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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Data de publicação: 2024-04-08

Resumo: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Esophageal and gastric pythiosis in a dog
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Silva, Emanoelly Machado Sousa da

; Martins, Kamila Peruchi Fernandes

; Pereira, Asheley Henrique Barbosa

; Gris, Anderson Hentz

; Maruyama, Fernanda Harumi

; Nakazato, Luciano

; Colodel, Edson Moleta

; Oliveira, Luiz Gustavo Schneider de

; Boabaid, Fabiana Marques

Ciência Rural

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2024, Volume 54 Nº 6 elocation e20230272

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: Pythiosis is the disease caused by aquatic oomycetes of the genus Pythium. In dogs the typical course of the disease involves the gastrointestinal tract, characterized by transmural thickening of the stomach or intestines. However, infection by Pythium spp. has only rarely been recognized as a cause of esophagitis in dogs. Thus, the present reports a case of esophageal and gastric pythiosis in an eight-month-old female pit bull dog. The dog was attended at the hospital after two months presenting regurgitation and dyspnea. It was reported that the dog lived in an urban area and had no previous sanitary issues. At clinical examination it was noted that the dog presented crackling sounds at pulmonary auscultation. A support therapy accompanied by antibiotics has been employed; however, 22 days after hospitalization the clinical condition worsened, and the dog died. At necropsy, the wall of the distal segment of the esophagus and the cardia and part of the fundus of the stomach were expanded by a focal extensive irregular intramural annular mass. Additionally, there was a transmural esophageal fistula. At histology, the walls of the esophagus and stomach were extensively expanded by multifocal extensive areas of necrosis, associated with a pyogranulomatous infiltrate and abundant granulation tissue containing multiple negative images of hyphae that were highlighted by silver impregnation (Grocott). Furthermore, immunohistochemistry and PCR for P. insidiosum were both positive in samples of paraffin-embedded esophageal tissue.

RESUMO: A Pitiose é uma doença causada por oomicetos aquáticos do gênero Pythium. Em cães o curso típico da doença envolve o trato gastrointestinal, caracterizado por espessamento transmural do estômago ou intestinos. No entanto, a infecção por Pythium spp. raramente foi reconhecida como causa de esofagite em caninos. Assim, o presente trabalho tem como objetivo relatar um caso de pitiose esofágica e gástrica em um canino Pit Bull fêmea de oito meses de idade. O cão foi recebido no hospital com histórico de regurgitação e dispneia durante dois meses. Foi relatado que o animal era de um domicílio de área urbana e não possuía histórico pregresso de enfermidades. No exame clínico contatou-se ainda crepitações à ausculta pulmonar. Foi instituído tratamento de suporte e antibioticoterapia, porém após 22 dias de internação, o cão evoluiu para o óbito. Na necropsia, as paredes do segmento distal do esôfago e o cárdia e parte do fundo do estômago estavam expandidos por uma massa anular intramural focalmente extensiva e irregular. Além disso, havia uma fístula esofágica transmural. À histologia, as paredes do esôfago e do estômago apresentavam-se difusamente expandidas por áreas multifocais extensas de necrose, associadas a infiltrado piogranulomatoso, abundante proliferação de fibroblastos imaturos, neovascularização e contendo múltiplas imagens negativas de hifas realçadas pela impregnação por prata (Grocott). Além disso, tanto a imuno-histoquímica como PCR para P. insidiosum foram positivas em amostras de esôfago embebidas em parafina.

https://doi.org/10.1590/0103-8478cr20230272

Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023
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Almeida, André Luiz Cerqueira

