Abstract: The objective of this article is to show that the troops of New Spain, as well as those of independent Mexico, included elderly, infirm and mutilated individuals who were known as invalids, and who formed part of the New Spanish and Mexican social mosaic. Countless pieces of contemporary journalism and the many files held by Mexico’s General Archive of the Nation, among other repositories, allow for an exploration of the operation of the units to which they belonged, as well as their ailments, needs, concerns and political and military actions. This article is a product of my Master’s thesis, Damaged Merits: The Invalids of the Mexico City Military Sector, 1765-1840. It uses the social history of war and the history of the human body to better understand the public and personal experiences of combatants who acquired the condition of being an invalid due to amputation, weapons impact and other causes.

Resumen: El objetivo de esta investigación es exponer que las tropas de Nueva España, como las del México independiente, tuvieron entre sus filas a individuos viejos, enfermos y mutilados llamados inválidos, quienes formaron parte del mosaico social novohispano y mexicano. Bastantes notas periodísticas de la época y ricos expedientes resguardados en el Archivo General de la Nación de México, entre otros repositorios, permiten abordar en las siguientes líneas el funcionamiento de las unidades a las que pertenecieron, sus dolencias, carencias, preocupaciones y su actuación política y militar. Este artículo, producto de mi tesis de maestría titulada Beneméritos estropeados. Los inválidos del sector militar en la ciudad de México, 1765-1840, se apoya en la historia social de la guerra y la historia del cuerpo humano para comprender mejor la experiencia pública y personal de los combatientes que adquirieron la condición de inválido por amputación, el impacto de las armas y otras causas.

Abstract The main objective of this article is to study the representations, ideas and visions generated by the governmental and judicial elite of the Federal District regarding problems such as crimes against property, as well as the treatment and punishment of thieves, between 1823 and 1840. Its hypothesis is twofold: on the one hand, these representations of property crimes and their actors revolved around the consolidation of an ideal of property, which, although it did not emerge with the advent of the republic, configured the category of citizenship. Secondly, although the enlightened rhetoric regarding the punishment of such offenders had legal and juridical continuity, the exceptionality of some criminal laws left open the space for the administration of punishments contrary to the proportionality between crimes and punishments. The present proposal, therefore, seeks to study the class prejudices surrounding property rights and their violation, explained through the need to configure a new, moderately stable social and political order, which had the periodical press as its main organ of expression.

Resumen El presente artículo tiene como objetivo principal el estudio de las representaciones, las ideas y las visiones generadas por la élite gubernativa y judicial del Distrito Federal en torno a problemas como los delitos contra la propiedad, así como también el tratamiento y la punición a los ladrones, entre 1823 y 1840. Su hipótesis es doble: por una parte, dichas representaciones de los delitos contra la propiedad y sus actores giraron en torno a la consolidación de un ideal de propiedad, que si bien no surgió con el advenimiento de la república, configuró de un modo prístino la categoría de ciudadanía. En segundo término, aunque la retórica ilustrada con respecto al castigo de tales delincuentes tuvo continuidad legal y jurídica, la excepcionalidad de algunas leyes penales dejó abierto el espacio para la administración de castigos contrarios a la proporcionalidad entre delitos y penas. La presente propuesta, en consecuencia, busca estudiar los prejuicios de clase en torno a los derechos de propiedad y su vulneración, explicados a través de la necesidad de configurar un nuevo orden social y político medianamente estable, y que tuvo como principal órgano de expresión a la prensa periódica.

Abstract: This article explores an ethical tension that was visible from the 1840s on and that was crystallized in the 1842 Constituent Assembly regarding a civil morality put forward by government authorities. Its objective is to explore one instant in the historical process of disconnection between civil morality and religious morality, more discursive than real, based on an analysis of public opinion and the minutes of the Constitutional Congress. In the context of the country’s political mutations, this article presents a horizon of socioethical mutations tending toward secular virtue yet without pretending to constitute a rupture. This moral adjustment was not an abstract question: it had repercussions on rights such as the freedom of the press and educational freedoms, as well as in procedural issues such as the powers of the courts.

Resumen: El artículo explora una tensión ética visible a partir de la década de 1840 y cristalizada en el Constituyente de 1842 en torno a la postulación de una moral civil por parte de la autoridad estatal. El objetivo es analizar un instante del proceso histórico de desvinculación, más discursiva que fáctica, entre una moral civil y una moral religiosa a partir del estudio de la opinión pública y las actas del Constituyente. Las fuentes son sobre todo de tres tipos: periódicos, folletos y actas legislativas. El texto presenta un horizonte de mutaciones socioéticas tendientes a una virtud secular, pero sin pretensiones de ruptura en el contexto de una reorganización política. El ajuste moral no es una cuestión abstracta: repercute en cuestiones muy significativas, como la definición de las libertades de prensa y enseñanza, y en elementos procedimentales como las atribuciones de los jurados.

