Pesquisa | SciELO

ABSTRACT Background: Chronic myelogenous leukemia is a neoplastic proliferation of the granulocytic series. In Mexico, chronic myelogenous leukemia accounts for approximately 10% of all leukemias. Tyrosine-kinase inhibitors are considered front-line therapy in high-income countries, whereas allogeneic hematopoietic stem cell transplantation is a recognized therapeutic approach, mainly in low- and middle-income countries. Objective: To analyze the overall survival of persons with chronic myelogenous leukemia who have received tyrosine-kinase inhibitors or allogeneic hematopoietic stem cell transplantation in a medical center, since 1994, and briefly discuss the current indications of these treatments in the tyrosine-kinase inhibitors era. Methods: We retrospectively analyzed all patients with a diagnosis of chronic myelogenous leukemia treated in a medical center between 1994 and 2023; subsets of individuals who received an allogeneic hematopoietic stem cell transplantation or tyrosine-kinase inhibitors therapy as first-line treatment were analyzed. Results: 60 persons with chronic myelogenous leukemia were treated with allogeneic hematopoietic stem cell transplantation or tyrosine-kinase inhibitors: 35 received an allogeneic hematopoietic stem cell transplantation, whereas 25 were given tyrosine-kinase inhibitors. All patients who underwent an allogeneic hematopoietic stem cell transplantation engrafted successfully, and the procedure was completed on an outpatient basis in most cases (29/35). The median survival in allogeneic hematopoietic stem cell transplantation was 78.3 months (CI 95%: 0-205.6) and in persons given tyrosine-kinase inhibitors the median was not reached. Conclusion: Tyrosine-kinase inhibitors were significantly superior to allogeneic hematopoietic stem cell transplantation in prolonging the overall survival of persons with chronic myelogenous leukemia in our single institution experience. (Rev Invest Clin. 2024;76(2):91-6)

https://doi.org/10.24875/ric.23000274

Programa de telerrehabilitación en pacientes con fractura de radio distal: ensayo clínico controlado
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Pech-Argüelles, Roberto C.

; Miranda-Ortiz, Yetlanezi J.

; Velázquez-Hernández, Hector E.

; Domínguez-Cordero, Rafael

; Ruiz-Pacheco, Cecilia

; Figueroa-García, Juan

; Rojano-Mejía, David

Cirugía y cirujanos

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Fev 2024, Volume 92 Nº 1 Páginas 112 - 119

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: To determine the effectiveness of tele rehabilitation versus supervised treatment in the functional recovery of patients with distal radius fracture. Method: A randomized clinical trial was conducted that included 91 patients with distal radius fractures grades AO23 A and AO23B, which were randomly assigned to a treatment group, the supervised rehabilitation group received for two weeks a program of 10 treatment sessions and the tele rehabilitation group received through the Moodle platform instructions to carry out the rehabilitation program. Outcome measures (functionality, active range of motion, hand grip strength, quality of life and pain) were measured at the time of admission to rehabilitation and at 1, 3 and 6 months. Results: In both treatment groups at 6 months, statistically significant intragroup differences in functionality were demonstrated, with no intergroup differences. Conclusions: At 6 months, both rehabilitation programs increase functionality, range of motion, quality of life and decrease pain, without statistically significant differences intergroup.

Resumen Objetivo: Determinar la efectividad de la telerrehabilitación en comparación con el tratamiento supervisado en la recuperación funcional de los pacientes con fractura de radio distal. Método: Se realizó un ensayo clínico aleatorizado que incluyó 91 pacientes con fracturas de radio distal de grados AO23A y AO23B, los cuales se asignaron aleatoriamente a un grupo de rehabilitación supervisado que recibió durante 2 semanas un programa de 10 sesiones de tratamiento o un grupo de telerrehabilitación que mediante la plataforma de Moodle recibió instrucciones para realizar el programa de rehabilitación. Las medidas de resultado (funcionalidad, rango de movimiento activo, fuerza de prensión de la mano, calidad de vida y dolor) se midieron en el momento del ingreso a rehabilitación y a los 1, 3 y 6 meses. Resultados: A los 6 meses, ambos grupos de tratamiento demostraron diferencias estadísticamente significativas intragrupo en la funcionalidad, sin diferencias intergrupo. Conclusiones: A los 6 meses, ambos programas de rehabilitación aumentan la funcionalidad, el rango de movimiento y la calidad de vida, y disminuyen el dolor, sin diferencias estadísticamente significativas intergrupo.

https://doi.org/10.24875/ciru.22000328

Survival at 3, 6 and 12 months in patients diagnosed with community-acquired pneumonia in Colombia: a retrospective cohort study 3 1 communityacquired community acquired Colombia
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Tuta-Quintero, Eduardo

; Torres-Arevalo, Daniela

; Bastidas-Goyes, Alirio Rodrigo

; Aponte-Murcia, Hermencia C.

; Guerrero, Manuela

; Giraldo, Andrea

; Villarraga, Laura

; Orjuela, Laura

; Hernández, Juan

; Giraldo-Cadavid, Luis F.