; Melo, Marcelo Dantas Tavares de

; Bihan, David Costa de Souza Le

; Vieira, Marcelo Luiz Campos

; Pena, José Luiz Barros

; Del Castillo, José Maria

; Abensur, Henry

; Hortegal, Renato de Aguiar

; Otto, Maria Estefania Bosco

; Piveta, Rafael Bonafim

; Dantas, Maria Rosa

; Assef, Jorge Eduardo

; Beck, Adenalva Lima de Souza

; Santo, Thais Harada Campos Espirito

; Silva, Tonnison de Oliveira

; Salemi, Vera Maria Cury

; Rocon, Camila

; Lima, Márcio Silva Miguel

; Barberato, Silvio Henrique

; Rodrigues, Ana Clara

; Rabschkowisky, Arnaldo

; Frota, Daniela do Carmo Rassi

; Gripp, Eliza de Almeida

; Barretto, Rodrigo Bellio de Mattos

; Silva, Sandra Marques e

; Cauduro, Sanderson Antonio

; Pinheiro, Aurélio Carvalho

; Araujo, Salustiano Pereira de

; Tressino, Cintia Galhardo

; Silva, Carlos Eduardo Suaide

; Monaco, Claudia Gianini

; Paiva, Marcelo Goulart

; Fisher, Cláudio Henrique

; Alves, Marco Stephan Lofrano

; Grau, Cláudia R. Pinheiro de Castro

; Santos, Maria Veronica Camara dos

; Guimarães, Isabel Cristina Britto

; Morhy, Samira Saady

; Leal, Gabriela Nunes

; Soares, Andressa Mussi

; Cruz, Cecilia Beatriz Bittencourt Viana

; Guimarães Filho, Fabio Villaça

; Assunção, Bruna Morhy Borges Leal

; Fernandes, Rafael Modesto

; Saraiva, Roberto Magalhães

; Tsutsui, Jeane Mike

; Soares, Fábio Luis de Jesus

; Falcão, Sandra Nívea dos Reis Saraiva

; Hotta, Viviane Tiemi

; Armstrong, Anderson da Costa

; Hygidio, Daniel de Andrade

; Miglioranza, Marcelo Haertel

; Camarozano, Ana Cristina

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Siqueira, Maria Eduarda Menezes de

; Torreão, Jorge Andion

; Rochitte, Carlos Eduardo

; Felix, Alex

Arquivos Brasileiros de Cardiologia

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Dez 2023, Volume 120 Nº 12 elocation e20230646

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230646

SCS453 Noninha and SCS454 Carvoeira - new banana cultivars of the Prata subgroup
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Scherer, Ramon Felipe

; Beltrame, André Boldrin

; Klabunde, Gustavo Henrique Ferrero

; Maro, Luana Aparecida Castilho

; Guimarães, Gelton Geraldo Fernandes

; Sônego, Márcio

; Lichtemberg, Luiz Alberto

Crop Breeding and Applied Biotechnology

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2023, Volume 23 Nº 1 elocation e43412312

Resumo: En | Texto: En | PDF: En

Abstract ‘SCS453 Noninha’ and ‘SCS454 Carvoeira’ are new banana cultivars derived from the subgroup Prata (AAB). In comparison with the latter, ‘SCS453 Noninha’ has a low pseudostem height, 'SCS454 Carvoeira' a high yield and both unchanged fruit characteristics. Both also have increased resistance to Panama wilt and ‘SCS454 Carvoeira’ to Sigatoka.

https://doi.org/10.1590/1984-70332023v23n1c2

Delivery kinetics of natural active agents by PVA hydrogels intended for wound care
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Fernandes, Isis Siqueira

; Saboia, Laís da Costa

; Gonçalves, Vinicius Soares

; da Costa Neto, Jorge Luiz Siqueira

; Moreira, Ana Paula Duarte

; Souza, Natália Dias

; Nascimento, Alexandre Miguel do

; Chaves, Douglas Siqueira de Almeida

; Rosado, Luiz Henrique Guerreiro

; Silva, Leonardo Duarte Batista da

; Bauerfeldt, Glauco Favilla

; Middea, Antonieta

; Oliveira, Renata Nunes

Matéria (Rio de Janeiro)