Abstract Introduction : Although therapeutic advances have improved results of cutaneous melanoma (CM), senti nel node-positive patients still have substantial risk to develop recurrent disease. We aim to investigate prog nostic indicators associated with disease recurrence in positive-sentinel lymph node biopsy (SLNB) patients in a Latin-American population. Methods : Retrospective analysis of CM patients and positive-SLNB (2010-2020). Patients were divided into two groups: Group A (completion lymph node dissection, CLND), Group B (active surveillance, AS). Association of demographics, tumor data and SLN features with recurrence-free (RFS), distant metastases-free (DMFS) and melanoma specific (MSS) survival was analyzed. Results : Of 205 patients, 45 had a positive SLNB; 27(60%) belonged to Group A and 18(40%) to Group B. With a median follow-up of 36 months, 16 patients (12 in Group A and 4 in Group B) developed recurrent dis ease and estimated 5-yr RFS at any site was 60% (CI95%, 0.39 - 0.77) (44.5% in CLND group vs. 22% in AS group; P = 0.20). Estimated 5-yr DMFS and MSS: 65% (CI 95%, 0.44 - 0.81) and 73% (CI 95%, 0.59 - 0.89) with no differ ences between groups (p = 0.41 and 0.37, respectively). Independent predictors of poorer MSS were extranodal extension (ENE) and MaxSize > 2 mm of melanoma deposit in SLN. Factors independently associated with DMFS: Breslow depth > 2 mm, ENE, number (≥ 2) of posi tive SN and CLND status. Conclusion : Primary tumor and SN features in mela noma provide important prognostic information that help optimize prognosis and clinical management. AS is now the preferred approach for most positive-SLNB CM patients.

Resumen Introducción : Si bien los avances terapéuticos han permitido mejorar los resultados del melanoma cutáneo (MC), los pacientes con ganglio centinela positivo (BGCP) aún tienen riesgo elevado de desarrollar recurrencia de la enfermedad. Nuestro objetivo fue investigar in dicadores pronósticos asociados a dicho evento en una población latinoamericana. Métodos : Análisis retrospectivo de pacientes con MC y BGCP entre 2010-2020. Los pacientes se dividieron en 2 grupos: Grupo A (linfadenectomía terapéutica) y Grupo B (Vigilancia activa, VA). Se analizaron datos demográficos, tumorales y características del GC junto con sobrevida-libre de recurrencia (SLR), libre de metástasis a distancia (SLMD) y específica de melanoma (SEM). Resultados : De 205 pacientes, 45 presentaron BGCP; 27 (60%) perteneció al Grupo A y 18 (40%) al Grupo B. Con una mediana de seguimiento de 36 meses, 16 pa cientes (12 en Grupo A y 4 en Grupo B) desarrollaron enfermedad recurrente con una SLR a 5 años de 60% (IC95%: 0.39-0.77) (44.5% en Grupo B vs. 22% en Grupo A; P = 0.20). Las SLMD y SEM estimadas a 5 años fueron de 65% (CI 95%, 0.44 - 0.81) y 73% (CI 95%, 0.59 - 0.89) sin diferencias entre ambos grupos (p = 0.41 y 0.37, respec tivamente). Los predictores independientes de peor SEM fueron: extensión extranodal (ENE) y MaxSize > 2mm de depósito tumoral en GC. Los factores asociados de forma independiente con SLMD fueron Breslow >2mm, ENE, número (≥ 2) de GC positivos y el status (positividad) de la linfadenectomía. Conclusión : Características del tumor primario y del GC brindan información importante que ayuda a optimi zar el pronóstico y manejo clínico de los pacientes con MC. La VA es actualmente el abordaje de elección para la mayoría de los pacientes con BGCP.

RESUMEN El presente trabajo analiza el impacto que tuvo la aplicación de la normativa edilicia del periodo posindependentista en el proceso de desaparición de la arquitectura colonial de Buenos Aires durante la primera mitad del siglo XIX. La prohibición de salientes en la planta baja de las fachadas fue aplicada en forma excepcional en lo que respecta al derecho privado, ya que operó con retroactividad sobre la arquitectura preexistente: todas las construcciones de la ciudad -iglesias y edificios públicos incluidos- fueron transformados para adaptarse a la nueva normativa en un acotado lapso de tiempo. Se picaron las pilastras, se recolocaron las rejas al plano de fachada y para quienes no cumplieron con el plazo estipulado, las obras fueron realizadas por el cuerpo de policía, que convirtió las fachadas en ruinas. Se presenta un primer abordaje sobre el tema a partir del trabajo con fuentes documentales y de campo que analiza los casos existentes en la ciudad.