Brazilian Journal of Infectious Diseases

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2024, Volume 28 Nº 4 elocation 103852

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: The primary aim of this study is to assess the survival rates of individuals diagnosed with Community-Acquired Pneumonia (CAP) post-hospitalization in Colombia. Additionally, explore potential risk factors associated with decreased long-term survival. Methods: A retrospective cohort study was conducted in a hospital in Colombia, evaluating survival at 3, 6 and 12 months in CAP patients, using the Kaplan-Meier method. Stratifications were made by age, sex, comorbidity, and severity. The comparison of survival curves was performed using the Log-Rank test, a multivariate analysis with Cox regression was performed to study possible risk factors that affected 12-month survival in patients with CAP. Results: 3688 subjects were admitted, with a mortality of 16.3 % per year. Survival at three, six, and twelve months was 92.9 % (95 % CI 92–93 %), 88.8 % (95 % CI 87–90 %), and 84.2 % (95 % CI 82–85 %), respectively. Analysis stratified by pneumonia severity index, 12-month survival was 98.7 % in Class I, 95.6 % in Class II, 87.41 % in Class III, 77.1 % in Class IV, and 65.8 % in class-V (p < 0.001). Cox-regression showed that being male (HR = 1.44; 95 % CI 1.22–1.70; p < 0.001), an elevated pneumonia severity index (HR = 4.22; 95 % CI 1.89–9.43; p < 0.001), a high comorbidity index (HR = 2.29; 95 % CI 1.89–2.84; p < 0.001) and vasopressor requirement (HR = 2.22; 95 % CI < 0.001) were associated with a lower survival at twelve months of follow-up. Conclusion: Survival in patients with CAP who require hospitalization decreases at 3, 6, and 12 months of follow-up, being lower in patients older than 65 years, men, high comorbidity, and in subjects with severe presentation of the disease. Background CommunityAcquired Community Acquired (CAP posthospitalization post Colombia Additionally longterm long term Methods 3 1 KaplanMeier Kaplan Meier method age sex LogRank Log Rank test 12month month Results 368 admitted 163 16 16. year three six 929 92 9 92. (9 9293 93 92–9 %, , %) 888 88 8 88. 8790 87 90 87–9 842 84 2 84. 8285 82 85 82–8 respectively 987 98 7 98. I 956 95. II 8741 41 87.4 III 771 77 77. IV 658 65. classV class V 0.001. 0001 0.001 . 0 001 Coxregression HR 1.44 144 44 1.22–1.70 122170 22 70 0.001, 4.22 422 4 1.89–9.43 189943 89 43 2.29 229 29 1.89–2.84 189284 2.22 222 followup. followup follow up. up follow-up Conclusion followup, up, years men disease 36 ( 92– 879 87– 828 82– 874 87. 000 0.00 00 1.4 14 1.22–1.7 12217 4.2 42 1.89–9.4 18994 2.2 1.89–2.8 18928 0.0 1. 1.22–1. 1221 4. 1.89–9. 1899 2. 1.89–2. 1892 0. 1.22–1 122 1.89–9 189 1.89–2 1.22– 1.89– 18 1.22 1.89 1.2 1.8

https://doi.org/10.1016/j.bjid.2024.103852

Third National Registry of Cardiac Rehabilitation Programs in Mexico (RENAPREC III-2022)
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Lara-Vargas, Jorge A.

; Ilarraza-Lomelí, Hermes

; García-Saldivia, Marianna

; Pineda-García, Alfredo D.

; Leyva-Valadez, Eduardo A.

; Justiniano-Cordero, Samuel

; Sahagún-Olmos, Roberto

; Zavala-Ramírez, Juana

; Cassaigne-Guasco, María E.

; Sánchez-Limón, Edgar-F

; Castañeda-López, Javier

; Cerón-Enríquez, Norma

; Ku-González, Andrés

; Arteaga-Martínez, Rodolfo

; Hinojosa-López, Tania

; Vergara-Guzmán, Jéssica

; Pérez-Vázquez, Daniel I.

; Gasca-Zamudio, Pedro D.

; Aranda-Ayala, Zulema L.

; Vacío-Reyes, Martha E.

; Reza-Orozco, Marco

; Alcocer-Gamboa, Miguel A.

; Hernández-González, Pedro A.

; Pérez-Reyes, Angélica A.

; Núñez-Urquiza, Juan P.

; Alonso-Sánchez, Jesús

; Franco-Valles, Sarahí

; Romo-Escamilla, Ricardo E.

; Nuriulú-Escobar, Patricia

; Serna-Santamaría, Iván

; Avilés-González, Jorge

; Salgado-Solorio, María C.

; Muñoz-Gutiérrez, Luz M.

; Mendoza-Díaz, Pedro M.

; Ávila-Estrada, Ángel

; Morales-Medina, Carlos

; Lara-Vázquez, Eduardo

; Rodríguez-Herrera, Paulina

; Galván-López, María

; Segoviano-Mendoza, Georgina

; De-la-Torre-Cruz, Fabiola

; Jiménez-Campos, Cecilia

; Ramírez-Meléndez, Alejandra

; Almaraz-Ríos, Alejandro

; González-Bonilla, Mezthly

; Rojano-Castillo, Jessica

; Rius-Suarez, María D.