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2023, Volume 28 Nº 3 elocation e20230071

Resumo: En | Texto: En | PDF: En

ABSTRACT Acute wound dressings can be based on PVA hydrogels, which present many characteristics of an ideal dressing, e.g., fluid uptake, a moisturized environment, etc. The lack of antimicrobial properties leads to the addition of natural active agents. The present work aims to manufacture and compare PVA gels loaded with Barbatimão bark extract, Leucaena bark extract, Aloe vera, and Lavender essential oil. They were characterized by FTIR, swelling tests, SEM, actives release. There were interactions between PVA and the active agents. The addition of Leucaena and Barbatimão increased the PVA ability to swell, but the opposite was found for Aloe vera and Lavender essential oil. PVA-Lavender essential oil samples presented interconnected pores, while samples with essential oil or extracts presented high crystallinity. Lavender essential oil and Aloe vera presented the highest release. The Barbatimão and Leucaena samples’ release may be related to the samples’ swelling, but the initial release of Aloe vera and Lavender samples was diffusion controlled by swelling. Their long-term release was dose-dependent for Aloe vera, while it was a non-Fickian diffusion for Lavender essential oil related to the hydrogel’s relaxation step. There is a synergistic effect when Aloe vera and Lavender essential oil are loaded in PVA hydrogels. hydrogels dressing eg e g e.g. uptake environment etc agents extract FTIR tests SEM swell PVALavender pores crystallinity longterm long term dosedependent dose dependent nonFickian non Fickian hydrogel s step e.g

https://doi.org/10.1590/1517-7076-rmat-2023-0071

Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis
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Pugliesi, Alisson

; Oliveira, Amanda Borges de

; Oliveira, Ana Beatrice

; Xavier, Ricardo

; Mota, Licia Maria Henrique da

; Bertolo, Manoel Barros

; Gonzalez-Gay, Miguel Angel

; Citera, Gustavo

; Carvalho, Luiz Sergio Fernandes de

Advances in Rheumatology

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2023, Volume 63 elocation 30

Resumo: En | Texto: En | PDF: En

Abstract Background Our aim was to compare the efficacy of rituximab, tocilizumab, and abatacept in individuals with rheumatoid arthritis (RA) refractory to treatments with MTX or TNFi agents. Methods We searched 6 databases until January 2023 for phase 2–4 RCTs evaluating patients with RA refractory to MTX or TNFi therapy treated with rituximab, abatacept, and tocilizumab (intervention arm) compared to controls. Study data were independently assessed by two investigators. The primary outcome was considered as achieving ACR70 response. Results The meta-analysis included 19 RCTs, with 7,835 patients and a mean study duration of 1.2 years. Hazard ratios for achieving an ACR70 response at six months were not different among the bDMARDs, however, we found high heterogeneity. Three factors showing a critical imbalance among the bDMARD classes were identified: baseline HAQ score, study duration, and frequency of TNFi treatment in control arm. Multivariate meta-regression adjusted to these three factors were conducted for the relative risk (RR) for ACR70. Thus, heterogeneity was attenuated (I2 = 24%) and the explanatory power of the model increased (R2 = 85%). In this model, rituximab did not modify the chance of achieving an ACR70 response compared to abatacept (RR = 1.773, 95%CI 0.113–10.21, p = 0.765). In contrast, abatacept was associated with RR = 2.217 (95%CI 1.554–3.161, p < 0.001) for ACR70 compared to tocilizumab. Conclusion We found high heterogeneity among studies comparing rituximab, abatacept, and tocilizumab. On multivariate metaregressions, if the conditions of the RCTs were similar, we estimate that abatacept could increase the chance of reaching an ACR70 response by 2.2-fold compared to tocilizumab. Key messages Abatacept could increase the chance of reaching an ACR70 response by 2.2-fold compared to tocilizumab.