ABSTRACT This article analyzes the impact of the enforcement of building regulations during the post independence period, on the process of the disappearance of colonial architecture in Buenos Aires during the first half of the 19th century. The prohibition of projections on the ground floor of facades was implemented in an exceptional way in terms of private law, since it operated retroactively on pre-existing architecture: all the constructions in the city -churches and public buildings included- were transformed to adapt to the regulations in a limited period of time. Pilasters were cut up, window bars were repositioned on the facade plan, and for those who did not comply with the stipulated deadline, the works were carried out by the police force, turning the facades into ruins. Various documentary sources were researched and a field study was conducted to survey existing cases in the city.

ABSTRACT The elution by imidazole is used in the purification process of non-alpha IL-2 mutein, specifically in the immobilized metal chelates affinity chromatography step (IMAC). In order to demonstrate that a new elution process is possible using cheaper solutions, changes were made in the former capture step. These changes consist on separate the size exclusion chromatography and the controlled oxidation stage which are currently performed together, as well as changing the elution solution. To achieve this, a 22 factorial design of experiments was performed to evaluate the effect of pH and molar concentration on recovery, purity, and particle diameter. The best results were obtained with the solution of sodium acetate 20 mmol L-1 pH 4 being similar to those obtained in the industry nowadays: 29 % recovery, 90 % of purity, and particle diameter 18,40 nm. The first contribution of this paper is to demonstrate the feasibility of using the new elution methodology. Moreover, by using the academic software SuperPro Designer, the actual capture step of the purification process (elution by Imidazole) was simulated, validated, and verified. To demonstrate the relationship between costs and benefits, the CH SFF matrix gel volume was incremented. This change increased costs at this stage. However, the productivity obtained grew to 109 mg h-1, 2.78 times greater than the current productivity. Therefore, the gross net increased by 879 325,00 $. This result constitutes the second contribution of this paper.

RESUMEN La elución por Imidazol se utiliza en la etapa de captura del proceso de purificación de la muteína Interleukina-2 no alfa, específicamente en la cromatografía de afinidad de quelatos metálicos inmovilizados (IMAC). Para demostrar que es posible una nueva forma de elución en IMAC haciendo uso de soluciones menos costosas, se realizaron cambios en esta etapa: separar la cromatografía de exclusión molecular y la oxidación controlada (se realizan actualmente de forma conjunta), además de cambiar la solución de elución. Para lograr el objetivo, se realizó un diseño de experimentos factorial 22 evaluando el efecto del pH y la concentración molar en el recobrado, la pureza y el diámetro de partícula. Los mejores resultados se obtuvieron con la solución de acetato de sodio 20 mmol L-1 pH 4, siendo similares a los obtenidos hoy en la industria: 29 % de recobrado, 90 % de pureza y un diámetro de partícula de 18,40 nm. La primera contribución de este trabajo es demostrar la viabilidad de utilizar la nueva metodología de elución. Haciendo uso del software académico SuperPro Designer, se simuló, verificó y validó esta etapa. Con el propósito de demostrar la relación entre costos y beneficios, siendo la segunda contribución de este trabajo, se incrementó el volumen de gel de la matriz CH SFF. Este cambio resultó en un aumento de los costos en esta etapa. Sin embargo, la productividad obtenida creció en 109 mg h-1, siendo 2,78 veces mayor a la productividad actual, acrecentándose los ingresos en $ 879 325,00.

Resumen El método Zaba fue una variación de lo que se conoció en Occidente en el siglo XIX como el método mnemotécnico polaco para enseñar Historia Universal, creado por Antoni Jazwinski en la década de 1820 y modificado por Jozef Bem en la década de 1830. Desde la década de 1840 en adelante, otro polaco, Napoleón Félix Zaba, desarrolló su propia versión del método y, durante las siguientes cuatro décadas, dictó conferencias sobre el mismo en países como Estados Unidos, Argentina, Australia, Nueva Zelanda y Brasil. El objetivo de este trabajo es analizar la recepción del método Zaba durante el paso de su promotor por Bahia, en junio y julio de 1871, cuando a sus conferencias asistía la alta esfera de la educación pública de la provincia, normalistas y maestros primarios, dando lugar a intentos de adaptación e implementación del método a la Historia de Brasil. Buscaremos comprender cómo los líderes percibieron la eficacia del método para la enseñanza de la Historia en Bahia y cómo profesores y normalistas movilizaron sus conocimientos y esfuerzos para adaptarse al contenido de las clases primarias. Universal 182 1830 184 adelante décadas Unidos Argentina Australia Brasil 1871 provincia primarios primarias 18 183 187 1