Archivos de cardiología de México

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Dez 2023, Volume 93 Nº 4 Páginas 405 - 416

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

resumen está disponible en el texto completo

Abstract Introduction: In Mexico, cardiac rehabilitation (CR) as an interdisciplinary intervention with therapeutic impact in patients with heart disease is growing. There is the need to know actual conditions of CR in our country. Objectives: The objective of this National Registry is to follow-up those existing and new CR units in Mexico through the comparison between the two previous registries, RENAPREC-2009 and RENAPREC II-2015 studies. This is a descriptive study focused on diverse CR activities such as assistance training, and certification of health professionals, barriers, reference, population attended, interdisciplinarity, permanence over time, growth prospects, regulations, post-pandemic condition, integrative characteristics, and scientific research. Results: Data were collected from 45 CR centers in the 32 states, 75.5% are private practice units, 67% are new, 33% were part of RENAPREC II-2015, and 17 have continued since 2009. With a better distribution of CR units along the territory, the median reference of candidates for CR programs is 9% with a significant reduction into tiempo of enrollment to Phase II admission (19 ± 11 days). Regarding to previous registries, the coverance of Phases I, II, and III is 71%, 100%, and 93%, respectively; and a coverance increases in evaluation, risk stratification, and prescription, more comprehensive attendance and prevention strategies. Conclusions: CR in Mexico has grown in the past 7 years. Even there is still low reference and heterogeneity in specific processes, there are strengths such as interdisciplinarity, scientific professionalization of specialists, national diversification, and an official society that are consolidated over time.

https://doi.org/10.24875/acm.22000235

Challenges in prosthetic valvular thrombosis: imaging relevance and the decision-making process
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Herrera-Céspedes, Cristhian E.

; Giraldo, Santiago

; Saavedra, Yesid

; Vélez, Luis A.

; Hernández, José A.

; López, Nilson

; Chavarriaga, Juan C.

Archivos de cardiología de México

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Dez 2023, Volume 93 Nº 4 Páginas 502 - 503

Resumo: En | Texto: En | PDF: En

https://doi.org/10.24875/acm.22000193

Anomalous origin of the right pulmonary artery in a young man with Eisenmenger syndrome
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Plata-Corona, Juan C.

; Hernández-González, G. Lisseth

; Candia-Ramírez, Manuel A.

; Sierra-Lara, Jorge D.

; Arenas-Díaz, José O.

Archivos de cardiología de México

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Dez 2023, Volume 93 Nº 4 Páginas 510 - 513

Resumo: En | Texto: En | PDF: En

https://doi.org/10.24875/acm.22000201

Effect of extracts of Citrus sinensis (Rutaceae) and Trichilia havanensis (Meliaceae) in mortality and repellence of Tetranychus urticae (Acari: Tetranychidae)
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Rivera-Hernández, Mitchel

; Luna-Guevara, Juan José

; Aragón-García, Agustín

; Pérez-Torres, Betzabeth Cecilia

; López-Olguin, Jesús F.

Biotecnia

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Dez 2023, Volume 25 Nº 3 Páginas 154 - 161

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Este trabajo tuvo como objetivo evaluar el efecto de los extractos de pericarpio de Citrus sinensis y semillas de Trichilia havanensis en la mortalidad y repelencia de diferentes estados biológicos de Tetranychus urticae en condiciones de laboratorio. Soluciones preparadas con los extractos en concentraciones de 500, 1000 y 1500 mg•L-1fueron aplicadas a un número conocido de huevos, larvas y hembras adultas de T. urticae en discos foliares de frijol (Phaseus vulgaris L.). El análisis de los datos del porcentaje mortalidad y repelencia (prueba de Kruskal Wallis (α = 0.05)) mostraron que el extracto de T. havanensis ocasionó la mortalidad de huevos más alta con el 45 % a 1500 mg•L-1, el extracto de C. sinensis presentó el mayor porcentaje de mortalidad en larvas y adultos con el 40.0 % a 1000 mg•L-1 y 50.0 % a 1500 mg•L-1, respectivamente. El extracto de C. sinensis mostró el mayor porcentaje de repelencia con el 30.0 % en larvas y 60.0 % en adultos a 1500 mg•L-1. Los resultados indican que los extractos tienen el potencial para desarrollar productos efectivos en el manejo de T. urticae.

Abstract This work aimed to evaluate the effect of the plant extract from Citrus sinensis peel and Trichilia havanensis seeds, on mortality and repellency in different biological states of Tetranychus urticae under laboratory conditions. Solutions of the extracts at 500, 1000, and 1500 mg•L-1 were applied to a known number of eggs, larvae, and female adults of T. urticae in foliar discs of bean (Phaseolus vulgaris L.). The data analysis of mortality percentage and the repellence (Kruskal-Wallis test and comparison of medians, α = 0.05) showed that the T. havanensis extract presented the highest percentage of mortality in eggs with 45.0 % at 1500 mg•L-1, and the C. sinensis extract presented the highest mortality in larvae with 40.0 % at 1000 mgL-1 and adults with a 50.0 % at 1500 mg•L-1. The highest percentage of repellency was the C. sinensis extract at 1500 mg•L-1, with 30.0 % in larvae and 60.0 % in adults. The results indicate that the extracts have the potential to develop effective products for managing T. urticae.

https://doi.org/10.18633/biotecnia.v25i2.2107

Arbustivas y arbóreas del piedemonte amazónico colombiano: potencial nutricional y ambiental en sistemas ganaderos
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Narváez-Herrera, Juan Pablo