https://doi.org/10.1186/s42358-023-00298-z

PARALLELIZATION OF SHORTEST PATH CLASS ALGORITHMS: A COMPARATIVE ANALYSIS
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Souza, Flávio Henrique Batista de

; Abreu, Marcos Henrique Gonçalves

; Trindade, Paulo Ricardo Fonseca

; Fernandes, Gustavo Alves

; Carvalho, Luiz Melk de

; Couto, Braulio Roberto Gomes Marinho

; Rodrigues, Diva de Souza e Silva

Pesquisa Operacional

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2023, Volume 43 elocation e272130

Resumo: En | Texto: En | PDF: En

ABSTRACT The problem of finding the shortest path between a source and a destination node, commonly represented by graphs, has several computational algorithms as an attempt to find what is called the minimum path. Depending on the number of nodes in-between the source and destination, the process of finding the shortest path can demand a high computational cost (with polynomial complexity). A solution to reduce the computational cost is the use of the concept of parallelism, which divides the algorithm tasks between the processing cores. This article presents a comparative analysis of the main algorithms of the shortest path class: Dijkstra, Bellman-Ford, Floyd-Warshall and Johnson. The performance of each algorithm was evaluated considering different parallelization approaches and they were applied on general and open-pit mining databases present in the literature. The experimental results showed an improvement in performance of about 55% on the execution time depending on the chosen parallelization point.

https://doi.org/10.1590/0101-7438.2023.043.00272130

A Web-GIS for decision making to achieve water quality standards of water bodies through collaborative watershed modeling
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Acosta, Eileen Andrea

; Kishi, Regina Tiemy

; Souza, Marcelo Luiz de

; Pereira, Gabriel Henrique de Almeida

; Bleninger, Tobias Bernward

; Fernandes, Cristóvão Vicente Scapulatempo

; Goulart, Camila Bergmann

; Carvalho, João Marcos

; Polli, Bruna Arcie

; Ferreira, Danieli Mara

; Ferreira, Arthur Humberto Rocha

; Nowatzki, Alexei

; Lassen, Alana Louise Werneck

RBRH

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2023, Volume 28 elocation e29

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Ensuring compliance with the minimum Water Quality Standards stipulated by law demands the implementation of strategic measures within the watershed. Water pollution modeling serves as a tool to guide the formulations of effective pollution control strategies. However, the inherent complexity of calibration, spatial-temporal variability, and uncertainty, in addition to effective communication of technical information to decision makers, makes it challenging to prioritize actions, implement them, and allocate resources efficiently. This paper presents the implementation of a Web-GIS for decision making support which combines collaborative hydrological and hydrodynamic modeling results with an interactive visualization of the Paranapanema river basin in the South of Brazil. The Web-GIS aimed to overcome the difficulty of presenting scientific results to decision-makers, gathering and harmonizing diverse datasets. Combining information from the watershed, the pollutant loads estimations for three substances (phosphorus, nitrogen, and BOD), the resulting concentrations in rivers and reservoirs, as well as the results for different future scenarios into a unified platform. It is expected that decision-making regarding water bodies framework will be facilitated by identifying the primary sources and pathways of pollution, prioritizing basins with the highest load production, an determining realistic possibilities of load reduction through effective measures.

RESUMO Garantir o cumprimento dos padrões mínimos de qualidade de água estabelecidos por lei exige medidas estratégicas na bacia afluente. A modelagem da poluição de água serve como ferramenta para orientar a formulação de estratégias eficazes de controle de poluição. No entanto, a complexidade inerente à calibração, à variabilidade espacial-temporal e a incerteza, aliadas ao repasse ineficaz de informações técnicas para os tomadores de decisão, dificultam não apenas a priorização se não a própria efetivação das ações e aplicação dos recursos eficientemente. Sendo assim, este estudo apresenta o desenvolvimento de um Web-GIS que reúne os principais resultados das modelagens hidrológicas para conceder uma visão interativa da bacia do Rio Paranapanema no sul do Brasil. O sistema supera a dificuldade de apresentação de resultados científicos para o gestor, reunindo e harmonizando conjuntos de dados diversos. Combinando informações da bacia hidrográfica, estimativas de carga de poluentes para três substâncias (fósforo, nitrogênio e DBO), as concentrações resultantes em rios e reservatórios, bem como os resultados para diferentes cenários futuros em uma plataforma unificada. Espera-se que a tomada de decisão em relação ao enquadramento de corpos d'água seja facilitada pela identificação das principais fontes e vias de poluição, priorizando as bacias com maior produção de carga e determinando possibilidades realistas de redução da carga por meio de medidas eficazes.