Abstract The Zaba method was a variation of what became known in the 19th century West as the Polish mnemonic method for teaching Universal History, created by Antoni Jazwinski in the 1820s and modified by Jozef Bem in the 1830s. At 1840 another pole, Napoleon Felix Zaba, developed his own version of the method and, over the next four decades, lectured on it in several, including Brazil. This work aims to analyze the reception of the Zaba method at his passage through Bahia, in 1871 june and july, when his lectures were attended by the high echelon of public education of that province, by normalists and primary teachers, giving rise to attempts to adapt the method to Brazil history. We aim to understand how the leaders perceived the effectiveness of the method for History Teaching in Bahia, and how the teachers and normalists mobilized their knowledge and efforts to adapt the issues to primary classes. th s 1830s 184 pole decades several Bahia 187 july province history classes 18 1

Resumo O método Zaba era uma variação do que ficou conhecido, no Ocidente do século XIX, como método mnemônico polonês para o ensino de História Universal, desenvolvido por Antoni Jazwinski nos anos 1820 e modificado por Jozef Bem nos anos 1830. A partir dos anos 1840, outro polonês, Napoleão Félix Zaba, desenvolveu uma versão própria do método e, nas quatro décadas seguintes, deu conferências sobre ele em vários países, inclusive o Brasil. O objetivo deste trabalho é analisar a recepção do método Zaba durante a passagem do seu divulgador pela Bahia, em meados de 1871, quando suas palestras foram assistidas pelo alto escalão da instrução pública da província, por normalistas e professores primários, ensejando tentativas de adaptação e implementação do método à História do Brasil. Buscaremos entender como os dirigentes perceberam a eficácia do método para o ensino de História na Bahia e como professores e normalistas mobilizaram seus conhecimentos e esforços para adaptá-lo ao conteúdo das classes primárias. conhecido XIX Universal 182 1830 1840 seguintes países Brasil 1871 província primários adaptálo adaptá lo primárias 18 183 184 187 1

ABSTRACT Body weight and vertical stratum utilization are important functional characteristics of species. Several studies have explored the capture success of different traps. These studies, however, did not explore how trappability is influenced by body weight. Here, we investigated the relationship between the weight of marsupial species caught in traps with trap type (wire cage and Sherman) and trap placement (ground and understory). For this we used data from Didelphis albiventris Lund, 1840 (n = 127; 75-958 g) and Gracilinanus agilis (Burmeister, 1854) (n = 327; 8.5-46 g) captured in semideciduous forest fragments in central Brazil. The results show that heaviest individuals of D. albiventris (391.01 ± 197.57 g) were captured more often by wire cage traps, regardless of trap placement. In contrast, G. agilis was trapped at similar rates regardless of weight, trap type or trap placement. We conclude that wire cage traps are more efficient at catching large marsupials weighing more than 300 g on average. Furthermore, the size of the individuals captured is not influenced by where the trap is placed (ground or understory). These findings contribute to a better understanding of the natural history and trappability of Neotropical marsupials. however Here Sherman ground understory. understory . understory) Lund 184 n 127 75958 75 958 75-95 Burmeister, Burmeister (Burmeister 1854 327 8.546 8546 8.5 46 8 5 8.5-4 Brazil D 391.01 39101 391 01 (391.0 19757 197 57 197.5 contrast G 30 average Furthermore 18 12 7595 7 95 75-9 185 32 546 8.54 854 85 8. 4 8.5- 391.0 3910 39 0 (391. 1975 19 197. 3 1 759 9 75- 54 391. (391 (39 (3 (

Abstract Until the second decade of the 19th century, the space south of the Salado River was indigenous territory. Twenty-five years later, immigrants began to arrive in villages like Tandil, forming what would later become the province of Buenos Aires. Specialists on indigenous people and immigrants have advanced in the understanding of these fields since the early 1980s. However, while some needed to atomize the object of study by nationality and even regionalisms, the others placed a largely anthropological emphasis on studying important chiefdoms while They advanced in categories that allowed us to unravel an indigenous world that was believed to be heterogeneous. A third group analyzed and discussed ideas about the Creoles, discovering that the gaucho was an almost exotic character and that they talked about him without delving into his abysmal distance between the local elite and the poor, deprived of all possibilities until 1880. The look was binary: indigenous and Creole, while the foreigners moved on stage like leading actors accompanied by the light of a spotlight. We propose to advance a holistic view, taking the Basque case as a witness, taking into account historicity and reviewing the documentation in search of energizing the whole. Also, recover the substantial relationship with an environment that was presented until some time ago as a suggestive scenography, with exceptions regarding the indigenous world. th century territory Twentyfive Twenty five Tandil Aires 1980s s However regionalisms heterogeneous Creoles poor 1880 binary Creole spotlight view witness whole Also scenography 188 18 1

