-white patients, common variants are not well understood, and as such, all populations are offered the same test optimised for white patients. This carries a risk of misdiagnosis, the consequences of which include recurrence and increased mortality OBJECTIVES: To retrospectively describe genetic trends in the black African and Indian breast cancer patients from KwaZulu-Natal Province, SA METHODS: We reviewed clinical and genetic data of breast cancer and high-risk patients who consulted at Inkosi Albert Luthuli Central Hospital between 2011 and 2021. Inclusion criteria were based on clinical and demographic characteristics as defined by SA clinical guidelines RESULTS: Black African patients were young (mean 37.6 years, standard deviation 11.16) and had the majority of triple-negative tumours (37.5%). Indians represented 50% of bilateral breast cancers and of high-risk individuals. We identified 30 pathogenic BRCA1/2 sequence variants, four large genomic rearrangements and 13 variants of unknown significance. Twenty black patients carried 12, 13 white patients carried 4, 25 Indian patients carried 16, and 3 coloured patients carried 3 pathogenic sequence variants. The most frequent variants were BRCA2 c.5771_5774del, p.Ile1924fs among black patients, BRCA2 c.7934del, p.Arg2645fs among white patients, and BRCA2 c.8754+1G>A among Indian patients. None of the founder mutations common in white patients was reported in either black, Indian or coloured patients, which explains why black, Coloured and Indian SA patients consistently test negative during targeted screening CONCLUSION: This study highlights unique genetic trends for SA populations and the need for more inclusive targeted tests that are optimal for these populations

Resumo: Introdução: Comportamentos agressivos, como bullying ou Bullying Escolar (BE) na população, não são eventos isolados e afetam seriamente a saúde socioemocional daqueles que o sofrem. Objetivo: O objetivo deste estudo foi realizar uma revisão sistemática das publicações existentes sobre Educação Física (EF) e Atividade Física (AF). Materiais e métodos: Foi desenhada uma pesquisa baseada na metodologia PRISMA. A busca por informações foi desenvolvida em quatro bases de dados: WOS, PUBMED, SCIELO e ELSEVIER, entre os anos de 2015 a 2020. Resultados: Um total de 53 artigos foram encontrados; após serem analisados pelos critérios de inclusão e exclusão, 18 estudos foram considerados para análise. Espanha, Brasil e Colômbia concentram um maior número de publicações com grande variabilidade de tamanho de amostra para ambos os sexos, principalmente durante a adolescência. Os conceitos mais utilizados foram Bullying; Vitimização, Violência Escolar, Cyberbullying, Autoestima dentro do contexto de EF e AF. Conclusão: Destaca-se a necessidade de tornar visível o problema na EF e AF, devido ao seu impacto na saúde física e emocional e na aprendizagem motora.

Abstract: Introduction: aggressive behaviors such as bullying or School Bullying (SB) in the population are not an isolated event and seriously affect the socio-emotional health of those who suffer it. Objective: the aim of this study was to carry out a systematic review of existing publications on Physical Education (PE) and Physical Activity (PA). Materials and methods: a research was designed based on PRISMA methodology. The search for information was developed in four databases WOS, PUBMED, SCIELO and ELSEIVER between the years 2015 to 2020. Results: A total of 53 articles were found, after being analyzed by inclusion and exclusion criteria, 18 studies were considered for analysis. Spain, Brazil and Colombia concentrate a greater number of publications with great variability of sample size for both females and males mainly during adolescence. The most used concepts were Bullying; Victimization, School Violence, Cyberbullying, Cyberbullying, Self-esteem within the context of PE and PA. Conclusion: the need to make the problem visible in PE and PA is highlighted, due to its impact on physical and emotional health and motor learning.

Resumen: Introducción: las conductas agresivas como el bullying o acoso escolar (AE) en la población no son un hecho aislado y afecta gravemente la salud socioemocional de quienes lo padecen. Objetivo: el presente estudio tuvo por objetivo realizar una revisión sistemática de las publicaciones existentes sobre educación física (EF) y actividad física (AF). Materiales y métodos: se diseñó una investigación orientada con base en metodología PRISMA. La búsqueda de la información se desarrolló en cuatro bases de datos WOS, PUBMED, SCIELO y ELSEIVER entre los años 2015 al 2020. Resultados: un total de 53 artículos fueron encontrados, luego de analizados por los criterios de inclusión y exclusión, 18 estudios fueron considerados para su análisis. España, Brasil y Colombia concentran una mayor cantidad de publicaciones con gran variabilidad del tamaño de la muestra tanto para damas como varones principalmente, durante la adolescencia. Los conceptos más utilizados fueron bullying, victimización, violencia escolar, ciberacoso, autoestima dentro del contexto de EF y AF. Conclusión: se destaca la necesidad de visibiliza el problema en la EF y AF, por su impacto en materia de salud física, emocional y aprendizaje motriz.