https://doi.org/10.1590/2318-0331.282320230038

Correlation between levels of perceived stress and depressive symptoms in the functional disability of patients with fibromyalgia
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Fernandes, Luiz Gustavo Rachid

; Wenceslau, Carolyn Maria de Geus

; Santos, André Amaro Mamédio dos

; Lima, Diogo Von Gaevernitz

; Dieckmann, Luiz Henrique Junqueira

; Haddad, Michel

; Mansani, Fabiana Postiglione

; Schafranski, Marcelo Derbli

Revista da Associação Médica Brasileira

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2023, Volume 69 Nº 11 elocation e20230690

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to evaluate the factors that are most correlated with the levels of functional disability in patients with fibromyalgia. METHODS: This is a cross-sectional descriptive study in which 42 patients diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology reported their status using the following questionnaires: the Beck Depression Inventory, the Perceived Stress Scale 14, the Revised Fibromyalgia Impact Questionnaire, the Visual Analog Pain Scale, and the Health Assessment Questionnaire. RESULTS: Moderate to severe levels of depression (Beck Depression Inventory: 22.35±10.39), moderate to severe functional disability (Health Assessment Questionnaire: 1.28±0.58), and high levels of stress (Perceived Stress Scale 14: 31.59±10.02) were found. The correlation adjusted by multiple regression as a function of the Health Assessment Questionnaire indicated a negligible to weak positive correlation with perceived stress (r=0.11), while a moderately strong positive correlation was observed with the Visual Analog Pain Scale (r=0.55). Regarding physical exercise, one of the pillars of the treatment, a moderate negative correlation was found with the Health Assessment Questionnaire (r=-0.4). CONCLUSION: The pain levels were moderately influenced by depression severity. The factors most linked to functional disability are due to the pain levels but not to the perception of stress.

https://doi.org/10.1590/1806-9282.20230690

10.

Uso de estufim e de AIB para o enraizamento de miniestacas de Eucalyptus urophylla S. T. Blake × Eucalyptus pellita F. Muell
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Rocha, Fabiana Miranda

; Titon, Miranda

; Fernandes, Sula Janaína de Oliveira

; Santos, Paulo Henrique Rodrigues dos

; Laia, Marcelo Luiz de

; Pena, Claudilene Aparecida Alves

Ciência Florestal

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Set 2022, Volume 32 Nº 3 Páginas 1460 - 1478