Resumen Hasta la segunda década del siglo XIX el espacio al sur del río Salado (Argentina) era territorio indígena. Veinticinco años más tarde comenzaron a llegar inmigrantes a aldeas como Tandil, conformando lo que luego sería la provincia de Buenos Aires. Los especialistas en indígenas e inmigrantes han avanzado en la comprensión de estos campos desde el comienzo de los años 1980. Sin embargo, mientras unos necesitaron atomizar el objeto de estudio por nacionalidad e incluso regionalismos, otros pusieron un énfasis mayormente antropológico en estudiar cacicatos importantes mientras avanzaban en categorías que permitieron desenmarañar un mundo indígena que se creía heterogéneo. Un tercer grupo analizó y discutió ideas sobre los criollos, descubriendo que el gaucho fue un personaje casi exótico y que se hablaba del mismo sin adentrarse en su distancia abismal entre la élite local y los pobres, privados de toda posibilidad hasta 1880. La mirada era binaria: indígenas y criollos, mientras los extranjeros se movían en el escenario cual actores protagónicos a los que acompañaba la luz de un reflector. Nos proponemos avanzar en una mirada holística, tomando el caso vasco como testigo, que tenga en cuenta la historicidad y que revise la documentación en busca de dinamizar el conjunto. También buscamos recuperar la relación sustancial con un medio ambiente que se presentó hasta hace tiempo como una escenografía sugerente, salvo excepciones sobre el mundo indígena. Argentina (Argentina Tandil Aires 1980 embargo regionalismos heterogéneo criollos pobres 1880 binaria reflector holística testigo conjunto sugerente 198 188 19 18 1

RESUMO Tem se intensificado a busca por alternativas sustentáveis e menos poluentes, como o aproveitamento de resíduos de biomassa para fins energéticos, substituindo os combustíveis fósseis e derivados. O objetivo deste estudo foi avaliar o potencial energético de biomassas agrícolas e florestais para geração de energia. Além disso, determinar suas propriedades físicas, químicas e energéticas. Para realizar esta análise, utilizou-se cinco biomassas agrícolas e florestais de processos produtivos no estado de Pernambuco, são elas: bagaço de cana-de-açúcar, casca de eucalipto, cavaco de eucalipto, serragem de madeira e poda da arborização urbana do município de Recife. O bagaço de cana-de-açúcar (18.405 KJ/Kg), seguido pela serragem (18.115 KJ/Kg) e cavaco de eucalipto (18.024 KJ/Kg), obtiveram maior poder calorífico. Quanto à química elementar, o teor de hidrogênio foi o único que não apresentou diferença significativa entre as biomassas e o bagaço de cana apresentou os melhores valores de oxigênio e enxofre, além de alto teor de carbono. Em relação à densidade energética e ao IVC, o cavaco de eucalipto (6,16 GJ/m³ e 307, respectivamente) e a serragem (5,91 GJ/m³ e 32,86, respectivamente), apresentaram os maiores valores. Todas as biomassas avaliadas possuem potencial energético, porém, com base nas variáveis, o bagaço de cana-de-açúcar, a serragem e o cavaco de eucalipto tendem a apresentar maior combustibilidade. poluentes energéticos derivados energia disso físicas energéticas análise utilizouse utilizou Pernambuco elas canadeaçúcar, canadeaçúcar açúcar, açúcar Recife 18.405 18405 18 405 (18.40 KJ/Kg, KJKg KJ/Kg , KJ Kg 18.115 18115 115 (18.11 18.024 18024 024 (18.02 calorífico elementar enxofre carbono IVC 6,16 616 6 16 (6,1 GJm³ GJm GJ m³ m GJ/m 307 respectivamente 5,91 591 5 91 (5,9 3286 32 86 32,86 respectivamente, porém variáveis combustibilidade 18.40 1840 1 40 (18.4 18.11 1811 11 (18.1 18.02 1802 02 (18.0 6,1 61 (6, 30 5,9 59 9 (5, 328 3 8 32,8 18.4 184 4 (18. 18.1 181 18.0 180 0 6, (6 5, (5 32, 18. (18 ( (1