Resumen Antecedentes: El cáncer de mama (CM) representa un problema de salud pública entre las mujeres. A pesar de la incidencia y las disparidades en el estatus económico, el estado de Guerrero en México demuestra una tasa de mortalidad por cáncer de mama más baja. Objetivo: Este estudio investiga las características epidemiológicas, las modalidades de tratamiento y los resultados de supervivencia de los pacientes con CM en Guerrero y compara estos hallazgos con datos nacionales. Método: Se analizó una cohorte retrospectiva de 923 pacientes con CM atendidos en el Instituto Estatal de Cancerología Dr. Arturo Beltrán Ortega, del 2010 al 2018. Para determinar los factores pronósticos que afectan la supervivencia, empleamos el análisis de supervivencia general y el modelo de riesgos proporcionales de Cox. Resultados: La tasa de supervivencia a 5 años fue del 73% (IC 95%: 69-76). Los pacientes con BC ≤ 40 años mostraron tasas de supervivencia más bajas y un riesgo de mortalidad 1.5 veces mayor. Al comparar el subtipo triple negativo con los tumores HER2 positivos, no se observaron diferencias significativas en la reducción del riesgo de muerte. Conclusión: A pesar de una mayor prevalencia de subtipos moleculares agresivos en Guerrero, los pacientes comparten características clínicas y epidemiológicas con sus homólogos de otras regiones mexicanas.

Abstract Background: Breast cancer (BC) represents a public health concern among women. Despite the incidence and disparities in economic status, the state of Guerrero in Mexico demonstrates a lower BC mortality rate. Objective: This study investigates the epidemiological characteristics, treatment modalities, and survival outcomes of BC patients in Guerrero, and compares these findings with national data. Method: A retrospective cohort of 923 BC patients treated at the Instituto Estatal de Cancerología Dr. Arturo Beltrán Ortega, from 2010 to 2018 was analyzed. To determine the prognostic factors affecting survival, we employed overall survival analysis and the Cox proportional hazards model. Results: The 5-year survival rate was of 73% (CI 95%: 69-76). BC patients ≤ 40 years exhibited lower survival rates and a 1.5-fold higher risk of mortality. When comparing the triple-negative subtype to HER2-positive tumors, no significant differences in reducing the risk of death were observed. Conclusion: Despite a higher prevalence of aggressive molecular subtypes in Guerrero, patients share clinical and epidemiological features with their counterparts in other Mexican regions.

Abstract With the upsurge of community uptake in popula tion-based early screening for autism, the main obstacle to increasing access to early treatment and intervention services is the extremely limited access to high quality diagnosis, specifically the shortage of expert clinicians. Diagnostic evaluation models deployed by academic cen ters of excellence, which typically require the investment of 6-10 hours by specialized multidisciplinary teams, is not a viable solution to the vast needs of communities, resulting in parents’ “diagnostic odysseys” and delays, often of several years, for treatment, interventions and supports. Biomarker-based objective procedures for early diagnosis and assessment of autism are now available, clinically validated, and cleared for broad implementa tion by the US Food and Drug Administration (FDA). They are intended to increase access while maintaining high quality. Such solutions, however, will require change in entrenched models of diagnostic care, and aggressive prioritization of the needs of the community at large. If these innovations are successful, the number of children diagnosed in the first three years of life will double or triple. This will, in turn, require much greater inves tments in resources for treatment, including massive workforce training of providers capable of delivering community-viable caregiver-mediated interventions, and of early educators capable of serving autistic children in therapeutic inclusive preschool settings.

Resumen Con el aumento de la aceptación comunitaria de la detección temprana del autismo basada en la pobla ción, el principal obstáculo para aumentar el acceso al tratamiento temprano y a los servicios de intervención es el acceso extremadamente limitado a un diagnóstico de alta calidad, específicamente la escasez de médicos expertos. Los modelos de evaluación diagnóstica imple mentados por centros académicos de excelencia, que normalmente requieren la inversión de 6 a 10 horas por parte de equipos multidisciplinarios especializados, no son una solución viable para las vastas necesidades de las comunidades, lo que resulta en “odiseas diagnósti cas” y retrasos, a menudo de gran importancia, para los padres varios años, para tratamiento, intervenciones y apoyos. Los procedimientos objetivos basados en bio marcadores para el diagnóstico temprano y la evaluación del autismo ya están disponibles, clínicamente validados y aprobados para su amplia implementación por la Ad ministración de Alimentos y Medicamentos de EE. UU. (FDA). Su objetivo es aumentar el acceso manteniendo una alta calidad. Sin embargo, tales soluciones requeri rán cambios en los modelos arraigados de atención de diagnóstico y una priorización agresiva de las necesida des de la comunidad en general. Si estas innovaciones tienen éxito, el número de niños diagnosticados en los primeros tres años de vida se duplicará o triplicará. 51 Esto, a su vez, requerirá inversiones mucho mayores en recursos para el tratamiento, incluida la capacitación masiva de la fuerza laboral de proveedores capaces de brindar intervenciones comunitarias viables mediadas por cuidadores, y de educadores tempranos capaces de atender a niños autistas en entornos preescolares terapéuticos inclusivos.