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O gênero Eucalyptus possui grande importância em plantios florestais. No entanto, algumas espécies e clones deste gênero apresentam dificuldades no processo de produção de mudas pelo enraizamento de estacas. Algumas alternativas estão sendo utilizadas para contornar a recalcitrância ao enraizamento, como o uso de reguladores de crescimento e a utilização de estufins no minijardim clonal. Este trabalho teve como objetivo avaliar o efeito do tempo de permanência das minicepas sob o estufim e de diferentes concentrações de ácido indol-3-butírico (AIB) no enraizamento de miniestacas de um clone híbrido de Eucalyptus urophylla × Eucalyptus pellita. Foram testadas quatro concentrações de AIB e um tratamento-controle (0, 1.000, 2.000, 4.000 e 8.000 mg L-1) e dois tempos sob estufim (40 e 70 dias). Mudas produzidas com maiores concentrações do AIB apresentaram altura média e diâmetro do coleto superiores àquelas sem a presença da auxina na saída da casa de vegetação. A massa seca da parte aérea apresentou maiores valores para o menor tempo de estufim na saída da casa de vegetação. Maiores concentrações de AIB proporcionaram o aumento do número de miniestacas enraizadas na saída da casa de vegetação e da área de pleno sol. O uso de 8.000 mg L-1 de AIB aumentou o percentual de raízes consideradas ótimas, nos dois tempos de estufim testados, e reduziu a formação de calos, mostrando-se eficiente para o enraizamento em termos gerais, alcançando 95 % na saída da área de pleno sol. O tempo de uso do estufim no minijardim clonal não influenciou significativamente a produção de mudas de Eucalyptus urophylla × Eucalyptus pellita dentro das condições analisadas.

Abstract The genus Eucalyptus has great importance in forest plantations. However, some species and clones of this genus present difficulties in the seedling production process by the rooting cuttings. Some alternatives have been used to overcome the rooting recalcitrance, such as the use of growth regulators and the use of mini-tunnels in the clonal mini-garden. The objective of this work was to evaluate the effect of the permanence time of mini-ceps under the mini-tunnel and of different concentrations of indole-3-butyric acid (IBA) on the rooting of mini-cuttings of a hybrid clone of Eucalyptus urophylla × Eucalyptus pellita. Four IBA concentrations and a control treatment (0, 1.000, 2.000, 4.000 and 8.000 mg L-1) and two times in a mini-tunnel (40 and 70 days) were tested. The seedlings produced with higher concentrations of AIB presented mean height and root collar diameter greater than those without the presence of auxin at the exit of the greenhouse. The dry mass of the aerial part presented higher values for the shortest period of mini-tunnel at the exit of the greenhouse. Higher IBA concentrations provided an increase in the number of mini-cuttings rooted at the exit of the greenhouse and area under full sun. The use of 8.000 mg L-1 of IBA increased the percentage of roots considered optimal, in the two tested mini-tunnel times, and reduced the callus formation, being efficient for rooting in general terms, reaching 95 % at the exit of the area under full sun. The time of use of the greenhouse in the clonal mini-garden did not significantly influence the production of Eucalyptus urophylla × Eucalyptus pellita seedlings under the conditions analyzed.

https://doi.org/10.5902/1980509865873

11.

Fantastic Lifestyle Questionnaire applied to undergraduate medical students during the COVID-19 pandemic: a factor analysis
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Martins, João Mateus Silva

; Ferreira, Esther Angélica Luiz

; Valete, Cristina Ortiz Sobrinho

; Gramasco, Hendrick Henrique Fernandes

Revista da Associação Médica Brasileira

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Mai 2022, Volume 68 Nº 5 Páginas 658 - 663

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: To identify what structure represents life style in medical students, in a public university, with the application of the Fantastic Lifestyle Questionnaire. METHODS: This is a cross-sectional exploratory study. The Fantastic Lifestyle Questionnaire was applied online to medical students. Factorial analysis was realized and factors were extracted by principal components method. Rotation was conducted by Varimax method. RESULTS: Sixty-one questionnaires were analyzed. Students were male in 45.9%, single in 88.5%. The model was composed of three factors that explained 63.5% of all observed variance. The factors related to sleep perception, nutrition and stress, followed by relationships and entertainment and then, activity. Cronbach's alpha was 0.81, which was considered good. CONCLUSION: The model composed by the three factors observed in this group of students represented the construct quality of life, evaluated by the Fantastic Lifestyle Questionnaire. This result may provide substrate to actions that aim to improve quality of life and well-being in medical students from this university.

https://doi.org/10.1590/1806-9282.20220026

12.