ABSTRACT The search for sustainable and less polluting alternatives has intensified, such as the use of biomass residues for energy purposes, replacing fossil fuels and derivatives. The objective of this study was to evaluate the energy potential of agricultural and forestry biomasses for energy generation, as well as to, determine their physical, chemical and energetic properties. To carry out this analysis five agricultural and forestry biomasses from productive processes in the state of Pernambuco were used, namely: sugarcane bagasse, eucalyptus bark, eucalyptus chips, wood sawdust and pruning of urban trees in the municipality of Recife. Sugarcane bagasse (18,405 KJ/Kg), followed by sawdust (18,115 KJ/Kg), and eucalyptus chips (18,024 KJ/Kg), had the highest calorific value. As for elemental chemistry, the hydrogen content was the only one that did not show a significant difference between the biomasses, and the sugarcane bagasse presented the best values of oxygen and sulfur, in addition to high carbon content. Regarding energy density and IVC, eucalyptus chips (6.16 GJ/m³ and 307, respectively), and sawdust (5.91 GJ/m³ and 32, 86, respectively), presented the highest values. All evaluated biomasses have energy potential, however, based on the variables, sugarcane bagasse, sawdust and eucalyptus chips, tend to have greater combustibility. intensified purposes derivatives generation physical properties used namely bark Recife 18,405 18405 18 405 (18,40 KJ/Kg, KJKg KJ/Kg , KJ Kg KJ/Kg) 18,115 18115 115 (18,11 18,024 18024 024 (18,02 value chemistry sulfur IVC 6.16 616 6 16 (6.1 GJm³ GJm GJ m³ m GJ/m 307 respectively, respectively respectively) 5.91 591 5 91 (5.9 32 86 however variables combustibility 18,40 1840 1 40 (18,4 18,11 1811 11 (18,1 18,02 1802 02 (18,0 6.1 61 (6. 30 5.9 59 9 (5. 3 8 18,4 184 4 (18, 18,1 181 18,0 180 0 6. (6 5. (5 18, (18 ( (1

Abstract This article analyzes the records of schoolbooks in the newspapers Publicador Maranhense (1842-1885), O Paiz (1863-1889), and Pacotilha (1880-1939), aiming to understand their influence in Maranhão education through the press. Cultural History theoretical- methodological assumptions are used to identify the school works and their materiality, the subjects involved in production control, the camouflages used as appropriation tactics, and the different conceptions, contents, and variations according to the contextual conditions. We conclude that schoolbooks had a prominent place in the press at the time, publicizing the local productions adopted nationally due to their quality or the authors' influence in the province. 18421885, 18421885 1842 1885 , (1842-1885) 18631889, 18631889 1863 1889 (1863-1889) 18801939, 18801939 1880 1939 (1880-1939) theoretical materiality control tactics conceptions contents conditions time authors province 1842188 184 188 (1842-1885 1863188 186 (1863-1889 1880193 193 (1880-1939 184218 18 (1842-188 186318 (1863-188 188019 19 (1880-193 18421 1 (1842-18 18631 (1863-18 18801 (1880-19 (1842-1 (1863-1 (1880-1 (1842- (1863- (1880- (1842 (1863 (1880 (184 (186 (188 (18 (1 (

Resumo Neste artigo, analisam-se os registros sobre livros escolares nos jornais Publicador Maranhense (1842-1885), O Paiz (1863-1889) e Pacotilha (1880-1939), objetivando-se compreender a influência que tiveram na instrução maranhense via imprensa. Identificam-se as obras escolares e sua materialidade, os sujeitos envolvidos no controle da produção e as camuflagens em uso como táticas de apropriação, para além das diferentes concepções, conteúdos e variações, conforme as condições contextuais à luz dos pressupostos teórico-metodológicos da história cultural. Conclui-se que os livros escolares no período ocuparam lugar de destaque na imprensa, divulgando-se a produção local que foi adotada em nível nacional, seja pela qualidade exigida, seja pela influência de seus autores na província. artigo analisamse analisam se 18421885, 18421885 1842 1885 , (1842-1885) 18631889 1863 1889 (1863-1889 18801939, 18801939 1880 1939 (1880-1939) objetivandose objetivando imprensa Identificamse Identificam materialidade apropriação concepções variações teóricometodológicos teórico metodológicos cultural Concluise Conclui divulgandose divulgando nacional exigida província 1842188 184 188 (1842-1885 1863188 186 (1863-188 1880193 193 (1880-1939 184218 18 (1842-188 186318 (1863-18 188019 19 (1880-193 18421 1 (1842-18 18631 (1863-1 18801 (1880-19 (1842-1 (1863- (1880-1 (1842- (1863 (1880- (1842 (186 (1880 (184 (18 (188 (1 (