Resumen Objetivo La enfermedad de Caffey o hiperostosis cortical infantil es una enfermedad rara que afecta uno o más huesos en los primeros meses de vida y debido a su baja incidencia está subdiagnosticada, y por tanto se aplican procedimientos invasivos innecesarios en su estudio y tratamiento. Se presenta un caso clínico atípico de enfermedad de Caffey en una paciente mayor de 1 año de edad y su resolución. Caso clínico El servicio de Cirugía Maxilofacial del Hospital Provincial Pediátrico Eduardo Agramonte Piña de Camagüey, Cuba, atiende a una niña de 1 año y 10 meses que se encontraba hospitalizada por presentar una inflamación alarmante en la región facial y cervical precedida de un cuadro febril y dificultad para alimentarse. Se indicaron los estudios apropiados, cuyos resultados, junto a las características clínicas, permitieron diagnosticar la enfermedad de Caffey. Aunque sea una enfermedad rara, es importante estudiarla para realizar un correcto análisis de cada caso y diferenciarla de otras enfermedades que requieren de conductas terapéuticas agresivas.

Abstract Aim Caffey’s disease or infantile cortical hyperostosis is a rare disease that affects one or more bones in the first months of life and due to its low incidence, it is underdiagnosed, and therefore unnecessary invasive procedures are applied in its study and treatment. An atypical clinical case of Caffey’s disease in a patient older than 1 year and its resolution is presented. Case report The Maxillofacial Surgery service of the Eduardo Agramonte Piña Provincial Pediatric Hospital in Camagüey, Cuba, takes the case of a 1 year and 10-month-old female patient who was hospitalized for an alarming inflammation in the facial and cervical region, preceded by a fever and difficulty to eat. The appropriate studies were indicated, which results, together with the clinical characteristics, allowed the diagnosis of Caffey’s disease. Although it is a rare entity, it is important to study it to carry out a correct analysis of each case and differentiate it from other diseases that require aggressive therapeutic behaviors.

Abstract The application of inhibitors against metals and alloys corrosion in various aggressive environments is an excellent solution. The present study explored Cu corrosion inhibition in a 0.5 M H2SO4 solution by MP EO, from Western Morocco, using EIS and PDP analyses. GC coupled with MS revealed that MP EO is mainly composed of pulegone (23.38%), isomenthone (20.54%) and l-menthone (9.56%). MP inhibitory behavior was of mixed type. MO EO prevented Cu corrosion in H2SO4, with an IE(%) that increased with its Ct, at a maximum of 91.0%, with 1 g/L. The Cu surface was studied by SEM coupled with EDS.

Abstract Necrotizing fasciitis (NF) is a potentially life-threatening surgical emergency. It is a rapidly progressive infection of soft tissues, and mortality is related to the degree of sepsis and the general condition of the patient. It is a rare condition that requires a rapid diagnosis and surgical treatment is aggressive debridement. There are a small number of reported cases of perforation of a rectal malignancy leading to NF of the thigh. We present a case with rectal cancer in which the sciatic foramen had provided a channel for the spread of pelvic infection into the thigh.

Resumen La fascitis necrotizante es una emergencia quirúrgica potencialmente mortal. Es una infección de tejidos blandos rápidamente progresiva y la mortalidad está relacionada con el grado de sepsis y el estado general del paciente. Es una condición poco común que requiere un diagnóstico rápido, y el tratamiento quirúrgico consiste en un desbridamiento agresivo. Existe un pequeño número de casos notificados de perforación de neoplasia maligna de recto que conduce a fascitis necrotizante del muslo. Presentamos un caso de cáncer de recto en el cual el foramen ciático fue el canal para la propagación de la infección pélvica al muslo.

Resumen La compasión es aquella conducta que permite a la persona ser capaz de reconocer y validar el sufrimiento de otro ser vivo, generando apoyo que permita evitar ese dolor. El presente estudio buscó determinar las propiedades psicométricas de la escala de compasión a los animales, elaborada por López y colaboradores en el 2021. En el presente estudio, participaron un total de 421 universitarios de ambos sexos, seleccionados mediante un muestreo no probabilístico. Según el Análisis Funcional de Conducta se reflejan índices de ajuste adecuados (X./gl=2,52 < 3, SRMR= 0,03 < 0.08, CFI=0,97 > 0,95), así altos niveles de confiabilidad (0,92). La validez convergente y divergente se realizó con la Escala de conductas prosociales y la escala de conductas agresivas. Estos resultados permiten concluir que la escala cuenta con confiabilidad y validez en población peruana.

Abstract Compassion is that behavior that allows a person to recognize and validate the suffering of another living being, generating support to avoid that pain. The present study aimed to determine the psychometric properties of the animal compassion scale developed by López et al. in 2021. Four hundred twenty-one university students of both sexes participated in the present study; they were selected by non-probabilistic sampling. According to the Functional Behavior Analysis, adequate adjustment indices are reflected (X./gl=2.52 < 3, SRMR=0.03 < 0.08, CFI=0.97 > 0.95), as well as high levels of reliability (0.92). Convergent and divergent validity was performed with the Prosocial Behavior Scale and the Aggressive Behavior Scale. These results allow us to conclude that the scale has reliability and validity in the Peruvian population.