; Angulo-Arizala, Joaquín

; Barragán-Hernández, Wilson

; Mahecha-Ledesma, Liliana

Agronomía Mesoamericana

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Dez 2023, Volume 34 Nº 3 elocation 52442

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción. Los sistemas ganaderos del piedemonte amazónico se caracterizan por una baja eficiencia en el uso del suelo, predominio de monocultivos de gramíneas y disminución significativa de la cobertura arbórea, que sumado a la contribución de gases de efecto invernadero, relacionan la actividad ganadera con el calentamiento global. Objetivo. Recopilar y analizar resultados de investigaciones sobre las especies Erythrina poeppigiana (Walp.) O.F. Cook, Clitoria fairchildiana R.A. Howard, Piptocoma discolor (Kunth) Pruski y Guazuma ulmifolia Lam. Desarrollo. Mediante el uso de Google Scholar, fórmulas de búsqueda y términos claves asociados al objetivo del estudio, se recuperaron y analizaron 97 documentos. Para las especies de interés, se reportó un amplio rango de adaptación ambiental (0 - 1600 m s. n. m. y entre 1000 y 3700 mm precipitación/año), con potencial para desarrollarse en suelos mal drenados y con bajo pH. Su uso se asoció a cercas vivas, bancos forrajeros, consumo en pastoreo, entre otros. Asimismo, se reportaron valores de materia seca entre 23 y 35 %, proteína cruda entre 15 y 21 % y FDN y FDA <60 % y <45 %, respectivamente. También se encontraron reportes de metabolitos secundarios como taninos y saponinas, lo que podría relacionarse con un potencial para mitigar metano entérico. Se analiza la inclusión de estas especies de plantas forrajeras o similares, por tener un impacto positivo en el almacenamiento de carbono y restauración de áreas degradadas, dadas sus implicaciones en el suelo como fijación de nitrógeno (leguminosas) y aporte de nutrientes vía hojarasca. Conclusiones. Por sus características nutricionales, adaptación y perfil fitoquímico, sería pertinente evaluar el comportamiento de las especies E. poeppigiana, C. fairchildiana, P. discolor y G. ulmifolia, como estrategia para mejorar la oferta nutricional y disminuir las emisiones de metano entérico en condiciones de piedemonte amazónico.

Abstract Introduction. The Amazon foothills livestock is characterized by inefficient land use, pasture monoculture, and significant reduction of the forest, which added to greenhouse gas emissions; it correlates the livestock practices to climate change. Objective. To compile and analyze research on Erythrina poeppigiana (Walp.) O.F. Cook, Clitoria fairchildiana R.A. Howard, Piptocoma discolor (Kunth) Pruski and Guazuma ulmifolia Lam. Development. Through the use of Google Scholar, search algorithms, and keywords 97 papers related to this study were found and analyzed. To the forage shrubs of interest, the review reported a wide environmental range of adaptation (0 - 1600 m a. s. l. and between 1000 and 3700 mm rain/year), with the potential to develop in poorly drained soils and with low pH. The use of these shrubs in livestock was related to living fences, fodder banks, and direct intake, among others. Likewise, the literature review reported a dry matter concentration between 23 and 35 %, crude protein between 15 % and 21 %, and NDF and ADF <60 % and <45 %, respectively. Additionally, reports of secondary plant metabolites like tannins and saponins were also found, which could be related to the reduction of enteric methane. Lastly, the review examines the potential effect on carbon storage and land restoration by including the shrubs species discussed in the present study due to the possible effect on nitrogen fixation (legumes) and soil nutrient restoration via litter decomposition. Conclusions. Due to their nutritional characteristics, wide range of adaptation, and phytochemical profile, it would be pertinent to evaluate the behavior of the species E. poeppigiana, C. fairchildiana, P. discolor, and G. ulmifolia, as a strategy to improve nutrition and reduce methane emission in the Amazon foothills livestock farming.

https://doi.org/10.15517/am.2023.52442

Litotricia intravascular en el manejo de la enfermedad arterial periférica. Revisión de la literatura y reporte de caso
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Aguilar-Garay, Víctor A.

; Moreno-Rojas, Juan C.

; Fabián-Mijangos, Wenceslao

; Hernández-López, Dámaso

; Casares-Bran, Teresa M.

Revista mexicana de angiología

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Set 2023, Volume 51 Nº 3 Páginas 93 - 100

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen La enfermedad arterial periférica (EAP) involucra una gran variedad de patologías en la circulación arterial, siendo la enfermedad ateroesclerótica oclusiva la principal causa. En pacientes en estadios más avanzados de la EAP se considera la revascularización de la zona afectada como tratamiento a seguir del manejo médico. Como una opción en el manejo endovascular tenemos la preparación del vaso para los distintos grados de calcificación. La litotricia intravascular (LIV), basada en la litotricia extracorpórea para la litiasis renal, es de recién incorporación al arsenal disponible para el tratamiento endovascular útil, mejorando la distensibilidad luminal y facilitando el tratamiento endovascular. Este ha demostrado una reducción significativa del grado de estenosis residual (≤ 30%), una menor tasa de complicaciones (1.4 frente a 6.8% en angioplastia) y menor necesidad de uso de angioplastia medicada o stent para mantener permeable el vaso tratado (LIV 5.2 y 4.6% comparado con 17 y 18.3%). Se presenta el caso de un paciente con EAP TASC C en quien se realizó LIV para tratamiento de la lesión, presentando un buen éxito técnico y clínico.