Abstract The Brazilian tick fauna currently comprises 77 valid species categorized into two families: Ixodidae (53 species) and Argasidae (24 species). In the state of Alagoas, only six Ixodid ticks have been reported to date, with no previous reports of ticks in the Argasidae family. Here, we assessed 33 White-eared Opossum (Didelphis albiventris Lund, 1840) rescued in the metropolitan region of Maceió and referred to the Wild Animal Screening Center (Cetas) in the city. Upon arrival, the animals were examined for ectoparasites within 24 hours. In total, 10/33 (30%) opossums were found to be infested by 26 larvae of the argasid tick Ornithodoros mimon Kohls, Clifford & Jones, 1969. Morphological identification of ticks was corroborated by generating partial sequences of the mitochondrial 16S rRNA gene from three tick specimens. This study marks the first report of an argasid tick in the state of Alagoas. Future studies should investigate whether populations of both O. mimon ticks and their host, D. albiventris, in the state of Alagoas carry potential zoonotic agents capable of causing tick-borne diseases. 7 families 53 (5 (2 species. . date family Here 3 Whiteeared White eared Didelphis Lund 1840 Cetas (Cetas city arrival 2 hours total 1033 10 10/3 30% 30 (30% Kohls Jones 1969 S specimens O host D tickborne borne diseases 5 ( 184 103 1 10/ (30 196 18 (3 19

Resumo A fauna de carrapatos do Brasil compreende, atualmente, 77 espécies válidas, categorizadas em duas famílias: Ixodidae (53 espécies) e Argasidae (24 espécies). No estado de Alagoas, apenas seis carrapatos ixodídeos foram registrados até o momento, sem nenhum relato anterior de argasídeos. Neste estudo, 33 gambás-de-orelha-branca (Didelphis albiventris Lund, 1840), resgatados na região metropolitana de Maceió, foram encaminhados ao Centro de Triagem de Animais Silvestres (Cetas) da cidade. Ao chegarem, os animais foram submetidos a exames de ectoparasitas em um prazo de 24 horas. Do total, 10/33 (30%) deles foram encontrados infestados por 26 larvas do carrapato argasídeo Ornithodoros mimon Kohls, Clifford & Jones, 1969. A identificação morfológica dos carrapatos foi corroborada pela obtenção de sequências parciais do gene mitocondrial 16S rRNA de três espécimes deles. Este estudo marca o primeiro relato de um carrapato argasídeo no estado de Alagoas. Estudos futuros devem investigar se as populações de ambos os carrapatos, O. mimon e seu hospedeiro, D. albiventris, no estado de Alagoas, carregam potenciais agentes zoonóticos capazes de causar doenças transmitidas por carrapatos. compreende atualmente 7 válidas famílias 53 (5 (2 espécies. . Alagoas momento argasídeos 3 gambásdeorelhabranca gambás orelha branca Didelphis Lund 1840, 1840 , 1840) Maceió Cetas (Cetas cidade chegarem 2 horas total 1033 10 10/3 30% 30 (30% Kohls Jones 1969 S O hospedeiro D 5 ( 184 103 1 10/ (30 196 18 (3 19