Experimental resin-based dual-cured calcium aluminate and calcium titanate materials for vital pulp therapy
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Vieira, Fabiano Paiva

; Gonini Júnior, Alcides

; Piva, Evandro

; Oliveira, Héllen de Lacerda

; da Rosa, Wellington Luiz de Oliveira

; da Silva, Adriana Fernandes

; Vitti, Rafael Pino

; Zanchi, Cesar Henrique

; Cava, Sergio da Silva

Brazilian Oral Research

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2022, Volume 36 elocation e037

Resumo: En | Texto: En | PDF: En

Abstract: This paper evaluates the physicochemical and biological properties of experimental resin-based dual-cured calcium aluminate (CA) and calcium titanate (CTi) materials for vital pulp therapy (VPT). The experimental dual-cured materials were obtained as two pastes: a) Bis-EMA 10, PEG 400, DHEPT, EDAB, camphorquinone, and butylated hydroxytoluene; and b) fluoride ytterbium, Bis-EMA 10, Bis-EMA 30, benzoyl peroxide, and butylated hydroxytoluene. The materials were divided into six groups based on the added calcium component: MTA (MTA®, Angelus); CLQ (Clinker-Fillapex®, Angelus); CA (calcined at ,1200°C in pastes a and b); CA800 (calcined at 800°C in paste a); CA1200 (calcined at 1,200°C in paste a); and CTi (paste a). The real-time degree of conversion and rate of polymerization (n = 3), diametral tensile strength (n = 10), hydrogen potential (n = 15), calcium ion release (n = 10), water sorption and solubility (n = 10), and cell viability (n = 6) were evaluated. One- and two-way ANOVA and Tukey’s post hoc test were used in the analysis of the parametric data, and Kruskal-Wallis and Dunn’s multiple tests were used to analyze the nonparametric data (α = 0.05). CLQ, CA800 and CA1200 had the highest diametral tensile strength. The water solubility of MTA was similar to that of CA800, CA1200 and CTi. CA800 and CA1200 resulted in cell viabilities similar to those of MTA and CLQ. The experimental dual-cured CA-based material that calcined at 800°C showed physicochemical and biological properties suitable for VPT, and similar to those of MTA.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0037

13.

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings
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ROSSATO, Tharsis Christini de Almeida

; ALVES, Tomaz

; CUEVAS-SUÁREZ, Carlos Enrique

; ROSA, Wellington Luiz de Oliveira da

; SILVA, Adriana Fernandes da

; PIVA, Evandro

; ZANCHi, Cesar Henrique

; LUND, Rafael Guerra

Brazilian Oral Research

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2022, Volume 36 elocation e091

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to formulate an experimental light-cured periodontal dressing containing alpha-humulene and to compare its physical, antimicrobial, and cytotoxicity properties with commercial gold standards (Barricaid® and Periobond®). Two periodontal dressing formulations were developed (a and b). The formulations were divided into 5 groups according to the alpha-humulene concentration as follows: Ea - control group, Ea1 - 1%, Ea5 - 5%, Ea10 - 10%, and Ea20 - 20%; Eb - control group, Eb1 - 1%, Eb5 - 5%, Eb10 - 10%, and Eb20 - 20%. Materials characterization was performed using the degree of conversion, cohesive strength, sorption, and solubility assays. Antimicrobial assay was performed using the modified direct contact test against E. faecalis and S. aureus. Cytotoxicity was assessed by the cell viability experiment using L929 fibroblasts. In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea1, Eb, and Eb1 groups showed moderate cytotoxic effect. The formulations containing alpha-humulene showed similar behavior to the commercial references. Thus, formulations containing alpha-humulene have potential to be used as periodontal dressing.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0091

14.