Abstract Peripheral arterial disease (PAD) involves a wide variety of pathologies that affects the arterial circulation, being the atherosclerotic occlusive disease the main cause. In patients in more advanced stages of PAD, revascularization of the affected area is considered a treatment to follow medical management. As an option in endovascular management, we have the preparation of the vessel for the different degrees of calcification. Intravascular lithotripsy (IVL), based on extracorporeal lithotripsy for renal lithiasis, is a recent addition to the arsenal available for useful endovascular treatment, improving luminal distensibility and facilitate endovascular treatment, it has shown a significant reduction in the degree of residual stenosis (≤ 30%), a lower rate of complications (1.4 vs. 6.8% in angioplasty) and less need for the use of medicated angioplasty or stent to keep the treated vessel patent (LIV 5.2 and 4.6% compared to 17 and 18.3%). It is presented the case of a patient with TASC C PAD who underwent IVL, with good technical and clinical success.

https://doi.org/10.24875/rma.22000034

10.

Phytochemical Compounds from Xcatik (Capsicum annuum L.) Chili Tissues Extracted by Uae: Biological Activity and Phenolic Profile
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Pacheco, Neith

; Herrera-Pool, Emanuel

; Castañeda-Valbuena, Daniel

; Cuevas-Bernardino, Juan C.

; Castillo-Aguilar, Crescencio C.

; Andueza-Noh, Rubén

; Garruña-Hernández, René

; Ramos-Diaz, Ana

; Ayora-Talavera, Teresa

Journal of the Mexican Chemical Society

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Set 2023, Volume 67 Nº 3 Páginas 200 - 212

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract. Phenolic compounds and capsaicinoids present in different tissues (placenta, pericarp, and seeds) of the chili pepper fruit Capsicum annuum L. (cv. xcatik) cultivated in the Yucatán peninsula (Mexico) were analyzed. For this purpose, fresh and dehydrated chili peppers tissues were used. The phenolic compounds and capsaicinoids were extracted using ultrasound-assisted extraction (UAE) and compared to the maceration method. Extracts from each fruit tissue were studied for their antioxidant properties, and a phenolic profile of the whole fruit was performed using ultra-high-performance liquid chromatography with a photodiode array detector coupled to mass spectrometry (UPLC-PAD-ESI-MS). The xcatik chili pepper (XCP) presented a high content of phenolic compounds (11.67±3.34 mg GAE/g DW). The capsaicin:dihydrocapsaicin ratio was 2:1. Additionally, 17 phenolic compounds were detected in the extract of the whole fruit. This study provides a first scan of the phenolic composition and capsaicinoids content of the different tissues of the XCP fruit, as well as the correlation of these bioactive compounds with the antioxidant capacity, highlighting the recovery of bioactive compounds with great antioxidant power.

Resumen. El contenido de compuestos fenólicos y capsaicinoides presentes en diferentes tejidos (placenta, pericarpio y semilla) de los frutos de chile Capsicum annuum L. (cv. xcatik) cultivados en la península de Yucatán (Mexico) fue analizado. Para dicho propósito, los tejidos frescos y deshidratados fueron evaluados. Los compuestos fenólicos y los capsaicinoides fueron extraídos usando la Extracción Asistida por Ultrasonido (EAU) y comparados con el método de maceración. Los extractos de cada tejido del fruto fueron estudiados con relación a sus propiedades antioxidantes, y el perfil fenólico del fruto completo fue realizado usando cromatografía líquida de ultra alta resolución con un detector de arreglo de fotodiodos y acoplado a espectrometría de masas (UPLC-PAD-ESI-MS). El chile xcatik (XCP) demostró ser un fruto con alto contenido de compuestos fenólicos (11.67±3.34 mg GAE/g peso seco). La relación capsaicina:dihidrocapsaicina fue 2:1. Adicionalmente, la presencia de 17 compuestos fenólicos fue detectada en el extracto del fruto completo. Este estudio proporciona un primer barrido de la composición fenólica y el contenido de capsaicinoides de los diferentes tejidos del fruto XCP, así como la correlación de estos compuestos bioactivos con la actividad antioxidante, resaltando la recuperación de compuestos bioactivos con un alto poder antioxidante.

https://doi.org/10.29356/jmcs.v67i3.1970

11.

Frequency of delirium and associated factors in patients from a neurological emergency department
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Violante-Villanueva, Jesús A.

; Lázaro-Jarquín, Moisés E.

; Ramírez-Bermúdez, Jesús

; Martínez-Angeles, Victoria

; Galnares-Olalde, Javier A.

; Carrillo-Loza, Karina

; Martínez-Piña, Arturo

; García Salazar, Xiomara

; López-Hernández, Juan C.