SUMMARY OBJECTIVE: The aim of this study was to evaluate mitofusin-2 levels and fetal Doppler ultrasonography effects in patients with severe preeclampsia. METHODS: This single-center case-control study was conducted in the gynecology service of the university hospital in Van. A total of 90 pregnant women aged 18-40 years were included in the study. Of these, 30 are normal, 30 have mild preeclampsia, and 30 are pregnant with severe preeclampsia. In this study, especially in severe preeclampsia patients, serum mitofusin-2 levels and important fetal Doppler flows such as uterine arterial pressure, umbilical arterial pressure, and 1st and 5th minute Apgar scores, birth weight, and the relationship between postnatal outcomes such as week of birth and the number of patients in the neonatal intensive care unit were investigated. RESULTS: There was a significant difference between the three groups in terms of mitofusin-2 levels, which was the highest in the group (p<0.05). Maternal serum mitofusin-2 levels were positively correlated with uterine arterial pressure (r=0.543, p=0.007), umbilical arterial pressure (r=0.238, p=0.008), diastolic blood pressure, and systolic blood pressure (p<0.001). Receiver operating characteristic curve of mitofusin-2 in predicting preeclampsia is as follows: optimal cutoff 1.6 ng/mL; area under the curve: 0.861; 95%CI: 0.786-0.917; sensitivity: 83.9%; and specificity: 70.0%, (p≤0.001). A one-unit increase in mitofusin-2 resulted in a statistically significant 4.21-fold increase in preeclampsia risk. CONCLUSION: This study recommends the use of mitofusin-2 together with fetal Doppler ultrasound findings as a reliable indicator of preeclampsia severity. OBJECTIVE mitofusin2 mitofusin 2 mitofusin- METHODS singlecenter single center casecontrol case control Van 9 1840 18 40 18-4 these 3 normal st th scores weight investigated RESULTS p<0.05. p005 p p<0.05 . 0 05 (p<0.05) r=0.543, r0543 r 543 (r=0.543 p=0.007, p0007 p=0.007 , 007 p=0.007) r=0.238, r0238 238 (r=0.238 p=0.008, p0008 p=0.008 008 p=0.008) p<0.001. p0001 p<0.001 001 (p<0.001) follows 16 1 6 1. ng/mL ngmL ng mL 0.861 0861 861 95%CI 95CI CI 95 0.7860.917 07860917 0.786 0.917 786 917 0.786-0.917 sensitivity 83.9% 839 83 specificity 700 70 70.0% p≤0.001. p≤0.001 (p≤0.001) oneunit one 4.21fold 421fold fold 4.21 4 21 risk CONCLUSION severity 184 18- p00 p<0.0 (p<0.05 r=0.543 r054 54 (r=0.54 p000 p=0.00 00 r=0.238 r023 23 (r=0.23 p<0.00 (p<0.001 0.86 086 86 7860 0.7860.91 0786091 0786 0.78 0917 0.91 78 91 0.786-0.91 83.9 8 7 70.0 p≤0.00 (p≤0.001 21fold 421 4.2 p0 p<0. (p<0.0 r=0.54 r05 5 (r=0.5 p=0.0 r=0.23 r02 (r=0.2 (p<0.00 0.8 08 0.7860.9 078609 078 0.7 091 0.9 0.786-0.9 83. 70. p≤0.0 (p≤0.00 42 4. p<0 (p<0. r=0.5 r0 (r=0. p=0. r=0.2 0. 0.7860. 07860 07 09 0.786-0. p≤0. (p≤0.0 p< (p<0 r=0. (r=0 p=0 0.7860 0.786-0 p≤0 (p≤0. (p< r=0 (r= p= 0.786- p≤ (p≤0 (p r= (r (p≤

SUMMARY OBJECTIVE: The objective of this study was to investigate the allele frequencies of polymorphisms in genes CYP11A1 rs4886595 and CYP11A1 rs4887139 that are responsible for the steroidogenesis mechanism in polycystic ovary syndrome patients and control females. METHODS: Samples were obtained from the Department of Obstetrics and Gynecology in the Near East University Hospital from September 2019 to December 2019. Only the nonobese patients between the ages of 18–40 years were included in this study following informed consent. Obese patients and patients more than 40 years of age were excluded from the study. Nonobese women and normal ovulation were included in the control group. DNA was isolated from blood samples. Real-time polymerase chain reaction (PCR) was used to analyze single nucleotide polymorphisms (SNPs) in various genes linked to polycystic ovary syndrome. The studies were carried out using the samples obtained from 120 women, of whom 55 were nonobese and had normal ovulation, and 65 were polycystic ovary syndrome patients. The allelic frequencies of SNPs in genes linked to polycystic ovary syndrome were calculated using real-time PCR outcomes. RESULTS: The variation of the CYP11A1 rs4887139 G>A did not show any significance, while the variation of CYP11A1 rs4886595 C>A showed significant differences between the patient and the control groups (p=0.01), respectively. CONCLUSION: Future research ought to focus on elucidating the susceptible causes of polycystic ovary syndrome with a wide range of SNPs and more sample size. The genome-wide association studies in polycystic ovary syndrome patients of different origin will be important to identify candidate genes as well as proteins that are implied in polycystic ovary syndrome risk. OBJECTIVE CYPA CYP A CYP11A rs rs488659 rs488713 females METHODS 201 1840 18 18–4 consent 4 group Realtime Real time (PCR (SNPs 12 5 6 realtime real outcomes RESULTS GA G significance CA C p=0.01, p001 p p=0.01 , 0 01 (p=0.01) respectively CONCLUSION size genomewide genome risk rs48865 rs48871 20 184 1 18– p00 p=0.0 (p=0.01 rs4886 rs4887 2 p0 p=0. (p=0.0 rs488 p=0 (p=0. rs48 p= (p=0 rs4 (p= (p