Fish fauna from a fragmented river in the Atlantic Forest
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Brito, Paulo Roberto Monteiro de

; Pereira, Luiz Henrique Garcia

; Roxo, Fábio Fernandes

; Monteiro, Jefferson Henriques

; Oiveira, Claudio

; Silva, Guilherme José da Costa

Biota Neotropica

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2022, Volume 22 Nº 2 elocation e20211286

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: Este estudo buscou identificar a composição da ictiofauna do rio Muzambinho, um tributário de terras altas do Rio Paraná. Também buscamos investigar se as cachoeiras da região podem servir de barreiras para dispersão de espécies de peixes. Para isso, foram realizadas coletas em 34 pontos do Rio Muzambinho, com diferentes técnicas. Ao todo foram registradas 37 espécies de peixes, sendo algumas endêmicas e a maioria nativa. Dentre essas espécies algumas são predominantes em locais degradados e podem ser usadas como bioindicadores. Os resultados também demonstram que há uma zonação na composição ictiofaunística no Muzambinho que segrega a fauna em três sessões separadas por cachoeiras, Baixo Muzambinho, Alto Muzambinho e São Domingos. Concluímos que para a ideal preservação da ictiofauna do rio Muzambinho é necessária a preservação independente de suas sessões o que garantiria a manutenção de linhagens naturalmente isoladas.

Abstract: This study sought to identify the ichthyofauna composition of the Muzambinho River, an upland tributary of the Paraná River. We also investigate whether waterfalls in the region can serve as barriers to the dispersal of fish species. For this purpose, collections were carried out at 34 points on the Muzambinho River using different techniques. In all, 37 species were recorded, some of which were endemic, and the majority were native. Among these species, some are predominant in degraded places and can be used as bioindicators. The results also demonstrate zonation in the ichthyofauna composition in Muzambinho that segregates the fauna into three sessions separated by waterfalls: Lower Muzambinho, Upper Muzambinho, and Sao Domingos. We conclude that, for the ideal preservation of the ichthyofauna of the Muzambinho River, it is necessary to preserve its sections independently, which would guarantee the maintenance of naturally isolated strains.

https://doi.org/10.1590/1676-0611-bn-2021-1286

15.

Health-Related Quality of Life Reported by Patients With Chagas Disease: A Systematic Review of Qualitative Evidence With GRADE Recommendations
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Silva, Whesley Tanor

; Oliveira, Lucas Frois Fernandes

; Xavier, Diego Mendes

; Figueiredo, Pedro Henrique Scheidt

; Lacerda, Ana Cristina Rodrigues

; Mendonça, Vanessa Amaral

; Ávila, Matheus Ribeiro

; Ferreira Júnior, Cláudio Luiz

; Lima, Márcia Maria Oliveira

; Mediano, Mauro Felippe Felix

; Rocha, Manoel Otávio da Costa

; Costa, Henrique Silveira

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0377-2022

Resumo: En | Texto: En | PDF: En

ABSTRACT Patients with Chagas disease have reduced health-related quality of life (HRQoL). Hence, we aimed to identify the factors that mostly affected their HRQoL. This was a systematic review of qualitative studies. The Latin American and Caribbean Health Sciences Literature, Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, Web of Science, and SciVerse Scopus databases were searched for relevant studies without language or date restrictions. The search and data analysis were performed by independent reviewers; all qualitative studies that reported the factors that had an impact on the HRQoL of patients with Chagas disease were included. The risk of bias was assessed using the Critical Appraisal Skills Program Qualitative Study Checklist; confidence in the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation-Confidence in the Evidence from Reviews of Qualitative approach. Five studies were included in this review: four in Brazil and one in California, United States, with immigrants from Central and South America. The sample consisted of 207 patients with chronic Chagas disease. Stigma, physical limitations, work absenteeism, emotional or mental aspects, fear of treatment, and fear of the future had the strongest impact on the HRQoL. All items showed moderate confidence except for fear of treatment (low confidence). The physical, emotional, mental, and cultural aspects affected the HRQoL of patients with chronic Chagas disease. Identification of these factors is important in the development of strategies aimed at improving the HRQoL of this population.

https://doi.org/10.1590/0037-8682-0377-2022

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