Revista mexicana de neurociencia

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Ago 2023, Volume 24 Nº 4 Páginas 102 - 108

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: El delirium es una causa importante de morbi-mortalidad en la población general hospitalizada. Poca información existe sobre factores de riesgo en población con enfermedad neurológica. Objetivo: Analizar factores de riesgo para delirium en pacientes que acuden a un servicio de urgencias neurológicas. Métodos: Estudio observacional de cohorte prospectivo. Incluimos a todos los pacientes con enfermedad neurológica, ingresados al servicio de urgencias con estancia mayor a 8 horas, en el periodo de tiempo enero a abril de 2022. A todos los pacientes se les aplicó el instrumento para detección de delirium CAM-ICU y/o criterios DSM-5. Obtuvimos información de variables epidemiológicas, clínicas y paraclínicas al momento del ingreso. A través de un modelo de regresión logística univariable y multivariable analizamos factores de riesgo para delirium. Resultados: De 3661 pacientes atendidos en el periodo de tiempo señalado, 189 pacientes fueron incluidos, 60.8% género masculino, edad 48 ± 19 años; 44 (23.2%) cumplieron criterios para delirium, 81% fue diagnosticado al ingreso; puntuación en escala delirium/Index 12 (RIQ 10-12), duración de delirium 5 (RIQ2-11) días. Antecedentes clínicos para riesgo de delirium: delirium previo (OR 3.9, IC 95% 2.4-6.1, p = 0.003), EVC (OR 2.2, IC 95% 1.4-3.9, p = 0.009), neurocirugía (OR 2.1, IC 95% 1.2-3.8, p = 0.024) y uso de drogas psicoactivas (OR 2.5, IC 95% 1.3-4.6, p = 0.021). A través del modelo de regresión logística multivariable, los siguientes factores de riesgo son independientes para delirium: epilepsia descontrolada OR 5.4 (IC 95% 1.2-22.9), p = 0.023; lesión cerebral estructural supratentorial OR 6,1 (IC 95% 1.7-21.2), p = 0.004; neuroinfección OR 9.6 (IC 95% 2.9-31.4), p ≤ 0.001. Conclusiones: La frecuencia de delirium es de 23.2% en pacientes en el servicio de urgencias neurológicas; epilepsia descontrolada, neuroinfeccion y lesiones cerebrales supratentoriales son factores de riesgo independientes para delirium.

Abstract Background: Delirium is an important cause of morbidity and mortality in the general hospitalized population. Few information exists on risk factors in patients with neurological disease. Objective: This study was to analyze risk factors for delirium in patients presenting to a neurological emergency department. Methods: This study was observational prospective cohort study. We included all patients with neurological disease, admitted to the emergency department with a stay of more than 8 h, in the period from January to April 2022. The confusion assessment method-intensive care unit delirium detection instrument and DSM-5 criteria were applied to all patients. We obtained information on epidemiological, clinical, and paraclinical variables at the time of admission. Through a univariate and multivariate logistic regression model, we analyzed risk factors for delirium. Results: Of 3661 patients treated in the emergency department, 189 patients were included, 60.8% male gender, age 48 ± 19 years; 44 (23.2%) met criteria for delirium, 81% were diagnosed on admission; delirium scale score/index 12 (interquartile range [IQR] 10-12), and duration of delirium 5 (IQR 2-11) days. Clinical history for risk of delirium: previous delirium (odds ratio [OR] 3.9, 95% CI 2.4-6.1, p = 0.003), stroke (OR 2.2, 95% CI 1.4-3.9, p = 0.009), neurosurgery (OR 2.1, 95% CI 1.2-3.8, p = 0.024), and use of psychoactive drugs (OR 2.5, CI9 5% 1.3-4.6, p = 0.021). The following variables were independent risk factors for delirium through the multivariate logistic regression model:uncontrolled crisis [OR 5.4 (95% CI 1.2-22.9), p = 0.023], supratentorial structural brain lesion [OR 6.1 (95% CI 1.7-21.2), p = 0.004], and neuroinfection OR 9.6 (95% CI 2.9-31.4), p ≤ 0.001]. Conclusions: The frequency of delirium is 23.2% in patients presenting to the neurological emergency department; uncontrolled epilepsy, neuroinfection, and supratentorial brain lesions are independent risk factors for delirium.

https://doi.org/10.24875/rmn.22000083

12.

Síndrome de Guillain-Barré antes y durante la pandemia de COVID-19 en un centro de referencia de México
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López-Hernández, Juan C.

; Vargas-Cañas, Edwin S.

; Estrada, S. Alexander

; Galnares-Olalde, Javier

Gaceta médica de México

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Ago 2023, Volume 159 Nº 4 Páginas 322 - 328

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Antecedentes: Durante la pandemia de COVID-19 se ha reportado incremento de casos de síndrome de Guillain-Barré (SGB). Objetivo: Describir características clínicas y pronóstico de pacientes con SGB antes y durante la pandemia de COVID-19. Material y métodos: Cohorte prospectiva de pacientes con SGB estratificados en dos subgrupos: antes (2018-2019) y durante (2020-2021) la pandemia de COVID-19. Se registraron características clínicas, paraclínicas y defunciones. Se definió como buen pronóstico a la recuperación de la marcha independiente a los tres meses. Resultados: Se incluyeron 201 pacientes (123 durante la pandemia y 78 antes), 69 % del sexo masculino, edad de 45 ± 16 años, 2.5 % de muertes intrahospitalarias. Durante la pandemia se observó mayor frecuencia de la variante desmielinizante (50 %), afección de nervios craneales bulbares (44 % versus 28 %), antecedente de vacunación (16 % versus 0 %) y menor puntuación en la escala MRC (30 ± 16.7 versus 34.3 ± 17.7); se observó aumento de casos de julio a septiembre (38 versus 13). No existieron diferencias significativas en la recuperación de la marcha independiente y número de defunciones. Conclusiones: Durante la pandemia se atendió mayor número de casos de SGB, 16 % asociado a la vacuna contra SARS-CoV-2; los pacientes no presentaron peor pronóstico.

