Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.

Trata-se de uma revisão sobre os aspectos epidemiológicos da síndrome de imunodeficiência adquirida em crianças e sobre a transmissão vertical do vírus da imunodeficiência humana (HIV). Discutem-se as diversas vias pelas quais o HIV pode transmitir-se de mãe para filho, abordando questões inerentes à fisiopatologia da infecção intra-útero, periparto e/ou pós-parto.

This paper seeks to review the epidemiological aspects of the acquired immunodeficiency syndrome (AIDS) in children and the vertical transmission of the human immunodeficiency virus (HIV). The modes of mother-to-infant transmission are discussed, including physiopathological aspects of HIV infection in utero, during, and/or after delivery.

Trata-se de uma revisão sobre os aspectos epidemiológicos da síndrome de imunodeficiência adquirida em crianças e sobre a transmissão vertical do vírus da imunodeficiência humana (HIV). Discutem-se as diversas vias pelas quais o HIV pode transmitir-se de mãe para filho, abordando questões inerentes à fisiopatologia da infecção intra-útero, periparto e/ou pós-parto.

This paper seeks to review the epidemiological aspects of the acquired immunodeficiency syndrome (AIDS) in children and the vertical transmission of the human immunodeficiency virus (HIV). The modes of mother-to-infant transmission are discussed, including physiopathological aspects of HIV infection in utero, during, and/or after delivery.