Abstract Background: During the COVID-19 pandemic, an increase in the number of Guillain-Barre syndrome (GBS) cases has been reported. Objective: To describe the clinical characteristics and prognosis of patients with GBS before and during the COVID-19 pandemic. Material and methods: Prospective cohort of GBS patients divided in two subgroups: before (2018-2019) and during (2020-2021) the COVID-19 pandemic. Clinical and paraclinical characteristics, as well as deaths, were recorded. A good prognosis was defined as independent ambulation recovery at three months. Results: Two-hundred and one patients were included (123 during and 78 before the pandemic), out of whom 69 % were males; age was 45 ± 16 years, and there was 2.5 % of in-hospital deaths. During the pandemic, a higher frequency of the demyelinating variant (50 %), bulbar cranial nerves involvement (44 % vs. 28 %), prior history of vaccination (16 % vs. 0 %), and a lower MRC score (30 ± 16.7 vs. 34.3 ± 17.7) were documented. An increase in the number of cases was observed from July to September (38 vs. 13). There were no significant differences in independent ambulation recovery or in the number of deaths. Conclusions: During the COVID-19 pandemic, a higher number of GBS cases were treated, out of which 16 % were associated with the SARS-CoV-2 vaccine; patients treated during the pandemic did not have a worse prognosis.

https://doi.org/10.24875/gmm.23000114

13.

Geotechnical aspects of drilling and excavation of volcanic terrain for groundwater exploitation
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Santamarta, Juan C.

; Hernández-Gutiérrez, Luis E.

; Lario-Báscones, Rafael J.

; Rodríguez-Martín, Jesica

; Cruz-Pérez, Noelia

REM - International Engineering Journal

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Jun 2023, Volume 76 Nº 2 Páginas 203 - 210

Resumo: En | Texto: En | PDF: En

Abstract Heterogeneity of volcanic materials that constitute the Canary Islands (Spain) means that mining work in water galleries excavated on these islands, drilling into the terrain for many kilometres, is very challenging. They are composed of materials that vary significantly in terms of cohesion, ranging from very consolidated to loose and highly unstable. Water galleries have been key in the development of the Canary Islands, in order to obtain drinking water from the aquifer. Generally, aquifers are located in mountainous areas with difficult access, which complicates the drilling work. This article analyses the main geotechnical problems encountered in the construction of subterranean water galleries in the Canary Islands, as well as possible solutions to these problems, so that these can be applied to similar territories. As a general conclusion, the instabilities inherent in volcanic materials affect this type of work, and it is necessary to take specific measures for each type of geotechnical risk, as proposed in this article. Spain (Spain islands kilometres challenging cohesion unstable aquifer Generally access territories conclusion risk

https://doi.org/10.1590/0370-44672021760027

14.

Novel Therapy for Acquired Tracheomalacia with a Tissue-Engineered Extraluminal Tracheal Splint and Autologous Mesenchymal-Derived Chondrocytes TissueEngineered Tissue Engineered MesenchymalDerived Mesenchymal Derived
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Melgarejo-Ramírez, Yaaziel

; Ceballos-Cantú, Juan C.

; Montes-Olave, Eric de J.

; Hernández-Tapia, Bruno

; Rojas-Figueroa, Víctor

; Ramírez-Arroyo, Gabriela

; Cortés-Acosta, Fabiana

; Dorantes-Pavón, Mario

; Lecona-Butrón, Hugo

; Beltrán-Rodríguez-Cabo, Olga E.

International Archives of Otorhinolaryngology

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Jun 2023, Volume 27 Nº 2 Páginas 342 - 350

Resumo: En | Texto: En | PDF: En

Abstract Introduction Acquired tracheomalacia (ATM) is characterized by a loss of structural strength of the tracheal framework, resulting in airway collapse during breathing. Near half of the patients undergoing prolonged invasive mechanical ventilation will suffer tracheal lesions. Treatment for ATM includes external splinting with rib grafts, prosthetic materials, and tracheal resection. Failure in the use of prosthetic materials has made reconsidering natural origin scaffolds and tissue engineering as a suitable alternative. Objective To restore adequate airway patency in an ovine model with surgicallyinduced ATM employing a tissue-engineered extraluminal tracheal splint (TE-ETS). Methods In the present prospective pilot study, tracheal rings were partially resected to induce airway collapse in 16 Suffolk sheep (Ovis aries). The TE-ETS was developed with autologous mesenchymal-derived chondrocytes and allogenic decellularized tracheal segments and was implanted above debilitated tracheal rings. The animals were followed-up at 8, 12, and 16 weeks and at 1-year postinsertion. Flexible tracheoscopies were performed at each stage. After sacrifice, a histopathological study of the trachea and the splint were performed. Results The TE-ETS prevented airway collapse for 16 weeks and up to 1-year postinsertion. Tracheoscopies revealed a noncollapsing airway during inspiration. Histopathological analyses showed the organization of mesenchymal-derived chondrocytes in lacunae, the proliferation of blood vessels, and recovery of epithelial tissue subjacent to the splint. Splints without autologous cells did not prevent airway collapse. Conclusion It is possible to treat acquired tracheomalacia with TE-ETS without further surgical removal since it undergoes physiological degradation. The present study supports the development of tissue-engineered tracheal substitutes for airway disease. (ATM framework breathing lesions grafts resection alternative tissueengineered engineered TEETS. TEETS TE ETS . (TE-ETS) 1 Ovis aries. aries aries) mesenchymalderived mesenchymal derived followedup followed 8 12 1year year postinsertion stage sacrifice inspiration lacunae vessels degradation disease (TE-ETS

https://doi.org/10.1055/s-0042-1746194

15.

Guillain-Barre syndrome with hyponatremia, more than a simple finding
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Martínez-Piña, Daniel A.

; Medina-Gómez, Victor

; García-Hernández, José F.

; Vargas-Cañas, Edwin S.

; Violante-Villanueva, Arturo

; López-Hernández, Juan C.

Revista mexicana de neurociencia

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Jun 2023, Volume 24 Nº 3 Páginas 71 - 77

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción: La hiponatremia se presenta en el 21,5-48% de los pacientes con síndrome de Guillaín-Barré (SGB), sin embargo, existe poca información sobre sus implicaciones clínicas en el SGB. Material y métodos: Se realizó un estudio observacional, transversal, de pacientes con diagnóstico de SGB. Recabamos información de variables clínicas, resultado del LCR y conducción nerviosa. Los pacientes con niveles de sodio < 135 meq/L en estudios de laboratorio al ingreso y antes del inicio de tratamiento fueron considerados con hiponatremia. Definimos buen pronóstico funcional a la presencia de marcha independiente (Hughes ≤ 2 puntos) a los 3 meses de seguimiento. Resultados: De 212 pacientes, 31 (14.6%) presentaron hiponatremia, sexo masculino 72%, edad promedio 45.9 ± 16 años, MRC score 30.1 ± 17 puntos, requerimiento de VMI 32%, presencia de disautonomía 32%. Recabamos ciento ochenta y dos estudios de conducción nerviosa y 165 resultados citoquímicos de punción lumbar. En el análisis comparativo entre los pacientes con hiponatremia vs sin hiponatremia, observamos diferencias significativas: edad (50.4 ± 14,9 vs. 43.8 ± 16.3, p = 0.03), días de hospitalización (mediana) (16 [IQR = 7-51] vs. 7 [IQR = 5-12] p = 0.03), disautonomía (54.8% vs. 28.2%, p = 0.006), niveles de proteínas (mgs/dL) en LCR (mediana) (105 [IQR = 59-165] vs. 39 [IQR = 28-57], p ≤ 0.001) y variante AIDP (70.4% vs. 42%, p = 0.011); En la recuperación de la marcha a los 3 meses, no hubo diferencia significativa (34,6% vs. 42,6%, p = 0.51). Conclusión: 14% de los pacientes con SGB presentan hiponatremia, con formas clínicas más severas, presencia de disautonomía, variante de AIDP más frecuente, niveles elevados de proteínas en LCR y mayor número de días de estancia hospitalaria, pero no afecta el pronóstico funcional.

Abstract Introduction: Hyponatremia occurs in 21-48% of patients with Guillain-Barre syndrome (GBS). However, little is known about the clinical implications in GBS. Materials and methods: In this observational, cross-sectional study, of patients diagnosed with GBS was conducted. Information used included: demographic clinical variables, cerebrospinal fluid (CSF) results, and nerve conduction studies. Patients with sodium levels < 135 meq/L in laboratory studies on admission and before treatment were considered to have hyponatremia. We defined good functional prognosis as the presence of independent gait (Hughes ≤ 2 points) at 3 months of follow-up. Results: Two hundred and twelve patients were initially screen and 31 (14.6%) presented hyponatremia; male gender was predominant with 72%, mean age was 45.9 ± 16 years, mean Modified Medical Research Council (MRC) score was 30.1 ± 17 points, invasive mechanical ventilation requirement was 32%, and the presence of dysautonomia 32%. One hundred and eighty-two nerve conduction studies, and 165 CSF cytochemical samples were collected. In the comparative analyses between the patients with hyponatremia versus without hyponatremia, we observed significant differences in mean age (50.4 ± 14.9 vs. 43.8 ± 16.3, p = 0.03), days of hospitalization (median) (16 [IQR = 7-51] vs. 7 [IQR = 5-12] p = 0.03), dysautonomia (54.8% vs. 28.2%, p = 0.006), protein levels (mgs/dL) in CSF (median) (105 [IQR = 59-165] vs. 39 [IQR = 28-57], p ≤ 0.001), and acute inflammatory demyelinating polyneuropathy (AIDP) variant (70.4% vs. 42%, p = 0.011). There was no significant finding in recovery of independent gait at 3 months (34.6% vs. 42.6%, p = 0.51). Conclusion: About 14% of patients with GBS presented with hyponatremia in our series and is associated with presence of dysautonomia, AIDP variant, elevated CSF protein levels and a greater number of days of hospital stay but did not impact functional prognosis.

https://doi.org/10.24875/rmn.22000081

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